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2. A Pan-European Review of Good Practices in Early Intervention Safeguarding Practice with Children, Young People and Families: Evidence Gathering to Inform a Multi-disciplinary Training Programme (the ERICA Project) in Preventing Child Abuse and Neglect in Seven European Countries

Author

Appleton, J. V., Bekaert, S., Hucker, J., Zlatkute, G., Paavilainen, E., Schecke, H., Specka, M., Scherbaum, N., Jouet, E., Zabłocka-Żytka, L., Woźniak-Prus, M., Czabała, J. Cz., Kluczyńska, S., Bachi, B., Bartoli, F., Carrà, G., Cioni, R. M., Crocamo, C., Rantanen, H. E., Kaunonen, M., Nieminen, I., Roe, L., Keenan, K., Viganò, G., and Baldacchino, A.

Published
2023
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4. Anxious distress in people with major depressive episodes: a cross-sectional analysis of clinical correlates

Author

Bartoli, F, Bachi, B, Callovini, T, Palpella, D, Piacenti, S, Morreale, M, Di Lella, M, Crocamo, C, Carrà, G, Barbieri, F, Bartoccetti, A, Bassetti, C, Bernasconi, G, Bommartini, C, Bona, P, Boniello, F, Calabrese, A, Canestro, A, Capogrosso, C, Cavaleri, D, Castiglioni, M, Cioni, R, Colangelo, F, De Pietra, A, Frigeni, T, Gazzola, M, Gianfelice, L, Gandolfo, N, Guzzi, P, Lauria, G, Limonta, S, Lucini Paioni, S, Mauro, S, Molendini, M, Morello, P, Moretti, F, Nasti, C, Prestifilippo, L, Re, M, Camera, P, Bartoli F., Bachi B., Callovini T., Palpella D., Piacenti S., Morreale M., Di Lella M., Crocamo C., Carrà G., Barbieri F. F., Bartoccetti A., Bassetti C., Bernasconi G., Bommartini C., Bona P., Boniello F., Calabrese A., Canestro A., Capogrosso C. A., Cavaleri D., Castiglioni M., Cioni R. M., Colangelo F., De Pietra A., Frigeni T., Gazzola M., Gianfelice L., Gandolfo N., Guzzi P., Lauria G., Limonta S., Lucini Paioni S., Mauro S., Molendini M., Morello P., Moretti F., Nasti C., Prestifilippo L., Re M., Camera P., Bartoli, F, Bachi, B, Callovini, T, Palpella, D, Piacenti, S, Morreale, M, Di Lella, M, Crocamo, C, Carrà, G, Barbieri, F, Bartoccetti, A, Bassetti, C, Bernasconi, G, Bommartini, C, Bona, P, Boniello, F, Calabrese, A, Canestro, A, Capogrosso, C, Cavaleri, D, Castiglioni, M, Cioni, R, Colangelo, F, De Pietra, A, Frigeni, T, Gazzola, M, Gianfelice, L, Gandolfo, N, Guzzi, P, Lauria, G, Limonta, S, Lucini Paioni, S, Mauro, S, Molendini, M, Morello, P, Moretti, F, Nasti, C, Prestifilippo, L, Re, M, Camera, P, Bartoli F., Bachi B., Callovini T., Palpella D., Piacenti S., Morreale M., Di Lella M., Crocamo C., Carrà G., Barbieri F. F., Bartoccetti A., Bassetti C., Bernasconi G., Bommartini C., Bona P., Boniello F., Calabrese A., Canestro A., Capogrosso C. A., Cavaleri D., Castiglioni M., Cioni R. M., Colangelo F., De Pietra A., Frigeni T., Gazzola M., Gianfelice L., Gandolfo N., Guzzi P., Lauria G., Limonta S., Lucini Paioni S., Mauro S., Molendini M., Morello P., Moretti F., Nasti C., Prestifilippo L., Re M., and Camera P.

Abstract

Objective. Most people with major depressive episodes meet criteria for the anxiety distress (AD) specifier defined by DSM-5 as the presence of symptoms such as feeling of tension, restlessness, and difficulty concentrating, and fear that something awful may happen. This cross-sectional study was aimed at identifying clinical correlates of AD in people with unipolar or bipolar depression. Methods. Inpatients with a current major depressive episode were included. Data on sociodemographic and clinical variables were collected. The SCID-5 was used to diagnose depressive episodes and relevant specifiers. The Montgomery-Åsberg Depression Rating Scale (MADRS) and Young Mania Rating Scale (YMRS) were used to assess the severity of depression and symptoms of the opposite polarity (manic symptoms), respectively. Multiple logistic regression analyses were carried out to identify clinical correlates of AD. Results. We included 206 people (mean age: 48.4±18.6 yrs.; males: 38.8%) admitted for a major depressive episode (155 with major depressive disorder and 51 with bipolar disorder). Around two thirds of the sample (N=137; 66.5%) had AD. Multiple logistic regression models showed that AD was associated with mixed features, higher YMRS scores, psychotic features, and a diagnosis of major depressive disorder (p < 0.05). There were no other clinical variables associated with AD. Conclusion. Despite some limitations, including the cross-sectional design and the inpatient setting, our study shows that AD is likely to be associated with mixed and psychotic features, as well as with unipolar depression. The identification of these clinical domains may be helpful for clinicians to better contextualize AD in the context of major depressive episodes.

Published
2024

6. MeMoVolc report on classification and dynamics of volcanic explosive eruptions

Author

Bonadonna, C, Cioni, R, Costa, A, Druitt, T, Phillips, J, Pioli, L, Andronico, D, Harris, A, Scollo, S, Bachmann, O, Bagheri, G, Biass, S, Brogi, F, Cashman, K, Dominguez, L, Dürig, T, Galland, O, Giordano, G, Gudmundsson, M, Hort, M, Höskuldsson, A, Houghton, B, Komorowski, JC, Küppers, U, Lacanna, G, Le Pennec, JL, Macedonio, G, Manga, M, Manzella, I, Vitturi, M de’ Michieli, Neri, A, Pistolesi, M, Polacci, M, Ripepe, M, Rossi, E, Scheu, B, Sulpizio, R, Tripoli, B, Valade, S, Valentine, G, Vidal, C, and Wallenstein, N

Subjects
Earth Sciences, Geology, Geophysics, Volcanism, Eruption dynamics, Eruption classification, Eruptive products, Eruptive processes, Eruptive styles, Geochemistry & Geophysics, Geochemistry
Abstract

Classifications of volcanic eruptions were first introduced in the early twentieth century mostly based on qualitative observations of eruptive activity, and over time, they have gradually been developed to incorporate more quantitative descriptions of the eruptive products from both deposits and observations of active volcanoes. Progress in physical volcanology, and increased capability in monitoring, measuring and modelling of explosive eruptions, has highlighted shortcomings in the way we classify eruptions and triggered a debate around the need for eruption classification and the advantages and disadvantages of existing classification schemes. Here, we (i) review and assess existing classification schemes, focussing on subaerial eruptions; (ii) summarize the fundamental processes that drive and parameters that characterize explosive volcanism; (iii) identify and prioritize the main research that will improve the understanding, characterization and classification of volcanic eruptions and (iv) provide a roadmap for producing a rational and comprehensive classification scheme. In particular, classification schemes need to be objective-driven and simple enough to permit scientific exchange and promote transfer of knowledge beyond the scientific community. Schemes should be comprehensive and encompass a variety of products, eruptive styles and processes, including for example, lava flows, pyroclastic density currents, gas emissions and cinder cone or caldera formation. Open questions, processes and parameters that need to be addressed and better characterized in order to develop more comprehensive classification schemes and to advance our understanding of volcanic eruptions include conduit processes and dynamics, abrupt transitions in eruption regime, unsteadiness, eruption energy and energy balance.

Published
2016

8. Exploring depression in people with schizophrenia spectrum disorders: A cross-sectional analysis of the clinical relationship with Positive and Negative Syndrome Scale dimensions

Author

Bartoli, F, Calabrese, A, Moretti, F, Castiglioni, M, Prestifilippo, L, De Pietra, A, Gazzola, M, Camera, P, Crocamo, C, Carrà, G, Bachi, B, Barbieri, F, Bartoccetti, A, Bassetti, C, Bernasconi, G, Bommartini, C, Bona, P, Boniello, F, Callovini, T, Canestro, A, Capogrosso, C, Cavaleri, D, Cioni, R, Colangelo, F, Di Lella, M, Gianfelice, L, Guzzi, P, Lauria, G, Limonta, S, Lucini Paioni, S, Mauro, S, Morello, P, Morreale, M, Nasti, C, Palpella, D, Piacenti, S, Re, M, Villa, O, Bartoli, Francesco, Calabrese, Angela, Moretti, Federico, Castiglioni, Marta, Prestifilippo, Luca, De Pietra, Aldo, Gazzola, Marco, Camera, Paolo, Crocamo, Cristina, Carrà, Giuseppe, Bachi, Bianca, Barbieri, Filippo Fabio, Bartoccetti, Alessandra, Bassetti, Carlo, Bernasconi, Gianna, Bommartini, Carlo, Bona, Paolo, Boniello, Federica, Callovini, Tommaso, Canestro, Aurelia, Capogrosso, Chiara Alessandra, Cavaleri, Daniele, Cioni, Riccardo Matteo, Colangelo, Francesca, Di Lella, Maria Elisa, Gianfelice, Letizia, Guzzi, Pierluca, Lauria, Giada, Limonta, Serena, Lucini Paioni, Susanna, Mauro, Stefano, Morello, Pietro, Morreale, Marco, Nasti, Christian, Palpella, Dario, Piacenti, Susanna, Re, Martina, Villa, Oliviero., Bartoli, F, Calabrese, A, Moretti, F, Castiglioni, M, Prestifilippo, L, De Pietra, A, Gazzola, M, Camera, P, Crocamo, C, Carrà, G, Bachi, B, Barbieri, F, Bartoccetti, A, Bassetti, C, Bernasconi, G, Bommartini, C, Bona, P, Boniello, F, Callovini, T, Canestro, A, Capogrosso, C, Cavaleri, D, Cioni, R, Colangelo, F, Di Lella, M, Gianfelice, L, Guzzi, P, Lauria, G, Limonta, S, Lucini Paioni, S, Mauro, S, Morello, P, Morreale, M, Nasti, C, Palpella, D, Piacenti, S, Re, M, Villa, O, Bartoli, Francesco, Calabrese, Angela, Moretti, Federico, Castiglioni, Marta, Prestifilippo, Luca, De Pietra, Aldo, Gazzola, Marco, Camera, Paolo, Crocamo, Cristina, Carrà, Giuseppe, Bachi, Bianca, Barbieri, Filippo Fabio, Bartoccetti, Alessandra, Bassetti, Carlo, Bernasconi, Gianna, Bommartini, Carlo, Bona, Paolo, Boniello, Federica, Callovini, Tommaso, Canestro, Aurelia, Capogrosso, Chiara Alessandra, Cavaleri, Daniele, Cioni, Riccardo Matteo, Colangelo, Francesca, Di Lella, Maria Elisa, Gianfelice, Letizia, Guzzi, Pierluca, Lauria, Giada, Limonta, Serena, Lucini Paioni, Susanna, Mauro, Stefano, Morello, Pietro, Morreale, Marco, Nasti, Christian, Palpella, Dario, Piacenti, Susanna, Re, Martina, and Villa, Oliviero.

Abstract

OBJECTIVE: Evidence on the relationship between depression and clinical dimensions of schizophrenia remains limited. This cross-sectional study investigated the association between depression and Positive and Negative Syndrome Scale (PANSS) dimensions in people with schizophrenia spectrum disorders. METHODS: Trained assessors administered the PANSS to measure symptoms of schizophrenia and the Calgary Depression Scale for Schizophrenia to measure depression. The association of depression with overall PANSS score and related dimensions was investigated in multiple logistic regression analyses. RESULTS: We included 231 inpatients with schizophrenia spectrum disorders (mean age: 42.4 (SD: 12.9) years; men: 58.9%; mean overall PANSS score: 82.5 (SD: 20.1); drug-free or naïve: 39.3%), including 78 (33.8%) with clinically significant depressive symptoms. Depression was associated with higher overall (regression coefficient, SE: 0.029, 0.008; p < 0.001) and general psychopathology (regression coefficient, SE: 0.118, 0.023; p < 0.001) PANSS scores. We found an inverse relationship between depression and positive symptoms (regression coefficient, SE: -0.088, 0.028; p = 0.002). No association between depression and negative symptoms was found. CONCLUSION: Despite some limitations, our study shows that people affected by schizophrenia spectrum disorders with depression are likely to show more overall and general psychopathology symptoms but lower positive symptoms. Additional studies are needed to explore the generalizability of our findings.

Published
2024

9. Tolerability of vortioxetine compared to selective serotonin reuptake inhibitors in older adults with major depressive disorder (VESPA): a randomised, assessor-blinded and statistician-blinded, multicentre, superiority trial

Author

Ostuzzi, G, Gastaldon, C, Tettamanti, M, Cartabia, M, Monti, I, Aguglia, A, Aguglia, E, Bartoli, F, Callegari, C, Canozzi, A, Carbone, E, Carrà, G, Caruso, R, Cavallotti, S, Chiappini, S, Colasante, F, Compri, B, D'Agostino, A, De Fazio, P, de Filippis, R, Gari, M, Ielmini, M, Ingrosso, G, Mammarella, S, Martinotti, G, Rodolico, A, Roncone, R, Sterzi, E, Tarsitani, L, Tiberto, E, Todini, L, Amaddeo, F, D'Avanzo, B, Barbato, A, Barbui, C, Alessi, M, Avincola, G, Bachi, B, Bernasconi, G, Birgillito, A, Bisso, E, Bonora, S, Calabrese, A, Callovini, T, Canestro, A, Canonico, S, Capogrosso, C, Carosielli, D, Caselli, I, Cavaleri, D, Cavallotto, C, Cesca, M, Chiarenza, C, Cioni, R, Coloccini, S, Cruciata, M, Cumerlato, C, De Filippis, R, De Palma, M, Del Vecchio, S, Della Rocca, B, Di Natale, C, D'Onofrio, E, Espa, I, Fior, G, Gancitano, M, Giordano, B, Giusti, L, Grassi, L, Guzzi, P, Isella, C, Lax, A, Marano, L, Marconi, F, Marella, M, Metelli, A, Michencig, G, Miuli, A, Moncada, A, Morello, P, Moretti, F, Morreale, M, Mosca, A, Nasti, C, Nosé, M, Ogheri, F, Oresti, M, Ornaghi, A, Palpella, D, Pancheri, C, Papola, D, Passeri, S, Pettorusso, M, Piacenti, S, Pinucci, I, Pugliese, V, Purgato, M, Rania, M, Robbi, F, Romito, S, Ronchi, B, Roselli, V, Segura-Garcia, C, Signorelli, M, Simonelli, G, Sociali, A, Sturiale, S, Tambelli, A, Todesco, B, Trabucco, A, Turrini, G, Villa, V, Wiedenmann, F, Zambuto, L, Zanini, E, Zannini, C, Zerbinati, L, Ostuzzi, Giovanni, Gastaldon, Chiara, Tettamanti, Mauro, Cartabia, Massimo, Monti, Igor, Aguglia, Andrea, Aguglia, Eugenio, Bartoli, Francesco, Callegari, Camilla, Canozzi, Andrea, Carbone, Elvira Anna, Carrà, Giuseppe, Caruso, Rosangela, Cavallotti, Simone, Chiappini, Stefania, Colasante, Fabrizio, Compri, Beatrice, D'Agostino, Armando, De Fazio, Pasquale, de Filippis, Renato, Gari, Matteo, Ielmini, Marta, Ingrosso, Gianmarco, Mammarella, Silvia, Martinotti, Giovanni, Rodolico, Alessandro, Roncone, Rita, Sterzi, Enrico, Tarsitani, Lorenzo, Tiberto, Elisa, Todini, Liliana, Amaddeo, Francesco, D'Avanzo, Barbara, Barbato, Angelo, Barbui, Corrado, Alessi, Maria Chiara, Avincola, Gabriele, Bachi, Bianca, Bernasconi, Gianna, Birgillito, Andrea, Bisso, Emanuele, Bonora, Stefano, Calabrese, Angela, Callovini, Tommaso, Canestro, Aurelia, Canonico, Salvo, Capogrosso, Chiara Alessandra, Carbone, Elvira, Carosielli, Doriana, Caselli, Ivano, Cavaleri, Daniele, Cavallotto, Clara, Cesca, Marco, Chiarenza, Cecilia, Cioni, Riccardo Matteo, Coloccini, Sara, Cruciata, Marco, Cumerlato, Claudia, De Filippis, Renato, De Palma, Manuela, Del Vecchio, Sasha, Della Rocca, Bianca, Di Natale, Chiara, D'Onofrio, Ettore, Espa, Irene, Fior, Giulia, Gancitano, Marta, Giordano, Barbara, Giusti, Laura, Grassi, Luigi, Guzzi, Pierluca, Isella, Celeste, Lax, Annamaria, Marano, Leonardo, Marconi, Federico, Marella, Marco, Metelli, Alessia, Michencig, Giulia, Miuli, Andrea, Moncada, Alessandro, Morello, Pietro, Moretti, Federico, Morreale, Marco, Mosca, Alessio, Nasti, Christian, Nosé, Michela, Ogheri, Filippo, Oresti, Margherita, Ornaghi, Alessandra, Palpella, Dario, Pancheri, Corinna, Papola, Davide, Passeri, Silvia, Pettorusso, Mauro, Piacenti, Susanna, Pinucci, Irene, Pugliese, Valentina, Purgato, Marianna, Rania, Marianna, Robbi, Federica, Romito, Samantha, Ronchi, Barbara, Roselli, Valentina, Segura-Garcia, Cristina, Signorelli, Maria Salvina, Simonelli, Gabriele, Sociali, Antonella, Sturiale, Serena, Tambelli, Antonio, Todesco, Beatrice, Trabucco, Alice, Turrini, Giulia, Villa, Veronica, Wiedenmann, Federico, Zambuto, Luca, Zanini, Elisa, Zannini, Chiara, Zerbinati, Luigi, Ostuzzi, G, Gastaldon, C, Tettamanti, M, Cartabia, M, Monti, I, Aguglia, A, Aguglia, E, Bartoli, F, Callegari, C, Canozzi, A, Carbone, E, Carrà, G, Caruso, R, Cavallotti, S, Chiappini, S, Colasante, F, Compri, B, D'Agostino, A, De Fazio, P, de Filippis, R, Gari, M, Ielmini, M, Ingrosso, G, Mammarella, S, Martinotti, G, Rodolico, A, Roncone, R, Sterzi, E, Tarsitani, L, Tiberto, E, Todini, L, Amaddeo, F, D'Avanzo, B, Barbato, A, Barbui, C, Alessi, M, Avincola, G, Bachi, B, Bernasconi, G, Birgillito, A, Bisso, E, Bonora, S, Calabrese, A, Callovini, T, Canestro, A, Canonico, S, Capogrosso, C, Carosielli, D, Caselli, I, Cavaleri, D, Cavallotto, C, Cesca, M, Chiarenza, C, Cioni, R, Coloccini, S, Cruciata, M, Cumerlato, C, De Filippis, R, De Palma, M, Del Vecchio, S, Della Rocca, B, Di Natale, C, D'Onofrio, E, Espa, I, Fior, G, Gancitano, M, Giordano, B, Giusti, L, Grassi, L, Guzzi, P, Isella, C, Lax, A, Marano, L, Marconi, F, Marella, M, Metelli, A, Michencig, G, Miuli, A, Moncada, A, Morello, P, Moretti, F, Morreale, M, Mosca, A, Nasti, C, Nosé, M, Ogheri, F, Oresti, M, Ornaghi, A, Palpella, D, Pancheri, C, Papola, D, Passeri, S, Pettorusso, M, Piacenti, S, Pinucci, I, Pugliese, V, Purgato, M, Rania, M, Robbi, F, Romito, S, Ronchi, B, Roselli, V, Segura-Garcia, C, Signorelli, M, Simonelli, G, Sociali, A, Sturiale, S, Tambelli, A, Todesco, B, Trabucco, A, Turrini, G, Villa, V, Wiedenmann, F, Zambuto, L, Zanini, E, Zannini, C, Zerbinati, L, Ostuzzi, Giovanni, Gastaldon, Chiara, Tettamanti, Mauro, Cartabia, Massimo, Monti, Igor, Aguglia, Andrea, Aguglia, Eugenio, Bartoli, Francesco, Callegari, Camilla, Canozzi, Andrea, Carbone, Elvira Anna, Carrà, Giuseppe, Caruso, Rosangela, Cavallotti, Simone, Chiappini, Stefania, Colasante, Fabrizio, Compri, Beatrice, D'Agostino, Armando, De Fazio, Pasquale, de Filippis, Renato, Gari, Matteo, Ielmini, Marta, Ingrosso, Gianmarco, Mammarella, Silvia, Martinotti, Giovanni, Rodolico, Alessandro, Roncone, Rita, Sterzi, Enrico, Tarsitani, Lorenzo, Tiberto, Elisa, Todini, Liliana, Amaddeo, Francesco, D'Avanzo, Barbara, Barbato, Angelo, Barbui, Corrado, Alessi, Maria Chiara, Avincola, Gabriele, Bachi, Bianca, Bernasconi, Gianna, Birgillito, Andrea, Bisso, Emanuele, Bonora, Stefano, Calabrese, Angela, Callovini, Tommaso, Canestro, Aurelia, Canonico, Salvo, Capogrosso, Chiara Alessandra, Carbone, Elvira, Carosielli, Doriana, Caselli, Ivano, Cavaleri, Daniele, Cavallotto, Clara, Cesca, Marco, Chiarenza, Cecilia, Cioni, Riccardo Matteo, Coloccini, Sara, Cruciata, Marco, Cumerlato, Claudia, De Filippis, Renato, De Palma, Manuela, Del Vecchio, Sasha, Della Rocca, Bianca, Di Natale, Chiara, D'Onofrio, Ettore, Espa, Irene, Fior, Giulia, Gancitano, Marta, Giordano, Barbara, Giusti, Laura, Grassi, Luigi, Guzzi, Pierluca, Isella, Celeste, Lax, Annamaria, Marano, Leonardo, Marconi, Federico, Marella, Marco, Metelli, Alessia, Michencig, Giulia, Miuli, Andrea, Moncada, Alessandro, Morello, Pietro, Moretti, Federico, Morreale, Marco, Mosca, Alessio, Nasti, Christian, Nosé, Michela, Ogheri, Filippo, Oresti, Margherita, Ornaghi, Alessandra, Palpella, Dario, Pancheri, Corinna, Papola, Davide, Passeri, Silvia, Pettorusso, Mauro, Piacenti, Susanna, Pinucci, Irene, Pugliese, Valentina, Purgato, Marianna, Rania, Marianna, Robbi, Federica, Romito, Samantha, Ronchi, Barbara, Roselli, Valentina, Segura-Garcia, Cristina, Signorelli, Maria Salvina, Simonelli, Gabriele, Sociali, Antonella, Sturiale, Serena, Tambelli, Antonio, Todesco, Beatrice, Trabucco, Alice, Turrini, Giulia, Villa, Veronica, Wiedenmann, Federico, Zambuto, Luca, Zanini, Elisa, Zannini, Chiara, and Zerbinati, Luigi

Abstract

Background: Major depressive disorder (MDD) is prevalent and disabling among older adults. Standing on its tolerability profile, vortioxetine might be a promising alternative to selective serotonin reuptake inhibitors (SSRIs) in such a vulnerable population. Methods: We conducted a randomised, assessor- and statistician-blinded, superiority trial including older adults with MDD. The study was conducted between 02/02/2019 and 02/22/2023 in 11 Italian Psychiatric Services. Participants were randomised to vortioxetine or one of the SSRIs, selected according to common practice. Treatment discontinuation due to adverse events after six months was the primary outcome, for which we aimed to detect a 12% difference in favour of vortioxetine. The study was registered in the online repository clinicaltrials.gov (NCT03779789). Findings: The intention-to-treat population included 179 individuals randomised to vortioxetine and 178 to SSRIs. Mean age was 73.7 years (standard deviation 6.1), and 264 participants (69%) were female. Of those on vortioxetine, 78 (44%) discontinued the treatment due to adverse events at six months, compared to 59 (33%) of those on SSRIs (odds ratio 1.56; 95% confidence interval 1.01–2.39). Adjusted and per-protocol analyses confirmed point estimates in favour of SSRIs, but without a significant difference. With the exception of the unadjusted survival analysis showing SSRIs to outperform vortioxetine, secondary outcomes provided results consistent with a lack of substantial safety and tolerability differences between the two arms. Overall, no significant differences emerged in terms of response rates, depressive symptoms and quality of life, while SSRIs outperformed vortioxetine in terms of cognitive performance. Interpretation: As opposed to what was previously hypothesised, vortioxetine did not show a better tolerability profile compared to SSRIs in older adults with MDD in this study. Additionally, hypothetical advantages of vortioxetine on depress

Published
2024

10. Clinical correlates of comorbid attention deficit hyperactivity disorder in adults suffering from bipolar disorder: A meta-analysis

Author

Bartoli, F, Callovini, T, Cavaleri, D, Cioni, R, Bachi, B, Calabrese, A, Moretti, F, Canestro, A, Morreale, M, Nasti, C, Palpella, D, Piacenti, S, Nacinovich, R, Riboldi, I, Crocamo, C, Carra, G, Bartoli F., Callovini T., Cavaleri D., Cioni R. M., Bachi B., Calabrese A., Moretti F., Canestro A., Morreale M., Nasti C., Palpella D., Piacenti S., Nacinovich R., Riboldi I., Crocamo C., Carra G., Bartoli, F, Callovini, T, Cavaleri, D, Cioni, R, Bachi, B, Calabrese, A, Moretti, F, Canestro, A, Morreale, M, Nasti, C, Palpella, D, Piacenti, S, Nacinovich, R, Riboldi, I, Crocamo, C, Carra, G, Bartoli F., Callovini T., Cavaleri D., Cioni R. M., Bachi B., Calabrese A., Moretti F., Canestro A., Morreale M., Nasti C., Palpella D., Piacenti S., Nacinovich R., Riboldi I., Crocamo C., and Carra G.

Abstract

Objective: Attention deficit hyperactivity disorder is a frequent comorbid condition in adults with bipolar disorder. We performed a meta-analysis aimed at assessing sociodemographic and clinical correlates of attention deficit hyperactivity disorder in bipolar disorder. Method: We searched main electronic databases up to June 2021. Random-effects meta-analyses, with relevant meta-regression and quality-based sensitivity analyses, were carried out to estimate the association between attention deficit hyperactivity disorder and putative correlates, grading the quality of evidence. Results: We included 43 studies, based on 38 independent samples. Attention deficit hyperactivity disorder participants were more likely to be males (odds ratio = 1.46; p < 0.001) and unemployed (odds ratio = 1.45; p = 0.045), and less likely to be married (odds ratio = 0.62; p = 0.014). They had an earlier onset of bipolar disorder (standardized mean difference = −0.36; p < 0.001); more mood episodes (standardized mean difference = 0.35; p = 0.007), particularly depressive (standardized mean difference = 0.30; p = 0.011) and mixed (standardized mean difference = 0.30; p = 0.031) ones; higher odds of using antidepressants (odds ratio = 1.80; p = 0.024) and attempted suicides (odds ratio = 1.83; p < 0.001) and lower odds of psychotic features (odds ratio = 0.63; p = 0.010). Moreover, they were more likely to have generalized anxiety disorder (odds ratio = 1.50; p = 0.019), panic disorder (odds ratio = 1.89; p < 0.001), social phobia (odds ratio = 1.61; p = 0.017), eating disorders (odds ratio = 1.91; p = 0.007), antisocial personality disorder (odds ratio = 3.59; p = 0.004) and substance (odds ratio = 2.29; p < 0.001) or alcohol (odds ratio = 2.28; p < 0.001) use disorders. Quality of the evidence was generally low or very low for the majority of correlates, except for bipolar disorder onset and alcohol/substance use disorders (high), and suicide attempts (moderate). Conclu

Published
2023

11. A Pan-European Review of Good Practices in Early Intervention Safeguarding Practice with Children, Young People and Families: Evidence Gathering to Inform a Multi-disciplinary Training Programme (the ERICA Project) in Preventing Child Abuse and Neglect in Seven European Countries

Author

Appleton, J, Bekaert, S, Hucker, J, Zlatkute, G, Paavilainen, E, Schecke, H, Specka, M, Scherbaum, N, Jouet, E, Zabłocka-Żytka, L, Woźniak-Prus, M, Czabała, J, Kluczyńska, S, Bachi, B, Bartoli, F, Carrà, G, Cioni, R, Crocamo, C, Rantanen, H, Kaunonen, M, Nieminen, I, Roe, L, Keenan, K, Viganò, G, Baldacchino, A, Appleton, J. V., Bekaert, S., Hucker, J., Zlatkute, G., Paavilainen, E., Schecke, H., Specka, M., Scherbaum, N., Jouet, E., Zabłocka-Żytka, L., Woźniak-Prus, M., Czabała, J. Cz., Kluczyńska, S., Bachi, B., Bartoli, F., Carrà, G., Cioni, R. M., Crocamo, C., Rantanen, H. E., Kaunonen, M., Nieminen, I., Roe, L., Keenan, K., Viganò, G., Baldacchino, A., Appleton, J, Bekaert, S, Hucker, J, Zlatkute, G, Paavilainen, E, Schecke, H, Specka, M, Scherbaum, N, Jouet, E, Zabłocka-Żytka, L, Woźniak-Prus, M, Czabała, J, Kluczyńska, S, Bachi, B, Bartoli, F, Carrà, G, Cioni, R, Crocamo, C, Rantanen, H, Kaunonen, M, Nieminen, I, Roe, L, Keenan, K, Viganò, G, Baldacchino, A, Appleton, J. V., Bekaert, S., Hucker, J., Zlatkute, G., Paavilainen, E., Schecke, H., Specka, M., Scherbaum, N., Jouet, E., Zabłocka-Żytka, L., Woźniak-Prus, M., Czabała, J. Cz., Kluczyńska, S., Bachi, B., Bartoli, F., Carrà, G., Cioni, R. M., Crocamo, C., Rantanen, H. E., Kaunonen, M., Nieminen, I., Roe, L., Keenan, K., Viganò, G., and Baldacchino, A.

Abstract

Child maltreatment has detrimental social and health effects for individuals, families and communities. The ERICA project is a pan-European training programme that equips non-specialist threshold practitioners with knowledge and skills to prevent and detect child maltreatment. This paper describes and presents the findings of a rapid review of good practice examples across seven participating countries including local services, programmes and risk assessment tools used in the detection and prevention of child maltreatment in the family. Learning was applied to the development of the generic training project. A template for mapping the good practice examples was collaboratively developed by the seven participating partner countries. A descriptive data analysis was undertaken organised by an a priori analysis framework. Examples were organised into three areas: programmes tackling child abuse and neglect, local practices in assessment and referral, risk assessment tools. Key findings were identified using a thematic approach. Seventy-two good practice examples were identified and categorised according to area, subcategory and number. A typology was developed as follows: legislative frameworks, child health promotion programmes, national guidance on child maltreatment, local practice guidance, risk assessment tools, local support services, early intervention programmes, telephone or internet-based support services, COVID-19 related good practices. Improved integration of guidance into practice and professional training in child development were highlighted as overarching needs. The impact of COVID-19 on safeguarding issues was apparent. The ERICA training programme formally responded to the learning identified in this international good practice review.

Published
2023

12. Products and dynamics of lava-snow explosions: The 16 March 2017 explosion at Mount Etna, Italy.

Author

Cioni, R., Andronico, D., Cappelli, L., Aravena, A., Gabellini, P., Cristaldi, A., Corsaro, R. A., Cantarero, M., Ciancitto, F., De Beni, E., and Ganci, G.

Subjects
*EXPLOSIONS, *HAZARD mitigation, *LAVA, *SNOW cover, *LAVA flows, *VAPOR pressure, *VOLCANOES
Abstract

Volcanic hazards associated with lava flows advancing on snow cover are often underrated, although sudden explosions related to different processes of lava-snow/ice contact can occur rapidly and are only preceded by small, easily underrated precursors. On 16 March 2017, during a mildly effusive and explosive eruption at Mount Etna, Italy, a slowly advancing lava lobe interacted with the snow cover to produce a sudden, brief sequence of explosions. White vapor, brown ash, and coarse material were suddenly ejected, and the products struck a group of people, injuring some of them. The proximal deposit formed a continuous mantle of ash, lapilli, and decimeter-sized bombs, while the ballistic material travelled up to 200 m from the lava edge. The deposit was estimated to have a mass of 7.1 ± 0.8 x 104 kg, which corresponds to a volume of 32.0 ± 3.6 m³ of lava being removed by the explosion. Data related to the texture and morphology of the ejected clasts were used to constrain a model of lava-snow interaction. The results suggest that the mechanism causing the explosions was the progressive build-up of pressure due to vapor accumulation under the lava flow, while no evidence was found for the occurrence of fuel-coolant interaction processes. Although these low-intensity explosions are not particularly frequent, the data set collected provides, for the first time, quantitative information about the processes involved and the associated hazard and suggests that mitigation measures should be established to prevent potentially dramatic accidents at worldwide volcanoes frequented by tourists and with fairly easy access, such as Etna. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Innovations in community-based mental health care: an overview of meta-analyses

Author

Carra, G, Bartoli, F, Capogrosso, C, Cioni, R, Moretti, F, Piacenti, S, Riboldi, I, Crocamo, C, Bebbington, P, Carra G., Bartoli F., Capogrosso C. A., Cioni R. M., Moretti F., Piacenti S., Riboldi I., Crocamo C., Bebbington P. E., Carra, G, Bartoli, F, Capogrosso, C, Cioni, R, Moretti, F, Piacenti, S, Riboldi, I, Crocamo, C, Bebbington, P, Carra G., Bartoli F., Capogrosso C. A., Cioni R. M., Moretti F., Piacenti S., Riboldi I., Crocamo C., and Bebbington P. E.

Abstract

In the last four decades, mental health services for people with Severe Mental Illness (SMI) have seen asylums replaced by a balanced model of Community Mental Healthcare (CMH). Innovative approaches and strategies in the field of CMH have been extensively researched. However, this research has been hampered by issues limiting their capacity to inform clinicians and policymakers. We conducted an overview of meta-analyses of the effectiveness of innovative CMH models focussing on clinical and psychosocial outcomes in comparisons with standard care in adults with SMI. Based on the 12 eligible studies, we appraised, synthesised and graded the resulting evidence. There was moderate quality evidence that case management, Early Intervention Services (EIS) and caregiver-directed interventions were superior to standard care in reducing hospital admission. In relation to psychosocial outcomes, EIS showed high quality evidence of a small effect on global functioning. There was moderate quality evidence for a similar effect of Intensive Case Management, and for a large effect of family intervention. For quality of life, both EIS and self-management education had a small effect, with moderate quality. The level of research about effective CMH models is therefore substantial. However, several gaps related to innovative CMH not yet covered in meta‐analytic synthesis, need to be filled.

Published
2022

17. Effect of long-acting injectable antipsychotics on emergency department visits and hospital admissions in people with bipolar disorder: A retrospective mirror-image analysis from the Northern Milan Area Cohort (NOMIAC) study

Author

Bartoli, F, Bachi, B, Calabrese, A, Cioni, R, Guzzi, P, Nasti, C, Palpella, D, Barbieri, F, Limonta, S, Crocamo, C, Carra, G, Bartoli F., Bachi B., Calabrese A., Cioni R. M., Guzzi P., Nasti C., Palpella D., Barbieri F. F., Limonta S., Crocamo C., Carra G., Bartoli, F, Bachi, B, Calabrese, A, Cioni, R, Guzzi, P, Nasti, C, Palpella, D, Barbieri, F, Limonta, S, Crocamo, C, Carra, G, Bartoli F., Bachi B., Calabrese A., Cioni R. M., Guzzi P., Nasti C., Palpella D., Barbieri F. F., Limonta S., Crocamo C., and Carra G.

Abstract

Background: Mood recurrences in bipolar disorder (BD) are often associated with poor treatment adherence. Despite long-acting injectable antipsychotics (LAIs) may favor treatment compliance, their use in BD is still poorly explored. Methods: This mirror-image study investigated the effect of LAIs initiation on the number of emergency department (ED) visits and days of hospitalization, among individuals with BD from the mental health services of a large area of the Metropolitan City of Milan. The mirror periods were 365 days either side of the LAI initiation. Individual medical records were retrospectively reviewed. Results: Sixty-eight individuals with BD initiating a LAI over the index period were included. We estimated that LAI initiation overall reduced both ED visits (p = 0.002) and days of hospitalization (p < 0.001). This remained true only for those participants who i) continued LAI for the entire 12-month period of observation and ii) were treated with a second-generation antipsychotic LAI. In addition, LAI initiation reduced number of hospitalization days during hypo/manic (p = 0.013), but not depressive (p = 0.641) episodes, as well as compulsory admission days (p = 0.002). Limitations: Due to the retrospective design, we could not collect systematic information on symptom severity and reasons of LAI discontinuation. Moreover, the limited sample size did not allow us to estimate effectiveness of single LAI agents. Conclusions: Our study provides additional insight on the effectiveness of LAIs in BD, supporting their clinical utility for pragmatic outcomes such as ED visits and hospitalizations. Further longitudinal research is needed to clarify the real-world effectiveness of LAIs for BD clinical management.

Published
2022

18. Disentangling the Association between ADHD and Alcohol Use Disorder in Individuals Suffering from Bipolar Disorder: A Systematic Review and Meta-Analysis

Author

Bartoli, F, Callovini, T, Calabrese, A, Cioni, R, Riboldi, I, Crocamo, C, Carra, G, Bartoli F., Callovini T., Calabrese A., Cioni R. M., Riboldi I., Crocamo C., Carra G., Bartoli, F, Callovini, T, Calabrese, A, Cioni, R, Riboldi, I, Crocamo, C, Carra, G, Bartoli F., Callovini T., Calabrese A., Cioni R. M., Riboldi I., Crocamo C., and Carra G.

Abstract

Attention Deficit-Hyperactivity disorder (ADHD) may influence rates of Alcohol Use Disorder (AUD) among individuals suffering from Bipolar Disorder (BD). The aim of this systematic review and meta-analysis was to estimate the strength and consistency of the potential association between ADHD and AUD in BD. We searched main electronic databases for studies indexed up to November 2020. We included observational studies investigating the association between ADHD and AUD among individuals with BD. The association between ADHD and AUD was estimated using odds ratios (ORs) with 95% Confidence Intervals (CIs). Eleven studies, involving 2734 individuals with BD (516 with ADHD), were included in the meta-analysis. Individuals with both BD and ADHD had higher rates of AUD as compared with subjects with BD only (34.0% vs. 18.3%). The estimated OR of AUD for ADHD was 2.50 (95% CI: 1.91 to 3.27; I2 = 13.0%). Study-level characteristics did not influence the effect size. No risk of publication bias was estimated. Despite some limitations, this meta-analysis estimated an association between ADHD and AUD among individuals suffering from BD. At least a portion of the high rates of AUD in BD may, thereby, be related to comorbid ADHD. Longitudinal studies are needed to clarify the nature of this relationship.

Published
2022

19. EE275 Personalised Versus Standard Dosimetry for Selective Internal Radiation Therapy in Patients With Hepatocellular Carcinoma: A Cost-Effectiveness Analysis

Author

Rognoni, C, primary, Barcellona, MR, additional, Bargellini, I, additional, Bavetta, MG, additional, Bellò, M, additional, Brunetto, M, additional, Carucci, P, additional, Cioni, R, additional, Crocetti, L, additional, D'amato, F, additional, D'amico, M, additional, Deagostini, S, additional, Deandreis, D, additional, De Simone, P, additional, Doriguzzi, A, additional, Finessi, M, additional, Fonio, P, additional, Grimaldi, S, additional, Ialuna, S, additional, Lagattuta, F, additional, Masi, G, additional, Moreci, A, additional, Scalisi, D, additional, Virdone, R, additional, and Tarricone, R, additional

Published
2022
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20. A Pan-European Review of Good Practices in Early Intervention Safeguarding Practice with Children, Young People and Families: Evidence Gathering to Inform a Multi-disciplinary Training Programme (the ERICA Project) in Preventing Child Abuse and Neglect in Seven European Countries

Author

Appleton, J. V., primary, Bekaert, S., additional, Hucker, J., additional, Zlatkute, G., additional, Paavilainen, E., additional, Schecke, H., additional, Specka, M., additional, Scherbaum, N., additional, Jouet, E., additional, Zabłocka-Żytka, L., additional, Woźniak-Prus, M., additional, Czabała, J. Cz., additional, Kluczyńska, S., additional, Bachi, B., additional, Bartoli, F., additional, Carrà, G., additional, Cioni, R. M., additional, Crocamo, C., additional, Rantanen, H. E., additional, Kaunonen, M., additional, Nieminen, I., additional, Roe, L., additional, Keenan, K., additional, Viganò, G., additional, and Baldacchino, A., additional

Published
2022
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24. Trauma quality indicators: internationally approved core factors for trauma management quality evaluation

Author

Coccolini, F, Kluger, Y, Moore, E, Maier, R, Coimbra, R, Ordonez, C, Ivatury, R, Kirkpatrick, A, Biffl, W, Sartelli, M, Hecker, A, Ansaloni, L, Leppaniemi, A, Reva, V, Civil, I, Vega, F, Chiarugi, M, Chichom-Mefire, A, Sakakushev, B, Peitzman, A, Chiara, O, Abu-Zidan, F, Maegele, M, Miccoli, M, Chirica, M, Khokha, V, Sugrue, M, Fraga, G, Otomo, Y, Baiocchi, G, Catena, F, Kuliesius, Z, Conti, L, Dogjani, A, Lee, J, Consani, H, Russello, D, Bortul, M, Maurel, T, Kaf, H, Adamou, H, Alin, V, Robustelli, U, Sato, N, Seretis, C, Quiodettis, M, Gomes, C, Kong, V, Zakaria, A, Guner, A, Gachabayov, M, Chowdhury, S, Pata, F, Garcia, A, Rems, M, Das, K, Riedel, J, Lasithiotakis, K, Sydorchuk, R, Sydorchuk, L, Lostoridis, E, Buia, A, Mcfarlane, M, Ciani, R, Munoz-Cruzado, V, Tartaglia, D, Ioannidis, O, Muhrbeck, M, Reicher, M, Roscio, F, Ceresoli, M, Tsiftsis, D, Kavalakat, A, Pintar, T, Georgiou, G, Ricci, G, Mohan, R, Saar, S, Di Carlo, I, Isik, A, Ahmed, A, Gonsaga, R, Sammartano, F, Tallon-Aguilar, L, Shoko, T, Hsu, J, Kobe, Y, Romeo, C, Podda, M, Mingoli, A, Delgado, R, Ekwen, G, Aude, V, Olona, C, Boati, P, Magnone, S, Capaldi, M, Bala, M, Picetti, E, Negoi, I, Kok, K, Jusoh, A, Amato, B, Nita, G, de Beaux, A, Demetrashvili, Z, Davies, R, Kim, J, Pereira, A, Fattori, L, Paolillo, C, Ghannam, W, Rodriguez, F, Berardi, L, Florio, M, Hecker, M, Dubuisson, V, O'Connor, D, De'Angelis, N, Dobric, I, Massalou, D, Ortenwall, P, Pikoulis, E, Ugarte-Sierra, B, Zuidema, W, Kechagias, A, Marwah, S, Litvin, A, Nikolopoulos, I, Pesce, A, Uranues, S, Luppi, D, Flohe, S, Martinez-Perez, A, Lorenzo, M, Vergano, L, Manca, M, Malacarne, P, Kurihara, H, Widder, S, Pucciarelli, M, Monzani, F, Brambillasca, P, Corbella, D, Agresta, F, Moore, L, Buonomo, L, Adeleye, A, Kim, D, Veroux, M, Hardcastle, T, Di Saverio, S, Recordare, A, Rubio-Perez, I, Shlyapnikov, S, Rahim, R, Vega, G, Boris, K, Sawyer, R, Baraket, O, Soreide, K, Weber, C, Seak, C, Herman, S, Gamberini, E, Costa, S, Mazzocconi, G, Lozada, E, Manatakis, D, Lohsiriwat, V, Elbery, B, Tiberio, G, Santini, M, Mellace, L, Enoksen, C, Major, P, Parini, D, Improta, M, Fugazzola, P, Pini, S, Liberti, G, Martino, C, Cobianchi, L, Canzi, G, Cicuttin, E, Kenig, J, Zago, M, Giannessi, S, Scaglione, M, Orsitto, E, Cioni, R, Ghiadoni, L, Menichetti, F, Agnoletti, V, Sganga, G, Prosperi, P, Roviello, F, De Paolis, P, Gordini, G, Forfori, F, Ruscelli, P, Gabrielli, F, Puglisi, A, Bertolucci, A, Marchi, S, Bellini, M, Casagli, S, De Simone, B, Carmassi, F, Marchetti, S, Accorsini, M, Cremonini, C, Morelli, F, Romeo, L, Coccolini F., Kluger Y., Moore E. E., Maier R. V., Coimbra R., Ordonez C., Ivatury R., Kirkpatrick A. W., Biffl W., Sartelli M., Hecker A., Ansaloni L., Leppaniemi A., Reva V., Civil I., Vega F., Chiarugi M., Chichom-Mefire A., Sakakushev B., Peitzman A., Chiara O., Abu-Zidan F., Maegele M., Miccoli M., Chirica M., Khokha V., Sugrue M., Fraga G. P., Otomo Y., Baiocchi G. L., Catena F., Kuliesius Z., Conti L., Dogjani A., Lee J. G., Consani H., Russello D., Bortul M., Maurel T. G., Kaf H. S., Adamou H., Alin V., Robustelli U., Sato N., Seretis C., Quiodettis M., Gomes C. A., Kong V., Zakaria A. D., Guner A., Gachabayov M., Chowdhury S., Pata F., Garcia A., Rems M., Das K., Riedel J. G., Lasithiotakis K., Sydorchuk R., Sydorchuk L., Lostoridis E., Buia A., McFarlane M., Ciani R., Munoz-Cruzado V. M. D., Tartaglia D., Ioannidis O., Muhrbeck M., Reicher M., Roscio F., Ceresoli M., Tsiftsis D., Kavalakat A., Pintar T., Georgiou G., Ricci G., Mohan R., Saar S., Di Carlo I., Isik A., Ahmed A. Y. Y. M., Gonsaga R. A. T., Sammartano F., Tallon-Aguilar L., Shoko T., Hsu J., Kobe Y., Romeo C. G. L., Podda M., Mingoli A., Delgado R. C., Ekwen G., Aude V., Olona C., Boati P., Magnone S., Capaldi M., Bala M., Picetti E., Negoi I., Kok K. Y. Y., Jusoh A. C., Amato B., Nita G. E., de Beaux A., Demetrashvili Z., Davies R. J., Kim J. I., Pereira A., Fattori L., Paolillo C., Ghannam W., Rodriguez F. M., Berardi L., Florio M. G., Hecker M., Dubuisson V., O'Connor D. B., De'Angelis N., Dobric I., Massalou D., Ortenwall P., Pikoulis E., Ugarte-Sierra B., Zuidema W. P., Kechagias A., Marwah S., Litvin A., Nikolopoulos I., Pesce A., Uranues S., Luppi D., Flohe S., Martinez-Perez A., Lorenzo M., Vergano L. B., Manca M., Malacarne P., Kurihara H., Widder S., Pucciarelli M., Monzani F., Brambillasca P., Corbella D., Agresta F., Moore L., Buonomo L. A., Adeleye A. O., Kim D., Veroux M., Hardcastle T. C., Di Saverio S., Recordare A., Rubio-Perez I., Shlyapnikov S., Rahim R., Vega G. M. M., Boris K., Sawyer R., Baraket O., Soreide K., Weber C., Seak C. -J., Herman S., Gamberini E., Costa S., Mazzocconi G., Lozada E., Manatakis D., Lohsiriwat V., Ahmed A., Elbery B., Tiberio G. A. M., Santini M., Mellace L., Enoksen C. H., Major P., Parini D., Improta M., Fugazzola P., Pini S., Liberti G., Martino C., Cobianchi L., Canzi G., Cicuttin E., Kenig J., Zago M., Giannessi S., Scaglione M., Orsitto E., Cioni R., Ghiadoni L., Menichetti F., Agnoletti V., Sganga G., Prosperi P., Roviello F., De Paolis P., Gordini G., Forfori F., Ruscelli P., Gabrielli F., Puglisi A., Bertolucci A., Marchi S., Bellini M., Casagli S., De Simone B., Carmassi F., Marchetti S., Accorsini M., Cremonini C., Morelli F., Romeo L., Coccolini, F, Kluger, Y, Moore, E, Maier, R, Coimbra, R, Ordonez, C, Ivatury, R, Kirkpatrick, A, Biffl, W, Sartelli, M, Hecker, A, Ansaloni, L, Leppaniemi, A, Reva, V, Civil, I, Vega, F, Chiarugi, M, Chichom-Mefire, A, Sakakushev, B, Peitzman, A, Chiara, O, Abu-Zidan, F, Maegele, M, Miccoli, M, Chirica, M, Khokha, V, Sugrue, M, Fraga, G, Otomo, Y, Baiocchi, G, Catena, F, Kuliesius, Z, Conti, L, Dogjani, A, Lee, J, Consani, H, Russello, D, Bortul, M, Maurel, T, Kaf, H, Adamou, H, Alin, V, Robustelli, U, Sato, N, Seretis, C, Quiodettis, M, Gomes, C, Kong, V, Zakaria, A, Guner, A, Gachabayov, M, Chowdhury, S, Pata, F, Garcia, A, Rems, M, Das, K, Riedel, J, Lasithiotakis, K, Sydorchuk, R, Sydorchuk, L, Lostoridis, E, Buia, A, Mcfarlane, M, Ciani, R, Munoz-Cruzado, V, Tartaglia, D, Ioannidis, O, Muhrbeck, M, Reicher, M, Roscio, F, Ceresoli, M, Tsiftsis, D, Kavalakat, A, Pintar, T, Georgiou, G, Ricci, G, Mohan, R, Saar, S, Di Carlo, I, Isik, A, Ahmed, A, Gonsaga, R, Sammartano, F, Tallon-Aguilar, L, Shoko, T, Hsu, J, Kobe, Y, Romeo, C, Podda, M, Mingoli, A, Delgado, R, Ekwen, G, Aude, V, Olona, C, Boati, P, Magnone, S, Capaldi, M, Bala, M, Picetti, E, Negoi, I, Kok, K, Jusoh, A, Amato, B, Nita, G, de Beaux, A, Demetrashvili, Z, Davies, R, Kim, J, Pereira, A, Fattori, L, Paolillo, C, Ghannam, W, Rodriguez, F, Berardi, L, Florio, M, Hecker, M, Dubuisson, V, O'Connor, D, De'Angelis, N, Dobric, I, Massalou, D, Ortenwall, P, Pikoulis, E, Ugarte-Sierra, B, Zuidema, W, Kechagias, A, Marwah, S, Litvin, A, Nikolopoulos, I, Pesce, A, Uranues, S, Luppi, D, Flohe, S, Martinez-Perez, A, Lorenzo, M, Vergano, L, Manca, M, Malacarne, P, Kurihara, H, Widder, S, Pucciarelli, M, Monzani, F, Brambillasca, P, Corbella, D, Agresta, F, Moore, L, Buonomo, L, Adeleye, A, Kim, D, Veroux, M, Hardcastle, T, Di Saverio, S, Recordare, A, Rubio-Perez, I, Shlyapnikov, S, Rahim, R, Vega, G, Boris, K, Sawyer, R, Baraket, O, Soreide, K, Weber, C, Seak, C, Herman, S, Gamberini, E, Costa, S, Mazzocconi, G, Lozada, E, Manatakis, D, Lohsiriwat, V, Elbery, B, Tiberio, G, Santini, M, Mellace, L, Enoksen, C, Major, P, Parini, D, Improta, M, Fugazzola, P, Pini, S, Liberti, G, Martino, C, Cobianchi, L, Canzi, G, Cicuttin, E, Kenig, J, Zago, M, Giannessi, S, Scaglione, M, Orsitto, E, Cioni, R, Ghiadoni, L, Menichetti, F, Agnoletti, V, Sganga, G, Prosperi, P, Roviello, F, De Paolis, P, Gordini, G, Forfori, F, Ruscelli, P, Gabrielli, F, Puglisi, A, Bertolucci, A, Marchi, S, Bellini, M, Casagli, S, De Simone, B, Carmassi, F, Marchetti, S, Accorsini, M, Cremonini, C, Morelli, F, Romeo, L, Coccolini F., Kluger Y., Moore E. E., Maier R. V., Coimbra R., Ordonez C., Ivatury R., Kirkpatrick A. W., Biffl W., Sartelli M., Hecker A., Ansaloni L., Leppaniemi A., Reva V., Civil I., Vega F., Chiarugi M., Chichom-Mefire A., Sakakushev B., Peitzman A., Chiara O., Abu-Zidan F., Maegele M., Miccoli M., Chirica M., Khokha V., Sugrue M., Fraga G. P., Otomo Y., Baiocchi G. L., Catena F., Kuliesius Z., Conti L., Dogjani A., Lee J. G., Consani H., Russello D., Bortul M., Maurel T. G., Kaf H. S., Adamou H., Alin V., Robustelli U., Sato N., Seretis C., Quiodettis M., Gomes C. A., Kong V., Zakaria A. D., Guner A., Gachabayov M., Chowdhury S., Pata F., Garcia A., Rems M., Das K., Riedel J. G., Lasithiotakis K., Sydorchuk R., Sydorchuk L., Lostoridis E., Buia A., McFarlane M., Ciani R., Munoz-Cruzado V. M. D., Tartaglia D., Ioannidis O., Muhrbeck M., Reicher M., Roscio F., Ceresoli M., Tsiftsis D., Kavalakat A., Pintar T., Georgiou G., Ricci G., Mohan R., Saar S., Di Carlo I., Isik A., Ahmed A. Y. Y. M., Gonsaga R. A. T., Sammartano F., Tallon-Aguilar L., Shoko T., Hsu J., Kobe Y., Romeo C. G. L., Podda M., Mingoli A., Delgado R. C., Ekwen G., Aude V., Olona C., Boati P., Magnone S., Capaldi M., Bala M., Picetti E., Negoi I., Kok K. Y. Y., Jusoh A. C., Amato B., Nita G. E., de Beaux A., Demetrashvili Z., Davies R. J., Kim J. I., Pereira A., Fattori L., Paolillo C., Ghannam W., Rodriguez F. M., Berardi L., Florio M. G., Hecker M., Dubuisson V., O'Connor D. B., De'Angelis N., Dobric I., Massalou D., Ortenwall P., Pikoulis E., Ugarte-Sierra B., Zuidema W. P., Kechagias A., Marwah S., Litvin A., Nikolopoulos I., Pesce A., Uranues S., Luppi D., Flohe S., Martinez-Perez A., Lorenzo M., Vergano L. B., Manca M., Malacarne P., Kurihara H., Widder S., Pucciarelli M., Monzani F., Brambillasca P., Corbella D., Agresta F., Moore L., Buonomo L. A., Adeleye A. O., Kim D., Veroux M., Hardcastle T. C., Di Saverio S., Recordare A., Rubio-Perez I., Shlyapnikov S., Rahim R., Vega G. M. M., Boris K., Sawyer R., Baraket O., Soreide K., Weber C., Seak C. -J., Herman S., Gamberini E., Costa S., Mazzocconi G., Lozada E., Manatakis D., Lohsiriwat V., Ahmed A., Elbery B., Tiberio G. A. M., Santini M., Mellace L., Enoksen C. H., Major P., Parini D., Improta M., Fugazzola P., Pini S., Liberti G., Martino C., Cobianchi L., Canzi G., Cicuttin E., Kenig J., Zago M., Giannessi S., Scaglione M., Orsitto E., Cioni R., Ghiadoni L., Menichetti F., Agnoletti V., Sganga G., Prosperi P., Roviello F., De Paolis P., Gordini G., Forfori F., Ruscelli P., Gabrielli F., Puglisi A., Bertolucci A., Marchi S., Bellini M., Casagli S., De Simone B., Carmassi F., Marchetti S., Accorsini M., Cremonini C., Morelli F., and Romeo L.

Abstract

Introduction: Quality in medical care must be measured in order to be improved. Trauma management is part of health care, and by definition, it must be checked constantly. The only way to measure quality and outcomes is to systematically accrue data and analyze them. Material and methods: A systematic revision of the literature about quality indicators in trauma associated to an international consensus conference Results: An internationally approved base core set of 82 trauma quality indicators was obtained: Indicators were divided into 6 fields: prevention, structure, process, outcome, post-traumatic management, and society integrational effects. Conclusion: Present trauma quality indicator core set represents the result of an international effort aiming to provide a useful tool in quality evaluation and improvement. Further improvement may only be possible through international trauma registry development. This will allow for huge international data accrual permitting to evaluate results and compare outcomes.

Published
2021

25. Family members’ perspectives of child protection services, a metasynthesis of the literature

Author

Bekaert, S, Paavilainen, E, Schecke, H, Baldacchino, A, Jouet, E, Zablocka - Zytka, L, Bachi, B, Bartoli, F, Carra, G, Cioni, R, Crocamo, C, Appleton, J, Bekaert S., Paavilainen E., Schecke H., Baldacchino A., Jouet E., Zablocka - Zytka L., Bachi B., Bartoli F., Carra G., Cioni R. M., Crocamo C., Appleton J. V., Bekaert, S, Paavilainen, E, Schecke, H, Baldacchino, A, Jouet, E, Zablocka - Zytka, L, Bachi, B, Bartoli, F, Carra, G, Cioni, R, Crocamo, C, Appleton, J, Bekaert S., Paavilainen E., Schecke H., Baldacchino A., Jouet E., Zablocka - Zytka L., Bachi B., Bartoli F., Carra G., Cioni R. M., Crocamo C., and Appleton J. V.

Abstract

This metasynthesis brings together what is known about family members’ perspectives of their relationship with social care practitioners as a starting point for developing a pan-European training resource for practitioners. Four databases were searched for qualitative literature with search terms relating to family members and social care practitioners. After the application of inclusion and exclusion criteria, 35 studies were critically appraised and were included in the metasynthesis. Three broad themes were identified through a thematic analysis of the studies’ findings: family members’ perspectives of the system; perceptions of how they were viewed by their worker; and view of their worker. The following aspects are discussed: whether partnership between family and worker is possible within a legal framework; the detrimental effects of cultural bias; and practical foundations for building trust. Recommendations are made for practical support, reflection on cultural practice and broader service provision.

Published
2021

27. The kynurenine pathway in bipolar disorder: a meta-analysis on the peripheral blood levels of tryptophan and related metabolites

Author

Bartoli, F, Misiak, B, Callovini, T, Cavaleri, D, Cioni, R, Crocamo, C, Savitz, J, Carra, G, Bartoli F., Misiak B., Callovini T., Cavaleri D., Cioni R. M., Crocamo C., Savitz J. B., Carra Giuseppe, Bartoli, F, Misiak, B, Callovini, T, Cavaleri, D, Cioni, R, Crocamo, C, Savitz, J, Carra, G, Bartoli F., Misiak B., Callovini T., Cavaleri D., Cioni R. M., Crocamo C., Savitz J. B., and Carra Giuseppe

Abstract

Growing evidence suggests that a dysregulation of the kynurenine pathway (KP) occurs in bipolar disorder (BD). This systematic review and meta-analysis aimed at assessing the possible differences in peripheral blood levels of KP metabolites between individuals with BD and healthy controls. We searched Medline, Embase, and PsycInfo electronic databases for articles indexed up to February 2020. We included any observational study comparing the peripheral blood levels of at least one KP metabolite between adults with BD and healthy controls. Random-effects meta-analyses were carried out generating pooled standardized mean differences (SMDs). Heterogeneity between studies was estimated using the I2 index. Meta-regression and sensitivity analyses were conducted. Sixteen studies met inclusion criteria and were included in our study. Meta-analyses showed that individuals with BD have lower peripheral blood levels of tryptophan (SMD = −0.29), kynurenine (SMD = −0.28), kynurenic acid (SMD = −0.30), and xanthurenic acid (SMD = −0.55), along with lower kynurenic acid to kynurenine (SMD = −0.60) and kynurenic acid to quinolinic acid (SMD = −0.37) ratios, than healthy controls. Individuals with a manic episode showed the greatest reductions in tryptophan levels (SMD = −0.51), whereas kynurenic acid levels were more reduced among subjects in a depressive phase (SMD = −0.70). Meta-regression and sensitivity analyses confirmed our results. The findings of the present meta-analysis support the hypothesis of an abnormality of the KP in BD. Considering the partial inconsistency of the findings and the small-to-medium magnitude of the estimated effect sizes, additional research assessing possible mediators or confounders is needed.

Published
2021

29. Clinical Application of Trans-Arterial Radioembolization in Hepatic Malignancies in Europe: First Results from the Prospective Multicentre Observational Study CIRSE Registry for SIR-Spheres Therapy (CIRT)

Author

Helmberger T., Golfieri R., Pech M., Pfammatter T., Arnold D., Cianni R., Maleux G., Munneke G., Pellerin O., Peynircioglu B., Sangro B., Schaefer N., de Jong N., Bilbao J. I., Pelage J. -P., Manas D. M., Kolligs F. T., Ezziddin S., Peters R., Albrecht T., D'Archambeau O., Balli T., Bilgic S., Bloom A., Cioni R., Fischbach R., Flamen P., Gerard L., Grozinger G., Katoh M., Koehler M., Kroger J. R., Kuhl C., Orsi F., Ozgun M., Reimer P., Ronot M., Schmid A., Vit A., Helmberger T., Golfieri R., Pech M., Pfammatter T., Arnold D., Cianni R., Maleux G., Munneke G., Pellerin O., Peynircioglu B., Sangro B., Schaefer N., de Jong N., Bilbao J.I., Pelage J.-P., Manas D.M., Kolligs F.T., Ezziddin S., Peters R., Albrecht T., D'Archambeau O., Balli T., Bilgic S., Bloom A., Cioni R., Fischbach R., Flamen P., Gerard L., Grozinger G., Katoh M., Koehler M., Kroger J.R., Kuhl C., Orsi F., Ozgun M., Reimer P., Ronot M., Schmid A., Vit A., University of Zurich, On behalf of the CIRT Steering Committee, On behalf of the CIRT Principal Investigators, Pelage, J.P., Manas, D.M., Kolligs, F.T., Ezziddin, S., Peters, R., Albrecht, T., D'Archambeau, O., Balli, T., Bilgic, S., Bloom, A., Cioni, R., Fischbach, R., Flamen, P., Gerard, L., Grözinger, G., Katoh, M., Koehler, M., Kröger, J.R., Kuhl, C., Orsi, F., Ozgun, M., Reimer, P., Ronot, M., Schmid, A., and Vit, A.

Subjects
Male, Registrie, SIR-Spheres, Yttrium-90, Cardiac & Cardiovascular Systems, Tare weight, Colorectal cancer, Hepatocellular carcinoma, medicine.medical_treatment, Metastasi, Radioisotope brachytherapy, COLORECTAL-CANCER, Metastasis, 030218 nuclear medicine & medical imaging, 0302 clinical medicine, Observational study, Medicine, Yttrium Radioisotopes, Prospective Studies, Registries, SALVAGE THERAPY, Y-90 RADIOEMBOLIZATION, 10042 Clinic for Diagnostic and Interventional Radiology, Incidence, Mortality rate, Radiology, Nuclear Medicine & Medical Imaging, Liver Neoplasms, CANCER LIVER METASTASES, Middle Aged, Embolization, Therapeutic, Microspheres, Europe, Trans-arterial radioembolization, Liver, SAFETY, 030220 oncology & carcinogenesis, Female, Cardiology and Cardiovascular Medicine, Life Sciences & Biomedicine, medicine.medical_specialty, Carcinoma, Hepatocellular, 610 Medicine & health, Context (language use), Therapeutic embolization, 03 medical and health sciences, Breast cancer, GLASS MICROSPHERES, ADVANCED HEPATOCELLULAR-CARCINOMA, Pancreatic cancer, Internal medicine, INTRAHEPATIC CHOLANGIOCARCINOMA, Humans, Radiology, Nuclear Medicine and imaging, Clinical Investigation, Retrospective Studies, Science & Technology, INTERNAL RADIATION-THERAPY, business.industry, EFFICACY, medicine.disease, Radiography, Cardiovascular System & Cardiology, business
Abstract

Purpose To address the lack of prospective data on the real-life clinical application of trans-arterial radioembolization (TARE) in Europe, the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) initiated the prospective observational study CIRSE Registry for SIR-Spheres® Therapy (CIRT). Materials and Methods Patients were enrolled from 1 January 2015 till 31 December 2017. Eligible patients were adult patients treated with TARE with Y90 resin microspheres for primary or metastatic liver tumours. Patients were followed up for 24 months after treatment, whereas data on the clinical context of TARE, overall survival (OS) and safety were collected. Results Totally, 1027 patients were analysed. 68.2% of the intention of treatment was palliative. Up to half of the patients received systemic therapy and/or locoregional treatments prior to TARE (53.1%; 38.3%). Median overall survival (OS) was reported per cohort and was 16.5 months (95% confidence interval (CI) 14.2–19.3) for hepatocellular carcinoma, 14.6 months (95% CI 10.9–17.9) for intrahepatic cholangiocarcinoma. For liver metastases, median OS for colorectal cancer was 9.8 months (95% CI 8.3–12.9), 5.6 months for pancreatic cancer (95% CI 4.1–6.6), 10.6 months (95% CI 7.3–14.4) for breast cancer, 14.6 months (95% CI 7.3–21.4) for melanoma and 33.1 months (95% CI 22.1–nr) for neuroendocrine tumours. Statistically significant prognostic factors in terms of OS include the presence of ascites, cirrhosis, extra-hepatic disease, patient performance status (Eastern Cooperative Oncology Group), number of chemotherapy lines prior to TARE and tumour burden. Thirty-day mortality rate was 1.0%. 2.5% experienced adverse events grade 3 or 4 within 30 days after TARE. Conclusion In the real-life clinical setting, TARE is largely considered to be a part of a palliative treatment strategy across indications and provides an excellent safety profile. Level of evidence Level 3. Trial registration ClinicalTrials.gov NCT02305459.

Published
2021

30. Trauma quality indicators: internationally approved core factors for trauma management quality evaluation

Author

Coccolini, F., Kluger, Y., Moore, E. E., Maier, R. V., Coimbra, R., Ordonez, C., Ivatury, R., Kirkpatrick, A. W., Biffl, W., Sartelli, M., Hecker, A., Ansaloni, L., Leppaniemi, A., Reva, V., Civil, I., Vega, F., Chiarugi, M., Chichom-Mefire, A., Sakakushev, B., Peitzman, A., Chiara, O., Abu-Zidan, F., Maegele, M., Miccoli, M., Chirica, M., Khokha, V., Sugrue, M., Fraga, G. P., Otomo, Y., Baiocchi, G. L., Catena, F., Kuliesius, Z., Conti, L., Dogjani, A., Lee, J. G., Consani, H., Russello, D., Bortul, M., Maurel, T. G., Kaf, H. S., Adamou, H., Alin, V., Robustelli, U., Sato, N., Seretis, C., Quiodettis, M., Gomes, C. A., Kong, V., Zakaria, A. D., Guner, A., Gachabayov, M., Chowdhury, S., Pata, F., Garcia, A., Rems, M., Das, K., Riedel, J. G., Lasithiotakis, K., Sydorchuk, R., Sydorchuk, L., Lostoridis, E., Buia, A., Mcfarlane, M., Ciani, R., Munoz-Cruzado, V. M. D., Tartaglia, D., Ioannidis, O., Muhrbeck, M., Reicher, M., Roscio, F., Ceresoli, M., Tsiftsis, D., Kavalakat, A., Pintar, T., Georgiou, G., Ricci, G., Mohan, R., Saar, S., Di Carlo, I., Isik, A., Ahmed, A. Y. Y. M., Gonsaga, R. A. T., Sammartano, F., Tallon-Aguilar, L., Shoko, T., Hsu, J., Kobe, Y., Romeo, C. G. L., Podda, M., Mingoli, A., Delgado, R. C., Ekwen, G., Aude, V., Olona, C., Boati, P., Magnone, S., Capaldi, M., Bala, M., Picetti, E., Negoi, I., Kok, K. Y. Y., Jusoh, A. C., Amato, B., Nita, G. E., de Beaux, A., Demetrashvili, Z., Davies, R. J., Kim, J. I., Pereira, A., Fattori, L., Paolillo, C., Ghannam, W., Rodriguez, F. M., Berardi, L., Florio, M. G., Hecker, M., Dubuisson, V., O'Connor, D. B., De'Angelis, N., Dobric, I., Massalou, D., Ortenwall, P., Pikoulis, E., Ugarte-Sierra, B., Zuidema, W. P., Kechagias, A., Marwah, S., Litvin, A., Nikolopoulos, I., Pesce, A., Uranues, S., Luppi, D., Flohe, S., Martinez-Perez, A., Lorenzo, M., Vergano, L. B., Manca, M., Malacarne, P., Kurihara, H., Widder, S., Pucciarelli, M., Monzani, F., Brambillasca, P., Corbella, D., Agresta, F., Moore, L., Buonomo, L. A., Adeleye, A. O., Kim, D., Veroux, M., Hardcastle, T. C., Di Saverio, S., Recordare, A., Rubio-Perez, I., Shlyapnikov, S., Rahim, R., Vega, G. M. M., Boris, K., Sawyer, R., Baraket, O., Soreide, K., Weber, C., Seak, C. -J., Herman, S., Gamberini, E., Costa, S., Mazzocconi, G., Lozada, E., Manatakis, D., Lohsiriwat, V., Ahmed, A., Elbery, B., Tiberio, G. A. M., Santini, M., Mellace, L., Enoksen, C. H., Major, P., Parini, D., Improta, M., Fugazzola, P., Pini, S., Liberti, G., Martino, C., Cobianchi, L., Canzi, G., Cicuttin, E., Kenig, J., Zago, M., Giannessi, S., Scaglione, M., Orsitto, E., Cioni, R., Ghiadoni, L., Menichetti, F., Agnoletti, V., Sganga, G., Prosperi, P., Roviello, F., De Paolis, P., Gordini, G., Forfori, F., Ruscelli, P., Gabrielli, F., Puglisi, A., Bertolucci, A., Marchi, S., Bellini, M., Casagli, S., De Simone, B., Carmassi, F., Marchetti, S., Accorsini, M., Cremonini, C., Morelli, F., Romeo, L., Coccolini F., Kluger Y., Moore E.E., Maier R.V., Coimbra R., Ordonez C., Ivatury R., Kirkpatrick A.W., Biffl W., Sartelli M., Hecker A., Ansaloni L., Leppaniemi A., Reva V., Civil I., Vega F., Chiarugi M., Chichom-Mefire A., Sakakushev B., Peitzman A., Chiara O., Abu-Zidan F., Maegele M., Miccoli M., Chirica M., Khokha V., Sugrue M., Fraga G.P., Otomo Y., Baiocchi G.L., Catena F., Kuliesius Z., Conti L., Dogjani A., Lee J.G., Consani H., Russello D., Bortul M., Maurel T.G., Kaf H.S., Adamou H., Alin V., Robustelli U., Sato N., Seretis C., Quiodettis M., Gomes C.A., Kong V., Zakaria A.D., Guner A., Gachabayov M., Chowdhury S., Pata F., Garcia A., Rems M., Das K., Riedel J.G., Lasithiotakis K., Sydorchuk R., Sydorchuk L., Lostoridis E., Buia A., McFarlane M., Ciani R., Munoz-Cruzado V.M.D., Tartaglia D., Ioannidis O., Muhrbeck M., Reicher M., Roscio F., Ceresoli M., Tsiftsis D., Kavalakat A., Pintar T., Georgiou G., Ricci G., Mohan R., Saar S., Di Carlo I., Isik A., Ahmed A.Y.Y.M., Gonsaga R.A.T., Sammartano F., Tallon-Aguilar L., Shoko T., Hsu J., Kobe Y., Romeo C.G.L., Podda M., Mingoli A., Delgado R.C., Ekwen G., Aude V., Olona C., Boati P., Magnone S., Capaldi M., Bala M., Picetti E., Negoi I., Kok K.Y.Y., Jusoh A.C., Amato B., Nita G.E., de Beaux A., Demetrashvili Z., Davies R.J., Kim J.I., Pereira A., Fattori L., Paolillo C., Ghannam W., Rodriguez F.M., Berardi L., Florio M.G., Hecker M., Dubuisson V., O'Connor D.B., De'Angelis N., Dobric I., Massalou D., Ortenwall P., Pikoulis E., Ugarte-Sierra B., Zuidema W.P., Kechagias A., Marwah S., Litvin A., Nikolopoulos I., Pesce A., Uranues S., Luppi D., Flohe S., Martinez-Perez A., Lorenzo M., Vergano L.B., Manca M., Malacarne P., Kurihara H., Widder S., Pucciarelli M., Monzani F., Brambillasca P., Corbella D., Agresta F., Moore L., Buonomo L.A., Adeleye A.O., Kim D., Veroux M., Hardcastle T.C., Di Saverio S., Recordare A., Rubio-Perez I., Shlyapnikov S., Rahim R., Vega G.M.M., Boris K., Sawyer R., Baraket O., Soreide K., Weber C., Seak C.-J., Herman S., Gamberini E., Costa S., Mazzocconi G., Lozada E., Manatakis D., Lohsiriwat V., Ahmed A., Elbery B., Tiberio G.A.M., Santini M., Mellace L., Enoksen C.H., Major P., Parini D., Improta M., Fugazzola P., Pini S., Liberti G., Martino C., Cobianchi L., Canzi G., Cicuttin E., Kenig J., Zago M., Giannessi S., Scaglione M., Orsitto E., Cioni R., Ghiadoni L., Menichetti F., Agnoletti V., Sganga G., Prosperi P., Roviello F., De Paolis P., Gordini G., Forfori F., Ruscelli P., Gabrielli F., Puglisi A., Bertolucci A., Marchi S., Bellini M., Casagli S., De Simone B., Carmassi F., Marchetti S., Accorsini M., Cremonini C., Morelli F., Romeo L., Coccolini, F, Kluger, Y, Moore, E, Maier, R, Coimbra, R, Ordonez, C, Ivatury, R, Kirkpatrick, A, Biffl, W, Sartelli, M, Hecker, A, Ansaloni, L, Leppaniemi, A, Reva, V, Civil, I, Vega, F, Chiarugi, M, Chichom-Mefire, A, Sakakushev, B, Peitzman, A, Chiara, O, Abu-Zidan, F, Maegele, M, Miccoli, M, Chirica, M, Khokha, V, Sugrue, M, Fraga, G, Otomo, Y, Baiocchi, G, Catena, F, Kuliesius, Z, Conti, L, Dogjani, A, Lee, J, Consani, H, Russello, D, Bortul, M, Maurel, T, Kaf, H, Adamou, H, Alin, V, Robustelli, U, Sato, N, Seretis, C, Quiodettis, M, Gomes, C, Kong, V, Zakaria, A, Guner, A, Gachabayov, M, Chowdhury, S, Pata, F, Garcia, A, Rems, M, Das, K, Riedel, J, Lasithiotakis, K, Sydorchuk, R, Sydorchuk, L, Lostoridis, E, Buia, A, Mcfarlane, M, Ciani, R, Munoz-Cruzado, V, Tartaglia, D, Ioannidis, O, Muhrbeck, M, Reicher, M, Roscio, F, Ceresoli, M, Tsiftsis, D, Kavalakat, A, Pintar, T, Georgiou, G, Ricci, G, Mohan, R, Saar, S, Di Carlo, I, Isik, A, Ahmed, A, Gonsaga, R, Sammartano, F, Tallon-Aguilar, L, Shoko, T, Hsu, J, Kobe, Y, Romeo, C, Podda, M, Mingoli, A, Delgado, R, Ekwen, G, Aude, V, Olona, C, Boati, P, Magnone, S, Capaldi, M, Bala, M, Picetti, E, Negoi, I, Kok, K, Jusoh, A, Amato, B, Nita, G, de Beaux, A, Demetrashvili, Z, Davies, R, Kim, J, Pereira, A, Fattori, L, Paolillo, C, Ghannam, W, Rodriguez, F, Berardi, L, Florio, M, Hecker, M, Dubuisson, V, O'Connor, D, De'Angelis, N, Dobric, I, Massalou, D, Ortenwall, P, Pikoulis, E, Ugarte-Sierra, B, Zuidema, W, Kechagias, A, Marwah, S, Litvin, A, Nikolopoulos, I, Pesce, A, Uranues, S, Luppi, D, Flohe, S, Martinez-Perez, A, Lorenzo, M, Vergano, L, Manca, M, Malacarne, P, Kurihara, H, Widder, S, Pucciarelli, M, Monzani, F, Brambillasca, P, Corbella, D, Agresta, F, Moore, L, Buonomo, L, Adeleye, A, Kim, D, Veroux, M, Hardcastle, T, Di Saverio, S, Recordare, A, Rubio-Perez, I, Shlyapnikov, S, Rahim, R, Vega, G, Boris, K, Sawyer, R, Baraket, O, Soreide, K, Weber, C, Seak, C, Herman, S, Gamberini, E, Costa, S, Mazzocconi, G, Lozada, E, Manatakis, D, Lohsiriwat, V, Elbery, B, Tiberio, G, Santini, M, Mellace, L, Enoksen, C, Major, P, Parini, D, Improta, M, Fugazzola, P, Pini, S, Liberti, G, Martino, C, Cobianchi, L, Canzi, G, Cicuttin, E, Kenig, J, Zago, M, Giannessi, S, Scaglione, M, Orsitto, E, Cioni, R, Ghiadoni, L, Menichetti, F, Agnoletti, V, Sganga, G, Prosperi, P, Roviello, F, De Paolis, P, Gordini, G, Forfori, F, Ruscelli, P, Gabrielli, F, Puglisi, A, Bertolucci, A, Marchi, S, Bellini, M, Casagli, S, De Simone, B, Carmassi, F, Marchetti, S, Accorsini, M, Cremonini, C, Morelli, F, Romeo, L, and HUS Abdominal Center

Subjects
System, Consensus, Internationality, Delphi Technique, Accrual, Process (engineering), media_common.quotation_subject, Performance, education, lcsh:Surgery, 030230 surgery, Analysis, Data, Morbidity, Mortality, Outcome, Planning, Product, World, 03 medical and health sciences, 0302 clinical medicine, Trauma management, Health care, Medicine, Humans, Operations management, Quality (business), Product (category theory), media_common, Quality Indicators, Health Care, Core set, business.industry, lcsh:Medical emergencies. Critical care. Intensive care. First aid, Analysi, lcsh:RD1-811, lcsh:RC86-88.9, CARE, 3126 Surgery, anesthesiology, intensive care, radiology, Core (game theory), Traumatology, Emergency Medicine, Surgery, business, Research Article
Abstract

Introduction Quality in medical care must be measured in order to be improved. Trauma management is part of health care, and by definition, it must be checked constantly. The only way to measure quality and outcomes is to systematically accrue data and analyze them. Material and methods A systematic revision of the literature about quality indicators in trauma associated to an international consensus conference Results An internationally approved base core set of 82 trauma quality indicators was obtained: Indicators were divided into 6 fields: prevention, structure, process, outcome, post-traumatic management, and society integrational effects. Conclusion Present trauma quality indicator core set represents the result of an international effort aiming to provide a useful tool in quality evaluation and improvement. Further improvement may only be possible through international trauma registry development. This will allow for huge international data accrual permitting to evaluate results and compare outcomes.

Published
2021

32. MeMoVolc consensual document: a review of cross-disciplinary approaches to characterizing small explosive magmatic eruptions

Author

Gurioli, L., Andronico, D., Bachelery, P., Balcone-Boissard, H., Battaglia, J., Boudon, G., Burgisser, A., Burton, M. R., Cashman, K., Cichy, S., Cioni, R., Di Muro, A., Dominguez, L., D’Oriano, C., Druitt, T., Harris, A. J. L., Hort, M., Kelfoun, K., Komorowski, J. C., Kueppers, U., Le Pennec, J. L., Menand, T., Paris, R., Pioli, L., Pistolesi, M., Polacci, M., Pompilio, M., Ripepe, M., Roche, O., Rose-Koga, E., Rust, A., Schiavi, F., Scharff, L., Sulpizio, R., Taddeucci, J., and Thordarson, T.

Published
2015
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33. The association of kynurenine pathway metabolites with symptom severity and clinical features of bipolar disorder: An overview

Author

Bartoli, F, Cioni, R, Cavaleri, D, Callovini, T, Crocamo, C, Misiak, B, Savitz, J, Carrà, G, Francesco Bartoli, Riccardo M. Cioni, Daniele Cavaleri, Tommaso Callovini, Cristina Crocamo, Blazej Misiak, Jonathan B. Savitz, Giuseppe Carrà, Bartoli, F, Cioni, R, Cavaleri, D, Callovini, T, Crocamo, C, Misiak, B, Savitz, J, Carrà, G, Francesco Bartoli, Riccardo M. Cioni, Daniele Cavaleri, Tommaso Callovini, Cristina Crocamo, Blazej Misiak, Jonathan B. Savitz, and Giuseppe Carrà

Abstract

Background. The balance between neurotoxic and neuroprotective effects of kynurenine pathway (KP) components has been recently proposed as a key element in the pathophysiology of bipolar disorder (BD) and related mood episodes. This comprehensive overview explored the link of KP with symptom severity and other clinical features of BD. Methods. We searched Medline, Embase, and PsycInfo electronic databases for studies assessing the association of peripheral and/or central concentrations of KP metabolites with putative clinical features, including symptom severity and other clinical domains in BD. Results. We included the findings of 13 observational studies investigating the possible variations of KP metabolites according to symptom severity, psychotic features, suicidal behaviors, and sleep disturbances in BD. Studies testing the relationship between KP metabolites and depression severity generated mixed and inconsistent findings. No statistically significant correlations with manic symptoms were found. Moreover, heterogeneous variations of the KP across different clinical domains were shown. Few available studies found (a) higher levels of cerebrospinal fluid kynurenic acid and lower of plasma quinolinic acid in BD with psychotic features, (b) lower central and peripheral picolinic acid levels in BD with suicide attempts, and (c) no significant correlations between KP metabolites and BD-related sleep disturbances. Conclusions. An imbalance of KP metabolism toward the neurotoxic branches is likely to occur in people with BD, though evidence on variations according to specific clinical features of BD is less clear. Additional research is needed to clarify the role of KP in the etiopathogenesis of BD and related clinical features.

Published
2022

34. Professionals’ Digital Training for Child Maltreatment Prevention in the COVID-19 Era: A Pan-European Model

Author

Crocamo, C, Bachi, B, Cioni, R, Schecke, H, Nieminen, I, Zabłocka-Żytka, L, Woźniak-Prus, M, Bartoli, F, Riboldi, I, Appleton, J, Bekaert, S, Zlatkute, G, Jouet, E, Viganò, G, Specka, M, Scherbaum, N, Paavilainen, E, Baldacchino, A, Carrà, G, Crocamo, Cristina, Bachi, Bianca, Cioni, Riccardo M., Schecke, Henrike, Nieminen, Irja, Zabłocka-Żytka, Lidia, Woźniak-Prus, Małgorzata, Bartoli, Francesco, Riboldi, Ilaria, Appleton, Jane V., Bekaert, Sarah, Zlatkute, Giedre, Jouet, Emmanuelle, Viganò, Giovanni, Specka, Michael, Scherbaum, Norbert, Paavilainen, Eija, Baldacchino, Alexander, Carrà, Giuseppe, Crocamo, C, Bachi, B, Cioni, R, Schecke, H, Nieminen, I, Zabłocka-Żytka, L, Woźniak-Prus, M, Bartoli, F, Riboldi, I, Appleton, J, Bekaert, S, Zlatkute, G, Jouet, E, Viganò, G, Specka, M, Scherbaum, N, Paavilainen, E, Baldacchino, A, Carrà, G, Crocamo, Cristina, Bachi, Bianca, Cioni, Riccardo M., Schecke, Henrike, Nieminen, Irja, Zabłocka-Żytka, Lidia, Woźniak-Prus, Małgorzata, Bartoli, Francesco, Riboldi, Ilaria, Appleton, Jane V., Bekaert, Sarah, Zlatkute, Giedre, Jouet, Emmanuelle, Viganò, Giovanni, Specka, Michael, Scherbaum, Norbert, Paavilainen, Eija, Baldacchino, Alexander, and Carrà, Giuseppe

Abstract

The responsiveness of professionals working with children and families is of key importance for child maltreatment early identification. However, this might be undermined when multifaceted circumstances, such as the COVID-19 pandemic, reduce interdisciplinary educational activities. Thanks to technological developments, digital platforms seem promising in dealing with new challenges for professionals’ training. We examined a digital approach to child maltreatment training through the ERICA project experience (Stopping Child Maltreatment through Pan-European Multiprofessional Training Programme). ERICA has been piloted during the pandemic in seven European centers involving interconnected sectors of professionals working with children and families. The training consisted of interactive modules embedded in a digital learning framework. Different aspects (technology, interaction, and organization) were evaluated and trainers’ feedback on digital features was sought. Technical issues were the main barrier, however, these did not significantly disrupt the training. The trainers perceived reduced interaction between participants, although distinct factors were uncovered as potential favorable mediators. Based on participants’ subjective experiences and perspectives, digital learning frameworks for professionals working with children and families (such as the ERICA model nested in its indispensable adaptation to an e-learning mode) can represent a novel interactive approach to empower trainers and trainees to tackle child maltreatment during critical times such as a pandemic, and as an alternative to more traditional learning frameworks.

Published
2022

35. Pre-discharge predictors of 1-year rehospitalization in adolescents and young adults with severe mental disorders: A retrospective cohort study

Author

Bartoli, F, Cavaleri, D, Moretti, F, Bachi, B, Calabrese, A, Callovini, T, Cioni, R, Riboldi, I, Nacinovich, R, Crocamo, C, Carra, G, Bartoli F., Cavaleri D., Moretti F., Bachi B., Calabrese A., Callovini T., Cioni R. M., Riboldi I., Nacinovich R., Crocamo C., Carra G., Bartoli, F, Cavaleri, D, Moretti, F, Bachi, B, Calabrese, A, Callovini, T, Cioni, R, Riboldi, I, Nacinovich, R, Crocamo, C, Carra, G, Bartoli F., Cavaleri D., Moretti F., Bachi B., Calabrese A., Callovini T., Cioni R. M., Riboldi I., Nacinovich R., Crocamo C., and Carra G.

Abstract

Background and objectives: Readmissions of youths hospitalized for a severe mental disorder are common events and bear a remarkable human, social, and economic burden. The current study aimed at evaluating predictors of 1-year rehospitalization in a sample of adolescents and young adults with severe mental disorders. Materials and Methods: Data for ≤25-year-old inpatients with a severe mental disorder and consecutively admitted between 1 January 2016 and 30 June 2019 were collected. Subjects were retrospectively assessed over a follow-up period of one year after the index discharge to track readmissions—i.e., the primary outcome variable. Standard descriptive statistics were used. The association between variables and 1-year rehospitalization was estimated using the univariate Cox proportional hazards regression model. We then carried out a multivariable Cox regression model, also estimating the covariate-adjusted survivor function. Hazard ratios (HRs) with related 95% confidence intervals (95% CIs) were provided. Results: The final sample included 125 individuals. The multivariable Cox regression model estimated that co-occurring substance use disorders (HR = 2.14; 95% CI: 1.08 to 4.26; p = 0.029) and being admitted for a suicide attempt (HR = 2.49; 95% CI: 1.13 to 5.49; p = 0.024) were both significant predictors of 1-year rehospitalization. Conclusions: Our study showed that comorbid substance use disorders and being admitted for a suicide attempt were predictors of early readmission in youths with severe mental disorders. Although their generalizability is limited, our findings could contribute to improve the quality of young patients’ mental health care by identifying vulnerable subjects who may benefit from tailored interventions to prevent rehospitalizations.

Published
2020

37. Effects of experimental reheating of natural basaltic ash at different temperatures and redox conditions

Author

D'Oriano, C., Pompilio, M., Bertagnini, A., Cioni, R., and Pichavant, M.

Subjects
Basalt, Earth sciences
Abstract

A set of experiments have been performed on volcanic materials from Etna, Stromboli and Vesuvius in order to evaluate how the exposure to thermal and redox conditions close to that of active craters affects the texture and composition of juvenile pyroclasts. Selected samples were placed within a quartz tube, in presence of air or under vacuum, and kept at T between 700 and 1,130°C, for variable time (40 min to 12 h). Results show that reheating reactivates the melt, which, through processes of chemical and thermal diffusion, reaches new equilibrium conditions. In all the experiments performed at T = 700-750°C, a large number of crystal nuclei and spherulites grows in the groundmass, suggesting conditions of high undercooling. This process creates textural heterogeneities at the scale of few microns but only limited changes of groundmass composition, which remains clustered around that of the natural glasses. Reheating at T = 1,000-1,050°C promotes massive groundmass crystallization, with a different mineral assemblage as a function of the redox conditions. Morphological modifications of clasts, from softening to sintering as temperature increases, occur under these conditions, accompanied by progressive smoothing of external surfaces, and a reduction in size and abundance of vesicles, until the complete obliteration of the pre-existing vesicularity. The transition from sintering to welding, characteristic of high temperature, is influenced by redox conditions. Experiments at T = 1,100-1,130°C and under vacuum produce groundmass textures and glass compositions similar to that of the respective starting material. Collapse and welding of the clasts cause significant densification of the whole charge. At the same temperature, but in presence of air, experimental products at least result sintered and show holocrystalline groundmass. In all experiments, sublimates grow on the external surfaces of the clasts or form a lining on the bubble walls. Their shape and composition is a function of temperature and f[O.sub.2] and the abundance of sublimates shows a peak at 1,000°C. The identification of the features recorded by pyroclasts during complex heating-cooling cycles allows reconstructing the complete clasts history before their final emplacement, during weakly explosive volcanic activity. This has a strong implication on the characterization of primary juvenile material and on the interpretation of eruption dynamics. Keywords Volcanic ash * Basalts * Etna * Stromboli * Vesuvius * Alteration * Crystallization * Experiments * Reheating, Introduction Weakly explosive eruptions produce a large range of volcanic products varying from bombs to fine ash (Cioni et al. 2010). Depending on the energy of each eruption, a large [...]

Published
2013
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46. Upward migration of Vesuvius magma chamber over the past 20,000 years

Author

Scaillet, B., Pichavant, M., and Cioni, R.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Forecasting future eruptions of Vesuvius is an important challenge for volcanologists, as its reawakening could threaten the lives of 700,000 people living near the volcano (1,2). Critical to the evaluation [...]

Published
2008

47. Some of us are most at risk: Systematic Review and Meta-Analysis of correlates of depressive symptoms among healthcare workers during the SARS-CoV-2 outbreak

Author

Crocamo, C, Bachi, B, Calabrese, A, Callovini, T, Cavaleri, D, Cioni, R, Moretti, F, Bartoli, F, Carrà, G, Crocamo, Cristina, Bachi, Bianca, Calabrese, Angela, Callovini, Tommaso, Cavaleri, Daniele, Cioni, Riccardo M., Moretti, Federico, Bartoli, Francesco, Carrà, Giuseppe, Crocamo, C, Bachi, B, Calabrese, A, Callovini, T, Cavaleri, D, Cioni, R, Moretti, F, Bartoli, F, Carrà, G, Crocamo, Cristina, Bachi, Bianca, Calabrese, Angela, Callovini, Tommaso, Cavaleri, Daniele, Cioni, Riccardo M., Moretti, Federico, Bartoli, Francesco, and Carrà, Giuseppe

Abstract

The COVID-19 pandemic has had a severe psychosocial impact on healthcare workers (HCWs). This systematic review and meta-analysis aimed at evaluating the association between individual features and depressive symptoms reported by HCWs during the pandemic. We searched Medline, Embase, and PsycInfo up to 23 June 2020. We included cross-sectional studies testing the association between individual correlates and depressive symptoms in HCWs during the SARS-CoV-2 outbreak. Fourteen studies met inclusion criteria, involving 14,173 HCWs (3,070 with depressive symptoms). Women (OR = 1.50; 95 %CI: 1.28–1.76; I2 = 40.0 %), individuals with suspected/confirmed COVID-19 (OR = 2.10; 95 %CI: 1.64–2.69; I2 = 0 %), and those with an infected family member or friend (OR = 1.67; 95 %CI: 1.37–2.04; I2 = 0%) were more likely to report depressive features, which, instead, were less frequent among doctors (compared with nurses) (OR = 0.80; 95 %CI: 0.66–0.98; I2 = 48.2 %) and HCWs who felt adequately protected (OR = 0.48; 95 %CI: 0.32–0.72; I2 = 36.3 %). Our study provided timely evidence on the correlates of depressive symptoms among HCWs during the pandemic. Early screening is crucial to develop tailored health interventions, redesigning the response to COVID-19.

Published
2021

48. Standardizing percutaneous Microwave Ablation in the treatment of Lung Tumors: a prospective multicenter trial (MALT study)

Author

Iezzi, Roberto, Cioni, R., Basile, D., Tosoratti, N., Posa, A., Busso, M., Cappelli, C., Margaritora, Stefano, Ambrogi, M. C., Cassano, Alessandra, Scandiffio, R., Calandri, M., Crocetti, L., Valentini, Vincenzo, Manfredi, Riccardo, Veltri, A., Iezzi R. (ORCID:0000-0002-2791-481X), Margaritora S. (ORCID:0000-0002-9796-760X), Cassano A. (ORCID:0000-0002-3311-7163), Valentini V. (ORCID:0000-0003-4637-6487), Manfredi R. (ORCID:0000-0002-4972-9500), Iezzi, Roberto, Cioni, R., Basile, D., Tosoratti, N., Posa, A., Busso, M., Cappelli, C., Margaritora, Stefano, Ambrogi, M. C., Cassano, Alessandra, Scandiffio, R., Calandri, M., Crocetti, L., Valentini, Vincenzo, Manfredi, Riccardo, Veltri, A., Iezzi R. (ORCID:0000-0002-2791-481X), Margaritora S. (ORCID:0000-0002-9796-760X), Cassano A. (ORCID:0000-0002-3311-7163), Valentini V. (ORCID:0000-0003-4637-6487), and Manfredi R. (ORCID:0000-0002-4972-9500)

Abstract

Objectives: To prospectively assess reproducibility, safety, and efficacy of microwave ablation (MWA) in the treatment of unresectable primary and secondary pulmonary tumors. Methods: Patients with unresectable primary and metastatic lung tumors up to 4 cm were enrolled in a multicenter prospective clinical trial and underwent CT-guided MWA. Treatments were delivered using pre-defined MW power and duration settings, based on target tumor size and histology classifications. Patients were followed for up to 24 months. Treatment safety, efficacy, and reproducibility were assessed. Ablation volumes were measured at CT scan and compared with ablation volumes obtained on ex vivo bovine liver using equal treatment settings. Results: From September 2015 to September 2017, 69 MWAs were performed in 54 patients, achieving technical success in all cases and treatment completion without deviations from the standardized protocol in 61 procedures (88.4%). Immediate post-MWA CT scans showed ablation dimensions smaller by about 25% than in the ex vivo model; however, a remarkable volumetric increase (40%) of the treated area was observed at 1 month post-ablation. No treatment-related deaths nor complications were recorded. Treatments of equal power and duration yielded fairly reproducible ablation dimensions at 48-h post-MWA scans. In comparison with the ex vivo liver model, in vivo ablation sizes were systematically smaller, by about 25%. Overall LPR was 24.7%, with an average TLP of 8.1 months. OS rates at 12 and 24 months were 98.0% and 71.3%, respectively. Conclusions: Percutaneous CT-guided MWA is a reproducible, safe, and effective treatment for malignant lung tumors up to 4 cm in size. Key Points: • Percutaneous MWA treatment of primary and secondary lung tumors is a repeatable, safe, and effective therapeutic option. • It provides a fairly reproducible performance on both the long and short axis of the ablation zone. • When using pre-defined treatment duration and power set

Published
2021

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