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Secretory carcinoma (SC) is a rare recently described entity that has characteristics similar to those of secretory breast carcinoma. We report a case of a 23 years old male with a swelling on the parotid gland. The ultrasonography guided fine needle aspiration cytology was performed on mass. Cytologically, the background of the aspirate is composed of inflammatory cells admixed with mucinous material. There were isolated cells as much as loosely cohesive clusters making papillary follicle-like glands with eosinophilic material in the lumen. Tumor cells were medium-sized round shape and eccentric nuclei with prominent nucleoli, remarkably vacuolated cytoplasm. The parotidectomy was per- formed and the pathology report revealed a SC. Histologically, the tumor is composed of microcystic, follicular, and micropapillary areas. The cytoplasm is usually vacuolated with also clear eosinophilic appearance. Immunohistochemically, tumor cells labeled with S100, MUC-4. At 5 years, the patient is disease-free and under regular follow-up.

Objective: Studies have been performed on many biomolecules to determine the prognosis of LSCC and predict the course of the disease. However, a molecular marker that can be used clinically has not yet been found. Therefore, in this study, we aimed to investigate the expression levels of LRIG 1 in laryngeal cancer.Materials and Methods: In our study, 219 cases who underwent surgery due to LSCC and 88 randomly selected patients whose pathologic result were benign and premalignant lesions in Marmara University Pendik Education and Research Hospital between 2003 and 2018 were analyzed. Patients’ data were obtained from the medical records. The tissue microarray method was used to evaluate specimens.Results: There was a statistically significant difference between the tumor differentiation, diagnosis, and the expression of LRIG1 (respectively p=0.045, p

Objective: Trichoblastomas are rare benign tumors of the skin appendages with epithelial and mesenchymal components that exhibit differentiation to the follicular germinative epithelium and particularly to the follicular stroma of the skin. Our aim was to contribute to already limited literature data in order to gain more insights into the treatment and follow-up of patients with this condition. Methods and Materials: A total of 9 patients with trichoblastoma and 1 patient with malignant trichoblastoma were surgically treated between 2016 and 2020 at the Department of Plastic, Reconstructive and Aesthetic Surgery, School of Medicine, Marmara University. Results: Of the 10 patients with trichoblastoma, 5 were female and 5 were male, with a median age of 49 years. The smallest and largest lesion lenghts were 0.4 and 2 cm, respectively. Seven lesions had developed in the head and neck region, while 2 were in the trunk. One of our cases was a 45-year old female patient with a malignant trichoblastoma presented with a lesion in the right side of the lower lip. Conclusion: Trichoblastomas are rare tumors that affect both sexes equally and are seen most commonly in the head and neck region. Recurrence rates were found to be low when they were treated with negative surgical margins.