22 results on '"Cindy Mai"'
Search Results
2. Parameters predicting [18F]PSMA-1007 scan positivity and type and number of detected lesions in patients with biochemical recurrence of prostate cancer
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Niloefar Ahmadi Bidakhvidi, Annouschka Laenen, Sander Jentjens, Christophe M. Deroose, Koen Van Laere, Liesbeth De Wever, Cindy Mai, Charlien Berghen, Gert De Meerleer, Karin Haustermans, Steven Joniau, Wouter Everaerts, and Karolien Goffin
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[18F]PSMA-1007-PET/CT ,Biochemical recurrence ,Lesion-type ,Prostate cancer ,PSA ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Background Detection of the site of recurrence using PSMA-PET/CT is important to guide treatment in patients with biochemical recurrence of prostate cancer (PCa). The aim of this study was to evaluate the positivity rate of [18F]PSMA-1007-PET/CT in patients with biochemically recurrent PCa and identify parameters that predict scan positivity as well as the type and number of detected lesions. This monocentric retrospective study included 137 PCa patients with biochemical recurrence who underwent one or more [18F]PSMA-1007-PET/CT scans between August 2018 and June 2019. PET-positive malignant lesions were classified as local recurrence, lymph node (LN), bone or soft tissue lesions. The association between biochemical/paraclinical parameters, as PSA value, PSA doubling time, PSA velocity, Gleason score (GS) and androgen deprivation therapy (ADT), and scan positivity as well as type and number of detected lesions was evaluated using logistic regression analysis (binary outcomes) and Poisson models (count-type outcomes). Results We included 175 [18F]PSMA-1007-PET/CT scans after radical prostatectomy (78%), external beam radiation therapy (8.8%), ADT (7.3%), brachytherapy (5.1%) and high intensity focused ultrasound (0.7%) as primary treatment (median PSA value 1.6 ng/ml). Positivity rate was 80%. PSA value and PSA velocity were significant predictors of scan positivity as well as of the presence of bone and soft tissue lesions and number of bone, LN and soft tissue lesions, both in uni- and/or multivariable analysis. Multivariable analysis also showed prior ADT as predictor of bone and soft tissue lesions, GS as predictor of the number of bone lesions and ongoing ADT as predictor of the number of LN lesions. Conclusion [18F]PSMA-1007-PET/CT showed a high positivity rate in patients with biochemically recurrent PCa. PSA value and PSA velocity were significant predictors of scan positivity as well as of the presence and number of bone and soft tissue lesions and the number of LN lesions. Our findings can guide clinicians in optimal patient selection for [18F]PSMA-1007-PET/CT and support further research leading to the development of a prediction nomogram.
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- 2021
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3. Effects of Prenatal Exposure to Alcohol and Smoking on Fetal Heart Rate and Movement Regulation
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Maristella Lucchini, Lauren C. Shuffrey, J. David Nugent, Nicoló Pini, Ayesha Sania, Margaret Shair, Lucy Brink, Carlie du Plessis, Hein J. Odendaal, Morgan E. Nelson, Christa Friedrich, Jyoti Angal, Amy J. Elliott, Coen A. Groenewald, Larry T. Burd, Michael M. Myers, William P. Fifer, Gary DV Hankins, Kimberly A Dukes, Lisa M Sullivan, Tara Tripp, Fay Robinson, Cheri Raffo, Julie M Petersen, Rebecca A Young, Cindy Mai, Elena Grillo, Travis Baker, Gregory Toland, Michael Carmen, Hannah C Kinney, Robin L Haynes, Rebecca D Folkerth, Ingrid A Holm, Theonia Boyd, David S Paterson, Hanno Steen, Kyriacos Markianos, Drucilla Roberts, Kevin G Broadbelt, Richard G Goldstein, Laura L. Nelsen, Jacob Cotton, Perri Jacobs, Amy J Elliott, Larr Burd, Jessica Gromer, H Eugene Hoyme, Margaret Jackson, Luke Mack, Bradley B Randall, Mary Ann Sens, Deborah Tobacco, Peter Van Eerden, Hendrik Odendaal, Colleen Wright, Lut Geerts, Greetje de Jong, Pawel Schubert, Shabbir Wadee, Johan Dempers, Elsie Burger, Janetta Harbron, Coen Groenewald, William Fifer, Michael Myers, Joseph Isler, Yvonne Sininger, J David Nugent, Carmen Condon, Margaret C Shair, Tracy Thai, Marian Willinger, Dale Hereld, Howard J Hoffman, and Chuan-Ming Li
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fetal heart rate ,fetal movement ,autonomic nervous system ,prenatal ,alcohol ,smoking ,Physiology ,QP1-981 - Abstract
Negative associations of prenatal tobacco and alcohol exposure (PTE and PAE) on birth outcomes and childhood development have been well documented, but less is known about underlying mechanisms. A possible pathway for the adverse fetal outcomes associated with PTE and PAE is the alteration of fetal autonomic nervous system development. This study assessed PTE and PAE effects on measures of fetal autonomic regulation, as quantified by heart rate (HR), heart rate variability (SD-HR), movement, and HR-movement coupling in a population of fetuses at ≥ 34 weeks gestational age. Participants are a subset of the Safe Passage Study, a prospective cohort study that enrolled pregnant women from clinical sites in Cape Town, South Africa, and the Northern Plains region, United States. PAE was defined by six levels: no alcohol, low quit early, high quit early, low continuous, moderate continuous, and high continuous; while PTE by 4 levels: no smoking, quit early, low continuous, and moderate/high continuous. Linear regression analyses of autonomic measures were employed controlling for fetal sex, gestational age at assessment, site, maternal education, household crowding, and depression. Analyses were also stratified by sleep state (1F and 2F) and site (South Africa, N = 4025, Northern Plains, N = 2466). The final sample included 6491 maternal-fetal-dyad assessed in the third trimester [35.21 ± 1.26 (mean ± SD) weeks gestation]. PTE was associated with a decrease in mean HR in state 2F, in a dose dependent fashion, only for fetuses of mothers who continued smoking after the first trimester. In state 1F, there was a significant increase in mean HR in fetuses whose mother quit during the first trimester. This effect was driven by the Norther Plains cohort. PTE was also associated with a significant reduction in fetal movement in the most highly exposed group. In South Africa a significant increase in mean HR both for the high quit early and the high continuous group was observed. In conclusion, this investigation addresses a critical knowledge gap regarding the relationship between PTE and PAE and fetal autonomic regulation. We believe these results can contribute to elucidating mechanisms underlying risk for adverse outcomes.
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- 2021
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4. An Unusual Presentation of Congenital Esophageal Stenosis Due to Tracheobronchial Remnants in a Newborn Prenatally Diagnosed with Duodenal Atresia
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Cindy Mai, Luc Breysem, Gert De Hertogh, Dirk Van Raemdonck, and Maria-Helena Smet
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Esophageal stenosis, Constriction, Duodenal obstruction, Infant ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Congenital esophageal stenosis due to tracheobronchial remnants is defined as an intrinsic stenosis of the esophagus caused by congenital architectural abnormalities of the esophageal wall. Although CES is present at birth, it remains asymptomatic till at the age of 4–10 months, when solid food is introduced. Here we present a case diagnosed in the neonatal period after urgent cesarean for an associated duodenal atresia complicated with perforation. There is a mutual association between duodenal atresia and congenital esophageal stenosis. When duodenal atresia is diagnosed, think of possible associated esophageal abnormalities, especially when duodenal atresia is complicated by gastric perforation prenatally.
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- 2015
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5. PD61-05 ONCOLOGICAL OUTCOMES OF NEOADJUVANT DEGARELIX WITH APALUTAMIDE (ARNEO TRIAL) VERSUS STANDARD OF CARE PRIOR TO RADICAL PROSTATECTOMY FOR HIGH-RISK PROSTATE CANCER: A PROPENSITY SCORE MATCHED ANALYSIS
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Giesen, Alexander, primary, Devos, Gaëtan, additional, Tosco, Lorenzo, additional, Baldewijns, Marcella, additional, Gevaert, Thomas, additional, Goffin, Karolien, additional, Valentin, Petit, additional, Cindy, Mai, additional, Yannic, Raskin, additional, Carl, Van Haute, additional, Goeman, Lieven, additional, Gert, De Meerleer, additional, Charlien, Berghen, additional, Wout, Devlies, additional, Frank, Claessens, additional, Hendrik, Van Poppel, additional, Wouter, Everaerts, additional, and Steven, Joniau, additional
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- 2024
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6. PD42-08 CAN WE USE IMMUNOHISTOCHEMISTRY AS PREDICTING FACTOR OF SUCCESSFUL TREATMENT WITH INTENSIFIED NEOADJUVANT TREATMENT IN HIGH-RISK PROSTATE CANCER: A SUBANALYSIS OF THE ARNEO TRIAL?
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Giesen, Alexander, primary, Devos, Gaëtan, additional, Tosco, Lorenzo, additional, Baldewijns, Marcella, additional, Gevaert, Thomas, additional, Goffin, Karolien, additional, Valentin, Petit, additional, Cindy, Mai, additional, Yannic, Raskin, additional, Carl, Van Haute, additional, Goeman, Lieven, additional, Gert, De Meerleer, additional, Charlien, Berghen, additional, Wout, Devlies, additional, Frank, Claessens, additional, Hendrik, Van Poppel, additional, Wouter, Everaerts, additional, and Steven, Joniau, additional
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- 2024
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7. Prospective comparison of simultaneous [68Ga]Ga-PSMA-11 PET/MR versus PET/CT in patients with biochemically recurrent prostate cancer
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Raymond Oyen, Michel Koole, Nathalie Mertens, Wouter Everaerts, Liesbeth De Coster, Cindy Mai, Koen Van Laere, Niloefar Ahmadi Bidakhvidi, Sander Jentjens, Steven Joniau, and Karolien Goffin
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Biochemical recurrence ,PET-CT ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Ultrasound ,Interventional radiology ,General Medicine ,Lesion ,medicine.anatomical_structure ,Medicine ,Radiology, Nuclear Medicine and imaging ,In patient ,Radiology ,medicine.symptom ,business ,Lymph node ,Neuroradiology - Abstract
PSMA-PET has become the PET technique of choice to localise the site of biochemically recurrent prostate cancer (PCa). With hybrid PET/MRI, the advantages of MRI are added to molecular characteristic of PET. The aim of this study was to investigate the incremental value of PET/MR versus PET/CT in patients with biochemically recurrent PCa by head-to-head comparison. Thirty-four patients with biochemically recurrent PCa were prospectively included. They underwent [68Ga]Ga-PSMA-11 PET/CT, followed by simultaneous PET/MR. All PET (PETCT, PETMR), CT and MR images were evaluated for number of lesions and location. The number of lesions at specific sites was compared using Wilcoxon-sign-rank test. For PET, the maximum and mean standardised uptake values (SUVs) were calculated for each lesion compared using a two-sided paired t test. PETCT and PETMR scans were positive in 19 and 20 patients, detecting 73 and 79 lesions respectively. All lesions detected on PETCT were also detected on PETMR. CT and MRI only were positive in 14 and 17 patients, detecting 38 and 50 lesions, respectively, which was significantly lower than PETCT and PETMR respectively. Combined interpretation showed more lesions on PET/MR than on PET/CT (88 vs 81). No significant difference in detection of presence of local recurrence nor distant metastases was found. SUVmean and SUVmax values were significantly higher on PETMR than on PETCT in local recurrence and lymph node metastases. [68Ga]Ga-PSMA-11 PET/MR was able to detect biochemically recurrent PCa at least as accurately as PET/CT for local recurrence, lymph node metastasis and distant metastasis. • PSMA PET/MRI detects the location of biochemical recurrence at least as accurately as PET/CT. • Substitution of PET/CT by PET/MRI adds sensitivity in PSMA lesion detection also in the setting of distant recurrence due to both the MR and TOF PET components.
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- 2021
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8. Ga-68-PSMA-11 PET, F-18-PSMA-1007 PET, and MRI for Gross Tumor Volume Delineation in Primary Prostate Cancer: Intermodality and Intertracer Variability
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Marloes van der Leest, Gilles Defraene, Linda G W Kerkmeijer, Sofie Isebaert, Robert Jan Smeenk, Raymond Oyen, Uulke A. van der Heide, Steven Joniau, Frederik Maes, Wouter V. Vogel, Robin De Roover, Karolien Goffin, Cindy Mai, Cédric Draulans, M. Kunze-Busch, Karin Haustermans, Marcel J.R. Janssen, Floris J. Pos, Patrik Zamecnik, Stijn W.T.P.J. Heijmink, and James Nagarajah
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medicine.medical_treatment ,030218 nuclear medicine & medical imaging ,68Ga-PSMA-11 ,03 medical and health sciences ,Prostate cancer ,All institutes and research themes of the Radboud University Medical Center ,0302 clinical medicine ,Interquartile range ,Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14] ,medicine ,Radiology, Nuclear Medicine and imaging ,Index Lesion ,medicine.diagnostic_test ,business.industry ,Prostatectomy ,Other Research Radboud Institute for Health Sciences [Radboudumc 0] ,Magnetic resonance imaging ,medicine.disease ,Gross tumor volume ,Oncology ,Positron emission tomography ,Urological cancers Radboud Institute for Health Sciences [Radboudumc 15] ,030220 oncology & carcinogenesis ,business ,Nuclear medicine ,Rare cancers Radboud Institute for Health Sciences [Radboudumc 9] - Abstract
PURPOSE: To assess the intermodality and intertracer variability of gallium-68 (68Ga)- or fluorine-18 (18F)-labeled prostate-specific membrane antigen (PSMA) positron emission tomography (PET) and biparametric magnetic resonance imaging (bpMRI)-based gross tumor volume (GTV) delineation for focal boosting in primary prostate cancer. METHODS: Nineteen prospectively enrolled patients with prostate cancer underwent a PSMA PET/MRI scan, divided into a 1:1 ratio between 68Ga-PSMA-11 and 18F-PSMA-1007, before radical prostatectomy (IWT140193). Four delineation teams performed manual contouring of the GTV based on bpMRI and PSMA PET imaging, separately. Index lesion coverage (overlap%) and interobserver variability were assessed. Furthermore, the distribution of the voxelwise normalized standardized uptake values (SUV%) was determined for the majority-voted (>50%) GTV (GTVmajority) and whole prostate gland to investigate intertracer variability. The median patientwise SUV% contrast ratio (SUV%-CR, calculated as median GTVmajority SUV% / median prostate gland without GTVmajority SUV%) was calculated according to the tracer used. RESULTS: A significant difference in overlap% favoring PSMA PET compared with bpMRI was found in the 18F subgroup (median, 63.0% vs 53.1%; P = .004) but was not present in the 68Ga subgroup (32.5% vs 50.6%; P = .100). Regarding interobserver variability, measured Sørensen-Dice coefficients (0.58 vs 0.72) and calculated mean distances to agreement (2.44 mm vs 1.22 mm) were statistically significantly lower and higher, respectively, for the 18F cohort compared with the 68Ga cohort. For the bpMRI-based delineations, the median Sørensen-Dice coefficient and mean distance to agreement were 0.63 and 1.76 mm, respectively. Median patientwise SUV%-CRs of 1.8 (interquartile range [IQR], 1.6-2.7) for 18F-PSMA and 3.3 (IQR, 2.7-5.9) for 68Ga-PSMA PET images were found. CONCLUSIONS: Both MRI and PSMA PET provided consistent intraprostatic GTV lesion detection. However, the PSMA tracer seems to have a major influence on the contour characteristics, owing to an apparent difference in SUV% distribution in the prostate gland. ispartof: PRACTICAL RADIATION ONCOLOGY vol:11 issue:3 pages:202-211 ispartof: location:United States status: published
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- 2021
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9. Optimal 68Ga-PSMA and 18F-PSMA PET window levelling for gross tumour volume delineation in primary prostate cancer
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Karolien Goffin, Uulke A. van der Heide, Steven Joniau, Linda G W Kerkmeijer, Raymond Oyen, M. Kunze-Busch, Sofie Isebaert, Robert Jan Smeenk, Cindy Mai, Frederik Maes, James Nagarajah, Karin Haustermans, Cédric Draulans, Marcel J.R. Janssen, Floris J. Pos, Wouter V. Vogel, and Robin De Roover
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PSMA PET ,Gross tumour volume ,computer.software_genre ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,FAILURES ,Voxel ,Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14] ,DOSE-ESCALATION ,Medicine ,Radiology, Nuclear Medicine and imaging ,Contouring ,Science & Technology ,Radiotherapy ,Receiver operating characteristic ,business.industry ,Radiology, Nuclear Medicine & Medical Imaging ,Curve analysis ,68ga psma ,Delineation ,Focal boost ,General Medicine ,medicine.disease ,Urological cancers Radboud Institute for Health Sciences [Radboudumc 15] ,030220 oncology & carcinogenesis ,Psma pet ,Prostatic neoplasms ,business ,Nuclear medicine ,Life Sciences & Biomedicine ,computer ,Rare cancers Radboud Institute for Health Sciences [Radboudumc 9] - Abstract
Contains fulltext : 235315.pdf (Publisher’s version ) (Closed access) PURPOSE: This study proposes optimal tracer-specific threshold-based window levels for PSMA PET-based intraprostatic gross tumour volume (GTV) contouring to reduce interobserver delineation variability. METHODS: Nine (68)Ga-PSMA-11 and nine (18)F-PSMA-1007 PET scans including GTV delineations of four expert teams (GTV(manual)) and a majority-voted GTV (GTV(majority)) were assessed with respect to a registered histopathological GTV (GTV(histo)) as the gold standard reference. The standard uptake values (SUVs) per voxel were converted to a percentage (SUV%) relative to the SUV(max). The statistically optimised SUV% threshold (SOST) was defined as those that maximises accuracy for threshold-based contouring. A leave-one-out cross-validation receiver operating characteristic (ROC) curve analysis was performed to determine the SOST for each tracer. The SOST analysis was performed twice, first using the GTV(histo) contour as training structure (GTV(SOST-H)) and second using the GTV(majority) contour as training structure (GTV(SOST-MA)) to correct for any limited misregistration. The accuracy of both GTV(SOST-H) and GTV(SOST-MA) was calculated relative to GTV(histo) in the 'leave-one-out' patient of each fold and compared with the accuracy of GTV(manual). RESULTS: ROC curve analysis for (68)Ga-PSMA-11 PET revealed a median threshold of 25 SUV% (range, 22-27 SUV%) and 41 SUV% (40-43 SUV%) for GTV(SOST-H) and GTV(SOST-MA), respectively. For (18)F-PSMA-1007 PET, a median threshold of 42 SUV% (39-45 SUV%) for GTV(SOST-H) and 44 SUV% (42-45 SUV%) for GTV(SOST-MA) was found. A significant pairwise difference was observed when comparing the accuracy of the GTV(SOST-H) contours with the median accuracy of the GTV(manual) contours (median, - 2.5%; IQR, - 26.5-0.2%; p = 0.020), whereas no significant pairwise difference was found for the GTV(SOST-MA) contours (median, - 0.3%; IQR, - 4.4-0.6%; p = 0.199). CONCLUSIONS: Threshold-based contouring using GTV(majority)-trained SOSTs achieves an accuracy comparable with manual contours in delineating GTV(histo). The median SOSTs of 41 SUV% for (68)Ga-PSMA-11 PET and 44 SUV% for (18)F-PSMA-1007 PET form a base for tracer-specific window levelling. TRIAL REGISTRATION: Clinicaltrials.gov ; NCT03327675; 31-10-2017.
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- 2020
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10. ARNEO: A Randomized Phase II Trial of Neoadjuvant Degarelix with or Without Apalutamide Prior to Radical Prostatectomy for High-risk Prostate Cancer
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Gaëtan Devos, Lorenzo Tosco, Marcella Baldewijns, Thomas Gevaert, Karolien Goffin, Valentin Petit, Cindy Mai, Annouschka Laenen, Yannic Raskin, Carl Van Haute, Lieven Goeman, Gert De Meerleer, Charlien Berghen, Wout Devlies, Frank Claessens, Hendrik Van Poppel, Wouter Everaerts, and Steven Joniau
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Urology - Abstract
High-risk prostate cancer (PCa) patients have a high risk of biochemical recurrence and metastatic progression following radical prostatectomy (RP).To determine the efficacy of neoadjuvant degarelix plus apalutamide before RP compared with degarelix with a matching placebo.ARNEO was a randomized, placebo-controlled, phase II neoadjuvant trial before RP performed between March 2019 and April 2021. Eligible patients had high-risk PCa and were amenable to RP.Patients were randomly assigned at a 1:1 ratio to degarelix (240-80-80 mg) + apalutamide (240 mg/d) versus degarelix + matching placebo for 3 mo followed by RP. Prior to and following neoadjuvant treatment, pelvicThe primary endpoint was the difference in proportions of patients with minimal residual disease (MRD; = residual cancer burden (RCB) ≤0.25 cmPatients were randomized to neoadjuvant degarelix + apalutamide (n = 45) or degarelix + matching placebo (n = 44) for 12 wk and underwent RP. Patients in the degarelix + apalutamide arm achieved a significantly higher rate of MRD than those in the control arm (38% vs 9.1%; relative risk [95% confidence interval] = 4.2 [1.5-11], p = 0.002). Patients with PTEN loss in baseline prostate biopsy attained significantly less MRD (11% vs 43%, p = 0.002) and had a higher RCB at final pathology (1.6 vs 0.40 cmIn high-risk PCa patients, neoadjuvant degarelix plus apalutamide prior to RP results in a significantly improved pathological response (MRD and RCB) compared with degarelix alone. Our trial results provide a solid hypothesis-generating basis for neoadjuvant phase 3 trials, which are powered to detect differences in long-term oncological outcome following neoadjuvant androgen receptor signaling inhibitor therapy.In this study, we looked at the difference in pathological responses in high-risk prostate cancer patients treated with degarelix plus apalutamide or degarelix plus matching placebo prior to radical prostatectomy. We demonstrated that patients treated with degarelix plus apalutamide achieved a significantly better tumor response than patients treated with degarelix plus matching placebo. Long-term follow-up is required to determine whether improved pathological outcome translates into better oncological outcomes.
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- 2022
11. Parameters predicting [18F]PSMA-1007 scan positivity and type and number of detected lesions in patients with biochemical recurrence of prostate cancer
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Wouter Everaerts, Niloefar Ahmadi Bidakhvidi, Cindy Mai, Charlien Berghen, Gert De Meerleer, Karin Haustermans, Koen Van Laere, Karolien Goffin, Annouschka Laenen, Sander Jentjens, Steven Joniau, Christophe Deroose, and Liesbeth De Wever
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Biochemical recurrence ,medicine.medical_specialty ,medicine.medical_treatment ,Brachytherapy ,R895-920 ,urologic and male genital diseases ,030218 nuclear medicine & medical imaging ,Androgen deprivation therapy ,03 medical and health sciences ,Prostate cancer ,Medical physics. Medical radiology. Nuclear medicine ,PSA ,0302 clinical medicine ,medicine ,Lesion-type ,Radiology, Nuclear Medicine and imaging ,Original Research ,PSA Velocity ,Prostatectomy ,business.industry ,Soft tissue ,[F-18]PSMA-1007-PET ,Nomogram ,medicine.disease ,030220 oncology & carcinogenesis ,[18F]PSMA-1007-PET/CT ,Radiology ,business ,CT - Abstract
Background Detection of the site of recurrence using PSMA-PET/CT is important to guide treatment in patients with biochemical recurrence of prostate cancer (PCa). The aim of this study was to evaluate the positivity rate of [18F]PSMA-1007-PET/CT in patients with biochemically recurrent PCa and identify parameters that predict scan positivity as well as the type and number of detected lesions. This monocentric retrospective study included 137 PCa patients with biochemical recurrence who underwent one or more [18F]PSMA-1007-PET/CT scans between August 2018 and June 2019. PET-positive malignant lesions were classified as local recurrence, lymph node (LN), bone or soft tissue lesions. The association between biochemical/paraclinical parameters, as PSA value, PSA doubling time, PSA velocity, Gleason score (GS) and androgen deprivation therapy (ADT), and scan positivity as well as type and number of detected lesions was evaluated using logistic regression analysis (binary outcomes) and Poisson models (count-type outcomes). Results We included 175 [18F]PSMA-1007-PET/CT scans after radical prostatectomy (78%), external beam radiation therapy (8.8%), ADT (7.3%), brachytherapy (5.1%) and high intensity focused ultrasound (0.7%) as primary treatment (median PSA value 1.6 ng/ml). Positivity rate was 80%. PSA value and PSA velocity were significant predictors of scan positivity as well as of the presence of bone and soft tissue lesions and number of bone, LN and soft tissue lesions, both in uni- and/or multivariable analysis. Multivariable analysis also showed prior ADT as predictor of bone and soft tissue lesions, GS as predictor of the number of bone lesions and ongoing ADT as predictor of the number of LN lesions. Conclusion [18F]PSMA-1007-PET/CT showed a high positivity rate in patients with biochemically recurrent PCa. PSA value and PSA velocity were significant predictors of scan positivity as well as of the presence and number of bone and soft tissue lesions and the number of LN lesions. Our findings can guide clinicians in optimal patient selection for [18F]PSMA-1007-PET/CT and support further research leading to the development of a prediction nomogram.
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- 2021
12. Prospective comparison of simultaneous [
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Sander, Jentjens, Cindy, Mai, Niloefar, Ahmadi Bidakhvidi, Liesbeth, De Coster, Nathalie, Mertens, Michel, Koole, Wouter, Everaerts, Steven, Joniau, Raymond, Oyen, Koen, Van Laere, and Karolien, Goffin
- Subjects
Male ,Positron Emission Tomography Computed Tomography ,Humans ,Prostatic Neoplasms ,Gallium Radioisotopes ,Prospective Studies ,Magnetic Resonance Imaging ,Oligopeptides ,Edetic Acid - Abstract
PSMA-PET has become the PET technique of choice to localise the site of biochemically recurrent prostate cancer (PCa). With hybrid PET/MRI, the advantages of MRI are added to molecular characteristic of PET. The aim of this study was to investigate the incremental value of PET/MR versus PET/CT in patients with biochemically recurrent PCa by head-to-head comparison.Thirty-four patients with biochemically recurrent PCa were prospectively included. They underwent [PET[• PSMA PET/MRI detects the location of biochemical recurrence at least as accurately as PET/CT. • Substitution of PET/CT by PET/MRI adds sensitivity in PSMA lesion detection also in the setting of distant recurrence due to both the MR and TOF PET components.
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- 2021
13. Optimal
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Cédric, Draulans, Robin, De Roover, Uulke A, van der Heide, Linda, Kerkmeijer, Robert J, Smeenk, Floris, Pos, Wouter V, Vogel, James, Nagarajah, Marcel, Janssen, Sofie, Isebaert, Frederik, Maes, Cindy, Mai, Raymond, Oyen, Steven, Joniau, Martina, Kunze-Busch, Karolien, Goffin, and Karin, Haustermans
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Male ,Positron Emission Tomography Computed Tomography ,Humans ,Prostatic Neoplasms ,Gallium Radioisotopes ,Oligopeptides ,Edetic Acid ,Gallium Isotopes ,Tumor Burden - Abstract
This study proposes optimal tracer-specific threshold-based window levels for PSMA PET-based intraprostatic gross tumour volume (GTV) contouring to reduce interobserver delineation variability.NineROC curve analysis forThreshold-based contouring using GTVClinicaltrials.gov ; NCT03327675; 31-10-2017.
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- 2020
14. Drinking and smoking patterns during pregnancy: Development of group-based trajectories in the Safe Passage Study
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Kimberly Dukes, Tara Tripp, Marian Willinger, Hein Odendaal, Amy J. Elliott, Hannah C. Kinney, Fay Robinson, Julie M. Petersen, Cheryl Raffo, Dale Hereld, Coen Groenewald, Jyoti Angal, Gary Hankins, Larry Burd, William P. Fifer, Michael M. Myers, Howard J. Hoffman, Lisa Sullivan, Gary D.V. Hankins, Kimberly A. Dukes, Lisa M. Sullivan, Cheri Raffo, Rebecca A. Young, Cindy Mai, Elena Grillo, Travis Baker, Patti Folan, Gregory Toland, Michael Carmen, Robin L. Haynes, Rebecca D. Folkerth, Ingrid A. Holm, Theonia Boyd, David S. Paterson, Hanno Steen, Kyriacos Markianos, Drucilla Roberts, Kevin G. Broadbelt, Richard G. Goldstein, Laura L. Nelsen, Jacob Cotton, Perri Jacobs, Elizabeth Berg, Jessica Gromer, H Eugene Hoyme, Margaret Jackson, Luke Mack, Bethany Norton, Bradley B. Randall, Mary Ann Sens, Liz Swenson, Deborah Tobacco, Peter Van Eerden, Hendrik Odendaal, Colleen Wright, Lut Geerts, Greetje de Jong, Pawel Schubert, Shabbir Wadee, Johan Dempers, Elsie Burger, Janetta Harbron, Erna Carstens, William Fifer, Michael Myers, Joseph Isler, Yvonne Sininger, J David Nugent, Carmen Condon, Margaret C. Shair, Tracy Thai, and Chuan-Ming Li
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Adult ,Group based ,Health (social science) ,Alcohol Drinking ,medicine.medical_treatment ,Gestational Age ,Toxicology ,Third trimester ,Biochemistry ,White People ,Article ,Developmental psychology ,South Africa ,Young Adult ,03 medical and health sciences ,Behavioral Neuroscience ,Fetus ,0302 clinical medicine ,Pregnancy ,Risk Factors ,Tobacco Smoking ,Humans ,Medicine ,Prospective Studies ,030212 general & internal medicine ,Depression (differential diagnoses) ,Ethanol ,business.industry ,Smoking ,Pregnancy Outcome ,General Medicine ,medicine.disease ,United States ,Mixed ancestry ,Neurology ,Cohort ,Indians, North American ,Smoking cessation ,Female ,Alcohol intake ,Self Report ,business ,030217 neurology & neurosurgery ,Demography - Abstract
Precise identification of drinking and smoking patterns during pregnancy is crucial to better understand the risk to the fetus. The purpose of this manuscript is to describe the methodological approach used to define prenatal drinking and smoking trajectories from a large prospective pregnancy cohort, and to describe maternal characteristics associated with different exposure patterns. In the Safe Passage Study, detailed information regarding quantity, frequency, and timing of exposure was self-reported up to four times during pregnancy and at 1 month post-delivery. Exposure trajectories were developed using data from 11,692 pregnancies (9,912 women) where pregnancy outcome was known. Women were from three diverse populations: white (23%) and American Indian (17%) in the Northern Plains, US, and mixed ancestry (59%) in South Africa (other/not specified [1%]). Group-based trajectory modeling was used to identify 5 unique drinking trajectories (1 none/minimal, 2 quitting groups, 2 continuous groups) and 7 smoking trajectories (1 none/minimal, 2 quitting groups, 4 continuous groups). Women with pregnancies assigned to the low- or high-continuous drinking groups were less likely to have completed high school and were more likely to have enrolled in the study in the third trimester, be of mixed ancestry, or be depressed than those assigned to the none/minimal or quit-drinking groups. Results were similar when comparing continuous smokers to none/minimal and quit-smoking groups. Further, women classified as high- or low-continuous drinkers were more likely to smoke at moderate-, high-, and very high-continuous levels, as compared to women classified as non-drinkers and quitters. This is the first study of this size to utilize group-based trajectory modeling to identify unique prenatal drinking and smoking trajectories. These trajectories will be used in future analyses to determine which specific exposure patterns subsequently manifest as poor peri- and postnatal outcomes.
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- 2017
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15. The dentato-rubro-olivary pathway revisited: New MR imaging observations regarding hypertrophic olivary degeneration
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Julie Lambert, Thomas Decramer, Cindy Mai, Gitte Smets, Johannes van Loon, Maud Tijssen, Wim Vandenberghe, and Philippe Demaerel
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Pathology ,medicine.medical_specialty ,Histology ,Inferior cerebellar peduncle ,medicine.diagnostic_test ,Red nucleus ,business.industry ,Olivary degeneration ,Magnetic resonance imaging ,General Medicine ,Anatomy ,030218 nuclear medicine & medical imaging ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Dentate nucleus ,Medulla oblongata ,medicine ,Inferior olivary nucleus ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Hypertrophic olivary degeneration (HOD) following a lesion of the dentato-rubro-olivary pathway (DROP) is a well-known imaging finding and has extensively been described in the recent literature. We reviewed our patients with HOD as a result of a lesion of the DROP in order to analyze the disruption of the DROP and the resulting HOD in comparison with the literature. We observed unusual imaging findings in four patients. In two patients it concerned new observations related to the timing and imaging appearances of HOD. HOD became only visible 6 years after a lesion in the red nucleus in one patient and a cystic degeneration of the olivary nucleus was seen 3 years after the HOD in a second patient. In two patients we found HOD that could only be explained by the existence of an afferent feedback loop between the dentate nucleus and the inferior olivary nucleus and by the knowledge that these fibers run through the ipsilateral olivary nucleus before ending in the contralateral olivary nucleus. In one of these patients the lesion was located in the inferior cerebellar peduncle. In the other patient the lesion was located on the midline in the medulla oblongata. The imaging findings in these patients reveal new observations in the stages of imaging appearances in HOD and shed light on the forgotten dentato-olivary afferent feedback loop of the DROP. Clin. Anat. 30:543-549, 2017. © 2017 Wiley Periodicals, Inc.
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- 2017
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16. Small airways pathology in Idiopathic Pulmonary Fibrosis: A retrospective cohort study
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Thomas V. Colby, Davide Piloni, Naftali Kaminski, Marc Decramer, Stijn Willems, Craig J. Galbán, James C. Hogg, Geert Verleden, Tillie-Louise Hackett, Laurens J. De Sadeleer, Erik Verbeken, Dragoş M. Vasilescu, Stijn E. Verleden, Naoya Tanabe, Wim A. Wuyts, Joel D. Cooper, Johny Verschakelen, Jeroen Hostens, Feng Xu, Cindy Mai, Bart M. Vanaudenaerde, John E. McDonough, and Dirk Van Raemdonck
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Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,medicine.medical_treatment ,Lung injury ,Multimodal Imaging ,Article ,03 medical and health sciences ,Idiopathic pulmonary fibrosis ,0302 clinical medicine ,Fibrosis ,Multidetector Computed Tomography ,medicine ,Lung transplantation ,Humans ,Lung volumes ,030212 general & internal medicine ,Bronchioles ,Lung ,Retrospective Studies ,business.industry ,Retrospective cohort study ,X-Ray Microtomography ,Middle Aged ,respiratory system ,medicine.disease ,Idiopathic Pulmonary Fibrosis ,respiratory tract diseases ,Transplantation ,medicine.anatomical_structure ,030228 respiratory system ,Female ,Human medicine ,Radiology ,business ,Lung Transplantation - Abstract
Background The observation that patients with idiopathic pulmonary fibrosis (IPF) can have higher than normal expiratory flow rates at low lung volumes led to the conclusion that the airways are spared in IPF. This study aimed to re-examine the hypothesis that airways are spared in IPF using a multiresolution imaging protocol that combines multidetector CT (MDCT), with micro-CT and histology. Methods This was a retrospective cohort study comparing explanted lungs from patients with severe IPF treated by lung transplantation with a cohort of unused donor (control) lungs. The donor control lungs had no known lung disease, comorbidities, or structural lung injury, and were deemed appropriate for transplantation on review of the clinical files. The diagnosis of IPF in the lungs from patients was established by a multidisciplinary consensus committee according to existing guidelines, and was confirmed by video-assisted thoracic surgical biopsy or by pathological examination of the contralateral lung. The control and IPF groups were matched for age, sex, height, and bodyweight. Samples of lung tissue were compared using the multiresolution imaging approach: a cascade of clinical MDCT, micro-CT, and histological imaging. We did two experiments: in experiment 1, all the lungs were randomly sampled; in experiment 2, samples were selected from regions of minimal and established fibrosis. The patients and donors were recruited from the Katholieke Universiteit Leuven (Leuven, Belgium) and the University of Pennsylvania Hospital (Philadelphia, PA, USA). The study took place at the Katholieke Universiteit Leuven, and the University of British Columbia (Vancouver, BC, Canada). Findings Between Oct 5, 2009, and July 22, 2016, explanted lungs from patients with severe IPF (n=11), were compared with a cohort of unused donor (control) lungs (n=10), providing 240 samples of lung tissue for comparison using the multiresolution imaging approach. The MDCT specimen scans show that the number of visible airways located between the ninth generation (control 69 [SD 22] versus patients with IPF 105 [33], p=0.0023) and 14th generation (control 9 [6] versus patients with IPF 49 [28], p
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- 2020
17. MP24-10 THE ROLE OF MPMRI IN STRATIFYING PATIENTS WITH INCREASED RISK OF PROSTATE CANCER
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Wouter Everarts, Raymond Oyen, Maarten Albersen, Filip Claus, Lisa Moris, Liesbeth Dewever, Lauwers Nathalie, Cindy Mai, Vanhoutte Els, Steven Joniau, and Uros Milenkovic
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Oncology ,medicine.medical_specialty ,Prostate cancer ,Increased risk ,business.industry ,Urology ,Internal medicine ,medicine ,medicine.disease ,business ,Multiparametric Magnetic Resonance Imaging - Abstract
INTRODUCTION AND OBJECTIVES:Current evidence strongly supports the use of multiparametric magnetic resonance imaging (mpMRI) pre-biopsy in men with a suspicion of prostate cancer (PCa) based on ele...
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- 2019
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18. Oncological Outcomes of Metastasis-Directed Therapy in Oligorecurrent Prostate Cancer Patients Following Radical Prostatectomy
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Liesbeth De Wever, Karolien Goffin, Maarten Albersen, Arthur Vander Stichele, Hendrik Van Poppel, Cindy Mai, Gaëtan Devos, Charlien Berghen, Gert De Meerleer, Steven Joniau, Wouter Everaerts, and Henri Van Eecke
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Cancer Research ,medicine.medical_specialty ,medicine.medical_treatment ,salvage lymphadenectomy ,030232 urology & nephrology ,Urology ,lcsh:RC254-282 ,Article ,Androgen deprivation therapy ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,Medicine ,Prospective cohort study ,SBRT ,business.industry ,Prostatectomy ,oligorecurrent prostate cancer ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,Radiation therapy ,Oncology ,030220 oncology & carcinogenesis ,Concomitant ,oligometastatic prostate cancer ,Lymphadenectomy ,Metastasectomy ,metastasectomy ,business ,metastasis directed therapy - Abstract
Several retrospective and a few prospective studies have shown that metastasis-directed therapy (MDT) could delay clinical progression and postpone the initiation of systemic treatment in oligorecurrent prostate cancer (PCa) patients. However, these endpoints are strongly influenced by variables such as concomitant use of androgen deprivation therapy (ADT) and follow-up imaging protocols. The aim of this manuscript was to assess palliative ADT- and metastatic castration-resistant prostate cancer (mCRPC)-free survival as long-term oncological outcomes in oligorecurrent PCa treated by MDT. We retrospectively identified consecutive post-prostatectomy oligorecurrent PCa patients treated by MDT (salvage lymphadenectomy, radiotherapy, or metastasectomy) at our tertiary referral center. Patients were eligible for inclusion if they developed recurrence following radical prostatectomy, had &le, 5 metastatic lesions on imaging and had a serum testosterone >, 50 ng/dL or a testosterone suppression therapy-free interval of >, 2 years prior to the first MDT as an assumption of recovered serum testosterone (if no testosterone measurement available). Patients with castration-resistant or synchronous oligometastatic PCa at the time of first MDT were excluded. Repeated MDTs were allowed, as well as a period of concomitant ADT. Kaplan&ndash, Meier analyses were performed to assess palliative ADT-free and mCRPC-free survival. We identified 191 eligible patients who underwent MDT. Median follow-up from first MDT until last follow-up or death was 45 months (IQR 27&ndash, 70, mean 51 months). Estimated median palliative-ADT free survival was 66 months (95% CI 58&ndash, 164) and estimated median mCRPC-free survival was not reached (mean 117 months, 95% CI 103&ndash, 132). In total, 314 MDTs were performed and 25 patients (13%) received &ge, 3 MDTs. This study demonstrated that (repeated) MDT is feasible and holds promise in terms of palliative ADT-free and mCRPC-free survival for patients with oligorecurrent PCa. However, these findings should be confirmed in prospective randomized controlled trials.
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- 2020
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19. Morphometric Analysis of Explant Lungs in Cystic Fibrosis
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François Vermeulen, Marc Decramer, Geert Verleden, Kris De Boeck, Barbara Bosch, Elise Lammertyn, Joel D. Cooper, Johny Verschakelen, Erik Verbeken, Mariette Kemner-van de Corput, Bart M. Vanaudenaerde, Lieven Dupont, John E. McDonough, Marijke Proesmans, Dirk Van Raemdonck, Cindy Mai, Mieke Boon, Stijn E. Verleden, Harm A.W.M. Tiddens, James C. Hogg, Radiology & Nuclear Medicine, and Pediatrics
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Male ,Pathology ,Cystic Fibrosis ,medicine.medical_treatment ,Vital Capacity ,Critical Care and Intensive Care Medicine ,Cystic fibrosis ,0302 clinical medicine ,Forced Expiratory Volume ,Medicine ,Lung volumes ,030212 general & internal medicine ,Respiratory system ,Pneumonectomy ,Lung ,medicine.diagnostic_test ,Organ Size ,Middle Aged ,respiratory system ,Plethysmography ,Residual Volume ,medicine.anatomical_structure ,Airway Remodeling ,Female ,Lung Transplantation ,Adult ,Pulmonary and Respiratory Medicine ,Spirometry ,medicine.medical_specialty ,Bronchi ,Maximal Midexpiratory Flow Rate ,Young Adult ,03 medical and health sciences ,Multidetector Computed Tomography ,Humans ,Lung transplantation ,Bronchioles ,Aged ,business.industry ,Total Lung Capacity ,X-Ray Microtomography ,Airway obstruction ,medicine.disease ,respiratory tract diseases ,Airway Obstruction ,030228 respiratory system ,Case-Control Studies ,Human medicine ,business ,Airway - Abstract
RATIONALE: After repeated cycles of lung infection and inflammation, patients with cystic fibrosis (CF) evolve to respiratory insufficiency. Although histology and imaging have provided descriptive information, a thorough morphometric analysis of end-stage CF lung disease is lacking. OBJECTIVES: To quantify the involvement of small and large airways in end-stage CF. METHODS: Multidetector computed tomography (MDCT) and micro-CT were applied to 11 air-inflated CF explanted lungs and 7 control lungs to measure, count, and describe the airway and parenchymal abnormalities in end-stage CF lungs. Selected abnormalities were further investigated with thin section histology. MEASUREMENTS AND MAIN RESULTS: On MDCT, CF explanted lungs showed an increased median (interquartile range) number (631 [511-710] vs. 344 [277-349]; P = 0.003) and size of visible airways (cumulative airway diameter 217 cm [209-250] vs. 91 cm [80-105]; P < 0.001) compared with controls. Airway obstruction was seen, starting from generation 6 and increasing to 40 to 50% of airways from generation 9 onward. Micro-CT showed that the total number of terminal bronchioles was decreased (2.9/ml [2.6-4.4] vs. 5.3/ml [4.8-5.7]; P < 0.001); 49% were obstructed, and the cross-sectional area of the open terminal bronchioles was reduced (0.093 mm(2) [0.084-0.123] vs. 0.179 mm(2) [0.140-0.196]; P < 0.001). On micro-CT, 41% of the obstructed airways reopened more distally. This remodeling was confirmed on histological analysis. Parenchymal changes were also seen, mostly in a patchy and peribronchiolar distribution. CONCLUSIONS: Extensive changes of dilatation and obstruction in nearly all airway generations were observed in end-stage CF lung disease. ispartof: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE vol:193 issue:5 pages:516-526 ispartof: location:United States status: published
- Published
- 2016
20. The dentato-rubro-olivary pathway revisited: New MR imaging observations regarding hypertrophic olivary degeneration
- Author
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Gitte, Smets, Julie, Lambert, Maud, Tijssen, Cindy, Mai, Thomas, Decramer, Wim, Vandenberghe, Johannes, Van Loon, and Philippe, Demaerel
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Male ,Humans ,Female ,Neurodegenerative Diseases ,Hypertrophy ,Middle Aged ,Olivary Nucleus ,Child ,Magnetic Resonance Imaging - Abstract
Hypertrophic olivary degeneration (HOD) following a lesion of the dentato-rubro-olivary pathway (DROP) is a well-known imaging finding and has extensively been described in the recent literature. We reviewed our patients with HOD as a result of a lesion of the DROP in order to analyze the disruption of the DROP and the resulting HOD in comparison with the literature. We observed unusual imaging findings in four patients. In two patients it concerned new observations related to the timing and imaging appearances of HOD. HOD became only visible 6 years after a lesion in the red nucleus in one patient and a cystic degeneration of the olivary nucleus was seen 3 years after the HOD in a second patient. In two patients we found HOD that could only be explained by the existence of an afferent feedback loop between the dentate nucleus and the inferior olivary nucleus and by the knowledge that these fibers run through the ipsilateral olivary nucleus before ending in the contralateral olivary nucleus. In one of these patients the lesion was located in the inferior cerebellar peduncle. In the other patient the lesion was located on the midline in the medulla oblongata. The imaging findings in these patients reveal new observations in the stages of imaging appearances in HOD and shed light on the forgotten dentato-olivary afferent feedback loop of the DROP. Clin. Anat. 30:543-549, 2017. © 2017 Wiley Periodicals, Inc.
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- 2017
21. Thin-Section CT Features of Idiopathic Pulmonary Fibrosis Correlated with Micro-CT and Histologic Analysis
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Johan Coolen, Johny Verschakelen, Adriana Dubbeldam, Dirk Van Raemdonck, Wim Wuyts, Eric Verbeken, Geert Verleden, Bart M. Vanaudenaerde, Cindy Mai, Walter De Wever, James C. Hogg, Stijn Willems, Stijn E. Verleden, and John E. McDonough
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0301 basic medicine ,Male ,Pathology ,medicine.medical_specialty ,03 medical and health sciences ,Idiopathic pulmonary fibrosis ,0302 clinical medicine ,Fibrosis ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Thin section ct ,In patient ,Stage (cooking) ,Micro ct ,Lung ,Collapse (medical) ,Original Research ,Computer. Automation ,Extramural ,business.industry ,Histological Techniques ,X-Ray Microtomography ,respiratory system ,Middle Aged ,medicine.disease ,Idiopathic Pulmonary Fibrosis ,030104 developmental biology ,030228 respiratory system ,Radiology ,medicine.symptom ,business ,Tomography, X-Ray Computed - Abstract
Purpose To elucidate the underlying lung changes responsible for the computed tomographic (CT) features of idiopathic pulmonary fibrosis (IPF) and to gain insight into the way IPF proceeds through the lungs and progresses over time. Materials and Methods Micro-CT studies of tissue cores obtained from explant lungs were examined and were correlated 1:1 with a CT study obtained immediately before transplantation. Samples for histologic analysis were obtained from selected cores. Results In areas with no or minimal abnormalities on CT images, small areas of increased attenuation located in or near the interlobular septa can be seen on micro-CT studies. In more involved lung areas, the number of opacities increases and opacities enlarge and approach each other along the interlobular septa, causing a fine reticular pattern on CT images. Simultaneously, air-containing structures in and around these opacities arise, corresponding with small cysts on CT images. Honeycombing is caused by a progressive increase in the number and size of these cystic structures and tissue opacities that gradually extend toward the centrilobular region and finally replace the entire lobule. At histologic analysis, the small islands of increased attenuation very likely correspond with fibroblastic foci. Near these fibroblastic foci, an abnormal adjacency of alveolar walls was seen, suggesting alveolar collapse. In later stages, normal lung tissue is replaced by a large amount of young collagen, as seen in patients with advanced fibrosis. Conclusion Fibrosis and cyst formation in patients with IPF seem to start at the periphery of the pulmonary lobule and progressively extend toward the core of this anatomic lung unit. Evidence was found that alveolar collapse might already be present in an early stage when there is only little pulmonary fibrosis. (©) RSNA, 2016. ispartof: Radiology vol:283 issue:1 pages:252-263 ispartof: location:United States status: published
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- 2016
22. Aortic coarctation
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As, Michel, Cindy Mai, Lv, Flore, and Claikens B
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Adult ,lcsh:Medical physics. Medical radiology. Nuclear medicine ,Electrocardiography ,lcsh:R895-920 ,Humans ,Aorta ,stenosis or obstruction ,Aortic Coarctation ,Magnetic Resonance Angiography - Abstract
Background: During elbow surgery on a 20-year-old competition level volleyball player, seriously elevated arterial pressures were found. Systolic pressures were as high as 200 mmHg and diastolic pressures as high as 120 mmHg.
- Published
- 2013
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