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2. Nanosized Delivery Systems for Tissue Regeneration

Author

Cinar, Goksu, Mumcuoglu, Didem, Tekinay, Ayse B., Guler, Mustafa O., Güler, Mustafa O., Tekinay, Ayşe B., and Biomedical Materials and Chemistry

Subjects
0301 basic medicine, Sirna delivery, Protein therapeutics, Computer science, Regeneration (biology), Genetic Alteration, 02 engineering and technology, Computational biology, Gene delivery, 021001 nanoscience & nanotechnology, Systemic targeting, 03 medical and health sciences, Muscle regeneration, 030104 developmental biology, Targeted drug delivery, Cellular internalization, Tissue regeneration, Cytokines, Targeted delivery, 0210 nano-technology, Nanosized delivery, Biomedical engineering
Abstract

Chapter 2 This chapter focuses on advanced delivery of biologics including growth factors (GFs), cytokines, genes, or siRNAs using a variety of nanosized systems for different regeneration applications focusing on bone, cartilage, nervous system, and muscle regeneration strategies. Gene therapy provides permanent genetic alteration, but only transient actions of protein therapeutics can be needed for tissue regeneration applications. The limitations of biologics delivery and alternative strategies for overcoming recent problems are underlined presenting recent examples from the literature. In addition, specific targeting and cellular internalization strategies of biologies delivery for tissue regeneration are discussed for providing future perspectives to the readers in this field. Overall, it is believed that advanced nanosized delivery systems integrated with multicomponent designs will open new opportunities in delivery technologies and strategies for tissue regeneration.

Published
2016

10. Virus-like nanostructures for tuning immune response

Author

Mammadov, Rashad, primary, Cinar, Goksu, additional, Gunduz, Nuray, additional, Goktas, Melis, additional, Kayhan, Handan, additional, Tohumeken, Sehmus, additional, Topal, Ahmet E., additional, Orujalipoor, Ilghar, additional, Delibasi, Tuncay, additional, Dana, Aykutlu, additional, Ide, Semra, additional, Tekinay, Ayse B., additional, and Guler, Mustafa O., additional

Published
2015
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12. Diaqua­Bis(N,N-Diethyl­Nicotinamide-Κn 1)Bis­[4-(Dimethyl­Amino)Benzoato-Κo]Nickel(Ii)

Author

Cinar, Goksu, Orujalipoor, Ilghar, Su, Chun-Jen, Jeng, U-Ser, Ide, Semra, Guler, Mustafa O., and Fizik Mühendisliği

Subjects
Denticity, Chemistry, Hydrogen bond, chemistry.chemical_element, General Chemistry, Crystal structure, Dihedral angle, Condensed Matter Physics, Ring (chemistry), Crystallography, chemistry.chemical_compound, Nickel, Pyridine, General Materials Science, Benzene
Abstract

The centrosymmetric title NiII complex, [Ni(C9H10NO2)2(C10H14N2O)2(H2O)2], contains two dimethyl­amino­benzoate (DMAB), two diethyl­nicotinamide (DENA) ligands and two water mol­ecules, all of them monodentate. The four O atoms in the equatorial plane around the NiII atom form a slightly distorted square-planar arrangement, while the slightly distorted octa­hedral coordination is completed by the two pyridine N atoms of the DENA ligands in axial positions. The NiII atom is displaced by 0.681 (1) A out of the least-squares plane of the carboxyl­ate group. The dihedral angle between the carboxyl­ate group and the adjacent benzene ring is 5.61 (7)°, while the pyridine and benzene rings are oriented at a dihedral angle of 73.20 (4)°. An intra­molecular O—H⋯O hydrogen bond results in the formation of a six-membered ring with a twisted conformation. In the crystal structure, inter­molecular O—H⋯O and C—H⋯O hydrogen bonds link mol­ecules into a three-dimensional network. Two weak C—H⋯π inter­actions are also present.

Published
2009

13. Label-Free Nanometer-Resolution Imaging of Biological Architectures through Surface Enhanced Raman Scattering

Author

Ayas, Sencer, primary, Cinar, Goksu, additional, Ozkan, Alper Devrim, additional, Soran, Zeliha, additional, Ekiz, Oner, additional, Kocaay, Deniz, additional, Tomak, Aysel, additional, Toren, Pelin, additional, Kaya, Yasin, additional, Tunc, Ilknur, additional, Zareie, Hadi, additional, Tekinay, Turgay, additional, Tekinay, Ayse Begum, additional, Guler, Mustafa Ozgur, additional, and Dana, Aykutlu, additional

Published
2013
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16. Local delivery of doxorubicin through supramolecular peptide amphiphile nanofiber gelsElectronic supplementary information (ESI) available. See DOI: 10.1039/c6bm00656f

Author

Cinar, Goksu, Ozdemir, Ayse, Hamsici, Seren, Gunay, Gokhan, Dana, Aykutlu, Tekinay, Ayse B., and Guler, Mustafa O.

Abstract

Peptide amphiphiles (PAs) self-assemble into supramolecular nanofiber gels that provide a suitable environment for encapsulation of both hydrophobic and hydrophilic molecules. The PA gels have significant advantages for controlled delivery applications due to their high capacity to retain water, biocompatibility, and biodegradability. In this study, we demonstrate injectable supramolecular PA nanofiber gels for drug delivery applications. Doxorubicin (Dox), as a widely used chemotherapeutic drug for breast cancer treatment, was encapsulated within the PA gels prepared at different concentrations. Physical and chemical properties of the gels were characterized, and slow release of the Dox molecules through the supramolecular PA nanofiber gels was studied. In addition, the diffusion constants of the drug molecules within the PA nanofiber gels were estimated using fluorescence recovery after the photobleaching (FRAP) method. The PA nanofiber gels did not show any cytotoxicity and the encapsulation strategy enhanced the activity of drug molecules on cellular viability through prolonged release compared to direct administration under in vitroconditions. Moreover, the local in vivoinjection of the Dox encapsulated PA nanofiber gels (Dox/PA) to the tumor site demonstrated the lowest tumor growth rate compared to the direct Dox injection and increased the apoptotic cells within the tumor tissue for local drug release through the PA nanofiber gels under in vivoconditions.

Published
2016
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17. Amyloid Inspired Self-AssembledPeptide Nanofibers.

Author

Cinar, Goksu, Ceylan, Hakan, Urel, Mustafa, Erkal, Turan S., Deniz Tekin, E., Tekinay, Ayse B., Dâna, Aykutlu, and Guler, Mustafa O.

Subjects
*NANOFIBERS, *AMYLOID, *MOLECULAR self-assembly, *PEPTIDES, *NANOELECTROMECHANICAL systems, *RHEOLOGY, *MOLECULAR dynamics
Abstract

Amyloid peptides are important components in many degenerativediseases as well as in maintaining cellular metabolism. Their uniquestable structure provides new insights in developing new materials.Designing bioinspired self-assembling peptides is essential to generatenew forms of hierarchical nanostructures. Here we present oppositelycharged amyloid inspired peptides (AIPs), which rapidly self-assembleinto nanofibers at pH 7 upon mixing in water caused by noncovalentinteractions. Mechanical properties of the gels formed by self-assembledAIP nanofibers were analyzed with oscillatory rheology. AIP gels exhibitedstrong mechanical characteristics superior to gels formed by self-assemblyof previously reported synthetic short peptides. Rheological studiesof gels composed of oppositely charged mixed AIP molecules (AIP-1 2) revealed superior mechanical stability compared to individualpeptide networks (AIP-1 and AIP-2) formed by neutralization of netcharges through pH change. Adhesion and elasticity properties of AIPmixed nanofibers and charge neutralized AIP-1, AIP-2 nanofibers wereanalyzed by high resolution force–distance mapping using atomicforce microscopy (AFM). Nanomechanical characterization of self-assembledAIP-1 2, AIP-1, and AIP-2 nanofibers also confirmed macroscopicrheology results, and mechanical stability of AIP mixed nanofiberswas higher compared to individual AIP-1 and AIP-2 nanofibers self-assembledat acidic and basic pH, respectively. Experimental results were supportedwith molecular dynamics simulations by considering potential noncovalentinteractions between the amino acid residues and possible aggregateforms. In addition, HUVEC cells were cultured on AIP mixed nanofibersat pH 7 and biocompatibility and collagen mimetic scaffold propertiesof the nanofibrous system were observed. Encapsulation of a zwitterionicdye (rhodamine B) within AIP nanofiber network was accomplished atphysiological conditions to demonstrate that this network can be utilizedfor inclusion of soluble factors as a scaffold for cell culture studies. [ABSTRACT FROM AUTHOR]

Published
2012
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