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2. Scaling of transverse nuclear magnetic relaxation due to magnetic nanoparticle aggregation

Author

Brown, K. A., Vassiliou, C. C., Issadore, D., Berezovsky, J., Cima, M. J., and Westervelt, R. M.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Other Condensed Matter
Abstract

The aggregation of superparamagnetic iron oxide (SPIO) nanoparticles decreases the transverse nuclear magnetic resonance (NMR) relaxation time T2 of adjacent water molecules measured by a Carr-Purcell-Meiboom-Gill (CPMG) pulse-echo sequence. This effect is commonly used to measure the concentrations of a variety of small molecules. We perform extensive Monte Carlo simulations of water diffusing around SPIO nanoparticle aggregates to determine the relationship between T2 and details of the aggregate. We find that in the motional averaging regime T2 scales as a power law with the number N of nanoparticles in an aggregate. The specific scaling is dependent on the fractal dimension d of the aggregates. We find T2 N^{-0.44} for aggregates with d=2.2, a value typical of diffusion limited aggregation. We also find that in two-nanoparticle systems, T2 is strongly dependent on the orientation of the two nanoparticles relative to the external magnetic field, which implies that it may be possible to sense the orientation of a two-nanoparticle aggregate. To optimize the sensitivity of SPIO nanoparticle sensors, we propose that it is best to have aggregates with few nanoparticles, close together, measured with long pulse-echo times., Comment: 20 pages, 3 figures, submitted to Journal of Magnetism and Magnetic Materials

Published
2010
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4. A Space In-Between

Author

khademi, cima m

Abstract

A Space In-Between, is a series of works that explores a balance between two radically different cultures that the artist identifies with through visual language. The experience of immigration as an Iranian body in a Western context is investigated through works in sculpture, photography and video. By using the language of materials, the artist explores the diasporic space regarding class, gender, and ethnicity. The practice of creating Iranian designs with American products such as a muqarnas from cigarette cartons from her family’s convenient store in Bessemer, Alabama, or creating a chadorfrom Mossy Oak camouflage, acts as an effort to visualize and harmonize her experience living between Iranian and American culture.

Published
2022
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5. Erratum: Gut epithelial impairment, microbial translocation and immune system activation in inflammatory bowel disease-Associated spondyloarthritis (Rheumatology (2021) 60 (92–102) DOI: 10.1093/rheumatology/keaa164)

Author

Luchetti M. M., Ciccia F., Avellini C., Benfaremo D., Rizzo A., Spadoni T., Svegliati S., Marzioni D., Santinelli A., Costantini A., Viola N., Berretta A., Ciferri M., Mattioli Belmonte Cima M., Mosca P., Benedetti A., Gabrielli A., Luchetti, M. M., Ciccia, F., Avellini, C., Benfaremo, D., Rizzo, A., Spadoni, T., Svegliati, S., Marzioni, D., Santinelli, A., Costantini, A., Viola, N., Berretta, A., Ciferri, M., Mattioli Belmonte Cima, M., Mosca, P., Benedetti, A., and Gabrielli, A.

Abstract

In the above article the wrong image was used for the hystochemical analysis of Claudin-1 in the Spa/IBD panel in Figure 1. This has now been corrected online.

Published
2021

7. Morele ontwikkeling en delinquentie

Author

Schalkwijk, F., Cima, M., van Langen, M., Spruit, A., van Vugt, E., Hendriks, J., Stams, G.J., Asscher, J., and Forensic Child and Youth Care (RICDE, FMG)

Published
2021

27. Structural analysis on lightweigth excavator arms

Author

Solazzi, L., Ceresoli, F., and Cima, M.

Subjects
Ligthweigth, Buckling phenomena, Structural analyses, Weigth optimization, Movement law, Design with alluminium alloy, Excavator, Load condition
Published
2019

29. The role of the intensive care unit in real-time surveillance of emerging pandemics: the Italian GiViTI experience

Author

Bertolini, G, Nattino, G, Langer, M, Tavola, M, Crespi, D, Mondini, M, Rossi, C, Previtali, C, Marshall, J, Poole, D, Abascià, A, Acquarolo, A, Adorni, A, Agnelli, V, Agostini, F, Alampi, D, Alberti, A, Alborghetti, A, Alleva, S, Ambrosoni, S, Antonini, B, Arditi, E, Avalli, L, Babini, M, Bagalini, G, Balata, A, Balicco, B, Barbagallo, M, Bartoli, T, Bassi, G, Becarelli, S, Beck, E, Bellin, M, Bellonzi, A, Bellorini, M, Benanti, C, Bensi, M, Bernasconi, Mo, Berruto, F, Bertolini, R, Besozzi, A, Biamino, C, Bianchi, T, Bianchin, A, Boccalatte, D, Bocchi, A, Bonaccorso, G, Bonazzi, M, Balsamo, C, Bonicalzi, V, Boniotti, C, Bonizzoli, M, Bottazzi, A, Breschi, C, Brizio, E, Brunetti, B, Brunori, E, Bubbico, G, Buscaglia, G, Calicchio, G, Calligaro, P, Calva, S, Candido, M, Capitanio, G, Caroleo, S, Casagli, S, Casalini, P, Castiglione, G, Cerana, M, Chiani, C, Chierego, G, Ciani, A, Ciceri, R, Cigada, Mg, Cima, M, Cingolani, E, Cinque, E, Coletta, Rp, Colombo, L, Colombo, R, Converso, M, Corrado, A, Cortis, G, Costagli, V, Crema, L, Crestan, E, Da, D, Cero, Pd, Ferro, Md, De Blasi RA, De Blasio, E, De Cristofaro MG, De Luca, A, Di Pasquale, D, Doroni, L, Fabi, Mc, Facondini, F, Fagoni, Nazzareno, Falzetti, G, Faraldi, L, Fiore, G, Fiume, C, Galeotti, E, Galleschi, N, Gallo, M, Gamberini, E, Garelli, A, Giacomello, S, Gianni, M, Giudici, R, Giuntini, R, Gnesin, P, Gorietti, A, Grassitelli, S, Greco, M, Irpino, A, Guadagna, A, Guadagnucci, A, Guagliardi, C, Laici, C, Lain, G, Lanza, G, Lefons, U, Leggieri, C, Lembo, R, Librenti, M, Liverani, C, Longobardo, A, Madeira, Sm, Madonna, R, Magatti, Mf, Mamprin, F, Mannolini, G, Marafon, S, Marchesi, G, Marifoglou, D, Martinelli, P, Martinelli, S, Escobar, Rm, Mastroianni, A, Mastropierro, R, Mediani, Ts, Messina, M, Milan, B, Molesi, A, Alberto, Cm, Mongelli, P, Morigi, A, Mosti, G, Muttini, S, Nardini, M, Nascimben, E, Natalini, G, Negri, G, Negro, G, Neri, M, Netto, R, Nonini, S, Odetto, L, Olivieri, C, Candida, Mo, Osti, D, Palmer, M, Parnigotto, A, Parrini, V, Pasculli, M, Pasetti, G, Passafiume, M, Pastorini, S, Patrignani, L, Pedeferri, M, Pegoraro, M, Pelati, E, Pelosi, G, Pera, L, Perino, P, Pero, A, Perzolla, D, Peta, M, Pinna, C, Pizzali, M, Postiglione, M, Potalivo, A, Raffaeli, M, Randellini, R, Rech, A, Renda, B, Ricciardi, G, Rizzi, S, Romagnoli, S, Rossi, G, Rossi, M, Rutta, C, Sagliaschi, U, Salcuni, R, Salvi, G, Scalera, M, Scarrone, S, Schiavuzzi, M, Aurelio, Ps, Selvaggi, P, Sicignano, A, Sorbara, C, Spagarino, E, Sparicio, D, Spinazzola, Ar, Sucre, Mj, Terzitta, M, Tetamo, R, Tibaldi, G, Todesco, L, Tomaselli, P, Torta, M, Turriziani, I, Ughi, L, Vaccari, C, Vaj, M, Vanzino, R, Vardanega, A, Vecchiarelli, P, Vedovati, S, Zanni, V, Zappa, S, Zardin, M, Zaro, G, Zuccaro, F, Barattini, M, Chieregato, A, Fumagalli, R, Livigni, S, Mengoli, F, Nardi, G, Palma, D, Portolani, L, Radrizzani, D, Terzitta, M., Bertolini, G, Nattino, G, Langer, M, Tavola, M, Crespi, D, Mondini, M, Rossi, C, Previtali, C, Marshall, J, Poole, D, Abascia, A, Acquarolo, A, Adorni, A, Agnelli, V, Agostini, F, Alampi, D, Alberti, A, Alborghetti, A, Alleva, S, Ambrosoni, S, Antonini, B, Arditi, E, Avalli, L, Babini, M, Bagalini, G, Balata, A, Balicco, B, Barbagallo, M, Bartoli, T, Bassi, G, Becarelli, S, Beck, E, Bellin, M, Bellonzi, A, Bellorini, M, Benanti, C, Bensi, M, Bernasconi, M, Berruto, F, Besozzi, A, Biamino, C, Bianchi, T, Bianchin, A, Boccalatte, D, Bocchi, A, Bonaccorso, G, Bonazzi, M, Balsamo, C, Bonicalzi, V, Boniotti, C, Bonizzoli, M, Bottazzi, A, Breschi, C, Brizio, E, Brunetti, B, Brunori, E, Bubbico, G, Buscaglia, G, Calicchio, G, Calligaro, P, Calva, S, Candido, M, Capitanio, G, Caroleo, S, Casagli, S, Casalini, P, Castiglione, G, Cerana, M, Chiani, C, Chierego, G, Ciani, A, Ciceri, R, Cigada, M, Cima, M, Cingolani, E, Cinque, E, Coletta, R, Colombo, L, Colombo, R, Converso, M, Corrado, A, Cortis, G, Costagli, V, Crema, L, Crestan, E, Da, D, Cero, P, Ferro, M, De Blasi, R, De Blasio, E, De Cristofaro, M, De Luca, A, Di Pasquale, D, Doroni, L, Fabi, M, Facondini, F, Fagoni, N, Falzetti, G, Faraldi, L, Fiore, G, Fiume, C, Galeotti, E, Galleschi, N, Gallo, M, Gamberini, E, Garelli, A, Giacomello, S, Gianni, M, Giudici, R, Giuntini, R, Gnesin, P, Gorietti, A, Grassitelli, S, Greco, M, Irpino, A, Guadagna, A, Guadagnucci, A, Guagliardi, C, Laici, C, Lain, G, Lanza, G, Lefons, U, Leggieri, C, Lembo, R, Librenti, M, Liverani, C, Longobardo, A, Madeira, S, Madonna, R, Magatti, M, Mamprin, F, Mannolini, G, Marafon, S, Marchesi, G, Marifoglou, D, Martinelli, P, Martinelli, S, Escobar, R, Mastroianni, A, Mastropierro, R, Mediani, T, Messina, M, Milan, B, Molesi, A, Alberto, C, Mongelli, P, Morigi, A, Mosti, G, Muttini, S, Nardini, M, Nascimben, E, Natalini, G, Negri, G, Negro, G, Neri, M, Netto, R, Nonini, S, Odetto, L, Olivieri, C, Candida, M, Osti, D, Palmer, M, Parnigotto, A, Parrini, V, Pasculli, M, Pasetti, G, Passafiume, M, Pastorini, S, Patrignani, L, Pedeferri, M, Pegoraro, M, Pelati, E, Pelosi, G, Pera, L, Perino, P, Pero, A, Perzolla, D, Peta, M, Pinna, C, Pizzali, M, Postiglione, M, Potalivo, A, Raffaeli, M, Randellini, R, Rech, A, Renda, B, Ricciardi, G, Rizzi, S, Romagnoli, S, Rossi, G, Rossi, M, Rutta, C, Sagliaschi, U, Salcuni, R, Salvi, G, Scalera, M, Scarrone, S, Schiavuzzi, M, Aurelio, P, Selvaggi, P, Sicignano, A, Sorbara, C, Spagarino, E, Sparicio, D, Spinazzola, A, Sucre, M, Terzitta, M, Tetamo, R, Tibaldi, G, Todesco, L, Tomaselli, P, Torta, M, Turriziani, I, Ughi, L, Vaccari, C, Vaj, M, Vanzino, R, Vardanega, A, Vecchiarelli, P, Vedovati, S, Zanni, V, Zappa, S, Zardin, M, Zaro, G, Zuccaro, F, Barattini, M, Chieregato, A, Fumagalli, R, Livigni, S, Mengoli, F, Nardi, G, Palma, D, Portolani, L, and Radrizzani, D

Subjects
medicine.medical_specialty, Epidemiology, surveillance system, law.invention, 03 medical and health sciences, Influenza A Virus, H1N1 Subtype, 0302 clinical medicine, Public health surveillance, law, Infectious disease epidemiology, influenza, pandemic, Humans, Influenza, Human, Intensive Care Units, Italy, Public Health Surveillance, Pandemics, Pandemic, medicine, human, 030212 general & internal medicine, medicine (all), Intensive care medicine, business.industry, Public health, Outbreak, 030208 emergency & critical care medicine, Monitoring system, medicine.disease, Intensive care unit, infectious disease epidemiology, humans, influenza a virus, h1n1 subtype, intensive care units, italy, public health surveillance, pandemics, infectious diseases, epidemiology, Infectious Diseases, Human mortality from H5N1, Medical emergency, business
Abstract

SUMMARYThe prompt availability of reliable epidemiological information on emerging pandemics is crucial for public health policy-makers. Early in 2013, a possible new H1N1 epidemic notified by an intensive care unit (ICU) to GiViTI, the Italian ICU network, prompted the re-activation of the real-time monitoring system developed during the 2009–2010 pandemic. Based on data from 216 ICUs, we were able to detect and monitor an outbreak of severe H1N1 infection, and to compare the situation with previous years. The timely and correct assessment of the severity of an epidemic can be obtained by investigating ICU admissions, especially when historical comparisons can be made.

Published
2015

33. Three dimensional printing: rapid tooling and prototypes directly from a CAD model

Author

Sachs, E., Cima, M., Williams, P., Brancazio, D., and Cornie, J.

Subjects
Computer-aided design -- Research, Machine-tools -- Design and construction, Engineering and manufacturing industries, Science and technology
Abstract

Three Dimensional Printing is a process for the manufacture of tooling and functional prototype parts directly from computer models. Three Dimensional Printing functions by the deposition of powdered material in layers and the selective binding of the powder by 'ink-jet' printing of a binder material. Following the sequential application of layers, the unbound powder is removed, resulting in a complex three-dimensional part. The process may be applied to the production of metal, ceramic, and metal-ceramic composite parts. An experiment employing continuous-jet ink-jet printing technology has produced a three-dimensional ceramic part constructed of 50 layers, each 0.005 in. thick. The powder is alumina and the binder is colloidal silica. The minimum feature size is 0.017 in., and features intended to be 0.5000 in. apart average 0.4997 in. apart in the green state and 0.5012 in. apart in the cured state, with standard deviations of 0.0005 in. and 0.0018 in., respectively. Future research will be directed toward the direct fabrication of cores and shells for metal casting, and toward the fabrication of porous ceramic preforms for metal-ceramic composite parts.

Published
1992

34. Genetic polymorphisms in CYP1A1, GSTM1, GSTP1 and GSTT1 metabolic genes and risk of lung cancer in Asturias

Author

López-Cima M, Álvarez-Avellón Sara M, Pascual Teresa, Fernández-Somoano Ana, and Tardón Adonina

Subjects
Lung cancer, Polymorphisms, Metabolic genes, CYP1A1, GSTM1, GSTP1, GSTT1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Metabolic genes have been associated with the function of metabolizing and detoxifying environmental carcinogens. Polymorphisms present in these genes could lead to changes in their metabolizing and detoxifying ability and thus may contribute to individual susceptibility to different types of cancer. We investigated if the individual and/or combined modifying effects of the CYP1A1 MspI T6235C, GSTM1 present/null, GSTT1 present/null and GSTP1 Ile105Val polymorphisms are related to the risk of developing lung cancer in relation to tobacco consumption and occupation in Asturias, Northern Spain. Methods A hospital-based case–control study (CAPUA Study) was designed including 789 lung cancer patients and 789 control subjects matched in ethnicity, age, sex, and hospital. Genotypes were determined by PCR or PCR-RFLP. Individual and combination effects were analysed using an unconditional logistic regression adjusting for age, pack-years, family history of any cancer and occupation. Results No statistically significant main effects were observed for the carcinogen metabolism genes in relation to lung cancer risk. In addition, the analysis did not reveal any significant gene-gene, gene-tobacco smoking or gene-occupational exposure interactions relative to lung cancer susceptibility. Lastly, no significant gene-gene combination effects were observed. Conclusions These results suggest that genetic polymorphisms in the CYP1A1, GSTM1, GSTT1 and GSTP1 metabolic genes were not significantly associated with lung cancer risk in the current study. The results of the analysis of gene-gene interactions of CYP1A1 MspI T6235C, GSTM1 present/null, GSTT1 present/null and GSTP1 Ile105Val polymorphisms in lung cancer risk indicate that these genes do not interact in lung cancer development.

Published
2012
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35. Genetic polymorphisms in MMP 2, 9 and 3 genes modify lung cancer risk and survival

Author

González-Arriaga Patricia, Pascual Teresa, García-Alvarez Arturo, Fernández-Somoano Ana, López-Cima M Felicitas, and Tardón Adonina

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Matrix metalloproteases (MMPs) are proteolytic enzymes that contribute to all stages of tumour progression, including the later stages of invasion and metastasis. Genetic variants in the MMP genes may influence the biological function of these enzymes and change their role in carcinogenesis and progression. We have investigated the association between the -735 C/T, the -1171 5A/6A, and the -1562 C/T polymorphisms in the MMP2, MMP3 and MMP9 genes, respectively, and the risk and survival of lung cancer. Methods The case-control study includes 879 lung cancer patients and 803 controls from a Caucasian population in Spain (CAPUA study). Genotypes were determined by PCR-RFLP. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression. The Kaplan-Meier method, long-rank test and Cox's were used for the survival analysis. Results The MMP9 -1562 T/T genotype was associated with a statistically significant decreased risk of developing lung cancer (OR = 0.23; 95% CI: 0.06-0.85), whereas no association was found for the MMP2 -735 C/T and MMP3 -1171 5A/6A polymorphisms. The MMP2 -735 T/T genotype was statistically significantly associated with a decreased survival in non-small cell lung cancer (NSCLC) patients, identified as an independent prognosis factor of survival (hazard ratio (HR) = 1.79; 95% CI: 1.00-3.20). In contrast, no association was found between the MMP3 -1171 5A/6A and the MMP9 -1562 C/T polymorphisms and survival. Conclusions These findings support the hypothesis that the MMP9 -1562 C/T polymorphism is associated with a protective effect against the development of lung cancer and suggest that the MMP2 -735 C/T polymorphism modify the length of survival in NSCLC patients.

Published
2012
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36. Long‐Term Safety of Rituximab in Patients With Rheumatoid Arthritis: Results of a Five‐Year Observational Study

Author

Winthrop, Kevin L., primary, Saag, Kenneth, additional, Cascino, Matthew D., additional, Pei, Jinglan, additional, John, Ani, additional, Jahreis, Angelika, additional, Haselkorn, Tmirah, additional, Furst, Daniel E., additional, Abdulky, M., additional, Abeles, M., additional, Adelglass, H., additional, Ahmed, A., additional, Alloway, J., additional, Alper, J., additional, Anand, A., additional, Anderson, J., additional, Arora, M., additional, Askari, A., additional, Baca, S., additional, Bacha, D., additional, Bagheri, S., additional, Ballou, S., additional, Bennett, R., additional, Bidula, L., additional, Blumstein, H., additional, Bognar, M., additional, Bohan, A., additional, Boniske, C., additional, Borofsky, M., additional, Box, E., additional, Braun, A., additional, Brennan, T., additional, Brent, L., additional, Cabalar, I., additional, Carteron, N., additional, Chaudhary, K., additional, Chauhan, A., additional, Cima, M., additional, Cochinwala, A., additional, Cohen, H., additional, Colburn, K., additional, Conaway, D., additional, Danning, C., additional, Dao, K., additional, Dean, J., additional, Diab, I., additional, Diegel, R., additional, Ditzian‐Kadanoff, R., additional, Dowd, J., additional, Dugowson, C., additional, Eggebeen, A., additional, El‐Kadi, H., additional, Feinberg, H., additional, Feinman, M., additional, Feinstein, J., additional, Fischer, A., additional, Foad, B., additional, Fondal, M., additional, Fraser, S., additional, Fraser, A., additional, Freeman, P., additional, Garber, M., additional, Goldstein, A., additional, Golombek, S., additional, Greenstein, N., additional, Greenwald, M., additional, Hakim, C., additional, Halla, J., additional, Hallegua, D., additional, Han, K., additional, Harris, B., additional, Hauptman, H., additional, Hirsh, J., additional, Hoffman, M., additional, Huntwork, J., additional, Husni, M., additional, Hyer, F., additional, Hymowitz, R., additional, Jones, R., additional, Kanagasegar, S., additional, Kappes, J., additional, Keating, R., additional, Kelly, G., additional, Kim, J., additional, King, C., additional, Klashman, D., additional, Knee, C., additional, Kolba, K., additional, Krick, G., additional, Krug, H., additional, Kumar, U., additional, Lakhanpal, S., additional, Lang, T., additional, Lauter, S., additional, Lawrence Ford, T., additional, Lee, W., additional, Lee, Y., additional, Leisen, J., additional, Levine, J., additional, Lidman, R., additional, Lipstate, J., additional, Malinak, J., additional, Marcus, R., additional, Martin, D., additional, Mehta, C., additional, Melton, G., additional, Metyas, S., additional, Miller, K., additional, Moidel, R., additional, Moore, C., additional, Mossell, J., additional, Munoz, G., additional, Murphy, F., additional, Nami, A., additional, Nascimento, J., additional, Neal, N., additional, Neiman, R., additional, Neuwelt, C., additional, Nguyen, P., additional, Niemer, M., additional, Oelke, K., additional, Oza, M., additional, Pachaidee, S., additional, Patel, S., additional, Pegram, S., additional, Penmetcha, M., additional, Perkins, J., additional, Perl, A., additional, Peterson, L., additional, Pittsley, R., additional, Portnoff, K., additional, Rahmani, D., additional, Raja, N., additional, Ratnoff, W., additional, Rezaian, M., additional, Rhea, C., additional, Rice, D., additional, Ridley, D., additional, Rivadeneira, A., additional, Rizzo, W., additional, Roane, G., additional, Rocca, P., additional, Rosen, M., additional, Saikali, W., additional, Saitta, M., additional, Sankoorikal, A., additional, Saway, P., additional, Schneider, P., additional, Schwartzman, S., additional, Scoville, C., additional, Shergy, W., additional, Shiel, W, additional, Shurmur, R., additional, Sikes, D., additional, Singhal, A., additional, Snyder, A., additional, Songcharoen, S., additional, Sosenko, M., additional, Soto Raices, O., additional, Stahl, N., additional, Stark, K., additional, Strachan, M., additional, Stupi, A., additional, Sullivan, N., additional, Sylvester, R., additional, Tabechian, D., additional, Tagoe, C., additional, Taylor, P., additional, Thakker, S., additional, Thakor, M., additional, Thakur, N., additional, Tidmore, W., additional, Toth, M., additional, Trostle, D., additional, Udell, J., additional, Van de Stouwe, M., additional, Venuturupalli, R., additional, Weiss, D., additional, Weselman, K., additional, Winn, D., additional, Yung, C., additional, Zable, E., additional, and Zamiri, B., additional

Published
2019
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38. Polymorphism +17 C/G in Matrix Metalloprotease MMP8 decreases lung cancer risk

Author

Tardón Adonina, Puente Xose S, Pascual Teresa, Marrón Manuel G, Fernández-Somoano Ana, López-Cima M Felicitas, and González-Arriaga Patricia

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Matrix metalloproteases (MMPs) constitute a family of enzymes capable of degrading different components of the extracellular matrix and are implicated in the invasion of tumor cells through the basement membrane. Polymorphisms in MMP genes may result in changes in the expression of MMPs being associated with the development and progression of cancer. We have investigated the association between three polymorphisms (-1607 1G/2G, +17 C/G and -77 A/G) in the human collagenases MMP1, MMP8 and MMP13 and the risk of development or progression of lung cancer. Methods A hospital-based case-control study was designed including 501 lung cancer patients and 510 controls matched. Genotypes were determined by PCR-RFLP. Results were analyzed using unconditional logistic regression, Cox's proportional hazard regression, and the Kaplan-Meier method. Results The MMP1 and MMP13 promoter polymorphisms were not associated with lung cancer risk, while the C/G polymorphism in MMP8 was associated with a statistically significant decreased risk of developing lung cancer (ORadj = 0.65; 95%CI = 0.45–0.93). The Kaplan-Meier analysis showed that the polymorphisms in MMP1, MMP8 and MMP13 not seem to modify the overall survival. Multivariate analysis revealed that MMP1, MMP8 and MMP13 polymorphisms are not independent prognostic factors for overall survival. Conclusion This study suggests that the polymorphism in MMP8 is associated with a decreased lung cancer risk, which can be used as a prognostic marker in lung cancer.

Published
2008
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39. Polymorphisms in XPC, XPD, XRCC1, and XRCC3 DNA repair genes and lung cancer risk in a population of Northern Spain

Author

Tardón Adonina, Puente Xose S, Marrón Manuel G, Pascual Teresa, García-Castro Laura, González-Arriaga Patricia, and Felicitas López-Cima M

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Polymorphisms in DNA repair genes have been associated to repair DNA lesions, and might contribute to the individual susceptibility to develop different types of cancer. Nucleotide excision repair (NER), base excision repair (BER), and double-strand break repair (DSBR) are the main DNA repair pathways. We investigated the relationship between polymorphisms in two NER genes, XPC (poly (AT) insertion/deletion: PAT-/+) and XPD (Asp312Asn and Lys751Gln), the BER gene XRCC1 (Arg399Gln), and the DSBR gene XRCC3 (Thr241Met) and the risk of developing lung cancer. Methods A hospital-based case-control study was designed with 516 lung cancer patients and 533 control subjects, matched on ethnicity, age, and gender. Genotypes were determined by PCR-RFLP and the results were analysed using multivariate unconditional logistic regression, adjusting for age, gender and pack-years. Results Borderline association was found for XPC and XPD NER genes polymorphisms, while no association was observed for polymorphisms in BER and DSBR genes. XPC PAT+/+ genotype was associated with no statistically significant increased risk among ever smokers (OR = 1.40; 95%CI = 0.94–2.08), squamous cell carcinoma (OR = 1.44; 95%CI = 0.85–2.44), and adenocarcinoma (OR = 1.72; 95%CI = 0.97–3.04). XPD variant genotypes (312Asn/Asn and 751Gln/Gln) presented a not statistically significant risk of developing lung cancer (OR = 1.52; 95%CI = 0.91–2.51; OR = 1.38; 95%CI = 0.85–2.25, respectively), especially among ever smokers (OR = 1.58; 95%CI = 0.96–2.60), heavy smokers (OR = 2.07; 95%CI = 0.74–5.75), and adenocarcinoma (OR = 1.88; 95%CI = 0.97–3.63). On the other hand, individuals homozygous for the XRCC1 399Gln allele presented no risk of developing lung cancer (OR = 0.87; 95%CI = 0.57–1.31) except for individuals carriers of 399Gln/Gln genotype and without family history of cancer (OR = 0.57; 95%CI = 0.33–0.98) and no association was found between XRCC3 Thr241Met polymorphism and lung cancer risk (OR = 0.92; 95%CI = 0.56–1.50), except for the 241Met/Met genotype and squamous cell carcinoma risk (OR = 0.47; 95%CI = 0.23–1.00). Conclusion In conclusion, we analysed the association between XPC, XPD, XRCC1, and XRCC3 polymorphisms and the individual susceptibility to develop lung cancer in the Spanish population, specifically with a highly tobacco exposed population. We attempt to contribute to the discovery of which biomarkers of DNA repair capacity are useful for screening this high-risk population for primary preventing and early detection of lung cancer.

Published
2007
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42. Contemporary approaches to psychopathy

Author

Brazil, I.A., Cima, M.J., Cima, M., and Cima, M.

Subjects
Neuro- en revalidatiepsychologie, Neuropsychology and rehabilitation psychology, Plasticity and Memory [DI-BCB_DCC_Theme 3], Developmental Psychopathology
Abstract

Item does not contain fulltext

Published
2016

46. The prognostic importance of chronic end-stage diseases in geriatric patients admitted to 163 Italian ICUs

Author

Poole, D., Finazzi, S., Nattino, G., Radrizzani, D., Gristina, G., Malacarne, P., Livigni, S., Bertolini, G., Sorgato, C., Mannoni, R., Agnelli, V., Chiani, C., Lanza, G., Venturini, E., Gianni, M., Olivieri, M. C., Guerriero, B., Della Mora, E., Palmer, M., Blasetti, A., Coletta, R., Covani Frigieri, F., Guarducci, M. D., Caracciolo, A., Lain, G., Bernard, M., DE Blasio, E., Zanni, V., Marchesi, G., Madeira, S. M., Spagarino, E., Potalivo, A., Mengoli, F., Parrini, V., Sagliaschi, U., Prandini, A., Rosano, A., Natalini, G., Piccioni, G., Schiavuzzi, M., Bronzini, N., Piva, S., Besozzi, A., Napoleone, A., Patrignani, L., Pisu, M., Mancosu, S., Chiarello, M., Pastorini, S., Bassi, G., Negro, G., Orsini, I., Marifoglou, D., Pota, V., Pegoraro, M., Sucre, M. J., DI Masi, P., Castiglione, G., Morello, G., Garofalo, G., Caroleo, S., Visconti, M. G., Gamberini, E., Mastroianni, A., Liccardi, M. M., Anelati, D., Martinelli, S., Bonato, A., Adorni, A., Colombo, D., Dal Cero, P., Crema, L., Petrucci, N., Beck, E., Alleva, S., Giuntini, R., DA Re, D., Casalini, P., Fabi, M. C., Galeotti, E., Bagalini, G., Bellonzi, A., Zoppellari, R., Lamborghini, S., Pera, L., Doni, L., Bonizzoli, M., Librenti, M., Barattini, M., Mangani, V., Terzitta, M., Guagliardi, C., Bruzzone, C., Arditi, E., Cerana, M., Tavola, M., Falini, S., Vespignani, M. G., Salvi, G., Ramello, P. L., Molesi, A., Ceradelli, M., Buonanno, R., Righini, E., DI Cocco, A., DI Martino, R., Cinque, E., Bonfiglio, M., Ciceri, R., Colombo, L., Nardini, M., Rossi, G., Boccalatte-Rosa, D. L., Babini, M., Zompanti, V., Negri, G., Antonini, B., Baratta, A., Zuccaro, F., Rossi, M., Pedeferri, M., Bellin, M., Sicignano, A., Pezzi, A., Leggieri, C., Fontana, G., Faraldi, L., Cigada, M. G., Magenta, P., Colombo, R., Colombo, S., Gonzi, S., Pizzali, M., Girardis, M., Piccinini, P., Bignone, P., Padovan, L., Bianchin, A., Caria, F. C., Randellini, R., Roticiani, V., Grassi, M., Belluomo Anello, C., Decristofaro, M., Postiglione, M., Giacomello, S., Olivieri, C., Vaccari, C., Dal Ferro, M., Messina, M., Belgiorno, N., Odetto, L., Pasetti, G. S., Balicco, B., Pizzaballa, M. L., Muraro, L., Pignataro, A., Guadagna, A., Fabbri, P. G., Tetamo, R., Bottazzi, A., Mediani, T. S., Gorietti, A., Breschi, C., Ciani, A., Segalini, P., Codeluppi, V., Berruto, F., Pastorelli, M., Comite, C., Pelati, E., Bertolini, R., Lefons, U., DI Pasquale, D. A., Mannolini, G., Vlassich, F., Becarelli, S., Garelli, A., Salsi, P., Rossi, S., Facondini, F., Alampi, D., Cingolani, E., Molino, F. M., Nardi, G., Casula, M., DE Blasi, R. A., Vulcano, G. A., Azzolini, M., Bernasconi, M. O., Bellato, V., Calicchio, G., Righetti, F., Turati, M., Dei Poli, M., Zaro, G., Brizio, E., Coaloa, M., Falzetti, G., Mamprin, F., Liverani, C. M., Clementi, S., Bonucci, P., Varesio, V., Pannacci, R., Fiore, G., Gallo, M., Torta, M., Selvaggi, P., Bert, P. P., Segala, V., Pettazzi, G., Bensi, M., Bocchi, A., Cima, M., Morbelli, M., Peta, M., DI Stella, R., Maggiolo, C., Lembo, R., Pero, A., Marafon, S., Carnevale, L., Vanzino, R., Vecchiarelli, P., and Marino, G.

Subjects
Male, medicine.medical_specialty, Cirrhosis, Disease, Severity of Illness Index, law.invention, 03 medical and health sciences, 0302 clinical medicine, Patient Admission, Postoperative Complications, law, Internal medicine, 80 and over, aged, critical care, prognosis, Medicine, Dementia, Humans, Hospital Mortality, Elective surgery, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Critical care, Prognosis, Female, Intensive Care Units, Italy, Chronic Disease, 030208 emergency & critical care medicine, Odds ratio, medicine.disease, Comorbidity, Intensive care unit, Anesthesiology and Pain Medicine, 030228 respiratory system, Cohort, business
Abstract

BACKGROUND The number of elderly patients undergoing major surgical interventions and then needing admission to intensive care unit (ICU) grows steadily. We investigated this issue in a cohort of 232,278 patients admitted in five years (2011-2015) to 163 Italian general ICUs. METHODS Surgical patients older than 75 registered in the GiViTI MargheritaPROSAFE project were analyzed. The impact on hospital mortality of important chronic conditions (severe COPD, NYHA class IV, dementia, end-stage renal disease, cirrhosis with portal hypertension) was investigated with two prognostic models developed yearly on patients staying in the ICU less or more than 24 hours. RESULTS 44,551 elderly patients (19.2%) underwent emergency (47.3%) or elective surgery (52.7%). At least one severe comorbidity was present in 14.6% of them, yielding a higher hospital mortality (32.4%, vs. 21.1% without severe comorbidity). In the models for patients staying in the ICU 24 hours or more, cirrhosis, NYHA class IV, and severe COPD were constant independent predictors of death (adjusted odds ratios [ORs] range 1.67-1.97, 1.54-1.91, and 1.34-1.50, respectively), while dementia was statistically significant in four out of five models (adjusted ORs 1.23-1.28). End-stage renal disease, instead, never resulted to be an independent prognostic factor. For patients staying in the ICU less than 24 hours, chronic comorbidities were only occasionally independent predictors of death. CONCLUSIONS Our study confirms that elderly surgical patients represent a relevant part of all ICUs admissions. About one of seven bear at least one severe chronic comorbidity, that, excluding end-stage renal disease, are all strong independent predictors of hospital death.

Published
2017

47. Aggression

Author

Tonnaer, F., Cima, M., Arntz, A., Klinische Psychologie (Psychologie, FMG), and FMG

Abstract

Human aggression, violence and deviant behaviour are not only a great cost for society − up to $40.2 billion yearly only for England and Wales and 3.3% of the gross domestic product in America (Waters et al., 2004) − but have also great consequences for general health as they are among the world’s foremost causes of death (Krug, Dahlberg, Mercy, Zwi, & Lozano, 2002). Moreover, violence is often stated as a preventable public health problem (Gilligan, 1997). A search for literature on human aggression shows that different terms, such as aggression and violence, are frequently used interchangeably (Perry, 2001), although they actually differ in meaning. Therefore, the current chapter starts by defining the different concepts. Furthermore, the current chapter will further outline several subtypes of aggression and explain the concept of impulsivity in the context of aggression and forensic risk assessment. Thereby, several developmental theories of aggression will be presented. More specifically, theories emphasising biological, psychological and social origins of aggression will be reported. The chapter will finally describe some interventions for aggressive problem behaviour.

Published
2016

48. Epitaxial nucleation and growth of chemically derived Ba2YCu3O7-x thin films on (001) SrTiO3.

Author

McIntyre, P. C., Cima, M. J., and Roshko, A.

Subjects
*NUCLEATION, *DYNAMICS, *THIN films, *ANNEALING of metals
Abstract

Investigates the nucleation and growth kinetics of epitaxial Ba[sub2]YCu[sub3]O[sub7-x] thin films prepared on (001) SrTiO[sub3] by postdeposition annealing of a chemically derived intermediate layer in specimens quenched from the growth anneal. Experimental procedure; Observations of the fully transformed thin films on SrTiO[sub3]; Conclusions.

Published
1995
Full Text
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49. Preparation of biaxially aligned cubic zirconia films on pyrex glass substrates using ion-beam assisted deposition.

Author

Sonnenberg, N., Longo, A. S., Cima, M. J., Chang, B. P., Ressler, K. G., McIntyre, P. C., and Liu, Y. P.

Subjects
ZIRCONIUM, SEMICONDUCTOR films, PYREX, GLASS, PULSED laser deposition
Abstract

Deals with the preparation of biaxially cubic zirconia films on pyrex glass substrates using ion-beam assisted deposition. Experiment conducted; Observations; Discussion.

Published
1993
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50. Cadaver and living donor split liver transplantation from cadaver and living donor in HCV plus recipients: A multicenter experience of an Italian transplant agency

Author

De Feo TM, De Fazio N, Brolese A, Slim A, Rossi G, Colledan M, Andorno E, Baccarani U, Regalia E, Donataccio M, Risaliti A, Cima M, Burra P, Scalamogna M, De Feo, T, De Fazio, N, Brolese, A, Slim, A, Rossi, G, Colledan, M, Andorno, E, Baccarani, U, Regalia, E, Donataccio, M, Risaliti, A, Cima, M, Burra, P, and Scalamogna, M

Subjects
Transplantation, Surgery
Published
2008

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