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Your search keyword '"Cilleruelo, Maria Luz"' showing total 20 results
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20 results on '"Cilleruelo, Maria Luz"'

1. Rational application of the ESPGHAN 2022 recommendations for the follow-up of the paediatric coeliac patient: consensus document of scientific societies (SEGHNP, AEPAP, SEPEAP, SEEC, AEG, SEPD, SEMFYC, SEMG and SEMERGEN)

Author

Roman, Enriqueta, Barrio, Josefa, Cilleruelo, Maria Luz, Torres, Ricardo, Almazán, Vega, Coronel, Cristobal, Espin, Beatriz, Martinez-Ojinaga, Eva, Solís, David Perez, Moreno, Maria Antonia, Reyes, Joaquín, Salazar, Luis Fernandez, Farrais, Sergio, Castillejo, Gemma, Fontanillas, Noelia, Noguerol, Mar, Prieto, Alicia, and Donat, y Ester

Published
2024
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2. Aplicación racional de las recomendaciones ESPGHAN 2022 de seguimiento del paciente celíaco pediátrico: documento de consenso de sociedades científicas (SEGHNP, AEPap, SEPEAP, SEEC, AEG, SEPD, SEMFYC, SEMG y SEMERGEN)

Author

Blanco, Miriam, Miranda, Carmen, Vecino, Raquel, Eizaguirre, Javier, García Calatayud, Salvador, Juste, Mercedes, Sánchez Valverde, Felix, Guardiola, Antonio, Díaz, Xavier, Ribes, Carmen, Polanco, Isabel, Román, Enriqueta, Barrio, Josefa, Cilleruelo, María Luz, Torres, Ricardo, Almazán, Vega, Coronel, Cristobal, Espín, Beatriz, Martínez-Ojinaga, Eva, Pérez Solís, David, Moreno, María Antonia, Reyes, Joaquín, Fernández Salazar, Luis, Farrais, Sergio, Castillejo, Gemma, Fontanillas, Noelia, Noguerol, Mar, Prieto, Alicia, and Donat, Ester

Published
2024
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4. Factors Associated With Decision to Treat or Not to Treat Helicobacter pylori Infection in Children: Data From the EuroPedHp Registry.

Author

Le Thi, Thu Giang, Werkstetter, Katharina, Kotilea, Kallirroi, Bontems, Patrick, Cabral, José, Cilleruelo, Maria Luz, Kori, Michal, Barrio, Josefa, Homan, Matjaž, Kalach, Nicolas, Lima, Rosa, Tavares, Marta, Urruzuno, Pedro, Misak, Zrinjka, Urbonas, Vaidotas, and Koletzko, Sibylle

Subjects
INFLAMMATORY bowel diseases, HELICOBACTER pylori infections, PEDIATRIC therapy, EOSINOPHILIC esophagitis, CHILD patients
Abstract

Background: European and North‐American guidelines on management of H. pylori infection in children provide the option not to treat even if the infection is endoscopically confirmed. We used data from the EuroPedHp Registry to identify factors associated with therapy decisions. Methods: We included treatment‐naïve patients reported between 2017 and 2020 from 30 centers in 17 European countries. Multivariable logistic regression identified factors including comorbidities within and outside the gastrointestinal (GI) tract influencing the decision for or against therapy. Results: Of 1165 patients (52% females, median age 12.8), 28% (321/1165) reported any alarm symptom, 26% (307/1165) comorbidities, and 16% (192/1165) did not receive eradication treatment. Therapy was initiated less often in children having any GI comorbidity (57%, n = 181), particularly in those with eosinophilic esophagitis (60%, n = 35), inflammatory bowel disease (54%, n = 28), and celiac disease (43%, n = 58), compared to those with non‐GI (86%, n = 126) or no comorbidity (89%, n = 858), despite similar frequencies of alarm and non‐alarm symptoms, ulcers, erosions, and nodular gastritis. Patients with GI and without comorbidities remained more likely untreated in high versus low H. pylori prevalence countries (p < 0.0001). In children without comorbidities, factors favoring therapy included older age, being overweight, having symptoms, erosions, antral nodularity, and available antibiotic susceptibility results. Conclusion: In this cohort, H. pylori‐infected children with GI comorbidities compared to no comorbidity showed 75% reduced chance of receiving eradication therapy. We found no evidence supporting different management strategies in infected patients with GI comorbidities compared to all pediatric patients with endoscopically proven H. pylori infection. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Systematic Review and Meta-analysis of Histological Gastric Biopsy Aspects According to the Updated Sydney System in Children

Author

Kalach, Nicolas, Zrinjka, Misak, Bontems, Patrick, Kori, Michal, Homan, Matjaz, Cabral, José, Casswall, Thomas, Chong, Sonny, Cilleruelo, Maria Luz, Faraci, Simona, Megraud, Francis, Papadopoulou, Alexandra, Pehlivanoglu, Ender, Raymond, Josette, Rea, Francesca, Maria, Rogalidou, Roma, Eleftheria, Tavares, Marta, Ugras, Meltem, Urbonas, Vaidotas, Urruzuno, Pedro, Gosset, Pierre, Creusy, Colette, Delebarre, Mathilde, and Verdun, Stephane

Published
2022
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7. Prevalence of Functional Gastrointestinal Disorders in Children and Adolescents in the Mediterranean Region of Europe

Author

Kafritsa, Panayota, Brusa, Sandra, Campanozzi, Angelo, Romano, Claudio, Salvatore, Silvia, Kotzakioulafi, Evelina, Barrio, Josefa, Cilleruelo, Maria Luz, Juste, Mercedes, Gutiérrez-Junquera, Carolina, Trbojević, Tena, Ivković, Lana, Scarpato, Elena, Kolacek, Sanja, Jojkic-Pavkov, Danijela, Konjik, Vlatka, Živković, Nataša, Roman, Enriqueta, Kostovski, Aco, Zdraveska, Nikolina, Altamimi, Eyad, Papadopoulou, Alexandra, Karagiozoglou-Lampoudi, Thomai, Shamir, Raanan, Bar Lev, Michal Rozenfeld, Koleilat, Aziz, Mneimneh, Sirin, Bruzzese, Dario, Leis, Rosaura, and Staiano, Annamaria

Published
2018
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10. Coeliac Disease Case–Control Study: Has the Time Come to Explore beyond Patients at Risk?

Author

Castillejo, Gemma, primary, Ochoa-Sangrador, Carlos, additional, Pérez-Solís, David, additional, Cilleruelo, Maria Luz, additional, Donat, Ester, additional, García-Burriel, Jose Ignacio, additional, Sánchez-Valverde, Félix, additional, Garcia-Calatayud, Salvador, additional, Eizaguirre, Francisco Javier, additional, Martinez-Ojinaga, Eva, additional, Barros, Patricia, additional, Leis, Rosaura, additional, Salazar, Jose Carlos, additional, Barrio, Josefa, additional, Peña-Quintana, Luis, additional, Luque, Verónica, additional, Polanco, Isabel, additional, Ribes, Carmen, additional, and Roman, Enriqueta, additional

Published
2023
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12. Systematic Review and Meta-analysis of Histological Gastric Biopsy Aspects According to the Updated Sydney System in Children

Author

Kalach, Nicolas Zrinjka, Misak Bontems, Patrick Kori, Michal and Homan, Matjaz Cabral, Jose Casswall, Thomas Chong, Sonny and Cilleruelo, Maria Luz Faraci, Simona Megraud, Francis and Papadopoulou, Alexandra Pehlivanoglu, Ender Raymond, Josette and Rea, Francesca Maria, Rogalidou Roma, Eleftheria Tavares, Marta Ugras, Meltem Urbonas, Vaidotas Urruzuno, Pedro and Gosset, Pierre Creusy, Colette Delebarre, Mathilde Verdun, Stephane ESPGHAN-Helicobacter Pylori Specia

Abstract

Objectives: A descriptive and comparative study of gastric histological aspects according to the updated Sydney classification (USC), obtained from Helicobacter pylori-positive versus H pylori-negative children referred for upper gastrointestinal endoscopy. Methods: The Prisma method was used to perform a systematic review and meta-analysis. Selection criteria were based on following key words USC, H pylori, children, endoscopy, or biopsy. Publication biases were assessed according to the Newcastle-Ottawa Scale, and a meta-regression analysis was done. The study was registered on the PROSPERO platform. Results: Between 1994 and 2017, 1238 references were found; 97 studies were retained for the systematic review with a total number of 25,867 children; 75 studies were selected for the meta-analysis concerning 5990 H pylori-infected and 17,782 uninfected children. H pylori-positive versus H pylori-negative children, according to the USC, showed significantly higher relative risk for gastric antral and corpus chronic inflammation, presence of neutrophils, and of lymphoid follicles, and gastric mucosa atrophy, whereas, intestinal metaplasia showed a significantly higher RR only in antral biopsies. The meta-regression analysis showed that H pylori-positive versus H pylori-negative children had significantly higher risk only for corpus activity according to age, recurrent abdominal pain, and geographical area of low H pylori prevalence. Conclusions: H pylori infection in children was associated with higher relative risk for gastric antral and corpus chronic inflammation, presence of neutrophils, lymphoid follicles, and rare gastric mucosa atrophy, whereas, rare intestinal metaplasia was only significantly higher in the antral area.

Published
2022

13. Systematic Review and Meta-analysis of Histological Gastric Biopsy Aspects According to the Updated Sydney System in Children

Author

Kalach, Nicolas, primary, Zrinjka, Misak, additional, Bontems, Patrick, additional, Kori, Michal, additional, Homan, Matjaz, additional, Cabral, José, additional, Casswall, Thomas, additional, Chong, Sonny, additional, Cilleruelo, Maria Luz, additional, Faraci, Simona, additional, Megraud, Francis, additional, Papadopoulou, Alexandra, additional, Pehlivanoglu, Ender, additional, Raymond, Josette, additional, Rea, Francesca, additional, Maria, Rogalidou, additional, Roma, Eleftheria, additional, Tavares, Marta, additional, Ugras, Meltem, additional, Urbonas, Vaidotas, additional, Urruzuno, Pedro, additional, Gosset, Pierre, additional, Creusy, Colette, additional, Delebarre, Mathilde, additional, and Verdun, Stephane, additional

Published
2021
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14. Additional file 1 of Health-related quality of life using specific and generic questionnaires in Spanish coeliac children

Author

Barrio, Josefa, Cilleruelo, Maria Luz, Román, Enriqueta, and Fernández, Cristina

Subjects
nutritional and metabolic diseases, digestive system diseases
Abstract

Additional file 1. Supplemental digital content. Table 1. Health-related quality of life (HRQOL) scores provided by 266 Spanish children with coeliac disease and parents (428) of children with coeliac disease using the specific CDDUX questionnaire. Supplemental digital content. Table 2. Health-related quality of life (HRQOL) scores provided by Spanish children with coeliac disease and parents of children with coeliac disease using the generic KIDSCREEN-52 questionnaire.

Published
2020
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17. Helicobacter pylori Infection in Pediatric Patients Living in Europe: Results of the EuroPedHP Registry 2013 to 2016.

Author

Kori, Michal, Le Thi, Thu Giang, Werkstetter, Katharina, Sustmann, Andrea, Bontems, Patrick, Lopes, Ana Isabel, Oleastro, Monica, Iwanczak, Barbara, Kalach, Nicolas, Misak, Zrinjka, Cabral, José, Homan, Matjaž, Cilleruelo, Maria Luz, Pehlivanoglu, Ender, Casswall, Thomas, Urruzuno, Pedro, Gomez, Maria José Martinez, Papadopoulou, Alexandra, Roma, Eleftheria, and Dolinsek, Jernej

Published
2020
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18. Prevalence of Functional Gastrointestinal Disorders in Children and Adolescents in the Mediterranean Region of Europe

Author

Scarpato, Elena, primary, Kolacek, Sanja, additional, Jojkic-Pavkov, Danijela, additional, Konjik, Vlatka, additional, Živković, Nataša, additional, Roman, Enriqueta, additional, Kostovski, Aco, additional, Zdraveska, Nikolina, additional, Altamimi, Eyad, additional, Papadopoulou, Alexandra, additional, Karagiozoglou-Lampoudi, Thomai, additional, Shamir, Raanan, additional, Bar Lev, Michal Rozenfeld, additional, Koleilat, Aziz, additional, Mneimneh, Sirin, additional, Bruzzese, Dario, additional, Leis, Rosaura, additional, Staiano, Annamaria, additional, Kafritsa, Panayota, additional, Brusa, Sandra, additional, Campanozzi, Angelo, additional, Romano, Claudio, additional, Salvatore, Silvia, additional, Kotzakioulafi, Evelina, additional, Barrio, Josefa, additional, Cilleruelo, Maria Luz, additional, Juste, Mercedes, additional, Gutiérrez-Junquera, Carolina, additional, Trbojević, Tena, additional, and Ivković, Lana, additional

Published
2018
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19. CYP2C19and STAT6Variants Influence the Outcome of Proton Pump Inhibitor Therapy in Pediatric Eosinophilic Esophagitis

Author

Mougey, Edward B., Williams, Andre, Coyne, Ashlan J. Kunz, Gutiérrez-Junquera, Carolina, Fernández-Fernández, Sonia, Cilleruelo, Maria Luz, Rayo, Ana, Echeverría, Luis, Román, Enriqueta, González Lois, Carmen, Chao, Montserrat, Al-Atrash, Hadeel, Lima, John J., and Franciosi, James P.

Abstract

Proton pump inhibitors (PPIs) are an effective treatment for eosinophilic esophagitis (EoE); however, only 30% to 60% of patients respond. Common genetic variants in CYP2C19and STAT6associate with PPI plasma concentration and magnitude of inflammatory response, respectively. Our objective was to determine if genetic variation in the genes for CYP2C19and STAT6influence differentiation between PPI responsive esophageal eosinophilia versus PPI nonresponsive EoE (PPI-REE, PPI-nonresponsive EoE). Genomic DNA was isolated from 92 esophageal tissue biopsies collected from participants of a prospective clinical trial of high-dose PPI therapy for esophageal eosinophilia in children. Of the 92 patients examined, 57 (62%) were PPI-REE and 35 (38%) were PPI-nonresponsive EoE. Forty-six of the 92 patients were further characterized by pH probe monitoring; there was no association between reflux index and carriage of CYP2C19*17(P= 0.35). In children who received a PPI dose between =1.54 and ?2.05 mg/kg/day, binary logistic regression modeling showed that carriage of CYP2C19*17associated with PPI-nonresponsive EoE (odds ratio (OR) [95% confidence interval (CI)] = 7.71 [1.21, 49.11], P= 0.031). Carriage of STAT6allelic variant rs1059513 predicts PPI-REE (OR [95% CI] = 6.16 [1.44, 26.4], P= 0.028), whereas carriage of STAT6rs324011 synergizes with CYP2C19*17to predict PPI-nonresponsive EoE (rs324011 OR [95% CI] = 5.56 [1.33, 20.72], P= 0.022; CYP2C19*17OR [95% CI] = 8.19[1.42, 50.57], P= 0.023). Common variants in CYP2C19and STAT6associate with a PPI-nonresponsive EoE outcome of PPI therapy for esophageal eosinophilia suggesting that response rates may be improved by adopting a genotype-guided approach to PPI dosing.

Published
2019
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