Search

Your search keyword '"Cilla Marta"' showing total 34 results
Start Over Author "Cilla Marta"
34 results on '"Cilla Marta"'

2. Micronized/ultramicronized palmitoylethanolamide improves depression and fatigue in coronavirus disease 2019 (COVID-19) survivors.

Author

Merolla, Aurora, De Lorenzo, Rebecca, Paolazzia, Giacomo, Critelli, Sara, Palladini, Mariagrazia, Damanti, Sarah, Vitali, Giordano, Canti, Valentina, Cilla, Marta, Martinenghi, Sabina, Falbo, Elisabetta, Ferrante, Marica, Castellani, Jacopo, Pacioni, Giacomo, Magnaghi, Cristiano, Fumagalli, Anna, Mazza, Mario G., Benedetti, Francesco, and Rovere-Querini, Patrizia

Published
2024
Full Text
View/download PDF

4. One-year mental health outcomes in a cohort of COVID-19 survivors

Author

Vai, Benedetta, Bollettini, Irene, Melloni, Elisa Maria Teresa, Mazza, Elena Beatrice, Aggio, Veronica, Calesella, Federico, Paolini, Marco, Caselani, Elisa, Colombo, Federica, D’orsi, Greta, Di Pasquasio, Camilla, Fiore, Paola, Calvisi, Stefania, Canti, Valentina, Castellani, Jacopo, Cilla, Marta, Cinel, Elena, Damanti, Sarah, Ferrante, Marica, Martinenghi, Sabina, Santini, Chiara, Vitali, Giordano, Mazza, Mario Gennaro, Palladini, Mariagrazia, De Lorenzo, Rebecca, Bravi, Beatrice, Poletti, Sara, Furlan, Roberto, Ciceri, Fabio, Rovere-Querini, Patrizia, and Benedetti, Francesco

Published
2022
Full Text
View/download PDF

5. SAT-007-YI Assessing sex differences in access to liver transplantation in Italy: a real-world nationwide study

Author

Becchetti, Chiara, primary, Trapani, Silvia, additional, Masiero, Lucia, additional, Puoti, Francesca, additional, D'Arcangelo, Francesca, additional, Lapenna, Lucia, additional, Merli, Manuela, additional, Morisco, Filomena, additional, Cossiga, Valentina, additional, Guarino, Maria, additional, Cilla, Marta, additional, Invernizzi, Federica, additional, Cerutti, Elisabetta, additional, Toniutto, Pierluigi, additional, Cardillo, Massimo, additional, and Burra, Patrizia, additional

Published
2024
Full Text
View/download PDF

7. Secondary infections in patients hospitalized with COVID-19: incidence and predictive factors

Author

Andolina, Andrea, Redaelli, Martina Baiardo, Bigai, Giorgia, Bigoloni, Alba, Borio, Giorgia, Bossolasco, Simona, Bruzzesi, Elena, Calabrò, Maria Grazia, Calvisi, Stefania, Campochiaro, Corrado, Canetti, Diana, Canti, Valentina, Castellani, Jacopo, Castiglioni, Barbara, Cavalli, Giulio, Cavallo, Ludovica, Cernuschi, Massimo, Chiurlo, Matteo, Cilla, Marta, Cinel, Elena, Cinque, Paola, Conte, Caterina, Da Prat, Valentina, Danise, Anna, De Lorenzo, Rebecca, Dell’Acqua, Antonio, Dell’Acqua, Raffaele, Della Torre, Emanuel, Della Torre, Liviana, Di Terlizzi, Gaetano, Dumea, Iulia, Farolfi, Federica, Ferrante, Marica, Frangi, Claudia, Fumagalli, Luca, Gallina, Gabriele, Germinario, Bruno, Gianotti, Nicola, Guffanti, Monica, Hasson, Hamid, Lalla, Francesca, Lanzillotta, Marco, Li Voti, Raffaele, Messina, Emanuela, Molinari, Chiara, Moizo, Elena, Montagna, Marco, Morsica, Giulia, Nozza, Silvia, Pascali, Maria, Patrizi, Alessandro, Pieri, Marina, Poloniato, Antonella, Prestifilippo, Dario, Ramirez, Giuseppe, Ranzenigo, Martina, Sapienza, Jacopo, Seghi, Federico, Tambussi, Giuseppe, Tassan Din, Chiara, Turi, Stefano, Uberti-Foppa, Caterina, Vinci, Concetta, Ripa, Marco, Galli, Laura, Poli, Andrea, Oltolini, Chiara, Spagnuolo, Vincenzo, Mastrangelo, Andrea, Muccini, Camilla, Monti, Giacomo, De Luca, Giacomo, Landoni, Giovanni, Dagna, Lorenzo, Clementi, Massimo, Rovere Querini, Patrizia, Ciceri, Fabio, Tresoldi, Moreno, Lazzarin, Adriano, Zangrillo, Alberto, Scarpellini, Paolo, and Castagna, Antonella

Published
2021
Full Text
View/download PDF

8. Exploring the Association between Delirium and Malnutrition in COVID-19 Survivors: A Geriatric Perspective

Author

Damanti, Sarah, primary, Cilla, Marta, additional, Vitali, Giordano, additional, Tiraferri, Valeria, additional, Pomaranzi, Chiara, additional, De Rubertis, Giulia, additional, De Lorenzo, Rebecca, additional, Di Lucca, Giuseppe, additional, Scotti, Raffaella, additional, Messina, Emanuela, additional, Dell’Acqua, Raffaele, additional, Guffanti, Monica, additional, Cinque, Paola, additional, Castagna, Antonella, additional, Rovere-Querini, Patrizia, additional, and Tresoldi, Moreno, additional

Published
2023
Full Text
View/download PDF

10. Sex is a major effect modifier between body composition and mortality in patients with cirrhosis assessed for liver transplantation

Author

Amine Benmassaoud, Davide Roccarina, Francesco Marcello Arico, Cilla Marta, Rossella Donghia, Gioacchino Leandro, Laura Iogna Prat, Mohamed Zuhair, Matthew North, Orla Kearney, John Ryan, and Emmanuel A. Tsochatzis

Subjects
Hepatology
Abstract

Body composition predicts mortality in patients with cirrhosis. The impact of sex on this association is unknown. We investigated the impact of sex on this association in patients with cirrhosis assessed for liver transplantation.This single-centre retrospective cohort study included adults assessed for liver transplantation. Nutritional status was assessed using the Royal Free Hospital-Global Assessment (RFH-GA). Body composition at the third lumbar vertebrae was determined. SarcopeniaThe cohort comprised 628 patients, including 199 females and 429 males. Both groups were similar in terms of baseline liver disease severity by Model for End-stage Liver Disease (MELD) (p = .98) and nutritional status (p = .24). SarcopeniaThis study demonstrates that male patients were susceptible to low muscle mass, whereas female patients were not. Future research in this patient population should minimize sex-related bias and present data for both groups separately.

Published
2022
Full Text
View/download PDF

11. High Risk of Secondary Infections Following Thrombotic Complications in Patients With COVID-19

Author

Ripa, Marco, Galli, Laura, D’Angelo, Armando, Apruzzi, Luca, Palumbo, Diego, Campochiaro, Corrado, Tassan Din, Chiara, Danise, Anna, Da Prat, Valentina, Vitali, Giordano, Brugliera, Luigia, Poli, Andrea, Monardo, Roberta, Monti, Giacomo, Baccellieri, Domenico, De Cobelli, Francesco, Clementi, Massimo, Iannaccone, Sandro, Dagna, Lorenzo, Rovere-Querini, Patrizia, Ciceri, Fabio, Tresoldi, Moreno, Zangrillo, Alberto, Scarpellini, Paolo, Castagna, Antonella, Andolina, Andrea, Bigoloni, Alba, Bossolasco, Simona, Bruzzesi, Elena, Canetti, Diana, Castiglioni, Barbara, Cernuschi, Massimo, Chiurlo, Matteo, Cinque, Paola, Dell’Acqua, Raffaele, Della Torre, Liviana, Gianotti, Nicola, Guffanti, Monica, Hasson, Hamid, Messina, Emanuela, Morsica, Giulia, Nozza, Silvia, Ranzenigo, Martina, Uberti-Foppa, Caterina, Vinci, Concetta, Badalucco Ciotta, Flavia, Bottanelli, Martina, Clemente, Tommaso, Mainardi, Ilaria, Mori, Giovanni, Papaioannu Borjesson, Rebecka, Ponta, Giacomo, Muccini, Camilla, Mastrangelo, Andrea, Oltolini, Chiara, Spagnuolo, Vincenzo, Benassi, Luca, Bigai, Giorgia, Bozzolo, Enrica, Borio, Giorgia, Bussolari, Cecilia, Calvisi, Stefania, Canti, Valentina, Castellani, Jacopo, Cavallo, Ludovica, Cilla, Marta, Cinel, Elena, Compagnone, Nicola, D’Aliberti, Teresa, Damanti, Sarah, De Lorenzo, Rebecca, Di Lucca, Giuseppe, Di Terlizzi, Gaetano, Dumea, Iulia, Farolfi, Federica, Ferrante, Marica, Frangi, Claudia, Gallina, Gabriele, Germinario Bruno, Nicolò, Lanzillotta, Marco, Li Voti, Raffaele, Marinosci, Alessandro, Martinenghi, Sabina, Memoli, Massimo, Montagna, Marco, Pascali, Maria, Patrizi, Alessandro, Pomaranzi, Chiara, Scotti, Raffaella, Strada, Silvia, Boffini, Nicola, Cavalli, Giulio, Della Torre, Emanuel, De Luca, Giacomo, Farina, Nicola, Moroni, Luca, Ramirez Giuseppe, Alvise, Tomelleri, Alessandro, Azzolini Maria, Luisa, Baiardo Redaelli, Martina, Calabrò Maria, Grazia, Casiraghi Giuseppina, Maria, Dell’Acqua, Antonio, Fresilli, Stefano, Guzzo, Francesca, Landoni, Giovanni, Lombardi, Gaetano, Maimeri, Nicolò, Moizo, Elena, Nisi Francesco, Giuseppe, Oriani, Alessandro, Ortalda, Alessandro, Pasculli, Nicola, Pieri, Marina, Turi, Stefano, Bertoglio, Luca, Bilman, Victor, Carletti, Silvia, Gona, Floriana, Mancini, Nicasio, Della Valle, Patrizia, Molinari, Chiara, Poloniato, Antonella, Lalla, Francesca, Prestifilippo, Dario, Sapienza, Jacopo, Seghi, Federico, Ripa, Marco, Galli, Laura, D’Angelo, Armando, Apruzzi, Luca, Palumbo, Diego, Campochiaro, Corrado, Tassan Din, Chiara, Danise, Anna, Da Prat, Valentina, Vitali, Giordano, Brugliera, Luigia, Poli, Andrea, Monardo, Roberta, Monti, Giacomo, Baccellieri, Domenico, De Cobelli, Francesco, Clementi, Massimo, Iannaccone, Sandro, Dagna, Lorenzo, Rovere-Querini, Patrizia, Ciceri, Fabio, Tresoldi, Moreno, Zangrillo, Alberto, Scarpellini, Paolo, Castagna, Antonella, Andolina, Andrea, Bigoloni, Alba, Bossolasco, Simona, Bruzzesi, Elena, Canetti, Diana, Castiglioni, Barbara, Cernuschi, Massimo, Chiurlo, Matteo, Cinque, Paola, Dell’Acqua, Raffaele, Della Torre, Liviana, Gianotti, Nicola, Guffanti, Monica, Hasson, Hamid, Messina, Emanuela, Morsica, Giulia, Nozza, Silvia, Ranzenigo, Martina, Uberti-Foppa, Caterina, Vinci, Concetta, Badalucco Ciotta, Flavia, Bottanelli, Martina, Clemente, Tommaso, Mainardi, Ilaria, Mori, Giovanni, Papaioannu Borjesson, Rebecka, Ponta, Giacomo, Muccini, Camilla, Mastrangelo, Andrea, Oltolini, Chiara, Spagnuolo, Vincenzo, Benassi, Luca, Bigai, Giorgia, Bozzolo, Enrica, Borio, Giorgia, Bussolari, Cecilia, Calvisi, Stefania, Canti, Valentina, Castellani, Jacopo, Cavallo, Ludovica, Cilla, Marta, Cinel, Elena, Compagnone, Nicola, D’Aliberti, Teresa, Damanti, Sarah, De Lorenzo, Rebecca, Di Lucca, Giuseppe, Di Terlizzi, Gaetano, Dumea, Iulia, Farolfi, Federica, Ferrante, Marica, Frangi, Claudia, Gallina, Gabriele, Germinario Bruno, Nicolò, Lanzillotta, Marco, Li Voti, Raffaele, Marinosci, Alessandro, Martinenghi, Sabina, Memoli, Massimo, Montagna, Marco, Pascali, Maria, Patrizi, Alessandro, Pomaranzi, Chiara, Scotti, Raffaella, Strada, Silvia, Boffini, Nicola, Cavalli, Giulio, Della Torre, Emanuel, De Luca, Giacomo, Farina, Nicola, Moroni, Luca, Ramirez Giuseppe, Alvise, Tomelleri, Alessandro, Azzolini Maria, Luisa, Baiardo Redaelli, Martina, Calabrò Maria, Grazia, Casiraghi Giuseppina, Maria, Dell’Acqua, Antonio, Fresilli, Stefano, Guzzo, Francesca, Landoni, Giovanni, Lombardi, Gaetano, Maimeri, Nicolò, Moizo, Elena, Nisi Francesco, Giuseppe, Oriani, Alessandro, Ortalda, Alessandro, Pasculli, Nicola, Pieri, Marina, Turi, Stefano, Bertoglio, Luca, Bilman, Victor, Carletti, Silvia, Gona, Floriana, Mancini, Nicasio, Della Valle, Patrizia, Molinari, Chiara, Poloniato, Antonella, Lalla, Francesca, Prestifilippo, Dario, Sapienza, Jacopo, and Seghi, Federico

Subjects
pulmonary embolism, Infectious Diseases, Oncology, bacteria, coronavirus, infections, thrombosis
Abstract

BackgroundThis study’s primary aim was to evaluate the impact of thrombotic complications on the development of secondary infections. The secondary aim was to compare the etiology of secondary infections in patients with and without thrombotic complications.MethodsThis was a cohort study (NCT04318366) of coronavirus disease 2019 (COVID-19) patients hospitalized at IRCCS San Raffaele Hospital between February 25 and June 30, 2020. Incidence rates (IRs) were calculated by univariable Poisson regression as the number of cases per 1000 person-days of follow-up (PDFU) with 95% confidence intervals. The cumulative incidence functions of secondary infections according to thrombotic complications were compared with Gray's method accounting for competing risk of death. A multivariable Fine-Gray model was applied to assess factors associated with risk of secondary infections.ResultsOverall, 109/904 patients had 176 secondary infections (IR, 10.0; 95% CI, 8.8–11.5; per 1000-PDFU). The IRs of secondary infections among patients with or without thrombotic complications were 15.0 (95% CI, 10.7–21.0) and 9.3 (95% CI, 7.9–11.0) per 1000-PDFU, respectively (P = .017). At multivariable analysis, thrombotic complications were associated with the development of secondary infections (subdistribution hazard ratio, 1.788; 95% CI, 1.018–3.140; P = .043). The etiology of secondary infections was similar in patients with and without thrombotic complications.ConclusionsIn patients with COVID-19, thrombotic complications were associated with a high risk of secondary infections.

Published
2022
Full Text
View/download PDF

13. Predictors and outcomes of delirium in the emergency department during the first wave of the COVID-19 pandemic in Milan

Author

Damanti, Sarah, primary, Bozzolo, Enrica, additional, Franchini, Stefano, additional, Frangi, Claudia, additional, Ramirez, Giuseppe Alvise, additional, Pedroso, Carla, additional, Di Lucca, Giuseppe, additional, Scotti, Raffaella, additional, Valsecchi, Davide, additional, Cilla, Marta, additional, Cinel, Elena, additional, Santini, Chiara, additional, Castellani, Jacopo, additional, Manzo, Emanuela, additional, Vadruccio, Stefania, additional, Spessot, Marzia, additional, Borghi, Giovanni, additional, Monti, Giacomo, additional, Landoni, Giovanni, additional, Rovere-Querini, Patrizia, additional, Yacoub, Mona-Rita, additional, and Tresoldi, Moreno, additional

Published
2022
Full Text
View/download PDF

14. Physical and psychological sequelae at three months after acute illness in COVID-19 survivors.

Author

DE LORENZO, Rebecca, CINEL, Elena, CILLA, Marta, COMPAGNONE, Nicola, FERRANTE, Marica, FALBO, Elisabetta, PATRIZI, Alessandro, CASTELLANI, Jacopo, MAGNAGHI, Cristiano, CALVISI, Stefania L., ARCIDIACONO, Teresa, LANZANI, Chiara, CANTI, Valentina, MAZZA, Mario G., MARTINENGHI, Sabina, VITALI, Giordano, BENEDETTI, Francesco, CICERI, Fabio, CONTE, Caterina, and ROVERE QUERINI, Patrizia

Published
2023
Full Text
View/download PDF

15. Prevalence of Long COVID-19 Symptoms After Hospital Discharge in Frail and Robust Patients

Author

Damanti, Sarah, primary, Cilla, Marta, additional, Cilona, Maria, additional, Fici, Aldo, additional, Merolla, Aurora, additional, Pacioni, Giacomo, additional, De Lorenzo, Rebecca, additional, Martinenghi, Sabina, additional, Vitali, Giordano, additional, Magnaghi, Cristiano, additional, Fumagalli, Anna, additional, Gennaro Mazza, Mario, additional, Benedetti, Francesco, additional, Tresoldi, Moreno, additional, and Rovere Querini, Patrizia, additional

Published
2022
Full Text
View/download PDF

17. A Pilot Study of the Efficacy and Economical Sustainability of Acute Coronavirus Disease 2019 Patient Management in an Outpatient Setting

Author

De Lorenzo, Rebecca, primary, Montagna, Marco, additional, Bossi, Eleonora, additional, Vitali, Giordano, additional, Taino, Alba, additional, Cilla, Marta, additional, Pata, Giulia, additional, Lazorova, Ludmilla, additional, Pesenti, Riccardo, additional, Pomaranzi, Chiara, additional, Bussolari, Cecilia, additional, Martinenghi, Sabina, additional, Bordonaro, Nicoletta, additional, Di Napoli, Davide, additional, Rizzardini, Giuliano, additional, Cogliati, Chiara, additional, Morici, Nuccia, additional, and Rovere-Querini, Patrizia, additional

Published
2022
Full Text
View/download PDF

18. Myosteatosis Significantly Predicts Persistent Dyspnea and Mobility Problems in COVID-19 Survivors

Author

De Lorenzo, Rebecca, primary, Palmisano, Anna, additional, Esposito, Antonio, additional, Gnasso, Chiara, additional, Nicoletti, Valeria, additional, Leone, Riccardo, additional, Vignale, Davide, additional, Falbo, Elisabetta, additional, Ferrante, Marica, additional, Cilla, Marta, additional, Magnaghi, Cristiano, additional, Martinenghi, Sabina, additional, Vitali, Giordano, additional, Molfino, Alessio, additional, Rovere-Querini, Patrizia, additional, Muscaritoli, Maurizio, additional, and Conte, Caterina, additional

Published
2022
Full Text
View/download PDF

19. A Nomogram-Based Model to Predict Respiratory Dysfunction at 6 Months in Non-Critical COVID-19 Survivors

Author

De Lorenzo, Rebecca, primary, Magnaghi, Cristiano, additional, Cinel, Elena, additional, Vitali, Giordano, additional, Martinenghi, Sabina, additional, Mazza, Mario G., additional, Nocera, Luigi, additional, Cilla, Marta, additional, Damanti, Sarah, additional, Compagnone, Nicola, additional, Ferrante, Marica, additional, Conte, Caterina, additional, Benedetti, Francesco, additional, Ciceri, Fabio, additional, and Rovere-Querini, Patrizia, additional

Published
2022
Full Text
View/download PDF

20. Evaluation of Muscle Mass and Stiffness with Limb Ultrasound in COVID-19 Survivors

Author

Damanti, Sarah, primary, Cilla, Marta, additional, Tuscano, Bruno, additional, De Lorenzo, Rebecca, additional, Manganaro, Giuseppina, additional, Merolla, Aurora, additional, Pacioni, Giacomo, additional, Pomaranzi, Chiara, additional, Tiraferri, Valeria, additional, Martinenghi, Sabina, additional, Vitali, Giordano, additional, Bosi, Emanuele, additional, Conte, Caterina, additional, Giustina, Andrea, additional, Tresoldi, Moreno, additional, and Rovere Querini, Patrizia, additional

Published
2022
Full Text
View/download PDF

21. One-year mental health outcomes in a cohort of COVID-19 survivors

Author

Mazza, Mario Gennaro, primary, Palladini, Mariagrazia, additional, De Lorenzo, Rebecca, additional, Bravi, Beatrice, additional, Poletti, Sara, additional, Furlan, Roberto, additional, Ciceri, Fabio, additional, Rovere-Querini, Patrizia, additional, Benedetti, Francesco, additional, Vai, Benedetta, additional, Bollettini, Irene, additional, Melloni, Elisa Maria Teresa, additional, Mazza, Elena Beatrice, additional, Aggio, Veronica, additional, Calesella, Federico, additional, Paolini, Marco, additional, Caselani, Elisa, additional, Colombo, Federica, additional, D’orsi, Greta, additional, Di Pasquasio, Camilla, additional, Fiore, Paola, additional, Calvisi, Stefania, additional, Canti, Valentina, additional, Castellani, Jacopo, additional, Cilla, Marta, additional, Cinel, Elena, additional, Damanti, Sarah, additional, Ferrante, Marica, additional, Martinenghi, Sabina, additional, Santini, Chiara, additional, and Vitali, Giordano, additional

Published
2022
Full Text
View/download PDF

22. Predictors and outcomes of delirium in the emergency department during the first wave of the COVID-19 pandemic in Milan.

Author

Damanti, Sarah, Bozzolo, Enrica, Franchini, Stefano, Frangi, Claudia, Ramirez, Giuseppe Alvise, Pedroso, Carla, Di Lucca, Giuseppe, Scotti, Raffaella, Valsecchi, Davide, Cilla, Marta, Cinel, Elena, Santini, Chiara, Castellani, Jacopo, Manzo, Emanuela, Vadruccio, Stefania, Spessot, Marzia, Borghi, Giovanni, Monti, Giacomo, Landoni, Giovanni, and Rovere-Querini, Patrizia

Published
2023
Full Text
View/download PDF

23. Saliva molecular testing for SARS-CoV-2: simplifying the diagnosis without losing accuracy

Author

Saluzzo, Francesca, primary, Mantegani, Paola, additional, Poletti de Chaurand, Valeria, additional, Cugnata, Federica, additional, Rovere-Querini, Patrizia, additional, Cilla, Marta, additional, Erba, Patrizia Paola, additional, Racca, Sara, additional, Tresoldi, Cristina, additional, Uberti-Foppa, Caterina, additional, Di Serio, Clelia, additional, and Cirillo, Daniela Maria, additional

Published
2021
Full Text
View/download PDF

24. Physical and psychological sequelae at three months after acute illness in COVID-19 survivors

Author

De Lorenzo, Rebecca, primary, Cinel, Elena, additional, Cilla, Marta, additional, Compagnone, Nicola, additional, Ferrante, Marica, additional, Falbo, Elisabetta, additional, Patrizi, Alessandro, additional, Castellani, Jacopo, additional, Magnaghi, Cristiano, additional, Calvisi, Stefania L., additional, Arcidiacono, Teresa, additional, Lanzani, Chiara L., additional, Canti, Valentina, additional, Mazza, Mario G., additional, Martinenghi, Sabina, additional, Vitali, Giordano, additional, Benedetti, Francesco, additional, Ciceri, Fabio, additional, Conte, Caterina, additional, and Rovere Querini, Patrizia, additional

Published
2021
Full Text
View/download PDF

25. Secondary infections in patients hospitalized with COVID-19: incidence and predictive factors

Author

Ripa, Marco, primary, Galli, Laura, additional, Poli, Andrea, additional, Oltolini, Chiara, additional, Spagnuolo, Vincenzo, additional, Mastrangelo, Andrea, additional, Muccini, Camilla, additional, Monti, Giacomo, additional, De Luca, Giacomo, additional, Landoni, Giovanni, additional, Dagna, Lorenzo, additional, Clementi, Massimo, additional, Rovere Querini, Patrizia, additional, Ciceri, Fabio, additional, Tresoldi, Moreno, additional, Lazzarin, Adriano, additional, Zangrillo, Alberto, additional, Scarpellini, Paolo, additional, Castagna, Antonella, additional, Andolina, Andrea, additional, Redaelli, Martina Baiardo, additional, Bigai, Giorgia, additional, Bigoloni, Alba, additional, Borio, Giorgia, additional, Bossolasco, Simona, additional, Bruzzesi, Elena, additional, Calabrò, Maria Grazia, additional, Calvisi, Stefania, additional, Campochiaro, Corrado, additional, Canetti, Diana, additional, Canti, Valentina, additional, Castellani, Jacopo, additional, Castiglioni, Barbara, additional, Cavalli, Giulio, additional, Cavallo, Ludovica, additional, Cernuschi, Massimo, additional, Chiurlo, Matteo, additional, Cilla, Marta, additional, Cinel, Elena, additional, Cinque, Paola, additional, Conte, Caterina, additional, Da Prat, Valentina, additional, Danise, Anna, additional, De Lorenzo, Rebecca, additional, Dell’Acqua, Antonio, additional, Dell’Acqua, Raffaele, additional, Della Torre, Emanuel, additional, Della Torre, Liviana, additional, Di Terlizzi, Gaetano, additional, Dumea, Iulia, additional, Farolfi, Federica, additional, Ferrante, Marica, additional, Frangi, Claudia, additional, Fumagalli, Luca, additional, Gallina, Gabriele, additional, Germinario, Bruno, additional, Gianotti, Nicola, additional, Guffanti, Monica, additional, Hasson, Hamid, additional, Lalla, Francesca, additional, Lanzillotta, Marco, additional, Li Voti, Raffaele, additional, Messina, Emanuela, additional, Molinari, Chiara, additional, Moizo, Elena, additional, Montagna, Marco, additional, Morsica, Giulia, additional, Nozza, Silvia, additional, Pascali, Maria, additional, Patrizi, Alessandro, additional, Pieri, Marina, additional, Poloniato, Antonella, additional, Prestifilippo, Dario, additional, Ramirez, Giuseppe, additional, Ranzenigo, Martina, additional, Sapienza, Jacopo, additional, Seghi, Federico, additional, Tambussi, Giuseppe, additional, Tassan Din, Chiara, additional, Turi, Stefano, additional, Uberti-Foppa, Caterina, additional, and Vinci, Concetta, additional

Published
2021
Full Text
View/download PDF

26. Invasive Pulmonary Aspergillosis Complicated by Carbapenem-Resistant Pseudomonas aeruginosa Infection During Pembrolizumab Immunotherapy for Metastatic Lung Adenocarcinoma: Case Report and Review of the Literature

Author

Oltolini, Chiara, primary, Ripa, Marco, additional, Andolina, Andrea, additional, Brioschi, Elena, additional, Cilla, Marta, additional, Petrella, Giovanna, additional, Gregorc, Vanesa, additional, Castiglioni, Barbara, additional, Tassan Din, Chiara, additional, and Scarpellini, Paolo, additional

Published
2018
Full Text
View/download PDF

27. A Nomogram-Based Model to Predict Respiratory Dysfunction at 6 Months in Non-Critical COVID-19 Survivors

Author

Rebecca, De Lorenzo, Cristiano, Magnaghi, Elena, Cinel, Giordano, Vitali, Sabina, Martinenghi, Mario G, Mazza, Luigi, Nocera, Marta, Cilla, Sarah, Damanti, Nicola, Compagnone, Marica, Ferrante, Caterina, Conte, Francesco, Benedetti, Fabio, Ciceri, Patrizia, Rovere-Querini, De Lorenzo, Rebecca, Magnaghi, Cristiano, Cinel, Elena, Vitali, Giordano, Martinenghi, Sabina, Mazza, Mario G, Nocera, Luigi, Cilla, Marta, Damanti, Sarah, Compagnone, Nicola, Ferrante, Marica, Conte, Caterina, Benedetti, Francesco, Ciceri, Fabio, and Rovere-Querini, Patrizia

Subjects
prediction algorithm, long-term, respiratory sequelae, follow-up, COVID-19, General Medicine
Abstract

ObjectiveTo assess the prevalence of respiratory sequelae of Coronavirus disease 2019 (COVID-19) survivors at 6 months after hospital discharge and develop a model to identify at-risk patients.Patients and MethodsIn this prospective cohort study, hospitalized, non-critical COVID-19 patients evaluated at 6-month follow-up between 26 August, 2020 and 16 December, 2020 were included. Primary outcome was respiratory dysfunction at 6 months, defined as at least one among tachypnea at rest, percent predicted 6-min walking distance at 6-min walking test (6MWT) ≤ 70%, pre-post 6MWT difference in Borg score ≥ 1 or a difference between pre- and post-6MWT oxygen saturation ≥ 5%. A nomogram-based multivariable logistic regression model was built to predict primary outcome. Validation relied on 2000-resample bootstrap. The model was compared to one based uniquely on degree of hypoxemia at admission.ResultsOverall, 316 patients were included, of whom 118 (37.3%) showed respiratory dysfunction at 6 months. The nomogram relied on sex, obesity, chronic obstructive pulmonary disease, degree of hypoxemia at admission, and non-invasive ventilation. It was 73.0% (95% confidence interval 67.3–78.4%) accurate in predicting primary outcome and exhibited minimal departure from ideal prediction. Compared to the model including only hypoxemia at admission, the nomogram showed higher accuracy (73.0 vs 59.1%, P < 0.001) and greater net-benefit in decision curve analyses. When the model included also respiratory data at 1 month, it yielded better accuracy (78.2 vs. 73.2%) and more favorable net-benefit than the original model.ConclusionThe newly developed nomograms accurately identify patients at risk of persistent respiratory dysfunction and may help inform clinical priorities.

Published
2022
Full Text
View/download PDF

28. Physical and psychological sequelae at three months after acute illness in COVID-19 survivors

Author

Patrizia Rovere Querini, Francesco Benedetti, S. Martinenghi, Caterina Conte, Elisabetta Falbo, Cristiano Magnaghi, Mario Gennaro Mazza, Valentina Canti, Nicola Compagnone, Marica Ferrante, Giordano Vitali, Jacopo Castellani, Rebecca De Lorenzo, Marta Cilla, Stefania Calvisi, Alessandro Patrizi, Teresa Arcidiacono, Chiara Lanzani, Fabio Ciceri, Elena Cinel, DE Lorenzo, Rebecca, Cinel, Elena, Cilla, Marta, Compagnone, Nicola, Ferrante, Marica, Falbo, Elisabetta, Patrizi, Alessandro, Castellani, Jacopo, Magnaghi, Cristiano, Calvisi, Stefania L, Arcidiacono, Teresa, Lanzani, Chiara L, Canti, Valentina, Mazza, Mario G, Martinenghi, Sabina, Vitali, Giordano, Benedetti, Francesco, Ciceri, Fabio, Conte, Caterina, and Rovere Querini, Patrizia

Subjects
medicine.medical_specialty, business.industry, General Medicine, Odds ratio, Logistic regression, Tachypnea, Confidence interval, Quality of life, Internal medicine, Insomnia, Medicine, Anxiety, medicine.symptom, business, Cohort study
Abstract

BACKGROUND: Coronavirus disease 2019 (COVID-19) may leave behind an altered health status early after recovery. We evaluated the clinical status of COVID-19 survivors at three months after hospital discharge. METHODS: In this prospective observational cohort study, hospitalized patients aged ≥18 years, evaluated at one (M1) and three (M3) months post-discharge were enrolled. 251 patients (71.3% males, median [IQR] age 61.8 [53.5-70.7] years) were included. Median (IQR) time from discharge to M3 was 89 (79.5-101) days. Primary outcome was residual respiratory dysfunction (RRD), defined by tachypnea, moderate to very severe dyspnea, or peripheral oxygen saturation ≤95% on room air at M3. RESULTS: RRD was found in 30.4% of patients, with no significant difference compared with M1. Chronic obstructive pulmonary disease and length of stay were independent predictors of RRD at multivariable logistic regression (odds ratio, OR, [95% confidence interval, CI] 4.13 [1.17-16.88], p 0.033; OR [95% CI] 1.02 [1.00-1.04], p 0.047, respectively). Obesity and C-reactive protein levels upon admission were additional predictors at regression tree analysis. Impaired quality of life (QoL) was reported by 53.2% of patients. Anxiety and insomnia were each present in 25.5% of patients, and PTSD in 22.4%. No difference was found between M1 and M3 in QoL, anxiety or PTSD. Insomnia decreased at M3. Current major psychiatric disorder as well as anxiety, insomnia and PSTD at M1 independently predicted PTSD at M3. CONCLUSIONS: Clinical damage may persist at three months after discharge in COVID-19 survivors. Post-recovery follow-up is an essential component of patient management.

Published
2021
Full Text
View/download PDF

29. Invasive Pulmonary Aspergillosis Complicated by Carbapenem-Resistant Pseudomonas aeruginosa Infection During Pembrolizumab Immunotherapy for Metastatic Lung Adenocarcinoma: Case Report and Review of the Literature

Author

Chiara Oltolini, Marco Ripa, Barbara Castiglioni, Andrea Andolina, Marta Cilla, Elena Brioschi, Vanesa Gregorc, Paolo Scarpellini, Giovanna Petrella, Chiara Tassan Din, Oltolini, Chiara, Ripa, Marco, Andolina, Andrea, Brioschi, Elena, Cilla, Marta, Petrella, Giovanna, Gregorc, Vanesa, Castiglioni, Barbara, Tassan Din, Chiara, and Scarpellini, Paolo

Subjects
0301 basic medicine, medicine.medical_specialty, Drug-Related Side Effects and Adverse Reactions, Veterinary (miscellaneous), medicine.medical_treatment, 030106 microbiology, Adenocarcinoma of Lung, Pembrolizumab, Programmed death-1/programmed death-1 ligand-targeted agent, Antibodies, Monoclonal, Humanized, medicine.disease_cause, Aspergillosis, Applied Microbiology and Biotechnology, Microbiology, Opportunistic infection, 030207 dermatology & venereal diseases, 03 medical and health sciences, Antineoplastic Agents, Immunological, 0302 clinical medicine, Adrenal Cortex Hormones, Prednisone, Drug Resistance, Multiple, Bacterial, Internal medicine, medicine, Humans, Opportunistic infections, Pseudomonas Infections, Pneumonitis, Invasive Pulmonary Aspergillosis, business.industry, Cancer, Invasive pulmonary aspergillosi, Immunotherapy, Middle Aged, medicine.disease, Superinfection, Pseudomonas aeruginosa, Female, Programmed death-1/programmed death-1 ligand-targeted agents, Nivolumab, business, Agronomy and Crop Science, Immunosuppressive Agents, Metastatic lung cancer, medicine.drug
Abstract

The widespread use of T lymphocyte-associated antigen-4 (CTLA-4) and programmed death (PD)-1 and PD ligand-1 (PDL1)-targeted agents in cancer patients as immunotherapy has raised some issues on their safety profile. Regarding infectious complications, it has emerged that these compounds do not intrinsically increase susceptibility to opportunistic infections, which mainly correlate with the co-administration of systemic immunosuppressive therapy (high-dose corticosteroids and anti-tumor necrosis factors inhibitors) to cure immune-related adverse events (colitis, hepatitis, pneumonitis and pancreatitis), well-known complications of these targeted drugs. These observations lead experts' opinion to suggest primary anti-Pneumocystis prophylaxis in patients undergoing CTLA-4 and PD-1/PDL1 agents who will receive prednisone 20 mg daily for ≥ 4 weeks. Few data on invasive fungal infections in this context are available. We report here a case of probable invasive pulmonary aspergillosis (p-IPA) complicating first-line immunotherapy with pembrolizumab for metastatic lung cancer that was further aggravated by multidrug-resistant Pseudomonas aeruginosa superinfection of fungal cavities; the patient received concurrent systemic corticosteroid therapy as anti-edema treatment for cerebral metastases. Reviewing literature about Aspergillus diseases in subjects receiving CTLA-4 and PD-1 and PDL1-targeted agents, we found three cases of invasive aspergillosis and one case of exacerbation of chronic progressive pulmonary aspergillosis after nivolumab treatment; to the best of our knowledge, this is the first report of p-IPA complicating pembrolizumab immunotherapy. Briefly, in this new setting of biological/targeted drugs, waiting for growing clinical experience, we recommend a high level of alertness in diagnosing any infectious complications.

Published
2018
Full Text
View/download PDF

30. Liver Transplantation in Patients with Alcohol-Associated Liver Disease : Current Strategies and Future Perspectives

Author

Invernizzi, Federica and Cilla, Marta

Subjects
Medical
Abstract

Patients with alcohol-related liver disease (ALD) who receive a liver transplant (LT) reach a one-year post LT survival of 80–85%. The rule of abstinence from alcohol for 6 months before transplantation has been applied widely, but few data support the use of this rule as the only criterion for selecting LT candidates. Today, many liver transplant centers try to balance the duration of abstinence against the risk of death associated with the severity of ALD. Since 2011, an increasing number of papers suggests that transplantation without a specific period of abstinence (early LT) among patients with severe and nonmedical-therapy responder alcoholic hepatitis is an effective therapeutic strategy. Further data are needed to better define the selection of patients with ALD who have been abstinent for less than 6 months as suitable LT candidates and to improve the treatment of alcohol use disorder in those patients who have received a LT reducing the risk of alcohol abuse recurrence.

Published
2018

31. Sex disparities in acute-on-chronic liver failure: From admission to the intensive care unit to liver transplantation.

Author

Cerutti E, D'Arcangelo F, Becchetti C, Cilla M, Cossiga V, Guarino M, Invernizzi F, Lapenna L, Lavezzo B, Marra F, Merli M, Morelli MC, Toniutto P, Burra P, and Zanetto A

Abstract

Acute-on-chronic liver failure (ACLF) is a severe clinical syndrome characterized by acute liver decompensation in patients with chronic liver disease, marked by systemic inflammation and systemic organ failure. In this review, we discussed sex-related disparities in the incidence, prognosis, and access to liver transplantation (LT) for patients with ACLF, particularly during Intensive Care Unit (ICU) management. Some studies have suggested that ACLF is more prevalent among male patients admitted to the ICU, and they have higher mortality rates than females. Available prognostic scores, such as CLIF-C or TAM-score, lack sex-specific adjustments. Sarcopenia seems to enhance the accuracy of these scores though this is observed only in male individuals. LT is the only effective treatment for patients with ACLF grade 2-3 who do not respond to medical therapies. Sex-related disparities occur in both access to LT and post-transplant outcomes, although the influence of sex on the prevalence, clinical course, and listing for LT in ACLF remains largely undetermined. A sex-orientated analysis of ICU outcomes in ACLF would facilitate the development of sex-orientated management strategies, thereby improving patients' outcomes., Competing Interests: Declaration of competing interest On behalf of all Authors, we confirm that we have no conflict of interest to disclose., (Copyright © 2024 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)

Published
2024
Full Text
View/download PDF

33. Predictors and outcomes of delirium in the emergency department during the first wave of the COVID-19 pandemic in Milan.

Author

Damanti S, Bozzolo E, Franchini S, Frangi C, Ramirez GA, Pedroso C, Di Lucca G, Scotti R, Valsecchi D, Cilla M, Cinel E, Santini C, Castellani J, Manzo E, Vadruccio S, Spessot M, Borghi G, Monti G, Landoni G, Rovere-Querini P, Yacoub MR, and Tresoldi M

Subjects
Humans, Adolescent, Retrospective Studies, SARS-CoV-2, Pandemics, Emergency Service, Hospital, COVID-19 epidemiology, Delirium complications, Delirium epidemiology, Dementia complications
Abstract

Background: Respiratory infections can be complicated by acute brain failure. We assessed delirium prevalence, predictors and outcomes in COVID-19 ED patients., Methods: This was a retrospective observational study conducted at the San Raffaele ED (Italy). Patients age >18 years attending the ED between 26 February 2020 and 30 May 2020 and who had a positive molecular nasopharyngeal swab for SARS-CoV-2 were included. The Chart-Based Delirium Identification Instrument (CHART-DEL) was used to retrospectively assess delirium. Univariable and multivariable logistic regression analyses were used to evaluate delirium predictors. Univariable binary logistic regression analyses, linear regression analyses and Cox regression analyses were used to assess the association between delirium and clinical outcomes. Age-adjusted and sex-adjusted models were then run for the significant predictors of the univariable models., Results: Among the 826 included patients, 123 cases (14.9%) of delirium were retrospectively detected through the CHART-DEL method. Patients with delirium were older (76.9±13.15 vs 61.3±14.27 years, p<0.001) and more frequently living in a long-term health facility (32 (26%) vs 22 (3.1%), p<0.001). Age (OR 1.06, 95% CI 1.04 to 1.09, p<0.001), dementia (OR 17.5, 95% CI 7.27 to 42.16, p<0.001), epilepsy (OR 6.96, 95% CI 2.48 to 19.51, p<0.001) and the number of chronic medications (OR 1.09, 95% CI 1.01 to 1.17, p=0.03) were significant predictors of delirium in multivariable analyses. Delirium was associated with increased in-hospital mortality (adjusted HR 2.16, 95% CI 1.55 to 3.03, p<0.001) and with a reduced probability of being discharged home compared with being institutionalised (adjusted OR 0.39, 95% CI 0.25 to 0.61, p<0.001)., Conclusions: Chart review frequently identified ED delirium in patients with COVID-19. Age, dementia, epilepsy and polypharmacy were significant predictors of ED delirium. Delirium was associated with an increased in-hospital mortality and with a reduced probability of being discharged home after hospitalisation. The findings of this single-centre retrospective study require validation in future studies., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2023
Full Text
View/download PDF

34. Sex is a major effect modifier between body composition and mortality in patients with cirrhosis assessed for liver transplantation.

Author

Benmassaoud A, Roccarina D, Arico FM, Cilla M, Donghia R, Leandro G, Prat LI, Zuhair M, North M, Kearney O, Ryan J, and Tsochatzis EA

Subjects
Adult, Humans, Male, Female, Retrospective Studies, Severity of Illness Index, Liver Cirrhosis complications, Muscle, Skeletal, Psoas Muscles, Body Composition, Liver Transplantation adverse effects, Sarcopenia complications, End Stage Liver Disease etiology
Abstract

Background and Aims: Body composition predicts mortality in patients with cirrhosis. The impact of sex on this association is unknown. We investigated the impact of sex on this association in patients with cirrhosis assessed for liver transplantation., Methods: This single-centre retrospective cohort study included adults assessed for liver transplantation. Nutritional status was assessed using the Royal Free Hospital-Global Assessment (RFH-GA). Body composition at the third lumbar vertebrae was determined. Sarcopenia SMI was defined as Skeletal Muscle Index <50 cm 2 /m 2 in males and <39 cm 2 /m 2 in females. Sarcopenia PMI was defined as the sex-specific 25th percentile of the Psoas Muscle Index. Patients were assessed for the occurrence of liver transplantation and death. Analyses were stratified by sex., Results: The cohort comprised 628 patients, including 199 females and 429 males. Both groups were similar in terms of baseline liver disease severity by Model for End-stage Liver Disease (MELD) (p = .98) and nutritional status (p = .24). Sarcopenia SMI was present in 41% of males compared to 27% of females (p < .001). In the male cohort, when adjusted for age and MELD, sarcopenia PMI (aHR 1.74, 95% CI 1.08-2.80) and RFH-GA (aHR 1.40, 95% CI 1.03-1.90) remained independent predictors of mortality. Adipose tissue had no impact on outcomes in males. In female patients, adipose tissue (TATI or VATI depending on the multivariable model) was independently associated with mortality, whereas sarcopenia and malnutrition were not., Conclusions: This study demonstrates that male patients were susceptible to low muscle mass, whereas female patients were not. Future research in this patient population should minimize sex-related bias and present data for both groups separately., (© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results