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44 results on '"Cifuentes, Fredi"'

6. Chemical Fingerprinting, Aorta Endothelium Relaxation Effect, and Enzymatic Inhibition of Canelo (Drimys winteri J. R. Forst. & G. Forst, (D.C) A. Gray, Family Winteraceae) Fruits

Author

Barrientos, Ruth E., primary, Romero-Parra, Javier, additional, Cifuentes, Fredi, additional, Palacios, Javier, additional, Romero-Jola, Néstor Jaime, additional, Paredes, Adrián, additional, Vargas-Arana, Gabriel, additional, and Simirgiotis, Mario J., additional

Published
2023
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8. Antioxidant and potential neuroprotective activity of Heliotropium taltalense I.M. Johnst (Heliotropiaceae) extracts obtained by pressurized liquid extraction

Author

Barrientos, Ruth E., Álvarez-Rivera, Gerardo, Mohammadnezhad, Pouya, Cifuentes, Fredi, Palacios, Javier, Paredes, Adrián, Mendiola, J. A., Simirgiotis, Mario Juan, Ibáñez, Elena, Barrientos, Ruth E., Álvarez-Rivera, Gerardo, Mohammadnezhad, Pouya, Cifuentes, Fredi, Palacios, Javier, Paredes, Adrián, Mendiola, J. A., Simirgiotis, Mario Juan, and Ibáñez, Elena

Published
2023

9. UHPLC-MS Phenolic Fingerprinting, Aorta Endothelium Relaxation Effect, Antioxidant, and Enzyme Inhibition Activities of Azara dentata Ruiz & Pav Berries

Author

Ramos, Lucia Cuesta, primary, Palacios, Javier, additional, Barrientos, Ruth E., additional, Gómez, Jessica, additional, Castagnini, Juan Manuel, additional, Barba, Francisco J., additional, Tapia, Alejandro, additional, Paredes, Adrián, additional, Cifuentes, Fredi, additional, and Simirgiotis, Mario J., additional

Published
2023
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12. Supplementary Materials for Phenolic fingerprinting and bioactivity profiling of extracts and isolated compounds from Gypothamnium pinifolium Phil.

Author

Barrientos, Ruth E., Ibáñez, Elena, Puerta, Adrián, Padrón, José M., Paredes, Adrián, Cifuentes, Fredi, Romero-Parra, Javier, Palacios, Javier, Bórquez, Jorge, Simirgiotis, Mario Juan, Barrientos, Ruth E., Ibáñez, Elena, Puerta, Adrián, Padrón, José M., Paredes, Adrián, Cifuentes, Fredi, Romero-Parra, Javier, Palacios, Javier, Bórquez, Jorge, and Simirgiotis, Mario Juan

Published
2022

13. Metabolomic fingerprinting and biological activities of Gypothamnium pinifolium Phil. from Northern Chile

Author

Fondo Nacional de Desarrollo Científico y Tecnológico (Chile), Agencia Nacional de Investigación y Desarrollo (Chile), Universidad de Antofagasta, Barrientos, Ruth E., Álvarez-Rivera, Gerardo, Ibáñez, Elena, Mendiola, J. A., Paredes, Adrián, Cifuentes, Fredi, Palacios, Javier, Simirgiotis, Mario Juan, Fondo Nacional de Desarrollo Científico y Tecnológico (Chile), Agencia Nacional de Investigación y Desarrollo (Chile), Universidad de Antofagasta, Barrientos, Ruth E., Álvarez-Rivera, Gerardo, Ibáñez, Elena, Mendiola, J. A., Paredes, Adrián, Cifuentes, Fredi, Palacios, Javier, and Simirgiotis, Mario Juan

Published
2022

15. Metabolomic fingerprinting and biological activities of Gypothamnium pinifolium Phil. from Northern Chile

Author

Barrientos, Ruth E., Álvarez-Rivera, Gerardo, Ibáñez, Elena, Mendiola, J. A., Paredes, Adrián, Cifuentes, Fredi, Palacios, Javier, Simirgiotis, Mario Juan, Fondo Nacional de Desarrollo Científico y Tecnológico (Chile), Agencia Nacional de Investigación y Desarrollo (Chile), and Universidad de Antofagasta

Abstract

Resumen del trabajo presentado a la XXI Reunión Científica de la Sociedad Española de Cromatografía y Técnicas Afines (SECyTA), celebrada en Almería del 25 al 27 de octubre de 2022., Financial support was provided by FONDECYT 1180059 and 1220075 to M.J.S., FONDECYT 1200610 to J.P., the Network for Extreme Environments Research project to F.C. and A.P. (NEXER, Project ANT1756, Universidad de Antofagasta, Chile). R.B. received funding from ANID PFCHA/Beca Doctorado Nacional/2019-21191978.

Published
2022

20. Metabolomic Profiling of Mango (Mangifera indica Linn) Leaf Extract and Its Intestinal Protective Effect and Antioxidant Activity in Different Biological Models

Author

Ybañez-Julca, Roberto O., primary, Asunción-Alvarez, Daniel, additional, Quispe-Díaz, Ivan M., additional, Palacios, Javier, additional, Bórquez, Jorge, additional, Simirgiotis, Mario J., additional, Perveen, Shagufta, additional, Nwokocha, Chukwuemeka R., additional, Cifuentes, Fredi, additional, and Paredes, Adrián, additional

Published
2020
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27. Modulatory Effect of Guinep (Melicoccus bijugatus Jacq) Fruit Pulp Extract on Isoproterenol-Induced Myocardial Damage in Rats. Identification of Major Metabolites Using High Resolution UHPLC Q-Orbitrap Mass Spectrometry

Author

Nwokocha, Chukwuemeka, primary, Warren, Isheba, additional, Palacios, Javier, additional, Simirgiotis, Mario, additional, Nwokocha, Magdalene, additional, Harrison, Sharon, additional, Thompson, Rory, additional, Paredes, Adrian, additional, Bórquez, Jorge, additional, Lavado, Astrid, additional, and Cifuentes, Fredi, additional

Published
2019
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28. Ascorbic supplementation attenuates juglone induced metabolic derangement.

Author

Ayavire, Fernando, Miguel Fonseca, José, Salas, Felipe, Benites, Julio, Nwokocha, Chukwuemeka R., Paredes, Adrián, Cifuentes, Fredi, and Palacios, Javier

Subjects
CARBOHYDRATE metabolism, REACTIVE oxygen species, LIPID metabolism, OXIDATIVE stress, ANTINEOPLASTIC agents, VITAMIN C
Abstract

Copyright of Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas is the property of Universidad de Santiago de Chile and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021
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30. Vasodilator and hypotensive effects of pure compounds and hydroalcoholic extract of Xenophyllum poposum (Phil) V.A Funk (Compositae) on rats

Author

Cifuentes, Fredi, primary, Palacios, Javier, additional, Kuzmicic, Jovan, additional, Carvajal, Lorena, additional, Muñoz, Fernanda, additional, Quispe, Cristina, additional, Nwokocha, Chukwuemeka R., additional, Morales, Glauco, additional, Norambuena-Soto, Ignacio, additional, Chiong, Mario, additional, and Paredes, Adrián, additional

Published
2018
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31. Ascorbate Attenuates Oxidative Stress and Increased Blood Pressure Induced by 2-(4-Hydroxyphenyl) Amino-1,4-naphthoquinone in Rats

Author

Palacios, Javier, primary, Fonseca, José Miguel, additional, Ayavire, Fernando, additional, Salas, Felipe, additional, Ortiz, Mirko, additional, Sandoval, Juan Marcelo, additional, Benites, Julio, additional, Nwokocha, Chukwuemeka R., additional, Zavala, Ewaldo, additional, Paredes, Adrián, additional, Barría, Iván, additional, Vega, José Luis, additional, and Cifuentes, Fredi, additional

Published
2018
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33. Aqueous extract from leaf of Artocarpus altilis provides cardio-protection from isoproterenol induced myocardial damage in rats: Negative chronotropic and inotropic effects

Author

Nwokocha, Chukwuemeka, primary, Palacios, Javier, additional, Simirgiotis, Mario J., additional, Thomas, Jemesha, additional, Nwokocha, Magdalene, additional, Young, Lauriann, additional, Thompson, Rory, additional, Cifuentes, Fredi, additional, Paredes, Adrian, additional, and Delgoda, Rupika, additional

Published
2017
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34. Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta

Author

Universidad de Sevilla. Departamento de Fisiología, Palacios, Javier, Cifuentes, Fredi, Valderrama, Jaime A., Benites, Julio, Ríos, David, González, Constanza, Sobrevia Luarte, Luis, Universidad de Sevilla. Departamento de Fisiología, Palacios, Javier, Cifuentes, Fredi, Valderrama, Jaime A., Benites, Julio, Ríos, David, González, Constanza, and Sobrevia Luarte, Luis

Abstract

The vascular endothelium plays an essential role in the control of the blood flow. Pharmacological agents like quinone (menadione) at various doses modulate this process in a variety of ways. In this study, Q7, a 2-phenylamino-1,4-naphthoquinone derivative, significantly increased oxidative stress and induced vascular dysfunction at concentrations that were not cytotoxic to endothelial or vascular smooth muscle cells. Q7 reduced nitric oxide (NO) levels and endothelial vasodilation to acetylcholine in rat aorta. It also blunted the calcium release from intracellular stores by increasing the phenylephrine-induced vasoconstriction when CaCl2 was added to a calcium-free medium but did not affect the influx of calcium from extracellular space. Q7 increased the vasoconstriction to BaCl2 (10-3 M), an inward rectifying K+ channels blocker, and blocked the vasodilation to KCl (10-2 M) in aortic rings precontracted with BaCl2. This was recovered with sodium nitroprusside (10-8 M), a NO donor. In conclusion, Q7 induced vasoconstriction was through a modulation of cellular mechanisms involving calcium fluxes through K+ channels, and oxidative stress induced endothelium damage. These findings contribute to the characterization of new quinone derivatives with low cytotoxicity able to pharmacologically modulate vasodilation.

Published
2016

37. Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta

Author

Palacios, Javier, primary, Cifuentes, Fredi, additional, Valderrama, Jaime A., additional, Benites, Julio, additional, Ríos, David, additional, González, Constanza, additional, Chiong, Mario, additional, Cartes-Saavedra, Benjamín, additional, Lafourcade, Carlos, additional, Wyneken, Ursula, additional, González, Pamela, additional, Owen, Gareth I., additional, Pardo, Fabián, additional, Sobrevia, Luis, additional, and Buc Calderon, Pedro, additional

Published
2016
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43. Na+–K+–2Cl− cotransporter is implicated in gender differences in the response of the rat aorta to phenylephrine.

Author

Palacios, Javier, Espinoza, Francisco, Munita, Carolina, Cifuentes, Fredi, and Michea, Luis

Subjects
BUMETANIDE, BLOOD circulation, ENDOTHELIUM, OVARIECTOMY, RATS, ESTRADIOL
Abstract

Inhibition of the Na+–K+–2Cl− cotransporter (NKCC1) with bumetanide reduced contractile responses to phenylephrine (PE) in male rat aortas (129±4% of 60 mM KCl-induced contraction control vs 108±7% bumetanide; PE 10−5 M; P<0.01) but did not change equivalent responses in female rat aortas. Removal of the endothelium blunted the effect of NKCC1 inhibition on the response to PE (10−5 M) in males, whereas in denuded aorta from female rats, bumetanide reduced this response (162±5% control vs 146±3% bumetanide; P<0.05).NKCC1 basal activity did not show gender differences in intact aortic rings, but in the presence of PE, bumetanide-sensitive 86Rb+/K+ uptake increased more in male than female aortas (179±8 in males vs 158±5 nmol 86Rb+/K+ min−1 (g aorta)−1 in females; P<0.05). PE did not stimulate NKCC1 activity in denuded aorta from male rats. However, in female rats, PE increased NKCC1 activity similarly in both denuded (169±11 nmol 86Rb+/K+ min−1 (g aorta)−1) and intact aortas.Ovariectomy increased the bumetanide-sensitive 86Rb+/K+ uptake increase elicited by PE (223±17 nmol 86Rb+/K+ min−1 (g aorta)−1) and hormone replacement with 17β-estradiol prevented this effect (159±29 nmol 86Rb+/K+ min−1 (g aorta)−1).Na+,K+-ATPase basal activity, measured as ouabain-sensitive 86Rb+/K+ uptake, was similar in male and female rats, but the effect of PE was significantly less in intact male aortas (232±16 in males vs 296±25 nmol 86Rb+/K+ min−1 (g aorta)−1 in females; P<0.05).Our results suggest that PE induced activation of NKCC1 and Na+,K+-ATPase in the rat aorta in a gender-dependent way.British Journal of Pharmacology (2006) 148, 964–972. doi:10.1038/sj.bjp.0706818; published online 26 June 2006 [ABSTRACT FROM AUTHOR]

Published
2006
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44. Calcium signaling in endothelial and vascular smooth muscle cells: sex differences and the influence of estrogens and androgens.

Author

Asunción-Alvarez D, Palacios J, Ybañez-Julca RO, Rodriguez-Silva CN, Nwokocha C, Cifuentes F, and Greensmith DJ

Subjects
Female, Male, Humans, Calcium metabolism, Androgens metabolism, Estrogens metabolism, Sex Characteristics, Endothelial Cells metabolism, Caffeine pharmacology, Myocytes, Smooth Muscle metabolism, Calcium Signaling physiology, Muscle, Smooth, Vascular metabolism
Abstract

Calcium signaling in vascular endothelial cells (ECs) and smooth muscle cells (VSMCs) is essential for the regulation of vascular tone. However, the changes to intracellular Ca 2+ concentrations are often influenced by sex differences. Furthermore, a large body of evidence shows that sex hormone imbalance leads to dysregulation of Ca 2+ signaling and this is a key factor in the pathogenesis of cardiovascular diseases. In this review, the effects of estrogens and androgens on vascular calcium-handling proteins are discussed, with emphasis on the associated genomic or nongenomic molecular mechanisms. The experimental models from which data were collected were also considered. The review highlights 1 ) in female ECs, transient receptor potential vanilloid 4 (TRPV4) and mitochondrial Ca 2+ uniporter (MCU) enhance Ca 2+ -dependent nitric oxide (NO) generation. In males, only transient receptor potential canonical 3 (TRPC3) plays a fundamental role in this effect. 2 ) Female VSMCs have lower cytosolic Ca 2+ levels than males due to differences in the activity and expression of stromal interaction molecule 1 (STIM1), calcium release-activated calcium modulator 1 (Orai1), calcium voltage-gated channel subunit-α 1C (Ca V 1.2), Na + -K + -2Cl - symporter (NKCC1), and the Na + /K + -ATPase. 3 ) When compared with androgens, the influence of estrogens on Ca 2+ homeostasis, vascular tone, and incidence of vascular disease is better documented. 4 ) Many studies use supraphysiological concentrations of sex hormones, which may limit the physiological relevance of outcomes. 5 ) Sex-dependent differences in Ca 2+ signaling mean both sexes ought to be included in experimental design.

Published
2024
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