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1. The discovery and structural basis of two distinct state-dependent inhibitors of BamA

2. Targeted degradation via direct 26S proteasome recruitment

3. Structural architecture of the human NALCN channelosome

8. Structural basis of α-scorpion toxin action on Na v channels

9. Structure of the human sodium leak channel NALCN

10. Protein domain mapping by internal labeling and single particle electron microscopy

13. A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities

14. Molecular architecture of human polycomb repressive complex 2.

19. Semiautomated Small-Scale Purification Method for High-Throughput Expression Analysis of Recombinant Proteins

22. Cryo-EM reveals an unprecedented binding site for NaV1.7 inhibitors enabling rational design of potent hybrid inhibitors

23. Author response: Cryo-EM reveals an unprecedented binding site for NaV1.7 inhibitors enabling rational design of potent hybrid inhibitors

26. Targeted degradation via direct 26S proteasome recruitment

27. CryoEM reveals unprecedented binding site for NaV1.7 inhibitors enabling rational design of potent hybrid inhibitors

28. Overcoming Preclinical Safety Obstacles to Discover (S)-N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor

29. List of Contributors

32. Structural basis for HCMV Pentamer receptor recognition and antibody neutralization

33. Structure and function of the human NALCN-UNC79-UNC80-FAM155A-CaM complex

36. Structural architecture of the human NALCN channelosome

40. Taking away PAIN: enabling new structures of the Nav1.7 sodium channel by cryo-EM

43. Kinetochore Microtubule Dynamics and Attachment Stability Are Regulated by Hec1

44. A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment

46. Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab

50. Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel.

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