Search

Your search keyword '"Ciccone M"' showing total 413 results
Start Over Author "Ciccone M"
413 results on '"Ciccone M"'

1. Cardiovascular risk evaluation and prevalence of silent myocardial ischemia in subjects with asymptomatic carotid artery disease

Author

Ciccone M, Niccoli AA, Scicchitano P, Gesualdo M, Notaristefano A, Chieppa D, Carbonara S, Ricci G, Sassara, Altini C, Quistelli Giovanni, Lepera ME, Favale S, and Rubini G

Subjects
asymptomatic carotid artery disease, silent myocardial ischemia, myocardial stress scintigraphy., Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Marco Matteo Ciccone1, Artor Niccoli-Asabella2, Pietro Scicchitano1, Michele Gesualdo1, Antonio Notaristefano2, Domenico Chieppa1, Santa Carbonara1, Gabriella Ricci1, Marco Sassara1, Corinna Altini2, Giovanni Quistelli1, Mario Erminio Lepera1, Stefano Favale1, Giuseppe Rubini21Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), 2Nuclear Medicine Unit, Department of Internal Medicine and of Public Medicine, University of Bari, Bari, ItalyIntroduction: Silent ischemia is an asymptomatic form of myocardial ischemia, not associated with angina or anginal equivalent symptoms, which can be demonstrated by changes in ECG, left ventricular function, myocardial perfusion, and metabolism. The aim of this study was to evaluate the prevalence of silent myocardial ischemia in a group of patients with asymptomatic carotid stenosis.Methods: A total of 37 patients with asymptomatic carotid plaques, without chest pain or dyspnea, was investigated. These patients were studied for age, sex, hypertension, diabetes, dyslipidemia, smoking, and family history of cardiac disease, and underwent technetium-99 m sestamibi myocardial stress-rest scintigraphy and echo-color Doppler examination of carotid arteries.Results: A statistically significant relationship (P = 0.023) was shown between positive responders and negative responders to scintigraphy test when both were tested for degree of stenosis. This relationship is surprising in view of the small number of patients in our sample. Individuals who had a positive scintigraphy test had a mean stenosis degree of 35% ± 7% compared with a mean of 44% ± 13% for those with a negative test. Specificity of our detection was 81%, with positive and negative predictive values of 60% and 63%, respectively.Conclusion: The present study confirms that carotid atherosclerosis is associated with coronary atherosclerosis and highlights the importance of screening for ischemic heart disease in patients with asymptomatic carotid plaques, considering eventually plaque morphology (symmetry, composition, eccentricity or concentricity of the plaque, etc) for patient stratification.Keywords: asymptomatic carotid artery disease, silent myocardial ischemia, myocardial stress scintigraphy

Published
2011

2. ECG/echo indexes in the diagnostic approach to amyloid cardiomyopathy: A head-to-head comparison from the AC-TIVE study

Author

Pagura, L, Porcari, A, Cameli, M, Biagini, E, Canepa, M, Crotti, L, Imazio, M, Forleo, C, Pavasini, R, Limongelli, G, Perlini, S, Metra, M, Boriani, G, Emdin, M, Sinagra, G, Merlo, M, Longo, F, Rossi, M, Varrà, G, Saro, R, Dore, F, Girardi, F, Vergaro, G, Musumeci, B, Autore, C, Cappelli, F, Perfetto, F, Olivotto, I, Favale, S, Carella, M, Guaricci, A, Ciccone, M, Di Bella, G, Tomasoni, D, Rella, V, Branzi, G, Badano, L, Parati, G, Palmiero, G, Caiazza, M, Caponetti, A, Saturi, G, Labate, M, Andreis, A, Paneva, E, De Ferrari, G, Di Ienno, L, De Carli, G, Giacomin, E, Arzilli, C, Pagura L., Porcari A., Cameli M., Biagini E., Canepa M., Crotti L., Imazio M., Forleo C., Pavasini R., Limongelli G., Perlini S., Metra M., Boriani G., Emdin M., Sinagra G., Merlo M., Longo F., Rossi M., Varrà G. G., Saro R., Dore F., Girardi F., Vergaro G., Musumeci B., Autore C., Cappelli F., Perfetto F., Olivotto I., Favale S., Carella M. C., Guaricci A. I., Ciccone M. M., Di Bella G., Tomasoni D., Rella V., Branzi G., Badano L., Parati G., Palmiero G., Caiazza M., Caponetti A. G., Saturi G., Labate M. E., Andreis A., Paneva E., De Ferrari G. M., Di Ienno L., De Carli G., Giacomin E., Arzilli C., Pagura, L, Porcari, A, Cameli, M, Biagini, E, Canepa, M, Crotti, L, Imazio, M, Forleo, C, Pavasini, R, Limongelli, G, Perlini, S, Metra, M, Boriani, G, Emdin, M, Sinagra, G, Merlo, M, Longo, F, Rossi, M, Varrà, G, Saro, R, Dore, F, Girardi, F, Vergaro, G, Musumeci, B, Autore, C, Cappelli, F, Perfetto, F, Olivotto, I, Favale, S, Carella, M, Guaricci, A, Ciccone, M, Di Bella, G, Tomasoni, D, Rella, V, Branzi, G, Badano, L, Parati, G, Palmiero, G, Caiazza, M, Caponetti, A, Saturi, G, Labate, M, Andreis, A, Paneva, E, De Ferrari, G, Di Ienno, L, De Carli, G, Giacomin, E, Arzilli, C, Pagura L., Porcari A., Cameli M., Biagini E., Canepa M., Crotti L., Imazio M., Forleo C., Pavasini R., Limongelli G., Perlini S., Metra M., Boriani G., Emdin M., Sinagra G., Merlo M., Longo F., Rossi M., Varrà G. G., Saro R., Dore F., Girardi F., Vergaro G., Musumeci B., Autore C., Cappelli F., Perfetto F., Olivotto I., Favale S., Carella M. C., Guaricci A. I., Ciccone M. M., Di Bella G., Tomasoni D., Rella V., Branzi G., Badano L., Parati G., Palmiero G., Caiazza M., Caponetti A. G., Saturi G., Labate M. E., Andreis A., Paneva E., De Ferrari G. M., Di Ienno L., De Carli G., Giacomin E., and Arzilli C.

Abstract

Background and aims: The discordance between QRS voltages on electrocardiogram (ECG) and left ventricle (LV) wall thickness (LVWT) on echocardiogram (echo) is a recognized red flag (RF) of amyloid cardiomyopathy (AC) and can be measured by specific indexes. No head-to-head comparison of different ECG/echo indexes among subjects with echocardiographic suspicion of AC has yet been undertaken. The study aimed at evaluating the performance and the incremental diagnostic value of different ECG/echo indexes in this subset of patients. Methods: Electrocardiograms of subjects with LV hypertrophy, preserved ejection fraction and ≥ 1 echocardiographic RF of AC participating in the AC-TIVE study, an Italian prospective multicenter study, were independently analyzed by two cardiologists. Low QRS voltages and 8 different ECG/echo indexes were evaluated. Cohort specific cut-offs were computed. Results: Among 170 patients, 55 (32 %) were diagnosed with AC. Combination of low QRS voltages with interventricular septum ≥ 1,6 cm was the most specific (specificity 100 %, positive predictive value 100 %) ECG/echo index, while the ratio between the sum of all QRS voltages and LVWT <7,8 was the most sensitive and accurate (sensitivity 94 %, negative predictive value 97 %, accuracy 82 %). When the latter index was added to a model using easily-accessible clinical variables, the diagnostic accuracy for AC greatly increased (AUC from 0,84 to 0,95; p = 0,007). Conclusions: Among patients with non-dilated hypertrophic ventricles with normal ejection fraction and echocardiographic RF of AC, easily-measurable ECG/echo indexes, mainly when added to few clinical variables, can help the physician orient second level investigations. External validation of the results is warranted.

Published
2024

3. Come superare le barriere all'implementazione delle strategie di prevenzione e cura della malattia cardiovascolare aterosclerotica mediante terapia ipolipemizzante

Author

Arca, M, Averna, M, Borghi, C, Lettino, M, Filardi, P, Alberti, A, Bilato, C, Calabrò, P, Carubbi, F, Ciccone, M, Cipollone, F, Citroni, N, De Luca, L, Giaccari, A, Iannuzzo, G, Maloberti, A, Marcucci, R, Spinazzola, P, Pirro, M, Pisciotta, L, Sarullo, F, Sciacqua, A, Suppressa, P, Varbella, F, Werba, J, Zambon, A, Arca M., Averna M., Borghi C., Lettino M., Filardi P. P., Alberti A., Bilato C., Calabrò P., Carubbi F., Ciccone M. M., Cipollone F., Citroni N., De Luca L., Giaccari A., Iannuzzo G., Maloberti A., Marcucci R., Spinazzola P. P., Pirro M., Pisciotta L., Sarullo F., Sciacqua A., Suppressa P., Varbella F., Werba J. P., Zambon A., Arca, M, Averna, M, Borghi, C, Lettino, M, Filardi, P, Alberti, A, Bilato, C, Calabrò, P, Carubbi, F, Ciccone, M, Cipollone, F, Citroni, N, De Luca, L, Giaccari, A, Iannuzzo, G, Maloberti, A, Marcucci, R, Spinazzola, P, Pirro, M, Pisciotta, L, Sarullo, F, Sciacqua, A, Suppressa, P, Varbella, F, Werba, J, Zambon, A, Arca M., Averna M., Borghi C., Lettino M., Filardi P. P., Alberti A., Bilato C., Calabrò P., Carubbi F., Ciccone M. M., Cipollone F., Citroni N., De Luca L., Giaccari A., Iannuzzo G., Maloberti A., Marcucci R., Spinazzola P. P., Pirro M., Pisciotta L., Sarullo F., Sciacqua A., Suppressa P., Varbella F., Werba J. P., and Zambon A.

Abstract

Atherosclerotic cardiovascular diseases remain the main cause of mortality worldwide, due to a poor control of modifiable risk factors for atherosclerosis. High levels of low-density lipoprotein cholesterol represent the most relevant actor in the development of atherosclerotic cardiovascular diseases, as well as the main target promuovoof prevention strategies. Although lipid-lowering treatments were shown to be effective for cardiovascular prevention, several barriers (e.g. clinician reluctance to prescribe an intensive treatment, poor adherence of patients to therapy, high pharmacotherapy burden of high-risk patients and the fear for adverse events potentially associated with statins) still prevent therapy optimization. Such issues will be addressed in this review article, taking into account possible strategies for their solution, through an integrated approach including both management interventions and a larger use of the available pharmacologic options.

Published
2023

4. Efficacy, safety, adherence and persistence of PCSK9 inhibitors in clinical practice: A single country, multicenter, observational study (AT-TARGET-IT)

Author

Gargiulo, P, Basile, C, Cesaro, A, Marzano, F, Buonocore, D, Asile, G, Abbate, V, Vicidomini, F, Paolillo, S, Spaccarotella, C, Catalano, A, Spirito, G, Merlini, P, Maloberti, A, Iannuzzo, G, Ciccone, M, Zito, A, Paloscia, L, D'Alleva, A, Varbella, F, Corleto, A, Brunetti, N, Corbo, M, Calabro, P, Indolfi, C, Perrone-Filardi, P, Gargiulo P., Basile C., Cesaro A., Marzano F., Buonocore D., Asile G., Abbate V., Vicidomini F., Paolillo S., Spaccarotella C. A. M., Catalano A., Spirito G., Merlini P. A., Maloberti A., Iannuzzo G., Ciccone M. M., Zito A. P., Paloscia L., D'Alleva A., Varbella F., Corleto A., Brunetti N. D., Corbo M. D., Calabro P., Indolfi C., Perrone-Filardi P., Gargiulo, P, Basile, C, Cesaro, A, Marzano, F, Buonocore, D, Asile, G, Abbate, V, Vicidomini, F, Paolillo, S, Spaccarotella, C, Catalano, A, Spirito, G, Merlini, P, Maloberti, A, Iannuzzo, G, Ciccone, M, Zito, A, Paloscia, L, D'Alleva, A, Varbella, F, Corleto, A, Brunetti, N, Corbo, M, Calabro, P, Indolfi, C, Perrone-Filardi, P, Gargiulo P., Basile C., Cesaro A., Marzano F., Buonocore D., Asile G., Abbate V., Vicidomini F., Paolillo S., Spaccarotella C. A. M., Catalano A., Spirito G., Merlini P. A., Maloberti A., Iannuzzo G., Ciccone M. M., Zito A. P., Paloscia L., D'Alleva A., Varbella F., Corleto A., Brunetti N. D., Corbo M. D., Calabro P., Indolfi C., and Perrone-Filardi P.

Abstract

Background and aims: Proprotein Convertase Subtilisin/Kexin type 9 inhibitors (PCSK9i) are recommended in patients at high and very-high cardiovascular (CV) risk, with documented atherosclerotic CV disease (ASCVD), and for very-high risk patients with familial hypercholesterolaemia not achieving LDL-cholesterol (LDL-C) goal while receiving maximally tolerated dose of lipid-lowering therapy (LLT). However, single country real-life data, reporting the use of PCSK9i in clinical practice, are limited. Therefore, we designed AT-TARGET-IT, an Italian, multicenter, observational registry on the use of PCSK9i in clinical practice. Methods: All data were recorded at the time of the first prescription and at the latest observation preceding inclusion in the study. Results: 798 patients were enrolled. The median reduction in LDL-C levels was 64.9%. After stratification for CV risk, 63.8% achieved LDL-C target; of them, 83.3% took LLTs at PCSK9i initiation and 16.7% did not. 760 patients (95.2%) showed high adherence to therapy, 13 (1.6%) partial adherence, and 25 (3.1%) poor adherence. At 6 months, 99.7% of patients enrolled in the study remained on therapy; there were 519 and 423 patients in the study with a follow-up of at least 12 and 18 months, respectively. Persistence in these groups was 98.1% and 97.5%, respectively. Overall, 3.5% of patients discontinued therapy. No differences in efficacy, adherence, and persistence were found between alirocumab and evolocumab. Conclusions: PCSK9i are safe and effective in clinical practice, leading to very high adherence and persistence to therapy, and achievement of recommended LDL-C target in most patients, especially when used as combination therapy.

Published
2023

6. Efficacy, safety, adherence and persistence of PCSK9 inhibitors in clinical practice: a single country, multicenter, observational study (AT-TARGET-IT)

Author

Gargiulo, P, primary, Basile, C, additional, Calabro', P, additional, Catalano, A, additional, Merlini, P A, additional, Iannuzzo, G, additional, Ciccone, M M, additional, Paloscia, L, additional, Varbella, F, additional, Brunetti, N D, additional, Paolillo, S, additional, Marzano, F, additional, Indolfi, C, additional, and Perrone-Filardi, P, additional

Published
2023
Full Text
View/download PDF

7. Efficacy and safety of inclisiran in real world practice: insights from the Cholinet registry

Author

Basile, C, primary, Gargiulo, P, additional, Merlini, P A, additional, Brunetti, N D, additional, Musumeci, G, additional, Casu, G, additional, Galasso, G, additional, Varbella, F, additional, Calabro', P, additional, Ciccone, M M, additional, Calo', L, additional, Bilato, C, additional, Paolillo, S, additional, Indolfi, C, additional, and Perrone-Filardi, P, additional

Published
2023
Full Text
View/download PDF

8. Left Ventricular Global Longitudinal Strain (LV GLS) assessed by Echocardiography predicts myocardial fibrosis and iron overload in transfusion dependent beta-thalassemia patients

Author

Guaricci, A I, primary, Basile, P, additional, Monitillo, F, additional, Dadamo, M L, additional, Giordano, P, additional, Santoro, D, additional, Di Gennaro, D, additional, Mushtaq, S, additional, Baggiano, A, additional, Fazzari, F, additional, Fusini, L, additional, Forleo, C, additional, Vitucci, A, additional, Pontone, G, additional, and Ciccone, M M, additional

Published
2023
Full Text
View/download PDF

10. OC 07.3 In vitro and ex vivo Rescue of a Nonsense Mutation (F5 p.Arg1161Ter) Responsible for Severe Coagulation Factor V Deficiency

Author

Todaro, A., primary, Radu, C., additional, Ciccone, M., additional, Toffanin, S., additional, Serino, M., additional, Campello, E., additional, Bulato, C., additional, Lunghi, B., additional, Gemmati, D., additional, Cuneo, A., additional, Hackeng, T., additional, Simioni, P., additional, Bernardi, F., additional, and Castoldi, E., additional

Published
2023
Full Text
View/download PDF

19. PCSK9 inhibitors: effectiveness of treatment and changes in background lipid-lowering therapy in a real world Italian population. The AT-TARGET-IT study

Author

Perrone-Filardi, P, primary, Basile, C, additional, Asile, G, additional, Abbate, C, additional, Catalano, A, additional, Merlini, P A, additional, Calabro', P, additional, Iannuzzo, G, additional, Ciccone, M M, additional, Paloscia, L, additional, Varbella, F, additional, Brunetti, N D, additional, Indolfi, C, additional, Paolillo, S, additional, and Gargiulo, P, additional

Published
2022
Full Text
View/download PDF

20. Italian Society of Cardiology (SIC) Expert consensus document: Post-acute cardiovascular sequelae of SARS-CoV-2 infection

Author

Indolfi C., Barilla F., Basso C., Ciccone M. M., Curcio A., Gargiulo P., Nodari S., Mercuro G., Mancone M., Muscoli S., Pedrinelli R., Porcari A., Spaccarotella C., Romeo F., Sinagra G., Filardi P. P., Indolfi, C., Barilla, F., Basso, C., Ciccone, M. M., Curcio, A., Gargiulo, P., Nodari, S., Mercuro, G., Mancone, M., Muscoli, S., Pedrinelli, R., Porcari, A., Spaccarotella, C., Romeo, F., Sinagra, G., and Filardi, P. P.

Abstract

Although the clinical course of COVID-19 in its acute phase is now delineated, less known is its late phase characterized by a heterogeneous series of sequelae affecting various organs and systems, including the cardiovascular system, which continue after the acute episode or arise after their resolution. This syndrome, now referred with the new acronym "PASC" (post-acute sequelae of SARS-CoV-2 infection) has been formally recognized by various scientific societies and international organizations that have proposed various definitions. The World Health Organization defines PASC, distinguishing it from "ongoing symptomatic COVID-19", as a condition that arises few weeks after infection, persists at least 8 weeks, and cannot be explained by alternative diagnoses.There are multiple mechanisms responsible for PASC: inflammation, immune activation, viral persistence, activation of latent viruses, endothelial dysfunction, impaired response to exercise, and profound cardiac deconditioning following viral infection. The key symptoms of PASC are palpitations, effort dyspnea, chest pain, exercise intolerance, and postural orthostatic tachycardia syndrome.For PASC treatment, it may be useful to take salt and fluid loading, to reduce symptoms such as tachycardia, palpitations, and/or orthostatic hypotension, or in some subjects the use of drugs such as beta-blockers, non-dihydropyridine calcium channel blockers, ivabradine, and fludrocortisone.Finally, in PASC a gradual resumption of physical activity is recommended, starting with recumbent or semi-recumbent exercise, such as cycling, swimming, or rowing, and then moving on to exercise in an upright position such as running when the ability to stand improves without dyspnea appearance. Exercise duration should also be short initially (5 to 10 min per day), with gradual increases as functional capacity improves.

Published
2022

21. [Italian Society of Cardiology-Italian Society of Nephrology Consensus document: The cardio-renal interaction in the prevention and treatment of cardiovascular diseases - Part II: From preventive strategies to treatment of patients with cardio-renal damage]

Author

Indolfi C., Barilla F., Basile C., Basso C., Cantaluppi V., Capasso G., Ciccone M. M., Contessi S., Curcio A., De Nicola L., Esposito C., Imeraj A., Lecis D., Mancone M., Marengo M., Mercuro G., Merlo M., Metra M., Adamo M., Muscoli S., Nodari S., Pagura L., Paoletti E., Paolillo S., Pedrinelli R., Filardi P. P., Pertosa G. B., Pezzato A., Pontremoli R., Romeo F., Ruggenenti P., Ronco C., Santoro A., Sinagra G., Spaccarotella C., Zippo D., Zoccali C., Messa P., Indolfi, C., Barilla, F., Basile, C., Basso, C., Cantaluppi, V., Capasso, G., Ciccone, M. M., Contessi, S., Curcio, A., De Nicola, L., Esposito, C., Imeraj, A., Lecis, D., Mancone, M., Marengo, M., Mercuro, G., Merlo, M., Metra, M., Adamo, M., Muscoli, S., Nodari, S., Pagura, L., Paoletti, E., Paolillo, S., Pedrinelli, R., Filardi, P. P., Pertosa, G. B., Pezzato, A., Pontremoli, R., Romeo, F., Ruggenenti, P., Ronco, C., Santoro, A., Sinagra, G., Spaccarotella, C., Zippo, D., Zoccali, C., and Messa, P.

Subjects
Diabetes mellitu, Consensus, Cardiology, Contrast Media, Cardiovascular disease, Atrial fibrillation, Cardiovascular Diseases, Nephrology, Acute kidney disease, Chronic kidney disease, Humans, Renal Insufficiency, Chronic, Renal Insufficiency, Hyperkaliemia, Chronic
Abstract

Chronic kidney disease and cardiovascular disease are strictly connected each other with a bidirectional interaction. Thus, the prevention of cardio-renal damage, as its appropriate treatment, are essential steps for a correct management of long-term patients' prognosis. Several preventive and therapeutic strategies, pharmacological and not, are now available for cardio-renal damage prevention and treatment, and for the management of its complications. The second part of this consensus document focuses on the management and treatment of cardio-renal damage, directing the attention on the correct use of drugs that may slow renal disease progression, on the application of preventive strategies in case of invasive cardiac procedures with the use of contrast agents, and on the accurate use of cardiological drugs in patients with chronic kidney disease.

Published
2022

22. Continuous flow left ventricular assist devices do not worsen endothelial function in subjects with chronic heart failure: a pilot study

Author

Cortese, F, Ciccone, M, Gesualdo, M, Iacoviello, M, Frigerio, M, Cipriani, M, Giannattasio, C, Maloberti, A, Giordano, P, Cortese F., Ciccone M. M., Gesualdo M., Iacoviello M., Frigerio M., Cipriani M., Giannattasio C., Maloberti A., Giordano P., Cortese, F, Ciccone, M, Gesualdo, M, Iacoviello, M, Frigerio, M, Cipriani, M, Giannattasio, C, Maloberti, A, Giordano, P, Cortese F., Ciccone M. M., Gesualdo M., Iacoviello M., Frigerio M., Cipriani M., Giannattasio C., Maloberti A., and Giordano P.

Abstract

Aims: To evaluate endothelial function in subjects with left ventricular assist devices (LVADs), comparing them with subjects with chronic heart failure with reduced ejection fraction on the list for heart transplant (HT) and with HT patients with a normal systolic cardiac function to identify any differences. Methods: We enrolled 28 subjects with LVAD, 55 subjects with HT, and 42 subjects with heart failure on the transplant list. The subjects underwent a general physical examination, assessment of laboratory blood parameters, and assessment of endothelial function through flow-mediated dilation (FMD) of brachial artery. Results: The three groups were homogeneous as regards age, gender, smoke abuse, C-reactive protein (CRP) and FMD parameters (P = ns). In LVAD group percentage of FMD change showed an inverse correlation with CRP (rho: −0.5, P: 0.003), a well-known marker of inflammation and tissue damage. Conclusions: Continuous flow related to LVAD seems to not worsen endothelial function. Endothelial function was not affected by cardiovascular risk factors (hypertension, hypercholesterolaemia, diabetes, obesity, and tobacco habit), by the functional status expressed by New York Heart Association class, by the left ventricular systolic function and by the presence or absence of ischaemic heart disease in all the populations analysed. CRP was the only factor able to influence percentage of FMD change in patient with LVAD, reinforcing the hypothesis that inflammation is the main determinant of endothelial function.

Published
2021

23. Clinical management of older, frail patients with atrial fibrillation. The proposal of a multidisciplinary working group

Author

Marchionni, N, Fumagalli, S, Bo, M, Boccanelli, A, Boriani, G, Rubboli, A, Violi, F, Di Pasquale, G, Beer, B, Colonna, P, Manetti, L, Pilleri, A, Purificato, F, Ruotolo, G, Sciacqua, A, Taberini, L, Turcato, E, Bozzato, S, Catanzariti, D, Felici, M, Florio, C, Fontana, F, Giomi, A, Masala, R, Mascia, G, Nassiacos, D, Nesti, M, Okoye, C, Pestelli, G, Bassi, V, Curci, S, D'Avino, M, Doimo, S, Faustino, M, Gemmiti, M, Pignatelli, P, Sarli, G, Stefanoni, P, Ciccone, M, Diemberger, I, Gragnano, F, Serafini, F, Marchionni N., Fumagalli S., Bo M., Boccanelli A., Boriani G., Rubboli A., Violi F., Di Pasquale G., Beer B., Colonna P., Manetti L. L., Pilleri A., Purificato F., Ruotolo G., Sciacqua A., Taberini L., Turcato E., Bozzato S., Catanzariti D., Felici M., Florio C., Fontana F., Giomi A., Masala R., Mascia G., Nassiacos D., Nesti M., Okoye C., Pestelli G., Bassi V., Curci S., D'Avino M., Doimo S., Faustino M., Gemmiti M. P., Pignatelli P., Sarli G., Stefanoni P., Ciccone M., Diemberger I., Gragnano F., Serafini F., Marchionni, N, Fumagalli, S, Bo, M, Boccanelli, A, Boriani, G, Rubboli, A, Violi, F, Di Pasquale, G, Beer, B, Colonna, P, Manetti, L, Pilleri, A, Purificato, F, Ruotolo, G, Sciacqua, A, Taberini, L, Turcato, E, Bozzato, S, Catanzariti, D, Felici, M, Florio, C, Fontana, F, Giomi, A, Masala, R, Mascia, G, Nassiacos, D, Nesti, M, Okoye, C, Pestelli, G, Bassi, V, Curci, S, D'Avino, M, Doimo, S, Faustino, M, Gemmiti, M, Pignatelli, P, Sarli, G, Stefanoni, P, Ciccone, M, Diemberger, I, Gragnano, F, Serafini, F, Marchionni N., Fumagalli S., Bo M., Boccanelli A., Boriani G., Rubboli A., Violi F., Di Pasquale G., Beer B., Colonna P., Manetti L. L., Pilleri A., Purificato F., Ruotolo G., Sciacqua A., Taberini L., Turcato E., Bozzato S., Catanzariti D., Felici M., Florio C., Fontana F., Giomi A., Masala R., Mascia G., Nassiacos D., Nesti M., Okoye C., Pestelli G., Bassi V., Curci S., D'Avino M., Doimo S., Faustino M., Gemmiti M. P., Pignatelli P., Sarli G., Stefanoni P., Ciccone M., Diemberger I., Gragnano F., and Serafini F.

Abstract

Atrial fibrillation (AF) is the most common arrhythmia in elderly people. Older patients with AF have several comorbidities and should be treated with complex therapeutic schemes. Arrhythmia complications are also common at an advanced age. Accordingly, AF can be considered a marker of frailty. Few indications can be found concerning the management of frail older subjects in current guidelines. The Frailty in Atrial Fibrillation Survey Study (FAST) was designed to overcome the gap of knowledge about this extremely vulnerable subset of patients. A multidisciplinary team composed by cardiologists, geriatricians and internists participated in the project. In a first phase, a survey was conducted aiming at clarifying specialty-related differences in definition and oral anticoagulant therapy (OAT) management of frail individuals. In the second phase, specific chapters were prepared about AF and frailty epidemiology, the network for the management of the arrhythmia, the diagnostic strategies for AF (including a minimum data set of tools derived from the geriatric multidimensional assessment), OAT and the choice between a rate or a rhythm control strategy. For each chapter, up-to-date evidence and current guideline recommendations were presented and discussed among the 47 Italian centers participating in the project. In the last phase of FAST, the results of the survey and the final draft of the chapters were merged into the present document. A lack of homogeneity in frailty definition existed. The integration among cardiologists, geriatricians and internists can represent the most effective tool to get through these differences improving the management of frail older patients.

Published
2021

25. Comorbidities in chronic heart failure: An update from Italian Society of Cardiology (SIC) Working Group on Heart Failure

Author

Correale, M, Paolillo, S, Mercurio, V, Limongelli, G, Barilla, F, Ruocco, G, Palazzuoli, A, Scrutinio, D, Lagioia, R, Lombardi, C, Lupi, L, Magri, D, Masarone, D, Pacileo, G, Scicchitano, P, Matteo Ciccone, M, Parati, G, Tocchetti, C, Nodari, S, Correale M., Paolillo S., Mercurio V., Limongelli G., Barilla F., Ruocco G., Palazzuoli A., Scrutinio D., Lagioia R., Lombardi C., Lupi L., Magri D., Masarone D., Pacileo G., Scicchitano P., Matteo Ciccone M., Parati G., Tocchetti C. G., Nodari S., Correale, M, Paolillo, S, Mercurio, V, Limongelli, G, Barilla, F, Ruocco, G, Palazzuoli, A, Scrutinio, D, Lagioia, R, Lombardi, C, Lupi, L, Magri, D, Masarone, D, Pacileo, G, Scicchitano, P, Matteo Ciccone, M, Parati, G, Tocchetti, C, Nodari, S, Correale M., Paolillo S., Mercurio V., Limongelli G., Barilla F., Ruocco G., Palazzuoli A., Scrutinio D., Lagioia R., Lombardi C., Lupi L., Magri D., Masarone D., Pacileo G., Scicchitano P., Matteo Ciccone M., Parati G., Tocchetti C. G., and Nodari S.

Abstract

The increasing number of patients with heart failure HF and comorbidities is due to aging population and increase of life expectancy of patients with cardiovascular disease. Encouraging results derived by recent trials may suggest some comorbidities as new targets for new drugs, highlighting the need for a better understanding of the comorbidities’ effects in HF patients and the need of a multidisciplinary approach for the management of chronic HF with comorbidities. We report a brief review about main cardiovascular and non-cardiovascular comorbidities in HF patients in order to update physicians and researchers engaged in the HF research or in “fight against heart failure.”

Published
2020

26. Reduction of hospitalizations for myocardial infarction in Italy in the COVID-19 era

Author

De Rosa, S, Spaccarotella, C, Basso, C, Calabro, M, Curcio, A, Filardi, P, Mancone, M, Mercuro, G, Muscoli, S, Nodari, S, Pedrinelli, R, Sinagra, G, Indolfi, C, Angelini, F, Barilla, F, Bartorelli, A, Benedetto, F, Bernabo, P, Bolognese, L, Briani, M, Cacciavillani, L, Calabrese, A, Calabro, P, Caliendo, L, Calo, L, Casella, G, Casu, G, Cavallini, C, Ciampi, Q, Ciccone, M, Comito, M, Corrada, E, Crea, F, D'Andrea, A, D'Urbano, M, De Caterina, R, De Ferrari, G, De Ponti, R, Della Mattia, A, DI Mario, C, Donnazzan, L, Esposito, G, Fedele, F, Ferraro, A, Galasso, G, Galie, N, Gnecchi, M, Golino, P, Golia, B, Guarini, P, Leonardi, S, Locuratolo, N, Luzza, F, Manganiello, V, Francesca Marchetti, M, Marenzi, G, Margonato, A, Meloni, L, Metra, M, Milo, M, Mongiardo, A, Monzo, L, Morisco, C, Novo, G, Pancaldi, S, Parollo, M, Paterno, G, Patti, G, Priori, S, Ravera, A, Giuseppe Rebuzzi, A, Rossi, M, Scherillo, M, Semprini, F, Senni, M, Sibilio, G, Siviglia, M, Tamburino, C, Tortorici, G, Versace, F, Villari, B, Volpe, M, De Rosa S., Spaccarotella C., Basso C., Calabro M. P., Curcio A., Filardi P. P., Mancone M., Mercuro G., Muscoli S., Nodari S., Pedrinelli R., Sinagra G., Indolfi C., Angelini F., Barilla F., Bartorelli A., Benedetto F., Bernabo P., Bolognese L., Briani M., Cacciavillani L., Calabrese A., Calabro P., Caliendo L., Calo L., Casella G., Casu G., Cavallini C., Ciampi Q., Ciccone M., Comito M., Corrada E., Crea F., D'Andrea A., D'Urbano M., De Caterina R., De Ferrari G., De Ponti R., Della Mattia A., DI Mario C., Donnazzan L., Esposito G., Fedele F., Ferraro A., Galasso G., Galie N., Gnecchi M., Golino P., Golia B., Guarini P., Leonardi S., Locuratolo N., Luzza F., Manganiello V., Francesca Marchetti M., Marenzi G., Margonato A., Meloni L., Metra M., Milo M., Mongiardo A., Monzo L., Morisco C., Novo G., Pancaldi S., Parollo M., Paterno G., Patti G., Priori S., Ravera A., Giuseppe Rebuzzi A., Rossi M., Scherillo M., Semprini F., Senni M., Sibilio G., Siviglia M., Tamburino C., Tortorici G., Versace F., Villari B., Volpe M., De Rosa, S, Spaccarotella, C, Basso, C, Calabro, M, Curcio, A, Filardi, P, Mancone, M, Mercuro, G, Muscoli, S, Nodari, S, Pedrinelli, R, Sinagra, G, Indolfi, C, Angelini, F, Barilla, F, Bartorelli, A, Benedetto, F, Bernabo, P, Bolognese, L, Briani, M, Cacciavillani, L, Calabrese, A, Calabro, P, Caliendo, L, Calo, L, Casella, G, Casu, G, Cavallini, C, Ciampi, Q, Ciccone, M, Comito, M, Corrada, E, Crea, F, D'Andrea, A, D'Urbano, M, De Caterina, R, De Ferrari, G, De Ponti, R, Della Mattia, A, DI Mario, C, Donnazzan, L, Esposito, G, Fedele, F, Ferraro, A, Galasso, G, Galie, N, Gnecchi, M, Golino, P, Golia, B, Guarini, P, Leonardi, S, Locuratolo, N, Luzza, F, Manganiello, V, Francesca Marchetti, M, Marenzi, G, Margonato, A, Meloni, L, Metra, M, Milo, M, Mongiardo, A, Monzo, L, Morisco, C, Novo, G, Pancaldi, S, Parollo, M, Paterno, G, Patti, G, Priori, S, Ravera, A, Giuseppe Rebuzzi, A, Rossi, M, Scherillo, M, Semprini, F, Senni, M, Sibilio, G, Siviglia, M, Tamburino, C, Tortorici, G, Versace, F, Villari, B, Volpe, M, De Rosa S., Spaccarotella C., Basso C., Calabro M. P., Curcio A., Filardi P. P., Mancone M., Mercuro G., Muscoli S., Nodari S., Pedrinelli R., Sinagra G., Indolfi C., Angelini F., Barilla F., Bartorelli A., Benedetto F., Bernabo P., Bolognese L., Briani M., Cacciavillani L., Calabrese A., Calabro P., Caliendo L., Calo L., Casella G., Casu G., Cavallini C., Ciampi Q., Ciccone M., Comito M., Corrada E., Crea F., D'Andrea A., D'Urbano M., De Caterina R., De Ferrari G., De Ponti R., Della Mattia A., DI Mario C., Donnazzan L., Esposito G., Fedele F., Ferraro A., Galasso G., Galie N., Gnecchi M., Golino P., Golia B., Guarini P., Leonardi S., Locuratolo N., Luzza F., Manganiello V., Francesca Marchetti M., Marenzi G., Margonato A., Meloni L., Metra M., Milo M., Mongiardo A., Monzo L., Morisco C., Novo G., Pancaldi S., Parollo M., Paterno G., Patti G., Priori S., Ravera A., Giuseppe Rebuzzi A., Rossi M., Scherillo M., Semprini F., Senni M., Sibilio G., Siviglia M., Tamburino C., Tortorici G., Versace F., Villari B., and Volpe M.

Abstract

Aims: To evaluate the impact of the COVID-19 pandemic on patient admissions to Italian cardiac care units (CCUs). Methods and Results: We conducted a multicentre, observational, nationwide survey to collect data on admissions for acute myocardial infarction (AMI) at Italian CCUs throughout a 1 week period during the COVID-19 outbreak, compared with the equivalent week in 2019. We observed a 48.4% reduction in admissions for AMI compared with the equivalent week in 2019 (P < 0.001). The reduction was significant for both ST-segment elevation myocardial infarction [STEMI; 26.5%, 95% confidence interval (CI) 21.7-32.3; P = 0.009] and non-STEMI (NSTEMI; 65.1%, 95% CI 60.3-70.3; P < 0.001). Among STEMIs, the reduction was higher for women (41.2%; P = 0.011) than men (17.8%; P = 0.191). A similar reduction in AMI admissions was registered in North Italy (52.1%), Central Italy (59.3%), and South Italy (52.1%). The STEMI case fatality rate during the pandemic was substantially increased compared with 2019 [risk ratio (RR) = 3.3, 95% CI 1.7-6.6; P < 0.001]. A parallel increase in complications was also registered (RR = 1.8, 95% CI 1.1-2.8; P = 0.009). Conclusion: Admissions for AMI were significantly reduced during the COVID-19 pandemic across Italy, with a parallel increase in fatality and complication rates. This constitutes a serious social issue, demanding attention by the scientific and healthcare communities and public regulatory agencies.

Published
2020

27. Contratto di collaborazione autonoma e regime decadenziale ex art. 32, l. n. 183 del 2010

Author

Ciccone, M, Ciccone, M, Ciccone, M, and Ciccone, M

Abstract

Quando un rapporto di collaborazione autonoma si risolve per effetto della manifestazione di volontà del collaboratore di voler recedere dal rapporto, ovvero cessa per la sua naturale scadenza, l’azione per l’accertamento della subordinazione e la riammissione in servizio è esercitabile nei termini di prescrizione, senza essere assoggettata al regime decadenziale di cui all’art. 32, comma 3, lett. b), l. n. 183/2010, poiché il regime in questione si applica al solo caso di recesso del committente e non è estensibile alle ipotesi in cui manchi del tutto un atto che il lavoratore abbia interesse a contestare o confutare.

Published
2020

28. COVID-19 infection in acute lymphoblastic leukemia over 15 months of the pandemic. A Campus ALL report

Author

Chiaretti, S., Bonifacio, M., Agrippino, R., Giglio, F., Annunziata, M., Curti, A., Del Principe, M. I., Salutari, P., Sciume, M., Delia, M., Armenio, M., Mancini, V., Mule, A., Grimaldi, F., Rege-Cambrin, G., Santoro, L., Lussana, F., Chiusolo, Patrizia, Pasciolla, C., Scattolin, A. M., Cerrano, M., Ciccone, M., Defina, M., Forghieri, F., Mazzone, C., Piccini, M., Ferrara, F., Pizzolo, G., Foa, R., Chiusolo P. (ORCID:0000-0002-1355-1587), Chiaretti, S., Bonifacio, M., Agrippino, R., Giglio, F., Annunziata, M., Curti, A., Del Principe, M. I., Salutari, P., Sciume, M., Delia, M., Armenio, M., Mancini, V., Mule, A., Grimaldi, F., Rege-Cambrin, G., Santoro, L., Lussana, F., Chiusolo, Patrizia, Pasciolla, C., Scattolin, A. M., Cerrano, M., Ciccone, M., Defina, M., Forghieri, F., Mazzone, C., Piccini, M., Ferrara, F., Pizzolo, G., Foa, R., and Chiusolo P. (ORCID:0000-0002-1355-1587)

Abstract

N/A

Published
2022

33. Position paper of the Italian Society of Cardiology (SIC) on COVID-19 vaccine priority in patients with cardiovascular diseases

Author

Indolfi C., Barilla F., Basso C., Ciccone M. M., Curcio A., Mancone M., Mercuro G., Muscoli S., Nodari S., Pedrinelli R., Sinagra G., Filardi P. P., Romeo F., Indolfi, C., Barilla, F., Basso, C., Ciccone, M. M., Curcio, A., Mancone, M., Mercuro, G., Muscoli, S., Nodari, S., Pedrinelli, R., Romeo, F., Sinagra, G., and Filardi, P. P.

Subjects
Cardiovascular diseases, COVID-19, SARS-CoV-2, Vaccine, Age Factors, Animals, COVID-19 Vaccines, Cardiology, Cardiovascular Diseases, Coronary Disease, Disease Vectors, Heart Failure, Heart Transplantation, Heart Valve Diseases, Humans, Hypertension, Pulmonary, Italy, Prognosis, Renal Insufficiency, Societies, Medical, Vaccines, Synthetic, Consensus, Prognosi, COVID-19 Vaccine, Medical, Age Factor, Disease Vector, Vaccines, Animal, Synthetic, Pulmonary, Cardiovascular disease, Heart Valve Disease, Hypertension, Societies, Human
Abstract

In over a year, the COVID-19 pandemic caused 2.69 million deaths and 122 million infections. Social isolation and distancing measures have been the only prevention available for months. Scientific research has done a great deal of work, developing in a few months safe and effective vaccines against COVID-19. In the European Union, nowadays, four vaccines have been authorized for use: Pfizer-BioNTech, Moderna, ChAdOx1 (AstraZeneca/Oxford), Janssen (Johnson & Johnson), and three others are currently under rolling review. Vaccine allocation policy is crucial to optimize the advantage of treatment preferring people with the highest risk of contagion. These days the priority in the vaccination program is of particular importance since it has become clear that the number of vaccines is not sufficient for the entire Italian population in the short term. Cardiovascular diseases are frequently associated with severe COVID-19 infections, leading to the worst prognosis. The elderly population suffering from cardiovascular diseases is, therefore, to be considered a particularly vulnerable population. However, age cannot be considered the only discriminating factor because in the young-adult population suffering from severe forms of heart disease, the prognosis, if affected by COVID-19, is particularly ominous and these patients should have priority access to the vaccination program. The aim of this position paper is to establish a consensus on a priority in the vaccination of COVID-19 among subjects suffering from different cardiovascular diseases.

Published
2021

37. When should cardiovascular prevention begin? The importance of antenatal, perinatal and primordial prevention

Author

D'Ascenzi, F, Sciaccaluga, C, Cameli, M, Cecere, A, Ciccone, M, Di Francesco, S, Ganau, A, Imbalzano, E, Liga, R, Palermo, P, Palmiero, P, Parati, G, Pedrinelli, R, Scicchitano, P, Zito, A, Mattioli, A, D'Ascenzi F., Sciaccaluga C., Cameli M., Cecere A., Ciccone M. M., Di Francesco S., Ganau A., Imbalzano E., Liga R., Palermo P., Palmiero P., Parati G., Pedrinelli R., Scicchitano P., Zito A., Mattioli A. V., D'Ascenzi, F, Sciaccaluga, C, Cameli, M, Cecere, A, Ciccone, M, Di Francesco, S, Ganau, A, Imbalzano, E, Liga, R, Palermo, P, Palmiero, P, Parati, G, Pedrinelli, R, Scicchitano, P, Zito, A, Mattioli, A, D'Ascenzi F., Sciaccaluga C., Cameli M., Cecere A., Ciccone M. M., Di Francesco S., Ganau A., Imbalzano E., Liga R., Palermo P., Palmiero P., Parati G., Pedrinelli R., Scicchitano P., Zito A., and Mattioli A. V.

Abstract

Cardiovascular diseases represent a major health problem, being one of the leading causes of morbidity and mortality worldwide. Therefore, in this scenario, cardiovascular prevention plays an essential role although it is difficult to establish when promoting and implementing preventive strategies. However, there is growing evidence that prevention should start even before birth, during pregnancy, aiming to avoid the onset of cardiovascular risk factors, since events that occur early in life have a great impact on the cardiovascular risk profile of an adult. The two pillars of this early preventive strategy are nutrition and physical exercise, together with prevention of cardio-metabolic diseases during pregnancy. This review attempts to gather the growing evidence of the benefits of antenatal, perinatal and primordial prevention, discussing also the possibility to reverse or to mitigate the cardiovascular profile developed in the initial stages of life. This could pave the way for future research, investigating the optimal time and duration of these preventing measures, their duration and maintenance in adulthood, and the most effective interventions according to the different age and guiding in the next years, the best clinical practice and the political strategies to cope with cardiovascular disease.

Published
2019

38. Cardiovascular prevention in women: A narrative review from the Italian Society of Cardiology working groups on 'Cardiovascular Prevention, Hypertension and peripheral circulation' and on 'Women Disease'

Author

Mattioli, A, Sciomer, S, Moscucci, F, Maiello, M, Cugusi, L, Gallina, S, Dei Cas, A, Lombardi, C, Pengo, M, Parati, G, Barilla, F, Ciccone, M, Palmiero, P, Mercuro, G, Maffei, S, Mattioli A. V., Sciomer S., Moscucci F., Maiello M., Cugusi L., Gallina S., Dei Cas A., Lombardi C., Pengo M., Parati G., Barilla F., Ciccone M. M., Palmiero P., Mercuro G., Maffei S., Mattioli, A, Sciomer, S, Moscucci, F, Maiello, M, Cugusi, L, Gallina, S, Dei Cas, A, Lombardi, C, Pengo, M, Parati, G, Barilla, F, Ciccone, M, Palmiero, P, Mercuro, G, Maffei, S, Mattioli A. V., Sciomer S., Moscucci F., Maiello M., Cugusi L., Gallina S., Dei Cas A., Lombardi C., Pengo M., Parati G., Barilla F., Ciccone M. M., Palmiero P., Mercuro G., and Maffei S.

Abstract

Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in women.Some authors highlighted that the female risk profile consists of traditional and emerging risk factors. Despite the lower prevalence of type 2 diabetes, years of life lost owing to the disease for women are substantially higher compared with men. In addition, pregnancy complicated by gestational diabetes represents a risk factor for CVD. Women with gestational diabetes have a higher prevalence of coronary artery disease that occur at a younger age and are independent of T2DM.Hypertension is an important cardiovascular risk factor in women. Estrogens and progesterone, known to have an impact on blood pressure levels, have also been proposed to be protective against sleep-disordered breathing. It is very difficult to understand whereas obstructive sleep apnea in women is independently associated with hypertension or if many confounders acting at different stages of the woman lifespan mediate this relation.The cardioprotective effect of physical activity in women of all ages is well known. Women are generally more physically inactive than men. During and after menopause, most women tend to reduce their physical activity levels and together with the reduction in basal metabolic rate, women experience loss of skeletal muscle mass with a negative change in the ratio of fat-to-lean mass.In conclusion, sex differences in the cardiovascular system are because of dissimilarities in gene expression and sex hormones; these result in variations in prevalence and presentation of CVD and associated conditions, such as diabetes, hypertension and vascular and cardiac remodeling.Changes in lifestyle and increase in physical activity could help in prevention of cardiovascular disease in women.

Published
2019

40. Proliferation centers in chronic lymphocytic leukemia: correlation with cytogenetic and clinicobiological features in consecutive patients analyzed on tissue microarrays

Author

Ciccone, M, Agostinelli, C, Rigolin, G M, Piccaluga, P P, Cavazzini, F, Righi, S, Sista, M T, Sofritti, O, Rizzotto, L, Sabattini, E, Fioritoni, G, Falorio, S, Stelitano, C, Olivieri, A, Attolico, I, Brugiatelli, M, Zinzani, P L, Saccenti, E, Capello, D, Negrini, M, Cuneo, A, and Pileri, S

Published
2012
Full Text
View/download PDF

46. Reduction of hospitalizations for myocardial infarction in Italy in the COVID-19 era

Author

De Rosa, Miriam Stefania, Spaccarotella, C., Basso, C., Calabro, M. P., Curcio, A., Filardi, P. P., Mancone, M., Mercuro, G., Muscoli, S., Nodari, S., Pedrinelli, R., Sinagra, G., Indolfi, C., Angelini, F., Barilla, F., Bartorelli, A., Benedetto, F., Bernabo, P., Bolognese, L., Briani, M., Cacciavillani, L., Calabrese, Anna Chiara, Calabro, P., Caliendo, L., Calo, L., Casella, Gioietta, Casu, G., Cavallini, C., Ciampi, Q., Ciccone, M., Comito, M., Corrada, E., Crea, Filippo, D'Andrea, A., D'Urbano, M., De Caterina, R., De Ferrari, G., De Ponti, R., Della Mattia, A., Di Mario, Clara, Donnazzan, L., Esposito, Gianfranco, Fedele, F., Ferraro, A., Galasso, G., Galie, N., Gnecchi, M., Golino, P., Golia, B., Guarini, P., Leonardi, S., Locuratolo, N., Luzza, F., Manganiello, V., Francesca Marchetti, M., Marenzi, Giancarlo, Margonato, A., Meloni, L., Metra, M., Milo, Anna Maria, Mongiardo, A., Monzo, L., Morisco, C., Novo, G., Pancaldi, S., Parollo, M., Paterno, G., Patti, G., Priori, S., Ravera, A., Giuseppe Rebuzzi, A., Rossi, M., Scherillo, M., Semprini, F., Senni, M., Sibilio, G., Siviglia, M., Tamburino, C., Tortorici, G., Versace, F., Villari, B., Volpe, M., De Rosa S. (ORCID:0000-0002-8869-155X), Calabrese A., Casella G., Crea F. (ORCID:0000-0001-9404-8846), DI Mario C., Esposito G., Marenzi G., Milo M., De Rosa, Miriam Stefania, Spaccarotella, C., Basso, C., Calabro, M. P., Curcio, A., Filardi, P. P., Mancone, M., Mercuro, G., Muscoli, S., Nodari, S., Pedrinelli, R., Sinagra, G., Indolfi, C., Angelini, F., Barilla, F., Bartorelli, A., Benedetto, F., Bernabo, P., Bolognese, L., Briani, M., Cacciavillani, L., Calabrese, Anna Chiara, Calabro, P., Caliendo, L., Calo, L., Casella, Gioietta, Casu, G., Cavallini, C., Ciampi, Q., Ciccone, M., Comito, M., Corrada, E., Crea, Filippo, D'Andrea, A., D'Urbano, M., De Caterina, R., De Ferrari, G., De Ponti, R., Della Mattia, A., Di Mario, Clara, Donnazzan, L., Esposito, Gianfranco, Fedele, F., Ferraro, A., Galasso, G., Galie, N., Gnecchi, M., Golino, P., Golia, B., Guarini, P., Leonardi, S., Locuratolo, N., Luzza, F., Manganiello, V., Francesca Marchetti, M., Marenzi, Giancarlo, Margonato, A., Meloni, L., Metra, M., Milo, Anna Maria, Mongiardo, A., Monzo, L., Morisco, C., Novo, G., Pancaldi, S., Parollo, M., Paterno, G., Patti, G., Priori, S., Ravera, A., Giuseppe Rebuzzi, A., Rossi, M., Scherillo, M., Semprini, F., Senni, M., Sibilio, G., Siviglia, M., Tamburino, C., Tortorici, G., Versace, F., Villari, B., Volpe, M., De Rosa S. (ORCID:0000-0002-8869-155X), Calabrese A., Casella G., Crea F. (ORCID:0000-0001-9404-8846), DI Mario C., Esposito G., Marenzi G., and Milo M.

Abstract

Aims: To evaluate the impact of the COVID-19 pandemic on patient admissions to Italian cardiac care units (CCUs). Methods and Results: We conducted a multicentre, observational, nationwide survey to collect data on admissions for acute myocardial infarction (AMI) at Italian CCUs throughout a 1 week period during the COVID-19 outbreak, compared with the equivalent week in 2019. We observed a 48.4% reduction in admissions for AMI compared with the equivalent week in 2019 (P < 0.001). The reduction was significant for both ST-segment elevation myocardial infarction [STEMI; 26.5%, 95% confidence interval (CI) 21.7-32.3; P = 0.009] and non-STEMI (NSTEMI; 65.1%, 95% CI 60.3-70.3; P < 0.001). Among STEMIs, the reduction was higher for women (41.2%; P = 0.011) than men (17.8%; P = 0.191). A similar reduction in AMI admissions was registered in North Italy (52.1%), Central Italy (59.3%), and South Italy (52.1%). The STEMI case fatality rate during the pandemic was substantially increased compared with 2019 [risk ratio (RR) = 3.3, 95% CI 1.7-6.6; P < 0.001]. A parallel increase in complications was also registered (RR = 1.8, 95% CI 1.1-2.8; P = 0.009). Conclusion: Admissions for AMI were significantly reduced during the COVID-19 pandemic across Italy, with a parallel increase in fatality and complication rates. This constitutes a serious social issue, demanding attention by the scientific and healthcare communities and public regulatory agencies.

Published
2020

50. Significance of wait time for surgery on survival of women with early-stage cervical cancer

Author

Novatt, H., primary, Hom, M.S., additional, Castaneda, A.V., additional, Licon, E., additional, Nusbaum, D.J., additional, Blake, E.A., additional, Matsuzaki, S., additional, Ragab, O.M., additional, Ciccone, M., additional, Brunette, L.L., additional, Yessaian, A.A., additional, Muderspach, L.I., additional, Roman, L.D., additional, and Matsuo, K., additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results