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1. Lung cancer multi-omics digital human avatars for integrating precision medicine into clinical practice: the LANTERN study

Author

Lococo, F., Boldrini, L., Diepriye, C.-D., Evangelista, J., Nero, C., Flamini, S., Minucci, A., Paolis, E., Vita, E., Cesario, A., Annunziata, S., Calcagni, M., Chiappetta, M., Cancellieri, A., Larici, A., Cicchetti, G., (0000-0001-9550-9050) Troost, E. G. C., Róza, Á., Farré, N., Öztürk, E., Doorne, D., Leoncini, F., Urbani, A., Trisolini, R., Bria, E., Giordano, A., Rindi, G., Sala, E., Tortora, G., Valentini, V., Boccia, S., Margaritora, S., Scambia, G., Lococo, F., Boldrini, L., Diepriye, C.-D., Evangelista, J., Nero, C., Flamini, S., Minucci, A., Paolis, E., Vita, E., Cesario, A., Annunziata, S., Calcagni, M., Chiappetta, M., Cancellieri, A., Larici, A., Cicchetti, G., (0000-0001-9550-9050) Troost, E. G. C., Róza, Á., Farré, N., Öztürk, E., Doorne, D., Leoncini, F., Urbani, A., Trisolini, R., Bria, E., Giordano, A., Rindi, G., Sala, E., Tortora, G., Valentini, V., Boccia, S., Margaritora, S., and Scambia, G.

Abstract

Background The current management of lung cancer patients has reached a high level of complexity. Indeed, besides the traditional clinical variables (e.g., age, sex, TNM stage), new omics data have recently been introduced in clinical practice, thereby making more complex the decision-making process. With the advent of Artificial intelligence (AI) techniques, various omics datasets may be used to create more accurate predictive models paving the way for a better care in lung cancer patients. Methods The LANTERN study is a multi-center observational clinical trial involving a multidisciplinary consortium of five institutions from different European countries. The aim of this trial is to develop accurate several predictive models for lung cancer patients, through the creation of Digital Human Avatars (DHA), defined as digital representations of patients using various omics-based variables and integrating well-established clinical factors with genomic data, quantitative imaging data etc. A total of 600 lung cancer patients will be prospectively enrolled by the recruiting centers and multi-omics data will be collected. Data will then be modelled and parameterized in an experimental context of cutting-edge big data analysis. All data variables will be recorded according to a shared common ontology based on variable-specific domains in order to enhance their direct actionability. An exploratory analysis will then initiate the biomarker identification process. The second phase of the project will focus on creating multiple multivariate models trained though advanced machine learning (ML) and AI techniques for the specific areas of interest. Finally, the developed models will be validated in order to test their robustness, transferability and generalizability, leading to the development of the DHA. All the potential clinical and scientific stakeholders will be involved in the DHA development process. The main goals aim of LANTERN project are: i) To develop predictive models

Published
2023

2. Lung cancer multi-omics digital human avatars for integrating precision medicine into clinical practice: the LANTERN study

Author

Lococo, Filippo, Boldrini, Luca, Diepriye, C. -D., Evangelista, Jessica, Nero, Camilla, Flamini, S., Minucci, Angelo, De Paolis, Elisa, Vita, Emanuele, Cesario, Alfredo, Annunziata, Salvatore, Calcagni, Maria Lucia, Chiappetta, M., Cancellieri, Alessandra, Larici, Anna Rita, Cicchetti, Giuseppe, Troost, E. G. C., Roza, A., Farre, N., Ozturk, E., Van Doorne, D., Leoncini, F., Urbani, Andrea, Trisolini, Rocco, Bria, Emilio, Giordano, Alessandro, Rindi, Guido, Sala, Evi, Tortora, Giampaolo, Valentini, Vincenzo, Boccia, Stefania, Margaritora, Stefano, Scambia, Giovanni, Lococo F. (ORCID:0000-0002-9383-5554), Boldrini L., Evangelista J., Nero C., Minucci A., De Paolis E., Vita E., Cesario A. (ORCID:0000-0003-4687-0709), Annunziata S. (ORCID:0000-0003-3241-1501), Calcagni M. L. (ORCID:0000-0002-0805-8245), Cancellieri A., Larici A. R. (ORCID:0000-0002-1882-6244), Cicchetti G., Urbani A. (ORCID:0000-0001-9168-3174), Trisolini R., Bria E. (ORCID:0000-0002-2333-704X), Giordano A. (ORCID:0000-0002-6978-0880), Rindi G. (ORCID:0000-0003-2996-4404), Sala E., Tortora G. (ORCID:0000-0002-1378-4962), Valentini V. (ORCID:0000-0003-4637-6487), Boccia S. (ORCID:0000-0002-1864-749X), Margaritora S. (ORCID:0000-0002-9796-760X), Scambia G. (ORCID:0000-0003-2758-1063), Lococo, Filippo, Boldrini, Luca, Diepriye, C. -D., Evangelista, Jessica, Nero, Camilla, Flamini, S., Minucci, Angelo, De Paolis, Elisa, Vita, Emanuele, Cesario, Alfredo, Annunziata, Salvatore, Calcagni, Maria Lucia, Chiappetta, M., Cancellieri, Alessandra, Larici, Anna Rita, Cicchetti, Giuseppe, Troost, E. G. C., Roza, A., Farre, N., Ozturk, E., Van Doorne, D., Leoncini, F., Urbani, Andrea, Trisolini, Rocco, Bria, Emilio, Giordano, Alessandro, Rindi, Guido, Sala, Evi, Tortora, Giampaolo, Valentini, Vincenzo, Boccia, Stefania, Margaritora, Stefano, Scambia, Giovanni, Lococo F. (ORCID:0000-0002-9383-5554), Boldrini L., Evangelista J., Nero C., Minucci A., De Paolis E., Vita E., Cesario A. (ORCID:0000-0003-4687-0709), Annunziata S. (ORCID:0000-0003-3241-1501), Calcagni M. L. (ORCID:0000-0002-0805-8245), Cancellieri A., Larici A. R. (ORCID:0000-0002-1882-6244), Cicchetti G., Urbani A. (ORCID:0000-0001-9168-3174), Trisolini R., Bria E. (ORCID:0000-0002-2333-704X), Giordano A. (ORCID:0000-0002-6978-0880), Rindi G. (ORCID:0000-0003-2996-4404), Sala E., Tortora G. (ORCID:0000-0002-1378-4962), Valentini V. (ORCID:0000-0003-4637-6487), Boccia S. (ORCID:0000-0002-1864-749X), Margaritora S. (ORCID:0000-0002-9796-760X), and Scambia G. (ORCID:0000-0003-2758-1063)

Abstract

Background: The current management of lung cancer patients has reached a high level of complexity. Indeed, besides the traditional clinical variables (e.g., age, sex, TNM stage), new omics data have recently been introduced in clinical practice, thereby making more complex the decision-making process. With the advent of Artificial intelligence (AI) techniques, various omics datasets may be used to create more accurate predictive models paving the way for a better care in lung cancer patients. Methods: The LANTERN study is a multi-center observational clinical trial involving a multidisciplinary consortium of five institutions from different European countries. The aim of this trial is to develop accurate several predictive models for lung cancer patients, through the creation of Digital Human Avatars (DHA), defined as digital representations of patients using various omics-based variables and integrating well-established clinical factors with genomic data, quantitative imaging data etc. A total of 600 lung cancer patients will be prospectively enrolled by the recruiting centers and multi-omics data will be collected. Data will then be modelled and parameterized in an experimental context of cutting-edge big data analysis. All data variables will be recorded according to a shared common ontology based on variable-specific domains in order to enhance their direct actionability. An exploratory analysis will then initiate the biomarker identification process. The second phase of the project will focus on creating multiple multivariate models trained though advanced machine learning (ML) and AI techniques for the specific areas of interest. Finally, the developed models will be validated in order to test their robustness, transferability and generalizability, leading to the development of the DHA. All the potential clinical and scientific stakeholders will be involved in the DHA development process. The main goals aim of LANTERN project are: i) To develop predictive mode

Published
2023

3. Pulmonary Hypertension in Chronic Lung Diseases: What Role Do Radiologists Play?

Author

Valentini, A., Franchi, P., Cicchetti, Giuseppe, Messana, G., Chiffi, Greta, Strappa, Cecilia, Calandriello, Lucio, Del Ciello, Annemilia, Farchione, Alessandra, Preda, L., Larici, Anna Rita, Cicchetti G., Chiffi G., Strappa C., Calandriello L., del Ciello A., Farchione A., Larici A. R. (ORCID:0000-0002-1882-6244), Valentini, A., Franchi, P., Cicchetti, Giuseppe, Messana, G., Chiffi, Greta, Strappa, Cecilia, Calandriello, Lucio, Del Ciello, Annemilia, Farchione, Alessandra, Preda, L., Larici, Anna Rita, Cicchetti G., Chiffi G., Strappa C., Calandriello L., del Ciello A., Farchione A., and Larici A. R. (ORCID:0000-0002-1882-6244)

Abstract

Pulmonary hypertension (PH) is a pathophysiological disorder, defined by a mean pulmonary arterial pressure (mPAP) > 20 mmHg at rest, as assessed by right heart catheterization (RHC). PH is not a specific disease, as it may be observed in multiple clinical conditions and may complicate a variety of thoracic diseases. Conditions associated with the risk of developing PH are categorized into five different groups, according to similar clinical presentations, pathological findings, hemodynamic characteristics, and treatment strategy. Most chronic lung diseases that may be complicated by PH belong to group 3 (interstitial lung diseases, chronic obstructive pulmonary disease, combined pulmonary fibrosis, and emphysema) and are associated with the lowest overall survival among all groups. However, some of the chronic pulmonary diseases may develop PH with unclear/multifactorial mechanisms and are included in group 5 PH (sarcoidosis, pulmonary Langerhans' cell histiocytosis, and neurofibromatosis type 1). This paper focuses on PH associated with chronic lung diseases, in which radiological imaging-particularly computed tomography (CT)-plays a crucial role in diagnosis and classification. Radiologists should become familiar with the hemodynamical, physiological, and radiological aspects of PH and chronic lung diseases in patients at risk of developing PH, whose prognosis and treatment depend on the underlying disease.

Published
2023

5. Retinal vascular impairment matched to the pulmonary damage in early post-COVID 19 patients

Author

Savastano, Maria Cristina, Larici, Anna Rita, Crincoli, Emanuele, De Filippis, A., Cicchetti, Giuseppe, Gambini, Gloria, Savastano, Alfonso, Marano, Riccardo, Natale, Luigi, Rizzo, Stanislao, Savastano M. C. (ORCID:0000-0003-1397-4333), Larici A. R. (ORCID:0000-0002-1882-6244), Crincoli E., Cicchetti G., Gambini G., Savastano A., Marano R. (ORCID:0000-0003-2710-2093), Natale L. (ORCID:0000-0002-7949-5119), Rizzo S. (ORCID:0000-0001-6302-063X), Savastano, Maria Cristina, Larici, Anna Rita, Crincoli, Emanuele, De Filippis, A., Cicchetti, Giuseppe, Gambini, Gloria, Savastano, Alfonso, Marano, Riccardo, Natale, Luigi, Rizzo, Stanislao, Savastano M. C. (ORCID:0000-0003-1397-4333), Larici A. R. (ORCID:0000-0002-1882-6244), Crincoli E., Cicchetti G., Gambini G., Savastano A., Marano R. (ORCID:0000-0003-2710-2093), Natale L. (ORCID:0000-0002-7949-5119), and Rizzo S. (ORCID:0000-0001-6302-063X)

Abstract

Background: Endothelium damage is a crucial element in the pathogenesis of SARS-Cov-2 infection. Most casualties in critical COVID-19 cases are due to ARDS, diffuse coagulopathy and cytokine storm. ARDS itself is a consequence of pulmonary endothelial cells damage. Damage to retinal capillary microcirculation in post-infective period has been investigated through Optical Coherence Tomography Angiography (OCTA). The aim of the present study is to find a correlation between signs of retinal vascular damage and pulmonary impairment. Methods: Patients admitted to hospital and subsequently recovered from COVID-19 infection were summoned 1 month later to undergo coherence tomography (CT) scan and OCTA examination. Results: The study population included 87 COVID-19 patients with a mean age of 54.28 ± 14.44 years. Oxygen therapy, non-invasive and invasive mechanical ventilation were necessary in 33, 11 and 4 patients respectively to provide respiratory support during the acute course of the disease. Pulmonary involvement interested 54 patients (62.1%). Peripheral (27.6%) or diffuse (29.9%) involvement and ground glass (GG) opacities (47.1%) represented the prevalent radiological finding. A reduced RCPI FI was independently correlated with the presence of reticulation pattern in CT scan (p =.019). Also, RNFL and GCC were thinner in patients who displayed reticulation pattern (respectively p =.025 and p =.015). Conclusions: A reduction in RPCP-FI and RNFL and GCC thickness were independently correlated to the presence of CT reticulation pattern. This association can reflect cytokine induced remodeling in both organs as a consequence of systemic endothelial damage and inflammation.

Published
2022

7. Novelties in imaging of thoracic sarcoidosis

Author

Calandriello, Lucio, D'Abronzo, Rosa, Pasciuto, Giuliana, Cicchetti, Giuseppe, Del Ciello, Annemilia, Farchione, Alessandra, Strappa, Cecilia, Manfredi, Riccardo, Larici, Anna Rita, Calandriello L., D'abronzo R., Pasciuto G., Cicchetti G., Del Ciello A., Farchione A., Strappa C., Manfredi R. (ORCID:0000-0002-4972-9500), Larici AR. (ORCID:0000-0002-1882-6244), Calandriello, Lucio, D'Abronzo, Rosa, Pasciuto, Giuliana, Cicchetti, Giuseppe, Del Ciello, Annemilia, Farchione, Alessandra, Strappa, Cecilia, Manfredi, Riccardo, Larici, Anna Rita, Calandriello L., D'abronzo R., Pasciuto G., Cicchetti G., Del Ciello A., Farchione A., Strappa C., Manfredi R. (ORCID:0000-0002-4972-9500), and Larici AR. (ORCID:0000-0002-1882-6244)

Abstract

Sarcoidosis is a systemic granulomatous disease affecting various organs, and the lungs are the most commonly involved. According to guidelines, diagnosis relies on a consistent clinical picture, histological demonstration of non-caseating granulomas, and exclusion of other diseases with similar histological or clinical picture. Nevertheless, chest imaging plays an important role in both diagnostic assessment, allowing to avoid biopsy in some situations, and prognostic evaluation. Despite the demonstrated lower sensitivity of chest X-ray (CXR) in the evaluation of chest findings compared to high-resolution computed tomography (HRCT), CXR still retains a pivotal role in both diagnostic and prognostic assessment in sarcoidosis. Moreover, despite the huge progress made in the field of radiation dose reduction, chest magnetic resonance (MR), and quantitative imaging, very little research has focused on their application in sarcoidosis. In this review, we aim to describe the latest novelties in diagnostic and prognostic assessment of thoracic sarcoidosis and to identify the fields of research that require investigation.

Published
2021

8. Role of delayed phase contrast-enhanced CT in the intra-thoracic staging of non-small cell lung cancer (NSCLC): What does it add?

Author

Larici, Anna Rita, Franchi, P., Del Ciello, Annemilia, Sica, G., Coviello, D., De Waure, Chiara, Cicchetti, Giuseppe, Rovere, Giuseppe, Storto, M. L., Farchione, Alessandra, Calandriello, Lucio, D'Ambra, Giulia, Merlino, Biagio, Iezzi, Roberto, Marano, Riccardo, Manfredi, Riccardo, Larici AR. (ORCID:0000-0002-1882-6244), del Ciello A., De Waure C. (ORCID:0000-0002-4346-1494), Cicchetti G., Rovere G., Farchione A., Calandriello L., D'Ambra G., Merlino B. (ORCID:0000-0003-1104-3463), Iezzi R. (ORCID:0000-0002-2791-481X), Marano R. (ORCID:0000-0003-2710-2093), Manfredi R. (ORCID:0000-0002-4972-9500), Larici, Anna Rita, Franchi, P., Del Ciello, Annemilia, Sica, G., Coviello, D., De Waure, Chiara, Cicchetti, Giuseppe, Rovere, Giuseppe, Storto, M. L., Farchione, Alessandra, Calandriello, Lucio, D'Ambra, Giulia, Merlino, Biagio, Iezzi, Roberto, Marano, Riccardo, Manfredi, Riccardo, Larici AR. (ORCID:0000-0002-1882-6244), del Ciello A., De Waure C. (ORCID:0000-0002-4346-1494), Cicchetti G., Rovere G., Farchione A., Calandriello L., D'Ambra G., Merlino B. (ORCID:0000-0003-1104-3463), Iezzi R. (ORCID:0000-0002-2791-481X), Marano R. (ORCID:0000-0003-2710-2093), and Manfredi R. (ORCID:0000-0002-4972-9500)

Abstract

Purpose: The aim of the study was to investigate differences in non-small cell lung cancer (NSCLC) intra-thoracic staging by using contrast-enhanced computed tomography (ce-CT) at the arterial phase (AP), at the arterial plus delayed phases (AP + DEP), and at the delayed phase (DEP), and to evaluate their potential impact on disease staging. Materials and methods: Two chest radiologists with different level of expertise and a general radiologist independently reviewed the chest CT exams of 150 patients with NSCLC; CT scans were performed 40 s (AP) and 60 s (DEP) after contrast material injection. Image assessment included three reading sessions: session A (AP), session B (AP + DEP) and session C (DEP). CT descriptors for the primary tumour (T), regional nodal involvement (N), and intra-thoracic metastases (M) were evaluated in each reading session. Readers had to assign a confidence level (CL) for the assessment of each descriptor and define the TNM stage. Friedman and Cochran Q test was used to compare the assessments of the 3 reading sessions; inter-reader agreement was determined (Intraclass Correlation Coefficient – ICC). Results: The CL was significantly higher in sessions B and C than in session A for all descriptors, with the exception of pulmonary arterial invasion. Primary tumour inner necrosis and regional nodal involvement were detected in a significantly higher number of cases in sessions B and C as compared to session A (p ≤ 0.001). DEP significantly changed N stage determination (p < 0.001), particularly N3, and excluded chest wall invasion (p = 0.05) and venous invasion (p = 0.001). The agreement was good among the 3 readers (ICC = 0.761) and excellent between the 2 chest radiologists (ICC ≥ 0.940), regardless of the contrast phase. Conclusions: The 60-second DEP ce-CT for staging NSCLC significantly increased the readers’ CL, changed the N stage determination, and helped excluding chest wall invasion and venous invasion.

Published
2021

9. Corrigendum to “Multimodality imaging of COVID-19 pneumonia: From diagnosis to follow-up. A comprehensive review” [Eur. J. Radiol. 131 (October) (2020) 109217] (European Journal of Radiology (2020) 131, (S0720048X2030406X), (10.1016/j.ejrad.2020.109217))

Author

Larici, Anna Rita, Cicchetti, Giuseppe, Marano, Riccardo, Merlino, Biagio, Elia, Lorenzo, Calandriello, Lucio, Del Ciello, Annemilia, Farchione, Alessandra, Savino, Giancarlo, Infante, A., Larosa, Luigi, Colosimo, Cesare, Manfredi, Riccardo, Natale, Luigi, Larici A. R. (ORCID:0000-0002-1882-6244), Cicchetti G., Marano R. (ORCID:0000-0003-2710-2093), Merlino B. (ORCID:0000-0003-1104-3463), Elia L., Calandriello L., del Ciello A., Farchione A., Savino G., Larosa L., Colosimo C. (ORCID:0000-0003-3800-3648), Manfredi R. (ORCID:0000-0002-4972-9500), Natale L. (ORCID:0000-0002-7949-5119), Larici, Anna Rita, Cicchetti, Giuseppe, Marano, Riccardo, Merlino, Biagio, Elia, Lorenzo, Calandriello, Lucio, Del Ciello, Annemilia, Farchione, Alessandra, Savino, Giancarlo, Infante, A., Larosa, Luigi, Colosimo, Cesare, Manfredi, Riccardo, Natale, Luigi, Larici A. R. (ORCID:0000-0002-1882-6244), Cicchetti G., Marano R. (ORCID:0000-0003-2710-2093), Merlino B. (ORCID:0000-0003-1104-3463), Elia L., Calandriello L., del Ciello A., Farchione A., Savino G., Larosa L., Colosimo C. (ORCID:0000-0003-3800-3648), Manfredi R. (ORCID:0000-0002-4972-9500), and Natale L. (ORCID:0000-0002-7949-5119)

Abstract

The authors regret that Table 1 appeared incorrectly in the published version and should appear as follows. The authors would like to apologise for any inconvenience caused.

Published
2021

11. Multimodality imaging of COVID-19 pneumonia: from diagnosis to follow-up. Acomprehensive review

Author

Larici, Anna Rita, Cicchetti, Giuseppe, Marano, Riccardo, Merlino, Biagio, Elia, Lorenzo, Calandriello, Lucio, Del Ciello, Annemilia, Farchione, Alessandra, Savino, Giancarlo, Infante, A., Larosa, Luigi, Colosimo, Cesare, Manfredi, Riccardo, Natale, Luigi, Larici AR. (ORCID:0000-0002-1882-6244), Cicchetti G., Marano R. (ORCID:0000-0003-2710-2093), Merlino B. (ORCID:0000-0003-1104-3463), Elia L., Calandriello L., del Ciello A., Farchione A., Savino G., Larosa L., Colosimo C. (ORCID:0000-0003-3800-3648), Manfredi R. (ORCID:0000-0002-4972-9500), Natale L. (ORCID:0000-0002-7949-5119), Larici, Anna Rita, Cicchetti, Giuseppe, Marano, Riccardo, Merlino, Biagio, Elia, Lorenzo, Calandriello, Lucio, Del Ciello, Annemilia, Farchione, Alessandra, Savino, Giancarlo, Infante, A., Larosa, Luigi, Colosimo, Cesare, Manfredi, Riccardo, Natale, Luigi, Larici AR. (ORCID:0000-0002-1882-6244), Cicchetti G., Marano R. (ORCID:0000-0003-2710-2093), Merlino B. (ORCID:0000-0003-1104-3463), Elia L., Calandriello L., del Ciello A., Farchione A., Savino G., Larosa L., Colosimo C. (ORCID:0000-0003-3800-3648), Manfredi R. (ORCID:0000-0002-4972-9500), and Natale L. (ORCID:0000-0002-7949-5119)

Abstract

Due to its pandemic diffusion, SARS- CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infection represents a global threat. Despite a multiorgan involvement has been described, pneumonia is the most common manifestation of COVID-19 (Coronavirus disease 2019) and it is associated with a high morbidity and a considerable mortality. Especially in the areas with high disease burden, chest imaging plays a crucial role to speed up the diagnostic process and to aid the patient management. The purpose of this comprehensive review is to understand the diagnostic capabilities and limitations of chest X-ray (CXR) and high-resolution computed tomography (HRCT) in defining the common imaging features of COVID-19 pneumonia and correlating them with the underlying pathogenic mechanisms. The evolution of lung abnormalities over time, the uncommon findings, the possible complications, and the main differential diagnosis occurring in the pandemic phase of SARS-CoV-2 infection are also discussed.

Published
2020

12. Alemtuzumab-induced lung injury in multiple sclerosis: Learning from adversity in three patients

Author

Bianco, Assunta, Mari, Pier-Valerio, Larici, Anna Rita, Lucchini, Matteo, Nociti, Viviana, Losavio, Francesco Antonio, De Fino, Chiara, Cicchetti, Giuseppe, Coraci, Daniele, Richeldi, Luca, Mirabella, Massimiliano, Bianco A., Mari P. -V., Larici A. R. (ORCID:0000-0002-1882-6244), Lucchini M. (ORCID:0000-0002-0447-2297), Nociti V. (ORCID:0000-0002-4607-3948), Losavio F. A., De Fino C., Cicchetti G., Coraci D., Richeldi L. (ORCID:0000-0001-8594-1448), Mirabella M. (ORCID:0000-0002-7783-114X), Bianco, Assunta, Mari, Pier-Valerio, Larici, Anna Rita, Lucchini, Matteo, Nociti, Viviana, Losavio, Francesco Antonio, De Fino, Chiara, Cicchetti, Giuseppe, Coraci, Daniele, Richeldi, Luca, Mirabella, Massimiliano, Bianco A., Mari P. -V., Larici A. R. (ORCID:0000-0002-1882-6244), Lucchini M. (ORCID:0000-0002-0447-2297), Nociti V. (ORCID:0000-0002-4607-3948), Losavio F. A., De Fino C., Cicchetti G., Coraci D., Richeldi L. (ORCID:0000-0001-8594-1448), and Mirabella M. (ORCID:0000-0002-7783-114X)

Abstract

Background: Respiratory alemtuzumab-related adverse events are clinically heterogeneous and include respiratory infections, infusion-related dyspnea, hypoxia and secondary autoimmune disorders. Case report: Here we report three cases of drug-induced lung disease following treatment with alemtuzumab in multiple sclerosis patients. First case was diagnosed as a non-specified intestitial pneumonitis associated with organizing pneumonia with subacute onset, second case was an acute respiratory distress syndrome with onset during second cycle, third case was a diffuse acute alveolar hemorrhage during first cycle infusion. All patients developed acute respiratory failure, reversible after steroid therapy. Conclusions: Clinicians should be aware to early recognize acute and subacute respiratory adverse events for a promptly management. In these patients re-treatment is challenging.

Published
2020

14. Factors predicting active treatment free-survival and initial experience with mpMRI as a selection tool in patient undergoing active surveillance: 10-year follow-up of SIUrO PRIAS-ITA working group

Author

Roscigno, M., primary, Badenchini, F., additional, Napodano, G., additional, Borghesi, M., additional, Marenghi, C., additional, Magnani, T., additional, Simone, G., additional, Conti, G., additional, Guazzoni, G., additional, Tanello, M., additional, Ranieri, A., additional, Battaglia, M., additional, Lapini, A., additional, Altieri, V., additional, Bollito, E., additional, Cicchetti, G., additional, Colombo, P., additional, Colecchia, M., additional, Ditonno, P., additional, Fabiano, M., additional, Frego, E., additional, Rodolfo, H., additional, Montironi, R., additional, Patriarca, C., additional, Pili, A., additional, Paganelli, A., additional, Sanseverino, R., additional, Rancati, T., additional, Bangma, C., additional, Da Pozzo, L.F., additional, and Valdagni, R., additional

Published
2020
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15. Factors predicting active treatment free-survival: 10-year experience of active surveillance

Author

Roscigno, M., primary, Badenchini, F., additional, Borghesi, M., additional, Altieri, V., additional, Cicchetti, G., additional, Colombo, P., additional, Colecchia, M., additional, Da Pozzo, L.F., additional, Ditonno, P., additional, Fabiano, M., additional, Fiorentino, M., additional, Lapini, A., additional, Frego, E., additional, Gallucci, M., additional, Montironi, R., additional, Guazzoni, G., additional, Napodano, G., additional, Paolini, B., additional, Patriarca, C., additional, Pierconti, F., additional, Ranieri, A., additional, Tanello, M., additional, Magnani, T., additional, Conti, G., additional, and Valdagni, R., additional

Published
2020
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16. Impact of chest imaging quality on the diagnosis of the usual interstitial pneumonia pattern: a hub and spoke study

Author

Sgalla, Giacomo, Larici, Anna Rita, Re, A., Farchione, Alessandra, Cicchetti, Giuseppe, Calandriello, Lucio, Comes, Alessia, Golfi, Nicoletta, Iovene, Bruno, Varone, Francesco, Manfredi, Riccardo, Richeldi, Luca, Sgalla G. (ORCID:0000-0003-3130-9388), Larici A. R. (ORCID:0000-0002-1882-6244), Farchione A., Cicchetti G., Calandriello L., Comes A., Golfi N., Iovene B., Varone F., Manfredi R. (ORCID:0000-0002-4972-9500), Richeldi L. (ORCID:0000-0001-8594-1448), Sgalla, Giacomo, Larici, Anna Rita, Re, A., Farchione, Alessandra, Cicchetti, Giuseppe, Calandriello, Lucio, Comes, Alessia, Golfi, Nicoletta, Iovene, Bruno, Varone, Francesco, Manfredi, Riccardo, Richeldi, Luca, Sgalla G. (ORCID:0000-0003-3130-9388), Larici A. R. (ORCID:0000-0002-1882-6244), Farchione A., Cicchetti G., Calandriello L., Comes A., Golfi N., Iovene B., Varone F., Manfredi R. (ORCID:0000-0002-4972-9500), and Richeldi L. (ORCID:0000-0001-8594-1448)

Published
2019

18. Missed lung cancer: When, where, and why?

Author

del Ciello, A., Franchi, P., Contegiacomo, A., Cicchetti, G., Bonomo, Lorenzo, Larici, Anna Rita, Bonomo L. (ORCID:0000-0001-5101-9367), Larici A. R. (ORCID:0000-0002-1882-6244), del Ciello, A., Franchi, P., Contegiacomo, A., Cicchetti, G., Bonomo, Lorenzo, Larici, Anna Rita, Bonomo L. (ORCID:0000-0001-5101-9367), and Larici A. R. (ORCID:0000-0002-1882-6244)

Abstract

Missed lung cancer is a source of concern among radiologists and an important medicolegal challenge. In 90% of the cases, errors in diagnosis of lung cancer occur on chest radiographs. It may be challenging for radiologists to distinguish a lung lesion from bones, pulmonary vessels, mediastinal structures, and other complex anatomical structures on chest radiographs. Nevertheless, lung cancer can also be overlooked on computed tomography (CT) scans, regardless of the context, either if a clinical or radiologic suspect exists or for other reasons. Awareness of the possible causes of overlooking a pulmonary lesion can give radiologists a chance to reduce the occurrence of this eventuality. Various factors contribute to a misdiagnosis of lung cancer on chest radiographs and on CT, often very similar in nature to each other. Observer error is the most significant one and comprises scanning error, recognition error, decision-making error, and satisfaction of search. Tumor characteristics such as lesion size, conspicuity, and location are also crucial in this context. Even technical aspects can contribute to the probability of skipping lung cancer, including image quality and patient positioning and movement. Albeit it is hard to remove missed lung cancer completely, strategies to reduce observer error and methods to improve technique and automated detection may be valuable in reducing its likelihood.

Published
2017

19. SC244 - Factors predicting active treatment free-survival and initial experience with mpMRI as a selection tool in patient undergoing active surveillance: 10-year follow-up of SIUrO PRIAS-ITA working group

Author

Roscigno, M., Badenchini, F., Napodano, G., Borghesi, M., Marenghi, C., Magnani, T., Simone, G., Conti, G., Guazzoni, G., Tanello, M., Ranieri, A., Battaglia, M., Lapini, A., Altieri, V., Bollito, E., Cicchetti, G., Colombo, P., Colecchia, M., Ditonno, P., Fabiano, M., Frego, E., Rodolfo, H., Montironi, R., Patriarca, C., Pili, A., Paganelli, A., Sanseverino, R., Rancati, T., Bangma, C., Da Pozzo, L.F., and Valdagni, R.

Published
2020
Full Text
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21. Infezioni delle vie urinarie

Author

BERTACCINI, ALESSANDRO, FRANCESCHELLI, ALESSANDRO, MARTORANA, GIUSEPPE, SCHIAVINA, RICCARDO, Cicchetti G, Ferri C, Bertaccini A, Cicchetti G, Ferri C, Franceschelli A, Martorana G, and Schiavina R

Subjects
Infezioni delle vie urinarie
Abstract

disamina completa della fisiopatologia e del trattamento delle infezioni delle vie urinarie

Published
2008

22. TOMOGRAFIA COMPUTERIZZATA CON RICOSTRUZIONI 3D NELLO STUDIO POST-OPERATORIO DELLA NEOVESCICA ILEALE ORTOTOPICA

Author

CONCETTI, SERGIO, SCHIAVINA, RICCARDO, BRUNOCILLA, EUGENIO, MANFERRARI, FABIO, FRANCESCHELLI, ALESSANDRO, MARTORANA, GIUSEPPE, severini E., Cicchetti G., BATTISTA, GIUSEPPE, Zanzani S., S.Concetti, E.Brunocilla, R.Schiavina, E.Severini, F.Manferrari, A.Franceschelli, G.Cicchetti, G.Battista, S.Zanzani, G. Martorana, S. Concetti, R. Schiavina, E. Severini, E. Brunocilla, F. Manferrari, A. Franceschelli, G. Cicchetti, G. Battista, S. Zanzani, Concetti S., Schiavina R., severini E., Brunocilla E., Manferrari F., Franceschelli A., Cicchetti G., Battista G., Zanzani S., and Martorana G.

Subjects
TOMOGRAFIA COMPUTERIZZATA CON RICOSTRUZIONI 3D NELLO STUDIO POST-OPERATORIO DELLA NEOVESCICA ILEALE ORTOTOPICA
Abstract

TOMOGRAFIA COMPUTERIZZATA CON RICOSTRUZIONI 3D NELLO STUDIO POST-OPERATORIO DELLA NEOVESCICA ILEALE ORTOTOPICA

Published
2006

23. Valore predittivo del PSA density e del PSA free/totale nella biopsia prostatica

Author

Sanguedolce F., Palmieri F., Dababneh H., Cicchetti G., BERTACCINI, ALESSANDRO, MANFERRARI, FABIO, SCHIAVINA, RICCARDO, FRANCESCHELLI, ALESSANDRO, MARTORANA, GIUSEPPE, Sanguedolce F., Bertaccini A., Manferrari F., Schiavina R., Franceschelli A., Palmieri F., Dababneh H., Cicchetti G., and Martorana G.

Published
2006

24. Linfadenectomia standard vs estesa

Author

CONCETTI, SERGIO, BRUNOCILLA, EUGENIO, FRANCESCHELLI, ALESSANDRO, SCHIAVINA, RICCARDO, MARTORANA, GIUSEPPE, Sanguedolce F., Palmieri F., Urbinati M., Provenzale M., Dababneh H., Cicchetti G., Vitullo G., Concetti S., Brunocilla E., Sanguedolce F., Palmieri F., Franceschelli A., Schiavina R., Urbinati M., Provenzale M., Dababneh H., Cicchetti G., Vitullo G., and Martorana G.

Published
2006

25. Descrizione di un caso di feocromocitoma maligno non secernente

Author

SEVERINI, GIUSEPPE, MARTORANA, GIUSEPPE, Urbinati M., Romagnoli P., Cicchetti G., Costa F., Martinelli A., Severini E., Severini G., Urbinati M., Romagnoli P., Cicchetti G., Costa F., Martinelli A., Severini E., and Martorana G.

Published
2006

26. Validazione del nomogramma di Partin su una popolazione di prostatectomie radicali in Italia : esperienza di Bologna

Author

BRUNOCILLA, EUGENIO, SCHIAVINA, RICCARDO, FRANCESCHELLI, ALESSANDRO, BERTACCINI, ALESSANDRO, MARTORANA, GIUSEPPE, Sanguedolce F., Palmieri F., Urbinati M., Cicchetti G., Vitullo G., Gerace T., Martinelli A., Severini E., Brunocilla E., Sanguedolce F., Schiavina R., Franceschelli A., Palmieri F., Urbinati M., Cicchetti G., Vitullo G., Gerace T., Martinelli A., Severini E., Bertaccini A., and Martorana G.

Published
2005

27. Risk factors for type 2 diabetes in women attending menopause clinics in Italy: a cross-sectional study

Author

Di Donato, P, Giulini, N. A, Bacchi Modena, A, Cicchetti, G, Comitini, G, Gentile, G, Cristiani, P, Careccia, A, Esposito, E, Gualdi, F, Golinelli, S, Bergamini, E, Masellis, G, Rastelli, S, Gigli, C, Elia, A, Marchesoni, D, Sticotti, F, Del Frate, G, Zompicchiatti, C, Marino, L, Costa, M. R, Pinto, P, Dodero, D, Storace, A, Spinelli, G, Quaranta, S, Bossi, C. M, Ollago, A, Omodei, U, Vaccari, M, Luerti, M, Repetti, F, Zandonini, G, Raspagliesi, F, Dolci, F, Gambarino, G, De Pasquale, B, Polizzotti, G, Borsellino, G, Alpinelli, P, Natale, N, Colombo, D, Belloni, C, Viani, A, Cecchini, G, Vinci, G. W, Samaja, B. A, Pasinetti, E, Penotti, M, Ognissanti, F, Pesando, P, Malanetto, C, Gallo, M, Dolfin, G, Tartaglino, P, Mossotto, D, Pistoni, A, Tarani, A, Rattazzi, P. D, Rossaro, D, Campanella, M, Arisi, E, Gamper, M, Salvatores, D, Bocchin, E, Stellin, G, Meli, G, Azzini, V, Tirozzi, F, Buoso, G, Fraioli, R, Marsoni, V, Cetera, C, Sposetti, R, Candiotto, E, Pignalosa, R, Del Pup, L, Bellati, U, Angeloni, C, Buonerba, M, Garzarelli, S, Santilli, C, Mucci, M, Di Nisio, Q, Cappa, F, Pierangeli, I, Cordone, A, Falasca, L, Ferrante, D, Serra, G. B, Cirese, E, Todaro, P. A, Romanini, C, Spagnuolo, L, Lanzone, A, Donadio, C, Fabiani, M, Baldaccini, E, Votano, S, Bellardini, P, Favale, W, Monti, V, Bonomo, A, Boninfante, C. E, Pietrobattista, P, Massacesi, L, Donini, G, Del Savio, F, Palombi, L, Procaccioli, P, Romani, A, Romagnoli, G, Genazzani, A. R, Gambacciani, M, Scarselli, G, Curiel, P, De Leo, V, Melani, A, Levi D'Ancona, V, Giarrè, G, Di Gioia, E, Ceccarelli, P, Massi, G. B, Cosci, S, Gacci, G, Cascianini, A, Donati Sarti, C, Bircolotti, S, Pupita, P, Mincigrucci, M, Spadafora, A, Santeufemia, G, Marongiu, G, Lai, G. R, Lai, R, Dessole, S, D'Andrea, S. A, Coppola, Null, Chiantera, A, De Placido, Null, Arienzo, R, Pastore, A. R, Tamburrino, A, Cardone, A, Izzo, S, Tesauro, R, Pascarella, A, De Silvio, M. G, Di Prisco, L, Lauda, N, Sirimarco, F, Agrimi, C, Casarella, G, Senatore, G, Ronzini, S, Ruccia, G, De Carlo, G, Pisaturo, G, Carlomagno, F, Fasolino, A, Fiorillo, F, Sorrentino, R, Ercolano, V. B, Panariello, S, Brun, A, Tropea, P, Stigliano, C. M, Amoroso, A, Vadalà, P, Coco, A, Galati, G, Barese, G, Masciari, G, Pirillo, P, Gioffrè, T, Mastrantonio, P, Cardamone, A, D'Angelo, N, Valentino, G, Barretta, R, Ferraro, G, Ferruccio, C, Agostinelli, D, Corrado, G, Scopelliti, A, Schonauer, S, Trojano, V, Bongiovanni, F, Tinelli, F, Poddi, E. R, Scarpello, F, Colonna, L, Fischetti, G, Doria, R, Trombetta, G, Cocca, E. B, D'Amore, A, Di Masi, M, Liguori, R, Dimaggio, A, Laneve, M. R, Maolo, M. C, Gravina, G, Nacci, G, Nocera, F, Lupo, A, Giannola, C, Graziano, R, Mezzatesta, M, Vegna, G, Giannone, G, Palumbo, G, Cancellieri, F, Mondo, A, Cordopatri, A, Carrubba, M, Mazzola, V, Cincotta, L, D'Asta, S, Bono, A, Li Calsi, L, Cavallaro Nigro, S, Schilirò, S, Repici, A, Gullo, D, Orlando, A, Specchiale, F, Papotto, A, Abruzzo, Null, Basilicata, Null, Calabria, Null, Campania, Null, Emilia, Null, Romagna, Null, Giulia, Friuli Venezia, Lazio, Null, Liguria, Null, Lombardia, Null, Marche, Null, Molise, Null, Piemonte, Null, Puglia, Null, Sardegna, Null, Sicilia, Null, Toscana, Null, Adige, Trentino Alto, Umbria, Null, D'Aosta, Valle, Veneto, Null, Massacesi, A, De Aloysio, P, Campagnoli, C, Gambacciani, A, Graziottin, A, Baldi, C, Colacurci, N, Corrado Tonti, G, Parazzini, F, Chatenoud, L., COLACURCI, Nicola, Di Donato, P, Giulini, N. A, Bacchi Modena, A, Cicchetti, G, Comitini, G, Gentile, G, Cristiani, P, Careccia, A, Esposito, E, Gualdi, F, Golinelli, S, Bergamini, E, Masellis, G, Rastelli, S, Gigli, C, Elia, A, Marchesoni, D, Sticotti, F, Del Frate, G, Zompicchiatti, C, Marino, L, Costa, M. R, Pinto, P, Dodero, D, Storace, A, Spinelli, G, Quaranta, S, Bossi, C. M, Ollago, A, Omodei, U, Vaccari, M, Luerti, M, Repetti, F, Zandonini, G, Raspagliesi, F, Dolci, F, Gambarino, G, De Pasquale, B, Polizzotti, G, Borsellino, G, Alpinelli, P, Natale, N, Colombo, D, Belloni, C, Viani, A, Cecchini, G, Vinci, G. W, Samaja, B. A, Pasinetti, E, Penotti, M, Ognissanti, F, Pesando, P, Malanetto, C, Gallo, M, Dolfin, G, Tartaglino, P, Mossotto, D, Pistoni, A, Tarani, A, Rattazzi, P. D, Rossaro, D, Campanella, M, Arisi, E, Gamper, M, Salvatores, D, Bocchin, E, Stellin, G, Meli, G, Azzini, V, Tirozzi, F, Buoso, G, Fraioli, R, Marsoni, V, Cetera, C, Sposetti, R, Candiotto, E, Pignalosa, R, Del Pup, L, Bellati, U, Angeloni, C, Buonerba, M, Garzarelli, S, Santilli, C, Mucci, M, Di Nisio, Q, Cappa, F, Pierangeli, I, Cordone, A, Falasca, L, Ferrante, D, Serra, G. B, Cirese, E, Todaro, P. A, Romanini, C, Spagnuolo, L, Lanzone, A, Donadio, C, Fabiani, M, Baldaccini, E, Votano, S, Bellardini, P, Favale, W, Monti, V, Bonomo, A, Boninfante, C. E, Pietrobattista, P, Massacesi, L, Donini, G, Del Savio, F, Palombi, L, Procaccioli, P, Romani, A, Romagnoli, G, Genazzani, A. R, Gambacciani, M, Scarselli, G, Curiel, P, De Leo, V, Melani, A, Levi D'Ancona, V, Giarrè, G, Di Gioia, E, Ceccarelli, P, Massi, G. B, Cosci, S, Gacci, G, Cascianini, A, Donati Sarti, C, Bircolotti, S, Pupita, P, Mincigrucci, M, Spadafora, A, Santeufemia, G, Marongiu, G, Lai, G. R, Lai, R, Dessole, S, D'Andrea, S. A, Coppola, Null, Chiantera, A, De Placido, Null, Arienzo, R, Pastore, A. R, Tamburrino, A, Cardone, A, Colacurci, Nicola, Izzo, S, Tesauro, R, Pascarella, A, De Silvio, M. G, Di Prisco, L, Lauda, N, Sirimarco, F, Agrimi, C, Casarella, G, Senatore, G, Ronzini, S, Ruccia, G, De Carlo, G, Pisaturo, G, Carlomagno, F, Fasolino, A, Fiorillo, F, Sorrentino, R, Ercolano, V. B, Panariello, S, Brun, A, Tropea, P, Stigliano, C. M, Amoroso, A, Vadalà, P, Coco, A, Galati, G, Barese, G, Masciari, G, Pirillo, P, Gioffrè, T, Mastrantonio, P, Cardamone, A, D'Angelo, N, Valentino, G, Barretta, R, Ferraro, G, Ferruccio, C, Agostinelli, D, Corrado, G, Scopelliti, A, Schonauer, S, Trojano, V, Bongiovanni, F, Tinelli, F, Poddi, E. R, Scarpello, F, Colonna, L, Fischetti, G, Doria, R, Trombetta, G, Cocca, E. B, D'Amore, A, Di Masi, M, Liguori, R, Dimaggio, A, Laneve, M. R, Maolo, M. C, Gravina, G, Nacci, G, Nocera, F, Lupo, A, Giannola, C, Graziano, R, Mezzatesta, M, Vegna, G, Giannone, G, Palumbo, G, Cancellieri, F, Mondo, A, Cordopatri, A, Carrubba, M, Mazzola, V, Cincotta, L, D'Asta, S, Bono, A, Li Calsi, L, Cavallaro Nigro, S, Schilirò, S, Repici, A, Gullo, D, Orlando, A, Specchiale, F, Papotto, A, Abruzzo, Null, Basilicata, Null, Calabria, Null, Campania, Null, Emilia, Null, Romagna, Null, Giulia, Friuli Venezia, Lazio, Null, Liguria, Null, Lombardia, Null, Marche, Null, Molise, Null, Piemonte, Null, Puglia, Null, Sardegna, Null, Sicilia, Null, Toscana, Null, Adige, Trentino Alto, Umbria, Null, D'Aosta, Valle, Veneto, Null, Massacesi, A, De Aloysio, P, Campagnoli, C, Gambacciani, A, Graziottin, A, Baldi, C, Colacurci, N, Corrado Tonti, G, Parazzini, F, and Chatenoud, L.

Subjects
medicine.medical_specialty, Cross-sectional study, Hormone Replacement Therapy, medicine.medical_treatment, Type 2 diabetes, Motor Activity, Ambulatory Care Facilities, Age Distribution, Risk Factors, Diabetes mellitus, medicine, Odds Ratio, Humans, Obesity, Multivariate Analysi, menopausal status, Gynecology, Cross-Sectional Studie, diabetes, business.industry, Obstetrics, Risk Factor, Obstetrics and Gynecology, Hormone replacement therapy (menopause), General Medicine, Odds ratio, Middle Aged, medicine.disease, Educational Statu, Confidence interval, Menopause, Ambulatory Care Facilitie, women, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Italy, Multivariate Analysis, Educational Status, Female, business, Human
Abstract

To analyze risk factors for type 2 diabetes among women attending menopause clinics in Italy for counselling about the menopause.Women attending a network of first-level outpatient menopause clinics in Italy for general counselling about menopause or treatment of menopausal symptoms.Cross-sectional study with no exclusion criteria. Type 2 diabetes was defined according to National Diabetes Data Groups Indications and the fasting blood glucose at an oral glucose tolerance test within the previous year.Out of the 44 694 considered in this analysis, 808 had a diagnosis of diabetes type 2 (1.8%). In comparison with women aged50 years, the multivariate odds ratios (OR) of type 2 diabetes were 1.31 (95% confidence interval (CI), 0.99-1.74) for women aged 50-52 years, 1.66 (95% CI, 1.27-2.17) at 53-56 years and 2.84 (95% CI, 2.20-3.67) in women agedor = 57 years. Type 2 diabetes was less frequently reported in more educated women (OR high school/university vs. primary school = 0.44 (95% CI, 0.36-0.55)). Being overweight was associated with an increased risk of type 2 diabetes. In comparison with women reporting a low level of physical activity, the multivariate OR of type 2 diabetes was 0.67 (95% CI, 0.54-0.84) for women reporting regular physical activity. In comparison with premenopausal women, the multivariate OR of type 2 diabetes was 1.38 (95% CI, 1.03-1.84) in women with natural menopause. This finding was present also after allowing for the potential confounding effect of age. The multivariate OR of diabetes for users of hormonal replacement therapy was 0.58 (95% CI, 0.46-0.73).This large cross-sectional study suggests that postmenopausal women are at higher risk of type 2 diabetes after allowance for the effect of age. Other main determinants of risk of type 2 diabetes in women around menopause were low socioeconomic status and being overweight. Diabetes was found less frequently in those taking hormone replacement therapy.

Published
2005

28. Factors associated with climacteric symptoms in women around menopause attending menopause clinics in Italy

Author

Parazzini, Fabio, Di Donato, P., Giulini, N. A., Bacchi Modena, A., Cicchetti, G., Comitini, G., Gentile, G., Cristiani, P., Careccia, A., Esposito, E., Gualdi, F., Golinelli, S., Bergamini, E., Masellis, G., Rastelli, S., Gigli, C., Elia, A., Marchesoni, D., Sticotti, F., Del Frate, G., Zompicchiatti, C., Marino, L., Costa, M. R., Pinto, P., Dodero, D., Storace, A., Spinelli, G., Quaranta, S., Bossi, C. M., Ollago, A., Omodei, U., Vaccari, M., Luerti, M., Repetti, F., Zandonini, G., Raspagliesi, F., Dolci, F., Gambarino, G., De Pasquale, B., Polizzotti, G., Borsellino, G., Alpinelli, P., Natale, N., Colombo, D., Belloni, C., Viani, A., Cecchini, G., Vinci, G. W., Samaja, B. A., Pasinetti, E., Penotti, M., Ognissanti, F., Pesando, P., Malanetto, C., Gallo, M., Dolfin, G., Tartaglino, P., Mossotto, D., Pistoni, A., Tarani, A., Rattazzi, P. D., Rossaro, D., Campanella, M., Arisi, E., Gamper, M., Salvatores, D., Bocchin, E., Stellin, G., Meli, G., Azzini, V., Tirozzi, F., Buoso, G., Fraioli, R., Marsoni, V., Cetera, C., Sposetti, R., Candiotto, E., Pignalosa, R., Del Pup, L., Bellati, U., Angeloni, C., Buonerba, M., Garzarelli, S., Santilli, C., Mucci, M., Di Nisio, Q., Cappa, F., Pierangeli, I., Cordone, A., Falasca, L., Ferrante, D., Cirese, E., Todaro, P. A., Spagnuolo, L., Lanzone, A., Donadio, C., Fabiani, M., Baldaccini, E., Votano, S., Bellardini, P., Favale, W., Monti, V., Bonomo, A., Boninfante, C. E., Pietrobattista, P., Massacesi, L., Donini, G., Del Savio, F., Palombi, L., Procaccioli, P., Romani, A., Romagnoli, G., Genazzani, A. R., Gambacciani, M., Scarselli, G., Curiel, P., De Leo, V., Melani, A., Levi D'Ancona, V., Giarrè, G., Di Gioia, E., Ceccarelli, P., Massi, G. B., Cosci, S., Gacci, G., Cascianini, A., Donati Sarti, C., Bircolotti, S., Pupita, P., Mincigrucci, M., Spadafora, A., Santeufemia, G., Marongiu, G., Lai, G. R., Lai, R., Dessole, S., D'Andrea, S. A., Coppola, Null, Chiantera, A., De Placido, Null, Arienzo, R., Pastore, A. R., Tamburrino, A., Cardone, A., Izzo, S., Tesauro, R., Pascarella, A., De Silvio, M. G., Di Prisco, L., Lauda, N., Sirimarco, F., Agrimi, C., Casarella, G., Senatore, G., Ronzini, S., Ruccia, G., De Carlo, G., Pisaturo, G., Carlomagno, F., Fasolino, A., Fiorillo, F., Sorrentino, R., Ercolano, V. B., Panariello, S., Brun, A., Tropea, P., Stigliano, C. M., Amoroso, A., Vadalà, P., Coco, A., Galati, G., Barese, G., Masciari, G., Pirillo, P., Gioffrè, T., Mastrantonio, P., Cardamone, A., D'Angelo, N., Valentino, G., Barretta, R., Ferraro, G., Ferruccio, C., Agostinelli, D., Corrado, G., Scopelliti, A., Schonauer, S., Trojano, V., Bongiovanni, F., Tinelli, F., Poddi, E. R., Scarpello, F., Colonna, L., Fischetti, G., Doria, R., Trombetta, G., Cocca, E. B., D'Amore, A., Di Mas, M., Liguori, R., Dimaggio, A., Laneve, M. R., Maolo, M. C., Gravina, G., Nacci, G., Nocera, F., Lupo, A., Giannola, C., Graziano, R., Mezzatesta, M., Vegna, G., Giannone, G., Palumbo, G., Cancellieri, F., Mondo, A., Cordopatri, A., Carrubba, M., Mazzola, V., Cincotta, L., D'Asta, S., Bono, A., Li Calsi, L., Cavallaro Nigro, S., Schilirò, S., Repici, A., Gullo, D., Orlando, A., Specchial, F., Papotto, A., Abruzzo, Angeloni, Basilicata, D'Andrea, Calabria, Stigliano, Campania, Arienzo, Emilia, Di Donato, Romagna, Giulini, Friuli Venezia Giulia, Gigli, Lazio, Todaro, Liguria, Marino, Lombardia, Luerti, Marche, Donini, Molise, Ferrante, Piemonte, Dolfin, Puglia, Poddi, Sardegna, Santeufemia, Sicilia, Nocera, Toscana, Melani, Trentino Alto Adige, Arisi, Umbria, Mincigrucci, Valle D'Aosta, Salvatores, Veneto, Bocchin, Massacesi, A., De Aloysio, P., Campagnoli, C., Gambacciani, A., Graziottin, A., Baldi, C., Colacurci, N., Corrado Tonti, G., Chatenoud, L., COLACURCI, Nicola, Parazzini, Fabio, Di Donato, P., Giulini, N. A., Bacchi Modena, A., Cicchetti, G., Comitini, G., Gentile, G., Cristiani, P., Careccia, A., Esposito, E., Gualdi, F., Golinelli, S., Bergamini, E., Masellis, G., Rastelli, S., Gigli, C., Elia, A., Marchesoni, D., Sticotti, F., Del Frate, G., Zompicchiatti, C., Marino, L., Costa, M. R., Pinto, P., Dodero, D., Storace, A., Spinelli, G., Quaranta, S., Bossi, C. M., Ollago, A., Omodei, U., Vaccari, M., Luerti, M., Repetti, F., Zandonini, G., Raspagliesi, F., Dolci, F., Gambarino, G., De Pasquale, B., Polizzotti, G., Borsellino, G., Alpinelli, P., Natale, N., Colombo, D., Belloni, C., Viani, A., Cecchini, G., Vinci, G. W., Samaja, B. A., Pasinetti, E., Penotti, M., Ognissanti, F., Pesando, P., Malanetto, C., Gallo, M., Dolfin, G., Tartaglino, P., Mossotto, D., Pistoni, A., Tarani, A., Rattazzi, P. D., Rossaro, D., Campanella, M., Arisi, E., Gamper, M., Salvatores, D., Bocchin, E., Stellin, G., Meli, G., Azzini, V., Tirozzi, F., Buoso, G., Fraioli, R., Marsoni, V., Cetera, C., Sposetti, R., Candiotto, E., Pignalosa, R., Del Pup, L., Bellati, U., Angeloni, C., Buonerba, M., Garzarelli, S., Santilli, C., Mucci, M., Di Nisio, Q., Cappa, F., Pierangeli, I., Cordone, A., Falasca, L., Ferrante, D., Cirese, E., Todaro, P. A., Spagnuolo, L., Lanzone, A., Donadio, C., Fabiani, M., Baldaccini, E., Votano, S., Bellardini, P., Favale, W., Monti, V., Bonomo, A., Boninfante, C. E., Pietrobattista, P., Massacesi, L., Donini, G., Del Savio, F., Palombi, L., Procaccioli, P., Romani, A., Romagnoli, G., Genazzani, A. R., Gambacciani, M., Scarselli, G., Curiel, P., De Leo, V., Melani, A., Levi D'Ancona, V., Giarrè, G., Di Gioia, E., Ceccarelli, P., Massi, G. B., Cosci, S., Gacci, G., Cascianini, A., Donati Sarti, C., Bircolotti, S., Pupita, P., Mincigrucci, M., Spadafora, A., Santeufemia, G., Marongiu, G., Lai, G. R., Lai, R., Dessole, S., D'Andrea, S. A., Coppola, Null, Chiantera, A., De Placido, Null, Arienzo, R., Pastore, A. R., Tamburrino, A., Cardone, A., Colacurci, Nicola, Izzo, S., Tesauro, R., Pascarella, A., De Silvio, M. G., Di Prisco, L., Lauda, N., Sirimarco, F., Agrimi, C., Casarella, G., Senatore, G., Ronzini, S., Ruccia, G., De Carlo, G., Pisaturo, G., Carlomagno, F., Fasolino, A., Fiorillo, F., Sorrentino, R., Ercolano, V. B., Panariello, S., Brun, A., Tropea, P., Stigliano, C. M., Amoroso, A., Vadalà, P., Coco, A., Galati, G., Barese, G., Masciari, G., Pirillo, P., Gioffrè, T., Mastrantonio, P., Cardamone, A., D'Angelo, N., Valentino, G., Barretta, R., Ferraro, G., Ferruccio, C., Agostinelli, D., Corrado, G., Scopelliti, A., Schonauer, S., Trojano, V., Bongiovanni, F., Tinelli, F., Poddi, E. R., Scarpello, F., Colonna, L., Fischetti, G., Doria, R., Trombetta, G., Cocca, E. B., D'Amore, A., Di Mas, M., Liguori, R., Dimaggio, A., Laneve, M. R., Maolo, M. C., Gravina, G., Nacci, G., Nocera, F., Lupo, A., Giannola, C., Graziano, R., Mezzatesta, M., Vegna, G., Giannone, G., Palumbo, G., Cancellieri, F., Mondo, A., Cordopatri, A., Carrubba, M., Mazzola, V., Cincotta, L., D'Asta, S., Bono, A., Li Calsi, L., Cavallaro Nigro, S., Schilirò, S., Repici, A., Gullo, D., Orlando, A., Specchial, F., Papotto, A., Abruzzo, Angeloni, Basilicata, D'Andrea, Calabria, Stigliano, Campania, Arienzo, Emilia, Di Donato, Romagna, Giulini, Friuli Venezia Giulia, Gigli, Lazio, Todaro, Liguria, Marino, Lombardia, Luerti, Marche, Donini, Molise, Ferrante, Piemonte, Dolfin, Puglia, Poddi, Sardegna, Santeufemia, Sicilia, Nocera, Toscana, Melani, Trentino Alto Adige, Arisi, Umbria, Mincigrucci, Valle D'Aosta, Salvatore, Veneto, Bocchin, Massacesi, A., De Aloysio, P., Campagnoli, C., Gambacciani, A., Graziottin, A., Baldi, C., Colacurci, N., Corrado Tonti, G., and Chatenoud, L.

Subjects
Aging, Epidemiology, Cross-sectional study, Marital Statu, Ambulatory Care Facilities, Body Mass Index, Age Factor, Reproductive History, Depression (differential diagnoses), Depression, Smoking, Age Factors, Headache, Obstetrics and Gynecology, Middle Aged, Menopause, Italy, Educational Status, Female, medicine.symptom, Climacteric, Human, Adult, medicine.medical_specialty, Hot Flashe, Logistic Model, Symptom, Irritability, General Biochemistry, Genetics and Molecular Biology, medicine, Humans, Aged, Cross-Sectional Studie, Marital Status, business.industry, Odds ratio, medicine.disease, Educational Statu, Diet, Ambulatory Care Facilitie, Cross-Sectional Studies, Logistic Models, Risk factors, Hot Flashes, Symptoms, Physical therapy, Risk factor, business, Body mass index, Demography
Abstract

OBJECTIVE To obtain data on correlates of climacteric symptoms in women around menopause attending menopause clinics in Italy. METHODS Since 1997 a large cross sectional study has been conducted on the characteristics of women around menopause attending a network of first level menopause outpatient's clinics in Italy. A total of 66,501 (mean age 54.4 years) women are considered in the present paper. RESULTS The odds ratios of moderate and severe hot flashes/night sweats were lower in more educated women and (for severe symptoms only) in women reporting regular physical activity. Depression, difficulty to sleep, forgetfulness and irritability tended to be less frequent in more educated women and (depression only) in women reporting regular physical activity. Parous women reported more frequently these symptoms. CONCLUSIONS This large study confirms in Southern European population that low education, body mass index and low physical activity are associated with climacteric symptoms. Parous women are at greater risk of psychological symptoms.

Published
2005

29. 1037 SIUrO-PRIAS-ITA project: Five year experience on active surveillance

Author

Badenchini, F., primary, Conti, G., additional, Gallucci, M., additional, Papalia, R., additional, Martorana, G., additional, Diazzi, D., additional, Sanseverino, R., additional, Napodano, G., additional, Frego, E., additional, Tanello, M., additional, Taverna, G., additional, Proietti, S., additional, Turci, A., additional, Cicchetti, G., additional, Ditonno, P., additional, Bollito, E., additional, Colecchia, M., additional, Fiorentino, M., additional, Montironi, R., additional, Patriarca, C., additional, Raspollini, M.R., additional, Sentinelli, S., additional, Rancati, T., additional, Magnani, T., additional, Bangma, C., additional, and Valdagni, R., additional

Published
2015
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31. Determinants of body mass index in women around menopause attending menopause clinics in Italy

Author

DE ALOYSIO, D, DI DONATO, P, Giulini, Na, Modena, Ab, Cicchetti, G, Comitini, G, Gentile, G, Cristiani, P, Careccia, A, Esposito, E, Gualdi, F, Golinelli, S, Bergamini, E, Masellis, G, Rastelli, S, Gigli, C, Elia, A, Marchesoni, D, Sticotti, F, DEL FRATE, G, Zompicchiatti, C, Marino, L, Costa, Mr, Pinto, P, Dodero, D, Storace, A, Spinelli, G, Quaranta, S, Bossi, Cm, Ollago, A, Omodei, U, Vaccari, M, Luerti, M, Repetti, F, Zandonini, G, Raspagliesi, F, Dolci, F, Gambarino, G, DE PASQUALE, B, Polizzotti, G, Borsellino, G, Alpinelli, P, Natale, N, Colombo, D, Belloni, C, Viani, A, Cecchini, G, Vinci, Gw, Samaja, Ba, Pasinetti, E, Penotti, M, Ognissanti, F, Pesando, P, Malanetto, C, Gallo, M, Dolfin, G, Tartaglino, P, Mossotto, D, Pistoni, A, Tarani, A, Rattazzi, Pd, Rossaro, D, Campanella, M, Arisi, E, Gamper, M, Salvatores, D, Bocchin, E, Stellin, G, Meli, G, Azzini, V, Tirozzi, F, Buoso, G, Fraioli, R, Marsoni, V, Cetera, C, Sposetti, R, Candiotto, E, Pignalosa, R, DEL PUP, L, Bellati, U, Angeloni, C, Buonerba, M, Garzarelli, S, Santilli, C, Mucci, M, DI NISIO, Q, Cappa, F, Pierangeli, I, Cordone, A, Falasca, L, Ferrante, D, Cirese, E, Todaro, Pa, Spagnuolo, L, Lanzone, A, Donadio, C, Fabiani, M, Baldaccini, E, Votano, S, Bellardini, P, Favale, W, Monti, V, Bonomo, A, Boninfante, Ce, Pietrobattista, P, Massacesi, L, Donini, G, DEL SAVIO, F, Palombi, L, Procaccioli, P, Romani, A, Romagnoli, G, Genazzani, Ar, Gambacciani, M, Scarselli, G, Curiel, P, DE LEO, V, Melani, A, D'Ancona, Vl, Giarre, G, DI GIOIA, E, Ceccarelli, P, Massi, Gb, Cosci, S, Gacci, G, Cascianini, A, Sarti, Cd, Bircolotti, S, Pupita, P, Mincigrucci, M, Spadafora, A, Santeufemia, G, Marongiu, G, Lai, Gr, Lai, R, Dessole, S, D'Andrea, Sa, Coppola, Chiantera, A, Placido, De, Arienzo, R, Pastore, Ar, Tamburrino, A, Cardone, A, Colacurci, N, Izzo, S, Tesauro, R, Pascarella, A, DE SILVIO MG, DI PRISCO, L, Lauda, N, Sirimarco, F, Agrimi, C, Casarella, G, Senatore, G, Ronzini, S, Ruccia, G, DE CARLO, G, Pisaturo, G, Carlomagno, F, Fasolino, A, Fiorillo, F, Sorrentino, R, Ercolano, Vb, Panariello, S, Brun, A, Tropea, P, Stigliano, Cm, Amoroso, A, Vadala, P, Coco, A, Galati, G, Barese, G, Masciari, G, Pirillo, P, Gioffre, T, Mastrantonio, P, Cardamone, A, D'Angelo, N, Valentino, G, Barretta, R, Ferraro, G, Ferruccio, C, Agostinelli, D, Corrado, G, Scopelliti, A, Schonauer, S, Trojano, V, Bongiovanni, F, Tinelli, F, Poddi, Er, Scarpello, F, Colonna, L, Fischetti, G, Doria, R, Trombetta, G, Cocca, Eb, D'Amore, A, DI MASI, M, Liguori, R, Dimaggio, A, Laneve, Mr, Maolo, Mc, Gravina, G, Nacci, G, Nocera, F, Lupo, A, Giannola, C, Graziano, R, Mezzatesta, M, Vegna, G, Giannone, G, Palumbo, G, Cancellieri, Francesco, Mondo, A, Cordopatri, A, Carrubba, M, Mazzola, V, D'Asta, S, Bono, A, Calsi, Ll, Nigro, Sc, Schiliro, S, Repici, A, Gullo, D, Orlando, A, Specchiale, F, Papotto, A, Massacesi, A, DE ALOYSIO, P, Campagnoli, C, Gambacciani, A, Graziottin, A, Baldi, C, Parazzini, F, Chatenoud, L, and Chiaffarino, F.

Published
2003

32. Premature ovarian failure: frequency and risk factors among women attending a network of menopause clinics in Italy

Author

DE ALOYSIO, D, DI DONATO, P, Giulini, Na, Modena, Ab, Cicchetti, G, Comitini, G, Gentile, G, Cristiani, P, Careccia, A, Esposito, E, Gualdi, F, Golinelli, S, Bergamini, E, Masellis, G, Rastelli, S, Gigli, C, Elia, A, Marchesoni, D, Sticotti, F, DEL FRATE, G, Zompicchiatti, C, Marino, L, Costa, Mr, Pinto, P, Dodero, D, Storace, A, Spinelli, G, Quaranta, S, Bossi, Cm, Ollago, A, Omodei, U, Vaccari, M, Luerti, M, Repetti, F, Zandonini, G, Raspagliesi, F, Dolci, F, Gambarino, G, DE PASQUALE, B, Polizzotti, G, Borsellino, G, Alpinelli, P, Natale, N, Colombo, D, Belloni, C, Viani, A, Cecchini, G, Vinci, Gw, Samaja, Ba, Pasinetti, E, Penotti, M, Ognissanti, F, Pesando, P, Malanetto, C, Gallo, M, Dolfin, G, Tartaglino, P, Mossotto, D, Pistoni, A, Tarani, A, Rattazzi, Pd, Rossaro, D, Campanella, M, Arisi, E, Gamper, M, Salvatores, D, Bocchin, E, Stellin, G, Meli, G, Azzini, V, Tirozzi, F, Buoso, G, Fraioli, R, Marsoni, V, Cetera, C, Sposetti, R, Candiotto, E, Pignalosa, R, DEL PUP, L, Bellati, U, Angeloni, C, Buonerba, M, Garzarelli, S, Santilli, C, Mucci, M, DI NISIO, Q, Cappa, F, Pierangeli, I, Cordone, A, Falasca, L, Ferrante, D, Serra, Gb, Cirese, E, Todaro, Pa, Romanini, C, Spagnuolo, L, Lanzone, A, Donadio, C, Fabiani, M, Baldaccini, E, Votano, S, Bellardini, P, Favale, W, Monti, V, Bonomo, A, Boninfante, Ce, Pietrobattista, P, Massacesi, L, Donini, G, DEL SAVIO, F, Palombi, L, Procaccioli, P, Romani, A, Romagnoli, G, Genazzani, Ar, Gambacciani, M, Scarselli, G, Curiel, P, DE LEO, V, Melani, A, D'Ancona, Vl, Lorenzo, Bs, Giarre, G, DI GIOIA, E, Ceccarelli, P, Massi, Gb, Cosci, S, Gacci, G, Cascianini, A, Sarti, Cd, Bircolotti, S, Pupita, P, Mincigrucci, M, Spadafora, A, Santeufemia, G, Marongiu, G, Lai, Gr, Lai, R, Dessole, S, D'Andrea, Sa, Coppola, Chiantera, A, Placido, D, Arienzo, R, Pastore, Ar, Tamburrino, A, Cardone, A, Colacurci, N, Izzo, S, Tesauro, R, Pascarella, A, DE SILVIO MG, DI PRISCO, L, Lauda, N, Sirimarco, F, Agrimi, C, Casarella, G, Senatore, G, Ronzini, S, Ruccia, G, DE CARLO, G, Pisaturo, G, Carlomagno, F, Fasolino, A, Fiorillo, F, Sorrentino, R, Ercolano, Vb, Panariello, S, Brun, A, Tropea, P, Stigliano, Cm, Amoroso, A, Vadala, P, Coco, A, Galati, G, Barese, G, Masciari, G, Pirillo, P, Mastrantonio, P, Cardamone, A, D'Angelo, N, Valentino, G, Barretta, R, Ferraro, G, Ferruccio, C, Agostinelli, D, Corrado, G, Scopelliti, A, Schonauer, S, Trojano, V, Bongiovanni, F, Tinelli, F, Poddi, Er, Scarpello, F, Colonna, L, Fischetti, G, Doria, R, Trombetta, G, Cocca, Eb, D'Amore, A, DI MASI, M, Liguori, R, Dimaggio, A, Laneve, Mr, Maolo, Mc, Gravina, G, Nacci, G, Nocera, F, Lupo, A, Giannola, C, Graziano, R, Mezzatesta, M, Vegna, G, Giannone, G, Palumbo, G, Cancellieri, Francesco, Mondo, A, Cordopatri, A, Carrubba, M, Mazzola, V, Cincotta, L, D'Asta, S, Bono, A, Calsi, Ll, Nigro, Sc, Schiliro, S, Repici, A, Gullo, D, Orlando, A, Specchiale, F, and Papotto, A.

Published
2003

33. Risk of low bone density in women attending menopause clinics in Italy

Author

DE ALOYSIO, D, DI DONATO, P, Giulini, Na, Modena, B, Cicchetti, G, Comitini, G, Gentile, G, Cristiani, P, Careccia, A, Esposito, E, Gigli, C, Mandruzzato, G, Petraglia, F, Bertelli, F, DEL FRATE, G, Garofalo, S, Marino, L, Costa, Mr, Quaranta, S, Bossi, Cm, Amantea, P, Omodei, U, Vaccari, M, Luerti, M, Repetti, F, Zandonini, G, Raspagliesi, F, Dolci, F, Zacchi, V, Bennici, S, Polizzotti, G, Bottino, S, Raffaelli, F, Minervini, C, Colombo, D, Belloni, C, Viani, A, Cecchini, G, Winkler, S, Samaja, Ba, Pasinetti, E, Penotti, M, Malanetto, C, Massobrio, M, Campagnoli, C, Dolfin, G, Tartaglino, P, Mossotto, D, Pesando, P, Pacilli, L, Rattazzi, Pd, Arisi, E, Gamper, M, Salvatores, D, Bocchin, E, Stellin, G, Meli, G, Azzini, V, Tirozzi, F, Buoso, G, Fraioli, R, Marsoni, V, Cetera, C, Sposetti, R, Bellati, U, Angeloni, C, Buonerba, M, Garzarelli, S, Santilli, C, Mucci, M, DI NISIO, Q, Falasca, L, Ferrante, D, Cirese, E, Todaro, Pa, Romanini, C, Spagnuolo, L, Lanzone, A, Donadio, C, Fabiani, M, Baldaccini, E, Votano, S, Serra, Gb, Bellardini, P, Massacesi, L, Donini, G, Genazzani, Ra, Scarselli, G, Curiel, P, DE LEO, V, Melani, A, D'Ancona, Vl, Giarre, G, DI GIOIA, E, Ciccarelli, P, Sarti, Cd, Balsotti, G, Pupita, P, Mincigrucci, M, Spadafora, A, Santeufemia, G, D'Andrea, A, Chiantera, A, Montemagno, U, Staiano, S, Arienzo, R, Pastore, Ar, Tamburrino, A, Colacurci, A, Izzo, S, Zumpano, N, Pascarella, A, DE SILVIO MG, DI PRISCO, L, Lauda, N, Sorrentino, O, Agrimi, C, Casarella, G, Pisaturo, G, Senatore, G, Ruccia, G, Fasolino, A, Tropea, P, Stigliano, Cm, Giannice, C, Vadala, P, Coco, A, Lombardo, R, Barese, G, Masciari, G, Pirillo, P, Gioffre, T, Ferruccio, C, Agostinelli, D, Tonti, Gc, Scopelliti, A, Schonauer, S, Bongiovanni, F, Tinelli, F, Poddi, Er, Scarpello, F, Colonna, L, Fischetti, G, Doria, R, Trombetta, G, Cocca, Eb, Carone, D, Nocera, F, Giambanco, V, Giannola, C, Graziano, R, Mezzatesta, M, Vegna, G, Giannone, G, Palumbo, G, Cancellieri, Francesco, Mondo, A, Cordopatri, A, Carrubba, M, Mazzola, V, Ettore, G, D'Asta, S, DI LIBERTO, P, Massacesi, A, DE ALOYSIO, P, Ognissanti, F, Gambacciani, A, Graziottin, A, Baldi, C, Colacurci, N, and Parazzini, F.

Published
2002

34. General and medical factors associated with hormone replacement therapy among women attending menopause clinics in Italy

Author

DE ALOYSIO, D, DI DONATO, P, Giulini, Na, Modena, B, Cicchetti, G, Comitini, G, Gentile, G, Cristiani, P, Careccia, A, Esposito, E, Gigli, C, Mandruzzato, G, Petraglia, F, Bertelli, F, DEL FRATE, G, Garofalo, S, Marino, L, Costa, Mr, Quaranta, S, Bossi, Cm, Amantea, P, Omodei, U, Vaccari, M, Luerti, M, Repetti, F, Zandonini, G, Raspagliesi, F, Dolci, F, Zacchi, V, Bennici, S, Polizzotti, G, Bottino, S, Raffaelli, F, Minervini, C, Colombo, D, Belloni, C, Viani, A, Cecchini, G, Winkler, S, Samaja, Ba, Pasinetti, E, Penotti, M, Malanetto, C, Massobrio, M, Campagnoli, C, Dolfin, G, Tartaglino, P, Mossotto, D, Pesando, P, Pacilli, L, Rattazzi, Pd, Arisi, E, Gamper, M, Salvatores, D, Bocchin, E, Stellin, G, Meli, G, Azzini, V, Tirozzi, F, Buoso, G, Fraioli, R, Marsoni, V, Cetera, C, Sposetti, R, Bellati, U, Angeloni, C, Buonerba, M, Garzarelli, S, Santilli, C, Mucci, M, DI NISIO, Q, Falasca, L, Ferrante, D, Cirese, E, Todaro, Pa, Romanini, C, Spagnuolo, L, Lanzone, A, Donadio, C, Fabiani, M, Baldaccini, E, Votano, S, Serra, Gb, Bellardini, P, Massacesi, L, Donini, G, Genazzani, Ra, Scarselli, G, Curiel, P, DE LEO, V, Melani, A, D'Ancona, Vl, Giarre, G, DI GIOIA, E, Ciccarelli, P, Sarti, Cd, Balsotti, G, Pupita, P, Mincigrucci, M, Spadafora, A, Santeufemia, G, D'Andrea, A, Chiantera, A, Montemagno, U, Staiano, S, Arienzo, R, Pastore, Ar, Tamburrino, A, Colacurci, A, Izzo, S, Zumpano, N, Pascarella, A, DE SILVIO MG, DI PRISCO, L, Lauda, N, Sorrentino, O, Agrimi, C, Casarella, G, Pisaturo, G, Senatore, G, Ruccia, G, Fasolino, A, Tropea, P, Stigliano, Cm, Giannice, C, Vadala, P, Coco, A, Lombardo, R, Barese, G, Masciari, G, Pirillo, P, Gioffre, T, Ferruccio, C, Agostinelli, D, Tonti, Gc, Scopelliti, A, Schonauer, S, Bongiovanni, F, Tinelli, F, Poddi, Er, Scarpello, F, Colonna, L, Fischetti, G, Doria, R, Trombetta, G, Cocca, Eb, Carone, D, Nocera, F, Giambanco, V, Giannola, C, Graziano, R, Mezzatesta, M, Vegna, G, Giannone, G, Palumbo, G, Cancellieri, Francesco, Mondo, A, Cordopatri, A, Carrubba, M, Mazzola, V, Ettore, G, D'Asta, S, DI LIBERTO, P, Massacesi, A, DE ALOYSIO, P, Ognissanti, F, Gambacciani, A, Graziottin, A, Baldi, C, Colacurci, N, Parazzini, F, Chatenoud, L, and Chiaffarino, F.

Published
2001

35. Determinants of hysterectomy and oophorectomy in women attending menopause clinics in Italy

Author

DE ALOYSIO, D, DI DONATO, P, Giulini, Na, Modena, B, Cicchetti, G, Comitini, G, Gentile, G, Cristiani, P, Careccia, A, Esposito, E, Gigli, C, Mandruzzato, G, Petraglia, F, Bertelli, F, DEL FRATE, G, Garofalo, S, Marino, L, Costa, Mr, Quaranta, S, Bossi, Cm, Amantea, P, Omodei, U, Vaccari, M, Luerti, M, Repetti, F, Zandonini, G, Raspagliesi, F, Dolci, F, Zacchi, V, Bennici, S, Polizzotti, G, Bottino, S, Raffaelli, F, Minervini, C, Colombo, D, Belloni, C, Viani, A, Cecchini, G, Winkler, S, Samaja, Ba, Pasinetti, E, Penotti, M, Malanetto, C, Massobrio, M, Campagnoli, C, Dolfin, G, Tartaglino, P, Mossotto, D, Pesando, P, Pacilli, L, Rattazzi, Pd, Arisi, E, Gamper, M, Salvatores, D, Bocchin, E, Stellin, G, Meli, G, Azzini, V, Tirozzi, F, Buoso, G, Fraioli, R, Marsoni, V, Cetera, C, Sposetti, R, Bellati, U, Angeloni, C, Buonerba, M, Garzarelli, S, Santilli, C, Mucci, M, DI NISIO, Q, Falasca, L, Ferrante, D, Cirese, E, Todaro, Pa, Romanini, C, Spagnuolo, L, Lanzone, A, Donadio, C, Fabiani, M, Baldaccini, E, Votano, S, Serra, Gb, Bellardini, P, Massacesi, L, Donini, G, Genazzani, Ra, Scarselli, G, Curiel, P, DE LEO, V, Melani, A, D'Ancona, Vl, Giarre, G, DI GIOIA, E, Ciccarelli, P, Sarti, Cd, Balsotti, G, Pupita, P, Mincigrucci, M, Spadafora, A, Santeufemia, G, D'Andrea, A, Chiantera, A, Montemagno, U, Staiano, S, Arienzo, R, Pastore, Ar, Tamburrino, A, Colacurci, A, Izzo, S, Zumpano, N, Pascarella, A, DE SILVIO MG, DI PRISCO, L, Lauda, N, Sorrentino, O, Agrimi, C, Casarella, G, Pisaturo, G, Senatore, G, Ruccia, G, Fasolino, A, Tropea, P, Stigliano, Cm, Giannice, C, Vadala, P, Coco, A, Lombardo, R, Barese, G, Masciari, G, Pirillo, P, Gioffre, T, Ferruccio, C, Agostinelli, D, Tonti, Gc, Scopelliti, A, Schonauer, S, Bongiovanni, F, Tinelli, F, Poddi, Er, Scarpello, F, Colonna, L, Fischetti, G, Doria, R, Trombetta, G, Cocca, Eb, Carone, D, Nocera, F, Giambanco, V, Giannola, C, Graziano, R, Mezzatesta, M, Vegna, G, Giannone, G, Palumbo, G, Cancellieri, Francesco, Mondo, A, Cordopatri, A, Carrubba, M, Mazzola, V, Ettore, G, D'Asta, S, DI LIBERTO, P, Angeloni, D'Andrea, Stigliano, Arienzo, Donato, Di, Giulini, Gigli, Ricci, Marino, Luerti, Donini, Dolfin, Poddi, Santeufemia, Nocera, Melani, Messini, Mincigrucci, Salvatores, Bocchin, Massacesi, A, DE ALOYSIO, P, Ognissanti, F, Gambacciani, A, Graziottin, A, Baldi, C, Parazzini, F, Chatenoud, L, and Chiaffarino, F.

Published
2000

36. P062 SIUrO-PRIAS-ITA project: Three year experience on active surveillance

Author

Alvisi, M.F., primary, Magnani, T., additional, Rancati, T., additional, Conti, G., additional, Gallucci, M., additional, Papalia, R., additional, Martorana, G., additional, Diazzi, D., additional, Sanseverino, R., additional, Napodano, G., additional, Graziotti, P., additional, Taverna, G., additional, Proietti, S., additional, Tanello, M., additional, Frego, E., additional, Turci, A., additional, Cicchetti, G., additional, Bollito, E., additional, Colecchia, M., additional, Fiorentino, M., additional, Montironi, R., additional, Patriarca, C., additional, Sentinelli, S., additional, Bangma, C.H., additional, and Valdagni, R., additional

Published
2013
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45. Actin and phosphoinositide binding by the ActA protein of the bacterial pathogen Listeria monocytogenes.

Author

Cicchetti, G, Maurer, P, Wagener, P, and Kocks, C

Abstract

The surface protein ActA of the pathogenic bacterium Listeria monocytogenes induces actin-driven movement of bacteria in the cytoplasm of infected host cells and serves as a model for actin-based motility in general. We generated and purified soluble recombinant fragments of ActA and assessed their ability to interact with the acidic phospholipids phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, both implicated in the regulation of actin polymerization. Purified ActA consisted of biologically active, elongated molecules with an alpha-helix and beta-sheet content of 11 and 32%, respectively. In the presence of either phosphatidylinositol 4,5-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate, but not phosphatidylcholine, ActA molecules underwent a structural change that raised the alpha-helix content to 19% and lowered the beta-sheet content to 27%. Co-sedimentation experiments with phosphatidylcholine vesicles containing different acidic phospholipids demonstrated that ActA binds preferentially to D-3 phosphoinositides. The D-3 phosphoinositide binding activity was mapped to a small subregion in the N-terminal domain of ActA. This subregion comprised 19 amino acids and showed homology to cecropins. In addition, we found that amino acids 33 to 74 of ActA mediated actin binding by the whole, folded ActA molecule. These findings shed new light on ActA function.

Published
1999

47. Premature ovarian failure: Frequency and risk factors among women attending a network of menopause clinics in Italy

Author

Parazzini, F., Aloysio, D., Di Donato, P., Giulini, N. A., Bacchi Modena, A., Cicchetti, G., Comitini, G., Gentile, G., Cristiani, P., Careccia, A., Esposito, E., Gualdi, F., Golinelli, S., Berga-Mini, E., Masellis, G., Rastelli, S., Gigli, C., Elia, A., Marchesoni, D., Sticotti, F., Del Frate, G., Zompicchiatti, C., Marino, L., Costa, M. R., Pinto, P., Dodero, D., Storace, A., Spinelli, G., Quaranta, S., Bossi, C. M., Ollago, A., Omodei, U., Vaccari, M., Luerti, M., Repetti, F., Zandonini, G., Raspagliesi, F., Dolci, F., Gambarino, G., Pasquale, B., Polizzotti, G., Borsellino, G., Alpi-Nelli, P., Natale, N., Colombo, D., Belloni, C., Viani, A., Cecchini, G., Vinci, G. W., Samaja, B. A., Pasinetti, E., Penotti, M., Ognissanti, F., Pesando, P., Malanetto, C., Gallo, M., Dolfin, G., Tartaglino, P., Mossotto, D., Pistoni, A., Tarani, A., Rattazzi, P. D., Rossaro, D., Campanella, M., Arisi, E., Gamper, M., Salvatores, D., Bocchin, E., Stellin, G., Meli, G., Azzini, V., Tirozzi, F., Buoso, G., Fraioli, R., Mar-Soni, V., Cetera, C., Sposetti, R., Candiotto, E., Pignalosa, R., Lino Del Pup, Bellati, U., Angeloni, C., Buonerba, M., Garzarelli, S., Santilli, C., Mucci, M., Di Nisio, Q., Cappa, F., Pierangeli, I., Cordone, A., Falasca, L., Ferrante, D., Serra, G. B., Cirese, E., Todaro, P. A., Romanini, C., Spagnuolo, L., Lanzone, A., and Donadio, C.

48. General and medical factors associated with hormone replacement therapy among women attending menopause clinics in Italy

Author

Aloysio, D., Di Donato, P., Giulini, N. A., Modena, B., Cicchetti, G., Comitini, G., Gentile, G., Cristiani, P., Careccia, A., Esposito, E., Gigli, C., Mandruzzato, G., Petraglia, F., Bertelli, F., Del Frate, G., Garofalo, S., Marino, L., Costa, M. R., Qaranta, S., Bossi, C. M., Amantea, P., Omodei, U., Vaccari, M., Luerti, M., Repetti, F., Zandonini, G., Raspagliesi, F., Dolci, F., Zacchi, V., Bennici, S., Polizzotti, G., Bottino, S., Raffaelli, F., Minervini, C., Colombo, D., Belloni, C., Viani, A., Cecchini, G., Winkler, S., Samaja, B. A., Pasinetti, E., Penotti, M., Malanetto, C., Massobrio, M., Campagnoli, C., Dolfin, G., Tartaglino, P., Mossotto, D., Pesando, P., Pacilli, L., Rattazzi, P. D., Arisi, E., Gamper, M., Salvatores, D., Bocchin, E., Stellin, G., Meli, G., Azzini, V., Tirozzi, F., Buoso, G., Fraioli, R., Marsoni, V., Cetera, C., Sposetti, R., Bellati, U., Angeloni, C., Buonerba, M., Garzarelli, S., Santilli, C., Mucci, M., Di Nisio, Q., Falasca, L., Ferrante, D., Cirese, E., Todaro, P. A., Romanini, C., Spagnuolo, L., Lanzone, A., Donadio, C., Fabiani, M., Baldaccini, E., Votano, S., Serra, G. B., Bellardini, P., Massacesi, L., Donini, G., Genazzani, R. A., Scarselli, G., Curiel, P., Vincenzo De Leo, Melani, A., Levi D Ancona, V., Giarrè, G., Di Gioia, E., Ciccarelli, P., Donati Sarti, C., Balsotti, G., Pupita, P., and Parazzini, F.

49. An unusual lung involvement in scleroderma: lipoid pneumonia

Author

Verardi, L., Calandriello, L., Lorenzis, E., Natalello, G., Gigante, L., Cicchetti, G., Larici, A. R., Gremese, E., D Agostino, M. A., and Silvia Bosello

Subjects
Settore MED/16 - REUMATOLOGIA, Rheumatology, Immunology, Humans, Immunology and Allergy, INGLESE, Tomography, X-Ray Computed, Lung, Pneumonia, Lipid

50. Risk factors for genital prolapse in non-hysterectomized women around menopause - Results from a large cross-sectional study in menopausal clinics in Italy

Author

Aloysio, D., Di Donato, P., Giulini, Na, Modena, B., Cicchetti, G., Comitini, G., Gentile, G., Cristiani, P., Careccia, A., Esposito, E., Gigli, C., Mandruzzato, G., Petraglia, F., Bertelli, F., Del Frate, G., Garofalo, S., Marino, L., Costa, MR, Quaranta, S., Bossi, Cm, Amantea, P., Omodei, U., Vaccari, M., Luerti, M., Repetti, F., Zandonini, G., Raspagliesi, F., Dolci, F., Zacchi, V., Bennici, S., Polizzotti, G., Bottino, S., Raffaelli, F., Minervini, C., Colombo, D., Belloni, C., Viani, A., Cecchini, G., Winkler, S., Samaja, Ba, Pasinetti, E., Penotti, M., Malanetto, C., Massobrio, M., Campagnoli, C., Dolfin, G., Tartaglino, P., Mossotto, D., Pesando, P., Pacilli, L., Rattazzi, Pd, Arisi, E., Gamper, M., Salvatores, D., Bocchin, E., Stellin, G., Meli, G., Azzini, V., Tirozzi, F., Buoso, G., Fraioli, R., Marsoni, V., Cetera, C., Sposetti, R., Bellati, U., Angeloni, C., Buonerba, M., Garzarelli, S., Santilli, C., Mucci, M., Di Nisio, Q., Falasca, L., Ferrante, D., Cirese, E., Todaro, Pa, Romanini, C., Spagnuolo, L., Lanzone, A., Donadio, C., Fabiani, M., Baldaccini, E., Votano, S., Serra, Gb, Bellardini, P., Massacesi, L., Donini, G., Genazzani, Ra, Scarselli, G., Curiel, P., Leo, V., Melani, A., D Ancona, Vl, Giarre, G., Di Gioia, E., Ciccarelli, P., Sarti, Cd, Balsotti, G., Pupita, P., Mincigrucci, M., Spadafora, A., Santeufemia, G., D Andrea, A., Chiantera, A., Montemagno, U., Staiano, S., Arienzo, R., Pastore, Ar, Tamburrino, A., Colacurci, A., Izzo, S., Zumpano, N., Pascarella, A., Silvio, Mg, Di Prisco, L., Lauda, N., Sorrentino, O., Agrimi, C., Casarella, G., Pisaturo, G., Senatore, G., Ruccia, G., Fasolino, A., Tropea, P., Stigliano, Cm, Giannice, C., Vadala, P., Coco, A., Lombardo, R., Barese, G., Masciari, G., Pirillo, P., Gioffre, T., Ferruccio, C., Agostinelli, D., Tonti, Gc, Scopelliti, A., Schonauer, S., Bongiovanni, F., Tinelli, F., Poddi, Er, Scarpello, F., Colonna, L., Fischetti, G., Doria, R., Trombetta, G., Cocca, Eb, Carone, D., Nocera, F., Giambanco, V., Giannola, C., Graziano, R., Mezatesta, M., Vegna, G., Giannone, G., Palumbo, G., Cancellieri, F., Mondo, A., Cordopatri, A., Carrubba, M., Mazzola, V., Ettore, G., D Asta, S., Di Liberto, P., Massacesi, A., Aloysio, P., Ognissanti, F., Gambacciani, A., Graziottin, A., Baldi, C., Parazzini, F., Chatenoud, L., and Francesca Chiaffarino

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