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140 results on '"Cicchetti, Alessandro"'

1. A Computational Model of the Tumor Microenvironment Applied to Fractionated Radiotherapy

Author

Possenti, Luca, Gallo, Andrea, Vitullo, Piermario, Cicchetti, Alessandro, Rancati, Tiziana, Costantino, Maria Laura, Zunino, Paolo, Castro, Carlos, Editor-in-Chief, Formaggia, Luca, Editor-in-Chief, Groppi, Maria, Series Editor, Larson, Mats G., Series Editor, Lopez Fernandez, Maria, Series Editor, Morales de Luna, Tomás, Series Editor, Pareschi, Lorenzo, Series Editor, Vázquez-Cendón, Elena, Series Editor, Zunino, Paolo, Series Editor, Linninger, Andreas, editor, and Mardal, Kent-Andre, editor

Published
2024
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2. Intestinal microbiota composition is predictive of radiotherapy-induced acute gastrointestinal toxicity in prostate cancer patients

Author

Iacovacci, Jacopo, Serafini, Mara Serena, Avuzzi, Barbara, Badenchini, Fabio, Cicchetti, Alessandro, Devecchi, Andrea, Dispinzieri, Michela, Doldi, Valentina, Giandini, Tommaso, Gioscio, Eliana, Mancinelli, Elisa, Noris Chiorda, Barbara, Orlandi, Ester, Palorini, Federica, Possenti, Luca, Reis Ferreira, Miguel, Villa, Sergio, Zaffaroni, Nadia, De Cecco, Loris, Valdagni, Riccardo, and Rancati, Tiziana

Published
2024
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3. Pelvic bone marrow dose-volume predictors of late lymphopenia following pelvic lymph node radiation therapy for prostate cancer

Author

Pavarini, Maddalena, Alborghetti, Lisa, Aimonetto, Stefania, Maggio, Angelo, Landoni, Valeria, Ferrari, Paolo, Bianculli, Antonella, Petrucci, Edoardo, Cicchetti, Alessandro, Farina, Bruno, Ubeira-Gabellini, Maria Giulia, Salmoiraghi, Paolo, Moretti, Eugenia, Avuzzi, Barbara, Giandini, Tommaso, Munoz, Fernando, Magli, Alessandro, Sanguineti, Giuseppe, Magdalena Waskiewicz, Justyna, Rago, Luciana, Cante, Domenico, Girelli, Giuseppe, Vavassori, Vittorio, Di Muzio, Nadia Gisella, Rancati, Tiziana, Cozzarini, Cesare, and Fiorino, Claudio

Published
2024
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7. Validation of prediction models for radiation-induced late rectal bleeding: Evidence from a large pooled population of prostate cancer patients

Author

Cicchetti, Alessandro, Fiorino, Claudio, Ebert, Martin A., Iacovacci, Jacopo, Kennedy, Angel, Joseph, David J., Denham, James W., Vavassori, Vittorio, Fellin, Gianni, Cozzarini, Cesare, Esposti, Claudio Degli, Gabriele, Pietro, Munoz, Fernando, Avuzzi, Barbara, Valdagni, Riccardo, and Rancati, Tiziana

Published
2023
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10. REQUITE: A prospective multicentre cohort study of patients undergoing radiotherapy for breast, lung or prostate cancer

Author

Lievens, Yolande, van Eijkeren, Marc, Vandecasteele, Katrien, Elhamin, Elhaseen, Ost, Piet, Fonteyne, Valérie, Swimberghe, Martijn, Deseyne, Pieter, De Neve, Wilfried, Duprez, Fréderic, Mareel, Marcus, Monten, Chris, Van Greveling, Annick, Vercauteren, Tom, Paelinck, Leen, Defraene, Gilles, Aerts, Rita, Arredouani, Soumia, Lambrecht, Maarten, Vanneste, Ben, Draghici, Roxana, Giordano, Frank, Herskind, Carsten, Veldwijk, Marlon, Helmbold, Irmgard, Giesche, Ulrich, Stegmaier, Petra, Weiß, Christian, Blaschke, Thomas, Neu, Burkhard, Lozza, Laura, Avuzzi, Barbara, Morlino, Sara, Sangalli, Claudia, Franceschini, Marzia, Rodriguez-Lage, Belina, Fernández-Tajes, Juan, Fuentes-Rios, Olivia, Domínguez-Rios, Isabel, Fajardo-Paneque, Irene, Sosa-Fajardo, Paloma, Torrado-Moya, Laura, Ramos-Albiac, Mónica, Giraldo, Alexandra, Altabas, Manolo, Piqué-Leiva, Bibiana, García-Relancio, David, Seoane-Ramallo, Alejandro, Lavers, Samuel, Wright, Simon, Dobbelaere, Hannah, Appleton, Donna, Kaushik, Monika, Kenny, Frances, Khout, Hazem, Krupa, Jaroslaw, Lambert, Kelly V., Pilgrim, Simon, Shokuhi, Sheila, Valassiadou, Kalliope, Aznar-Garcia, Luis, Boiangui, Ion, Kancherla, Kiran, Kent, Christopher, Sampson, Kufre, Osman, Ahmed, Sridhar, Thiagarajan, Vasanthan, Subramaniam, Faivre-Finn, Corinne, Harrop, Victoria, Keni, Manjusha, Foweraker, Karen, Pascoe, Abigail, Esler, Claire, Stock, Richard, Green, Sheryl, Golchin, Ava, Li, William, Seibold, Petra, Webb, Adam, Aguado-Barrera, Miguel E., Azria, David, Bourgier, Celine, Brengues, Muriel, Briers, Erik, Bultijnck, Renée, Calvo-Crespo, Patricia, Carballo, Ana, Choudhury, Ananya, Cicchetti, Alessandro, Claßen, Johannes, Delmastro, Elena, Dunning, Alison M., Elliott, Rebecca M., Fachal, Laura, Farcy-Jacquet, Marie-Pierre, Gabriele, Pietro, Garibaldi, Elisabetta, Gómez-Caamaño, Antonio, Gutiérrez-Enríquez, Sara, Higginson, Daniel S., Johnson, Kerstie, Lobato-Busto, Ramón, Mollà, Meritxell, Müller, Anusha, Payne, Debbie, Peleteiro, Paula, Post, Giselle, Rancati, Tiziana, Rattay, Tim, Reyes, Victoria, Rosenstein, Barry S., De Ruysscher, Dirk, De Santis, Maria Carmen, Schäfer, Jörg, Schnabel, Thomas, Sperk, Elena, Symonds, R. Paul, Stobart, Hilary, Taboada-Valladares, Begoña, Talbot, Christopher J., Valdagni, Riccardo, Vega, Ana, Veldeman, Liv, Ward, Tim, Weißenberger, Christian, West, Catharine M.L., and Chang-Claude, Jenny

Published
2019
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11. Development of a Ready-to-Use Graphical Tool Based on Artificial Neural Network Classification: Application for the Prediction of Late Fecal Incontinence After Prostate Cancer Radiation Therapy

Author

Carrara, Mauro, Massari, Eleonora, Cicchetti, Alessandro, Giandini, Tommaso, Avuzzi, Barbara, Palorini, Federica, Stucchi, Claudio, Fellin, Giovanni, Gabriele, Pietro, Vavassori, Vittorio, Degli Esposti, Claudio, Cozzarini, Cesare, Pignoli, Emanuele, Fiorino, Claudio, Rancati, Tiziana, and Valdagni, Riccardo

Published
2018
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14. 2516: NTCP model of acute toxicity after whole breast irradiation: training and extended validation.

Author

Cicchetti, Alessandro, Vincenzi, Monica, Castriconi, Roberta, Mangili, Paola, Fodor, Andrei, Gabellini, Maria Giulia Ubeira, Chiara, Anna, Deantoni, Chiara, Midulla, Martina, Mori, Martina, Pasetti, Marcella, Palazzo, Gabriele, Tummineri, Roberta, Torrisi, Miriam, Rancati, Tiziana, Vecchio, Antonella del, Di Muzio, Nadia G, and Fiorino, Claudio

Subjects
*IRRADIATION
Published
2024
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17. Comparing Performances of Predictive Models of Toxicity after Radiotherapy for Breast Cancer Using Different Machine Learning Approaches.

Author

Ubeira-Gabellini, Maria Giulia, Mori, Martina, Palazzo, Gabriele, Cicchetti, Alessandro, Mangili, Paola, Pavarini, Maddalena, Rancati, Tiziana, Fodor, Andrei, del Vecchio, Antonella, Di Muzio, Nadia Gisella, and Fiorino, Claudio

Subjects
PREDICTIVE tests, DATABASE management, DATA analysis, RECEIVER operating characteristic curves, RESEARCH funding, RADIATION injuries, BREAST tumors, LOGISTIC regression analysis, TREATMENT effectiveness, RADIATION dosimetry, DESCRIPTIVE statistics, STATISTICS, MACHINE learning
Abstract

Simple Summary: Studies comparing performances of machine learning (ML) methods in building predictive models of toxicity in RT are rare. Thanks to the availability of a large cohort (n = 1314) of breast cancer patients homogeneously treated with tangential fields, different ML approaches could be compared. This work shows how more complex models typically achieve higher performances. At the same time, for this test case, the importance is given mainly by a few variables, and toxicity can be predicted by simpler models with similar performances. The availability of more individually characterizing features (here partially missing) is expected to have a likely much higher impact than the choice of the best-performing ML/DL approach. Purpose. Different ML models were compared to predict toxicity in RT on a large cohort (n = 1314). Methods. The endpoint was RTOG G2/G3 acute toxicity, resulting in 204/1314 patients with the event. The dataset, including 25 clinical, anatomical, and dosimetric features, was split into 984 for training and 330 for internal tests. The dataset was standardized; features with a high p-value at univariate LR and with Spearman ρ > 0.8 were excluded; synthesized data of the minority were generated to compensate for class imbalance. Twelve ML methods were considered. Model optimization and sequential backward selection were run to choose the best models with a parsimonious feature number. Finally, feature importance was derived for every model. Results. The model's performance was compared on a training–test dataset over different metrics: the best performance model was LightGBM. Logistic regression with three variables (LR3) selected via bootstrapping showed performances similar to the best-performing models. The AUC of test data is slightly above 0.65 for the best models (highest value: 0.662 with LightGBM). Conclusions. No model performed the best for all metrics: more complex ML models had better performances; however, models with just three features showed performances comparable to the best models using many (n = 13–19) features. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Curative Carbon Ion Radiotherapy In A Head And Neck Mucosal Melanoma Series: Facing The Future Within Multidisciplinarity

Author

Ronchi, Sara, primary, Cicchetti, Alessandro, additional, Bonora, Maria, additional, Ingargiola, Rossana, additional, Maria Camarda, Anna, additional, Russo, Stefania, additional, Imparato, Sara, additional, Castelnuovo, Paolo, additional, Pasquini, Ernesto, additional, Nicolai, Piero, additional, Ansarin, Mohssen, additional, Del Vecchio, Michele, additional, Benazzo, Marco, additional, Orlandi, Ester, additional, and Vischioni, Barbara, additional

Published
2023
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21. Role of pretreatment 18F-FDG PET/CT parameters in predicting outcome of non-endemic EBV DNA-related nasopharyngeal cancer (NPC) patients treated with IMRT and chemotherapy

Author

Alessi, Alessandra, Lorenzoni, Alice, Cavallo, Anna, Padovano, Barbara, Iacovelli, Nicola Alessandro, Bossi, Paolo, Alfieri, Salvatore, Serafini, Gianluca, Colombo, Carlotta Benedetta, Cicchetti, Alessandro, Mira, Marta, Licitra, Lisa, Fallai, Carlo, Crippa, Flavio, and Orlandi, Ester

Published
2019
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22. 2287: Bone marrow dose-volume predictors of late lymphopenia after pelvic lymph node irradiation for PCa

Author

Pavarini, Maddalena, Alborghetti, Lisa, Aimonetto, Stefania, Maggio, Angelo, Landoni, Valeria, Ferrari, Paolo, Bianculli, Antonella, Petrucci, Edoardo, Cicchetti, Alessandro, Farina, Bruno, Salmoiraghi, Paolo, Moretti, Eugenia, Cazzulo, Elena, Carillo, Viviana, Munoz, Fernando, Magli, Alessandro, Sanguineti, Giuseppe, Waskiewicz, Justyna M., Rago, Luciana, Cante, Domenico, Girelli, Giuseppe, Rancati, Tiziana, Di Muzio, Nadia G, Cozzarini, Cesare, and Fiorino, Claudio

Published
2024
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23. 1568: Toward multi-institutional Knowledge-Based benchmark for right and left whole breast irradiation

Author

Tudda, Alessia, Castriconi, Roberta, Placidi, Lorenzo, Cagni, Elisabetta, Cicchetti, Alessandro, Dusi, Francesca, Guernieri, Marika, Anna, Ianiro, Landoni, Valeria, Malatesta, Tiziana, Mazzilli, Aldo, Meffe, Guenda, Moretti, Eugenia, Oliviero, Caterina, Benecchi, Giovanna, Guidasci, Giulia Rambaldi, Rancati, Tiziana, Scaggion, Alessandro, Trojani, Valeria, Vecchio, Antonella del, and Claudio, Fiorino

Published
2024
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24. 1378: Genetically-based analysis of dose surface maps for assessing toxicity post-RT: an innovative method

Author

Gioscio, Eliana, Massi, Michela Carlotta, Franco, Nicola Rares, Seibold, Petra, Avuzzi, Barbara, Cicchetti, Alessandro, Rosenstein, Barry, Azria, David, Choudhury, Ananya, De Ruysscher, Dirk, Lambrecht, Maarten, Sperk, Elena, Talbot, Christopher J., Vega, Ana, Veldeman, Liv, Webb, Adam, Zunino, Paolo, Paganoni, Anna Maria, Ieva, Francesca, Manzoni, Andrea, Kerns, Sarah L., Dunning, Alison, Chang-Claude, Jenny, West, Catharine M.L., and Rancati, Tiziana

Published
2024
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25. Stomach and duodenum dose–volume constraints for locally advanced pancreatic cancer patients treated in 15 fractions in combination with chemotherapy

Author

Broggi, Sara, primary, Passoni, Paolo, additional, Tiberio, Paolo, additional, Cicchetti, Alessandro, additional, Cattaneo, Giovanni Mauro, additional, Longobardi, Barbara, additional, Mori, Martina, additional, Reni, Michele, additional, Slim, Najla, additional, Del Vecchio, Antonella, additional, Di Muzio, Nadia G., additional, and Fiorino, Claudio, additional

Published
2023
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26. HIGH-PERFORMANCE CELLULAR RADIOSENSITIVITY ASSAY COMBINED TO A POLYGENIC SCORE TO PREDICT LATE POST RADIOTHERAPY OVERREACTION IN CANCER PROSTATE PATIENTS: A PROOF OF CONCEPT

Author

Perreira, Sandrine, primary, Avuzzi, Barbara, additional, Duclos, Mirlande, additional, Berthel, Elise, additional, Chiorda, Barbara Noris, additional, Badenchini, Fabio, additional, Andreoli, Laura, additional, La Rocca, Eliana, additional, Giandini, Tommaso, additional, Cicchetti, Alessandro, additional, Valdagni, Riccardo, additional, and Rancati, Tiziana, additional

Published
2022
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28. TRANSFERABILITY OF KNOWLEDGE BASED (KB) PLAN PREDICTION MODELS FOR RIGHT-WHOLE BREAST IRRADIATION (R-WBI)

Author

Tudda, Alessia, primary, Castriconi, Roberta, additional, Benecchi, Giovanna, additional, Cagni, Elisabetta, additional, Cicchetti, Alessandro, additional, Dusi, Francesca, additional, Esposito, Piergiorgio, additional, Guidasci, Giulia Rambaldi, additional, Guernieri, Marika, additional, Ianiro, Anna, additional, Landoni, Valeria, additional, Mazzilli, Aldo, additional, Moretti, Eugenia, additional, Oliviero, Caterina, additional, Placidi, Lorenzo, additional, Rancati, Tiziana, additional, Trojani, Valeria, additional, Scaggion, Alessandro, additional, and Fiorino, Claudio, additional

Published
2022
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29. Treatment time and circadian genotype interact to influence radiotherapy side-effects. A prospective European validation study using the REQUITE cohort

Author

Webb, Adam J, Harper, Emily, Rattay, Tim, Aguado-Barrera, Miguel E, Azria, David, Bourgier, Celine, Brengues, Muriel, Briers, Erik, Bultijnck, Renée, Chang-Claude, Jenny, Choudhury, Ananya, Cicchetti, Alessandro, De Ruysscher, Dirk, De Santis, Maria Carmen, Dunning, Alison M, Elliott, Rebecca M, Fachal, Laura, Gómez-Caamaño, Antonio, Gutiérrez-Enríquez, Sara, Johnson, Kerstie, Lobato-Busto, Ramón, Kerns, Sarah L, Post, Giselle, Rancati, Tiziana, Reyes, Victoria, Rosenstein, Barry S, Seibold, Petra, Seoane, Alejandro, Sosa-Fajardo, Paloma, Sperk, Elena, Taboada-Valladares, Begoña, Valdagni, Riccardo, Vega, Ana, Veldeman, Liv, Ward, Tim, West, Catharine M, Symonds, R Paul, Talbot, Christopher J, REQUITE Consortium, Webb, Adam J [0000-0002-6699-0479], and Apollo - University of Cambridge Repository

Subjects
Breast cancer, Radiotherapy, Genotype, Circadian rhythm, FOS: Biological sciences, Genetics, ras Proteins, Humans, Period Circadian Proteins, Prospective Studies, Atrophy, Radiation Injuries
Abstract

BACKGROUND: Circadian rhythm impacts broad biological processes, including response to cancer treatment. Evidence conflicts on whether treatment time affects risk of radiotherapy side-effects, likely because of differing time analyses and target tissues. We previously showed interactive effects of time and genotypes of circadian genes on late toxicity after breast radiotherapy and aimed to validate those results in a multi-centre cohort. METHODS: Clinical and genotype data from 1690 REQUITE breast cancer patients were used with erythema (acute; n=340) and breast atrophy (two years post-radiotherapy; n=514) as primary endpoints. Local datetimes per fraction were converted into solar times as predictors. Genetic chronotype markers were included in logistic regressions to identify primary endpoint predictors. FINDINGS: Significant predictors for erythema included BMI, radiation dose and PER3 genotype (OR 1.27(95%CI 1.03-1.56); P < 0.03). Effect of treatment time effect on acute toxicity was inconclusive, with no interaction between time and genotype. For late toxicity (breast atrophy), predictors included BMI, radiation dose, surgery type, treatment time and SNPs in CLOCK (OR 0.62 (95%CI 0.4-0.9); P < 0.01), PER3 (OR 0.65 (95%CI 0.44-0.97); P < 0.04) and RASD1 (OR 0.56 (95%CI 0.35-0.89); P < 0.02). There was a statistically significant interaction between time and genotypes of circadian rhythm genes (CLOCK OR 1.13 (95%CI 1.03-1.23), P < 0.01; PER3 OR 1.1 (95%CI 1.01-1.2), P < 0.04; RASD1 OR 1.15 (95%CI 1.04-1.28), P < 0.008), with peak time for toxicity determined by genotype. INTERPRETATION: Late atrophy can be mitigated by selecting optimal treatment time according to circadian genotypes (e.g. treat PER3 rs2087947C/C genotypes in mornings; T/T in afternoons). We predict triple-homozygous patients (14%) reduce chance of atrophy from 70% to 33% by treating in mornings as opposed to mid-afternoon. Future clinical trials could stratify patients treated at optimal times compared to those scheduled normally. FUNDING: EU-FP7.

Published
2022
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30. Patient-Factors Influencing the 2-Year Trajectory of Mental and Physical Health in Prostate Cancer Patients

Author

Cicchetti, Alessandro, primary, Noale, Marianna, additional, Dordoni, Paola, additional, Noris Chiorda, Barbara, additional, De Luca, Letizia, additional, Bellardita, Lara, additional, Montironi, Rodolfo, additional, Bertoni, Filippo, additional, Bassi, Pierfrancesco, additional, Schiavina, Riccardo, additional, Gacci, Mauro, additional, Serni, Sergio, additional, Sessa, Francesco, additional, Maruzzo, Marco, additional, Maggi, Stefania, additional, and Valdagni, Riccardo, additional

Published
2022
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31. High weekly integral dose and larger fraction size increase risk of fatigue and worsening of functional outcomes following radiotherapy for localized prostate cancer

Author

Joseph, Nuradh, primary, Cicchetti, Alessandro, additional, McWilliam, Alan, additional, Webb, Adam, additional, Seibold, Petra, additional, Fiorino, Claudio, additional, Cozzarini, Cesare, additional, Veldeman, Liv, additional, Bultijnck, Renée, additional, Fonteyne, Valérie, additional, Talbot, Christopher J., additional, Symonds, Paul R., additional, Johnson, Kerstie, additional, Rattay, Tim, additional, Lambrecht, Maarten, additional, Haustermans, Karin, additional, De Meerleer, Gert, additional, Elliott, Rebecca M., additional, Sperk, Elena, additional, Herskind, Carsten, additional, Veldwijk, Marlon, additional, Avuzzi, Barbara, additional, Giandini, Tommaso, additional, Valdagni, Riccardo, additional, Azria, David, additional, Jacquet, Marie-Pierre Farcy, additional, Charissoux, Marie, additional, Vega, Ana, additional, Aguado-Barrera, Miguel E., additional, Gómez-Caamaño, Antonio, additional, Franco, Pierfrancesco, additional, Garibaldi, Elisabetta, additional, Girelli, Giuseppe, additional, Iotti, Cinzia, additional, Vavassori, Vittotorio, additional, Chang-Claude, Jenny, additional, West, Catharine M. L., additional, Rancati, Tiziana, additional, and Choudhury, Ananya, additional

Published
2022
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32. Treatment time and circadian genotype interact to influence radiotherapy side-effects. A prospective European validation study using the REQUITE cohort

Author

Webb, Adam J., primary, Harper, Emily, additional, Rattay, Tim, additional, Aguado-Barrera, Miguel E., additional, Azria, David, additional, Bourgier, Celine, additional, Brengues, Muriel, additional, Briers, Erik, additional, Bultijnck, Renée, additional, Chang-Claude, Jenny, additional, Choudhury, Ananya, additional, Cicchetti, Alessandro, additional, De Ruysscher, Dirk, additional, De Santis, Maria Carmen, additional, Dunning, Alison M., additional, Elliott, Rebecca M., additional, Fachal, Laura, additional, Gómez-Caamaño, Antonio, additional, Gutiérrez-Enríquez, Sara, additional, Johnson, Kerstie, additional, Lobato-Busto, Ramón, additional, Kerns, Sarah L., additional, Post, Giselle, additional, Rancati, Tiziana, additional, Reyes, Victoria, additional, Rosenstein, Barry S., additional, Seibold, Petra, additional, Seoane, Alejandro, additional, Sosa-Fajardo, Paloma, additional, Sperk, Elena, additional, Taboada-Valladares, Begoña, additional, Valdagni, Riccardo, additional, Vega, Ana, additional, Veldeman, Liv, additional, Ward, Tim, additional, West, Catharine M., additional, Symonds, R. Paul, additional, and Talbot, Christopher J., additional

Published
2022
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33. Treatment time and circadian genotype interact to influence radiotherapy side-effects. A prospective European validation study using the REQUITE cohort

Author

Webb, Adam J., Harper, Emily, Rattay, Tim, Aguado-Barrera, Miguel E., Azria, David, Bourgier, Celine, Brengues, Muriel, Briers, Erik, Bultijnck, Renée, Chang-Claude, Jenny, Choudhury, Ananya, Cicchetti, Alessandro, De Ruysscher, Dirk, De Santis, Maria Carmen, Dunning, Alison M., Elliott, Rebecca M., Fachal, Laura, Gómez-Caamaño, Antonio, Gutiérrez-Enríquez, Sara, Johnson, Kerstie, Lobato-Busto, Ramón, Kerns, Sarah L., Post, Giselle, Rancati, Tiziana, Reyes, Victoria, Rosenstein, Barry S., Seibold, Petra, Seoane, Alejandro, Sosa-Fajardo, Paloma, Sperk, Elena, Taboada-Valladares, Begoña, Valdagni, Riccardo, Vega, Ana, Veldeman, Liv, Ward, Tim, West, Catharine M., Symonds, R. Paul, Talbot, Christopher J., Webb, Adam J., Harper, Emily, Rattay, Tim, Aguado-Barrera, Miguel E., Azria, David, Bourgier, Celine, Brengues, Muriel, Briers, Erik, Bultijnck, Renée, Chang-Claude, Jenny, Choudhury, Ananya, Cicchetti, Alessandro, De Ruysscher, Dirk, De Santis, Maria Carmen, Dunning, Alison M., Elliott, Rebecca M., Fachal, Laura, Gómez-Caamaño, Antonio, Gutiérrez-Enríquez, Sara, Johnson, Kerstie, Lobato-Busto, Ramón, Kerns, Sarah L., Post, Giselle, Rancati, Tiziana, Reyes, Victoria, Rosenstein, Barry S., Seibold, Petra, Seoane, Alejandro, Sosa-Fajardo, Paloma, Sperk, Elena, Taboada-Valladares, Begoña, Valdagni, Riccardo, Vega, Ana, Veldeman, Liv, Ward, Tim, West, Catharine M., Symonds, R. Paul, and Talbot, Christopher J.

Abstract

Background: Circadian rhythm impacts broad biological processes, including response to cancer treatment. Evidence conflicts on whether treatment time affects risk of radiotherapy side-effects, likely because of differing time analyses and target tissues. We previously showed interactive effects of time and genotypes of circadian genes on late toxicity after breast radiotherapy and aimed to validate those results in a multi-centre cohort. Methods: Clinical and genotype data from 1690 REQUITE breast cancer patients were used with erythema (acute; n=340) and breast atrophy (two years post-radiotherapy; n=514) as primary endpoints. Local datetimes per fraction were converted into solar times as predictors. Genetic chronotype markers were included in logistic regressions to identify primary endpoint predictors. Findings: Significant predictors for erythema included BMI, radiation dose and PER3 genotype (OR 1.27(95%CI 1.03-1.56); P < 0.03). Effect of treatment time effect on acute toxicity was inconclusive, with no interaction between time and genotype. For late toxicity (breast atrophy), predictors included BMI, radiation dose, surgery type, treatment time and SNPs in CLOCK (OR 0.62 (95%CI 0.4-0.9); P < 0.01), PER3 (OR 0.65 (95%CI 0.44-0.97); P < 0.04) and RASD1 (OR 0.56 (95%CI 0.35-0.89); P < 0.02). There was a statistically significant interaction between time and genotypes of circadian rhythm genes (CLOCK OR 1.13 (95%CI 1.03-1.23), P < 0.01; PER3 OR 1.1 (95%CI 1.01-1.2), P < 0.04; RASD1 OR 1.15 (95%CI 1.04-1.28), P < 0.008), with peak time for toxicity determined by genotype. Interpretation: Late atrophy can be mitigated by selecting optimal treatment time according to circadian genotypes (e.g. treat PER3 rs2087947C/C genotypes in mornings; T/T in afternoons). We predict triple-homozygous patients (14%) reduce chance of atrophy from 70% to 33% by treating in mornings as opposed to mid-afternoon. Future clinical trials could stratify patients tr

Published
2022

35. Modelling Radiation-Induced Salivary Dysfunction during IMRT and Chemotherapy for Nasopharyngeal Cancer Patients

Author

Cavallo, Anna, primary, Iacovelli, Nicola Alessandro, additional, Facchinetti, Nadia, additional, Rancati, Tiziana, additional, Alfieri, Salvatore, additional, Giandini, Tommaso, additional, Cicchetti, Alessandro, additional, Fallai, Carlo, additional, Ingargiola, Rossana, additional, Licitra, Lisa, additional, Locati, Laura, additional, Cavalieri, Stefano, additional, Pignoli, Emanuele, additional, Romanello, Domenico Attilio, additional, Valdagni, Riccardo, additional, and Orlandi, Ester, additional

Published
2021
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37. Health-related quality of life 24 months after prostate cancer diagnosis: an update from the Pros-IT CNR prospective observational study

Author

Palumbo, Carlotta, Bruni, Alessio, Antonelli, Alessandro, Artibani, Walter, Bassi, Pierfrancesco, Bertoni, Filippo, Borghetti, Paolo, Bracarda, Sergio, Cicchetti, Alessandro, Corvò, Renzo, Gacci, Mauro, Ingrosso, Gianluca, Magrini, Stefano M, Maruzzo, Marco, Mirone, Vincenzo, Montironi, Rodolfo, Muto, Giovanni, Noale, Marianna, Porreca, Angelo, Russi, Elvio, Triggiani, Luca, Tubaro, Andrea, Valdagni, Riccardo, Maggi, Stefania, Conti, Giario N, and Ricardi, Umberto

Subjects
Male, Prostatectomy, Prostatic neoplasms, Quality of life, Patient reported outcomes measure, Radiotherapy, Watchful waiting, Urology, Prostatic Neoplasms, Androgen Antagonists, Humans, Quality of Life, Percutaneous Coronary Intervention, Nephrology
Abstract

This study analyzes patient health-related quality of life (QoL) 24-month after prostate cancer (PCa) diagnosis within the PROState cancer monitoring in ITaly from the National Research Council (Pros-IT CNR) study.Pros-IT CNR is an ongoing, longitudinal and observational study, considering a convenience sample of patients enrolled at PCa diagnosis and followed at 6, 12, 24, 36, 48 and 60 months from the diagnosis. Patients were grouped according to the treatment received: nerve sparing radical prostatectomy (NSRP), non-nerve sparing radical prostatectomy (NNSRP), radiotherapy (RT), RT plus androgen deprivation (RT plus ADT) and active surveillance (AS). QoL was measured through the Italian versions of SF-12 and UCLA-PCI questionnaires at diagnosis and at 6-12 and 24-month. The minimal clinically important difference (MCID) was defined as half a standard deviation of the baseline domain.Overall, 1537 patients were included in the study. The decline in urinary function exceeded the MCID at each timepoint only in the NSRP and NNSRP groups (at 24 months -14.7, P0.001 and -19.7, P0.001, respectively). The decline in bowel function exceeded the MCID only in the RT (-9.1, P=0.02) and RT plus ADT groups at 12 months (-10.3, P=0.001); after 24 months, most patients seem to recover their bowel complaints. The decline in sexual function exceeded the MCID at each timepoint in the NNSRP, NSRP and RT plus ADT groups (at 6 months -28.7, P0.001, -37.8, P0.001, -20.4, P0.001, respectively).Although all the treatments were relatively well-tolerated over the 24 month period following PCa diagnosis, each had a different impact on QoL.

Published
2021

39. A Deep Learning Approach Validates Genetic Risk Factors for Late Toxicity After Prostate Cancer Radiotherapy in a REQUITE Multi-National Cohort

Author

Massi, Michela Carlotta, primary, Gasperoni, Francesca, additional, Ieva, Francesca, additional, Paganoni, Anna Maria, additional, Zunino, Paolo, additional, Manzoni, Andrea, additional, Franco, Nicola Rares, additional, Veldeman, Liv, additional, Ost, Piet, additional, Fonteyne, Valérie, additional, Talbot, Christopher J., additional, Rattay, Tim, additional, Webb, Adam, additional, Symonds, Paul R., additional, Johnson, Kerstie, additional, Lambrecht, Maarten, additional, Haustermans, Karin, additional, De Meerleer, Gert, additional, de Ruysscher, Dirk, additional, Vanneste, Ben, additional, Van Limbergen, Evert, additional, Choudhury, Ananya, additional, Elliott, Rebecca M., additional, Sperk, Elena, additional, Herskind, Carsten, additional, Veldwijk, Marlon R., additional, Avuzzi, Barbara, additional, Giandini, Tommaso, additional, Valdagni, Riccardo, additional, Cicchetti, Alessandro, additional, Azria, David, additional, Jacquet, Marie-Pierre Farcy, additional, Rosenstein, Barry S., additional, Stock, Richard G., additional, Collado, Kayla, additional, Vega, Ana, additional, Aguado-Barrera, Miguel Elías, additional, Calvo, Patricia, additional, Dunning, Alison M., additional, Fachal, Laura, additional, Kerns, Sarah L., additional, Payne, Debbie, additional, Chang-Claude, Jenny, additional, Seibold, Petra, additional, West, Catharine M. L., additional, and Rancati, Tiziana, additional

Published
2020
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40. Role of IMRT/VMAT-Based Dose and Volume Parameters in Predicting 5-Year Local Control and Survival in Nasopharyngeal Cancer Patients

Author

Iacovelli, Nicola Alessandro, primary, Cicchetti, Alessandro, additional, Cavallo, Anna, additional, Alfieri, Salvatore, additional, Locati, Laura, additional, Ivaldi, Eliana, additional, Ingargiola, Rossana, additional, Romanello, Domenico A., additional, Bossi, Paolo, additional, Cavalieri, Stefano, additional, Tenconi, Chiara, additional, Meroni, Silvia, additional, Calareso, Giuseppina, additional, Guzzo, Marco, additional, Piazza, Cesare, additional, Licitra, Lisa, additional, Pignoli, Emanuele, additional, Carlo, Fallai, additional, and Orlandi, Ester, additional

Published
2020
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41. SPOP Deregulation Improves the Radiation Response of Prostate Cancer Models by Impairing DNA Damage Repair

Author

El Bezawy, Rihan, primary, Tripari, Martina, additional, Percio, Stefano, additional, Cicchetti, Alessandro, additional, Tortoreto, Monica, additional, Stucchi, Claudio, additional, Tinelli, Stella, additional, Zuco, Valentina, additional, Doldi, Valentina, additional, Gandellini, Paolo, additional, Valdagni, Riccardo, additional, and Zaffaroni, Nadia, additional

Published
2020
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42. Local dose analysis to predict acute and late urinary toxicities after prostate cancer radiotherapy: Assessment of cohort and method effects

Author

Mylona, Eugenia, primary, Cicchetti, Alessandro, additional, Rancati, Tiziana, additional, Palorini, Federica, additional, Fiorino, Claudio, additional, Supiot, Stephane, additional, Magne, Nicolas, additional, Crehange, Gilles, additional, Valdagni, Riccardo, additional, Acosta, Oscar, additional, and de Crevoisier, Renaud, additional

Published
2020
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43. Health-related quality of life 24 months after prostate cancer diagnosis: an update from the Pros-IT CNR prospective observational study.

Author

PALUMBO, Carlotta, BRUNI, Alessio, ANTONELLI, Alessandro, ARTIBANI, Walter, BASSI, Pierfrancesco, BERTONI, Filippo, BORGHETTI, Paolo, BRACARDA, Sergio, CICCHETTI, Alessandro, CORVÒ, Renzo, GACCI, Mauro, INGROSSO, Gianluca, MAGRINI, Stefano M., MARUZZO, Marco, MIRONE, Vincenzo, MONTIRONI, Rodolfo, MUTO, Giovanni, NOALE, Marianna, PORRECA, Angelo, and RUSSI, Elvio

Published
2022
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44. 207 - TRANSFERABILITY OF KNOWLEDGE BASED (KB) PLAN PREDICTION MODELS FOR RIGHT-WHOLE BREAST IRRADIATION (R-WBI)

Author

Tudda, Alessia, Castriconi, Roberta, Benecchi, Giovanna, Cagni, Elisabetta, Cicchetti, Alessandro, Dusi, Francesca, Esposito, Piergiorgio, Guidasci, Giulia Rambaldi, Guernieri, Marika, Ianiro, Anna, Landoni, Valeria, Mazzilli, Aldo, Moretti, Eugenia, Oliviero, Caterina, Placidi, Lorenzo, Rancati, Tiziana, Trojani, Valeria, Scaggion, Alessandro, and Fiorino, Claudio

Published
2022
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47. REQUITE: A prospective multicentre cohort study of patients undergoing radiotherapy for breast, lung or prostate cancer

Author

Seibold, Petra, primary, Webb, Adam, additional, Aguado-Barrera, Miguel E., additional, Azria, David, additional, Bourgier, Celine, additional, Brengues, Muriel, additional, Briers, Erik, additional, Bultijnck, Renée, additional, Calvo-Crespo, Patricia, additional, Carballo, Ana, additional, Choudhury, Ananya, additional, Cicchetti, Alessandro, additional, Claßen, Johannes, additional, Delmastro, Elena, additional, Dunning, Alison M., additional, Elliott, Rebecca M., additional, Fachal, Laura, additional, Farcy-Jacquet, Marie-Pierre, additional, Gabriele, Pietro, additional, Garibaldi, Elisabetta, additional, Gómez-Caamaño, Antonio, additional, Gutiérrez-Enríquez, Sara, additional, Higginson, Daniel S., additional, Johnson, Kerstie, additional, Lobato-Busto, Ramón, additional, Mollà, Meritxell, additional, Müller, Anusha, additional, Payne, Debbie, additional, Peleteiro, Paula, additional, Post, Giselle, additional, Rancati, Tiziana, additional, Rattay, Tim, additional, Reyes, Victoria, additional, Rosenstein, Barry S., additional, De Ruysscher, Dirk, additional, De Santis, Maria Carmen, additional, Schäfer, Jörg, additional, Schnabel, Thomas, additional, Sperk, Elena, additional, Symonds, R. Paul, additional, Stobart, Hilary, additional, Taboada-Valladares, Begoña, additional, Talbot, Christopher J., additional, Valdagni, Riccardo, additional, Vega, Ana, additional, Veldeman, Liv, additional, Ward, Tim, additional, Weißenberger, Christian, additional, West, Catharine M.L., additional, Chang-Claude, Jenny, additional, Lievens, Yolande, additional, van Eijkeren, Marc, additional, Vandecasteele, Katrien, additional, Elhamin, Elhaseen, additional, Ost, Piet, additional, Fonteyne, Valérie, additional, Swimberghe, Martijn, additional, Deseyne, Pieter, additional, De Neve, Wilfried, additional, Duprez, Fréderic, additional, Mareel, Marcus, additional, Monten, Chris, additional, Van Greveling, Annick, additional, Vercauteren, Tom, additional, Paelinck, Leen, additional, Defraene, Gilles, additional, Aerts, Rita, additional, Arredouani, Soumia, additional, Lambrecht, Maarten, additional, Vanneste, Ben, additional, Draghici, Roxana, additional, Giordano, Frank, additional, Herskind, Carsten, additional, Veldwijk, Marlon, additional, Helmbold, Irmgard, additional, Giesche, Ulrich, additional, Stegmaier, Petra, additional, Weiß, Christian, additional, Blaschke, Thomas, additional, Neu, Burkhard, additional, Lozza, Laura, additional, Avuzzi, Barbara, additional, Morlino, Sara, additional, Sangalli, Claudia, additional, Franceschini, Marzia, additional, Rodriguez-Lage, Belina, additional, Fernández-Tajes, Juan, additional, Fuentes-Rios, Olivia, additional, Domínguez-Rios, Isabel, additional, Fajardo-Paneque, Irene, additional, Sosa-Fajardo, Paloma, additional, Torrado-Moya, Laura, additional, Ramos-Albiac, Mónica, additional, Giraldo, Alexandra, additional, Altabas, Manolo, additional, Piqué-Leiva, Bibiana, additional, García-Relancio, David, additional, Seoane-Ramallo, Alejandro, additional, Lavers, Samuel, additional, Wright, Simon, additional, Dobbelaere, Hannah, additional, Appleton, Donna, additional, Kaushik, Monika, additional, Kenny, Frances, additional, Khout, Hazem, additional, Krupa, Jaroslaw, additional, Lambert, Kelly V., additional, Pilgrim, Simon, additional, Shokuhi, Sheila, additional, Valassiadou, Kalliope, additional, Aznar-Garcia, Luis, additional, Boiangui, Ion, additional, Kancherla, Kiran, additional, Kent, Christopher, additional, Sampson, Kufre, additional, Osman, Ahmed, additional, Sridhar, Thiagarajan, additional, Vasanthan, Subramaniam, additional, Faivre-Finn, Corinne, additional, Harrop, Victoria, additional, Keni, Manjusha, additional, Foweraker, Karen, additional, Pascoe, Abigail, additional, Esler, Claire, additional, Stock, Richard, additional, Green, Sheryl, additional, Golchin, Ava, additional, and Li, William, additional

Published
2019
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50. Role of pretreatment 18F-FDG PET/CT parameters in predicting outcome of non-endemic EBV DNA-related nasopharyngeal cancer (NPC) patients treated with IMRT and chemotherapy

Author

Alessi, Alessandra, primary, Lorenzoni, Alice, additional, Cavallo, Anna, additional, Padovano, Barbara, additional, Iacovelli, Nicola Alessandro, additional, Bossi, Paolo, additional, Alfieri, Salvatore, additional, Serafini, Gianluca, additional, Colombo, Carlotta Benedetta, additional, Cicchetti, Alessandro, additional, Mira, Marta, additional, Licitra, Lisa, additional, Fallai, Carlo, additional, Crippa, Flavio, additional, and Orlandi, Ester, additional

Published
2018
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