Search

Your search keyword '"Ciccarelli, Michele"' showing total 825 results
Start Over Author "Ciccarelli, Michele"
825 results on '"Ciccarelli, Michele"'

2. Effect of sacubitril/valsartan on cardiac remodeling compared with other renin–angiotensin system inhibitors: a difference-in-difference analysis of propensity-score matched samples

Author

Carluccio, Erberto, Dini, Frank L., Correale, Michele, Dattilo, Giuseppe, Ciccarelli, Michele, Vannuccini, Francesca, Sforna, Stefano, Pacileo, Giuseppe, Masarone, Daniele, Scelsi, Laura, Ghio, Stefano, Tocchetti, Carlo Gabriele, Mercurio, Valentina, Brunetti, Natale Daniele, Nodari, Savina, Ambrosio, Giuseppe, and Palazzuoli, Alberto

Published
2024
Full Text
View/download PDF

3. Endothelial microRNAs in INOCA patients with diabetes mellitus

Author

Ferrone, Marco, Ciccarelli, Michele, Varzideh, Fahimeh, Kansakar, Urna, Guerra, Germano, Cerasuolo, Federica Andrea, Buonaiuto, Antonietta, Fiordelisi, Antonella, Venga, Enzo, Esposito, Mafalda, Rainone, Antonio, Ricciardi, Roberto, Del Giudice, Carmine, Minicucci, Fabio, Tesorio, Tullio, Visco, Valeria, Iaccarino, Guido, Gambardella, Jessica, Santulli, Gaetano, and Mone, Pasquale

Published
2024
Full Text
View/download PDF

4. Correction to: Frail hypertensive older adults with prediabetes and chronic kidney disease: insights on organ damage and cognitive performance - preliminary results from the CARYATID study

Author

Santulli, Gaetano, Visco, Valeria, Ciccarelli, Michele, Ferrante, Mario Nicola Vittorio, De Masi, Piero, Pansini, Antonella, Virtuoso, Nicola, Pirone, Armando, Guerra, Germano, Verri, Veronica, Macina, Gaetano, Taurino, Alessandro, Komici, Klara, and Mone, Pasquale

Published
2024
Full Text
View/download PDF

7. The Results of the URRAH (Uric Acid Right for Heart Health) Project: A Focus on Hyperuricemia in Relation to Cardiovascular and Kidney Disease and its Role in Metabolic Dysregulation

Author

Maloberti, Alessandro, Mengozzi, Alessandro, Russo, Elisa, Cicero, Arrigo Francesco Giuseppe, Angeli, Fabio, Agabiti Rosei, Enrico, Barbagallo, Carlo Maria, Bernardino, Bruno, Bombelli, Michele, Cappelli, Federica, Casiglia, Edoardo, Cianci, Rosario, Ciccarelli, Michele, Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D’Elia, Lanfranco, Dell’Oro, Raffaella, Facchetti, Rita, Ferri, Claudio, Galletti, Ferruccio, Giannattasio, Cristina, Gesualdo, Loreto, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Masi, Stefano, Masulli, Maria, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Parati, Gianfranco, Palatini, Paolo, Pauletto, Paolo, Pontremoli, Roberto, Pugliese, Nicola Riccardo, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Salvetti, Massimo, Tikhonoff, Valerie, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Virdis, Agostino, Grassi, Guido, and Borghi, Claudio

Published
2023
Full Text
View/download PDF

8. Physical exercise in hypertensive heart disease: From the differential diagnosis to the complementary role of exercise

Author

Pastore, Maria Concetta, Cavigli, Luna, Olivoni, Gabriele, Morrone, Francesco, Amati, Francesca, Imbalzano, Egidio, Rinaldi, Andrea, Liga, Riccardo, Mattioli, Anna Vittoria, Scicchitano, Pietro, Curcio, Antonio, Barillà, Francesco, Ciccarelli, Michele, Maestrini, Viviana, Perrone Filardi, Pasquale, D'Ascenzi, Flavio, and Cameli, Matteo

Published
2024
Full Text
View/download PDF

11. Infiltrating macrophages amplify doxorubicin-induced cardiac damage: role of catecholamines

Author

Gambardella, Jessica, Santulli, Gaetano, Fiordelisi, Antonella, Cerasuolo, Federica Andrea, Wang, Xujun, Prevete, Nella, Sommella, Eduardo, Avvisato, Roberta, Buonaiuto, Antonietta, Altobelli, Giovanna Giuseppina, Rinaldi, Laura, Chiuso, Francesco, Feliciello, Antonio, Dal Piaz, Fabrizio, Campiglia, Pietro, Ciccarelli, Michele, Morisco, Carmine, Sadoshima, Junichi, Iaccarino, Guido, and Sorriento, Daniela

Published
2023
Full Text
View/download PDF

14. Development and validation of a risk score using complete blood count to predict in-hospital mortality in COVID-19 patients

Author

Liu, Hui, Chen, Jing, Yang, Qin, Lei, Fang, Zhang, Changjiang, Qin, Juan-Juan, Chen, Ze, Zhu, Lihua, Song, Xiaohui, Bai, Liangjie, Huang, Xuewei, Liu, Weifang, Zhou, Feng, Chen, Ming-Ming, Zhao, Yan-Ci, Zhang, Xiao-Jing, She, Zhi-Gang, Xu, Qingbo, Ma, Xinliang, Zhang, Peng, Ji, Yan-Xiao, Zhang, Xin, Yang, Juan, Xie, Jing, Ye, Ping, Azzolini, Elena, Aghemo, Alessio, Ciccarelli, Michele, Condorelli, Gianluigi, Stefanini, Giulio G, Xia, Jiahong, Zhang, Bing-Hong, Yuan, Yufeng, Wei, Xiang, Wang, Yibin, Cai, Jingjing, and Li, Hongliang

Subjects
Prevention, Clinical Research, Good Health and Well Being, Blood Cell Count, COVID-19, Hospital Mortality, Humans, Prognosis, Retrospective Studies, Risk Factors, SARS-CoV-2, complete blood count, latent markov model, mortality, prediction model, risk score
Abstract

BackgroundTo develop a sensitive risk score predicting the risk of mortality in patients with coronavirus disease 2019 (COVID-19) using complete blood count (CBC).MethodsWe performed a retrospective cohort study from a total of 13,138 inpatients with COVID-19 in Hubei, China, and Milan, Italy. Among them, 9,810 patients with ≥2 CBC records from Hubei were assigned to the training cohort. CBC parameters were analyzed as potential predictors for all-cause mortality and were selected by the generalized linear mixed model (GLMM).FindingsFive risk factors were derived to construct a composite score (PAWNN score) using the Cox regression model, including platelet counts, age, white blood cell counts, neutrophil counts, and neutrophil:lymphocyte ratio. The PAWNN score showed good accuracy for predicting mortality in 10-fold cross-validation (AUROCs 0.92-0.93) and subsets with different quartile intervals of follow-up and preexisting diseases. The performance of the score was further validated in 2,949 patients with only 1 CBC record from the Hubei cohort (AUROC 0.97) and 227 patients from the Italian cohort (AUROC 0.80). The latent Markov model (LMM) demonstrated that the PAWNN score has good prediction power for transition probabilities between different latent conditions.ConclusionsThe PAWNN score is a simple and accurate risk assessment tool that can predict the mortality for COVID-19 patients during their entire hospitalization. This tool can assist clinicians in prioritizing medical treatment of COVID-19 patients.FundingThis work was supported by National Key R&D Program of China (2016YFF0101504, 2016YFF0101505, 2020YFC2004702, 2020YFC0845500), the Key R&D Program of Guangdong Province (2020B1111330003), and the medical flight plan of Wuhan University (TFJH2018006).

Published
2021

15. Serum uric acid and left ventricular mass index independently predict cardiovascular mortality: The uric acid right for heart health (URRAH) project

Author

Angeli, Fabio, Barbagallo, Carlo M., Bombelli, Michele, Cianci, Rosario, Ciccarelli, Michele, Cicero, Arrigo F.G., Cirillo, Pietro, Dell'Oro, Raffaella, Medica, Clinica, D'Elia, Lanfranco, Desideri, Giovambattista, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Lippa, Luciano, Masi, Stefano, Masulli, Maria, Nazzaro, Pietro, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Virdis, Agostino, Volpe, Massimo, Muiesan, Maria Lorenza, Agabiti Rosei, Claudia, Paini, Anna, Casiglia, Edoardo, Cirillo, Massimo, Grassi, Guido, Iaccarino, Guido, Mallamaci, Francesca, Maloberti, Alessandro, Mazza, Alberto, Mengozzi, Alessandro, Palatini, Paolo, Parati, Gianfranco, Reboldi, Gianpaolo, Rivasi, Giulia, Russo, Elisa, Salvetti, Massimo, Tikhonoff, Valerie, and Borghi, Claudio

Published
2023
Full Text
View/download PDF

17. Experimental evidence and clinical implications of Warburg effect in the skeletal muscle of Fabry disease

Author

Gambardella, Jessica, Fiordelisi, Antonella, Cerasuolo, Federica Andrea, Buonaiuto, Antonietta, Avvisato, Roberta, Viti, Alessandro, Sommella, Eduardo, Merciai, Fabrizio, Salviati, Emanuela, Campiglia, Pietro, D’Argenio, Valeria, Parisi, Silvia, Bianco, Antonio, Spinelli, Letizia, Di Vaia, Eugenio, Cuocolo, Alberto, Pisani, Antonio, Riccio, Eleonora, Di Risi, Teodolinda, Ciccarelli, Michele, Santulli, Gaetano, Sorriento, Daniela, and Iaccarino, Guido

Published
2023
Full Text
View/download PDF

18. Serum Uric Acid, Hypertriglyceridemia, and Carotid Plaques: A Sub-Analysis of the URic Acid Right for Heart Health (URRAH) Study

Author

Agabiti Rosei, Claudia, primary, Paini, Anna, additional, Buso, Giacomo, additional, Maloberti, Alessandro, additional, Giannattasio, Cristina, additional, Salvetti, Massimo, additional, Casiglia, Edoardo, additional, Tikhonoff, Valerie, additional, Angeli, Fabio, additional, Barbagallo, Carlo Maria, additional, Bombelli, Michele, additional, Cappelli, Federica, additional, Cianci, Rosario, additional, Ciccarelli, Michele, additional, Cicero, Arrigo Francesco Giuseppe, additional, Cirillo, Massimo, additional, Cirillo, Pietro, additional, Dell’Oro, Raffaella, additional, D’Elia, Lanfranco, additional, Desideri, Giovambattista, additional, Ferri, Claudio, additional, Galletti, Ferruccio, additional, Gesualdo, Loreto, additional, Grassi, Guido, additional, Iaccarino, Guido, additional, Lippa, Luciano, additional, Mallamaci, Francesca, additional, Masi, Stefano, additional, Masulli, Maria, additional, Mazza, Alberto, additional, Mengozzi, Alessandro, additional, Nazzaro, Pietro, additional, Palatini, Paolo, additional, Parati, Gianfranco, additional, Pontremoli, Roberto, additional, Quarti-Trevano, Fosca, additional, Rattazzi, Marcello, additional, Reboldi, Gianpaolo, additional, Rivasi, Giulia, additional, Russo, Elisa, additional, Tocci, Giuliano, additional, Ungar, Andrea, additional, Verdecchia, Paolo, additional, Viazzi, Francesca, additional, Volpe, Massimo, additional, Virdis, Agostino, additional, Muiesan, Maria Lorenza, additional, and Borghi, Claudio, additional

Published
2024
Full Text
View/download PDF

19. Mechanisms of myocardial reverse remodelling and its clinical significance: A scientific statement of the ESC Working Group on Myocardial Function

Author

Falcão‐Pires, Inês, primary, Ferreira, Ana Filipa, additional, Trindade, Fábio, additional, Bertrand, Luc, additional, Ciccarelli, Michele, additional, Visco, Valeria, additional, Dawson, Dana, additional, Hamdani, Nazha, additional, Van Laake, Linda W., additional, Lezoualc'h, Frank, additional, Linke, Wolfgang A., additional, Lunde, Ida G, additional, Rainer, Peter P., additional, Abdellatif, Mahmoud, additional, Van der Velden, Jolanda, additional, Cosentino, Nicola, additional, Paldino, Alessia, additional, Pompilio, Giulio, additional, Zacchigna, Serena, additional, Heymans, Stephane, additional, Thum, Thomas, additional, and Tocchetti, Carlo Gabriele, additional

Published
2024
Full Text
View/download PDF

21. Untargeted lipidomics reveals specific lipid profiles in COVID-19 patients with different severity from Campania region (Italy)

Author

Ciccarelli, Michele, Merciai, Fabrizio, Carrizzo, Albino, Sommella, Eduardo, Di Pietro, Paola, Caponigro, Vicky, Salviati, Emanuela, Musella, Simona, Sarno, Veronica di, Rusciano, Mariarosaria, Toni, Anna Laura, Iesu, Paola, Izzo, Carmine, Schettino, Gabriella, Conti, Valeria, Venturini, Eleonora, Vitale, Carolina, Scarpati, Giuliana, Bonadies, Domenico, Rispoli, Antonella, Polverino, Benedetto, Poto, Sergio, Pagliano, Pasquale, Piazza, Ornella, Licastro, Danilo, Vecchione, Carmine, and Campiglia, Pietro

Published
2022
Full Text
View/download PDF

22. A ‘Multiomic’ Approach of Saliva Metabolomics, Microbiota, and Serum Biomarkers to Assess the Need of Hospitalization in Coronavirus Disease 2019

Author

Chiara Pozzi, Riccardo Levi, Daniele Braga, Francesco Carli, Abbass Darwich, Ilaria Spadoni, Bianca Oresta, Carola Conca Dioguardi, Clelia Peano, Leonardo Ubaldi, Giovanni Angelotti, Barbara Bottazzi, Cecilia Garlanda, Antonio Desai, Antonio Voza, Elena Azzolini, Maurizio Cecconi, Alberto Mantovani, Giuseppe Penna, Riccardo Barbieri, Letterio S. Politi, Maria Rescigno, Aghemo Alessio, Anfray Clement, Badalamenti Salvatore, Belgiovine Cristina, Bertocchi Alice, Bombace Sara, Brescia Paola, Calcaterra Francesca, Calvi Michela, Cancellara Assunta, Capucetti Arianna, Carenza Claudia, Carloni Sara, Carnevale Silvia, Cazzetta Valentina, Cecconi Maurizio, Ciccarelli Michele, Coianiz Nicolò, Darwich Abbass, Lleo de Nalda Ana, De Paoli Federica, Di Donato Rachele, Digifico Elisabeth, Durante Barbara, FARINA Floriana Maria, Ferrari Valentina, Fornasa Giulia, Franzese Sara, Gil Gomez Antonio, Giugliano Silvia, Gomes Ana Rita, Lizier Michela, Lo Cascio Antonino, Melacarne Alessia, Mozzarelli Alessandro, My Ilaria, Oresta Bianca, Pasqualini Fabio, Pastò Anna, Pelamatti Erica, Perucchini Chiara, Pozzi Chiara, Rimoldi Valeria, Rimoldi Monica, Scarpa Alice, Selmi Carlo, Silvestri Alessandra, Sironi Marina, Spadoni Ilaria, Spano' Salvatore, Spata Gianmarco, Supino Domenico, Tentorio Paolo, Ummarino Aldo, Valentino Sonia, Voza Antonio, Zaghi Elisa, and Zanon Veronica

Subjects
Metabolome, Microbiota, CHI3L1, COVID-19, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Background and Aims: The SARS-CoV-2 pandemic has overwhelmed the treatment capacity of the health care systems during the highest viral diffusion rate. Patients reaching the emergency department had to be either hospitalized (inpatients) or discharged (outpatients). Still, the decision was taken based on the individual assessment of the actual clinical condition, without specific biomarkers to predict future improvement or deterioration, and discharged patients often returned to the hospital for aggravation of their condition. Here, we have developed a new combined approach of omics to identify factors that could distinguish coronavirus disease 19 (COVID-19) inpatients from outpatients. Methods: Saliva and blood samples were collected over the course of two observational cohort studies. By using machine learning approaches, we compared salivary metabolome of 50 COVID-19 patients with that of 270 healthy individuals having previously been exposed or not to SARS-CoV-2. We then correlated the salivary metabolites that allowed separating COVID-19 inpatients from outpatients with serum biomarkers and salivary microbiota taxa differentially represented in the two groups of patients. Results: We identified nine salivary metabolites that allowed assessing the need of hospitalization. When combined with serum biomarkers, just two salivary metabolites (myo-inositol and 2-pyrrolidineacetic acid) and one serum protein, chitinase 3-like-1 (CHI3L1), were sufficient to separate inpatients from outpatients completely and correlated with modulated microbiota taxa. In particular, we found Corynebacterium 1 to be overrepresented in inpatients, whereas Actinomycetaceae F0332, Candidatus Saccharimonas, and Haemophilus were all underrepresented in the hospitalized population. Conclusion: This is a proof of concept that a combined omic analysis can be used to stratify patients independently from COVID-19.

Published
2022
Full Text
View/download PDF

23. Technological Developments, Exercise Training Programs, and Clinical Outcomes in Cardiac Telerehabilitation in the Last Ten Years: A Systematic Review.

Author

Garofano, Marina, Vecchione, Carmine, Calabrese, Mariaconsiglia, Rusciano, Maria Rosaria, Visco, Valeria, Granata, Giovanni, Carrizzo, Albino, Galasso, Gennaro, Bramanti, Placido, Corallo, Francesco, Izzo, Carmine, Ciccarelli, Michele, and Bramanti, Alessia

Subjects
CARDIOVASCULAR disease related mortality, HEALTH services accessibility, HUMAN services programs, DIFFUSION of innovations, COST effectiveness, EXERCISE therapy, HOSPITAL care, MEDICAL care, TELEREHABILITATION, TREATMENT effectiveness, POPULATION geography, DESCRIPTIVE statistics, SYSTEMATIC reviews, MEDLINE, TECHNOLOGY, ONLINE information services, CORONARY artery disease, CARDIAC rehabilitation
Abstract

Background: Cardiovascular diseases (CVDs) are associated with very high rates of re-hospitalization and mortality worldwide, so the complexity of these pathologies requires frequent access to hospital facilities. The guidelines also emphasize the importance of cardiac rehabilitation (CR) programs, which have demonstrated a favorable effect on outcomes, and cardiac telerehabilitation (CTR) could represent an innovative healthcare delivery model. The aim of our review is to study how technologies used in rehabilitation have changed over time and also to understand what types of rehabilitation programs have been used in telerehabilitation. Methods: We searched randomized controlled trials (RCTs) in three electronic databases, PubMed, Web of Science, and Scopus, from January 2015 to January 2024, using relevant keywords. Initially, 502 articles were found, and 79 duplicates were identified and eliminated with EndNote. Results: In total, 16 RCTs fulfilled the pre-defined criteria, which were analyzed in our systematic review. The results showed that after CTR, there was a significant improvement in main outcome measures, as well as in relation to technological advances. Conclusions: Moreover, compared to center-based rehabilitation, CTR can offer further advantages, with better cost-effectiveness, the breakdown of geographical barriers, and the improvement of access to treatment for the female population, which is traditionally more socially committed. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

24. Prediabetes Increases the Risk of Frailty in Prefrail Older Adults With Hypertension: Beneficial Effects of Metformin.

Author

Santulli, Gaetano, Visco, Valeria, Varzideh, Fahimeh, Guerra, Germano, Kansakar, Urna, Gasperi, Maurizio, Marro, Anna, Wilson, Scott, Vittorio Ferrante, Mario Nicola, Pansini, Antonella, Pirone, Armando, Di Lorenzo, Francesco, Tartaglia, Domenico, Iaccarino, Guido, Macina, Gaetano, Agyapong, Esther Densu, Forzano, Imma, Jankauskas, Stanislovas S., Komici, Klara, and Ciccarelli, Michele

Abstract

BACKGROUND: Prediabetes has garnered increasing attention due to its association with cardiovascular conditions, especially hypertension, which heightens the risk of prefrailty and frailty among older individuals. METHODS: We screened elders with prefrail hypertension from March 2021 to January 2023. We assessed the correlation linking cognitive dysfunction (Montreal Cognitive Assessment score), insulin resistance (triglyceride-to-glucose index), and physical impairment (5-meter gait speed). Then, we measured the risk of developing frailty after a 1-year follow-up period, adjusting the outcome using multivariable Cox regression analysis. We also investigated the impact of administering 500 mg of metformin once daily to a subset of frail subjects for an additional 6 months. RESULTS: We assessed the relationship between the triglyceride-to-glucose index and the Montreal Cognitive Assessment score, observing a significant correlation (r, 0.880; P<0.0001). Similarly, we analyzed the association between the triglycerideto-glucose index and 5-meter gait speed, uncovering a significant link between insulin resistance and physical impairment (r, 0.809; P<0.0001). Prediabetes was found to significantly (P<0.0001) elevate the risk of frailty development compared with individuals without prediabetes by the end of the 1-year follow-up, a finding confirmed via multivariable analysis with Cox regression. Furthermore, among the subgroup of subjects who developed frailty, those who received metformin exhibited a significant decrease in frailty levels (P<0.0001). CONCLUSIONS: Insulin resistance and prediabetes play substantial roles in the development of cognitive and physical impairments, highlighting their importance in managing hypertension, even before the onset of frank diabetes. Metformin, a well-established drug for the treatment of diabetes, has shown favorable effects in mitigating frailty. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

26. SIRT1 pharmacological activation rescues vascular dysfunction and prevents thrombosis in MTHFR deficiency

Author

Carrizzo, Albino, Iside, Concetta, Nebbioso, Angela, Carafa, Vincenzo, Damato, Antonio, Sciarretta, Sebastiano, Frati, Giacomo, Di Nonno, Flavio, Valenti, Valentina, Ciccarelli, Michele, Venturini, Eleonora, Scioli, Mariarosaria, Di Pietro, Paola, Bucci, Tommaso, Giudice, Valentina, Storto, Marianna, Serio, Bianca, Puca, Annibale Alessandro, Giugliano, Giuseppe, Trimarco, Valentina, Izzo, Raffaele, Trimarco, Bruno, Selleri, Carmine, Altucci, Lucia, and Vecchione, Carmine

Published
2022
Full Text
View/download PDF

28. Serum Uric Acid/Serum Creatinine Ratio and Cardiovascular Mortality in Diabetic Individuals—The Uric Acid Right for Heart Health (URRAH) Project

Author

D’Elia, Lanfranco, primary, Masulli, Maria, additional, Cirillo, Pietro, additional, Virdis, Agostino, additional, Casiglia, Edoardo, additional, Tikhonoff, Valerie, additional, Angeli, Fabio, additional, Barbagallo, Carlo Maria, additional, Bombelli, Michele, additional, Cappelli, Federica, additional, Cianci, Rosario, additional, Ciccarelli, Michele, additional, Cicero, Arrigo F. G., additional, Cirillo, Massimo, additional, Dell’Oro, Raffaella, additional, Desideri, Giovambattista, additional, Ferri, Claudio, additional, Gesualdo, Loreto, additional, Giannattasio, Cristina, additional, Grassi, Guido, additional, Iaccarino, Guido, additional, Lippa, Luciano, additional, Mallamaci, Francesca, additional, Maloberti, Alessandro, additional, Masi, Stefano, additional, Mazza, Alberto, additional, Mengozzi, Alessandro, additional, Muiesan, Maria Lorenza, additional, Nazzaro, Pietro, additional, Palatini, Paolo, additional, Parati, Gianfranco, additional, Pontremoli, Roberto, additional, Quarti-Trevano, Fosca, additional, Rattazzi, Marcello, additional, Reboldi, Gianpaolo, additional, Rivasi, Giulia, additional, Russo, Elisa, additional, Salvetti, Massimo, additional, Tocci, Giuliano, additional, Ungar, Andrea, additional, Verdecchia, Paolo, additional, Viazzi, Francesca, additional, Volpe, Massimo, additional, Borghi, Claudio, additional, and Galletti, Ferruccio, additional

Published
2024
Full Text
View/download PDF

29. Triglyceride-glucose Index and Mortality in a Large Regional-based Italian Database (URRAH Project)

Author

D’Elia, Lanfranco, primary, Masulli, Maria, additional, Virdis, Agostino, additional, Casiglia, Edoardo, additional, Tikhonoff, Valerie, additional, Angeli, Fabio, additional, Barbagallo, Carlo Maria, additional, Bombelli, Michele, additional, Cappelli, Federica, additional, Cianci, Rosario, additional, Ciccarelli, Michele, additional, Cicero, Arrigo F G, additional, Cirillo, Massimo, additional, Cirillo, Pietro, additional, Dell’Oro, Raffaella, additional, Desideri, Giovambattista, additional, Ferri, Claudio, additional, Gesualdo, Loreto, additional, Giannattasio, Cristina, additional, Grassi, Guido, additional, Iaccarino, Guido, additional, Lippa, Luciano, additional, Mallamaci, Francesca, additional, Maloberti, Alessandro, additional, Masi, Stefano, additional, Mazza, Alberto, additional, Mengozzi, Alessandro, additional, Muiesan, Maria Lorenza, additional, Nazzaro, Pietro, additional, Palatini, Paolo, additional, Parati, Gianfranco, additional, Pontremoli, Roberto, additional, Quarti-Trevano, Fosca, additional, Rattazzi, Marcello, additional, Reboldi, Gianpaolo, additional, Rivasi, Giulia, additional, Russo, Elisa, additional, Salvetti, Massimo, additional, Tocci, Giuliano, additional, Ungar, Andrea, additional, Verdecchia, Paolo, additional, Viazzi, Francesca, additional, Volpe, Massimo, additional, Borghi, Claudio, additional, and Galletti, Ferruccio, additional

Published
2024
Full Text
View/download PDF

34. Sarilumab in patients admitted to hospital with severe or critical COVID-19: a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Bazzalo, Ignacio J., Casas, Marcelo M., Nuñez, Sebastián A., Pere, Yael, Ibarrola, Carlos M., Solis Aramayo, Marco A., Cuesta, Maria C., Duarte, Andrea E., Gutierrez Fernandez, Pablo M., Iannantuono, Maria A., Miyazaki, Erica A., Silvio, Javier P., Scublinsky, Dario G., Bales, Alessandra, Catarino, Daniela, Fiss, Elie, Mohrbacher, Sara, Sato, Victor, Baylao, Antonio, Cavalcante, Adilson, Correa, Francini, de Andrade, Celso A., Furtado, Juvencio, Ribeiro Filho, Nelson, Telles, Valéria, Trevelin, Leopoldo T., Vipich, Ricardo, Boldo, Rodrigo, Borges, Paula, Lobo, Suzana, Luckemeyer, Graziela, Machado, Luana, Alves, Maysa B., Iglessias, Ana C., Lago, Marianna M., Santos, Daniel W., Chapdelaine, Hugo, Falcone, Emilia L., Jamal, Rahima, Luong, Me-Linh, Durand, Madeleine, Doucet, Stephane, Carrier, François-Martin, Coburn, Bryan A., Del Sorbo, Lorenzo, Walmsley, Sharon L., Belga, Sara, Chen, Luke Y., Mah, Allison D., Steiner, Theodore, Wright, Alissa J., Hajek, J., Adhikari, Neill, Fowler, Robert A., Daneman, Nick, Khwaja, Kosar A., Shahin, Jason, Gonzalez, Carolina, Silva, Rafael, Lindh, Marcelo, Maluenda, Gabriel, Fernandez, Patricia, Oyonarte, Maite, Lasso, Martin, Boyer, Alexandre, Bronnimann, Didier, Bui, Hoang-Nam, Cazanave, Charles, Chaussade, Helene, Desclaux, Arnaud, Ducours, Mailys, Duvignaud, Alexandre, Malvy, Denis, Martin, Lisa, Neau, Didier, Nguyen, Duc, Pistone, Thierry, Soubrane-Wirth, Gaetane, Leitao, Julie, Allavena, Clotilde, Biron, Charlotte, Bouchez, Sabelline, Gaborit, Benjamin, Gregoire, Antoine, Le Turnier, Paul, Lecompte, Anne-Sophie, Lecomte, Raphael, Lefebvre, Maeva, Raffi, Francois, Boutoille, David, Morineau, Pascale H., Guéry, Romain, Chatelus, Emmanuel, Dumoussaud, Nathalie, Felten, Renaud, Luca, Florina, Goichot, Bernard, Schneider, Francis, Taquet, Marie-Caroline, Groh, Matthieu, Roumier, Mathilde, Neuville, Mathilde, Bachelard, Antoine, Isernia, Valentina, Lescure, F-Xavier, Phung, Bao-Chau, Rachline, Anne, Sautereau, Aurelie, Vallois, Dorothee, Bleher, Yves, Boucher, Delphine, Coudon, Clémentine, Esnault, Jean, Guimard, Thomas, Leautez-Nainville, Sophie, Merrien, Dominique, Morrier, Marine, Motte-Vincent, Pauline, Gabeff, Romain, Leclerc, Hélène, Cozic, Céline, Decours, Romain, Février, Ronan, Colin, Gwenhael, Abgrall, Sophie, Vignes, Dorothee, Sterpu, Raluca, Kuellmar, Mira, Meersch-Dini, Melanie, Weiss, Raphael, Zarbock, Alexander, Antony, Christiane, Berger, Marc, Brenner, Thorsten, Taube, Christian, Herbstreit, Frank, Dolff, Sebastian, Konik, Margarethe, Schmidt, Karsten, Zettler, Markus, Witzke, Oliver, Boell, Boris, Garcia Borrega, Jorge, Koehler, Philipp, Zander, Thomas, Dusse, Fabian, Al-Sawaf, Othman, Köhler, Philipp, Eichenauer, Dennis, Kochanek, Matthias, Shimabukuro-Vornhagen, Alexander, Mellinghoff, Sibylle, Claßen, Annika, Heger, Jan-Michel, Meyer-Schwickerath, Charlotte, Liedgens, Paul, Heindel, Katrin, Belkin, Ana, Biber, Asaf, Gilboa, Mayan, Levy, Itzchak, Litachevsky, Vladislav, Rahav, Galia, Finesod Wiedner, Anat, Zilberman-Daniels, Tal, Oster, Yonatan, Strahilevitz, Jacob, Sviri, Sigal, Baldissera, Elena M., Campochiaro, Corrado, Cavalli, Giulio, Dagna, Lorenzo, De Luca, Giacomo, Della Torre, Emanuel, Tomelleri, Alessandro, Bernasconi De Luca, Davide, Capetti, Amedeo F., Coen, Massimo, Cossu, Maria V., Galli, Massimo, Giacomelli, Andrea, Gubertini, Guido A., Rusconi, Stefano, Burastero, Giulia J., Digaetano, Margherita, Guaraldi, Giovanni, Meschiari, Marianna, Mussini, Cristina, Puzzolante, Cinzia, Volpi, Sara, Aiello, Marina, Ariani, Alarico, Chetta, Alfredo A., Frizzelli, Annalisa, Ticinesi, Andrea, Tuttolomondo, Domenico, Aliberti, Stefano, Blasi, Francesco B., Di Pasquale, Marta F., Misuraca, Sofia, Pilocane, Tommaso, Simonetta, Edoardo, Aghelmo, Alessio M., Angelini, Claudio, Brunetta, Enrico, Canonica, Giorgio W., Ciccarelli, Michele, Dal Farra, Sara, De Santis, Maria, Ferri, Sebastian, Folci, Marco, Guidelli, Giacomo M., Heffler, Enrico M., Loiacono, Ferdinando, Malipiero, Giacomo, Paoletti, Giovanni, Pedale, Rosa, Puggioni, Francesca A., Racca, Francesca, Zumbo, Aurora, Satou, Morihiko, Honda, Hitoshi, Lisun, Tatyana, Protsenko, Denis, Rubtsov, Nikolay, Beloglazova, Irina, Fomina, Daria, Lysenko, Mariana, Serdotetskova, Sofia, Firstov, Vitali, Gordeev, Ivan, Kokorin, Ilia, Komissarova, Ksenia, Lapochkina, Nina, Luchinkina, Elena, Malimon, Valentin, Mamedguseyinova, Sevinch, Polubatonova, Ksenia, Suvorova, Natalia, Arribas, Jose, Borobia Perez, Alberto M., de la Calle Prieto, Fernando, Figueira, Juan Carlos, Motejano Sanchez, Rocio, Mora-Rillo, Marta, Prados Sanchez, Concepcion, Queiruga Parada, Javier, Fernandez Arnalich, Francisco, Guerro Barrientos, Maria, Bendala Estrada, Alejandro, Caballero Marcos, Aranzazu, Garcia Leoni, Maria E., García-Martínez, Rita, Collado, Ana María, Munoz Garcia, Patricia, Torres do Rego, Ana, Villalba García, María V., Burrillo, Almudena, Valerio Minero, Maricela, Gijon Vidaurreta, Paloma, Infante Herrero, Sonsoles, Velilla, Elena, Machado, Marina, Olmedo, Maria, Pinilla, Blanca, Almirante Gragera, Benito, Cañas Ruano, Maria de la Esperanza, Contreras Medina, Sofia, Cortés Herrera, Alejandro, Falcó Ferrer, Vicenç, Ferrer Roca, Ricard, Nuvials Casals, Xavier, Ribera Pascuet, Esteve, Suanzes Diez, Paula, Rebollo Castro, Pedro, Garcia Alcaide, Felipe, Soriano, Alejandro, Oliver Caldes, Aina, González Cordón, Ana, Cardozo, Celia, De la Mora Cañizo, Lorena, Pena López, Romina, Chamorro, Sandra, Crespillo-Andujar, Clara, Escudero Sanchez, Rosa, Fortún-Abete, Jesús, Monge-Maillo, Begoña, Moreno Zamora, Ana, Norman, Francesca, Sanchez Conde, Matilde, Serrano Villar, Sergio, Vizcarra, Pilar, Lescure, François-Xavier, Fowler, Robert A, Lazar, Jennifer Sloane, Shi, Genming, Wung, Peter, Patel, Naimish, and Hagino, Owen

Published
2021
Full Text
View/download PDF

37. Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19

Author

Brunetta, Enrico, Folci, Marco, Bottazzi, Barbara, De Santis, Maria, Gritti, Giuseppe, Protti, Alessandro, Mapelli, Sarah N., Bonovas, Stefanos, Piovani, Daniele, Leone, Roberto, My, Ilaria, Zanon, Veronica, Spata, Gianmarco, Bacci, Monica, Supino, Domenico, Carnevale, Silvia, Sironi, Marina, Davoudian, Sadaf, Peano, Clelia, Landi, Francesco, Di Marco, Fabiano, Raimondi, Federico, Gianatti, Andrea, Angelini, Claudio, Rambaldi, Alessandro, Garlanda, Cecilia, Ciccarelli, Michele, Cecconi, Maurizio, and Mantovani, Alberto

Published
2021
Full Text
View/download PDF

41. The association of uric acid with mortality modifies at old age: data from the uric acid right for heart health (URRAH) study

Author

Ungar, Andrea, Rivasi, Giulia, Di Bari, Mauro, Virdis, Agostino, Casiglia, Edoardo, Masi, Stefano, Mengozzi, Alessandro, Barbagallo, Carlo M., Bombelli, Michele, Bruno, Bernardino, Cicero, Arrigo F.G., Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D’elia, Lanfranco, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Iaccarino, Guido, Ciccarelli, Michele, Lippa, Luciano, Mallamaci, Francesca, Maloberti, Alessandro, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Salvetti, Massimo, Tikhonoff, Valérie, Tocci, Giuliano, Cianci, Rosario, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Grassi, Guido, and Borghi, Claudio

Published
2021
Full Text
View/download PDF

43. Anti-Inflammation and Anti-Oxidation: The Key to Unlocking the Cardiovascular Potential of SGLT2 Inhibitors and GLP1 Receptor Agonists

Author

Myasoedova, Veronika A., primary, Bozzi, Michele, additional, Valerio, Vincenza, additional, Moschetta, Donato, additional, Massaiu, Ilaria, additional, Rusconi, Valentina, additional, Di Napoli, Daniele, additional, Ciccarelli, Michele, additional, Parisi, Valentina, additional, Agostoni, Piergiuseppe, additional, Genovese, Stefano, additional, and Poggio, Paolo, additional

Published
2023
Full Text
View/download PDF

44. Acute heart failure: mechanisms and pre-clinical models—a Scientific Statement of the ESC Working Group on Myocardial Function

Author

Ciccarelli, Michele, primary, Pires, Inês Falcão, additional, Bauersachs, Johann, additional, Bertrand, Luc, additional, Beauloye, Christophe, additional, Dawson, Dana, additional, Hamdani, Nazha, additional, Hilfiker-Kleiner, Denise, additional, van Laake, Linda W, additional, Lezoualc’h, Frank, additional, Linke, Wolfgang A, additional, Lunde, Ida G, additional, Rainer, Peter P, additional, Rispoli, Antonella, additional, Visco, Valeria, additional, Carrizzo, Albino, additional, Ferro, Matteo Dal, additional, Stolfo, Davide, additional, van der Velden, Jolanda, additional, Zacchigna, Serena, additional, Heymans, Stephane, additional, Thum, Thomas, additional, and Tocchetti, Carlo Gabriele, additional

Published
2023
Full Text
View/download PDF

47. Serum Uric Acid/Serum Creatinine Ratio and Cardiovascular Mortality in Diabetic Individuals—The Uric Acid Right for Heart Health (URRAH) Project.

Author

D'Elia, Lanfranco, Masulli, Maria, Cirillo, Pietro, Virdis, Agostino, Casiglia, Edoardo, Tikhonoff, Valerie, Angeli, Fabio, Barbagallo, Carlo Maria, Bombelli, Michele, Cappelli, Federica, Cianci, Rosario, Ciccarelli, Michele, Cicero, Arrigo F. G., Cirillo, Massimo, Dell'Oro, Raffaella, Desideri, Giovambattista, Ferri, Claudio, Gesualdo, Loreto, Giannattasio, Cristina, and Grassi, Guido

Subjects
URIC acid, RIGHT to health, CREATININE, KIDNEY physiology, PEOPLE with diabetes, HEART, KIDNEYS
Abstract

Several studies have detected a direct association between serum uric acid (SUA) and cardiovascular (CV) risk. In consideration that SUA largely depends on kidney function, some studies explored the role of the serum creatinine (sCr)-normalized SUA (SUA/sCr) ratio in different settings. Previously, the URRAH (URic acid Right for heArt Health) Study has identified a cut-off value of this index to predict CV mortality at 5.35 Units. Therefore, given that no SUA/sCr ratio threshold for CV risk has been identified for patients with diabetes, we aimed to assess the relationship between this index and CV mortality and to validate this threshold in the URRAH subpopulation with diabetes; the URRAH participants with diabetes were studied (n = 2230). The risk of CV mortality was evaluated by the Kaplan–Meier estimator and Cox multivariate analysis. During a median follow-up of 9.2 years, 380 CV deaths occurred. A non-linear inverse association between baseline SUA/sCr ratio and risk of CV mortality was detected. In the whole sample, SUA/sCr ratio > 5.35 Units was not a significant predictor of CV mortality in diabetic patients. However, after stratification by kidney function, values > 5.35 Units were associated with a significantly higher mortality rate only in normal kidney function, while, in participants with overt kidney dysfunction, values of SUA/sCr ratio > 7.50 Units were associated with higher CV mortality. The SUA/sCr ratio threshold, previously proposed by the URRAH Study Group, is predictive of an increased risk of CV mortality in people with diabetes and preserved kidney function. While, in consideration of the strong association among kidney function, SUA, and CV mortality, a different cut-point was detected for diabetics with impaired kidney function. These data highlight the different predictive roles of SUA (and its interaction with kidney function) in CV risk, pointing out the difference in metabolic- and kidney-dependent SUA levels also in diabetic individuals. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

48. Chronic Kidney Disease with Mineral Bone Disorder and Vascular Calcification: An Overview.

Author

Izzo, Carmine, Secondulfo, Carmine, Bilancio, Giancarlo, Visco, Valeria, Virtuoso, Nicola, Migliarino, Serena, Ciccarelli, Michele, Di Pietro, Paola, La Mura, Lucia, Damato, Antonio, Carrizzo, Albino, and Vecchione, Carmine

Subjects
RENAL osteodystrophy, ARTERIAL calcification, CALCIUM metabolism, PULSE wave analysis, VASCULAR smooth muscle
Abstract

Chronic kidney disease (CKD) is a global health issue with a rising prevalence, affecting 697.5 million people worldwide. It imposes a substantial burden, contributing to 35.8 million disability-adjusted life years (DALYs) and 1.2 million deaths in 2017. The mortality rate for CKD has increased by 41.5% between 1990 and 2017, positioning it as a significant cause of global mortality. CKD is associated with diverse health complications, impacting cardiovascular, neurological, nutritional, and endocrine aspects. One prominent complication is CKD–mineral and bone disorder (MBD), a complex condition involving dysregulation of bone turnover, mineralization, and strength, accompanied by soft tissue and vascular calcification. Alterations in mineral metabolism, including calcium, phosphate, parathyroid hormone (PTH), vitamin D, fibroblast growth factor-23 (FGF-23), and Klotho, play pivotal roles in CKD-MBD. These disturbances, observed early in CKD, contribute to the progression of bone disorders and renal osteodystrophy (ROD). Vascular calcification (VC) is a key component of CKD-MBD, accelerated by CKD. The pathophysiology involves complex processes in vascular smooth muscle cells and the formation of calciprotein particles (CPP). VC is closely linked to cardiovascular events and mortality, emphasizing its prognostic significance. Various serum markers and imaging techniques, including lateral plain X-ray, Kauppila Score, Adragao Score, and pulse wave velocity, aid in VC detection. Additionally, pQCT provides valuable information on arterial calcifications, offering an advantage over traditional scoring systems. CKD poses a substantial global health burden, and its complications, including CKD-MBD and VC, significantly contribute to morbidity and mortality. Understanding the intricate relationships between mineral metabolism, bone disorders, and vascular calcification is crucial for effective diagnosis and therapeutic interventions. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

49. Anti-Inflammation and Anti-Oxidation: The Key to Unlocking the Cardiovascular Potential of SGLT2 Inhibitors and GLP1 Receptor Agonists.

Author

Myasoedova, Veronika A., Bozzi, Michele, Valerio, Vincenza, Moschetta, Donato, Massaiu, Ilaria, Rusconi, Valentina, Di Napoli, Daniele, Ciccarelli, Michele, Parisi, Valentina, Agostoni, Piergiuseppe, Genovese, Stefano, and Poggio, Paolo

Subjects
INSULIN, GLUCAGON-like peptide 1, SODIUM-glucose cotransporter 2 inhibitors, PEPTIDE receptors, TYPE 2 diabetes, HEART metabolism, EPICARDIAL adipose tissue
Abstract

Type 2 diabetes mellitus (T2DM) is a prevalent and complex metabolic disorder associated with various complications, including cardiovascular diseases. Sodium-glucose co-transporter 2 inhibitors (SGLT2i) and glucagon-like peptide 1 receptor agonists (GLP1-RA) have emerged as novel therapeutic agents for T2DM, primarily aiming to reduce blood glucose levels. However, recent investigations have unveiled their multifaceted effects, extending beyond their glucose-lowering effect. SGLT2i operate by inhibiting the SGLT2 receptor in the kidneys, facilitating the excretion of glucose through urine, leading to reduced blood glucose levels, while GLP1-RA mimic the action of the GLP1 hormone, stimulating glucose-dependent insulin secretion from pancreatic islets. Both SGLT2i and GLP1-RA have shown remarkable benefits in reducing major cardiovascular events in patients with and without T2DM. This comprehensive review explores the expanding horizons of SGLT2i and GLP1-RA in improving cardiovascular health. It delves into the latest research, highlighting the effects of these drugs on heart physiology and metabolism. By elucidating their diverse mechanisms of action and emerging evidence, this review aims to recapitulate the potential of SGLT2i and GLP1-RA as therapeutic options for cardiovascular health beyond their traditional role in managing T2DM. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

50. Bridging the gap in the symptomatic heart failure patient journey: insights from the Italian scenario

Author

Ziacchi, Matteo, primary, Spadotto, Alberto, additional, Ghio, Stefano, additional, Pellegrino, Marta, additional, Potena, Luciano, additional, Masarone, Daniele, additional, Merlo, Marco, additional, Stolfo, Davide, additional, Caracciolo, Maria Michela, additional, Inserra, Corinna, additional, Ammirati, Fabrizio, additional, Ciccarelli, Michele, additional, Colivicchi, Furio, additional, Bianchi, Stefano, additional, Patti, Giuseppe, additional, Oliva, Fabrizio, additional, Arcidiacono, Giuseppe, additional, Rordorf, Roberto, additional, Pini, Daniela, additional, Pacileo, Giuseppe, additional, D’Onofrio, Antonio, additional, Forleo, Giovanni Battista, additional, Mariani, Matteo, additional, Adamo, Francesco, additional, Alonzo, Alessandro, additional, Ruzzolini, Matteo, additional, Ghiglieno, Chiara, additional, Cipriani, Manlio, additional, Firetto, Giorgio, additional, Aspromonte, Nadia, additional, Clemenza, Francesco, additional, Maria De Ferrari, Gaetano, additional, Senni, Michele, additional, Grazia Bongiorni, Maria, additional, Tondo, Claudio, additional, Grimaldi, Massimo, additional, Giallauria, Francesco, additional, Rametta, Francesco, additional, Marchese, Procolo, additional, Biffi, Mauro, additional, and Sinagra, Gianfranco, additional

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results