79 results on '"Ciardullo, Av"'
Search Results
2. GPsʼ satisfaction with the doctor–patient encounter: findings from a community-based survey
- Author
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Daghio, MM, Ciardullo, AV, Cadioli, T, Delvecchio, C, Menna, A, Voci, C, Guidetti, P, Magrini, N, and Liberati, A
- Published
- 2003
3. Varicose veins of the lower limbs and venouscapacitance in postmenopausal women: relationship with obesity
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De Michele M, Iannuzzi A, Celentano E, Ciardullo AV, Galasso R, Sacchetti L, Zarrilli F, Bond MG, RUBBA, PAOLO OSVALDO FEDERICO, PANICO, SALVATORE, De Michele, M, Panico, Salvatore, Iannuzzi, A, Celentano, E, Ciardullo, Av, Galasso, R, Sacchetti, L, Zarrilli, F, Bond, Mg, and Rubba, PAOLO OSVALDO FEDERICO
- Published
- 2002
4. The impact of graves' disease and its treatment on handwriting characteristics
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Papi, Giampaolo, Botti, C, Corsello, Salvatore Maria, Ciardullo, Av, Pontecorvi, Alfredo, Hegedüs, L., Corsello, Salvatore Maria (ORCID:0000-0002-4544-7274), Pontecorvi, Alfredo (ORCID:0000-0003-0570-6865), Papi, Giampaolo, Botti, C, Corsello, Salvatore Maria, Ciardullo, Av, Pontecorvi, Alfredo, Hegedüs, L., Corsello, Salvatore Maria (ORCID:0000-0002-4544-7274), and Pontecorvi, Alfredo (ORCID:0000-0003-0570-6865)
- Abstract
Thyroid hormones are crucial for metabolism in all tissues in humans, including the nervous system and muscles, and could thus affect handwriting, which is the synthesis of complex and fine movements. Hyperthyroidism, characterized by symptoms such as tremor and weakness, could affect handwriting, although this has not been studied yet. The aim of this study was to evaluate handwriting characteristics before and after therapy for hyperthyroid Graves' disease (GD).
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- 2014
5. Dietary fiber in the prevention of cardiovascular disease
- Author
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RICCARDI, GABRIELE, Ciardullo AV, Riccardi, Gabriele, and Ciardullo, Av
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Dietary Fiber ,Clinical Trials as Topic ,Cardiovascular Diseases ,Humans - Published
- 1993
6. Association between benign paroxysmal positional vertigo and autoimmune chronic thyroiditis
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Papi, Giampaolo, Corsello, Salvatore Maria, Milite, Mt, Zanni, M, Ciardullo, Av, Donato, Cdi, Pontecorvi, Alfredo, Corsello, Salvatore Maria (ORCID:0000-0002-4544-7274), Pontecorvi, Alfredo (ORCID:0000-0003-0570-6865), Papi, Giampaolo, Corsello, Salvatore Maria, Milite, Mt, Zanni, M, Ciardullo, Av, Donato, Cdi, Pontecorvi, Alfredo, Corsello, Salvatore Maria (ORCID:0000-0002-4544-7274), and Pontecorvi, Alfredo (ORCID:0000-0003-0570-6865)
- Abstract
We describe the association between benign paroxysmal positional vertigo and autoimmune chronic thyroiditis
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- 2009
7. Endogenous sex hormones and carotid atherosclerosis in women partecipating to a population-based study: findings from Progetto Atena
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Panico, S, Sacchetti, L, Ciardullo, Av, Celentano, E, Covetti, G, Pastinese, A, Galasso, R, Zarrilli, F, Intrieri, Mariano, Mercuri, M, and Rubba, P.
- Published
- 1997
8. Estradiolo e indicatori di arteriosclerosi carotidea in un gruppo di donne partecipanti al 'progetto ATENA'
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Panico, S, Sacchetti, L, Celentano, E, Covetti, G, Ciardullo, Av, Pastinese, A, Zarrilli, F, Iannuzzo, G, Intrieri, Mariano, and Mercuri, M.
- Published
- 1997
9. Impacto de una iniciativa de información sanitaria en atención primaria para los ciudadanos
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Ciardullo, AV, primary, Luca, ML de, additional, Brunetti, M, additional, and Daghio, MM, additional
- Published
- 2003
- Full Text
- View/download PDF
10. Association of obesity and central fat distribution with carotid artery wall thickening in middle-aged women.
- Author
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De Michele M, Panico S, Iannuzzi A, Celentano E, Ciardullo AV, Galasso R, Sacchetti L, Zarrilli F, Bond MG, Rubba P, De Michele, Mario, Panico, Salvatore, Iannuzzi, Arcangelo, Celentano, Egidio, Ciardullo, Anna V, Galasso, Rocco, Sacchetti, Lucia, Zarrilli, Federica, Bond, M Gene, and Rubba, Paolo
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- 2002
- Full Text
- View/download PDF
11. Characteristics of some wheat-based foods of the Italian diet in relation to their influence on postprandial glucose metabolism in patients with type 2 diabetes.
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Giacco R, Brighenti F, Parillo M, Capuano M, Ciardullo AV, Rivieccio A, Rivellese AA, and Riccardi G
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- 2001
- Full Text
- View/download PDF
12. Large-scale hormone replacement therapy and life expectancy: results from an international comparison among European and North American populations.
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Panico S, Galasso R, Celentano E, Ciardullo AV, Frova L, Capocaccia R, Trevisan M, and Berrino F
- Abstract
OBJECTIVES: An analysis was performed to determine the risks and benefits of a 10-year hormone replacement therapy regimen that had been applied to all women at 50 years of age in 8 countries. METHODS: Cumulative mortality with and without hormone replacement therapy over 20 years was estimated, with both current and predicted total and disease-specific secular mortality trends and the influence of a generational cohort effect taken into account. RESULTS: In countries with high ischemic heart disease frequency and predictable relative predominance of ischemic heart disease rates over breast cancer rates for the next 20 years, hormone replacement therapy could result in benefits with regard to overall mortality; this advantage decreases in younger-generation cohorts. In countries in which breast cancer mortality predominates over ischemic heart disease in early postmenopause and in which the predictable trends for both diseases reinforce this condition, a negative effect on overall mortality would be observed. In the United States, the effect of large-scale hormone replacement therapy would change over time. CONCLUSIONS: The long-term effect of hormone replacement therapy on life expectancy of postmenopausal women may vary among countries. [ABSTRACT FROM AUTHOR]
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- 2000
- Full Text
- View/download PDF
13. A Molecular Epidemiology Project on Diet and Cancer: The Epic-Italy Prospective Study. Design and Baseline Characteristics of Participants
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Palli, Domenico, Berrino, Franco, Vineis, Paolo, Tumino, Rosario, Panico, Salvatore, Masala, Giovanna, Saieva, Calogero, Salvini, Simonetta, Cerati, Marco, Pala, Valeria, Sieri, Sabina, Frasca, Graziella, Giurdanella, Maria Concetta, Sacerdote, Carlotta, Fiorini, Laura, Celentano, Egidio, Galasso, Rocco, Decarli, Adriano, Krogh, Vittorio, Palli, D, Masala, G, Saieva, C, Salvini, S, Assedi, M, Ceroti, M, Cordopatri, G, Ermini, I, Martinez, M, Tanzini, D, Zacchi, S, Zanna, I, Zappitello, C, Berrino, F, Krogh, V, Sieri, S, Pala, V, Fusconi, E, Tagliabue, G, Bellegotti, M, Evangelista, A, Del Sette, D, Foggetti, C, Vineis, P, Davico, L, Sacerdote, C, Fiorini, L, Veglia, F, Bertinetti, S, Tumino, R, Gafà, L, Frasca, G, Giurdanella, MC, Lauria, C, Martorana, C, Ruggeri, MG, Ruschena, AM, Panico, S, Celentano, E, Galasso, R, Ciardullo, AV, Del Pezzo, M, de Magistris, M Santucci, and Mattiello, A
- Abstract
EPIC-Italy is the Italian section of a larger project known as EPIC (European Prospective Investigation into Cancer and Nutrition), a prospective study on diet and cancer carried out in 10 European countries. In the period 1993-1998, EPIC-Italy completed the recruitment of 47,749 volunteers (15,171 men, 32,578 women, aged 35-65 years) in 4 different areas covered by cancer registries: Varese (12,083 volunteers) and Turin (10,604) in the Northern part of the country; Florence (13,597) and Ragusa (6,403) in Central and Southern Italy, respectively. An associate center in Naples enrolled 5,062 women. Detailed information for each individual volunteer about diet and life-style habits, anthropometric measurements and a blood sample was collected, after signing an informed consent form. A food frequency questionnaire specifically developed for the Italian dietary pattern was tested in a pilot phase. A computerized data base with the dietary and lifestyle information of each participant was completed. Blood samples were processed in the same day of collection, aliquoted (RBC, WBC, serum and plasma) and stored in liquid nitrogen containers. Follow-up procedures were validated and implemented for the identification of newly diagnosed cancer cases. Cancer incidence was related to dietary habits and biochemical markers of food consumption and individual susceptibility in order to test the role of diet-related exposure in the etiology of cancer and its interaction with other environmental or genetic determinants. The comparability of information in a prospective study design is much higher than in other studies. The availability of such a large biological bank linked to individual data on dietary and life-style exposures also provides the unique opportunity of evaluating the role of selected genotypes involved in the metabolism of chemical compounds and DNA repair, potentially related to the risk of cancer, in residents of geographic areas of Italy characterized by specific cancer risk and different dietary patterns. Baseline characteristics of participants are briefly described.
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- 2003
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14. Impact of an educational intervention on breastfeeding.
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Daghio MM, Vezzani MD, and Ciardullo AV
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- 2003
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15. Characteristics of some wheat-based foods of the Italian diet in relation to their influence on postprandial glucose metabolism in patients with type 2 diabetes
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Gabriele Riccardi, Anna V. Ciardullo, M. Parillo, M. Capuano, Angela A. Rivellese, Rosalba Giacco, A. M. Rivieccio, Furio Brighenti, Giacco, R, Brighenti, F, Parillo, M, Capuano, M, Ciardullo, Av, Rivieccio, Am, Rivellese, ANGELA ALBAROSA, and Riccardi, Gabriele
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Blood Glucose ,Male ,food.ingredient ,Starch ,medicine.medical_treatment ,Medicine (miscellaneous) ,Type 2 diabetes ,Biology ,Carbohydrate metabolism ,chemistry.chemical_compound ,food ,Diabetes mellitus ,Diet, Diabetic ,medicine ,Humans ,Insulin ,Food science ,Resistant starch ,Triticum ,Analysis of Variance ,Nutrition and Dietetics ,Hydrolysis ,digestive, oral, and skin physiology ,food and beverages ,Bread ,Middle Aged ,Carbohydrate ,Postprandial Period ,medicine.disease ,Diet ,Postprandial ,Diabetic diet ,Diabetes Mellitus, Type 2 ,Italy ,chemistry ,Digestion ,Female - Abstract
The present study was aimed at evaluating in patients with type 2 diabetes: (1) the glycaemic response to four starchy foods based on wheat, typical of the Italian diet; (2) the importance of some food characteristics in relation to their effects on postprandial glucose response. Seventeen patients with type 2 diabetes (eleven men and six women) participated in the study. All patients consumed, in random order and on alternate days, 50 g available carbohydrate provided by 90 g white bread and, according to a randomised procedure, an equivalent amount of carbohydrate provided by one (n 8) or two (n 9) of three other different test foods (g): pizza 85, potato dumplings 165, hard toasted bread 60. Foods had a similar nutrient composition. Plasma glucose response, measured for 180 min, was significantly lower after the potato dumplings than after white bread at 90 (Pin vitro hydrolysis with α-amylase was about 30 % lower for potato dumplings than for the other foods. However, no differences in the resistant starch content, the rate of diffusion of simple sugars added to a dialysis tube containing the food, and the viscosity of digesta were observed among the test foods. Scanning electron microscopy of potato dumplings showed a compact structure compatible with impaired accessibility of starch to digestive enzymes. In conclusion, carbohydrate-rich foods typical of the Italian diet which are often consumed as an alternative to pasta dishes are not equivalent in terms of metabolic impact in diabetic patients. Due to their low blood glucose response, potato dumplings represent a valid alternative to other starchy foods in the diabetic diet. Food structure plays an important role in determining starch accessibility to digestion, thus influencing the postprandial blood glucose response.
- Published
- 2001
- Full Text
- View/download PDF
16. Menstrual cycle length, serum lipids and lipoproteins in a cohort of Italian Mediterranean women: findings from Progetto ATENA
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Paolo Chiodini, Salvatore Panico, F. Rubba, A.V. Ciardullo, Maria Triassi, Marco Gentile, E. Celentano, Amalia Mattiello, Paolo Rubba, Rocco Galasso, Rubba, F, Mattiello, A, Chiodini, Paolo, Celentano, E, Galasso, R, Ciardullo, Av, Gentile, M, Triassi, M, Rubba, P, Panico, S., Chiodini, P, Triassi, Maria, Rubba, PAOLO OSVALDO FEDERICO, and Panico, Salvatore
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Adult ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,media_common.quotation_subject ,Lipoproteins ,Serum lipids and lipoproteins ,Medicine (miscellaneous) ,Blood lipids ,Disease ,Biology ,Body Mass Index ,Cohort Studies ,Insulin resistance ,Internal medicine ,medicine ,Humans ,Italian Mediterranean women ,Menstrual cycle ,Menstrual cycle length ,Triglycerides ,media_common ,Aged ,Nutrition and Dietetics ,Middle Aged ,medicine.disease ,Lipids ,Endocrinology ,Cardiovascular Diseases ,Cohort ,Female ,Metabolic syndrome ,Cardiology and Cardiovascular Medicine ,Hormone - Abstract
Background and aims Clinical studies suggest that menstrual irregularities are associated with metabolic and hormonal abnormalities, insulin resistance and a hyperestrogenic/hyperandrogenic imbalance, that may influence the risk of cardiovascular disease. Methods and results The association of these abnormalities with the metabolic syndrome suggests that information on lipid patterns at different menstrual cycle length may be of interest in identifying women at higher cardiovascular risk. The association of lipid patterns with menstrual cycle length was evaluated in a cohort of 5062 women participating in the Progetto ATENA Study. Questions were administered to the participants about their cycle lengths at different periods of time over their reproductive life. The period between 20 and 50 years was investigated: normal cycle length was defined as short (≤26 days), medium (between 27 and 29 days) or long (>30 days). Perimenopausal women were excluded and variables adjusted for age, BMI and menopausal status. In 4434 participants serum triglycerides were found to increase with an increased number of days in the menstrual cycle: 106 mg/dl in the short cycle pattern (21–26 days); 113 mg/dl in the medium cycle pattern (27–29 days); and 116 mg/dl in the long cycle pattern (30–31 days), whereas total and LDL cholesterol were found to be higher and HDL was lower in women with longer cycles, but the difference was not statistically significant. The results were very similar when the same adjusted analysis was restricted to a subgroup of 3823 women with a stable cycle length over the fourth and the fifth decade of life. Conclusions These results suggest that cycle length may be a marker of higher cardiovascular risk due to associated metabolic and hormonal patterns.
- Published
- 2008
17. Physical activity in the EPIC-Italy centers
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Rosario Tumino, Calogero Saieva, Franco Berrino, Carlotta Sacerdote, Simonetta Salvini, Melania Assedi, Giovanna Masala, Domenico Palli, Anna V. Ciardullo, Fabrizio Veglia, Valeria Pala, Graziella Frasca, Salvatore Panico, Salvini, S, Saieva, C, Ciardullo, Av, Panico, Salvatore, Masala, G, Assedi, M, Berrino, F, Pala, V, Frasca, G, Tumino, R, Veglia, F, Sacerdote, C, and Palli, D.
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Adult ,Male ,Gerontology ,Work ,Cancer Research ,Physical Exertion ,Population ,Physical activity ,Activity index ,EPIC ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Age Distribution ,Leisure Activities ,0302 clinical medicine ,Neoplasms ,Surveys and Questionnaires ,Humans ,Medicine ,Prospective Studies ,Sex Distribution ,education ,Exercise ,education.field_of_study ,business.industry ,General Medicine ,Middle Aged ,Physical activity level ,European Prospective Investigation into Cancer and Nutrition ,Chronic disease ,Italy ,Oncology ,030220 oncology & carcinogenesis ,Female ,Epic study ,Basal Metabolism ,Energy Metabolism ,business - Abstract
The European Prospective Investigation into Cancer and nutrition offers the opportunity to explore patterns of physical activity in a large series of healthy adults enrolled in the different local cohorts of the Italian section of the European EPIC project. Physical activity is considered one of the means by which chronic disease could be prevented. Subjects in the EPIC study completed a life-style questionnaire, with a section dedicated to the assessment of physical activity at work and during leisure time. Time spent in the various activities was transformed into an index of physical activity (physical activity level, PAL) and an activity index that includes intense activity (PAL; intense activity included). Quintiles of these indexes were computed in order to observe the distribution of subject characteristics according to levels of physical activity. In general, the population was characterized by low levels of physical activity at work, with more than 50% of the sample reporting sedentary occupations. During leisure time, only a small percentage of subjects compensated for the inactivity at work by engaging in energy-consuming activities. In particular, organized fitness activities were reported by a small percentage of people, whereas walking was the most common sort of physical activity. Specific types of activity seemed to characterize subjects in the different areas of the country, reflecting local traditions or specific living situations. Detailed information about physical activity habits, together with a description of other characteristics, could help in designing physical activity promotion programs in different Italian populations and age groups.
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- 2003
18. Association of obesity and central fat distribution with carotid artery wall thickening in middle-aged women
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Federica Zarrilli, M. Gene Bond, Egidio Celentano, Paolo Rubba, Mario De Michele, Arcangelo Iannuzzi, Rocco Galasso, Salvatore Panico, Lucia Sacchetti, Anna V. Ciardullo, DE MICHELE, M., Panico, Salvatore, Iannuzzi, A., Celentano, A., Ciardullo, Av, Galasso, R., Sacchetti, L., Zarrilli, F., Bond, Mg, Rubba, PAOLO OSVALDO FEDERICO, M., DE MICHELE, A., Iannuzzi, E., Celentano, A. V., Ciardullo, R., Galasso, Sacchetti, Lucia, F., Zarrilli, and M. G., Bond
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Blood Glucose ,Blood Pressure ,Body Mass Index ,Cohort Studies ,carotid arteries ,Risk Factors ,Insulin ,Carotid Stenosis ,Prospective Studies ,Prospective cohort study ,Ultrasonography ,Carotid arterie ,Middle Aged ,Adipose Tissue ,Italy ,Atherosclerosi ,Female ,Lipoproteins, HDL ,Tunica Media ,Cardiology and Cardiovascular Medicine ,Cohort study ,Adult ,medicine.medical_specialty ,Carotid Artery, Common ,Internal medicine ,medicine ,Humans ,Women ,Obesity ,Risk factor ,Triglycerides ,Vascular Patency ,Aged ,Advanced and Specialized Nursing ,Vascular disease ,business.industry ,Cholesterol, HDL ,medicine.disease ,Middle age ,Surgery ,Multivariate Analysis ,Etiology ,Body Constitution ,atherosclerosis, carotid arteries, obesity, women ,Neurology (clinical) ,atherosclerosis ,Tunica Intima ,business ,Body mass index - Abstract
Background and Purpose— The association between obesity and atherosclerotic disease is controversial. In the present analysis, we evaluated whether common carotid intima-media thickness (IMT) and area, 2 markers of preclinical atherosclerosis, were increased in obese subjects. Methods— More than 5000 middle-aged women (n=5062; age, 30 to 69 years) living in the area of Naples, Southern Italy, were recruited for a prospective, currently ongoing study on the etiology of cardiovascular disease and cancer in the female population (the Progetto ATENA study). A subsample of 310 participants underwent high-resolution B-mode ultrasound examination, and the IMTs, intima-media areas, and lumen diameters of common carotid arteries were measured with a semiautomated computerized program. Subjects were divided into 3 groups on the basis of the recently published obesity guidelines for body mass index (BMI), a marker of general obesity, and tertiles of waist-to-hip ratio (WHR), a marker of regional obesity. Results— Women with a BMI ≥30 kg/m 2 showed higher systolic and diastolic blood pressures, triglycerides, and fasting glucose and insulin, as well as lower high-density lipoprotein concentrations, than subjects with lower BMI. A gradual increase in common carotid IMT and intima-media area was observed when lean women (0.94±0.01 mm and 19.8±0.5 mm 2 , respectively) were compared with overweight (0.98±0.01 mm and 21.0±0.4 mm 2 ) and obese (1.02±0.02 mm and 22.6±0.8 mm 2 , P 0.85) had adverse risk factor profiles and thicker carotid intima-media complex than those in the first 2 tertiles ( P P Conclusions— The present results indicate a graded and independent association between general and abdominal obesity—reflected by high BMI and WHR—and carotid artery wall thickening in a population of middle-aged women.
- Published
- 2002
19. Varicose veins of the lower limbs and venous capacitance in postmenopausal women: relationship with obesity
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Franco Berrino, Anna Vittoria Ciardullo, Arcangelo Iannuzzi, Cristina Bellati, Salvatore Panico, Paolo Rubba, Egidio Celentano, Vincenzo Cioffi, Gabriella Iannuzzo, Iannuzzi, A., Panico, Salvatore, Ciardullo, Av, Bellati, C., Cioffi, Vincenzo, Iannuzzo, G., Celentano, E., Berrino, F., and Rubba, PAOLO OSVALDO FEDERICO
- Subjects
medicine.medical_specialty ,Gastroenterology ,Body Mass Index ,Varicose Veins ,Sex hormone-binding globulin ,Internal medicine ,Vascular Capacitance ,Varicose veins ,medicine ,Humans ,Plethysmograph ,Obesity ,Risk factor ,Aged ,Leg ,biology ,Vascular disease ,business.industry ,Odds ratio ,Middle Aged ,medicine.disease ,Plethysmography ,Postmenopause ,Endocrinology ,biology.protein ,Female ,Surgery ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Varices ,Body mass index - Abstract
Objective: The purpose of this study was to examine the association between body mass index (BMI), venous capacitance, and clinical evidence of varicose veins after adjustment for sex hormones in postmenopausal women. Methods: This study group of the DIANA (DIet and ANdrogens) project (a randomized controlled trial on the effect of some dietary changes on sex hormone pattern in women with elevated androgenic hormone levels in Italy) was comprised of 104 healthy volunteer postmenopausal women, aged 48 to 65 years. The main outcome measures were physical examination to determine the presence and severity of varicose veins and plethysmographic measurement of lower limb venous capacitance and outflow. Results: Women in the upper quartile of BMI (>30 kg/m 2 ) showed a positive association with clinical evidence of varicose veins (odds ration, 5.8; 95% CI, 1.2 to 28.2) after adjustment for age, estradiol, testosterone, and sex hormone binding globulin. No association was found between BMI and plethysmographic measurements of venous parameters. Conclusion: Obesity is associated with clinical evidence of varicose veins independently from the influence of sex hormones in postmenopausal women and is not associated with venous capacitance. Increased body weight increases the risk of varicose veins. (J Vasc Surg 2002;36:965-8.)
- Published
- 2002
20. High endogenous estradiol is associated with increased venous distensibility and clinical evidence of varicose veins in menopausal women
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Cristina Bellati, Arcangelo Iannuzzi, Gabriella Iannuzzo, Franco Berrino, Anna V. Ciardullo, Paolo Rubba, Vincenzo Cioffi, Sabina Rinaldi, Salvatore Panico, Ciardullo, Av, Panico, Salvatore, Bellati, C, Rubba, PAOLO OSVALDO FEDERICO, Rinaldi, S, Iannuzzi, A, Ciuffi, V, Iannuzzo, G, and Berrino, F.
- Subjects
medicine.medical_specialty ,biology ,business.industry ,Vascular disease ,Physiology ,Odds ratio ,medicine.disease ,Menopause ,Endocrinology ,Sex hormone-binding globulin ,Internal medicine ,Varicose veins ,medicine ,biology.protein ,Plethysmograph ,Surgery ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Varices ,business ,Testosterone - Abstract
Objective: The purpose of this study was to determine if there is an association between elevated sex hormones (ie, serum estradiol, sex hormone binding globulin [SHBG], testosterone) and increased venous distension and clinical evidence of varicose veins in menopausal women. Methods: Participants were 104 healthy volunteer menopausal women, aged 48 to 65 years, who were not undergoing hormonal treatment. Of these 104, 14 were excluded from analyses because their estradiol levels were compatible with a premenopausal condition (4), because they had missing values for insulin concentration (5), and because they did not show up at venous vessel examination (5). Patients underwent a physical examination to determine the presence of varicose veins; a venous strain-gauge plethysmographic examination to compute instrumental measures of venous distensibility; and laboratory analyses of blood so serum testosterone, estradiol, SHBG, glucose, and insulin could be measured. There were also prevalence ratios and odds ratios used to test the presence of an association between biochemical and instrumental variables. Results: Serum levels of estradiol in the upper tertile of the frequency distribution were significantly associated with clinical evidence of varicose veins (prevalence odds ratios 3.6; 95% CI 1.1-11.6) and with increased lower limb venous distensibility (prevalence odds ratios 4.4; 95% CI 1.2-15.5). No association was found for SHBG and testosterone. Conclusions: Our finding that high serum levels of estradiol are associated with clinical evidence of varicose veins and instrumental measurements indicating increased venous distensibility in menopausal women suggests that endogenous estrogens may play a role in the development of this very common venous vessel abnormalities. (J Vasc Surg 2000;32:544-9.)
- Published
- 2000
21. Large-scale hormone replacement therapy and life expectancy: results from an international comparison among European and North American populations
- Author
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Maurizio Trevisan, Franco Berrino, Anna V. Ciardullo, Riccardo Capocaccia, Luisa Frova, Egidio Celentano, Rocco Galasso, Salvatore Panico, Panico, Salvatore, Galasso, R, Celentano, E, Ciardullo, Av, Frova, L, Capocaccia, R, Trevisan, M, and Berrino, F.
- Subjects
medicine.medical_specialty ,Time Factors ,Heart disease ,Breast Neoplasms ,Coronary Disease ,Disease ,Age Distribution ,Life Expectancy ,Predictive Value of Tests ,Risk Factors ,Cause of Death ,Cohort Effect ,Epidemiology ,medicine ,Humans ,Aged ,Vascular disease ,business.industry ,Public health ,Estrogen Replacement Therapy ,Public Health, Environmental and Occupational Health ,Middle Aged ,medicine.disease ,Europe ,Menopause ,Logistic Models ,Transgender hormone therapy ,North America ,Life expectancy ,Female ,business ,Forecasting ,Research Article ,Demography - Abstract
OBJECTIVES: An analysis was performed to determine the risks and benefits of a 10-year hormone replacement therapy regimen that had been applied to all women at 50 years of age in 8 countries. METHODS: Cumulative mortality with and without hormone replacement therapy over 20 years was estimated, with both current and predicted total and disease-specific secular mortality trends and the influence of a generational cohort effect taken into account. RESULTS: In countries with high ischemic heart disease frequency and predictable relative predominance of ischemic heart disease rates over breast cancer rates for the next 20 years, hormone replacement therapy could result in benefits with regard to overall mortality; this advantage decreases in younger-generation cohorts. In countries in which breast cancer mortality predominates over ischemic heart disease in early postmenopause and in which the predictable trends for both diseases reinforce this condition, a negative effect on overall mortality would be observed. In the United States, the effect of large-scale hormone replacement therapy would change over time. CONCLUSIONS: The long-term effect of hormone replacement therapy on life expectancy of postmenopausal women may vary among countries.
- Published
- 2000
22. Does a high-carbohydrate diet have different effects in NIDDM patients treated with diet alone or hypoglycemic drugs?
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A. V. Ciardullo, Rosalba Giacco, Gabriele Riccardi, A.A. Rivellese, M. Parillo, Parillo, M, Giacco, R, Ciardullo, Av, Rivellese, ANGELA ALBAROSA, and Riccardi, Gabriele
- Subjects
Blood Glucose ,medicine.medical_specialty ,Diet therapy ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Glibenclamide ,Internal medicine ,Diabetes mellitus ,Glyburide ,Internal Medicine ,Dietary Carbohydrates ,Medicine ,Humans ,Hypoglycemic Agents ,Advanced and Specialized Nursing ,Glycated Hemoglobin ,Cross-Over Studies ,business.industry ,Insulin ,Metabolism ,Carbohydrate ,Middle Aged ,medicine.disease ,Crossover study ,Dietary Fats ,Endocrinology ,Postprandial ,Diabetes Mellitus, Type 2 ,business ,Biomarkers ,medicine.drug - Abstract
OBJECTIVE To compare the effects of a nigh-carbohydrate diet on blood glucose and plasma lipids in NIDDM patients with either mild or severe glucose intolerance. RESEARCH DESIGN AND METHODS A crossover design with a 15-day intervention diet was used. Eighteen patients were separated into two groups on the basis of hypoglycemic treatment (diet, n = 9, or diet plus glibenclamide, n = 9) and were assigned to a 15-day treatment with a high-carbohydrate/low-fiber diet containing 60% energy from carbohydrate and 20% from fat or a low-carbohydrate/low-fiber diet with 40% energy from carbohydrate and 40% from fat and then crossed over to the other diet for 15 more days. RESULTS The high-carbohydrate diet produced a significant increase in postprandial blood glucose in patients on glibenclamide (13.6 ± 1.4 vs. 11.0 ± 1.8 mmol/l, P < 0.002, while no difference was recorded in the group on diet alone (9.7 ± vs. 8.9 ± 0.6 mmol/l). Postprandial insulin levels were significantly higher after the high-carbohydrate diet in the group on diet along (248 ± 32 vs. 192 ± 28 pmol/l, P < 0.01), while no significant differences were observed in the other group (226 ± 19 vs. 202 ± 24 pmol/l) The high-carbohydrate diet also induced a significant increase in fasting plasma triglyceride concentrations in both groups (1.36 ± 0.2 vs. 1.12 ± 0.2 mmol/l, P < 0.05 and 1.4 ± 0.3 vs. 1.1 ± 0.1 mmol/l, P < 0.05). No differences were observed in fasting plasma cholesterol and HDL. CONCLUSIONS The effects of the high-carbohydrate diet on blood glucose control in NIDDM patients differ according to severity of glucose intolerance.
- Published
- 1996
23. A high-monounsaturated-fat/low-carbohydrate diet improves peripheral insulin sensitivity in non-insulin-dependent diabetic patients
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M. Parillo, Stefano Genovese, A. V. Ciardullo, Gabriele Riccardi, A.A. Rivellese, Brunella Capaldo, A. Giacco, Parillo, M, Rivellese, ANGELA ALBAROSA, Ciardullo, Av, Capaldo, Brunella, Giacco, A, Genovese, S, and Riccardi, Gabriele
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Adult ,Blood Glucose ,Male ,medicine.medical_specialty ,Time Factors ,Diet therapy ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Lipoproteins ,Body Mass Index ,Glibenclamide ,Endocrinology ,Insulin resistance ,Dietary Fats, Unsaturated ,Internal medicine ,Diabetes mellitus ,Glyburide ,medicine ,Dietary Carbohydrates ,Humans ,Insulin ,Unsaturated fatty acid ,Pancreatic hormone ,business.industry ,Middle Aged ,medicine.disease ,Combined Modality Therapy ,Postprandial ,Diabetes Mellitus, Type 2 ,Female ,Insulin Resistance ,business ,medicine.drug - Abstract
It is commonly believed that high-carbohydrate (CHO) diets improve peripheral insulin sensitivity; however, this concept is based on anecdotal evidence. Furthermore, it has been demonstrated that in non-insulin-dependent diabetic patients treated with insulin, a high-monounsaturated-fat (MUFA) diet is more effective than a high-complex-CHO diet in reducing blood glucose levels. The aim of our study was to compare the effect of a high-MUFA diet and a high-CHO diet on peripheral insulin sensitivity and metabolic control in non-insulin-dependent diabetic patients. Ten non-insulin-dependent diabetic patients aged 52 +/- 8 years with a body mass index (BMI) of 26.7 +/- 3.5 kg/m2 who were being treated with diet alone (n = 5) or with diet plus glibenclamide (n = 5) were randomly assigned to a 15-day period of either a high-MUFA/low-CHO diet (CHO, 40%; fat, 40%; protein, 20%; fiber, 24g) or a low-MUFA/high-CHO diet (CHO, 60%; fat, 20%; protein, 20%; fiber, 24g) and were then crossed-over to the other diet. Diets were similar in their content of monosaccharides, disaccharides, and saturated fats, and were administered to the patients in a metabolic ward. The dosage of hypoglycemic drugs was maintained at a constant level throughout the study. With the high-MUFA/low-CHO diet, a decrease in both postprandial glucose (8.76 +/- 2.12 v 10.08 +/- 2.76 mmol/L; P < .05) and plasma insulin (195.0 +/- 86.4 v 224.4 +/- 75.6 pmol/L; P < .02) levels was observed. Furthermore, fasting plasma triglyceride levels were reduced after the high-MUFA fat/low-CHO diet (1.16 +/- 0.59 v 1.37 +/- 0.59 mmol/L; P < .01).(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1992
24. Correlates of age at natural menopause in the cohorts of EPIC-Italy
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Rocco Galasso, Anna V. Ciardullo, Franco Berrino, Giovanna Masala, Laura Fiorini, Domenico Palli, Maria Concetta Giurdanella, Salvatore Panico, Elisabetta Fusconi, Carlotta Sacerdote, Rosario Tumino, Egidio Celentano, Amalia Mattiello, Celentano, E, Galasso, R, Berrino, F, Fusconi, E, Giurdanella, Mc, Tumino, R, Sacerdote, C, Fiorini, L, Ciardullo, Av, Mattiello, A, Palli, D, Masala, G, and Panico, Salvatore
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Cancer Research ,medicine.medical_specialty ,Aging ,Alcohol Drinking ,media_common.quotation_subject ,030218 nuclear medicine & medical imaging ,Body Mass Index ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Neoplasms ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,Life Style ,Menstrual cycle ,Menstrual Cycle ,media_common ,Gynecology ,Menarche ,business.industry ,Smoking ,General Medicine ,Middle Aged ,medicine.disease ,Menopause ,Parity ,Oncology ,Italy ,030220 oncology & carcinogenesis ,Educational Status ,Female ,Age of onset ,Parity (mathematics) ,business ,Body mass index ,Demography ,Cohort study ,Contraceptives, Oral - Abstract
A large number of studies have investigated the factors correlated to age at natural menopause in several populations. However, information on genetics and life-style factors influencing the age of onset of menopause in different populations is of current scientific interest. Specifically, for Italian women there are no large population-based data. The EPIC-Italy collaboration is a source of data of this kind; moreover, the geographical distribution of the cohorts (recruited in northern, central and southern Italy) is an added value as regards the scientific interest of these data. A number of biological and life-style-related factors have been analyzed to evaluate their association to the age at natural menopause in 14,454 menopausal women of the EPIC-Italy collaboration. As regards life-style and environmental factors, the main results are: a) women living in different areas of the country have different ages of onset of natural menopause; b) educational level is significantly associated to this age and may explain part of the between-center difference; c) cigarette smoking appears as a major correlate and probably determinant of the age at natural menopause across all the Italian cohorts; d) alcohol consumption does not have any relationship with the age at natural menopause; e) the use of oral contraceptives may influence age at natural menopause. As regards biological factors, short cycles and low parity have been found associated with earlier menopause. Overall, the results concerning menstrual cycles, parity, and cigarette smoking are consistent with the hypothesis that the number of oocytes in the ovary is pre-determined and any acceleration or impairment of the ovarian function leads to reduce the duration of the reproductive life.
25. Effectiveness of the flash glucose monitoring system in preventing severe hypoglycemic episodes and in improving glucose metrics and quality of life in subjects with type 1 diabetes at high risk of acute diabetes complications.
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Dei Cas A, Aldigeri R, Bellei G, Raffaeli D, Di Bartolo P, Sforza A, Marchesini G, Ciardullo AV, Manicardi V, Bianco M, Monesi M, Vacirca A, Cimicchi MC, Sordillo PA, Altini M, Fantuzzi F, and Bonadonna RC
- Subjects
- Adolescent, Adult, Female, Humans, Male, Middle Aged, Young Adult, Diabetes Complications prevention & control, Glycated Hemoglobin analysis, Glycated Hemoglobin metabolism, Hypoglycemic Agents therapeutic use, Prospective Studies, Quality of Life, Blood Glucose analysis, Blood Glucose metabolism, Blood Glucose Self-Monitoring instrumentation, Blood Glucose Self-Monitoring methods, Diabetes Mellitus, Type 1 psychology, Diabetes Mellitus, Type 1 blood, Hypoglycemia prevention & control
- Abstract
Aims: To assess the effectiveness of the intermittent-scanned continuous glucose monitoring (isCGM) system in preventing severe hypoglycemic episodes and in improving glucose parameters and quality of life., Methods: Four hundred T1D individuals were enrolled in a prospective real-word study with an intermittently scanned continuous glucose monitoring device during the 12-months follow-up. The primary endpoint was the incidence of severe hypoglycemic events., Results: 82% of subjects were naïve to the use of the device (group A) and 18% were already wearing the system (group B). The cumulative incidence of severe hypoglycemia (SH) at 12 months was 12.06 per 100 person-year (95% CI: 8.35-16.85) in group A and 10.14 (95% CI: 4.08-20.90) in group B without inter-group differences. In group A there was a significant decrease in SH at 12 months compared to 3 months period (p = 0.005). Time in glucose range significantly increased in both groups accompanied with a significant decrease in glucose variability. HbA1c showed a progressive significant time-dependent decrease in group A. The use of the device significantly improved the perceived quality of life., Conclusion: This study confirmed the effectiveness of the isCGM in reducing hypoglycemic risk without glucose deterioration, with potential benefits on adverse outcomes in T1D individuals., Trial Registration: ClinicalTrials.gov registration no. NCT04060732., (© 2024. The Author(s).)
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- 2024
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26. Efficacy of a training programme for the management of diabetes mellitus in the hospital: A randomized study (stage 2 of GOVEPAZ healthcare).
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Dei Cas A, Aldigeri R, Ridolfi V, Vazzana A, Ciardullo AV, Manicardi V, Sforza A, Tomasi F, Zavaroni D, Zavaroni I, and Bonadonna RC
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- Male, Humans, Middle Aged, Aged, Aged, 80 and over, Female, Blood Glucose, Hospitals, Delivery of Health Care, Diabetes Mellitus, Hypoglycemia prevention & control
- Abstract
Aims: To assess the efficacy of a structured educational intervention for health professionals on the appropriateness of inpatient diabetes care and on some clinical outcomes in hospitalised subjects., Methods: A multicentre (6 regional hospitals) cluster-randomized (2:1) two parallel-group pragmatic intervention trials, as a part of the GOVEPAZ study, was conducted in three clinical settings, that is, Internal Medicine, Surgery and Intensive Care. Intervention consisted of a 2-month structured education of clinical staff to inpatient diabetes care. Twelve wards - 2 for each hospital - and 6 wards - 1 for each hospital - were randomized to usual care and to the intervention arm, respectively. Consecutively hospitalised diabetic subjects (n = 524, age 74 ± 14 years, 57% males, median HbA1C 57 mmol/mol) were included. The clinical appropriateness of inpatient diabetes management was assessed by a previously validated multi-domain performance score (PS). Clinical outcomes included hypoglycemia, glucose control biomarkers, clinical conditions at discharge and inpatient mortality rate., Results: A numerically, but not statistically significant, higher PS (+0.94; 95% C.I.: -0.53 - +2.4) was achieved in the intervention than in the usual care wards. Hypoglycemias (p = 0.32), glucose control (p = 0.89) and survival rates (p = 0.71) were similar in the two experimental arms. Plasma glucose on admission (OR = 1.52 per 1 SD; C.I. 1.07-2.17; p = 0.021) and the number of hypoglycemic events per patient (OR = 1.55 per 1 SD; C.I.:1.11-2.16; p = 0.011) were independently associated with the inpatient mortality rate., Conclusions: Structured education of the clinical staff failed to improve the inpatient appropriateness of diabetes care or clinical outcomes. In-hospital hypoglycemia was confirmed to be an independent indicator of death risk., (© 2023 The Authors. Diabetes/Metabolism Research and Reviews published by John Wiley & Sons Ltd.)
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- 2023
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27. Handwriting characteristics in patients with overt autoimmune hypothyroidism: a prospective case-control study.
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Papi G, Botti C, Ciardullo AV, Coletta I, Gaglianò MS, Paragliola RM, Locantore P, Corsello SM, and Pontecorvi A
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- Adult, Aged, Case-Control Studies, Female, Handwriting, Humans, Male, Middle Aged, Prospective Studies, Hyperthyroidism, Hypothyroidism
- Abstract
Purpose: Previous studies have demonstrated handwriting changes in patients with overt hyperthyroidism due to Graves' disease. The aim of the present study was to investigate handwriting features in patients affected by overt autoimmune hypothyroidism., Methods: Thirty subjects - 24 females and 6 males, mean and median age of 50.15 ± 16.8 years and 52.5 years, respectively - with overt hypothyroidism (OH) related to Hashimoto's thyroiditis (Group 1), and 30 age- and sex-matched euthyroid individuals (Group 2) were recruited to write a "standard text". Group 1 patients repeated the text once the euthyroid state was reached on L-T4 substitution therapy. Group 2 subjects wrote the text again 1 to 4 weeks thereafter. The letters underwent a detailed analysis by a handwriting expert, through inspection, a stereoscopic microscope and a magnifying glass. Furthermore, the time that both Groups took to go through with the text was clocked., Results: None of the handwriting variables differed significantly within each Group and between the two Groups. Hypothyroid patients took significantly more time to go through with the text compared to the time taken once they became euthyroid (3.29 ± 1.66 vs 2.63 ± 1.55 minutes, respectively) and the time taken by the control group (p < 0.01). Of note, three Group 1 patients missed to copy some words or even whole sentences on the paper while they were overtly hypothyroid., Conclusions: The present study demonstrates that handwriting speed is able to disclose the impact of thyroid hormone deficiency on the central nervous system's functions. In particular, the longer time taken to go through with the text and the sentences missed by some hypothyroid patients, are the counterpart of psychomotor slowdown, impaired attention and memory loss peculiar to OH.
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- 2020
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28. A performance score of the quality of inpatient diabetes care is a marker of clinical outcomes and suggests a cause-effect relationship between hypoglycaemia and the risk of in-hospital mortality.
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Dei Cas A, Aldigeri R, Ridolfi V, Vazzana A, Ciardullo AV, Manicardi V, Sforza A, Tomasi F, Zavaroni D, Zavaroni I, and Bonadonna RC
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- Aged, Biomarkers analysis, Blood Glucose analysis, Diabetes Mellitus, Type 1 physiopathology, Diabetes Mellitus, Type 2 physiopathology, Female, Follow-Up Studies, Humans, Hypoglycemia epidemiology, Hypoglycemia pathology, Italy epidemiology, Male, Prognosis, Prospective Studies, Survival Rate, Diabetes Mellitus, Type 1 mortality, Diabetes Mellitus, Type 2 mortality, Hospital Mortality trends, Hospitalization statistics & numerical data, Hypoglycemia mortality, Inpatients statistics & numerical data
- Abstract
Aims: To build a tool to assess the management of inpatients with diabetes mellitus and to investigate its relationship, if any, with clinical outcomes., Materials and Methods: A total of 678 patients from different settings, Internal Medicine (IMU, n = 255), General Surgery (GSU, n = 230) and Intensive Care (ICU, n = 193) Units, were enrolled. A work-flow of clinical care of diabetes was created according to guidelines. The workflow was divided into five different domains: (a) initial assessment; (b) glucose monitoring; (c) medical therapy; (d) consultancies; (e) discharge. Each domain was assessed by a performance score (PS), computed as the sum of the scores achieved in a set of indicators of clinical appropriateness, management and patient empowerment. Appropriate glucose goals were included as intermediate phenotypes. Clinical outcomes included: hypoglycaemia, survival rate and clinical conditions at discharge., Results: The total PS and those of initial assessment and glucose monitoring were significantly lower in GSU with respect to IMU and ICU (P < .0001). The glucose monitoring PS was associated with lower risk of hypoglycaemia (OR = 0.55; P < .0001), whereas both the PSs of glucose monitoring and medical therapy resulted associated with higher in-hospital survival only in the IMU ward (OR = 6.67 P = .001 and OR = 2.38 P = .03, respectively). Instrumental variable analysis with the aid of PS of glucose monitoring showed that hypoglycaemia may play a causal role in in-hospital mortality (P = .04)., Conclusions: The quality of in-hospital care of diabetes may affect patient outcomes, including glucose control and the risk of hypoglycaemia, and through the latter it may influence the risk of in-hospital mortality., (© 2020 John Wiley & Sons Ltd.)
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- 2020
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29. The impact of Graves' disease and its treatment on handwriting characteristics.
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Papi G, Botti C, Corsello SM, Ciardullo AV, Pontecorvi A, and Hegedüs L
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- Adult, Aged, Cohort Studies, Female, Humans, Hyperthyroidism metabolism, Male, Middle Aged, Thyroid Hormones blood, Thyrotropin blood, Young Adult, Graves Disease physiopathology, Handwriting
- Abstract
Background: Thyroid hormones are crucial for metabolism in all tissues in humans, including the nervous system and muscles, and could thus affect handwriting, which is the synthesis of complex and fine movements. Hyperthyroidism, characterized by symptoms such as tremor and weakness, could affect handwriting, although this has not been studied yet. The aim of this study was to evaluate handwriting characteristics before and after therapy for hyperthyroid Graves' disease (GD)., Methods: Twenty-two patients (15 women, 7 men) with untreated GD (median age: 44 years; range: 20-70 years) were asked to write a "standard text" before and 12 months after being rendered euthyroid. The letters underwent a standardized detailed analysis by a handwriting expert, through inspection and stereoscopic microscope and magnifying glass., Results: All patients demonstrated handwriting variations, perceptible even to direct observation. Graphological examination showed statistically significant changes after patients become euthyroid, in the following parameters: size of letters (4.5±1.1 vs. 5.9±1.3 mm; p<0.01), distance between letters (62.9±1.1 vs. 55.2±0.8 mm; p<0.01), width of letters (1.75±0.06 vs. 2.2±0 .06 mm; p<0.01), distance between words (216.2±3.2 vs. 198.7±2.4 mm; p<0.01), extension of letters (8.7±0.2 vs. 7.7±0.2 mm; p<0.01), angles (17±0.3 vs. 15.8±0.4 mm; p<0.01), and groove depth (0.2±0.05 vs. 0.4±0.05 mm; p<0.01)., Conclusions: Hyperthyroid GD was associated with significant changes in handwriting in all patients. Following recovery from hyperthyroidism, a state of hypertrophic and contracted handwriting resulted in greater fluency and fluidity. Variations in handwriting should be included as signs/symptoms in GD.
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- 2014
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30. Joint and distinct risk factors associated with micro- and macrovascular complications in a cohort of type 2 diabetic patients cared through disease management.
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Ciardullo AV, Daghio MM, Bevini M, Feltri G, Novi D, Fattori G, Borsari S, and Donato CD
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- Aged, Aged, 80 and over, Cardiovascular Diseases epidemiology, Cardiovascular Diseases prevention & control, Cohort Studies, Diabetes Mellitus, Type 2 epidemiology, Diabetic Angiopathies epidemiology, Diabetic Angiopathies prevention & control, Disease Management, Female, Humans, Male, Middle Aged, Primary Prevention methods, Primary Prevention statistics & numerical data, Risk Factors, Secondary Prevention methods, Secondary Prevention statistics & numerical data, Diabetes Mellitus, Type 2 complications, Diabetes Mellitus, Type 2 therapy, Diabetic Angiopathies etiology, Managed Care Programs
- Abstract
We analysed the risk factors associated with diabetic complications in the cohort of patients assisted by a type 2 diabetes mellitus (T2DM) shared-care program. We analysed registry data from 16,136 T2DM patients. Of them, 4,781 had microangiopathy, 3,469 CV events. They were 70.5 ± 17.1 years old, 50% were male, disease duration 13.3 ± 7.8 years, BMI 28.7 ± 4.9 kg/m², HbA1c 7.08 ± 1.23%, FBG 134.7 ± 35.7 mg/dl, 2hPPBG 163.9 ± 47.8 mg/dl, 12.5% smokers. Cholesterol 202.5 ± 37.6 mg/dl, HDL 51.4 ± 20.4 mg/dl, LDL 126.5 ± 36.0 mg/dl, triglyceride 146.2 ± 72.4 mg/dl, SBP 137.8 ± 14.2 mmHg, DBP 80.7 ± 10.8 mmHg, 10-year CV risk score 13.7 ± 9.1; 70.4% had no microangiopathy-i.e. renal, retinal, peripheral nerve disease-and 78.5% of patients had no CV events. Age-adjusted risk factors associated with diabetic complications were male gender, HbA1c, 2hPPBG, HDL, and triglyceride. FBG and SBP were associated with microangiopathy, whereas smoking with cardiovascular events. Optimal targets were reached in: FBG 17%, 2hPPBG 8%, HbA1c 21%, cholesterol 17%, HDL 8%, LDL 5%, triglyceride 20%, SBP 13%, DBP 30%. Drug profiles showed 13% using metformin, 28% sulphonilureas, 26% bitherapy, 4% insulin; 12% statins, 16% anti-platelets, 27% anti-hypertensives, 2% anti-coagulants. T2DM patients showed an acceptable CV risk profile. Joint risk factors for diabetic complications were male gender, HbA1c, 2hPPBG, HDL, and triglyceride. Distinct risk factors were FBG and SBP for micro- and smoking for macrovascular disease. A targeted-to-treat approach needs more attention in the care of T2DM patients.
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- 2010
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31. [Effectiveness of the kit Conversation Map in the therapeutic education of diabetic people attending the Diabetes Unit in Carpi, Italy].
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Ciardullo AV, Daghio MM, Fattori G, Giudici G, Rossii L, and Vagnini C
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- Female, Humans, Italy, Male, Middle Aged, Software, Diabetes Mellitus therapy, Patient Education as Topic
- Abstract
We implemented the "Diabetes conversations", programme of the International Diabetes Federation-Europe, characterised by the use of the Conversation Map, an educational interactive kit addressed to groups of diabetic patients on: Living with diabetes, What is diabetes, Healthy diet and physical activity, Initiating insulin therapy. After at least three month from the end of the 4-session course, clinical data of 63 participants from the first 10 groups--age (mean +/- std dev) 61.7 +/- 10.2 years, 56% women, 18.5% T1DM-improved: fasting glycemia decreased from 152.9 +/- 55.2 to 138.2 +/- 38.9 mg/dl (P < 0.05), HbA1c from 8.2 +/- 1.2 to 7.8 +/- 1.4% (P < 0.01), BMI from 27.6 +/- 15.1 to 25.5 +/- 15.5 kg/m2 (P < 0.02). The patients' satisfaction about the topics and the educational materials was very high.The Conversation Maps are useful because: (a) contribute to improve glycometabolic control; (b) educate patients on the main topics related to diabetes; (c) give to the nurse a key and active role in patients'education; (d) facilitate the connection between knowledge and behaviour; (e) involve the volunteers of the diabetic association as tutors; (f) improve the relationship and the communication between the doctor/nurse and the patient.
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- 2010
32. Association between benign paroxysmal positional vertigo and autoimmune chronic thyroiditis.
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Papi G, Corsello SM, Milite MT, Zanni M, Ciardullo AV, Donato CD, and Pontecorvi A
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- Adolescent, Adult, Case-Control Studies, Female, Humans, Iodide Peroxidase immunology, Male, Middle Aged, Thyroglobulin immunology, Thyrotropin blood, Thyroxine blood, Thyroiditis, Autoimmune complications, Vertigo complications
- Published
- 2009
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33. Menstrual cycle length, serum lipids and lipoproteins in a cohort of Italian Mediterranean women: findings from Progetto ATENA.
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Rubba F, Mattiello A, Chiodini P, Celentano E, Galasso R, Ciardullo AV, Gentile M, Triassi M, Rubba P, and Panico S
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- Adult, Aged, Body Mass Index, Cardiovascular Diseases etiology, Cohort Studies, Female, Humans, Middle Aged, Triglycerides blood, Lipids blood, Lipoproteins blood, Menstrual Cycle
- Abstract
Background and Aims: Clinical studies suggest that menstrual irregularities are associated with metabolic and hormonal abnormalities, insulin resistance and a hyperestrogenic/hyperandrogenic imbalance, that may influence the risk of cardiovascular disease., Methods and Results: The association of these abnormalities with the metabolic syndrome suggests that information on lipid patterns at different menstrual cycle length may be of interest in identifying women at higher cardiovascular risk. The association of lipid patterns with menstrual cycle length was evaluated in a cohort of 5062 women participating in the Progetto ATENA Study. Questions were administered to the participants about their cycle lengths at different periods of time over their reproductive life. The period between 20 and 50 years was investigated: normal cycle length was defined as short (
30 days). Perimenopausal women were excluded and variables adjusted for age, BMI and menopausal status. In 4434 participants serum triglycerides were found to increase with an increased number of days in the menstrual cycle: 106 mg/dl in the short cycle pattern (21-26 days); 113 mg/dl in the medium cycle pattern (27-29 days); and 116 mg/dl in the long cycle pattern (30-31 days), whereas total and LDL cholesterol were found to be higher and HDL was lower in women with longer cycles, but the difference was not statistically significant. The results were very similar when the same adjusted analysis was restricted to a subgroup of 3823 women with a stable cycle length over the fourth and the fifth decade of life., Conclusions: These results suggest that cycle length may be a marker of higher cardiovascular risk due to associated metabolic and hormonal patterns. - Published
- 2008
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34. [Prevention of diabetes mellitus complications and improvement of early diagnosis at a population level, through the implementation of integrated disease management in the Modena region].
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Caroli G, Paganelli A, Fattori G, Daghio MM, Guidetti P, Borsari S, Guerzoni A, Petropulacos K, Daya G, and Ciardullo AV
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- Aged, Aged, 80 and over, Biomarkers blood, Diabetes Mellitus, Type 1 blood, Diabetes Mellitus, Type 1 complications, Diabetes Mellitus, Type 2 blood, Diabetes Mellitus, Type 2 complications, Early Diagnosis, Female, Glycated Hemoglobin metabolism, Humans, Italy, Male, Middle Aged, Retrospective Studies, Treatment Outcome, Diabetes Complications prevention & control, Diabetes Mellitus, Type 1 diagnosis, Diabetes Mellitus, Type 1 drug therapy, Diabetes Mellitus, Type 2 diagnosis, Diabetes Mellitus, Type 2 drug therapy, Hypoglycemic Agents therapeutic use
- Abstract
We evaluated the effectiveness of diabetes mellitus disease management, implemented in Modena province since ten years, on the prevention of complications and early diagnoses at a population level. Time trends show that diabetic patients had significantly decreasing values over time of age, diabetes duration, and glycated haemoglobin; and increasing percentage over time of new-onset diabetes and optimal glycaemic control. That indicates an improved ability of early diagnosis and care of diabetes mellitus. It indicates at a population level that the Local Health Unit, as health system, promoted diabetes prevention and its complications.
- Published
- 2008
35. [Assessment of a nursing protocol for the management of hyperglicaemia in hospitalized patients].
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Ciardullo AV, Rossetti L, Daghio MM, Morselli A, Malavasi E, Pasqualini A, Po I, Gilioli F, and Di Donato C
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- Aged, Aged, 80 and over, Female, Hospitalization, Humans, Male, Hyperglycemia drug therapy, Hyperglycemia nursing, Nursing Assessment
- Abstract
Aim: To assess the effectiveness of a nurse-led protocol for the management of hypo/ hyperglicaemia in a medical ward., Methods: Protocols for standard therapy, and parenteral intensive insulin therapy for severe hypo/hyperglycaemia in hospitalised patients were implemented., Period: march-november 2007., Results: 189 patients (19%) were labelled as "hyperglycaemic" at admission in Emergency Department. Median (+/-IQR) age was 77 (70-84) years, 41% were men, with known diabetes 74%, 18% had skin ulcers. Median glycaemia at admission was 144.5 (98-220) mg/dl. Thirty-six percent of patients was euglycaemic (60-126 mg/dl), 3% hypoglycaemic (<60 mg/dl). The glicaemic values ranged from 127-140 mg/dl (9% patients), from 141-280 mg/dl, (40%patients) and > 280 mg/dl (12% patients). The glicaemic values of the 14 patients requiring the intravenous intensive insulin regimen remained in a safe range (80-250 mg/dl) in the first 15 hours from the infusion start. No patient experienced a life-threatening hypoglycaemia nor hypoglycaemic coma. After three days on standard therapy, glicaemic levels were acceptable: 142 (98-185) pre-breakfast, 144(107-200) pre-lunch, 131 (102-190) pre-dinner, 183 (123-230) mg/dl postprandial., Conclusion: Data showed the effectiveness and safety of a nurse-led protocol for the care of hyperglicaemia in a medical ward.
- Published
- 2008
36. Use and misuse of life-tables in vascular surgery reporting: insight by serendipity.
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Coppi G and Ciardullo AV
- Subjects
- Confounding Factors, Epidemiologic, Humans, Meta-Analysis as Topic, Survival Analysis, Aortic Aneurysm surgery, Vascular Surgical Procedures mortality
- Published
- 2007
37. A single-center experience in open and endovascular treatment of hemodynamically unstable and stable patients with ruptured abdominal aortic aneurysms.
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Coppi G, Silingardi R, Gennai S, Saitta G, and Ciardullo AV
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- Aged, Aged, 80 and over, Aortic Aneurysm, Abdominal mortality, Aortic Rupture mortality, Blood Pressure, Female, Follow-Up Studies, Humans, Kaplan-Meier Estimate, Logistic Models, Male, Middle Aged, Reoperation, Retrospective Studies, Time Factors, Treatment Outcome, Angioplasty adverse effects, Aortic Aneurysm, Abdominal physiopathology, Aortic Aneurysm, Abdominal surgery, Aortic Rupture physiopathology, Aortic Rupture surgery, Blood Vessel Prosthesis Implantation adverse effects
- Abstract
Objective: To retrospectively compare a single center's immediate and mid-term outcomes of ruptured abdominal aortic aneurysm open and endovascular repair (EVAR) for two patient groups-hemodynamically stable and unstable patients-in the same time period., Methods: Patients presenting at our center with confirmed rupture of an abdominal aortic aneurysm between December 1999 and April 2006 were considered according to an intention-to-treat model with EVAR. Patients with symptomatic or acute (but not ruptured) AAAs were not included in this study. Thirty-three patients underwent EVAR, and 91 underwent open repair. Seventy-two patients (EVAR, 45%; open, 63%) were classified as hemodynamically unstable at arrival, and 52 were classified as stable (EVAR, 55%; open, 37%). Ninety-seven percent of EVAR procedures commenced under local anesthesia, and 100% of open repairs occurred with general anesthesia. Overall successful graft deployment, 30-day mortality, overall reintervention rate, and complications were the study primary end points., Results: Overall successful graft deployment for EVAR was 91%; for open repair, it was 96%. Overall 30-day mortality for EVAR was 30% (unstable, 53%; stable, 11%), and the rate was 46% for open repair (unstable, 61%; stable, 21%). The EVAR postoperative reintervention rate (within 30 days) was 15% (unstable, 20%; stable, 11%), and for open repair it was 10% (unstable, 9%; stable, 15%). We recorded a 27% severe complication rate for EVAR patients (unstable, 40%; stable, 17%), and for patients treated with open repair, it was 33% (unstable, 35%; stable, 29%). Our overall EVAR eligibility rate was 52%, and our overall EVAR treatment rate was 27%., Conclusions: Our study's overall results for EVAR remain encouraging when compared with those of conventional repair, but large randomized trials are required to confirm the efficacy of the procedure.
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- 2006
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38. Effectiveness and safety of insulin glargine in the therapy of complicated or secondary diabetes: clinical audit.
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Ciardullo AV, Bacchelli M, Daghio MM, and Carapezzi C
- Subjects
- Adrenal Cortex Hormones adverse effects, Aged, Antineoplastic Agents adverse effects, Blood Glucose analysis, Body Mass Index, Body Weight, Cardiovascular Diseases epidemiology, Cardiovascular Diseases etiology, Comorbidity, Diabetes Complications economics, Diabetes Complications epidemiology, Diabetes Mellitus, Type 2 economics, Diabetes Mellitus, Type 2 epidemiology, Diabetic Retinopathy epidemiology, Diabetic Retinopathy etiology, Drug Administration Schedule, Fasting, Female, Glycated Hemoglobin analysis, Humans, Insulin administration & dosage, Insulin economics, Insulin therapeutic use, Insulin Glargine, Insulin, Long-Acting, Male, Middle Aged, Neoplasm Metastasis drug therapy, Neoplasms complications, Neoplasms drug therapy, Neoplasms epidemiology, Renal Insufficiency epidemiology, Renal Insufficiency etiology, Retrospective Studies, Treatment Outcome, Diabetes Complications drug therapy, Diabetes Mellitus, Type 2 drug therapy, Diabetes Mellitus, Type 2 etiology, Insulin analogs & derivatives
- Abstract
We wanted to assess the effectiveness and safety of glargine in the treatment of patients with type 2 diabetes mellitus in secondary failure and/or with severe comorbidities ("T2DM group"), and patients with secondary diabetes after corticosteroid and/or anticancer treatment ("secondary DM group"). We reviewed the records of patients on glargine from 1 August 2004 to 30 July 2005. The after-minus-before change in HbA1c was the main outcome measure. At baseline, the 18 "T2DM" patients had a mean (+/-SD) age of 66.7+/-9.5 years and a diabetes duration of 13.6+/-10.3 years; 52.9% were male. Their fasting plasma glucose (FPG) decreased from 228.6+/-76.6 to 134.6+/-37.5, two-hour post-prandial glycaemia (2hPPG) from 268.2+/-10.4 to 140.6+/-30.8 and HbA1c from 10.4+/-2.3 to 7.9+/-1.6%. Mean daily insulin dosage was 12.0+/-4.8 UI for glargine alone and 37.4+/-22.6 UI for basal-bolus scheme. The daily cost was Euro 0.75 (range Euro 0.31-1.15). The 24 "secondary DM" patients had a mean age of 67.0+/-11.0 years and a diabetes duration of 3.7+/-6.5 years; 54.2% were male and 91.7% had a metastatic cancer. Their FPG decreased from 222.3+/-108.6 to 121.5+/-28.7 mg/dl, 2hPPG from 259.4+/-108.6 to 133.0+/-35.0 mg/dl and HbA1c from 10.1+/-2.5 to 7.6+/-1.3%. Mean daily insulin dosage was 12.5+/-6.1 UI for glargine alone and 27.2+/-9.1 UI for basal-bolus scheme. Mean daily cost was Euro 0.70 (range Euro 0.31-1.38). One (4.2%) cancer patient withdrew from glargine because of nausea. Nine (37.5%) cancer patients had an increase in appetite after glargine therapy, including 3 end-of-life patients. No severe hypoglycaemia occurred. Insulin glargine was safe and effective in improving glycaemic control both in severe "T2DM" and in "secondary DM" patients.
- Published
- 2006
- Full Text
- View/download PDF
39. How to start or change a daily insulin regimen without a specialist in diabetes. Effectiveness and RAND assessment of practical schemes for in-hospital or hospital-based home care services use.
- Author
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Ciardullo AV, Daghio MM, and Carapezzi C
- Subjects
- Blood Glucose analysis, Diabetes Mellitus blood, Drug Administration Schedule, Home Care Services, Humans, Hyperglycemia epidemiology, Hypoglycemic Agents administration & dosage, Hypoglycemic Agents therapeutic use, Insulin therapeutic use, Probability, Diabetes Mellitus drug therapy, Insulin administration & dosage
- Abstract
When the diabetic patient is hospitalised or assisted by a hospital-based home care service, as a rule he/she is not cared for by a diabetologist all day long. The aim of the present work was to perform a RAND assessment of practical schemes to start or change a daily insulin regimen without a diabetologist. We created an expert panel of seven internists and two diabetologists. They judge the appropriateness of each practical scheme using the RAND method. We produced 21 clinical scenarios divided into two groups. The first group of 9 clinical scenarios-i.e., for diabetic patients who 'eat/not-always-eat' and are 'normal-weight/obese/underweight' or with 'renal failure' or 'defedated/end-of-life' or 'vomiting' or on 'parenteral nutrition'-useful for starting a daily insulin regimen without a diabetologist had a median RAND score of 8 (range 7-9). The second one-formed by 12 clinical scenarios useful to change the daily insulin dosage without a diabetologist based on low or high capillary glucose level monitoring-had a median RAND score of 9 (range 7-9). There was a high level of agreement between panellists in judging 'appropriate' the practical schemes to start or change a daily insulin regimen without a diabetologist.
- Published
- 2006
- Full Text
- View/download PDF
40. Assessment of readability and learning of easy-to-read educational health materials designed and written with the help of citizens by means of two non-alternative methods.
- Author
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Daghio MM, Fattori G, and Ciardullo AV
- Subjects
- Adult, Data Collection, Female, Humans, Italy, Male, Middle Aged, Public Health, Comprehension, Health Education, Teaching Materials standards
- Abstract
Objectives: We compared two non-alternative methods to assess the readability and learning of easy-to-read educational health materials co-written by physicians, educators and citizens., Methods: Data from seven easy-to-read materials were analyzed. Readability formulae, and ad hoc data on readability and learning were also computed., Results: The respondents had a mean age of 48.5 +/- 8.3 (SD) years (range 31-57 years). More than two thirds of them were females. About half of the participants had a 'secondary' education or more. According to the readability scores - 54 on average - the booklets resulted to be "easy" for a reader who had received a 'secondary education' or more. Of the 747 participants, 70% of them found the booklet's language to be 'easy' or 'very easy' and 28% 'sufficiently easy' for laypersons to understand. About 98% of the readers found the booklets useful. After reading the booklet 92% (simple knowledge rate) of the readers answered the cognitive items correctly. The after-minus-before net increase in knowledge was 24 +/- 16% and ranged from 8 to 40% (cognitive or knowledge delta)., Conclusions: The availability of readability scores is complementary and it does not replace the need to assess readability and learning by means of structured and tailored questionnaires.
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- 2006
- Full Text
- View/download PDF
41. Evaluation of easy-to-read information material on healthy life-styles written with the help of citizens' collaboration through networking.
- Author
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Daghio MM, Fattori G, and Ciardullo AV
- Subjects
- Adult, Data Collection, Educational Status, Female, Health Promotion, Humans, Italy, Male, Middle Aged, Social Marketing, Communication, Cooperative Behavior, Health Education methods, Life Style, Reading, Residence Characteristics, Social Support, Teaching Materials standards
- Abstract
The objective of this study was to evaluate if easy-to-read information material on the prevention of chronic-degenerative diseases through healthy lifestyle co-written by communicators, educators, physicians and citizens -using a networking strategy- could be judged comprehensible. Readability scores were computed. The survey involved 100 individuals attending our centralized booking centre for medical appointments during an "index week". They filled out an anonymous questionnaire, just before and after they had read the material. Readability and comprehensibility frequencies were calculated. The participants had a mean age of 59.1+/-15.1 (SD) years (range 19-81yrs), 62% were females. Twenty-six percent of them had received no education, 30% "primary", 28% "secondary", and 14% had a "degree". According to readability scores, the booklet was "readable" by all persons who had finished primary school. Of the 100 participants, 40 percent found the booklet's language to be "easy" or "very easy", 46% "sufficiently easy", and 14% "difficult" for laypersons to understand. Ninety-four percent of them found no unintelligible words in the text. Education levels showed no differences. Readers' answers were more correct after they had read the booklet. The pre-test showed that 61+/-26% of the readers answered the comprehensibility items correctly. After reading the booklet, 81+/-17% of them gave correct answers. The after-minus-before net increase in knowledge was +20% (95% CIs +8 to +32%). The booklet was designed and written using a networking strategy with the help of the local population. It was found to be easy to read and quite clear.
- Published
- 2006
42. Comparing outcomes of carotid endarterectomy with international benchmarks: audit from an Italian vascular surgery department.
- Author
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Coppi G, Moratto R, Ragazzi G, Nicolosi E, Silingardi R, Benassi Franciosi G, and Ciardullo AV
- Subjects
- Aged, Carotid Artery, Internal, Carotid Stenosis surgery, Female, Humans, Italy epidemiology, Male, Retrospective Studies, Stroke etiology, Stroke mortality, Survival Rate, Treatment Outcome, Benchmarking methods, Endarterectomy, Carotid, International Cooperation, Medical Audit, Surgery Department, Hospital statistics & numerical data
- Abstract
Background: The aim of this study was to compare the outcomes of carotid endarterectomy (CEA) in the current practice of our department of vascular surgery with international benchmarks., Methods: In-patient data from 488 CEA performed in both symptomatic 145 (29.7%) and asymptomatic 343 (70.3%) patients with a > or = 60% stenosis at the level of the internal carotid artery. Comprehensive retrospective review of the records for all the CEAs performed during a 2-year period. The main outcome measures were death rate, and fatal and non-fatal stroke rates perioperatively, and at 30 and 180 days., Results: The fatal and non-fatal stroke rates of symptomatic patients were: 0.7% perioperatively, 0.7% at 30 days, and 0.7% at 180 days. The fatal and non-fatal stroke rates of asymptomatic patients were: 0.6% perioperatively, 0.6% at 30 days, and 0.3% at 180 days. The death rates of symptomatic patients were 0% for all time periods. The death rates of asymptomatic patients were: 0% perioperatively, 0% at 30 days, and 0.3% at 180 days., Conclusions: The present comprehensive audit shows that our surgeons achieve CEA outcomes comparable with international benchmarks.
- Published
- 2005
43. [Implementing simple tools for clinical practice in primary care: reports from the Project Diabetes registry addressed to primary care groups in Modena].
- Author
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Guerzoni A, De Luca ML, Daya G, Daghio MM, and Ciardullo AV
- Subjects
- Ambulatory Care organization & administration, Glycated Hemoglobin metabolism, Humans, Italy, Practice Patterns, Physicians' statistics & numerical data, Primary Health Care statistics & numerical data, Registries, Diabetes Mellitus blood, Diabetes Mellitus diagnosis, Diabetes Mellitus therapy, Practice Patterns, Physicians' organization & administration, Primary Health Care organization & administration
- Abstract
We implemented simple tools for Clinical Practice in Primary Care, i.e. reports of Diabetes Project's Registry addressed to Primary Care Groups in Modena in order to promote the clinical practice through a detailed peer-review of program indicators. The efforts of health organisations to involve the general practitioners in clinical practice should be improved by implementing audit-and-feedback tools of simple interpretation for clinical practice.
- Published
- 2005
44. At his age. Once upon a time. . .
- Author
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Ciardullo AV
- Subjects
- Aged, Aged, 80 and over, Diagnosis, Differential, Humans, Male, Osteoarthritis diagnosis, Bone Neoplasms diagnosis, Bone Neoplasms secondary, Physician-Patient Relations, Prostatic Neoplasms pathology, Shoulder Pain diagnosis
- Published
- 2005
45. Calendula and thermal baths for treating a high-grade iatrogenic disability.
- Author
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Ciardullo AV
- Subjects
- Foot Dermatoses complications, Foot Dermatoses surgery, Humans, Hydrotherapy, Narration, Nevus complications, Nevus surgery, Pain etiology, Plant Extracts therapeutic use, Self Care, Baths, Calendula, Iatrogenic Disease, Pain Management, Phytotherapy
- Published
- 2005
- Full Text
- View/download PDF
46. Effectiveness and safety of carotid endarterectomy under remifentanil.
- Author
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Coppi G, Moratto R, Ragazzi G, Nicolosi E, Silingardi R, Benassi Franciosi G, Rambaldi M, Navi A, and Ciardullo AV
- Subjects
- Aged, Female, Humans, Male, Pilot Projects, Prospective Studies, Remifentanil, Treatment Outcome, Anesthetics, Intravenous therapeutic use, Carotid Artery, Internal, Carotid Stenosis surgery, Conscious Sedation methods, Endarterectomy, Carotid, Piperidines therapeutic use
- Abstract
Aim: The aim of this study was to evaluate the effectiveness and safety of carotid endarterectomy (CEA) with conscious sedation under remifentanil (Remifentanil anesthesia - RA) vs conventional loco-regional anesthesia (Conventional-LRA) in the current practice of a vascular surgery unit., Methods: We introduced the ''Remifentanil-RA'' in our practice according to a two-step protocol. In the first step we performed a pilot prospective study to assess the procedure's safety and reproducibility in our setting on 60 consecutive patients with symptomatic and/or high-grade (>70%) internal carotid artery stenosis and alternately assigning them either to ''Remifentanil-RA'' or ''Conventional-LRA'' CEA. In the second step we analysed our routine operative records as to effectiveness and safety on 533 patients who consecutively underwent ''Remifentanil-RA'' CEA. We compared them with 533 age- and sex-matched historical controls who underwent ''Conventional-LRA'' CEA., Results: The patients' mean age was 71.2+/-6.8 vs 71.8+/-6.1 (''Remifentanil-RA'' vs ''Conventional-LRA''). About 73% of them were male and 56% had a symptomatic carotid stenosis. Neither the pilot study nor second step comparison showed differences in outcome measures. We found only higher peri-operative nausea/ vomit (3.6% vs 0.4% ''Remifentanil-RA'' vs ''Conventional-LRA'', P<0.0002) and fewer re-operations for post-operative hematomas (3% vs 5.4% respectively, P=0.048)., Conclusions: We found that ''Remifentanil-RA'' CEA was safe, effective and satisfactory. Nevertheless, with the potential problems of intubation and those already found with side effects, a randomized control trial (RCT) is needed in order to prove that this method is superior to ''Conventional-LRA'' CEA.
- Published
- 2005
47. Rosiglitazone improves insulin sensitivity, glucose tolerance and ambulatory blood pressure in subjects with impaired glucose tolerance: does it really work? If yes, is it a novelty?
- Author
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Ciardullo AV
- Subjects
- Blood Glucose analysis, Blood Pressure drug effects, Blood Pressure Monitoring, Ambulatory, Diabetes Mellitus, Type 2 prevention & control, Humans, Rosiglitazone, Glucose Intolerance drug therapy, Hypoglycemic Agents therapeutic use, Insulin Resistance, Thiazolidinediones therapeutic use
- Published
- 2005
- Full Text
- View/download PDF
48. [GPs' self-perception of their own role compared with hospital, ambulatory, academic, and health organisation physicians].
- Author
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Daghio MM, Gaglianò G, Bevini M, Cadioli T, Delvecchio C, Guidetti P, Lorenzetti M, Fattori G, and Ciardullo AV
- Subjects
- Academies and Institutes, Adult, Ambulatory Care, Cross-Sectional Studies, Female, Humans, Male, Medical Staff, Hospital, Middle Aged, Family Practice, Medicine, Self Concept, Specialization
- Abstract
Aim of the present study was to explore how the 76 general practitioners (GPs) - serving Carpi district (90,000 residents) - value their own role compared with the hospital, ambulatory, academic, and health organisation physicians'. GPs had a positive self-image only in comparison with health organisation doctors (7 vs 7 grades). GPs disappointed with themselves when comparing their role with ambulatory (-1.6 grades), academic (-1.9 grades) and hospital doctors (-2.2 grades). Secondarily, GPs perceived patients' valuing their professional role mostly 'subordinate' to the other physicians', except health organisation colleagues'.
- Published
- 2005
49. Pregnant asylum seekers.
- Author
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Daghio MM, Fattori G, Vezzani MD, Borsari S, and Ciardullo AV
- Subjects
- Female, Humans, Italy, Pregnancy, Delivery of Health Care, Emigration and Immigration, Labor, Obstetric, Maternal Health Services
- Published
- 2005
- Full Text
- View/download PDF
50. Surveillance of dietary habits and lifestyles among 5-6 year-old children and their families living in Central-North Italy.
- Author
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Tripodi A, Daghio MM, Severi S, Ferrari L, and Ciardullo AV
- Subjects
- Body Mass Index, Child, Child, Preschool, Communication Barriers, Female, Humans, Italy, Male, Obesity epidemiology, Obesity prevention & control, Reference Values, Risk Factors, Anthropometry, Child Nutritional Physiological Phenomena, Feeding Behavior, Life Style, Population Surveillance
- Abstract
Objectives: To study dietary habits and behaviours of a representative sample of 5-6-year-old children and their families., Methods: A stratified population sample of the general population (5508 children out of 5551 residents) born in 1997 and attending a nursery school was analysed. Weight and height were measured. Information was collected via questionnaire. A "normal" body mass index (BMI) ranged between 13.61-18.09 and 13.31-19.79 kg/m2 for boys and girls respectively., Results: The response rate was 89%. 79% of the boys had a normal BMI, 0.9% had a low BMI, 18% were overweight, and 1.8% was obese; 87% of the girls had a normal BMI, 2.6% had a low BMI, 10% were overweight, and 0.7% were obese. The main sources of dietary information were professionals of the national health system and mass-media. The main barriers to healthy dietary habits were busy daily activities, working timetable, time needed to cook and tasty and healthy food cost. The main changes in dietary habits occurred in the family habits after a child's birth., Conclusions: Our findings showed a crucial role played by professionals of the national health system and by mass-media on eating behaviours among children and their parents. Birth of a child is a receptive context to promote healthy habits.
- Published
- 2005
- Full Text
- View/download PDF
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