191 results on '"Ciaramella, Giuseppe"'
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2. Cytosine base editing inhibits hepatitis B virus replication and reduces HBsAg expression in vitro and in vivo
3. Improved cytosine base editors generated from TadA variants
4. Cytosine base editing enables quadruple-edited allogeneic CART cells for T-ALL
5. Evaluation of cytosine base editing and adenine base editing as a potential treatment for alpha-1 antitrypsin deficiency
6. Base-editing corrects metabolic abnormalities in a humanized mouse model for glycogen storage disease type-Ia
7. A multiclade env–gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques
8. In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates
9. Installation of HbG-Makassar by base editing restores hemoglobin function: a transformative therapy for sickle cell disease
10. Directed evolution of adenine base editors with increased activity and therapeutic application
11. Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines
12. Cytosine base editing inhibits Hepatitis B Virus replication and reduces HBsAg expression in vitro and in vivo
13. Modified mRNA-Based Vaccines Elicit Robust Immune Responses and Protect Guinea Pigs From Ebola Virus Disease
14. Comprehensive genome editing confers ‘off-the-shelf’ CAR-T cells superior efficacy against solid tumors
15. Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques
16. Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease
17. Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses
18. Modified mRNA Vaccines Protect against Zika Virus Infection
19. Modified mRNA/lipid nanoparticle-based vaccines expressing respiratory syncytial virus F protein variants are immunogenic and protective in rodent models of RSV infection
20. Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity
21. High-efficiency base editing for Stargardt disease in mice, non-human primates, and human retina tissue
22. Development of adult hepatocyte culture systems capable of expressing genes coding for the major proteins responsible for foreign compound metabolism
23. Engineered Stem Cell Antibody Paired Evasion 1 (ESCAPE-1): Paired HSC Epitope Engineering and Upregulation of Fetal Hemoglobin for Antibody-Mediated Autologous Hematopoietic Stem Cell Therapy Conditioning for the Treatment of Hemoglobinopathies
24. Engineered Stem Cell Antibody Paired Evasion-2 (ESCAPE-2): Paired HSC Epitope Engineering and Direct Editing of Sickle Allele for Antibody-Mediated Autologous Hematopoietic Stem Cell Therapy Conditioning for the Treatment of Sickle Cell Disease
25. Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses
26. Characterization of humoral and cell-mediated immunity induced by mRNA vaccines expressing influenza hemagglutinin stem and nucleoprotein in mice and nonhuman primates
27. Uptake, Efficacy, and Systemic Distribution of Naked, Inhaled Short Interfering RNA (siRNA) and Locked Nucleic Acid (LNA) Antisense
28. Screening of Chemically Distinct Lipid Nanoparticles In Vivo Using DNA Barcoding Technology Towards Effectively Delivering Messenger RNA to Hematopoietic Stem and Progenitor Cells
29. Conversion of HbS to Hb G-Makassar By Adenine Base Editing Is Compatible with Normal Hemoglobin Function
30. 155 CD5 knockout enhances the potency of multiplex base-edited allogeneic anti-CD5 CAR T-cell therapy for the treatment of T-cell malignancies
31. HCV-NS3 inhibitors: Determination of their kinetic parameters and mechanism
32. Evaluation of the Impact of a Naturally Occurring Beta Hemoglobin Variant, Hb G-Makassar, on Mature Red Blood Cell Function and Pathology in a Sickle Cell Disease Mouse Model
33. Non-Genotoxic Conditioning for Hematopoietic Stem Cell Transplant through Engineered Stem Cell Antibody Paired Evasion (ESCAPE)
34. Rationally Designed Base Editors for Precise Editing of the Sickle Cell Disease Mutation
35. Adenine Base Editing of the Sickle Allele in CD34+ Hematopoietic Stem and Progenitor Cells Eliminates Hemoglobin S
36. 111 Highly efficient multiplexed base editing enables development of universal CD7-targeting CAR-T Cells to treat T-ALL
37. Directed Evolution of Adenine Base Editors with Increased Activity and Therapeutic Application
38. Next-generation cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity
39. Development and Automation of a 384-Well Cell Fusion Assay to Identify Inhibitors of CCR5/CD4-Mediated HIV Virus Entry
40. Highly Efficient Multiplexed Base Editing with Minimized Off-Targets for the Development of Universal CAR-T Cells to Treat Pediatric T-ALL
41. Complementary Base Editing Approaches for the Treatment of Sickle Cell Disease and Beta Thalassemia
42. 2729. mRNA Vaccines Encoding Conserved Influenza Antigens Induce Robust and Durable Immunity in Rhesus Macaques
43. A Modified mRNA Vaccine Targeting Immunodominant NS Epitopes Protects Against Dengue Virus Infection in HLA Class I Transgenic Mice
44. A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection
45. mRNA vaccines against H10N8 and H7N9 influenza viruses of pandemic potential are immunogenic and well tolerated in healthy adults in phase 1 randomized clinical trials
46. Uncovering critical properties of the human respiratory syncytial virus by combining in vitro assays and in silico analyses
47. Corrigendum: Induction of Robust B Cell Responses After Influenza mRNA Vaccination Is Accompanied by Circulating Hemagglutinin-Specific ICOS+ PD-1+ CXCR3+ T Follicular Helper Cells
48. A multiclade env–gagVLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques
49. Multi-antigenic human cytomegalovirus mRNA vaccines that elicit potent humoral and cell-mediated immunity
50. Rhesus Macaque Myeloid-Derived Suppressor Cells Demonstrate T Cell Inhibitory Functions and Are Transiently Increased after Vaccination
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