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22 results on '"Ciampi, Pellegrino"'

1. Microbial signature of plaque and gut in acute coronary syndrome

Author

Pisano, Eugenia, Bugli, Francesca, Severino, Anna, Pedicino, Daniela, Paroni Sterbini, Francesco, Martini, Cecilia, De Maio, Flavio, Vinci, Ramona, Sacconi, Andrea, Canonico, Francesco, D’Aiello, Alessia, Bonanni, Alice, Proto, Luca, Ciampi, Pellegrino, Ponzo, Myriana, Grimaldi, Maria Chiara, Urbani, Andrea, Primiano, Aniello, Gervasoni, Jacopo, Montone, Rocco, Crea, Filippo, Sanguinetti, Maurizio, and Liuzzo, Giovanna

Published
2023
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2. Coronary artery plaque rupture and erosion: Role of wall shear stress profiling and biological patterns in acute coronary syndromes

Author

Russo, Giulio, Pedicino, Daniela, Chiastra, Claudio, Vinci, Ramona, Lodi Rizzini, Maurizio, Genuardi, Lorenzo, Sarraf, Mohammad, d'Aiello, Alessia, Bologna, Marco, Aurigemma, Cristina, Bonanni, Alice, Bellantoni, Antonio, D'Ascenzo, Fabrizio, Ciampi, Pellegrino, Zambrano, Aniello, Mainardi, Luca, Ponzo, Myriana, Severino, Anna, Trani, Carlo, Massetti, Massimo, Gallo, Diego, Migliavacca, Francesco, Maisano, Francesco, Lerman, Amir, Morbiducci, Umberto, Burzotta, Francesco, Crea, Filippo, and Liuzzo, Giovanna

Published
2023
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4. The value of the 12-lead electrocardiogram in the prediction of sudden cardiac death

Author

Calò, Leonardo, primary, Lanza, Oreste, additional, Crescenzi, Cinzia, additional, Parisi, Cristian, additional, Panattoni, Germana, additional, Martino, Annamaria, additional, Rebecchi, Marco, additional, Tarzia, Pierpaolo, additional, Ciampi, Pellegrino, additional, Romeo, Fabiana, additional, Canestrelli, Stefano, additional, Silvetti, Elisa, additional, and De Ruvo, Ermenegildo, additional

Published
2023
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6. GLUT-1/PKM2 loop dysregulation in patients with non-ST-segment elevation myocardial infarction promotes metainflammation.

Author

Canonico, Francesco, Pedicino, Daniela, Severino, Anna, Vinci, Ramona, Flego, Davide, Pisano, Eugenia, d'Aiello, Alessia, Ciampi, Pellegrino, Ponzo, Myriana, Bonanni, Alice, Ciutiis, Astrid De, Russo, Sara, Sario, Marianna Di, Angelini, Giulia, Szczepaniak, Piotr, Baldi, Alfonso, Kapelak, Boguslaw, Wierzbicki, Karol, Montone, Rocco A, and D'Amario, Domenico

Subjects
MYOCARDIAL infarction, PYRUVATES, GLUCOSE transporters, PYRUVATE kinase, NON-ST elevated myocardial infarction, T cells, REGULATOR genes
Abstract

Aims The functional capacity of the immune cells is strongly dependent on their metabolic state and inflammatory responses are characterized by a greater use of glucose in immune cells. This study is aimed to establish the role of glucose metabolism and its players [glucose transporter 1 (GLUT-1) and pyruvate kinase isozyme M2 (PKM2)] in the dysregulation of adaptive immunity and inflammation observed in patients with non-ST-segment elevation myocardial infarction (NSTEMI). Methods and results We enrolled 248 patients allocated to three groups: NSTEMI patients, chronic coronary syndromes (CCS) patients, healthy subjects (HSs). NSTEMI patients showed higher expression of GLUT-1 and an enhanced glucose uptake in T cells when compared with CCS patients (P < 0.0001; P = 0.0101, respectively) and HSs (P = 0.0071; P = 0.0122, respectively). PKM2 had a prevalent nuclear localization in T lymphocytes in NSTEMI (P = 0.0005 for nuclear vs. cytoplasm localization), while in CCS and HS, it was equally distributed in both compartments. In addition, the nuclear fraction of PKM2 was significantly higher in NSTEMI compared with HS (P = 0.0023). In NSTEMI patients, treatment with Shikonin and Fasentin, which inhibits PKM2 enzyme activity and GLUT-1-mediated glucose internalization, respectively, led to a significant reduction in GLUT-1 expression along with the down-regulation of pro-inflammatory cytokine expression. Conclusion NSTEMI patients exhibit dysregulation of the GLUT-1/PKM2 metabolic loop characterized by nuclear translocation of PKM2, where it acts as a transcription regulator of pro-inflammatory genes. This detrimental loop might represent a new therapeutic target for personalized medicine. [ABSTRACT FROM AUTHOR]

Published
2023
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7. GLUT-1/PKM2 loop dysregulation in patients with non-ST-segment elevation myocardial infarction promotes metainflammation

Author

Canonico, Francesco, primary, Pedicino, Daniela, additional, Severino, Anna, additional, Vinci, Ramona, additional, Flego, Davide, additional, Pisano, Eugenia, additional, d’Aiello, Alessia, additional, Ciampi, Pellegrino, additional, Ponzo, Myriana, additional, Bonanni, Alice, additional, De Ciutiis, Astrid, additional, Russo, Sara, additional, Di Sario, Marianna, additional, Angelini, Giulia, additional, Szczepaniak, Piotr, additional, Baldi, Alfonso, additional, Kapelak, Boguslaw, additional, Wierzbicki, Karol, additional, Montone, Rocco A, additional, D’Amario, Domenico, additional, Massetti, Massimo, additional, Guzik, Tomasz J, additional, Crea, Filippo, additional, and Liuzzo, Giovanna, additional

Published
2022
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11. Restricted T-Cell Repertoire in the Epicardial Adipose Tissue of Non-ST Segment Elevation Myocardial Infarction Patients

Author

Pedicino, Daniela, primary, Severino, Anna, additional, Di Sante, Gabriele, additional, De Rosa, Maria Cristina, additional, Pirolli, Davide, additional, Vinci, Ramona, additional, Pazzano, Vincenzo, additional, Giglio, Ada F., additional, Trotta, Francesco, additional, Russo, Giulio, additional, Ruggio, Aureliano, additional, Pisano, Eugenia, additional, d’Aiello, Alessia, additional, Canonico, Francesco, additional, Ciampi, Pellegrino, additional, Cianflone, Domenico, additional, Cianfanelli, Lorenzo, additional, Grimaldi, Maria Chiara, additional, Filomia, Simone, additional, Luciani, Nicola, additional, Glieca, Franco, additional, Bruno, Piergiorgio, additional, Massetti, Massimo, additional, Ria, Francesco, additional, Crea, Filippo, additional, and Liuzzo, Giovanna, additional

Published
2022
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13. Molecular Hallmarks of Ischemia with Non-Obstructive Coronary Arteries: The “INOCA versus Obstructive CCS” Challenge

Author

Bonanni, Alice, primary, d’Aiello, Alessia, additional, Pedicino, Daniela, additional, Di Sario, Marianna, additional, Vinci, Ramona, additional, Ponzo, Myriana, additional, Ciampi, Pellegrino, additional, Lo Curto, Denise, additional, Conte, Cristina, additional, Cribari, Francesco, additional, Canonico, Francesco, additional, Russo, Giulio, additional, Montone, Rocco Antonio, additional, Trani, Carlo, additional, Severino, Anna, additional, Crea, Filippo, additional, and Liuzzo, Giovanna, additional

Published
2022
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14. Monocyte-Platelet Aggregates Triggered by CD31 Molecule in Non-ST Elevation Myocardial Infarction: Clinical Implications in Plaque Rupture

Author

Vinci, Ramona, primary, Pedicino, Daniela, additional, Bonanni, Alice, additional, d'Aiello, Alessia, additional, Pisano, Eugenia, additional, Ponzo, Myriana, additional, Severino, Anna, additional, Ciampi, Pellegrino, additional, Canonico, Francesco, additional, Russo, Giulio, additional, Di Sario, Marianna, additional, Vergallo, Rocco, additional, Filomia, Simone, additional, Montone, Rocco Antonio, additional, Flego, Davide, additional, Stefanini, Lucia, additional, Piacentini, Roberto, additional, Conte, Cristina, additional, Cribari, Francesco, additional, Massetti, Massimo, additional, Crea, Filippo, additional, and Liuzzo, Giovanna, additional

Published
2022
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15. Atrial Functional Tricuspid Regurgitation as a Distinct Pathophysiological and Clinical Entity: No Idiopathic Tricuspid Regurgitation Anymore

Author

Florescu, Diana R., primary, Muraru, Denisa, additional, Volpato, Valentina, additional, Gavazzoni, Mara, additional, Caravita, Sergio, additional, Tomaselli, Michele, additional, Ciampi, Pellegrino, additional, Florescu, Cristina, additional, Bălșeanu, Tudor A., additional, Parati, Gianfranco, additional, and Badano, Luigi P., additional

Published
2022
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16. 144 Atrial and ventricular phenotypes in a cohort of patients with functional tricuspid regurgitation: clinical, echocardiographic, and prognostic aspects

Author

Gavazzoni, Mara, primary, Heilbron, Francesca, additional, Florescu, Denisa, additional, Ciampi, Pellegrino, additional, Guta, Andrada C, additional, Ochoa, Roberto, additional, Tomaselli, Michele, additional, Volpato, Valentina, additional, Oliverio, Giorgio, additional, Caravita, Sergio, additional, Parati, Gianfranco, additional, Muraru, Denisa, additional, and Badano, Luigi, additional

Published
2021
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17. 181 Impact of leaflet-tethering angle correction on the assessment of tricuspid regurgitation severity using the PISA method

Author

Tomaselli, Michele, primary, Gavazzoni, Mara, additional, Muraru, Denisa, additional, Caravita, Sergio, additional, Volpato, Valentina, additional, Oliverio, Giorgio, additional, Ciambellotti, Francesca, additional, Rella, Valeria, additional, Heilbron, Francesca, additional, Menè, Roberto, additional, Cascella, Andrea, additional, Ciampi, Pellegrino, additional, Florescu, Diana Ruxandra, additional, Parati, Gianfranco, additional, and Badano, Luigi Paolo, additional

Published
2021
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18. 145 Prognostic value of three-dimensional echocardiographic assessment of tricuspid valve geometry in atrial and ventricular functional tricuspid regurgitation

Author

Heilbron, Francesca, primary, Gavazzoni, Mara, additional, Florescu, Diana, additional, Ochoa, Roberto, additional, Tomaselli, Michele, additional, Cascella, Andrea, additional, Ciampi, Pellegrino, additional, Rella, Valeria, additional, Volpato, Valentina, additional, Oliverio, Giorgio, additional, Ciambellotti, Francesca, additional, Branzi, Giovanna, additional, Parati, Gianfranco, additional, Badano, Luigi, additional, and Muraru, Denisa, additional

Published
2021
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19. A Novel Monocyte Subset as a Unique Signature of Atherosclerotic Plaque Rupture

Author

Vinci, Ramona, primary, Pedicino, Daniela, additional, Bonanni, Alice, additional, D’Aiello, Alessia, additional, Severino, Anna, additional, Pisano, Eugenia, additional, Ponzo, Myriana, additional, Canonico, Francesco, additional, Ciampi, Pellegrino, additional, Russo, Giulio, additional, Di Sario, Marianna, additional, Montone, Rocco Antonio, additional, Trani, Carlo, additional, Conte, Cristina, additional, Grimaldi, Maria Chiara, additional, Cribari, Francesco, additional, Massetti, Massimo, additional, Crea, Filippo, additional, and Liuzzo, Giovanna, additional

Published
2021
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20. Platelet hyaluronidase 2 enrichment in acute coronary syndromes: a conceivable role in monocyte-platelet aggregate formation

Author

Vinci, Ramona, primary, Pedicino, Daniela, additional, D’Aiello, Alessia, additional, Ciampi, Pellegrino, additional, Ponzo, Myriana, additional, Bonanni, Alice, additional, Russo, Giulio, additional, Montone, Rocco Antonio, additional, Massetti, Massimo, additional, Crea, Filippo, additional, and Liuzzo, Giovanna, additional

Published
2021
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21. GLUT-1/PKM2 loop dysregulation in patients with non-ST-segment elevation myocardial infarction promotes metainflammation

Author

Francesco Canonico, Daniela Pedicino, Anna Severino, Ramona Vinci, Davide Flego, Eugenia Pisano, Alessia d’Aiello, Pellegrino Ciampi, Myriana Ponzo, Alice Bonanni, Astrid De Ciutiis, Sara Russo, Marianna Di Sario, Giulia Angelini, Piotr Szczepaniak, Alfonso Baldi, Boguslaw Kapelak, Karol Wierzbicki, Rocco A Montone, Domenico D’Amario, Massimo Massetti, Tomasz J Guzik, Filippo Crea, Giovanna Liuzzo, Canonico, Francesco, Pedicino, Daniela, Severino, Anna, Vinci, Ramona, Flego, Davide, Pisano, Eugenia, D'Aiello, Alessia, Ciampi, Pellegrino, Ponzo, Myriana, Bonanni, Alice, De Ciutiis, Astrid, Russo, Sara, Di Sario, Marianna, Angelini, Giulia, Szczepaniak, Piotr, Baldi, Alfonso, Kapelak, Boguslaw, Wierzbicki, Karol, Montone, Rocco A, D'Amario, Domenico, Massetti, Massimo, Guzik, Tomasz J, Crea, Filippo, and Liuzzo, Giovanna

Subjects
Physiology, Physiology (medical), Adaptive immunity, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, GLUT-1, Metainflammation, Acute Coronary Syndrome, Precision Medicine, Cardiology and Cardiovascular Medicine, Acute Coronary Syndromes, Immuno-metabolism, PKM2
Abstract

Aims The functional capacity of the immune cells is strongly dependent on their metabolic state and inflammatory responses are characterized by a greater use of glucose in immune cells. This study is aimed to establish the role of glucose metabolism and its players [glucose transporter 1 (GLUT-1) and pyruvate kinase isozyme M2 (PKM2)] in the dysregulation of adaptive immunity and inflammation observed in patients with non-ST-segment elevation myocardial infarction (NSTEMI). Methods and results We enrolled 248 patients allocated to three groups: NSTEMI patients, chronic coronary syndromes (CCS) patients, healthy subjects (HSs). NSTEMI patients showed higher expression of GLUT-1 and an enhanced glucose uptake in T cells when compared with CCS patients (P < 0.0001; P = 0.0101, respectively) and HSs (P = 0.0071; P = 0.0122, respectively). PKM2 had a prevalent nuclear localization in T lymphocytes in NSTEMI (P = 0.0005 for nuclear vs. cytoplasm localization), while in CCS and HS, it was equally distributed in both compartments. In addition, the nuclear fraction of PKM2 was significantly higher in NSTEMI compared with HS (P = 0.0023). In NSTEMI patients, treatment with Shikonin and Fasentin, which inhibits PKM2 enzyme activity and GLUT-1-mediated glucose internalization, respectively, led to a significant reduction in GLUT-1 expression along with the down-regulation of pro-inflammatory cytokine expression. Conclusion NSTEMI patients exhibit dysregulation of the GLUT-1/PKM2 metabolic loop characterized by nuclear translocation of PKM2, where it acts as a transcription regulator of pro-inflammatory genes. This detrimental loop might represent a new therapeutic target for personalized medicine.

Published
2022

22. Assessing Right Atrial Size in Patients with Tricuspid Regurgitation: Importance of the Right Ventricular-Focused View.

Author

Gavazzoni M, Badano LP, Pugliesi GM, Penso M, Hădăreanu DR, Ciampi P, Fisicaro S, Oliverio G, Heilbron F, Tomaselli M, and Muraru D

Abstract

Aims: To assess the accuracy of measuring the right atrial volume (RAV) using two-dimensional echocardiography (2DE) in a right ventricular focused (RVF) view compared to the conventional apical 4-chamber (4Ch) view in patients with secondary tricuspid regurgitation (STR). We also compared the clinical correlates of the measures obtained using different methods., Methods and Results: The accuracy of RAV measurements obtained from 2DE- 4Ch and RVF views in 384 patients with STR were compared using three-dimensional echocardiography (3DE) as a reference. We used the analysis of variance to test the differences among RAVs obtained from the different 2DE and 3DE acquisitions and the receiving operating characteristics (ROC) curves to evaluate the association with the composite endpoint of hospitalization for heart failure or death. Compared to 3DE, RAV was significantly more underestimated when measurements were obtained from 4Ch rather than RVF (-24% vs. -14%, respectively, p<0.001 for both). RAV underestimation in 4Ch and RVF view was relatively larger in lower grades of STR (-28% vs. -17% in mild, -23% vs. -14% in moderate, and -19% vs. -11% in severe STR, p=0.001), and in the atrial compared to ventricular (-28% vs. -22%; p=0.002) STR. RAV measured by 3DE and RVF showed the highest area under the curve (AUC=0.67 for 3DE vs 0.64 for RVF, p=0.05), while 4Ch was significantly less related to the outcomes (AUC: 0.61, p=0.021 vs 3DE RAV)., Conclusions: In patients with STR, the use of RVF view improved the accuracy of 2DE RAV measurement as compared to the conventional 4Ch-derived measurements., (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)

Published
2024
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