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1. The genomic landscape of 2,023 colorectal cancers

Author

Cornish, Alex J., Gruber, Andreas J., Kinnersley, Ben, Chubb, Daniel, Frangou, Anna, Caravagna, Giulio, Noyvert, Boris, Lakatos, Eszter, Wood, Henry M., Thorn, Steve, Culliford, Richard, Arnedo-Pac, Claudia, Househam, Jacob, Cross, William, Sud, Amit, Law, Philip, Leathlobhair, Maire Ni, Hawari, Aliah, Woolley, Connor, Sherwood, Kitty, Feeley, Nathalie, Gül, Güler, Fernandez-Tajes, Juan, Zapata, Luis, Alexandrov, Ludmil B., Murugaesu, Nirupa, Sosinsky, Alona, Mitchell, Jonathan, Lopez-Bigas, Nuria, Quirke, Philip, Church, David N., Tomlinson, Ian P. M., Sottoriva, Andrea, Graham, Trevor A., Wedge, David C., and Houlston, Richard S.

Published
2024
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2. Non-Canonical Activin A Signaling Stimulates Context-Dependent and Cellular-Specific Outcomes in CRC to Promote Tumor Cell Migration and Immune Tolerance.

Author

Wiley, Mark B, Bauer, Jessica, Mehrotra, Kunaal, Zessner-Spitzenberg, Jasmin, Kolics, Zoe, Cheng, Wenxuan, Castellanos, Karla, Nash, Michael G, Gui, Xianyong, Kone, Lyonell, Maker, Ajay V, Qiao, Guilin, Reddi, Deepti, Church, David N, Kerr, Rachel S, Kerr, David J, Grippo, Paul J, and Jung, Barbara

Subjects
activin A, colorectal cancer, digital spatial profiling, metastasis, tumor microenvironment, Cancer, Digestive Diseases, Colo-Rectal Cancer, Good Health and Well Being, Oncology and Carcinogenesis
Abstract

We have shown that activin A (activin), a TGF-β superfamily member, has pro-metastatic effects in colorectal cancer (CRC). In lung cancer, activin activates pro-metastatic pathways to enhance tumor cell survival and migration while augmenting CD4+ to CD8+ communications to promote cytotoxicity. Here, we hypothesized that activin exerts cell-specific effects in the tumor microenvironment (TME) of CRC to promote anti-tumoral activity of immune cells and the pro-metastatic behavior of tumor cells in a cell-specific and context-dependent manner. We generated an Smad4 epithelial cell specific knockout (Smad4-/-) which was crossed with TS4-Cre mice to identify SMAD-specific changes in CRC. We also performed IHC and digital spatial profiling (DSP) of tissue microarrays (TMAs) obtained from 1055 stage II and III CRC patients in the QUASAR 2 clinical trial. We transfected the CRC cells to reduce their activin production and injected them into mice with intermittent tumor measurements to determine how cancer-derived activin alters tumor growth in vivo. In vivo, Smad4-/- mice displayed elevated colonic activin and pAKT expression and increased mortality. IHC analysis of the TMA samples revealed increased activin was required for TGF-β-associated improved outcomes in CRC. DSP analysis identified that activin co-localization in the stroma was coupled with increases in T-cell exhaustion markers, activation markers of antigen presenting cells (APCs), and effectors of the PI3K/AKT pathway. Activin-stimulated PI3K-dependent CRC transwell migration, and the in vivo loss of activin lead to smaller CRC tumors. Taken together, activin is a targetable, highly context-dependent molecule with effects on CRC growth, migration, and TME immune plasticity.

Published
2023

3. Single-cell AI-based detection and prognostic and predictive value of DNA mismatch repair deficiency in colorectal cancer

Author

Glimelius, Bengt, Gogenur, Ismail, Jaeger, Emma, Morgan, Hannah, Orange, Clare, Palles, Claire, Roxburgh, Campbell, Nowak, Marta, Jabbar, Faiz, Rodewald, Ann-Katrin, Gneo, Luciana, Tomasevic, Tijana, Harkin, Andrea, Iveson, Tim, Saunders, Mark, Kerr, Rachel, Oein, Karin, Maka, Noori, Hay, Jennifer, Edwards, Joanne, Tomlinson, Ian, Sansom, Owen, Kelly, Caroline, Pezzella, Francesco, Kerr, David, Easton, Alistair, Domingo, Enric, Koelzer, Viktor H., and Church, David N.

Published
2024
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4. Standardizing data collection in adjuvant colon cancer trials: A consensus project from the IDEA and ACCENT international consortia and national experts

Author

Taieb, Julien, Basile, Debora, Seligmann, Jenny, Argiles, Guillem, André, Thierry, Gallois, Claire, Goldberg, Richard M., Yothers, Greg, Sobrero, Alberto, Meyerhardt, Jeffrey A., Souglakos, John, Labianca, Roberto, Iveson, Tim, Church, David N., Arnold, Dirk, Tie, Jeanne, Gill, Sharlene, Laurent-Puig, Pierre, Yoshino, Takayuki, Lonardi, Sara, and Shi, Qian

Published
2024
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5. Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: a retrospective analysis

Author

Church, David N, Domingo, Enric, Edwards, Joanne, Glimelius, Bengt, Gonegur, Ismail, Harkin, Andrea, Hay, Jen, Iveson, Timothy, Jaeger, Emma, Kelly, Caroline, Kerr, Rachel, Maka, Noori, Morgan, Hannah, Oien, Karen, Orange, Clare, Palles, Claire, Roxburgh, Campbell, Sansom, Owen, Saunders, Mark P, Tomlinson, Ian, Frei, Anja L, McGuigan, Anthony, Sinha, Ritik R A K, Jabbar, Faiz, Gneo, Luciana, Tomasevic, Tijana, Iveson, Tim, Oien, Karin A, Pezzella, Francesco, Campo, Leticia, Browne, Molly, Glaire, Mark, Kildal, Wanja, Danielsen, Havard E, Hay, Jennifer, Kerr, David, and Koelzer, Viktor H

Published
2024
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6. Transformer-based biomarker prediction from colorectal cancer histology: A large-scale multicentric study

Author

Church, David, Domingo, Enric, Edwards, Joanne, Glimelius, Bengt, Gogenur, Ismail, Harkin, Andrea, Hay, Jen, Iveson, Timothy, Jaeger, Emma, Kelly, Caroline, Kerr, Rachel, Maka, Noori, Morgan, Hannah, Oien, Karin, Orange, Clare, Palles, Claire, Roxburgh, Campbell, Sansom, Owen, Saunders, Mark, Tomlinson, Ian, Wagner, Sophia J., Reisenbüchler, Daniel, West, Nicholas P., Niehues, Jan Moritz, Zhu, Jiefu, Foersch, Sebastian, Veldhuizen, Gregory Patrick, Quirke, Philip, Grabsch, Heike I., van den Brandt, Piet A., Hutchins, Gordon G.A., Richman, Susan D., Yuan, Tanwei, Langer, Rupert, Jenniskens, Josien C.A., Offermans, Kelly, Mueller, Wolfram, Gray, Richard, Gruber, Stephen B., Greenson, Joel K., Rennert, Gad, Bonner, Joseph D., Schmolze, Daniel, Jonnagaddala, Jitendra, Hawkins, Nicholas J., Ward, Robyn L., Morton, Dion, Seymour, Matthew, Magill, Laura, Nowak, Marta, Hay, Jennifer, Koelzer, Viktor H., Church, David N., Matek, Christian, Geppert, Carol, Peng, Chaolong, Zhi, Cheng, Ouyang, Xiaoming, James, Jacqueline A., Loughrey, Maurice B., Salto-Tellez, Manuel, Brenner, Hermann, Hoffmeister, Michael, Truhn, Daniel, Schnabel, Julia A., Boxberg, Melanie, Peng, Tingying, and Kather, Jakob Nikolas

Published
2023
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7. IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma

Author

Taylor, Chelsea A., Watson, Robert A., Tong, Orion, Ye, Weiyu, Nassiri, Isar, Gilchrist, James J., de los Aires, Alba Verge, Sharma, Piyush Kumar, Koturan, Surya, Cooper, Rosalin A., Woodcock, Victoria K., Jungkurth, Elsita, Shine, Brian, Coupe, Nicholas, Payne, Miranda J., Church, David N., Naranbhai, Vivek, Groha, Stefan, Emery, Paul, Mankia, Kulveer, Freedman, Matthew L., Choueiri, Toni K., Middleton, Mark R., Gusev, Alexander, and Fairfax, Benjamin P.

Published
2022
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8. Patterns of cytotoxic T-cell densities in immunogenic endometrial cancers reveal a potential mechanism for differences in immunotherapy efficacy

Author

Ryan, Neil, primary, Glaire, Mark, additional, Walker, Thomas, additional, ter Haar, Natalja, additional, Ijsselsteijn, Marieke, additional, Bolton, James, additional, de Miranda, Noel, additional, Evans, Gareth, additional, Church, David N, additional, Bosse, Tjalling, additional, and Crosbie, Emma, additional

Published
2024
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10. Tertiary lymphoid structures critical for prognosis in endometrial cancer patients

Author

Horeweg, Nanda, Workel, Hagma H., Loiero, Dominik, Church, David N., Vermij, Lisa, Léon-Castillo, Alicia, Krog, Ricki T., de Boer, Stephanie M., Nout, Remi A., Powell, Melanie E., Mileshkin, Linda R., MacKay, Helen, Leary, Alexandra, Singh, Naveena, Jürgenliemk-Schulz, Ina M., Smit, Vincent T. H. B. M., Creutzberg, Carien L., Koelzer, Viktor H., Nijman, Hans W., Bosse, Tjalling, and de Bruyn, Marco

Published
2022
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11. Promises and challenges of adoptive T-cell therapies for solid tumours

Author

Morotti, Matteo, Albukhari, Ashwag, Alsaadi, Abdulkhaliq, Artibani, Mara, Brenton, James D., Curbishley, Stuart M., Dong, Tao, Dustin, Michael L., Hu, Zhiyuan, McGranahan, Nicholas, Miller, Martin L., Santana-Gonzalez, Laura, Seymour, Leonard W., Shi, Tingyan, Van Loo, Peter, Yau, Christopher, White, Helen, Wietek, Nina, Church, David N., Wedge, David C., and Ahmed, Ahmed A.

Published
2021
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12. The Glasgow Microenvironment Score associates with prognosis and adjuvant chemotherapy response in colorectal cancer

Author

Alexander, Peter G., Roseweir, Antonia K., Pennel, Kathryn A. F., van Wyk, Hester C., Powell, Arfon G. M. T., McMillan, Donald C., Horgan, Paul G., Kelly, Caroline, Hay, Jennifer, Sansom, Owen, Harkin, Andrea, Roxburgh, Campbell S. D., Graham, Janet, Church, David N., Tomlinson, Ian, Saunders, Mark, Iveson, Tim J., Edwards, Joanne, and Park, James H.

Published
2021
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14. Rationale and design of the POLEM trial: avelumab plus fluoropyrimidine-based chemotherapy as adjuvant treatment for stage III mismatch repair deficient or POLE exonuclease domain mutant colon cancer: a phase III randomised study

Author

Lau, David, Kalaitzaki, Eleftheria, Church, David N., Pandha, Hardev, Tomlinson, Ian, Annels, Nicola, Gerlinger, Marco, Sclafani, Francesco, Smith, Gillian, Begum, Ruwaida, Crux, Richard, Gillbanks, Angela, Wordsworth, Sarah, Chau, Ian, Starling, Naureen, Cunningham, David, and Dhillon, Tony

Published
2020
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15. The English National Lynch Syndrome transformation project: an NHS Genomic Medicine Service Alliance (GMSA) programme

Author

Monahan, Kevin J, primary, Ryan, Neil, additional, Monje-Garcia, Laura, additional, Armstrong, Ruth, additional, Church, David N, additional, Cook, Jackie, additional, Elghobashy, Alaa, additional, Lalloo, Fiona, additional, Lane, Sally, additional, McDermott, Frank D, additional, Miles, Tracie, additional, Hardy, Steven A, additional, Tyson, Adele, additional, Wang, Valerie Ya Wen, additional, Kim, Anna, additional, Gelinas, Simone, additional, Faravelli, Francesca, additional, Elmslie, Frances, additional, and Shaw, Adam C, additional

Published
2023
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16. Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis

Author

Brown, Matthew, primary, Leon, Alicia, additional, Kedzierska, Katarzyna, additional, Moore, Charlotte, additional, Belnoue‐Davis, Hayley L, additional, Flach, Susanne, additional, Lydon, John P, additional, DeMayo, Francesco J, additional, Lewis, Annabelle, additional, Bosse, Tjalling, additional, Tomlinson, Ian, additional, and Church, David N, additional

Published
2023
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17. Transformer-based biomarker prediction from colorectal cancer histology: A large-scale multicentric study

Author

Wagner, Sophia J., primary, Reisenbüchler, Daniel, additional, West, Nicholas P., additional, Niehues, Jan Moritz, additional, Zhu, Jiefu, additional, Foersch, Sebastian, additional, Veldhuizen, Gregory Patrick, additional, Quirke, Philip, additional, Grabsch, Heike I., additional, van den Brandt, Piet A., additional, Hutchins, Gordon G.A., additional, Richman, Susan D., additional, Yuan, Tanwei, additional, Langer, Rupert, additional, Jenniskens, Josien C.A., additional, Offermans, Kelly, additional, Mueller, Wolfram, additional, Gray, Richard, additional, Gruber, Stephen B., additional, Greenson, Joel K., additional, Rennert, Gad, additional, Bonner, Joseph D., additional, Schmolze, Daniel, additional, Jonnagaddala, Jitendra, additional, Hawkins, Nicholas J., additional, Ward, Robyn L., additional, Morton, Dion, additional, Seymour, Matthew, additional, Magill, Laura, additional, Nowak, Marta, additional, Hay, Jennifer, additional, Koelzer, Viktor H., additional, Church, David N., additional, Matek, Christian, additional, Geppert, Carol, additional, Peng, Chaolong, additional, Zhi, Cheng, additional, Ouyang, Xiaoming, additional, James, Jacqueline A., additional, Loughrey, Maurice B., additional, Salto-Tellez, Manuel, additional, Brenner, Hermann, additional, Hoffmeister, Michael, additional, Truhn, Daniel, additional, Schnabel, Julia A., additional, Boxberg, Melanie, additional, Peng, Tingying, additional, Kather, Jakob Nikolas, additional, Church, David, additional, Domingo, Enric, additional, Edwards, Joanne, additional, Glimelius, Bengt, additional, Gogenur, Ismail, additional, Harkin, Andrea, additional, Hay, Jen, additional, Iveson, Timothy, additional, Jaeger, Emma, additional, Kelly, Caroline, additional, Kerr, Rachel, additional, Maka, Noori, additional, Morgan, Hannah, additional, Oien, Karin, additional, Orange, Clare, additional, Palles, Claire, additional, Roxburgh, Campbell, additional, Sansom, Owen, additional, Saunders, Mark, additional, and Tomlinson, Ian, additional

Published
2023
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20. Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series

Author

Domingo, Enric, Camps, Carme, Kaisaki, Pamela J, Parsons, Marie J, Mouradov, Dmitri, Pentony, Melissa M, Makino, Seiko, Palmieri, Michelle, Ward, Robyn L, Hawkins, Nicholas J, Gibbs, Peter, Askautrud, Hanne, Oukrif, Dahmane, Wang, Haitao, Wood, Joe, Tomlinson, Evie, Bark, Yasmine, Kaur, Kulvinder, Johnstone, Elaine C, Palles, Claire, Church, David N, Novelli, Marco, Danielsen, Havard E, Sherlock, Jon, Kerr, David, Kerr, Rachel, Sieber, Oliver, Taylor, Jenny C, and Tomlinson, Ian

Published
2018
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23. Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets

Author

Frei, Anja Laura, primary, McGuigan, Anthony, additional, Sinha, Ritik RAK, additional, Glaire, Mark A, additional, Jabbar, Faiz, additional, Gneo, Luciana, additional, Tomasevic, Tijana, additional, Harkin, Andrea, additional, Iveson, Tim, additional, Saunders, Mark, additional, Oien, Karin, additional, Maka, Noori, additional, Pezzella, Francesco, additional, Campo, Leticia, additional, Hay, Jennifer, additional, Edwards, Joanne, additional, Sansom, Owen, additional, Kelly, Caroline, additional, Tomlinson, Ian, additional, Kildal, Wanja, additional, Kerr, Rachel, additional, Kerr, David, additional, Danielsen, Havard Emil, additional, Domingo, Enric, additional, Church, David N, additional, and Koelzer, Viktor Hendrik, additional

Published
2023
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26. Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study

Author

Domingo, Enric, Freeman-Mills, Luke, Rayner, Emily, Glaire, Mark, Briggs, Sarah, Vermeulen, Louis, Fessler, Evelyn, Medema, Jan Paul, Boot, Arnoud, Morreau, Hans, van Wezel, Tom, Liefers, Gerrit-Jan, Lothe, Ragnhild A, Danielsen, Stine A, Sveen, Anita, Nesbakken, Arild, Zlobec, Inti, Lugli, Alessandro, Koelzer, Viktor H, Berger, Martin D, Castellví-Bel, Sergi, Muñoz, Jenifer, de Bruyn, Marco, Nijman, Hans W, Novelli, Marco, Lawson, Kay, Oukrif, Dahmane, Frangou, Eleni, Dutton, Peter, Tejpar, Sabine, Delorenzi, Mauro, Kerr, Rachel, Kerr, David, Tomlinson, Ian, and Church, David N

Published
2016
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27. Data from Prognostic Integrated Image-Based Immune and Molecular Profiling in Early-Stage Endometrial Cancer

Author

Horeweg, Nanda, primary, de Bruyn, Marco, primary, Nout, Remi A., primary, Stelloo, Ellen, primary, Kedzierska, Katarzyna, primary, León-Castillo, Alicia, primary, Plat, Annechien, primary, Mertz, Kirsten D., primary, Osse, Michelle, primary, Jürgenliemk-Schulz, Ina M., primary, Lutgens, Ludy C.H.W., primary, Jobsen, Jan J., primary, van der Steen-Banasik, Elzbieta M., primary, Smit, Vincent T., primary, Creutzberg, Carien L., primary, Bosse, Tjalling, primary, Nijman, Hans W., primary, Koelzer, Viktor H., primary, and Church, David N., primary

Published
2023
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28. Data from A Transcriptionally Distinct CXCL13+CD103+CD8+ T-cell Population Is Associated with B-cell Recruitment and Neoantigen Load in Human Cancer

Author

Workel, Hagma H., primary, Lubbers, Joyce M., primary, Arnold, Roland, primary, Prins, Thalina M., primary, van der Vlies, Pieter, primary, de Lange, Kim, primary, Bosse, Tjalling, primary, van Gool, Inge C., primary, Eggink, Florine A., primary, Wouters, Maartje C.A., primary, Komdeur, Fenne L., primary, van der Slikke, Elisabeth C., primary, Creutzberg, Carien L., primary, Kol, Arjan, primary, Plat, Annechien, primary, Glaire, Mark, primary, Church, David N., primary, Nijman, Hans W., primary, and de Bruyn, Marco, primary

Published
2023
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29. Supplementary Table 7 from A Transcriptionally Distinct CXCL13+CD103+CD8+ T-cell Population Is Associated with B-cell Recruitment and Neoantigen Load in Human Cancer

Author

Workel, Hagma H., primary, Lubbers, Joyce M., primary, Arnold, Roland, primary, Prins, Thalina M., primary, van der Vlies, Pieter, primary, de Lange, Kim, primary, Bosse, Tjalling, primary, van Gool, Inge C., primary, Eggink, Florine A., primary, Wouters, Maartje C.A., primary, Komdeur, Fenne L., primary, van der Slikke, Elisabeth C., primary, Creutzberg, Carien L., primary, Kol, Arjan, primary, Plat, Annechien, primary, Glaire, Mark, primary, Church, David N., primary, Nijman, Hans W., primary, and de Bruyn, Marco, primary

Published
2023
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30. Supplementary Tables 1-6, 8 from A Transcriptionally Distinct CXCL13+CD103+CD8+ T-cell Population Is Associated with B-cell Recruitment and Neoantigen Load in Human Cancer

Author

Workel, Hagma H., primary, Lubbers, Joyce M., primary, Arnold, Roland, primary, Prins, Thalina M., primary, van der Vlies, Pieter, primary, de Lange, Kim, primary, Bosse, Tjalling, primary, van Gool, Inge C., primary, Eggink, Florine A., primary, Wouters, Maartje C.A., primary, Komdeur, Fenne L., primary, van der Slikke, Elisabeth C., primary, Creutzberg, Carien L., primary, Kol, Arjan, primary, Plat, Annechien, primary, Glaire, Mark, primary, Church, David N., primary, Nijman, Hans W., primary, and de Bruyn, Marco, primary

Published
2023
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31. Supplementary Figures from A Transcriptionally Distinct CXCL13+CD103+CD8+ T-cell Population Is Associated with B-cell Recruitment and Neoantigen Load in Human Cancer

Author

Workel, Hagma H., primary, Lubbers, Joyce M., primary, Arnold, Roland, primary, Prins, Thalina M., primary, van der Vlies, Pieter, primary, de Lange, Kim, primary, Bosse, Tjalling, primary, van Gool, Inge C., primary, Eggink, Florine A., primary, Wouters, Maartje C.A., primary, Komdeur, Fenne L., primary, van der Slikke, Elisabeth C., primary, Creutzberg, Carien L., primary, Kol, Arjan, primary, Plat, Annechien, primary, Glaire, Mark, primary, Church, David N., primary, Nijman, Hans W., primary, and de Bruyn, Marco, primary

Published
2023
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32. Supplementary Data from Prognostic Integrated Image-Based Immune and Molecular Profiling in Early-Stage Endometrial Cancer

Author

Horeweg, Nanda, primary, de Bruyn, Marco, primary, Nout, Remi A., primary, Stelloo, Ellen, primary, Kedzierska, Katarzyna, primary, León-Castillo, Alicia, primary, Plat, Annechien, primary, Mertz, Kirsten D., primary, Osse, Michelle, primary, Jürgenliemk-Schulz, Ina M., primary, Lutgens, Ludy C.H.W., primary, Jobsen, Jan J., primary, van der Steen-Banasik, Elzbieta M., primary, Smit, Vincent T., primary, Creutzberg, Carien L., primary, Bosse, Tjalling, primary, Nijman, Hans W., primary, Koelzer, Viktor H., primary, and Church, David N., primary

Published
2023
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33. Supplementary figure 6 from POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer

Author

van Gool, Inge C., primary, Eggink, Florine A., primary, Freeman-Mills, Luke, primary, Stelloo, Ellen, primary, Marchi, Emanuele, primary, de Bruyn, Marco, primary, Palles, Claire, primary, Nout, Remi A., primary, de Kroon, Cor D., primary, Osse, Elisabeth M., primary, Klenerman, Paul, primary, Creutzberg, Carien L., primary, Tomlinson, Ian P.M., primary, Smit, Vincent T.H.B.M., primary, Nijman, Hans W., primary, Bosse, Tjalling, primary, and Church, David N., primary

Published
2023
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34. Supplementary Table S2 from Frequent Homologous Recombination Deficiency in High-grade Endometrial Carcinomas

Author

de Jonge, Marthe M., primary, Auguste, Aurélie, primary, van Wijk, Lise M., primary, Schouten, Philip C., primary, Meijers, Matty, primary, ter Haar, Natalja T., primary, Smit, Vincent T.H.B.M., primary, Nout, Remi A., primary, Glaire, Mark A., primary, Church, David N., primary, Vrieling, Harry, primary, Job, Bastien, primary, Boursin, Yannick, primary, de Kroon, Cor D., primary, Rouleau, Etienne, primary, Leary, Alexandra, primary, Vreeswijk, Maaike P.G., primary, and Bosse, Tjalling, primary

Published
2023
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35. Table S3 from Adjuvant Treatment for POLE Proofreading Domain–Mutant Cancers: Sensitivity to Radiotherapy, Chemotherapy, and Nucleoside Analogues

Author

Van Gool, Inge C., primary, Rayner, Emily, primary, Osse, Elisabeth M., primary, Nout, Remi A., primary, Creutzberg, Carien L., primary, Tomlinson, Ian P.M., primary, Church, David N., primary, Smit, Vincent T.H.B.M., primary, de Wind, Niels, primary, Bosse, Tjalling, primary, and Drost, Mark, primary

Published
2023
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36. Supplementary figure 1 from POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer

Author

van Gool, Inge C., primary, Eggink, Florine A., primary, Freeman-Mills, Luke, primary, Stelloo, Ellen, primary, Marchi, Emanuele, primary, de Bruyn, Marco, primary, Palles, Claire, primary, Nout, Remi A., primary, de Kroon, Cor D., primary, Osse, Elisabeth M., primary, Klenerman, Paul, primary, Creutzberg, Carien L., primary, Tomlinson, Ian P.M., primary, Smit, Vincent T.H.B.M., primary, Nijman, Hans W., primary, Bosse, Tjalling, primary, and Church, David N., primary

Published
2023
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37. Figure S1 from Adjuvant Treatment for POLE Proofreading Domain–Mutant Cancers: Sensitivity to Radiotherapy, Chemotherapy, and Nucleoside Analogues

Author

Van Gool, Inge C., primary, Rayner, Emily, primary, Osse, Elisabeth M., primary, Nout, Remi A., primary, Creutzberg, Carien L., primary, Tomlinson, Ian P.M., primary, Church, David N., primary, Smit, Vincent T.H.B.M., primary, de Wind, Niels, primary, Bosse, Tjalling, primary, and Drost, Mark, primary

Published
2023
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38. Supplementary figure 4 from POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer

Author

van Gool, Inge C., primary, Eggink, Florine A., primary, Freeman-Mills, Luke, primary, Stelloo, Ellen, primary, Marchi, Emanuele, primary, de Bruyn, Marco, primary, Palles, Claire, primary, Nout, Remi A., primary, de Kroon, Cor D., primary, Osse, Elisabeth M., primary, Klenerman, Paul, primary, Creutzberg, Carien L., primary, Tomlinson, Ian P.M., primary, Smit, Vincent T.H.B.M., primary, Nijman, Hans W., primary, Bosse, Tjalling, primary, and Church, David N., primary

Published
2023
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39. Supplementary table 2 from POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer

Author

van Gool, Inge C., primary, Eggink, Florine A., primary, Freeman-Mills, Luke, primary, Stelloo, Ellen, primary, Marchi, Emanuele, primary, de Bruyn, Marco, primary, Palles, Claire, primary, Nout, Remi A., primary, de Kroon, Cor D., primary, Osse, Elisabeth M., primary, Klenerman, Paul, primary, Creutzberg, Carien L., primary, Tomlinson, Ian P.M., primary, Smit, Vincent T.H.B.M., primary, Nijman, Hans W., primary, Bosse, Tjalling, primary, and Church, David N., primary

Published
2023
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40. Supplementary Figure S2 from Frequent Homologous Recombination Deficiency in High-grade Endometrial Carcinomas

Author

de Jonge, Marthe M., primary, Auguste, Aurélie, primary, van Wijk, Lise M., primary, Schouten, Philip C., primary, Meijers, Matty, primary, ter Haar, Natalja T., primary, Smit, Vincent T.H.B.M., primary, Nout, Remi A., primary, Glaire, Mark A., primary, Church, David N., primary, Vrieling, Harry, primary, Job, Bastien, primary, Boursin, Yannick, primary, de Kroon, Cor D., primary, Rouleau, Etienne, primary, Leary, Alexandra, primary, Vreeswijk, Maaike P.G., primary, and Bosse, Tjalling, primary

Published
2023
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41. Supplementary figure 5 from POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer

Author

van Gool, Inge C., primary, Eggink, Florine A., primary, Freeman-Mills, Luke, primary, Stelloo, Ellen, primary, Marchi, Emanuele, primary, de Bruyn, Marco, primary, Palles, Claire, primary, Nout, Remi A., primary, de Kroon, Cor D., primary, Osse, Elisabeth M., primary, Klenerman, Paul, primary, Creutzberg, Carien L., primary, Tomlinson, Ian P.M., primary, Smit, Vincent T.H.B.M., primary, Nijman, Hans W., primary, Bosse, Tjalling, primary, and Church, David N., primary

Published
2023
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42. Supplementary Methods from Adjuvant Treatment for POLE Proofreading Domain–Mutant Cancers: Sensitivity to Radiotherapy, Chemotherapy, and Nucleoside Analogues

Author

Van Gool, Inge C., primary, Rayner, Emily, primary, Osse, Elisabeth M., primary, Nout, Remi A., primary, Creutzberg, Carien L., primary, Tomlinson, Ian P.M., primary, Church, David N., primary, Smit, Vincent T.H.B.M., primary, de Wind, Niels, primary, Bosse, Tjalling, primary, and Drost, Mark, primary

Published
2023
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43. Supplementary Methods from Frequent Homologous Recombination Deficiency in High-grade Endometrial Carcinomas

Author

de Jonge, Marthe M., primary, Auguste, Aurélie, primary, van Wijk, Lise M., primary, Schouten, Philip C., primary, Meijers, Matty, primary, ter Haar, Natalja T., primary, Smit, Vincent T.H.B.M., primary, Nout, Remi A., primary, Glaire, Mark A., primary, Church, David N., primary, Vrieling, Harry, primary, Job, Bastien, primary, Boursin, Yannick, primary, de Kroon, Cor D., primary, Rouleau, Etienne, primary, Leary, Alexandra, primary, Vreeswijk, Maaike P.G., primary, and Bosse, Tjalling, primary

Published
2023
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44. Supplementary figure 2 from POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer

Author

van Gool, Inge C., primary, Eggink, Florine A., primary, Freeman-Mills, Luke, primary, Stelloo, Ellen, primary, Marchi, Emanuele, primary, de Bruyn, Marco, primary, Palles, Claire, primary, Nout, Remi A., primary, de Kroon, Cor D., primary, Osse, Elisabeth M., primary, Klenerman, Paul, primary, Creutzberg, Carien L., primary, Tomlinson, Ian P.M., primary, Smit, Vincent T.H.B.M., primary, Nijman, Hans W., primary, Bosse, Tjalling, primary, and Church, David N., primary

Published
2023
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45. Supplementary figure 3 from POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer

Author

van Gool, Inge C., primary, Eggink, Florine A., primary, Freeman-Mills, Luke, primary, Stelloo, Ellen, primary, Marchi, Emanuele, primary, de Bruyn, Marco, primary, Palles, Claire, primary, Nout, Remi A., primary, de Kroon, Cor D., primary, Osse, Elisabeth M., primary, Klenerman, Paul, primary, Creutzberg, Carien L., primary, Tomlinson, Ian P.M., primary, Smit, Vincent T.H.B.M., primary, Nijman, Hans W., primary, Bosse, Tjalling, primary, and Church, David N., primary

Published
2023
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46. Supplementary table 1 from POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer

Author

van Gool, Inge C., primary, Eggink, Florine A., primary, Freeman-Mills, Luke, primary, Stelloo, Ellen, primary, Marchi, Emanuele, primary, de Bruyn, Marco, primary, Palles, Claire, primary, Nout, Remi A., primary, de Kroon, Cor D., primary, Osse, Elisabeth M., primary, Klenerman, Paul, primary, Creutzberg, Carien L., primary, Tomlinson, Ian P.M., primary, Smit, Vincent T.H.B.M., primary, Nijman, Hans W., primary, Bosse, Tjalling, primary, and Church, David N., primary

Published
2023
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