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23 results on '"Chung, Grace S"'

4. Aspirin for Secondary Prevention of Cardiovascular Disease in 51 Low-, Middle-, and High-Income Countries

Author

Yoo, Sang Gune K., primary, Chung, Grace S., additional, Bahendeka, Silver K., additional, Sibai, Abla M., additional, Damasceno, Albertino, additional, Farzadfar, Farshad, additional, Rohloff, Peter, additional, Houehanou, Corine, additional, Norov, Bolormaa, additional, Karki, Khem B., additional, Azangou-Khyavy, Mohammadreza, additional, Marcus, Maja E., additional, Aryal, Krishna K., additional, Brant, Luisa C. C., additional, Theilmann, Michaela, additional, Cífková, Renata, additional, Lunet, Nuno, additional, Gurung, Mongal S., additional, Mwangi, Joseph Kibachio, additional, Martins, Joao, additional, Haghshenas, Rosa, additional, Sturua, Lela, additional, Vollmer, Sebastian, additional, Bärnighausen, Till, additional, Atun, Rifat, additional, Sussman, Jeremy B., additional, Singh, Kavita, additional, Saeedi Moghaddam, Sahar, additional, Guwatudde, David, additional, Geldsetzer, Pascal, additional, Manne-Goehler, Jennifer, additional, Huffman, Mark D., additional, Davies, Justine I., additional, and Flood, David, additional

Published
2023
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8. Racial and Sex Inequities in the Use of and Outcomes After Left Ventricular Assist Device Implantation Among Medicare Beneficiaries

Author

Cascino, Thomas M., primary, Somanchi, Sriram, additional, Colvin, Monica, additional, Chung, Grace S., additional, Brescia, Alexander A., additional, Pienta, Michael, additional, Thompson, Michael P., additional, Stewart, James W., additional, Sukul, Devraj, additional, Watkins, Daphne C., additional, Pagani, Francis D., additional, Likosky, Donald S., additional, Aaronson, Keith D., additional, and McCullough, Jeffrey S., additional

Published
2022
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9. Polysaccharide length affects mycobacterial cell shape and antibiotic susceptibility

Author

Massachusetts Institute of Technology. Department of Chemistry, Justen, Alexander M, Hodges, Heather L, Kim, Lili M, Sadecki, Patric W, Porfirio, Sara, Ultee, Eveline, Black, Ian, Chung, Grace S, Briegel, Ariane, Azadi, Parastoo, Kiessling, Laura L, Massachusetts Institute of Technology. Department of Chemistry, Justen, Alexander M, Hodges, Heather L, Kim, Lili M, Sadecki, Patric W, Porfirio, Sara, Ultee, Eveline, Black, Ian, Chung, Grace S, Briegel, Ariane, Azadi, Parastoo, and Kiessling, Laura L

Abstract

Copyright © 2020 The Authors, some rights reserved. Bacteria control the length of their polysaccharides, which can control cell viability, physiology, virulence, and immune evasion. Polysaccharide chain length affects immunomodulation, but its impact on bacterial physiology and antibiotic susceptibility was unclear. We probed the consequences of truncating the mycobacterial galactan, an essential linear polysaccharide of about 30 residues. Galactan covalently bridges cell envelope layers, with the outermost cell wall linkage point occurring at residue 12. Reducing galactan chain length by approximately half compromises fitness, alters cell morphology, and increases the potency of hydrophobic antibiotics. Systematic variation of the galactan chain length revealed that it determines periplasm size. Thus, glycan chain length can directly affect cellular physiology and antibiotic activity, and mycobacterial glycans, not proteins, regulate periplasm size.

Published
2022

10. Racial and Sex Inequities in the Use of and Outcomes After Left Ventricular Assist Device Implantation Among Medicare Beneficiaries

Author

Cascino, Thomas M., Somanchi, Sriram, Colvin, Monica, Chung, Grace S., Brescia, Alexander A., Pienta, Michael, Thompson, Michael P., Stewart II, James W., Sukul, Devraj, Watkins, Daphne C., and Pagani, Francis D.

Subjects
Social Work, Social Sciences, healthcare disparities, FOS: Sociology
Abstract

Background: Racial disparities in access to advanced therapies for heart failure (HF) patients are well documented, although the reasons remain uncertain. We sought to determine the association of race on utilization of ventricular assist device (VAD) and transplant among patients with access to care at VAD centers and if patient preferences impact the effect. Methods: We performed an observational cohort study of ambulatory chronic systolic HF patients with high-risk features and no contraindication to VAD enrolled at 21 VAD centers and followed for 2 years in the REVIVAL study (Registry Evaluation of Vital Information for VADs in Ambulatory Life). We used competing events cause-specific proportional hazard methodology with multiple imputation for missing data. The primary outcomes were (1) VAD/transplant and (2) death. The exposures of interest included race (Black or White), additional demographics, captured social determinants of health, clinician-assessed HF severity, patient-reported quality of life, preference for VAD, and desire for therapies. Results: The study included 377 participants, of whom 100 (26.5%) identified as Black. VAD or transplant was performed in 11 (11%) Black and 62 (22%) White participants, although death occurred in 18 (18%) Black and 36 (13%) White participants. Black race was associated with reduced utilization of VAD and transplant (adjusted hazard ratio, 0.45 [95% CI, 0.23–0.85]) without an increase in death. Preferences for VAD or life-sustaining therapies were similar by race and did not explain racial disparities. Conclusions: Among patients receiving care by advanced HF cardiologists at VAD centers, there is less utilization of VAD and transplant for Black patients even after adjusting for HF severity, quality of life, and social determinants of health, despite similar care preferences. This residual inequity may be a consequence of structural racism and discrimination or provider bias impacting decision-making.

Published
2022
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21. Reply

Author

Chung, Grace S., primary, Lawrence, Ryan E., additional, Rasinski, Kenneth A., additional, Yoon, John D., additional, and Curlin, Farr A., additional

Published
2012
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23. Global Prevalence of Aspirin Use for Primary Prevention of Cardiovascular Disease: A Cross-Sectional Study of Nationally Representative, Individual-Level Data.

Author

Yoo SGK, Chung GS, Bahendeka SK, Sibai AM, Damasceno A, Farzadfar F, Rohloff P, Houehanou C, Norov B, Karki KB, Azangou-Khyavy M, Marcus ME, Aryal KK, Brant LCC, Theilmann M, Cífková R, Lunet N, Gurung MS, Mwangi JK, Martins J, Haghshenas R, Sturua L, Vollmer S, Bärnighausen T, Atun R, Sussman JB, Singh K, Moghaddam SS, Guwatudde D, Geldsetzer P, Manne-Goehler J, Huffman MD, Davies JI, and Flood D

Subjects
Humans, Cross-Sectional Studies, Male, Female, Prevalence, Middle Aged, Platelet Aggregation Inhibitors therapeutic use, Aged, Aspirin therapeutic use, Aspirin administration & dosage, Cardiovascular Diseases prevention & control, Cardiovascular Diseases epidemiology, Primary Prevention methods, Global Health
Abstract

Competing Interests: The authors have no competing interests to declare.

Published
2024
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