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3. Changes in general and COVID-19 vaccine hesitancy among U.S. adults from 2021 to 2022.

Author

Nguyen, Kimberly H., Chung, E. Lisa, McChesney, Cheyenne, Vasudevan, Lavanya, Allen, Jennifer D., and Bednarczyk, Robert A.

Subjects
VACCINE hesitancy, HEALTH attitudes, COVID-19 vaccines, BLACK people, VACCINATION status
Abstract

Introduction: Understanding changes in vaccine hesitancy, overall and by sociodemographic characteristics, may highlight sub-populations for whom more intensive efforts are needed to increase vaccine uptake and confidence. Methods: We analyzed data using the CDC's Research and Development Survey (RANDS), a nationally representative survey of U.S. adults ≥18years, collected from 17 May 2021-30 June 2021 (n=5,458) and 3 November 2022-12 December 2022 (n=6,821). We assessed changes in vaccine hesitancy, changes in vaccine attitudes and attitudes, and factors associated with hesitancy toward both vaccines in general and COVID-19 vaccines among a nationally representative sample of U.S. adults. Results: Although COVID-19 vaccination (≥1 dose) increased from 67.2% (2021) to 74.7% (2022), COVID-19 vaccine hesitancy increased from 40.7% to 44.6% during the same period. During the same period, hesitancy toward both COVID-19 vaccines and vaccines in general increased among those who were aged ≥65 years and who were non-Hispanic White. However, COVID-19 vaccine hesitancy decreased among non-Hispanic Black adults. Current or former smokers were more hesitant toward vaccines in general (aPR = 1.13, 95%CI: 1.03-1.24) and toward COVID-19 vaccines (aPR = 1.08, 95%CI: 1.01-1.16) compared to never smokers. Among adults who did not receive any COVID-19 vaccines, COVID-19 vaccine hesitancy increased from 86.6% in 2021 to 92.4% in 2022. Furthermore, belief in the overall social benefit of the COVID-19 vaccine decreased from 47.5% to 25.1%. Conclusion: This study highlights concerning trends in vaccine hesitancy and uptake of the COVID-19 and other recommended vaccines. We found that some high-risk groups (e.g. smokers) and population subgroups have become more vaccine hesitant, suggesting the need for improved and intensified strategies to increase vaccine confidence and uptake. Future research may focus on qualitative inquiry to understand specific concerns and determinants contributing to increased hesitancy among these groups to help inform interventions and communication campaigns to support vaccination. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Human Herpesvirus 6B (HHV-6B) Detection and Genome-Wide Host Expression Profiles Implicate HHV-6B As a Pulmonary Pathogen after Allogeneic Hematopoietic Cell Transplant

Author

Hill, Joshua A., primary, Lee, Yeon Joo, additional, Vusse, Lisa K Vande, additional, Xie, Hu, additional, Chung, E Lisa, additional, Waghmare, Dr. Alpana, additional, Cheng, Guang-Shing, additional, Zhu, Haiying, additional, Huang, Meei-Li, additional, Hill, Geoffrey R, additional, Jerome, Keith R., additional, Leisenring, Wendy M., additional, Zerr, Danielle, additional, Gharib, Sina A, additional, Dadwal, Sanjeet Singh, additional, and Boeckh, Michael J., additional

Published
2024
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5. Invasive Fungal Infections After CLAG-M/CLAG Chemotherapy for Acute Myeloid Leukemia and High-Grade Myeloid Neoplasms

Author

Lindsay, Julian, primary, Walti, Carla S., additional, Halpern, Anna B, additional, Xie, Hu, additional, Chung, E Lisa, additional, Schonhoff, Kelda G, additional, Huebner, Emily M, additional, Cheng, Guang-Shing, additional, Kimball, Louise, additional, Leisenring, Wendy M, additional, Greenwood, Matthew, additional, Chen, Sharon C-A, additional, Kong, David CM, additional, Slavin, Monica A., additional, Boeckh, Michael, additional, Fredricks, David, additional, Liu, Catherine, additional, Pergam, Steven A., additional, Walter, Roland B, additional, and Hill, Joshua A., additional

Published
2023
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6. Infectious complications after intensive chemotherapy with CLAG-M versus 7+3 for AML and other high-grade myeloid neoplasms

Author

Walti, Carla S., primary, Halpern, Anna B., additional, Xie, Hu, additional, Kiem, Erika S., additional, Chung, E. Lisa, additional, Schonhoff, Kelda G., additional, Huebner, Emily M., additional, Delaney, Colleen, additional, Liu, Catherine, additional, Pergam, Steven A., additional, Cheng, Guang-Shing, additional, Kimball, Louise E., additional, Leisenring, Wendy M., additional, Boeckh, Michael, additional, Walter, Roland B., additional, and Hill, Joshua A., additional

Published
2022
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7. Infectious Complications after Intensive Chemotherapy with CLAG-M or '7+3' for Adults with Acute Myeloid Leukemia and Other High-Grade Myeloid Neoplasms

Author

Walti, Carla S., primary, Halpern, Anna B., additional, Xie, Hu, additional, Chung, E. Lisa, additional, Gardner, Kelda M., additional, Huebner, Emily M., additional, Delaney, Colleen, additional, Liu, Catherine, additional, Pergam, Steven A., additional, Cheng, Guang-Shing, additional, Kimball, Louise E., additional, Leisenring, Wendy M., additional, Boeckh, Michael, additional, Walter, Roland B., additional, and Hill, Joshua A., additional

Published
2021
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8. Reliability of Self-Sampling for Accurate Assessment of Respiratory Virus Viral and Immunologic Kinetics.

Author

Waghmare, Alpana, Krantz, Elizabeth M, Baral, Subhasish, Vasquez, Emma, Loeffelholz, Tillie, Chung, E Lisa, Pandey, Urvashi, Kuypers, Jane, Duke, Elizabeth R, Jerome, Keith R, Greninger, Alexander L, Reeves, Daniel B, Hladik, Florian, Cardozo-Ojeda, E Fabian, Boeckh, Michael, and Schiffer, Joshua T

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic demonstrates the need for accurate and convenient approaches to diagnose and therapeutically monitor respiratory viral infections. We demonstrated that self-sampling with mid-nasal foam swabs is well-tolerated and provides quantitative viral output concordant with flocked swabs. Using longitudinal home-based self-sampling, we demonstrate that nasal cytokine levels correlate and cluster according to immune cell of origin. Periods of stable viral loads are followed by rapid elimination, which could be coupled with cytokine expansion and contraction. Nasal foam swab self-sampling at home provides a precise, mechanistic readout of respiratory virus shedding and local immune responses. [ABSTRACT FROM AUTHOR]

Published
2022
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9. Reliability of Self-Sampling for Accurate Assessment of Respiratory Virus Viral and Immunologic Kinetics

Author

Waghmare, Alpana, primary, Krantz, Elizabeth M, additional, Baral, Subhasish, additional, Vasquez, Emma, additional, Loeffelholz, Tillie, additional, Chung, E Lisa, additional, Pandey, Urvashi, additional, Kuypers, Jane, additional, Duke, Elizabeth R, additional, Jerome, Keith R, additional, Greninger, Alexander L, additional, Reeves, Daniel B, additional, Hladik, Florian, additional, Cardozo-Ojeda, E Fabian, additional, Boeckh, Michael, additional, and Schiffer, Joshua T, additional

Published
2020
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10. Human Herpesvirus 6B and Lower Respiratory Tract Disease After Hematopoietic Cell Transplantation

Author

Hill, Joshua A., primary, Vande Vusse, Lisa K., additional, Xie, Hu, additional, Chung, E. Lisa, additional, Yeung, Cecilia C.S., additional, Seo, Sachiko, additional, Stevens-Ayers, Terry, additional, Fisher, Cynthia E., additional, Huang, Meei-Li, additional, Stewart, F. Marc, additional, Jerome, Keith R., additional, Zerr, Danielle M., additional, Corey, Lawrence, additional, Leisenring, Wendy M., additional, and Boeckh, Michael, additional

Published
2019
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11. Human Herpesvirus 6B and Pulmonary Disease after Hematopoietic Cell Transplantation

Author

Hill, Joshua A, primary, Vande Vusse, Lisa K., additional, Xie, Hu, additional, Chung, E. Lisa, additional, Yeung, Cecilia, additional, Seo, Sachiko, additional, Stevens-Ayers, Terry, additional, Fisher, Cynthia E., additional, Huang, Meei-Li, additional, Stewart, F. Marc, additional, Jerome, Keith R., additional, Zerr, Danielle M., additional, Corey, Lawrence, additional, Leisenring, Wendy M., additional, and Boeckh, Michael, additional

Published
2019
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12. Reliability of self-sampling for accurate assessment of respiratory virus viral and immunologic kinetics.

Author

Waghmare A, Krantz EM, Baral S, Vasquez E, Loeffelholz T, Chung EL, Pandey U, Kuypers J, Duke ER, Jerome KR, Greninger AL, Reeves DB, Hladik F, Cardozo-Ojeda EF, Boeckh M, and Schiffer JT

Abstract

The SARS-CoV-2 pandemic demonstrates the need for accurate and convenient approaches to diagnose and therapeutically monitor respiratory viral infections. We demonstrated that self-sampling with foam swabs at home is well-tolerated and provides quantitative viral output concordant with flocked swabs. Nasal cytokine levels correlate and cluster according to immune cell of origin. Periods of stable viral loads are followed by rapid elimination, which could be coupled with cytokine expansion and contraction using mathematical models. Nasal foam swab self-sampling at home provides a precise, mechanistic readout of respiratory virus shedding and local immune responses.

Published
2020
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