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7. Supplementary Figure 5 from Arrest Defective 1 Autoacetylation Is a Critical Step in Its Ability to Stimulate Cancer Cell Proliferation

Author

Seo, Ji Hae, primary, Cha, Jong-Ho, primary, Park, Ji-Hyeon, primary, Jeong, Chul-Ho, primary, Park, Zee-Yong, primary, Lee, Hye-Suk, primary, Oh, Seung Hyun, primary, Kang, Ju-Hee, primary, Suh, Se Won, primary, Kim, Kyoung Hoon, primary, Ha, Jun Yong, primary, Han, Sang Hee, primary, Kim, Se-Hee, primary, Lee, Ji-Won, primary, Park, Jeong Ae, primary, Jeong, Joo-Won, primary, Lee, Kong-Joo, primary, Oh, Goo Taeg, primary, Lee, Mi-Ni, primary, Kwon, Sung Won, primary, Lee, Seung-Ki, primary, Chun, Kwang-Hoon, primary, Lee, Su-Jae, primary, and Kim, Kyu-Won, primary

Published
2023
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8. Supplementary Materials and Methods, Figure Legends 1-7, Table 1 Legend from Arrest Defective 1 Autoacetylation Is a Critical Step in Its Ability to Stimulate Cancer Cell Proliferation

Author

Seo, Ji Hae, primary, Cha, Jong-Ho, primary, Park, Ji-Hyeon, primary, Jeong, Chul-Ho, primary, Park, Zee-Yong, primary, Lee, Hye-Suk, primary, Oh, Seung Hyun, primary, Kang, Ju-Hee, primary, Suh, Se Won, primary, Kim, Kyoung Hoon, primary, Ha, Jun Yong, primary, Han, Sang Hee, primary, Kim, Se-Hee, primary, Lee, Ji-Won, primary, Park, Jeong Ae, primary, Jeong, Joo-Won, primary, Lee, Kong-Joo, primary, Oh, Goo Taeg, primary, Lee, Mi-Ni, primary, Kwon, Sung Won, primary, Lee, Seung-Ki, primary, Chun, Kwang-Hoon, primary, Lee, Su-Jae, primary, and Kim, Kyu-Won, primary

Published
2023
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9. Data from Arrest Defective 1 Autoacetylation Is a Critical Step in Its Ability to Stimulate Cancer Cell Proliferation

Author

Seo, Ji Hae, primary, Cha, Jong-Ho, primary, Park, Ji-Hyeon, primary, Jeong, Chul-Ho, primary, Park, Zee-Yong, primary, Lee, Hye-Suk, primary, Oh, Seung Hyun, primary, Kang, Ju-Hee, primary, Suh, Se Won, primary, Kim, Kyoung Hoon, primary, Ha, Jun Yong, primary, Han, Sang Hee, primary, Kim, Se-Hee, primary, Lee, Ji-Won, primary, Park, Jeong Ae, primary, Jeong, Joo-Won, primary, Lee, Kong-Joo, primary, Oh, Goo Taeg, primary, Lee, Mi-Ni, primary, Kwon, Sung Won, primary, Lee, Seung-Ki, primary, Chun, Kwang-Hoon, primary, Lee, Su-Jae, primary, and Kim, Kyu-Won, primary

Published
2023
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10. Supplementary Figure 3 from Arrest Defective 1 Autoacetylation Is a Critical Step in Its Ability to Stimulate Cancer Cell Proliferation

Author

Seo, Ji Hae, primary, Cha, Jong-Ho, primary, Park, Ji-Hyeon, primary, Jeong, Chul-Ho, primary, Park, Zee-Yong, primary, Lee, Hye-Suk, primary, Oh, Seung Hyun, primary, Kang, Ju-Hee, primary, Suh, Se Won, primary, Kim, Kyoung Hoon, primary, Ha, Jun Yong, primary, Han, Sang Hee, primary, Kim, Se-Hee, primary, Lee, Ji-Won, primary, Park, Jeong Ae, primary, Jeong, Joo-Won, primary, Lee, Kong-Joo, primary, Oh, Goo Taeg, primary, Lee, Mi-Ni, primary, Kwon, Sung Won, primary, Lee, Seung-Ki, primary, Chun, Kwang-Hoon, primary, Lee, Su-Jae, primary, and Kim, Kyu-Won, primary

Published
2023
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11. Supplementary Figure 4 from Arrest Defective 1 Autoacetylation Is a Critical Step in Its Ability to Stimulate Cancer Cell Proliferation

Author

Seo, Ji Hae, primary, Cha, Jong-Ho, primary, Park, Ji-Hyeon, primary, Jeong, Chul-Ho, primary, Park, Zee-Yong, primary, Lee, Hye-Suk, primary, Oh, Seung Hyun, primary, Kang, Ju-Hee, primary, Suh, Se Won, primary, Kim, Kyoung Hoon, primary, Ha, Jun Yong, primary, Han, Sang Hee, primary, Kim, Se-Hee, primary, Lee, Ji-Won, primary, Park, Jeong Ae, primary, Jeong, Joo-Won, primary, Lee, Kong-Joo, primary, Oh, Goo Taeg, primary, Lee, Mi-Ni, primary, Kwon, Sung Won, primary, Lee, Seung-Ki, primary, Chun, Kwang-Hoon, primary, Lee, Su-Jae, primary, and Kim, Kyu-Won, primary

Published
2023
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12. Supplementary Figure 6 from Arrest Defective 1 Autoacetylation Is a Critical Step in Its Ability to Stimulate Cancer Cell Proliferation

Author

Seo, Ji Hae, primary, Cha, Jong-Ho, primary, Park, Ji-Hyeon, primary, Jeong, Chul-Ho, primary, Park, Zee-Yong, primary, Lee, Hye-Suk, primary, Oh, Seung Hyun, primary, Kang, Ju-Hee, primary, Suh, Se Won, primary, Kim, Kyoung Hoon, primary, Ha, Jun Yong, primary, Han, Sang Hee, primary, Kim, Se-Hee, primary, Lee, Ji-Won, primary, Park, Jeong Ae, primary, Jeong, Joo-Won, primary, Lee, Kong-Joo, primary, Oh, Goo Taeg, primary, Lee, Mi-Ni, primary, Kwon, Sung Won, primary, Lee, Seung-Ki, primary, Chun, Kwang-Hoon, primary, Lee, Su-Jae, primary, and Kim, Kyu-Won, primary

Published
2023
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13. Supplementary Figure 2 from Arrest Defective 1 Autoacetylation Is a Critical Step in Its Ability to Stimulate Cancer Cell Proliferation

Author

Seo, Ji Hae, primary, Cha, Jong-Ho, primary, Park, Ji-Hyeon, primary, Jeong, Chul-Ho, primary, Park, Zee-Yong, primary, Lee, Hye-Suk, primary, Oh, Seung Hyun, primary, Kang, Ju-Hee, primary, Suh, Se Won, primary, Kim, Kyoung Hoon, primary, Ha, Jun Yong, primary, Han, Sang Hee, primary, Kim, Se-Hee, primary, Lee, Ji-Won, primary, Park, Jeong Ae, primary, Jeong, Joo-Won, primary, Lee, Kong-Joo, primary, Oh, Goo Taeg, primary, Lee, Mi-Ni, primary, Kwon, Sung Won, primary, Lee, Seung-Ki, primary, Chun, Kwang-Hoon, primary, Lee, Su-Jae, primary, and Kim, Kyu-Won, primary

Published
2023
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14. Supplementary Figure 7 from Arrest Defective 1 Autoacetylation Is a Critical Step in Its Ability to Stimulate Cancer Cell Proliferation

Author

Seo, Ji Hae, primary, Cha, Jong-Ho, primary, Park, Ji-Hyeon, primary, Jeong, Chul-Ho, primary, Park, Zee-Yong, primary, Lee, Hye-Suk, primary, Oh, Seung Hyun, primary, Kang, Ju-Hee, primary, Suh, Se Won, primary, Kim, Kyoung Hoon, primary, Ha, Jun Yong, primary, Han, Sang Hee, primary, Kim, Se-Hee, primary, Lee, Ji-Won, primary, Park, Jeong Ae, primary, Jeong, Joo-Won, primary, Lee, Kong-Joo, primary, Oh, Goo Taeg, primary, Lee, Mi-Ni, primary, Kwon, Sung Won, primary, Lee, Seung-Ki, primary, Chun, Kwang-Hoon, primary, Lee, Su-Jae, primary, and Kim, Kyu-Won, primary

Published
2023
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15. Supplementary Figure 1 from Arrest Defective 1 Autoacetylation Is a Critical Step in Its Ability to Stimulate Cancer Cell Proliferation

Author

Seo, Ji Hae, primary, Cha, Jong-Ho, primary, Park, Ji-Hyeon, primary, Jeong, Chul-Ho, primary, Park, Zee-Yong, primary, Lee, Hye-Suk, primary, Oh, Seung Hyun, primary, Kang, Ju-Hee, primary, Suh, Se Won, primary, Kim, Kyoung Hoon, primary, Ha, Jun Yong, primary, Han, Sang Hee, primary, Kim, Se-Hee, primary, Lee, Ji-Won, primary, Park, Jeong Ae, primary, Jeong, Joo-Won, primary, Lee, Kong-Joo, primary, Oh, Goo Taeg, primary, Lee, Mi-Ni, primary, Kwon, Sung Won, primary, Lee, Seung-Ki, primary, Chun, Kwang-Hoon, primary, Lee, Su-Jae, primary, and Kim, Kyu-Won, primary

Published
2023
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16. Supplementary Table 1 from Arrest Defective 1 Autoacetylation Is a Critical Step in Its Ability to Stimulate Cancer Cell Proliferation

Author

Seo, Ji Hae, primary, Cha, Jong-Ho, primary, Park, Ji-Hyeon, primary, Jeong, Chul-Ho, primary, Park, Zee-Yong, primary, Lee, Hye-Suk, primary, Oh, Seung Hyun, primary, Kang, Ju-Hee, primary, Suh, Se Won, primary, Kim, Kyoung Hoon, primary, Ha, Jun Yong, primary, Han, Sang Hee, primary, Kim, Se-Hee, primary, Lee, Ji-Won, primary, Park, Jeong Ae, primary, Jeong, Joo-Won, primary, Lee, Kong-Joo, primary, Oh, Goo Taeg, primary, Lee, Mi-Ni, primary, Kwon, Sung Won, primary, Lee, Seung-Ki, primary, Chun, Kwang-Hoon, primary, Lee, Su-Jae, primary, and Kim, Kyu-Won, primary

Published
2023
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18. ROCK-Isoform-Specific Polarization of Macrophages Associated with Age-Related Macular Degeneration

Author

Zandi, Souska, Nakao, Shintaro, Chun, Kwang-Hoon, Fiorina, Paolo, Sun, Dawei, Arita, Ryoichi, Zhao, Ming, Kim, Enoch, Schueller, Olivier, Campbell, Stewart, Taher, Mahdi, Melhorn, Mark Ivan, Schering, Alexander, Gatti, Francesca, Tezza, Sara, Xie, Fang, Vergani, Andrea, Yoshida, Shigeo, Ishikawa, Keijiro, Yamaguchi, Muneo, Sasaki, Fumiyuki, Schmidt-Ullrich, Ruth, Hata, Yasuaki, Enaida, Hiroshi, Yuzawa, Mitsuko, Yokomizo, Takehiko, Kim, Young-Bum, Sweetnam, Paul, Ishibashi, Tatsuro, and Hafezi-Moghadam, Ali

Published
2015
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28. Cleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells

Author

Yim, Hyungshin, Hwang, In Sun, Choi, Joon-Seok, Chun, Kwang-Hoon, Jin, Ying Hua, Ham, Young-Mi, Lee, Kwang Youl, and Lee, Seung Ki

Subjects
HeLa cells -- Research, Ataxia telangiectasia -- Research, DNA damage -- Research, Biological sciences
Abstract

We show that caspase-3 cleaves Cdc6 at [D.sup.290]/S and [D.sup.422]/G sites, producing p32-tCdc6 (truncated Cdc6) and p49-tCdc6, respectively, during etoposide- or tumor necrosis factor (TNF)-[alpha]--induced apoptosis. The expression of these tCdc6 proteins, p32- and p49-tCdc6, promotes etoposide-induced apoptosis. The expression of tCdc6 perturbs the loading of Mcm2 but not Orc2 onto chromatin and activates ataxia telangiectasia mutated (ATM) and ATM and Rad-3 related (ATR) kinase activities with kinetics similar to that of the phosphorylation of Chk1/2. The activation kinetics are consistent with elevated cellular levels of p53 and mitochondrial levels of Bax. The tCdc6-induced effects are all suppressed to control levels by expressing a Cdc6 mutant that cannot be cleaved by caspase-3 (Cdc6-UM). Cdc6-UM expression attenuates the TNF-[alpha]--induced activation of ATM and caspase-3 activities. When ATM or ATR is down-expressed by using the small interfering RNA technique, the TNF-[alpha]--or tCdc6-induced activation of caspase-3 activities is suppressed in the cells. These results suggest that tCdc6 proteins act as dominant-negative inhibitors of replication initiation and that they disrupt chromatin structure and/or induce DNA damage, leading to the activation of ATM/ATR kinase activation and p53--Bax-mediated apoptosis.

Published
2006

45. Protein kinase C‐δ interacts with and phosphorylates ARD1.

Author

Chun, Kwang‐Hoon, Cho, Seung‐Ju, Lee, Ji‐Won, Seo, Ji Hae, Kim, Kyu‐Won, and Lee, Seung‐Ki

Subjects
*PROTEIN kinases, *CELL communication, *AMINO acid sequence, *MASS spectrometry, *APOPTOSIS, *GLUTATHIONE transferase
Abstract

Protein kinase C‐δ (PKCδ) is a diacylglycerol‐dependent, calcium‐independent novel PKC isoform that is engaged in various cell signaling pathways, such as cell proliferation, apoptosis, inflammation, and oxidative stress. In this study, we searched for proteins that bind PKCδ using a yeast two‐hybrid assay and identified murine arrest‐defective 1 (mARD1) as a binding partner. The interaction between PKCδ and mARD1 was confirmed by glutathione S‐transferase pull‐down and co‐immunoprecipitation assays. Furthermore, recombinant PKCδ phosphorylated full‐length mARD1 protein. The NetPhos online prediction tool suggested PKCδ phosphorylates Ser80, Ser108, and Ser114 residues of mARD1 with the highest probability. Based on these results, we synthesized peptides containing these sites and examined their phosphorylations using recombinant PKCδ. Autoradiography confirmed these sites were efficiently phosphorylated. Consequent mass spectrometry and peptide sequencing in combination with MALDI‐TOF MS/MS confirmed that Ser80 and Ser108 were major phosphorylation sites. The alanine mutations of Ser80 and Ser108 abolished the phosphorylation of mARD1 by PKCδ in 293T cells supporting these observations. In addition, kinase assays using various PKC isotypes showed that Ser80 of ARD1 was phosphorylated by PKCβI and PKCζ isotypes with the highest selectivity, while Ser108 and/or Ser114 were phosphorylated by PKCγ with activities comparable to that of the PKCδ isoform. Overall, these results suggest the possibility that PKCδ transduces signals by regulating phosphorylation of ARD1. [ABSTRACT FROM AUTHOR]

Published
2021
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48. Pharmacological use of a novel scaffold, anomeric N,N-diarylamino tetrahydropyran: molecular similarity search, chemocentric target profiling, and experimental evidence

Author

Venkanna, Arramshetti, primary, Kwon, Oh Wook, additional, Afzal, Sualiha, additional, Jang, Cheongyun, additional, Cho, Kyo Hee, additional, Yadav, Dharmendra K., additional, Kim, Kang, additional, Park, Hyeung-geun, additional, Chun, Kwang-Hoon, additional, Kim, Sun Yeou, additional, and Kim, Mi-hyun, additional

Published
2017
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