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7 results on '"Chuenarom, Weerawan"'

1. Late boosting of the RV144 regimen with AIDSVAX B/E and ALVAC-HIV in HIV-uninfected Thai volunteers: a double-blind, randomised controlled trial

Author

Pitisuthitham, Arom, Sabmee, Yupa, Sirisopana, Narongrid, Eamsila, Chirapa, Savaraj, Prapaporn, Labwech, Wanlaya, Teerachia, Siriluck, Chotirosniramit, Nuntisa, Supindham, Taweewat, Pruenglampoo, Boonlure, Sugandhavesa, Patcharaphan, Kosashunhanan, Natthapol, Kaewthip, Oranitcha, Sroysuwan, Piyathida, Jarujareet, Pawinee, Ratto-Kim, Silvia, Molnar, Sebastian, Schoen, Jesse, Churikanont, Nampueng, Getchalarat, Saowanit, Sangnoi, Nongluck, Nuntapinit, Bessara, Phramtong, Anant, Grandin, Pornsuk V., Madnote, Sirinan, Rittiroongrad, Surawach, Kaewboon, Boot, Trichavaroj, Rapee, Puangkaew, Jiraporn, Chantakulkij, Somsak, Rakyat, Phiromrat, Panjapornsuk, Pornchanok, Tragonlugsana, Nipattra, Chuenarom, Weerawan, de Souza, Mark, Ngauy, Viseth, Phanuphak, Nittaya, Chomchey, Nitiya, Saengtawan, Puttachard, Teeratakulpisarn, Nipat, Rerknimitr, Rungsun, Kroon, Eugene, Lee, Carter A., Chinaworapong, Suchada, Pitisuttithum, Punnee, Nitayaphan, Sorachai, Chariyalertsak, Suwat, Kaewkungwal, Jaranit, Dawson, Peter, Dhitavat, Jittima, Phonrat, Benjaluck, Akapirat, Siriwat, Karasavvas, Nicos, Wieczorek, Lindsay, Polonis, Victoria, Eller, Michael A, Pegu, Poonam, Kim, Dohoon, Schuetz, Alexandra, Jongrakthaitae, Surat, Zhou, Yingjun, Sinangil, Faruk, Phogat, Sanjay, Diazgranados, Carlos A, Tartaglia, James, Heger, Elizabeth, Smith, Kirsten, Michael, Nelson L, Excler, Jean-Louis, Robb, Merlin L, Kim, Jerome H, O'Connell, Robert J, and Vasan, Sandhya

Published
2020
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2. TLR7 agonist, N6-LS and PGT121 delayed viral rebound in SHIV-infected macaques after antiretroviral therapy interruption

Author

Hsu, Denise C., primary, Schuetz, Alexandra, additional, Imerbsin, Rawiwan, additional, Silsorn, Decha, additional, Pegu, Amarendra, additional, Inthawong, Dutsadee, additional, Sopanaporn, Jumpol, additional, Visudhiphan, Pornsuk, additional, Chuenarom, Weerawan, additional, Keawboon, Boot, additional, Shi, Wei, additional, Robb, Merlin L., additional, Mascola, John R., additional, Geleziunas, Romas, additional, Koup, Richard A., additional, Barouch, Dan H., additional, Michael, Nelson L., additional, and Vasan, Sandhya, additional

Published
2021
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3. Late boosting of the RV144 regimen with AIDSVAX B/E and ALVAC-HIV in HIV-uninfected Thai volunteers: a double-blind, randomised controlled trial

Author

Pitisuttithum, Punnee, primary, Nitayaphan, Sorachai, additional, Chariyalertsak, Suwat, additional, Kaewkungwal, Jaranit, additional, Dawson, Peter, additional, Dhitavat, Jittima, additional, Phonrat, Benjaluck, additional, Akapirat, Siriwat, additional, Karasavvas, Nicos, additional, Wieczorek, Lindsay, additional, Polonis, Victoria, additional, Eller, Michael A, additional, Pegu, Poonam, additional, Kim, Dohoon, additional, Schuetz, Alexandra, additional, Jongrakthaitae, Surat, additional, Zhou, Yingjun, additional, Sinangil, Faruk, additional, Phogat, Sanjay, additional, Diazgranados, Carlos A, additional, Tartaglia, James, additional, Heger, Elizabeth, additional, Smith, Kirsten, additional, Michael, Nelson L, additional, Excler, Jean-Louis, additional, Robb, Merlin L, additional, Kim, Jerome H, additional, O'Connell, Robert J, additional, Vasan, Sandhya, additional, Pitisuthitham, Arom, additional, Sabmee, Yupa, additional, Sirisopana, Narongrid, additional, Eamsila, Chirapa, additional, Savaraj, Prapaporn, additional, Labwech, Wanlaya, additional, Teerachia, Siriluck, additional, Chotirosniramit, Nuntisa, additional, Supindham, Taweewat, additional, Pruenglampoo, Boonlure, additional, Sugandhavesa, Patcharaphan, additional, Kosashunhanan, Natthapol, additional, Kaewthip, Oranitcha, additional, Sroysuwan, Piyathida, additional, Jarujareet, Pawinee, additional, Ratto-Kim, Silvia, additional, Molnar, Sebastian, additional, Schoen, Jesse, additional, Churikanont, Nampueng, additional, Getchalarat, Saowanit, additional, Sangnoi, Nongluck, additional, Nuntapinit, Bessara, additional, Phramtong, Anant, additional, Grandin, Pornsuk V., additional, Madnote, Sirinan, additional, Rittiroongrad, Surawach, additional, Kaewboon, Boot, additional, Trichavaroj, Rapee, additional, Puangkaew, Jiraporn, additional, Chantakulkij, Somsak, additional, Rakyat, Phiromrat, additional, Panjapornsuk, Pornchanok, additional, Tragonlugsana, Nipattra, additional, Chuenarom, Weerawan, additional, de Souza, Mark, additional, Ngauy, Viseth, additional, Phanuphak, Nittaya, additional, Chomchey, Nitiya, additional, Saengtawan, Puttachard, additional, Teeratakulpisarn, Nipat, additional, Rerknimitr, Rungsun, additional, Kroon, Eugene, additional, Lee, Carter A., additional, and Chinaworapong, Suchada, additional

Published
2020
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4. Short Communication: Characterization of Cellular Immune Responses in Thai Individuals With and Without HIV-Associated Neurocognitive Disorders

Author

Ratto-Kim, Silvia, Schuetz, Alexandra, Sithinamsuwan, Pasiri, Barber, John, Hutchings, Nicholas, Lerdlum, Sukalaya, Fletcher, James L. K., Phuang-Ngern, Yuwadee, Chuenarom, Weerawan, Tipsuk, Somporn, Pothisri, Mantana, Jadwattanakul, Tanate, Jirajariyavej, Supunnee, Sajjaweerawan, Chayada, Akapirat, Siriwat, Chalermchai, Thep, Suttichom, Duanghathai, Kaewboon, Boot, Prueksakaew, Peeriya, Karnsomlap, Putthachard, Clifford, David, Paul, Robert H., de Souza, Mark S., Kim, Jerome H., Ananworanich, Jintanat, and Valcour, Victor

Subjects
Adult, Male, Immunity, Cellular, AIDS Dementia Complex, Immunology, HIV Infections, CD8-Positive T-Lymphocytes, Middle Aged, Viral Load, Lymphocyte Activation, Thailand, Plasma, Young Adult, Humans, Female
Abstract

HIV-associated neurocognitive disorder (HAND) remains a challenge despite antiretroviral therapy (ART), and has been linked to monocyte/macrophage (M/M) migration to the brain. Due to the potential impact of T cell effector mechanisms in eliminating activated/HIV-infected M/M, T cell activation may play a role in the development of HAND. We sought to investigate the relationship between cognition and both CD8(+) T cell activation (HLA-DR(+)/CD38(+)) and HIV-specific CD8(+) T cell responses at the time of HIV diagnosis and 12 months postinitiation of ART. CD8(+) T cell activation was increased in HAND compared to cognitive normal (NL) individuals and correlated directly with plasma viral load and inversely with the cognitive status. In addition, Gag-specific cytolytic activity (CD107a/b(+)) was decreased in HAND compared with NL individuals and correlated with their neurological testing, suggesting a potential role of cytotoxic CD8(+) T cells in the mechanism of HAND development.

Published
2018

5. Central Nervous System Inflammation and Infection during Early, Nonaccelerated Simian-Human Immunodeficiency Virus Infection in Rhesus Macaques

Author

Hsu, Denise C., primary, Sunyakumthorn, Piyanate, additional, Wegner, Matthew, additional, Schuetz, Alexandra, additional, Silsorn, Decha, additional, Estes, Jacob D., additional, Deleage, Claire, additional, Tomusange, Khamis, additional, Lakhashe, Samir K., additional, Ruprecht, Ruth M., additional, Lombardini, Eric, additional, Im-Erbsin, Rawiwan, additional, Kuncharin, Yanin, additional, Phuang-Ngern, Yuwadee, additional, Inthawong, Dutsadee, additional, Chuenarom, Weerawan, additional, Burke, Robin, additional, Robb, Merlin L., additional, Ndhlovu, Lishomwa C., additional, Ananworanich, Jintanat, additional, Valcour, Victor, additional, O'Connell, Robert J., additional, Spudich, Serena, additional, Michael, Nelson L., additional, and Vasan, Sandhya, additional

Published
2018
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6. Characterization of Cellular Immune Responses in Thai Individuals With and Without HIV-Associated Neurocognitive Disorders.

Author

Ratto-Kim, Silvia, Schuetz, Alexandra, Sithinamsuwan, Pasiri, Barber, John, Hutchings, Nicholas, Lerdlum, Sukalaya, Fletcher, James L. K., Phuang-Ngern, Yuwadee, Chuenarom, Weerawan, Tipsuk, Somporn, Pothisri, Mantana, Jadwattanakul, Tanate, Jirajariyavej, Supunnee, Sajjaweerawan, Chayada, Akapirat, Siriwat, Chalermchai, Thep, Suttichom, Duanghathai, Kaewboon, Boot, Prueksakaew, Peeriya, and Karnsomlap, Putthachard

Abstract

HIV-associated neurocognitive disorder (HAND) remains a challenge despite antiretroviral therapy (ART), and has been linked to monocyte/macrophage (M/M) migration to the brain. Due to the potential impact of T cell effector mechanisms in eliminating activated/HIV-infected M/M, T cell activation may play a role in the development of HAND. We sought to investigate the relationship between cognition and both CD8+ T cell activation (HLA-DR+/CD38+) and HIV-specific CD8+ T cell responses at the time of HIV diagnosis and 12 months postinitiation of ART. CD8+ T cell activation was increased in HAND compared to cognitive normal (NL) individuals and correlated directly with plasma viral load and inversely with the cognitive status. In addition, Gag-specific cytolytic activity (CD107a/b+) was decreased in HAND compared with NL individuals and correlated with their neurological testing, suggesting a potential role of cytotoxic CD8+ T cells in the mechanism of HAND development. [ABSTRACT FROM AUTHOR]

Published
2018
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7. The Thai Phase III Trial (RV144) Vaccine Regimen Induces T Cell Responses That Preferentially Target Epitopes within the V2 Region of HIV-1 Envelope.

Author

De Souza, Mark S., Ratto-Kim, Silvia, Chuenarom, Weerawan, Schuetz, Alexandra, Chantakulkij, Somsak, Nuntapinit, Bessara, Valencia-Micolta, Anais, Thelian, Doris, Nitayaphan, Sorachai, Pitisuttithum, Punnee, Paris, Robert M., Kaewkungwal, Jaranit, Michael, Nelson L., Rerks-Ngarm, Supachai, Mathieson, Bonnie, Marovich, Mary, Currier, Jeffrey R., and Kim, Jerome H.

Subjects
*AIDS vaccines, *HIV, *EPITOPES, *T cells, *CYTOKINES, *INTERLEUKIN-2, *HUMORAL immunity
Abstract

The Thai HIV phase III prime/boost vaccine trial (RV144) using ALVAC-HIV (vCP1521) and AIDSVAX B/E was, to our knowledge, the first to demonstrate acquisition efficacy. Vaccine-induced, cell-mediated immune responses were assessed. T cell epitope mapping studies using IFN-γ ELISPOT was performed on PBMCs from HIV-1-uninfected vaccine (w = 61) and placebo (n = 10) recipients using HIV-1 Env peptides. Positive responses were measured in 25 (41%) vaccinées and were predominantly CD4+ T cell-mediated. Responses were targeted within the HIV Env region, with 15 of 25 (60%) of vaccinées recognizing peptides derived from the V2 region of HIV-1 Env, which includes the 07 integrin binding site. Intracellular cytokine staining confirmed that Env responses predominated (19 of 30; 63% of vaccine recipients) and were mediated by polyfunctional effector memory CD4+ T cells, with the majority of responders producing both IL-2 and IFN-γ (12 of 19; 63%). HIV Env Ab titers were higher in subjects with IL-2 compared with those without IL-2-secreting HIV Env-specific effector memory T cells. Proliferation assays revealed that HIV Ag-speciflc T cells were CD4+, with the majority (80%) expressing CD107a. HTV-specific T cell lines obtained from vaccine recipients confirmed V2 specificity, polyfunctionality, and functional cytolytic capacity. Although the RV144 T cell responses were modest in frequency compared with humoral immune responses, the CD4+ T cell response was directed to HIV-1 Env and more particularly the V2 region [ABSTRACT FROM AUTHOR]

Published
2012
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