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1. Biological effects induced by Gadolinium nanoparticles on Lymphocyte A20 cell line

Author

Gheran Cecilia Virginia, Voicu Sorina Nicoleta, Rigaux Guillaume, Callewaert Maite, Chuburu Francoise, and Dinischiotu Anca

Subjects
Biotechnology, TP248.13-248.65
Abstract

Gadolinium nanoparticles (GdNPs) are potential agents for MRI of lymph nodes. The aim of this study was to evaluate the in vitro effects of 1 μM, 2.5 μM and 5 μM of GdDOTA⊂CS-TPP/HA and GdDOTP⊂CS-TPP/HA NPs on A20 lymphocyte cells exposed for 6 and 24 hours. The total cellular biomass (SRB), lactate dehydrogenase activity (LDH) and oxidative stress parameters, such as reactive oxygen species generation (ROS), reduced glutathione (GSH), malondialdehyde (MDA) and advanced oxidation protein products (AOPP) were analyzed by spectrophotometric and fluorimetric methods. After cells exposure to 1 μM, 2.5 μM and 5 μM of GdDOTP⊂CS-TPP/HA NPs their viability decreased in a time- and dose-dependent manner, whereas for GdDOTA⊂CS-TPP/HA no significant changes were noticed. Both NPs formulations in doses of 1 μM, 2.5 μM, 5 μM did not affect the plasma membrane at each time point tested. The levels of ROS, MDA and AOPP increased proportionally with the concentration and exposure time. GSH concentration decreased significantly for all doses of both NPs tested. Taken together our data suggest that, GdDOTP⊂CS-TPP/HA and GdDOTA⊂CS-TPP/HA NPs induced oxidative stress in A20 lymphocyte cells which was counteracted by the cells antioxidant defense system to a certain extend.

Published
2017
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6. Multimodal nanogels combining ZW800-1 as an optical absorber and gadolinium chelates for multispectral optoacoustic tomography (MSOT) and magnetic resonance imaging (MRI)

Author

Chuburu, Francoise, primary, Gosee, Camille, additional, Moreau, Juliette, additional, Cadiou, Cyril, additional, Callewaert, Maite, additional, Henoumont, Céline, additional, Larbanoix, Lionel, additional, Molinari, Michael, additional, Voicu, Sorina N, additional, Portefaix, Christophe, additional, and Laurent, Sophie, additional

Published
2023
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13. List of contributors

Author

Alvarado, Yolanda, Argenta, Débora Fretes, Barbosa, Raquel de Melo, Bartel, Marta, Cadiou, Cyril, Callewaert, Maité, Caon, Thiago, Chuburu, Françoise, Danquah, Michael K., Das, Manita, Dash, Alekha K., de Paula, Eneida, Finkler, Christine Lamenha Luna, Galán, M.A., Giri, Tapan Kumar, González-Garcinuño, A., Głowala, Paulina, Illescas, Javier, Iyer, Arun K., Jana, Sougata, Jasmin, Nilofer, Jurado-Sánchez, Beatriz, Kannan, Soundarapandian, Kashaw, Sushil K., Krug, Pamela, Kwiatkowska, Marta, Lakkadwala, Sushant, Laurent, Sophie, Li, Ya, Liang, Weijie, Liu, Nan, Liu, Yanan, Malytskyi, Volodymyr, Martelli, Silvia Maria, Martín del Valle, E.M., Mazur, Maciej, Meerovich, Igor, Mojzych, Ilona, Moreau, Juliette, Muro, Claudia, Nipun Babu, V., Pacheco-Jerez, Marta, Rejeeth, Chandrababu, Riera, Francisco, Rigaux, Guillaume, Rodrigues, Bruna dos Santos, Sahu, Prashant, Sau, Samaresh, Sen, Kalyan Kumar, Severino, Patrícia, Sharma, Divya, Singh, Jagdish, Skiba, Aleksandra, Solanki, Archana, Tabernero, A., Tan, Kei X., Thakore, Sonal I., Ujan, Safina, Vivek, Raju, Wójtowicz, Agata, and Wysocka, Barbara

Published
2019
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15. Cyclam-methylbenzimidazole: a Selective OFF-ON Fluorescent Sensor for Zinc

Author

UCL - SST/IMCN/MOST - Molecules, Solids and Reactivity, El Majzoub, Abir, Cadiou, Cyril, Dechamps-Olivier, Isabelle, Tinant, Bernard, Chuburu, Francoise, UCL - SST/IMCN/MOST - Molecules, Solids and Reactivity, El Majzoub, Abir, Cadiou, Cyril, Dechamps-Olivier, Isabelle, Tinant, Bernard, and Chuburu, Francoise

Published
2011

16. Mono- and bis-N-functionalised cyclen with benzimidazolylmethyl pendant arms: Sensitive and selective fluorescent probes for zinc and copper ions

Author

UCL - SC/CHIM - Département de chimie, El Majzoub, Abir, CadiouA, Cyril, Dechamps-Olivier, Isabelle, Chuburu, Francoise, Aplincourt, Michel, Tinant, Bernard, UCL - SC/CHIM - Département de chimie, El Majzoub, Abir, CadiouA, Cyril, Dechamps-Olivier, Isabelle, Chuburu, Francoise, Aplincourt, Michel, and Tinant, Bernard

Abstract

The Zn2+ and Cu2+ complexes of L-1 and L-2 ligands (L-1: 1-(benzimidazol-2-ylmethyl)-1,4,7,10-tetraazacyclododecane, L-2: 1,7-bis(benzimidazol-2-ylmethyl)-1,4,7,10-tetraazacyclododecane) were synthesised and characterised by means of NMR, EPR, and UV-Vis spectroscopies, X-ray determination and molecular modelisation (HF-DFT(B3LYP)/LANL2DZ). These studies showed that the 1: 1 complexes were formed in which the benzimidazole arm(s) are coordinated to the metal ion. On addition of successive amounts of Zn2+ in CH3CN, the. fluorescence emission of L-1 increased linearly by a factor of 50 and the one of L-2 by a factor of 5 while on addition of successive amounts of Cu2+ in CH3CN, the. fluorescence emission of L-2 decreased linearly to 80% of its initial value. (C) 2008 Elsevier B. V. All rights reserved.

Published
2009

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