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Your search keyword '"Chua, Y. C."' showing total 23 results
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23 results on '"Chua, Y. C."'

13. Oesophageal epithelial ASIC3 is associated with increase in severity of symptoms in patients with gastro-oesophageal reflux disease (GORD)

Author

Chua, Y. C., primary, Hubball, A., additional, Peiris, M., additional, Ng, K. S., additional, Hughes, S. F., additional, Chinaleong, J., additional, Preston, S., additional, Patel, B., additional, Chaudry, A., additional, Levey, P., additional, Martin, J., additional, Aziz, Q., additional, and Knowles, C. H., additional

Published
2011
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20. Potentiodynamic studies of tin corrosion in presence of citrate and bisulphate ions in aqueous solutions of varying pH

Author

Chan, C. Y., Khoo, K. H., Chua, Y. C., and Guruswamy, S.

Abstract

Cathodic and anodic polarisation plots for the corrosion of pure tin foil and tinplate in deoxygenated aqueous solutions containing various quantities of citric acid, trisodium citrate, and sodium bisulphate have been obtained from potentiodynamic measurements. Open circuit potentials for the corrosion of tin surfaces in such solutions at 25°C become more negative with increasing pH. At sufficiently anodic potentials, in the presence of citrate ions, passivation characteristics were observed in the anodic polarisation plots when a white solid material, probably a tin citrate complex compound, formed on the electrode surface. SEM micrographs of the coated surface indicated that the solid was crystalline in nature. Cathodic Tafel slopes for the hydrogen evolution reaction on tin for the different solutions were determined.

Published
1993
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23. Perception of gastro-oesophageal reflux.

Author

Chua YC and Aziz Q

Subjects
Afferent Pathways physiopathology, Animals, Evoked Potentials, Gastroesophageal Reflux physiopathology, Gastroesophageal Reflux psychology, Heartburn physiopathology, Heartburn psychology, Humans, Hyperalgesia physiopathology, Hyperalgesia psychology, Pain physiopathology, Pain psychology, Pain Measurement, Esophagus innervation, Gastroesophageal Reflux complications, Heartburn etiology, Hyperalgesia etiology, Pain etiology
Abstract

Gastro-oesophageal reflux disease (GORD) is common and often associated with unpleasant symptoms requiring utilisation of health care resource. While in the majority of patients symptom resolution occurs with acid suppressant therapy, in a proportion this treatment is ineffective in resolving symptoms. This is particularly the case in patients with non-erosive reflux disease (NERD) and functional heartburn (FH). It is increasingly being recognised that the presence of acid in the oesophagus can cause dilated intercellular spaces (DIS) which increases the exposure of the sub-epithelial nerves to the acid. Experimental studies in both animals and humans suggest that a variety of receptors on afferent nerves can be sensitised upon exposure to acid so that there is increased afferent input to the spinal cord dorsal horn neurons which leads to a reduction in threshold of these neurons together with an increase in their receptive field. This increased sensitivity of primary afferent nerves is described as peripheral sensitisation, whereas the consequent increase in sensitivity of the spinal dorsal horn neurons is described as central sensitisation. Once these mechanisms have been established they can cause a long term increase in sensitivity of tissues to previously innocuous stimuli. Furthermore, psychological stress has been shown to increase DIS and may therefore facilitate peripheral sensitisation. Currently peripheral and central sensitisations are considered to be important mechanisms of oesophageal pain hypersensitivity and occurrence of symptoms to even physiological amounts of acid. In these patients treatments aimed at reducing neuronal sensitivity may be effective in the management., (Copyright © 2010 Elsevier Ltd. All rights reserved.)

Published
2010
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