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5. Combined therapy with shock wave and autologous bone marrow-derived mesenchymal stem cells alleviates left ventricular dysfunction and remodeling through inhibiting inflammatory stimuli, oxidative stress & enhancing angiogenesis in a swine myocardial infarction model

Author

Sheu, Jiunn-Jye, Lee, Fan-Yen, Yuen, Chun-Man, Chen, Yi-Ling, Huang, Tien-Hung, Chua, Sarah, Chen, Yung-Lung, Chen, Chih-Hung, Chai, Han-Tan, Sung, Pei-Hsun, Chang, Hsueh-Wen, Sun, Cheuk-Kwan, and Yip, Hon-Kan

Published
2015
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26. Case 20-2006: An 84-year-old man with staphylococcal bacteremia and renal failure

Author

Denton, Mark D., Digumarthy, Subba R., Chua, Sarah, and Colvin, Robert B.

Subjects
Staphylococcal infections -- Case studies, Kidney failure -- Case studies
Abstract

The case study of an 84-year-old man, who was transferred to hospital due staphylococcal bacteremia and renal failure, is presented. A day-by-day account of the patient's progress is presented together with a discussion on the diagnoses reached, namely, glomerulonephritis and acute tubular necrosis, as well as the line of treatment used.

Published
2006

44. Combination of cilostazol and clopidogrel attenuates Rat critical limb ischemia

Author

Sheu Jiunn-Jye, Lin Kun-Chen, Tsai Ching-Yen, Tsai Tzu-Hsien, Leu Steve, Yen Chia-Hung, Chen Yung-Lung, Chang Hsueh-Wen, Sun Cheuk-Kwan, Chua Sarah, Yang Jenq-Lin, and Yip Hon-Kan

Subjects
Critical limb ischemia, Apoptosis, Inflammation, Pharmacomodulation, Angiogenesis, Medicine
Abstract

Abstract Background and aim Procedural failure and untoward clinical outcomes after surgery remain problematic in critical limb ischemia (CLI) patients. This study tested a clopidogrel-cilostazol combination treatment compared with either treatment alone in attenuating CLI and improving CLI-region blood flow in rats. Methods Male Sprague–Dawley rats (n = 40) were equally divided into five groups: control, CLI induction only, CL I + cilostazol (12.0 mg/day/kg), CLI + clopidogrel (8.0 mg/kg/day) and CLI + combined cilostazol-clopidogrel. After treatment for 21 days, Laser Doppler imaging was performed. Results On day 21, the untreated CLI group had the lowest ratio of ischemic/normal blood flow (p Conclusion Combined cilostazol-clopidogrel therapy is superior to either agent alone in improving ischemia in rodent CLI.

Published
2012
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45. Effect of obesity reduction on preservation of heart function and attenuation of left ventricular remodeling, oxidative stress and inflammation in obese mice

Author

Wang Hui-Ting, Liu Chu-Feng, Tsai Tzu-Hsien, Chen Yung-Lung, Chang Hsueh-Wen, Tsai Ching-Yen, Leu Steve, Zhen Yen-Yi, Chai Han-Tan, Chung Sheng-Ying, Chua Sarah, Yen Chia-Hung, and Yip Hon-Kan

Subjects
Obesity, Inflammation, Oxidative stress, Apoptosis, Fibrosis, Medicine
Abstract

Abstract Background Obesity is an important cardiovascular risk factor. This study tested the effect of obesity reduction on preserving left ventricular ejection fraction (LVEF) and attenuating inflammation, oxidative stress and LV remodeling in obese mice. Methods and results Eight-week-old C57BL/6 J mice (n=24) were equally divided into control (fed a control diet for 22 weeks), obesity (high-fat diet, 22 weeks), and obese reduction (OR) (high-fat diet, 14 weeks; then control diet, 8 weeks). Animals were sacrificed at post 22-week high-fat diet and the LV myocardium collected. Heart weight, body weight, abdominal-fat weight, total cholesterol level and fasting blood glucose were higher in obesity than in control and OR (all p Conclusion Impaired LVEF, enhanced LV remodeling, inflammation, fibrosis, oxidative stress and apoptosis were reversed by reduction in mouse obesity.

Published
2012
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46. Impact of obesity control on circulating level of endothelial progenitor cells and angiogenesis in response to ischemic stimulation

Author

Chen Yung-Lung, Chang Chia-Lo, Sun Cheuk-Kwan, Wu Chiung-Jen, Tsai Tzu-Hsien, Chung Sheng-Ying, Chua Sarah, Yeh Kuo-Ho, Leu Steve, Sheu Jiunn-Jye, Lee Fan-Yen, Yen Chia-Hung, and Yip Hon-Kan

Subjects
Obesity control, Endothelial progenitor cells, Angiogenesis, Critical limb ischemia, Medicine
Abstract

Abstract Background and aim We tested the hypothesis that obesity reduced circulating number of endothelial progenitor cells (EPCs), angiogenic ability, and blood flow in ischemic tissue that could be reversed after obesity control. Methods 8-week-old C57BL/6J mice (n = 27) were equally divided into group 1 (fed with 22-week control diet), group 2 (22-week high fat diet), and group 3 (14-week high fat diet, followed by 8-week control diet). Critical limb ischemia (CLI) was induced at week 20 in groups 2 and 3. The animals were sacrificed at the end of 22 weeks. Results Heart weight, body weight, abdominal fat weight, serum total cholesterol level, and fasting blood sugar were highest in group 2 (all p Conclusion Obesity suppressed abilities of angiogenesis and recovery from CLI that were reversed by obesity control.

Published
2012
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47. Intra-coronary administration of tacrolimus markedly attenuates infarct size and preserves heart function in porcine myocardial infarction

Author

Chua Sarah, Leu Steve, Sheu Jiunn-Jye, Lin Yu-Chun, Chang Li-Teh, Kao Ying-Hsien, Yen Chia-Hung, Tsai Tzu-Hsien, Chen Yung-Lung, Chang Hsueh-Wen, Sun Cheuk-Kwan, and Yip Hon-Kan

Subjects
Therapeutics. Pharmacology, RM1-950
Abstract

Abstract Background We test the hypothesis that intra-coronary tacrolimus administration can limit infarct size and preserve left ventricular ejection fraction (LVEF) after acute myocardial infarction (AMI) through ligating left anterior descending coronary artery (LAD) in mini-pigs. Methods Twelve male mini-pigs were randomized into AMI-saline (MI-only) group and AMI-tacrolimus (MI-Tac) group that received intra-coronary saline (3.0 mL) and tacrolimus (0.5 mg in 2.5 mL saline) injection, respectively, beyond site of ligation 30 minutes after LAD occlusion. Results Larger infarct area was noted in MI-only group (p Conclusion Intra-coronary administration of tacrolimus significantly attenuated infarct size and preserved LV function.

Published
2012
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48. Comparison of acute versus convalescent stage high-sensitivity C-Reactive protein level in predicting clinical outcome after acute ischemic stroke and impact of erythropoietin

Author

Yeh Kuo-Ho, Tsai Tzu-Hsien, Chai Han-Tan, Leu Steve, Chung Sheng-Ying, Chua Sarah, Chen Yung-Lung, Lin Hung-Sheng, Yuen Chun-Man, and Yip Hon-Kan

Subjects
acute ischemic stroke, high-sensitivity C-reactive protein, erythropoietin, adverse clinical outcome, Medicine
Abstract

Abstract Background and Aim Currently, no data on the optimal time point after acute ischemic stroke (IS) at which high-sensitivity C-reactive protein (hs-CRP) level is most predictive of unfavorable outcome. We tested the hypothesis that hs-CRP levels during both acute (48 h after IS) and convalescent (21 days after IS) phases are equally important in predicting 90-day clinical outcome after acute IS. We further evaluated the impact of erythropoietin (EPO), an anti-inflammatory agent, on level of hs-CRP after acute IS. Methods Totally 160 patients were prospectively randomized to receive either EPO therapy (group 1, n = 80) (5,000 IU each time, subcutaneously) at 48 h and 72 h after acute IS, or placebo (group 2, n = 80). Serum level of hs-CRP was determined using ELISA at 48 h and on day 21 after IS and once in 60 healthy volunteers. Results Serum level of hs-CRP was substantially higher in all patients with IS than in healthy controls at 48 h and day 21 after IS (all p < 0.001). Levels of hs-CRP did not differ between group 1 and 2 at 48 h and day 21 after IS (all p > 0.5). Multivariate analysis showed that hs-CRP levels (at 48 h and day 21) were independently predictive of 90-day major adverse neurological event (MANE) (defined as recurrent stroke, NIHSS≥8, or death) (all p < 0.03), whereas EPO therapy was independently predictive of reduced 90-day MANE (all p < 0.02). Conclusion EPO therapy which was independently predictive of freedom from 90-day MANE did not alter the crucial role of hs-CRP levels measured at 48 h and 21-day in predicting unfavorable clinical outcome after IS.

Published
2012
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49. Role of double knockdown of tPA and MMP-9 on regulating the left ventricular function and remodeling followed by transverse aortic constriction-induced hypertrophic cardiomyopathy in mice

Author

Sung, Pei-Hsun, Chua, Sarah, Chen, Kuan-Hung, Sun, Cheuk-Kwan, Li, Yi-Chen, Huang, Chi-Ruei, Luo, Chi-Wen, Chai, Han-Tan, Lu, Hung-I, and Yip, Hon-Kan

Subjects
Original Article
Abstract

This study tested the hypothesis that extracellular matrix accumulation in tPA-/-/MMP-9-/- [double-knockout (DKO)] may be protective against left ventricular (LV) remodeling and dysfunction following transverse aortic constriction (TAC)-induced hypertrophic cardiomyopathy in mice. Wild-type C57BL/6 mice (n = 20) were equally categorized into sham-control (SC1) and TAC1. Similarly, DKO mice (n = 20) were equally divided into two groups (i.e., SC2 and ATC2). By days 28/60 after TAC, LV ejection fraction (LVEF) was significantly higher in TAC2 than TAC1, whereas LV end-systolic/diastolic dimensions displayed an opposite pattern to LVEF between the two groups (all P < 0.05). By day 90, LVEF was significantly higher in SC groups than that in TAC1 and TAC2 without notable difference between the latter two groups, whereas LV end-systolic/diastolic dimensions, cardiomyocyte size and right-ventricular systolic pressure showed an opposite pattern compared with LVEF in all groups (all P < 0.01). Total heart weight was highest in TAC1 and significantly higher in TAC2 than those in the SC groups (P < 0.01). LV myocardial protein expressions of inflammation (TNF-α/NF-κβ), apoptosis (mitochondrial-Bax/cleaved caspase-3/PARP), oxidative stress (NOX-1/NOX-2/oxidized protein), fibrosis (Smad3/TGF-β), DNA/mitochondrial damage (γ-H2AX/cytosolic-cytochrome-C) and LV hypertrophy/pressure-overload (β-MHC/BNP) biomarkers were significantly increased in TAC2 compared to TAC1 and SC groups, and significantly increased in TAC1 compared to SC groups (all P < 0.001). Histopathology demonstrated that the fibrotic/collagen-deposition areas and sarcomere length exhibited an identical pattern to inflammation among the four groups (all P < 0.0001). In conclusion, although tPA-/-/MMP-9-/- seemed to preserve cardiac function in an experimental setting of hypertrophic cardiomyopathy at an early stage, it failed to exert long-term protective effect.

Published
2018

50. Corrigendum to “The therapeutic effect of rosuvastatin and propylthiouracil on ameliorating high-cholesterol diet-induced rabbit aortic atherosclerosis and stiffness” [Int. J. Cardiol. 227 (2017) 938–949]

Author

Lin, Pao-Yuan, primary, Lee, Fan-Yen, additional, Wallace, Christopher Glenn, additional, Chen, Kuan-Hung, additional, Kao, Gour-Shenq, additional, Sung, Pei-Hsun, additional, Chua, Sarah, additional, Ko, Sheung-Fat, additional, Chen, Yung-Lung, additional, Wu, Shun-Cheng, additional, Chang, Hsueh-Wen, additional, Yip, Hon-Kan, additional, and Shao, Pei-Lin, additional

Published
2019
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