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10 results on '"Chua, Khi Pin"'

1. A multimodal atlas of hepatocellular carcinoma reveals convergent evolutionary paths and ‘bad apple’ effect on clinical trajectory

Author

Chen, Jianbin, Kaya, Neslihan Arife, Zhang, Ying, Kendarsari, Raden Indah, Sekar, Karthik, Lee Chong, Shay, Seshachalam, Veerabrahma Pratap, Ling, Wen Huan, Jin Phua, Cheryl Zi, Lai, Hannah, Yang, Hechuan, Lu, Bingxin, Lim, Jia Qi, Ma, Siming, Chew, Sin Chi, Chua, Khi Pin, Santiago Alvarez, Jacob Josiah, Wu, Lingyan, Ooi, London, Yaw-Fui Chung, Alexander, Cheow, Peng Chung, Kam, Juinn Huar, Wei-Chieh Kow, Alfred, Ganpathi, Iyer Shridhar, Bunchaliew, Chairat, Thammasiri, Jidapa, Koh, Peng Soon, Bee-Lan Ong, Diana, Lim, Jasmine, de Villa, Vanessa H., Dela Cruz, Rouchelle D., Loh, Tracy Jiezhen, Wan, Wei Keat, Leow, Wei Qiang, Yang, Yi, Liu, Jin, Skanderup, Anders Jacobsen, Pang, Yin Huei, Ting Soon, Gwyneth Shook, Madhavan, Krishnakumar, Kiat-Hon Lim, Tony, Bonney, Glenn, Goh, Brian K.P., Chew, Valerie, Dan, Yock Young, Toh, Han Chong, Sik-Yin Foo, Roger, Tam, Wai Leong, Zhai, Weiwei, and Kah-Hoe Chow, Pierce

Published
2024
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2. Characterization and visualization of tandem repeats at genome scale

Author

Dolzhenko, Egor, primary, English, Adam, additional, Dashnow, Harriet, additional, De Sena Brandine, Guilherme, additional, Mokveld, Tom, additional, Rowell, William J., additional, Karniski, Caitlin, additional, Kronenberg, Zev, additional, Danzi, Matt C., additional, Cheung, Warren A., additional, Bi, Chengpeng, additional, Farrow, Emily, additional, Wenger, Aaron, additional, Chua, Khi Pin, additional, Martínez-Cerdeño, Verónica, additional, Bartley, Trevor D., additional, Jin, Peng, additional, Nelson, David L., additional, Zuchner, Stephan, additional, Pastinen, Tomi, additional, Quinlan, Aaron R., additional, Sedlazeck, Fritz J., additional, and Eberle, Michael A., additional

Published
2024
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3. Supplementary Data from Integrative Profiling of T790M-Negative EGFR-Mutated NSCLC Reveals Pervasive Lineage Transition and Therapeutic Opportunities

Author

Chua, Khi Pin, primary, Teng, Yvonne H.F., primary, Tan, Aaron C., primary, Takano, Angela, primary, Alvarez, Jacob J.S., primary, Nahar, Rahul, primary, Rohatgi, Neha, primary, Lai, Gillianne G.Y., primary, Aung, Zaw Win, primary, Yeong, Joe P.S., primary, Lim, Kiat Hon, primary, Naeini, Marjan Mojtabavi, primary, Kassam, Irfahan, primary, Jain, Amit, primary, Tan, Wan Ling, primary, Gogna, Apoorva, primary, Too, Chow Wei, primary, Kanesvaran, Ravindran, primary, Ng, Quan Sing, primary, Ang, Mei Kim, primary, Rajasekaran, Tanujaa, primary, Anantham, Devanand, primary, Phua, Ghee Chee, primary, Tan, Bien Soo, primary, Lee, Yin Yeng, primary, Wang, Lanying, primary, Teo, Audrey S.M., primary, Khng, Alexis Jiaying, primary, Lim, Ming Jie, primary, Suteja, Lisda, primary, Toh, Chee Keong, primary, Lim, Wan-Teck, primary, Iyer, N. Gopalakrishna, primary, Tam, Wai Leong, primary, Tan, Eng-Huat, primary, Zhai, Weiwei, primary, Hillmer, Axel M., primary, Skanderup, Anders J., primary, and Tan, Daniel S.W., primary

Published
2023
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4. Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma: the PLANET study

Author

Zhai, Weiwei, primary, Lai, Hannah, additional, Kaya, Neslihan Arife, additional, Chen, Jianbin, additional, Yang, Hechuan, additional, Lu, Bingxin, additional, Lim, Jia Qi, additional, Ma, Siming, additional, Chew, Sin Chi, additional, Chua, Khi Pin, additional, Alvarez, Jacob Josiah Santiago, additional, Chen, Pauline Jieqi, additional, Chang, Mei Mei, additional, Wu, Lingyan, additional, Goh, Brian K P, additional, Chung, Alexander Yaw-Fui, additional, Chan, Chung Yip, additional, Cheow, Peng Chung, additional, Lee, Ser Yee, additional, Kam, Juinn Huar, additional, Kow, Alfred Wei-Chieh, additional, Ganpathi, Iyer Shridhar, additional, Chanwat, Rawisak, additional, Thammasiri, Jidapa, additional, Yoong, Boon Koon, additional, Ong, Diana Bee-Lan, additional, de Villa, Vanessa H, additional, Dela Cruz, Rouchelle D, additional, Loh, Tracy Jiezhen, additional, Wan, Wei Keat, additional, Zeng, Zeng, additional, Skanderup, Anders Jacobsen, additional, Pang, Yin Huei, additional, Madhavan, Krishnakumar, additional, Lim, Tony Kiat-Hon, additional, Bonney, Glenn, additional, Leow, Wei Qiang, additional, Chew, Valerie, additional, Dan, Yock Young, additional, Tam, Wai Leong, additional, Toh, Han Chong, additional, Foo, Roger Sik-Yin, additional, and Chow, Pierce Kah-Hoe, additional

Published
2021
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5. Integrative Profiling of T790M-Negative EGFR-Mutated NSCLC Reveals Pervasive Lineage Transition and Therapeutic Opportunities

Author

Chua, Khi Pin, primary, Teng, Yvonne H.F., additional, Tan, Aaron C., additional, Takano, Angela, additional, Alvarez, Jacob J.S., additional, Nahar, Rahul, additional, Rohatgi, Neha, additional, Lai, Gillianne G.Y., additional, Aung, Zaw Win, additional, Yeong, Joe P.S., additional, Lim, Kiat Hon, additional, Naeini, Marjan Mojtabavi, additional, Kassam, Irfahan, additional, Jain, Amit, additional, Tan, Wan Ling, additional, Gogna, Apoorva, additional, Too, Chow Wei, additional, Kanesvaran, Ravindran, additional, Ng, Quan Sing, additional, Ang, Mei Kim, additional, Rajasekaran, Tanujaa, additional, Anantham, Devanand, additional, Phua, Ghee Chee, additional, Tan, Bien Soo, additional, Lee, Yin Yeng, additional, Wang, Lanying, additional, Teo, Audrey S.M., additional, Khng, Alexis Jiaying, additional, Lim, Ming Jie, additional, Suteja, Lisda, additional, Toh, Chee Keong, additional, Lim, Wan-Teck, additional, Iyer, N. Gopalakrishna, additional, Tam, Wai Leong, additional, Tan, Eng-Huat, additional, Zhai, Weiwei, additional, Hillmer, Axel M., additional, Skanderup, Anders J., additional, and Tan, Daniel S.W., additional

Published
2021
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6. Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma: the PLANET study.

Author

Zhai, Weiwei, Lai, Hannah, Kaya, Neslihan Arife, Chen, Jianbin, Yang, Hechuan, Lu, Bingxin, Lim, Jia Qi, Ma, Siming, Chew, Sin Chi, Chua, Khi Pin, Alvarez, Jacob Josiah Santiago, Chen, Pauline Jieqi, Chang, Mei Mei, Wu, Lingyan, Goh, Brian K P, Chung, Alexander Yaw-Fui, Chan, Chung Yip, Cheow, Peng Chung, Lee, Ser Yee, and Kam, Juinn Huar

Subjects
HEPATOCELLULAR carcinoma, PHENOTYPES, HETEROGENEITY, RNA, OVERALL survival
Abstract

Intra-tumor heterogeneity (ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic (transcriptomic and immune) heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma (HCC) with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients (331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage II patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types. [ABSTRACT FROM AUTHOR]

Published
2022
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7. Genomic landscape of lung adenocarcinoma in East Asians

Author

Chen, Jianbin, primary, Yang, Hechuan, additional, Teo, Audrey Su Min, additional, Amer, Lidyana Bte, additional, Sherbaf, Faranak Ghazi, additional, Tan, Chu Quan, additional, Alvarez, Jacob Josiah Santiago, additional, Lu, Bingxin, additional, Lim, Jia Qi, additional, Takano, Angela, additional, Nahar, Rahul, additional, Lee, Yin Yeng, additional, Phua, Cheryl Zi Jin, additional, Chua, Khi Pin, additional, Suteja, Lisda, additional, Chen, Pauline Jieqi, additional, Chang, Mei Mei, additional, Koh, Tina Puay Theng, additional, Ong, Boon-Hean, additional, Anantham, Devanand, additional, Hsu, Anne Ann Ling, additional, Gogna, Apoorva, additional, Too, Chow Wei, additional, Aung, Zaw Win, additional, Lee, Yi Fei, additional, Wang, Lanying, additional, Lim, Tony Kiat Hon, additional, Wilm, Andreas, additional, Choi, Poh Sum, additional, Ng, Poh Yong, additional, Toh, Chee Keong, additional, Lim, Wan-Teck, additional, Ma, Siming, additional, Lim, Bing, additional, Liu, Jin, additional, Tam, Wai Leong, additional, Skanderup, Anders Jacobsen, additional, Yeong, Joe Poh Sheng, additional, Tan, Eng-Huat, additional, Creasy, Caretha L., additional, Tan, Daniel Shao Weng, additional, Hillmer, Axel M., additional, and Zhai, Weiwei, additional

Published
2020
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10. Dilated aorta in CNOT3 -related neurodevelopmental disorder: 'expanding' the phenotype.

Author

Lau SHM, Jiin Ying L, Goh CYJ, Choo J, Chow C, Ling S, Ng YH, Yi Hua T, Teo JX, Chua KP, Chin M, Lim WK, Jamuar SS, Lai AHM, and Goh JLK

Subjects
Humans, Female, Genetic Association Studies, Aorta pathology, Genetic Predisposition to Disease, Phenotype, Transcription Factors genetics, Neurodevelopmental Disorders genetics, Neurodevelopmental Disorders diagnosis
Abstract

Introduction: Neurodevelopmental disorders (NDDs) comprise conditions that emerge during the child's development and contribute significantly to global health and economic burdens. De novo variants in CNOT3 have been linked to NDDs and understanding the genotype-phenotype relationship between CNOT3 and NDDs will aid in improving diagnosis and management., Methods: In this study, we report a case of a patient with CNOT3 -related NDD who presented with progressive aortic dilatation, a feature not reported previously., Results: Our patient presented with intellectual disorder, dysmorphic facial features, and cardiac anomalies, notably progressive aortic dilatation - a novel finding in CNOT3 -related NDD. Genetic testing identified a de novo 6.3 kbp intragenic deletion in CNOT3 , providing a possible genetic basis for her condition., Conclusion: This study presents the first case of CNOT3 -related NDD in Southeast Asia, expanding the phenotype to include progressive aortic dilatation and suggesting merit in cardiac surveillance of patients with CNOT3 -related NDD. It also emphasizes the importance of genetic testing in diagnosing complex NDD cases as well as reanalysis of 'negative' cases using advanced sequencing technologies to uncover potential hidden genetic etiologies in undiagnosed NDDs., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)

Published
2024
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