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To observe the effect of acupuncture technique ofA total of 24 male SD rats were randomly divided into a sham operation group, a model group, a medication group and an acupuncture group after Morris water maze test, 6 rats in each group. VD model was established by permanent ligation of bilateral common carotid arteries in the model group, the medication group and the acupuncture group. Treatment was given on the next day after successful modeling. The rats in the acupuncture group were treated with acupuncture at "Baihui" (GV 20), "Shenting" (GV 24), "Shuigou" (GV 26), "Dazhui" (GV 14), "Fengfu" (GV 16), "Mingmen" (GV 4), "Neiguan" (PC 6), "Daling" (PC 7) and "Laogong" (PC 8) for 30 min; the rats in the medication group were treated with nimodipine solution (0.0625 g/kg) by gavage, once a day, for 2 weeks. Morris water maze test was used to detect the behavior of rats before modeling, 2 weeks after modeling and after intervention; after intervention, the expressions of VEGF and Ang-1 protein in hippocampus were detected by Western blot.Compared with the sham operation group, the average escape latency of rats in the model group was prolonged (The acupuncture technique of

To investigate the effect of acupuncture plus mild hypothermia on neurological function impairment score, cerebral infarct size and apoptosis-related factors in cerebral ischemia reperfusion injury (CIRI) rats. Sixty healthy male Sprague-Dawley (SD) rats were routinely reared for 1 week. Ten rats were randomly selected as the sham operation group and 10 rats as the blank control group, while the remaining 40 rats were subjected to preparing the middle cerebral artery occlusion (MCAO) model by modified filament occlusion method. The 40 MCAO rats were further randomly divided into a model group, an acupuncture group, a mild hypothermia group and an acupuncture plus mild hypothermia group, with 10 rats in each group. Rats in the sham operation group, the blank control group and the model group did not accept treatment except binding; rats in the acupuncture group received acupuncture treatment; rats in the mild hypothermia group received mild hypothermia treatment; rats in the acupuncture plus mild hypothermia group received acupuncture and mild hypothermia treatment. 72 h after the treatment, neurological function impairment score was performed; the infarct area ratio was determined by 2,3,5-tripheyl tetrazolium chloride (TTC) staining; apoptosis of brain cells was observed by TUNEL method; the expressions of Bcl-2, Bax and Caspase-3 were detected by immunohistochemistry. Compared with the blank control group and the sham operation group, the neurological function impairment score, cerebral infarct area ratio, apoptosis, and the expressions of Bax and Caspase-3 in the model group were significantly increased, while the expression of Bcl-2 was significantly decreased, and there were significant between-group differences (all P

Background: Aging leads to loss of muscle mass causing functional limitation and reduced quality of life. Myopenia is a new universal term for the presence of clinically relevant muscle wasting. However, little is known about the prevalence of myopenia in elderly rheumatoid arthritis (RA) patients and its influence on RA pathogenesis and disease characteristics. We aimed to explore the characteristics of muscle mass and distribution and their clinical significance. Methods: Consecutive RA patients were recruited and clinical data including disease activity (DAS28-CRP), physical function (health assessment questionnaire disability index, HAQ-DI) and radiographic indicators (modified Sharp score) were collected. The muscle mass and distribution were assessed by bioelectric impedance analysis. Myopenia was defined as appendicular skeletal muscle mass index (ASMI) ≤7.0kg/m2 (men) and ≤5.7kg/m2 (women). Results: Among 643 RA patients recruited, there were 165 (25.7%) elderly patients (age≥60 years) with mean age 65.1±4.5 years. Compared with young patients (age

Supplemental material, Supplementary_Table_S1_revised for Reduced skeletal muscle independently predicts 1-year aggravated joint destruction in patients with rheumatoid arthritis by Jian-Zi Lin, Yin Liu, Jian-Da Ma, Ying-Qian Mo, Chu-Tao Chen, Le-Feng Chen, Qian-Hua Li, Ze-Hong Yang, Dong-Hui Zheng, Li Ling, Pierre Miossec and Lie Dai in Therapeutic Advances in Musculoskeletal Disease

Supplemental material, sj-pdf-1-taj-10.1177_2040622320975241 for Neglected extra-articular manifestations in rheumatoid arthritis patients with normal body mass index: reduced skeletal muscle overlapping overfat by Jian-Zi Lin, Chu-Tao Chen, Jian-Da Ma, Ying-Qian Mo, Qian-Hua Li, Le-Feng Chen, Ze-Hong Yang, Wan-Mei Cheng, Xiao-Ling He, Dong-Hui Zheng and Lie Dai in Therapeutic Advances in Chronic Disease

To observe the effect of acupuncture on changes of neurological function and expression of proteins in the ischemic brain region in middle cerebral artery occlusion (MCAO) rats with protein chip technique, so as to reveal the profiles of cerebral proteins related to its effectiveness in improving cerebral ischemia (CI).SD rats were rando-mized into sham operation (sham), CI model, non-acupoint and acupoint groups (Compared with the sham group, the neurological deficit score was significantly higher in the model group (Manual acupuncture stimulation of GV 14, GV 20 and GV 26 can improve neurological function in CI rats, which may be associated with its function in regulating the expression of many proteins in the ischemic region of the brain.

In recent years, both the city scale and economic level grow rapidly in China. Urbanization and motorization bring heavy pressure on the land, energy, transport and the environment. Thinking and exploring more rational traffic patterns to resolve the adverse effect on urbanization and motorization is an essential way to achieve sustainable development of urban transportation. As a kind of public transport, the effective convergence between bicycle and urban rail transit would help our transportation mode transfer from ‘sites – sites’ toward ‘door – door’ so as to establish an efficient system of transport links and ease traffic pressure. This article is about the analysis and evaluation of feasibility and connectivity features of bike-and-ride at urban rail transit station of Huizhou city in PR China. And then provides valuable references for decision-making of related departments.

Objective To probe into the mechanisms of electroacupuncture (EA) at Shangjuxu (ST 37) for treatment of the ulcerative colitis (UC). Methods Forty male Wistar rats were randomly divided into 4 groups: a normal group, a model group, a Shangjuxu group and a non-acupoint group, 10 rats in each group. The UC rat model was made with enema of trinitro-benzenesulfonic acid (TNBSA), and the changes of interleukin-1β (IL-1β) and interleukin-4 (IL-4) contents after EA at Shangjuxu (ST 37) were observed. Results EA at Shangjuxu (ST 37) could significantly decrease the IL-1β content and increase the IL-4 content in the colic tissues of the UC rats with significant differences as compared with the model group and the non-acupoint group ( P P Conclusion The mechanisms of EA at Shangjuxu (ST 37) for treatment of the UC rats is possibly related with the decrease of IL-1β, a inflammation-promoting cytokine, and the increase of IL-4, a anti-inflammatory cytokine.

To systematically evaluate acupuncture as a treatment for male infertility.We searched Chi na Biology Medical Database (CBM), Wan Fang Medical Information System, China National Knowledge Infrastructure (CNKI), VIP Information Resource System (VIP), and PubMed for published literature on acupuncture as a treatment for male infertility on May 1 2014. Based on the Standards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA), we evaluated the quality of the reports, conducted meta-analysis on the identified studies via RevMan5.2, and assessed the quality of the evidence in the literature by Grading of Recommendations Assessment, Development, and Evaluation (GRADE).A total of 12 studies involving 2,177 patients were included, the quality of which was evaluated as mediocre. With regard to the cure rate, acupuncture was comparable to traditional Chinese medicine (TCM) (P0.05) but better than Western medicine (RR = 4.00, 95% CI 1.63 to 9.82, P0.01) while acupuncture + TCM was better than either TCM (RR = 1.77, 95% CI 1.20 to 2.60, P0.01) or Western medicine used alone (RR = 2.73, 95% CI 1.51 to 4.93, P0.01), and acupuncture + Western medicine was better than Western medicine alone (RR = 1.88, 95% CI 1.17 to 3.02, P = 0.01). The combined use of acupuncture, ear pressure, TCM, and Western medicine showed a higher cure rate than the combination of TCM and Western medicine (RR = 3.45, 95% CI 2.90 to 4.11, P0.01). In therapeutic effectiveness, acupuncture was comparable to TCM (P0.05) but superior to Western medicine (RR = 1.41, 95% CI 1.12 to 1.71, P0.01), acupuncture + TCM was superior to either TCM (RR = 1.14, 95% CI 1.05 to 1.23, P0.01) or Western medicine alone (RR = 1.43, 95% CI 1.22 to 1.67, P0.01), and acupuncture + Western medicine was superior to Western medicine alone (RR = 1.25, 95% CI 1.05 to 1.49, P = 0.01). In improving sperm concentration, acupuncture was as effective as TCM (P0.05) and sham acupuncture (P0.05) but outdid Western medicine (RR = 27.00, 95% CI 24.27 to 29.73, P0.01) and acupuncture + TCM outdid either TCM (RR = 14.65, 95% CI 7.58 to 21.72, P0.01) or Western medicine alone (RR = 1.04, 95% CI--1.43 to 3.51, P0.05). In improving grade a sperm, acupuncture exhibited a similar effect to TCM (P0.05) and sham acupuncture (P0.05), and acupuncture + TCM was more effective than TCM alone (RR = 7.78, 95% CI 3.51 to 12.23, P0.01) but equally effective as Western medicine (P0.05). In elevating the level of grade a + b sperm, acupuncture + TCM excelled either TCM (RR = 11.00, 95%, CI 3.17 to 18.82, P0.01) or Western medicine alone (RR = 12.22, 95% CI 6.87 to 17.57, P0. 01), while acupuncture produced a comparable effect with sham acupuncture (P0.05). As for the quality of the included studies, only 3 conclusions of the 23 meta-analyses were assessed to be of average quality, while the others of poor or extremely poor quality. Therefore, the recommendation grade of the conclusions was low.For the treatment of male infertility, acupuncture is reported to be equally effective as TMC and more effective than Western medicine, and its effectiveness is enhanced when applied in combination with either TCM or Western medicine. Acupuncture is distinctively efficacious in improving sperm quality. Nevertheless, the overall quality of the included studies is low.