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125 results on '"Chu, Yi-Min"'

11. Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease

Author

Chen Shih-Yuan, Chen Ta-Fu, Lai Liang-Chuan, Chen Jen-Hau, Sun Yu, Wen Li-Li, Yip Ping-Keung, Chu Yi-Min, and Chen Yen-Ching

Subjects
IL-6, SNP, Haplotype, Alzheimer's disease, Inflammation, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background Interleukin 6 (IL-6) has been related to beta-amyloid aggregation and the appearance of hyperphosphorylated tau in Alzheimer's disease (AD) brain. However, previous studies relating IL-6 genetic polymorphisms to AD included few and unrepresentative single nucleotide polymorphisms (SNPs) and the results were inconsistent. Methods This is a case-control study. A total of 266 patients with AD, aged≧65, were recruited from three hospitals in Taiwan (2007-2010). Controls (n = 444) were recruited from routine health checkups and volunteers of the hospital during the same period of time. Three common IL-6 haplotype-tagging SNPs were selected to assess the association between IL-6 polymorphisms and the risk of late-onset AD (LOAD). Results Variant carriers of IL-6 rs1800796 and rs1524107 were significantly associated with a reduced risk of LOAD [(GG + GC vs. CC): adjusted odds ratio (AOR) = 0.64 and (CC + CT vs. TT): AOR = 0.60, respectively]. Haplotype CAT was associated with a decreased risk of LOAD (0 and 1 copy vs. 2 copies: AOR = 0.65, 95% CI = 0.44-0.95). These associations remained significant in ApoE e4 non-carriers only. Hypertension significantly modified the association between rs2069837 polymorphisms and the risk of LOAD (pinteraction = 0.03). Conclusions IL-6 polymorphisms are associated with reduced risk of LOAD, especially in ApoE e4 non-carriers. This study identified genetic markers for predicting LOAD in ApoE e4 non-carriers.

Published
2012
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13. Performance Metrics for Selecting Single Nucleotide Polymorphisms in Late-onset Alzheimer’s Disease

Author

Chen, Yen-Ching, primary, Hsiao, Chi-Jung, additional, Jung, Chien-Cheng, additional, Hu, Hui-Han, additional, Chen, Jen-Hau, additional, Lee, Wen-Chung, additional, Chiou, Jeng-Min, additional, Chen, Ta-Fu, additional, Sun, Yu, additional, Wen, Li-Li, additional, Yip, Ping-Keung, additional, Chu, Yi-Min, additional, Chen, Chien-Jen, additional, and Yang, Hwai-I, additional

Published
2016
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15. P3-081: Application of Clinical-Based Indices on Identification of Genetic Markers for Late-Onset Alzheimer’s Disease

Author

Chen, Yen-Ching, primary, Hsiao, Chi-Jung, additional, Jung, Chien-Cheng, additional, Hu, Hui-Han, additional, Chen, Jen-Hau, additional, Lee, Wen-Chung, additional, Chiou, Jeng-Min, additional, Chen, Ta-Fu, additional, Sun, Yu, additional, Wen, Li-Li, additional, Yip, Ping-Keung, additional, Chu, Yi-Min, additional, Chen, Chien-Jen, additional, and Yang, Hwai-I., additional

Published
2016
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34. Genetic polymorphisms of nerve growth factor receptor (NGFR) and the risk of Alzheimer's disease

Author

Cheng, Hui-Chi, primary, Sun, Yu, additional, Lai, Liang-Chuan, additional, Chen, Shih-Yuan, additional, Lee, Wen-Chung, additional, Chen, Jen-Hau, additional, Chen, Ta-Fu, additional, Chen, Hua-Hsiang, additional, Wen, Li-Li, additional, Yip, Ping-Keung, additional, Chu, Yi-Min, additional, Chen, Wei J, additional, and Chen, Yen-Ching, additional

Published
2012
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36. P1‐221: Evaluating Epistatic Interactions in Alzheimer's Disease Using Multifactor Dimensionality Reduction and Entropy‐Based Estimation

Author

Huang, Ming‐Shan, primary, Chen, Yen‐Ching, additional, Huang, Yi‐Ling, additional, Chen, Jen‐Hau, additional, Chen, Ying‐Ping, additional, Lin, Yen‐Ling, additional, Cheng, Hui‐Chi, additional, Lin, Kun‐Pei, additional, Chen, Ta‐Fu, additional, Sun, Yu, additional, Yip, Ping‐Keung, additional, Wen, Li‐Li, additional, and Chu, Yi‐Min, additional

Published
2011
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39. Genetic Polymorphisms of a Novel Vascular Susceptibility Gene, Ninjurin2 (NINJ2), Are Associated with a Decreased Risk of Alzheimer's Disease

Author

Lin, Kun-Pei, primary, Chen, Shih-Yuan, additional, Lai, Liang-Chuan, additional, Huang, Yi-Ling, additional, Chen, Jen-Hau, additional, Chen, Ta-Fu, additional, Sun, Yu, additional, Wen, Li-Li, additional, Yip, Ping-Keung, additional, Chu, Yi-Min, additional, Chen, Wei J., additional, and Chen, Yen-Ching, additional

Published
2011
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43. CHRNA7 Polymorphisms and Response to Cholinesterase Inhibitors in Alzheimer's Disease.

Author

Weng, Pei-Hsuan, Chen, Jen-Hau, Chen, Ta-Fu, Sun, Yu, Wen, Li-Li, Yip, Ping-Keung, Chu, Yi-Min, and Chen, Yen-Ching

Subjects
GENETIC polymorphisms, CHOLINESTERASE inhibitors, ALZHEIMER'S disease, NICOTINIC acetylcholine receptors, NEURAL transmission, SINGLE nucleotide polymorphisms
Abstract

Background: CHRNA7 encodes the α7 nicotinic acetylcholine receptor subunit, which is important to Alzheimer's disease (AD) pathogenesis and cholinergic neurotransmission. Previously, CHRNA7 polymorphisms have not been related to cholinesterase inhibitors (ChEI) response. Methods: Mild to moderate AD patients received ChEIs were recruited from the neurology clinics of three teaching hospitals from 2007 to 2010 (n = 204). Nine haplotype-tagging single nucleotide polymorphisms of CHRNA7 were genotyped. Cognitive responders were those showing improvement in the Mini-Mental State Examination score ≧2 between baseline and 6 months after ChEI treatment. Results: AD women carrying rs8024987 variants [GG+GC vs. CC: adjusted odds ratio (AOR) = 3.62, 95% confidence interval (CI) = 1.47–8.89] and GG haplotype in block1 (AOR = 3.34, 95% CI = 1.38–8.06) had significantly better response to ChEIs (false discovery rate <0.05). These variant carriers using galantamine were 11 times more likely to be responders than female non-carriers using donepezil or rivastigmine. Conclusion: For the first time, this study found a significant association between CHRNA7 polymorphisms and better ChEI response. If confirmed by further studies, CHRNA7 polymorphisms may aid in predicting ChEI response and refining treatment choice. [ABSTRACT FROM AUTHOR]

Published
2013
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49. Construction and Preliminary Study of Tunable Dye Laser

Author

FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO, Chu,Yi-min, Shih,Chien-ping, Yen,Hsiao-pai, FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO, Chu,Yi-min, Shih,Chien-ping, and Yen,Hsiao-pai

Abstract

Edited trans. of Acta Scientiarum Naturalium Universitatis Sunyatseni (China) n3 p46-48 1976, by H. P. Lee.

Published
1978

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