22 results on '"Chu, Ke-Dan"'
Search Results
2. Cryptotanshinone ameliorates dextran sulfate sodium-induced murine acute and chronic ulcerative colitis via suppressing STAT3 activation and Th17 cell differentiation
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Fan, Li-Ming, primary, Zhang, Yu-Qin, additional, Chen, Ya-Ping, additional, Chen, Lin-Lin, additional, Xu, Wei-Heng, additional, Nan, Li-Hong, additional, Xu, Wei, additional, Lu, Bin, additional, Wang, Yan, additional, Chu, Ke-Dan, additional, and Zhang, Jun-Ping, additional
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- 2022
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3. Polydatin alleviates DSS- and TNBS-induced colitis by suppressing Th17 cell differentiation via directly inhibiting STAT3.
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Liu, Yao‐Jun, Xu, Wei‐Heng, Fan, Li‐Ming, Zhang, Yu‐Qin, Xu, Wen, Chen, Ya‐Ping, Chen, Lin‐Lin, Chen, Li, Xu, Wei, Wang, Yan, Chu, Ke‐Dan, Zhang, Jun‐Ping, Liu, Yao-Jun, Xu, Wei-Heng, Fan, Li-Ming, Zhang, Yu-Qin, Chen, Ya-Ping, Chen, Lin-Lin, Chu, Ke-Dan, and Zhang, Jun-Ping
- Abstract
Inflammatory bowel disease (IBD) is a non-specific chronic intestinal inflammatory disease, often presenting with abdominal pain, diarrhea, bloody stool, anorexia, and body loss. It is difficult to cure completely and a promising treatment is urgently needed. Natural compounds can offer promising chemical agents for treatment of diseases. Polydatin is a natural ingredient extracted from the dried rhizome of Polygonum cuspidatum, which has anti-inflammatory, anti-tumor, and dementia protection activities. The purpose of this study was to evaluate the therapeutic effect of polydatin on IBD and explore its possible mechanism. We found that polydatin could effectively suppress the differentiation of Th17 cells in vitro, but had no effect on the differentiation of Treg cells. Polydatin significantly alleviated colitis induced by dextran sulfate sodium (DSS) and 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) in mice, and dramatically decreased the proportion of Th17 cells in spleen and mesenteric lymph nodes. Mechanism investigations revealed that polydatin specifically inhibited signal transducer and activator of transcription 3 (STAT3) phosphorylation by directly binding to STAT3, leading to Th17 cell reduction and thereby alleviating colitis. These findings provide novel insights into the anti-colitis effect of polydatin, which may be a promising drug candidate for the treatment of IBD. [ABSTRACT FROM AUTHOR]
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- 2022
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4. Toxicity features of high glucose on endothelial cell cycle and protection by Dan Gua-Fang (丹瓜方) in ECV-304 in high glucose medium
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Heng, Xian-pei / 衡先培, Chen, Ke-ji / 陈可冀, Hong, Zhen-feng / 洪振丰, He, Wei-dong / 何卫东, Chu, Ke-dan / 褚克丹, Lin, Jiu-mao / 林久茂, Zheng, Hai-xia / 郑海霞, Yang, Liu-qing / 杨柳清, Huang, Su-ping / 黄苏萍, Lan, Yuan-long / 蓝元隆, Chen, Ling / 陈 玲, and Guo, Fang / 郭 芳
- Published
- 2013
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5. Anticolchicine cytotoxicity enhanced by Dan Gua-Fang (丹瓜方), a Chinese herb prescription in ECV304 in mediums
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Heng, Xian-pei / 衡先培, Chen, Ke-ji / 陈可冀, Hong, Zhen-feng / 洪振丰, He, Wei-dong / 何卫东, Chu, Ke-dan / 褚克丹, Chen, Wen-lie / 陈文列, Zheng, Hai-xia / 郑海霞, Yang, Liu-qing / 杨柳清, Chen, Ling / 陈 玲, and Guo, Fang / 郭 芳
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- 2011
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6. Glucose endothelial cytotoxicity and protection by Dan Gua-Fang, a Chinese herb prescription in huVEC in hyperglycemia medium
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Yang Liu-qing, He Wei-dong, Heng Xian-pei, Guo Fang, Chen Xu-zheng, Chu Ke-dan, Hong Zheng-feng, Zheng Hai-xia, Chen Ke-ji, Chen Wen-lie, Chen Ling, and Lin Mao-long
- Subjects
medicine.medical_specialty ,food.ingredient ,Endothelium ,Arteriosclerosis ,Cell Survival ,Endocrinology, Diabetes and Metabolism ,Dan gua-fang ,Statistics, Nonparametric ,Cell Line ,Diabetes Complications ,chemistry.chemical_compound ,Endocrinology ,food ,Diabetes mellitus ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Diabetic Vascular Complications ,Cytotoxicity ,Traditional medicine ,Dose-Response Relationship, Drug ,business.industry ,Endothelial Cells ,medicine.disease ,Culture Media ,Dose–response relationship ,medicine.anatomical_structure ,Glucose ,L-Glucose ,chemistry ,Herb ,Hyperglycemia ,Regression Analysis ,Endothelium, Vascular ,business ,Drugs, Chinese Herbal - Abstract
Background Low success rate of blood glucose in diabetes is an international problem. The endothelia cytotoxicity of hyperglycemia has been widely accepted. However, it has not been seen in reports of the value of concentration of high glucose beginning to produce cytotoxicity and the relationship between hyperglycemia and cytotoxicity as well as how to effectively prevent and control hyperglycemia cytotoxicity. Dan Gua prescription is an effective Chinese herb prescription for diabetic vascular complications. Methods Dan Gua prescription was contained in Dan Gua liquor utilized in experiments. (1) The cytotoxicity experiment of Dan Gua was carried out with M199 medium whose glucose (Glu) was 5.55 mmol/l to seek for a suitable experimental concentration of Dan Gua. (2) The human vessel endotheliocyte was cultivated for 72 h with mediums containing glucose in different concentrations (Group G1 to Group G11, Glu: 5.5 to 99.9 mmol/l, respectively), and assayed an optical density (OD) value using the 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide method. (3) Experiment 2 was repeated. However, the medium of each group (Groups Y1 to Y11) contained Dan Gua liquor whose concentration was 1/300. Results There was a negative correlation between means of cell OD values and glucose concentrations ( r =−.927, R 2 =.844), and it presented a notable linear correlation ( y =0.681−0.002 x ). Based on the OD value of 5.5-mmol/l glucose concentration (group G1), when glucose concentration reached 22.2 mmol/l (G4), the difference in OD values has a statistical significance. OD values in Y1–Y11 were not less than that of G1. Conclusion There is a notable linear correlation between the endothelial cytotoxicities of Glu and its concentrations. The spinodal point concentration of statistical significance of hyperglycemia cytotoxicity is 22.2 mmol/l; 1/300 Dan Gua can reverse the endothelia cytotoxicity in different concentrations of hyperglycemia.
- Published
- 2008
7. Toxicity features of high glucose on endothelial cell cycle and protection by Dan Gua-Fang (丹瓜方) in ECV-304 in high glucose medium
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Heng, Xian-pei, primary, Chen, Ke-ji, additional, Hong, Zhen-feng, additional, He, Wei-dong, additional, Chu, Ke-dan, additional, Lin, Jiu-mao, additional, Zheng, Hai-xia, additional, Yang, Liu-qing, additional, Huang, Su-ping, additional, Lan, Yuan-long, additional, Chen, Ling, additional, and Guo, Fang, additional
- Published
- 2012
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8. Studies on ciliotoxicity of nasal thermosensible gels of Chinese medicine
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Chu, Ke-Dan, primary
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- 2012
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9. Qualitative and quantitative analysis of major constituents of Paeoniae Radix Alba and Paeoniae Radix Rubra by HPLC-DAD-Q-TOF-MS/MS.
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LIU Jie, CHEN Lin, FAN Cai-rong, LI Huang, HUANG Ming-qing, XIANG Qing, XU Wen, XU Wei, CHU Ke-dan, and LIN Yu
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- 2015
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10. Research on volatile components of Gualou Guizhi decoction and its components in rat brain by GC-MS.
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LI Huang, XU Wen, XU Wei, ZHANG Yu-qin, CHU Ke-dan, CHEN Li-dian, and CHEN Xian-wen
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- 2014
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11. Anticolchicine cytotoxicity enhanced by Dan Gua-Fang, a Chinese herb prescription in ECV304 in mediums.
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Heng, Xian-Pei, Chen, Ke-Ji, Hong, Zhen-Feng, He, Wei-Dong, Chu, Ke-Dan, Chen, Wen-Lie, Zheng, Hai-Xia, Yang, Liu-Qing, Chen, Ling, and Guo, Fang
- Abstract
OBJECTIVE: To study the effect of anticolchicine cytotoxicity of Dan Gua-Fang (), a Chinesea Chinese), a Chinese herbal compound prescription on endothelial cells of vein (ECV304) cultivated in mediums of different glucose concentrations as well as the proliferation of those cells in the same conditions, in order to reveal the value of Dan Gua-Fang in preventing and treating endothelial damage caused by hyperglycemia in diabetes mellitus. METHODS: The research was designed as three stages. The growing state and morphological changes were observed when ECV304 were cultivated in the culture mediums, which have different glucose concentrations with or without Dan Gua-Fang and at the same time with or without colchicine. RESULTS: (1) Dan Gua-Fang at all concentrations reduced the floating cell population of ECV304 cultivated in hyperglycemia mediums. (2) Dan Gua-Fang at all concentrations and hyperglycemia both had a function of promoting 'pseudopod-like' structure formation in cultivated ECV304, but the function was not superimposed in mediums containing both hyperglycemia and Dan Gua-Fang. (3) Colchicine reduced and even vanished the 'pseudopod-like' structure of the endotheliocyte apparently cultivated in mediums of hyperglycemia or with Dan Gua-Fang. The 'pseudopod-like' structure of the endotheliocyte emerged quickly in Dan Gua-Fang groups after colchicine was removed, but it was not the case in hyperglycemia only without Dan Gua-Fang groups. (4) Dan Gua-Fang reduced the mortality of cells cultivated in mediums containing colchicine. The cell revived to its normal state fast after colchicine was removed. CONCLUSION: Dan Gua-Fang has the functions of promoting the formation of cytoskeleton and fighting against colchicine cytotoxicity. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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12. Perspectives of herbs and their natural compounds, and herb formulas on treating diverse diseases through regulating complicated JAK/STAT signaling.
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Chen JY, Xiao-Yun Tian, Wei SS, Yang YJ, Deng S, Jiao CJ, Wang CJ, Chu KD, Ma XQ, and Xu W
- Abstract
JAK/STAT signaling pathways are closely associated with multiple biological processes involved in cell proliferation, apoptosis, inflammation, differentiation, immune response, and epigenetics. Abnormal activation of the STAT pathway can contribute to disease progressions under various conditions. Moreover, tofacitinib and baricitinib as the JAK/STAT inhibitors have been recently approved by the FDA for rheumatology disease treatment. Therefore, influences on the STAT signaling pathway have potential and perspective approaches for diverse diseases. Chinese herbs in traditional Chinese medicine (TCM), which are widespread throughout China, are the gold resources of China and have been extensively used for treating multiple diseases for thousands of years. However, Chinese herbs and herb formulas are characterized by complicated components, resulting in various targets and pathways in treating diseases, which limits their approval and applications. With the development of chemistry and pharmacology, active ingredients of TCM and herbs and underlying mechanisms have been further identified and confirmed by pharmacists and chemists, which improved, to some extent, awkward limitations, approval, and applications regarding TCM and herbs. In this review, we summarized various herbs, herb formulas, natural compounds, and phytochemicals isolated from herbs that have the potential for regulating multiple biological processes via modulation of the JAK/STAT signaling pathway based on the published work. Our study will provide support for revealing TCM, their active compounds that treat diseases, and the underlying mechanism, further improving the rapid spread of TCM to the world., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Chen, Xiao-Yun Tian, Wei, Yang, Deng, Jiao, Wang, Chu, Ma and Xu.)
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- 2022
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13. [Preparation of Rhus chinensis total phenolic acid pellets by extrusion-spheronisation method].
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Lu XY, Xu W, Ye M, Chu KD, Xu W, Wang XY, and Zheng HY
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- Particle Size, Solubility, Drug Compounding methods, Hydroxybenzoates chemistry, Rhus chemistry
- Abstract
Extrusion-spheronisation method was used to prepare Rhus chinensis total phenolic acid pellets. The formula and preparation of R. chinensis total phenolic acid pellets were optimized. The formulas( drug loading capacity,diluent,wetting agent and anti-sticking agent) were determined by the single factor test with yield,appearance and performance as the indexes. The preparation was optimized by Box-Behnken design and response surface method,with the rate of extrusion,rate of spheronization and time of spheronization as the independent variables and the overall desirability value of yield,friability and roundness as the dependent variables. The optimal formula of pellets was as follows: drug loading capacity 28. 7%,MCC-lactose 9 ∶1,silicon dioxide as anti-sticking agent,and 60% ethanol as wetting agent. The optimal preparation was determined as follows: the rate of extrusion was 43 r·min-1,the rate of spheronization was 1 800 r·min-1,and the time of spheronization was 4 min. The absolute deviation between predicted value and estimated value under the conditions was less than 5. 0%,with a high degree of model fit. The preparation parameters obtained were accurate,reliable and reproducible. Under scanning electron microscopy( SEM),R. chinensis total phenolic acid pellets were uniform in diameter,round and smooth. The optimal formulation and process are stable and feasible for preparing R. chinensis total phenolic acid pellets.
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- 2019
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14. [Determination of seven ingredients of different grades Alismatis Rhizoma by QAMS method].
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Tai YN, Weng YH, Zhang SP, Xu W, Li XY, Lin QQ, Chu KD, and Wu SS
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- Alismatales chemistry, Drugs, Chinese Herbal analysis, Phytochemicals analysis, Rhizome chemistry
- Abstract
The present study is to establish a quantitative analysis of multi-components by single marker(QAMS) for determining contents of seven compositions in Alismatis Rhizoma, alismoxide, alisol C 23-acetate, alisol A, alismol, alisol B, alisol B 23-acetate and 11-deoxy-alisol B. Six relative correction factors(RCFs) of alismoxide, alisol C 23-acetate, alisol A, alismol, alisol B and 11-deoxy-alisol B were established in the UPLC method with alisol B 23-acetate as the internal standard, which was to calculate the mass fraction of each. The mass fraction of seven effective constituents in Alismatis Rhizoma was calculated by the external standard method(ESM) at the same time. Compared with the content results determined by the ESM and QAMS, the feasibility and accuracy of QAMS method were verified. Within the linear range, the RCFs of alismoxide, alisol C 23-acetate, alisol A, alismol, alisol B, 11-deoxy-alisol B were 0.946, 4.183, 0.915, 1.039, 0.923 and 1.244, respectively, with good repeatability in different experimental conditions. There was no significant difference between the QAMS method and ESM method. Then, QAMS method was applied to determination of the different degree Alismatis Rhizoma from different areas. As a result, the concentrations of 7 components have differences in different areas, but no significant differences in different grades. The QAMS method is feasible and accurate for the determination of the seven chemical compositions, and which can be used for quality control of Alismatis Rhizoma.
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- 2019
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15. [Quality evaluation of Gualou Guizhi decoction based on chemical compositions and biological effects].
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Li H, Qiao LF, Zhang YQ, Xu W, Xu W, Chu KD, and Lin Y
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- Animals, Chromatography, High Pressure Liquid, Drugs, Chinese Herbal pharmacology, Neurons drug effects, Zebrafish, Drugs, Chinese Herbal standards, Quality Control
- Abstract
The paper was aimed to establish a quality evaluation model for Gualou Guizhi decoction based on the chemical compositions and biological effects. Ultra high performance liquid chromatograph-mass spectrometer was used to analyze and determine 24 kinds of chemical compositions in Gualou Guizhi decoction, and then, biological activity effect was quantitatively assessed in a zebrafish neuronal injury model which was induced by mycophenolate mofetil (MMF). As a result, the established method for quality evaluation of Gualou Guizhi decoction based on the chemical compositions and biological effects is feasible, stable and reliable, which can provide reference for quality control of compound Chinese medicines., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose., (Copyright© by the Chinese Pharmaceutical Association.)
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- 2017
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16. Effects of Xingbi gel on leukotriene E4 and immunoglobulin E production and nasal eosinophilia in a guinea pig model for allergic rhinitis.
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Ai S, Zheng J, Chu KD, and Zhang HS
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- Administration, Intranasal, Animals, Anti-Allergic Agents administration & dosage, Biomarkers blood, Budesonide pharmacology, Disease Models, Animal, Drugs, Chinese Herbal administration & dosage, Eosinophilia blood, Eosinophilia immunology, Gels, Guinea Pigs, Immunoglobulin E immunology, Leukotriene E4 immunology, Male, Nasal Mucosa immunology, Nasal Mucosa metabolism, Rhinitis, Allergic blood, Rhinitis, Allergic immunology, Anti-Allergic Agents pharmacology, Drugs, Chinese Herbal pharmacology, Eosinophilia drug therapy, Immunoglobulin E blood, Leukotriene E4 blood, Nasal Mucosa drug effects, Rhinitis, Allergic drug therapy
- Abstract
Background: Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal airways.Many therapies do not have immediate effects,even which have side-effects.However,the effects of Xingbi gel for the treatment of AR was investigated., Objective: We investigated the effects of Xingbi gel on serum levels of leukotriene E4 (LTE4) and immunoglobulin E (IgE), as well as eosinophil counts in the nasal mucosa using a guinea pig model of allergic rhinitis (AR)., Methods: In addition to a healthy control group without AR, guinea pigs with AR were randomly divided into untreated AR control group, low-dose Xingbi gel (0.2483 g/mL) group, high-dose Xingbi gel (0.4966 g/mL) group, and budesonide group., Results: Compared to the healthy controls, untreated AR guinea pigs had significantly higher ethology scores, serum LTE4 and IgE levels, and nasal mucosa eosinophil counts (p <0.01). Treatments with low-dose Xingbi gel, high-dose Xingbi gel, and budesonide significantly reduced the ethology scores, serum LTE4 and IgE levels, and nasal mucosa eosinophil counts as compared to untreated AR model guinea pigs (p <0.01)., Conclusion: Xingbi gel alleviates AR in part through inhibiting LTE4 and IgE production and reducing eosinophilia in the nasal mucosa.
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- 2015
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17. [Qualitative and quantitative analysis of major constituents of Paeoniae Radix Alba and Paeoniae Radix Rubra by HPLC-DAD-Q-TOF-MS/MS].
- Author
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Liu J, Chen L, Fan CR, Li H, Huang MQ, Xiang Q, Xu W, Xu W, Chu KD, and Lin Y
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- Bridged-Ring Compounds chemistry, Glucosides chemistry, Molecular Structure, Monoterpenes chemistry, Paeonia classification, Chromatography, High Pressure Liquid methods, Drugs, Chinese Herbal chemistry, Paeonia chemistry, Tandem Mass Spectrometry methods
- Abstract
In order to explore the differences of chemical constituents of Paeoniae Radix Alba and Paeoniae Radix Rubra, a qualitative analytical method of liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (HPLC-Q-TOF-MS/MS) was developed for identification of multi-constituents and an HPLC-DAD analytical method was developed for simultaneously determining 14 major compounds (gallic acid, protocatechuic acid, paeoniflorin sulfonate, protocatechuic aldehyde, methyl gallate, oxypaeoniflorin, catechin, albiflorin, and paeoniflorin, ethyl gallate, benzoic acid, pentagaloylglucose, benzoyl-paeoniflorin, and paeonol) in Paeoniae Radix Alba and Paeoniae Radix Rubra. Q-TOF/MS qualitative analysis was performed under negative ion mode and inferred 38 components of Paeoniae Radix Alba and 30 components of Paeoniae Radix Rubra. HPLC-DAD quantitative method result showed the contents of 8 ingredients were different between Paeoniae Radix Alba and Paeoniae Radix Rubra. The results indicated that the new approach was applicable in qualitative and quantitative quality control of Paeoniae Radix Alba and Paeoniae Radix Rubra.
- Published
- 2015
18. [Research on volatile components of gualou guizhi decoction and its components in rat brain by GC-MS].
- Author
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Li H, Xu W, Xu W, Zhang YQ, Chu KD, Chen LD, and Chen XW
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- Animals, Gas Chromatography-Mass Spectrometry, Male, Rats, Rats, Sprague-Dawley, Brain drug effects, Drugs, Chinese Herbal chemistry, Drugs, Chinese Herbal pharmacology, Volatile Organic Compounds chemistry, Volatile Organic Compounds pharmacology
- Abstract
To investigate the role of volatile components in the compound and to find the substance foundation of Gualou Guizhi decoction (GLGZD) for curing extremities spasticity after stroke. The chemical compositions of essential oil, obtained by hydrodistillation from Gualou Guizhi decoction and its major constituting herbs (Trichosanthis Radix, Paeoniae Alba Radix, Cinnamomi Ramulus, Zingiberis Recens Rhizoma, Glycyrrhizae Radix, Ziziphi Jujubae Fructus) were analyzed by GC-MS to evaluate the correlativity between volatile components of GLGZD and its major constituting herbs, and volatile components after oral administration of GLGZD in the rats' brain. Volatile components of GLGZD are mainly derived from Cinnamomi Ramulus, Zingiberis Recens Rhizoma, Ziziphi Jujubae Fructus, Trichosanthis Radix. The volatile components in the brain is mostly derived from radix trichosanthis. Compared with individual herbs of GLGZD, the dissolution of the components increase or new components appear after compatibility of six herbs. Adminstrated with GLGZD, the results point out that volatile components in the brain play a neuroprotective role through passing the brain.
- Published
- 2014
19. [Preparation of self-microemulsion drug delivery system of the mixture of paeonol and borneol based on Xingbi Fang].
- Author
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Lü FQ, Li H, Xu W, Zhang X, Huang MQ, Zheng J, and Chu KD
- Subjects
- Acetophenones toxicity, Administration, Intranasal, Animals, Bufonidae, Camphanes toxicity, Cilia drug effects, Drug Combinations, Drugs, Chinese Herbal toxicity, Emulsions, Ethylene Glycols chemistry, Female, Male, Nasal Mucosa drug effects, Oleic Acids chemistry, Particle Size, Polyethylene Glycols chemistry, Solubility, Surface-Active Agents chemistry, Acetophenones administration & dosage, Camphanes administration & dosage, Drug Delivery Systems methods, Drugs, Chinese Herbal administration & dosage
- Abstract
The aim of this study is to prepare self-microemulsifying drug delivery system (SMEDDS) of the mixture of paeonol (Pae) and borneol (Bor). Solubility test, ternary phase diagrams and simplex lattice method were employed to screen and optimize the formulation of the mixture of Pae and Bor-loaded SMEDDS. After formed into microemulsions, the particle diameter (PD) was determined and a TEM was employed to observe the microemulsions' morphology. The contents of Pae and Bor were determined by gas chromatography. As a result, while ethyl oleate (EO) as the oil phase, cremophor EL35 (EL35) as surfactant and Transcutol HP (HP) as cosurfactant, the range of the microemulsion on the ternary phase diagram was larger than other combinations. And at a ratio of 20:45:35, the microemulsions' PD was about 34 nm and the polydispersity index (PI) was about 0.2. There were 16% of Pae, 2% of Bor, 16% of EO, 37% of EL35 and 29% of HP in the prepared SMEDDS. The preparation process of the Pae and Bor-loaded SMEDDS based on Xingbi Fang is simple and feasible. This study provides a reference for the researches on the related traditional Chinese medicine and the related components.
- Published
- 2013
20. [Effect of aike mixture on fibroplasia and inflammatory infiltration in rats with non-bacterial prostatitis].
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Zhang MJ, Chu KD, and Cheng XL
- Subjects
- Animals, Fibroblasts pathology, Male, Prostatitis pathology, Random Allocation, Rats, Rats, Sprague-Dawley, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Drugs, Chinese Herbal therapeutic use, Fibroblasts drug effects, Phytotherapy, Prostatitis drug therapy
- Abstract
Objective: To assess the anti-inflammatory effect of Aike Mixture (AKM) on rats with nonbacterial prostatitis (NBP)., Methods: Rat model of NBP was established by injection of Xiaozhiling Injection. The experimental rats were randomized into 7 groups: the three AKM groups (A1, A2 and A3), treated with high, middle and low dose of AKM respectively, the 2 positive control groups (C1 and C2), treated by Bazheng Mixture (BZM) and Qianliexian Decoction (QLXD) respectively, the model control group (Cm) and the sham-operative control group (Cso). The pathological changes in rats' prostate were observed by light microscope and transmission electron microscope., Results: Significant differences in the number and structure of acini, mesenchyma, as well as the degrees of anti-fibroplasia and inflammatory cell infiltration were shown between the treated groups (A1, A2, A3, C1, C1, C2) and the untreated groups (Cm, Cso), with statistical significance (P < 0.05 or P < 0.01). However, the anti-fibroplasia and anti-inflammatory effects in A1 were better than that in the two positive control groups significantly (P < 0.05 or P < 0.01)., Conclusions: AKM is a new TCM drug functioned for dispersing Gan-qi in treating NBP. It shows a better efficacy than that of BZM and QLXD, the two Chinese herbal medicines for clearing heat with remove dampness and activating blood circulation to remove stasis, respectively. Aike Mixture; prostatitis; pathological observation
- Published
- 2009
21. [Clinical study on treatment of chronic prostatitis/chronic pelvic pain syndrome by three different TCM principles].
- Author
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Zhang MJ, Chu KD, and Shi YL
- Subjects
- Adult, Chronic Disease, Diagnosis, Differential, Double-Blind Method, Humans, Male, Middle Aged, Pelvic Pain diagnosis, Pelvic Pain etiology, Prostatitis complications, Prostatitis diagnosis, Syndrome, Treatment Outcome, Drugs, Chinese Herbal therapeutic use, Medicine, Chinese Traditional methods, Pelvic Pain drug therapy, Phytotherapy, Prostatitis drug therapy
- Abstract
Objective: To assess the efficacy of various therapeutic principles of TCM in treating patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)., Methods: Adopting blinded controlled trial method, 218 patients with CP/CPPS were randomly assigned to 4 groups: Group A treated with Aike Decoction for smoothing Gan-qi; Group B with Bazhengsan Decoction for clearing heat and removing dampness; Group C with Qianliexianyan Decoction for promoting blood circulation to remove stasis; and Group D with placebo. The scores of NIH chronic prostatitis symptom index (NIH-CPSI), clinical symptoms, including pain, symptoms of urinary tract and quality of life (QOL), and TCM syndrome integral were estimated at the beginning, the end of the 2nd and 4th week in the study., Results: Compared with the others, Group A showed a superiority in improving NIH-CPSI, scores of various clinical symptoms and TCM syndrome integral at the 2nd week, and improving NIH-CPSI, scores of pain and QOL at the 4th week (all P < 0.05), while the improvement on urinary tract symptoms and TCM syndrome integral in Group A at the 4th week were better than those in Group B and D, but insignificantly different to those in Group C, respectively. No adverse reaction occurred in Group A and D, but it did occur in the other two groups., Conclusion: TCM therapy for smoothing Gan-qi shows good efficacy with quick initiating and high safety, it is an important principle for the treatment of CP/CPPS.
- Published
- 2007
22. [Aike mixture has good anti-inflammatory and analgesic effects on mice].
- Author
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Zhang MJ, Chu KD, Cheng XL, Pan XD, Cheng WJ, Yu KY, Tan YH, Liu JZ, Shi YL, Zheng S, and Liu QB
- Subjects
- Animals, Chronic Disease, Disease Models, Animal, Drug Combinations, Male, Mice, Mice, Inbred ICR, Oleanolic Acid pharmacology, Oleanolic Acid therapeutic use, Saponins therapeutic use, Oleanolic Acid analogs & derivatives, Phytotherapy, Prostatitis drug therapy, Saponins pharmacology
- Abstract
Objective: To study the anti-inflammatory and analgesic actions of Aike Mixture (AKM)., Methods: A total of 100 male mice were randomly assigned into 5 groups: a normal control group, a drug control group (a hydrocortisone subgroup and an atropine subgroup), a high-dose AKM group, a mid-dose AKM group and a low-dose AKM group. Xylene was spread on the left ear of the experimental mice to induce inflammation, and 1% acetic acid solution injected into the abdominal cavity to produce pain so as to cause the body bend. Different doses of AKM were given and their actions observed., Results: AKM had obvious anti-inflammatory effect on the xylene-induced ear tumefaction and inhibited the pain-caused body bend in the AKM groups, with significant difference from the normal control (P < 0.01)., Conclusion: AKM has good anti-inflammatory and analgesic effects, which is of clinical significance in the treatment of chronic prostatitis.
- Published
- 2007
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