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Endocrine mucin-producing sweat gland carcinoma (EMPSGC) and primary cutaneous mucinous carcinoma (PCMC) are both uncommon low-grade cutaneous adnexal tumors with predilection for the eyelids of elderly women. Their clinical appearance is nonspecific, typically presenting as a slowly growing poorly circumscribed papule, nodule, plaque, or swelling. Histological features of EMPSGC include a lobulated dermal neoplasm with bland cytology and an invasive mucinous component in up to half of the cases. PCMC exhibits tumor nests suspended in abundant pools of mucin with focal strands or nests of tumor cells infiltrating the dermis. Because of their rarity and banal cytological features, both entities pose a risk for misdiagnosis with other benign/malignant cutaneous adnexal neoplasms. Histomorphological features can suggest a diagnosis of EMPSGC or PCMC, but immunohistochemistry is necessary for confirmation. A review of the literature showed variable results of antigens present in EMPSGC, and many of the positive markers only show sparse or focal immunoreactivity of tumor cells. As a result, diffusely positive markers play a crucial role in identification of these tumors, particularly with initial superficial biopsies. We present 9 cases of EMPSGC and 5 cases of PCMC with strong and diffuse immunoreactivity to renal cell carcinoma antigen. This novel finding can be useful in the diagnosis of EMPSGC and PCMC in combination with other known positive markers to differentiate them from other cutaneous neoplasms. In addition, it provides further evidence that EMPSGC could be a precursor lesion to PCMC with both existing on a spectrum.

International audience; In Ref. (GAMBIT Collaboration: Athron et. al., Eur. Phys. J. C. arXiv:1705.07908, 2017) we introduced the global-fitting framework GAMBIT. In this addendum, we describe a new minor version increment of this package. GAMBIT 1.1 includes full support for Mathematica backends, which we describe in some detail here. As an example, we backend SUSYHD (Vega and Villadoro, JHEP 07:159, 2015), which calculates the mass of the Higgs boson in the MSSM from effective field theory. We also describe updated likelihoods in PrecisionBit and DarkBit, and updated decay data included in DecayBit.

The European physical journal / C 77(12), 831 (2017). doi:10.1140/epjc/s10052-017-5155-4, We introduce DarkBit, an advanced software code for computing dark matter constraints on various extensions to the Standard Model of particle physics, comprising both new native code and interfaces to external packages.This release includes a dedicated signal yield calculator for gamma-ray observations, which significantly extends current tools by implementing a cascade decay Monte Carlo, as well as a dedicated likelihood calculator for current and future experiments (gamLike). This provides a general solution for studying complex particle physics models that predict dark matter annihilation to a multitude of final states. We also supply a direct detection package that models a large range of direct detection experiments (DDCalc), and provides the corresponding likelihoods for arbitrary combinations of spin-independent and spin-dependent scattering processes. Finally, we provide custom relic density routines along with interfaces to DarkSUSY, micrOMEGAs,and the neutrino telescope likelihood package nulike. DarkBit is written in the framework of the Global And Modular Beyond the Standard Model Inference Tool (GAMBIT), providing seamless integration into a comprehensive statistical fitting framework that allows users to explore new models with both particle and astrophysics constraints, and a consistent treatment of systematic uncertainties. In this paper we describe its main functionality, provide a guide to getting started quickly, and show illustrative examples for resultsobtained with DarkBit (both as a standalone tool and as a GAMBIT module). This includes a quantitative comparison between two of the main dark matter codes (DarkSUSY and micrOMEGAs), and application ofDarkBit’s advanced direct and indirect detection routines to a simple effective dark matter model., Published by Springer, Berlin

If dark matter is composed of weakly interacting particles, Earth's orbital motion may induce a small annual variation in the rate at which these particles interact in a terrestrial detector. The DAMA collaboration has identified at a 9.3$\sigma$ confidence level such an annual modulation in their event rate over two detector iterations, DAMA/NaI and DAMA/LIBRA, each with $\sim7$ years of observations. We statistically examine the time dependence of the modulation amplitudes, which "by eye" appear to be decreasing with time in certain energy ranges. We perform a chi-squared goodness of fit test of the average modulation amplitudes measured\ by the two detector iterations which rejects the hypothesis of a consistent modulation amplitude at greater than 80\%, 96\%, and 99.6\% for the 2--4~keVee, 2--5~keVee and 2--6~keVee energy ranges, respectively. We also find that among the 14 annual cycles there are three $\gtrsim 3\sigma$ departures from the average in the 5-6~keVee energy range. In addition, we examined several phenomenological models for the time dependence of the modulation amplitude. Using a maximum likelihood test, we find that descriptions of the modulation amplitude as decreasing with time are preferred over a constant modulation amplitude at anywhere between 1$\sigma$ and 3$\sigma$, depending on the phenomenological model for the time dependence and the signal energy range considered. A time dependent modulation amplitude is not expected for a dark matter signal, at least for dark matter halo morphologies consistent with the DAMA signal. New data from DAMA/LIBRA--phase2 will certainly aid in determining whether any apparent time dependence is a real effect or a statistical fluctuation., Comment: 13 pages, 1 figure

Despite the fact that society and organizations rely heavily on Information Systems (IS) and software, the maintenance of vendor-supplied IS, in particular standard package software has gained little attention within the academic literature. This paper presents a conceptual study of the current state of research concerning the reasons for deferral and performance of vendor-supplied maintenance by the purchasing organization. These reasons have so far neither been investigated together nor from that perspective. Based on a systematic literature review and taking the purchaser’s viewpoint, reasons for maintenance deferral and performance are identified from the literature. They build the groundwork and foundation for a Maintenance Lifecycle Model that provides a starting point to research vendor-supplied maintenance from the customer’s point of view.

We combine and extend the analyses of effective scalar, vector, Majorana and Dirac fermion Higgs portal models of dark matter (DM), in which DM couples to the Standard Model (SM) Higgs boson via an operator of the form $\mathcal{O}_{\textrm{DM}}\, H^\dagger H$. For the fermion models, we take an admixture of scalar $\overline{\psi} \psi$ and pseudoscalar $\overline{\psi} i\gamma_5 \psi$ interaction terms. For each model, we apply constraints on the parameter space based on the Planck measured DM relic density and the LHC limits on the Higgs invisible branching ratio. For the first time, we perform a consistent study of the indirect detection prospects for these models based on the WMAP7/Planck observations of the cosmic microwave background, a combined analysis of 15 dwarf spheroidal galaxies by Fermi-LAT and the upcoming Cherenkov Telescope Array (CTA). We also perform a correct treatment of the momentum-dependent direct search cross section that arises from the pseudoscalar interaction term in the fermionic DM theories. We find, in line with previous studies, that current and future direct search experiments such as LUX and XENON1T can exclude much of the parameter space, and we demonstrate that a joint observation in both indirect and direct searches is possible for high mass weakly interacting massive particles. In the case of a pure pseudoscalar interaction of a fermionic DM candidate, future gamma-ray searches are the only class of experiment capable of probing the high mass range of the theory., Comment: 53 pages, 16 figures, REVTeX-4.1 processed with BibTeX and pdfLaTeX. v2: added references; submitted to Phys. Rev. D. v3: added references and corrected few typos; matches the version accepted for publication in Phys. Rev. D. v4: matches the version published in Phys. Rev. D

Dark matter searches in gamma ray final states often make use of the fact that photons can be produced from final state muons. Modern Monte Carlo generators and DM codes include the effects of final state radiation from muons produced in the dark matter annihilation process itself, but neglect the O(1%) radiative correction that arises from the subsequent muon decay. After implementing this correction we demonstrate the effect that it can have on dark matter phenomenology by considering the case of dark matter annihilation to four muons via scalar mediator production. We first show that the AMS-02 positron excess can no longer easily be made consistent with this final state once the Fermi-LAT dwarf limits are calculated with the inclusion of radiative muon decays, and we next show that the Fermi-LAT galactic centre gamma excess can be improved with this final state after inclusion of the same effect. We provide code and tables for the implementation of this effect in the popular dark matter code micrOMEGAs, providing a solution for any model producing final state muons., 11 pages, 7 figures + anc files

The spatial and velocity distributions of dark matter particles in the Milky Way Halo affect the signals expected to be observed in searches for dark matter. Results from direct detection experiments are often analyzed assuming a simple isothermal distribution of dark matter, the Standard Halo Model (SHM). Yet there has been skepticism regarding the validity of this simple model due to the complicated gravitational collapse and merger history of actual galaxies. In this paper we compare the SHM to the results of cosmological hydrodynamical simulations of galaxy formation to investigate whether or not the SHM is a good representation of the true WIMP distribution in the analysis of direct detection data. We examine two Milky Way-like galaxies from the MaGICC cosmological simulations (a) with dark matter only and (b) with baryonic physics included. The inclusion of baryons drives the shape of the DM halo to become more spherical and makes the velocity distribution of dark matter particles less anisotropic especially at large heliocentric velocities, thereby making the SHM a better fit. We also note that we do not find a significant disk-like rotating dark matter component in either of the two galaxy halos with baryons that we examine, suggesting that dark disks are not a generic prediction of cosmological hydrodynamical simulations. We conclude that in the Solar neighborhood, the SHM is in fact a good approximation to the true dark matter distribution in these cosmological simulations (with baryons) which are reasonable representations of the Milky Way, and hence can also be used for the purpose of dark matter direct detection calculations., Minor changes to match JCAP version. 21 pages, 9 figures

Inflationary cosmology, a period of accelerated expansion in the early Universe, is being tested by cosmic microwave-background measurements. Generic predictions of inflation have been shown to be correct, and in addition individual models are being tested. The model of natural inflation is examined in light of recent three-year data from the Wilkinson Microwave Anisotropy Probe and shown to provide a good fit. The inflaton potential is naturally flat due to shift symmetries, and in the simplest version is V(ϕ) = Λ4 [1 ± cos (Nϕ/f)]. The model agrees with WMAP3 measurements as long as f > 0.7 m Pl (where m Pl = 1.22 × 1019 GeV ) and Λ ~ m GUT . The running of the scalar spectral index is shown to be small — an order of magnitude below the sensitivity of WMAP3. The location of the field in the potential when perturbations on observable scales are produced is examined; for f > 5 m Pl , the relevant part of the potential is indistinguishable from a quadratic, yet has the advantage that the required flatness is well motivated. Depending on the value of f, the model falls into the large field (f ≥ 1.5 m Pl ) or small field (f < 1.5 m Pl ) classification scheme that has been applied to inflation models. Natural inflation provides a good fit to WMAP3 data.

We test the plausibility that a Majorana fermion dark matter candidate with a scalar mediator explains the gamma ray excess from the Galactic center. Assuming that the mediator couples to all third generation fermions we calculate observables for dark matter abundance and scattering on nuclei, gamma, positron, and anti-proton cosmic ray fluxes, radio emission from dark matter annihilation, and the effect of dark matter annihilations on the CMB. After discarding the controversial radio observation the rest of the data prefers a dark matter (mediator) mass in the 10-100 (3-1000) GeV region and weakly correlated couplings to bottom quarks and tau leptons with values of 10^{-3}-1 at the 68\% credibility level., 23 pages, 6 figures, 2 tables. arXiv admin note: text overlap with arXiv:1407.0174

We present LUXCalc, a new utility for calculating likelihoods and deriving WIMP-nucleon coupling limits from the recent results of the LUX direct search dark matter experiment. After a brief review of WIMP-nucleon scattering, we derive LUX limits on the spin-dependent WIMP-nucleon couplings over a broad range of WIMP masses, under standard assumptions on the relevant astrophysical parameters. We find that, under these and other common assumptions, LUX excludes the entire spin-dependent parameter space consistent with a dark matter interpretation of DAMA's anomalous signal, the first time a single experiment has been able to do so. We also revisit the case of spin-independent couplings, and demonstrate good agreement between our results and the published LUX results. Finally, we derive constraints on the parameters of an effective dark matter theory in which a spin-1 mediator interacts with a fermionic WIMP and Standard Model fermions via axial-vector couplings. A detailed appendix describes the use of LUXCalc with standard codes to place constraints on generic dark matter theories., Comment: 16 pages, 6 figures. Software package included as ancillary files. v2: added references, Baksan limits. v3: clarifications and small corrections, results unchanged

Weakly Interacting Massive Particles (WIMPs) may constitute a large fraction of the matter in the Universe. There are excess events in the data of DAMA/LIBRA, CoGeNT, CRESST-II, and recently CDMS-Si, which could be consistent with WIMP masses of approximately 10 GeV/c2. However, for MDM > 10 GeV/c2 null results of the CDMS-Ge, XENON, and LUX detectors may be in tension with the potential detections for certain dark matter scenarios and assuming a certain light response. We propose the use of a new class of biological dark matter (DM) detectors to further examine this light dark matter hypothesis, taking advantage of new signatures with low atomic number targets, Two types of biological DM detectors are discussed here: DNA-based detectors and enzymatic reactions (ER) based detectors. In the case of DNA-based detectors, we discuss a new implementation. In the case of ER detectors, there are four crucial phases of the detection process: a) change of state due to energy deposited by a particle; b) amplification due to the release of energy derived from the action of an enzyme on its substrate; c) sustainable but non-explosive enzymatic reaction; d) self-termination due to the denaturation of the enzyme, when the temperature is raised. This paper provides information of how to design as well as optimize these four processes., 29 pages

Direct detection experiments, which are designed to detect the scattering of dark matter off nuclei in detectors, are a critical component in the search for the Universe’s missing matter. This Colloquium begins with a review of the physics of direct detection of dark matter, discussing the roles of both the particle physics and astrophysics in the expected signals. The count rate in these experiments should experience an annual modulation due to the relative motion of the Earth around the Sun. This modulation, not present for most known background sources, is critical for solidifying the origin of a potential signal as dark matter. The focus is on the physics of annual modulation, discussing the practical formulas needed to interpret a modulating signal. The dependence of the modulation spectrum on the particle and astrophysics models for the dark matter is illustrated. For standard assumptions, the count rate has a cosine dependence with time, with a maximum in June and a minimum in December. Well-motivated generalizations of these models, however, can affect both the phase and amplitude of the modulation. Shown is how a measurement of an annually modulating signal could teach us about the presence of substructure in the galactic halo or about the interactions between dark and baryonic matter. Although primarily a theoretical review, the current experimental situation for annual modulation and future experimental directions is briefly discussed.

The DAMA experiment searches for Weakly Interacting Massive Particle (WIMP) dark matter via its expected but rare interactions within the detector, where the interaction rates will modulate throughout the year due to the orbital motion of the Earth. Over the course of more than 10 years of operation, DAMA has indeed detected a strong modulation in the event rate above the detector threshold of 2 keVee. Under standard assumptions regarding the dark matter halo and WIMP interactions, this signal is consistent with that expected of WIMPs of two different approximate masses: ~ 10 GeV and ~ 70 GeV. We examine how a lower threshold, allowed by recent upgrades to the DAMA detector, may shed light on this situation. We find that the lower threshold data should rule out one of the two mass ranges for spin-independent couplings (in the worst case, disfavoring one of the masses by still more than 2.6$\sigma$) and is likely, though not certain, to do the same for spin-dependent couplings. Furthermore, the data may indicate whether the interaction is predominantly spin-independent or spin-dependent in some cases. Our findings illustrate the importance of a low threshold in modulation searches., Comment: 26 pages, 7 figures. v2: expanded discussion, added references

Using polymerase chain reaction DNA amplification, we identified K-ras oncogene mutations in bronchial biopsies obtained from patients undergoing bronchoscopy for clinical indications. We hypothesized that these mutations would be found in a field encompassing malignant and nonmalignant tissues in patients with pulmonary carcinomas, and also possibly in tissue from some patients who smoked but did not have pulmonary malignancy. We found K-ras mutations in endobronchial biopsies from nine of 22 patients (41%) with carcinoma of the lung. In five of these patients, mutations were found in both malignant and nonmalignant specimens. In two instances, mutations were found only in the neoplastic tissue, and in two cases mutations were present only in the nonmalignant tissue. Furthermore, we identified two patients with K-ras mutations among seven patients in whom no clinical malignancy was apparent. Our data suggest that some oncogene activations may occur over a broad area in smokers with and without malignancy, and they imply that K-ras mutations may serve as surrogate markers for malignant potential.

It is shown that a Weakly Interacting Massive dark matter Particle (WIMP) interpretation for the positron excess observed in a variety of experiments, HEAT, PAMELA, and AMS-02, is highly constrained by the Fermi/LAT observations of dwarf galaxies. In particular, this paper has focused on the annihilation channels that best fit the current AMS-02 data (Boudaud et al., 2014). The Fermi satellite has surveyed the $\gamma$-ray sky, and its observations of dwarf satellites are used to place strong bounds on the annihilation of WIMPs into a variety of channels. For the single channel case, we find that dark matter annihilation into {$b\bar{b}$, $e^+e^-$, $\mu^+\mu^-$, $\tau^+\tau^-$, 4-$e$, or 4-$\tau$} is ruled out as an explanation of the AMS positron excess (here $b$ quarks are a proxy for all quarks, gauge and Higgs bosons). In addition, we find that the Fermi/LAT 2$\sigma$ upper limits, assuming the best-fit AMS-02 branching ratios, exclude multichannel combinations into $b\bar{b}$ and leptons. The tension between the results might relax if the branching ratios are allowed to deviate from their best-fit values, though a substantial change would be required. Of all the channels we considered, the only viable channel that survives the Fermi/LAT constraint and produces a good fit to the AMS-02 data is annihilation (via a mediator) to 4-$\mu$, or mainly to 4-$\mu$ in the case of multichannel combinations., Comment: 9 pages, 3 figures. v2: removed spurious space in title. v3,v4: added references

We investigate the interactions of Weakly Interacting Massive Particles (WIMPs) with nuclei in the human body. We are motivated by the fact that WIMPs are excellent candidates for the dark matter in the Universe. Our estimates use a 70 kg human and a variety of WIMP masses and cross-sections. The contributions from individual elements in the body are presented and it is found that the dominant contribution is from scattering off of oxygen (hydrogen) nuclei for the spin-independent (spin-dependent) interactions. For the case of 60 GeV WIMPs, we find that, of the billions of WIMPs passing through a human body per second, roughly ~10 WIMPs hit one of the nuclei in the human body in an average year, if the scattering is at the maximum consistent with current bounds on WIMP interactions. We also study the 10-20 GeV WIMPs with much larger cross-sections that best fit the DAMA, COGENT, and CRESST data sets and find much higher rates: in this case as many as $10^5$ WIMPs hit a nucleus in the human body in an average year, corresponding to almost one a minute. Though WIMP interactions are a source of radiation in the body, the annual exposure is negligible compared to that from other natural sources (including radon and cosmic rays), and the WIMP collisions are harmless to humans., 8 pages. v2: added discussion of radiation exposure due to dark matter

Closed Ecological Systems (CES), i.e. biological systems closed to material but open to energy exchange, have been unexplored as biological tools. Only the investigations of bioregenerative Life Support systems For space missions have created some activity. However, these systems also have enormous potential applications on Earth. The notion of CES came into existence very soon after Ecology became established as a natural science. Indeed, the study of the relationships between different biological specimens in a given location led directly to the understanding that our terrestrial biosphere was the so far unique CES of which we were aware. New and artificial CES can currently be created according to either the holistic or the deterministic approach. It is probable that the final approach will be a combined one, but more knowledge has to be acquired on the exact behaviour of each biological element taken separately and included in the studied CES. Therefore, the big challenge in CES is currently technolog...

We extend our previous studies of the neutrino fluxes expected from neutralino LSP annihilations inside the Sun to include variants of the minimal supersymmetric extension of the Standard Model (MSSM) with squark, slepton and gaugino masses constrained to be universal at the GUT scale, but allowing one or two non-universal supersymmetry-breaking parameters contributing to the Higgs masses (NUHM1,2). As in the constrained MSSM (CMSSM) with universal Higgs masses, there are large regions of the NUHM parameter space where the LSP density inside the Sun is not in equilibrium, so that the annihilation rate may be far below the capture rate, and there are also large regions where the capture rate is not dominated by spin-dependent LSP-proton scattering. The spectra possible in the NUHM are qualitatively similar to those in the CMSSM. We calculate neutrino-induced muon fluxes above a threshold energy of 10 GeV, appropriate for the IceCube/DeepCore detector, for points where the NUHM yields the correct cosmological relic density for representative choices of the NUHM parameters. We find that the IceCube/DeepCore detector can probe regions of the NUHM parameter space in addition to analogues of the focus-point strip and the tip of the coannihilation strip familiar from the CMSSM. These include regions with enhanced Higgsino-gaugino mixing in the LSP composition, that occurs where neutralino mass eigenstates cross over. On the other hand, rapid-annihilation funnel regions in general yield neutrino fluxes that are unobservably small.

We consider the compatibility of DAMA/LIBRA, CoGeNT, XENON10 and XENON100 results for spin-independent (SI) dark matter weakly interacting massive particles, particularly at low masses ($\ensuremath{\sim}10\text{ }\text{ }\mathrm{GeV}$), assuming a standard dark matter halo. The XENON bounds depend on the scintillation efficiency factor ${\mathcal{L}}_{\mathrm{eff}}$ for which there is considerable uncertainty. Thus we consider various extrapolations for ${\mathcal{L}}_{\mathrm{eff}}$ at low energy. With the ${\mathcal{L}}_{\mathrm{eff}}$ measurements we consider, XENON100 results are found to be insensitive to the low-energy extrapolation. We find the strongest bounds are from XENON10, rather than XENON100, due to the lower energy threshold. For reasonable choices of ${\mathcal{L}}_{\mathrm{eff}}$ and for the case of SI elastic scattering, XENON10 is incompatible with the DAMA/LIBRA $3\ensuremath{\sigma}$ region and severely constrains the 7--12 GeV WIMP mass region of interest published by the CoGeNT Collaboration.

We examine the future sensitivity of CoGeNT to the presence of dark matter streams and find that consideration of streams in the data may lead to differences in the interpretation of the results. We show the allowed particle mass and cross section for different halo parameters, assuming spin-independent elastic scattering. As an example, we choose a stream with the same velocity profile as that of the Sagittarius stream (and in the Solar neighborhood) and find that, with an exposure of $\sim$ 10 kg year, the CoGeNT results can be expected to exclude the SHM-only halo in favor of an SHM+stream halo at the 95% (99.7%) confidence level provided the stream contributes 3% (5%) of the local dark matter density. The presence of a significant stream component may result in incorrect estimates of the particle mass and cross section unless the presence of the stream is taken into account. We conclude that the CoGeNT experiment is sensitive to streams and care should be taken to include the possibility of streams when analyzing experimental results., Comment: Main conclusions unchanged. Discussion on CoGeNT annual modulation included. Manuscript expanded and citations added. Accepted in Physical Review D

Weakly interacting massive particles (WIMPs) are amongst the most interesting dark matter (DM) candidates. Many DM candidates naturally arise in theories beyond the standard model (SM) of particle physics, like weak-scale supersymmetry (SUSY). Experiments aim to detect WIMPs by scattering, annihilation or direct production, and thereby determine the underlying theory to which they belong, along with its parameters. Here we examine the prospects for further constraining the Constrained Minimal Supersymmetric Standard Model (CMSSM) with future ton-scale direct detection experiments. We consider ton-scale extrapolations of three current experiments: CDMS, XENON and COUPP, with 1000 kg-years of raw exposure each. We assume energy resolutions, energy ranges and efficiencies similar to the current versions of the experiments, and include backgrounds at target levels. Our analysis is based on full likelihood constructions for the experiments. We also take into account present uncertainties on hadronic matrix elements for neutralino-quark couplings, and on halo model parameters. We generate synthetic data based on four benchmark points and scan over the CMSSM parameter space using nested sampling. We construct both Bayesian posterior PDFs and frequentist profile likelihoods for the model parameters, as well as the mass and various cross-sections of the lightest neutralino. Future ton-scale experiments will help substantially in constraining supersymmetry, especially when results of experiments primarily targeting spin-dependent nuclear scattering are combined with those directed more toward spin-independent interactions., Comment: 53 pages, 19 figures; typos corrected; number of plots reduced and some discussions added in response to referee's comments; matches published version

Models of weak-scale supersymmetry offer viable dark matter (DM) candidates. Their parameter spaces are however rather large and complex, such that pinning down the actual parameter values from experimental data can depend strongly on the employed statistical framework and scanning algorithm. In frequentist parameter estimation, a central requirement for properly constructed confidence intervals is that they cover true parameter values, preferably at exactly the stated confidence level when experiments are repeated infinitely many times. Since most widely-used scanning techniques are optimised for Bayesian statistics, one needs to assess their abilities in providing correct confidence intervals in terms of the statistical coverage. Here we investigate this for the Constrained Minimal Supersymmetric Standard Model (CMSSM) when only constrained by data from direct searches for dark matter. We construct confidence intervals from one-dimensional profile likelihoods and study the coverage by generating several pseudo-experiments for a few benchmark sets of pseudo-true parameters. We use nested sampling to scan the parameter space and evaluate the coverage for the benchmarks when either flat or logarithmic priors are imposed on gaugino and scalar mass parameters. The sampling algorithm has been used in the configuration usually adopted for exploration of the Bayesian posterior. We observe both under- and over-coverage, which in some cases vary quite dramatically when benchmarks or priors are modified. We show how most of the variation can be explained as the impact of explicit priors as well as sampling effects, where the latter are indirectly imposed by physicality conditions. For comparison, we also evaluate the coverage for Bayesian credible intervals, and observe significant under-coverage in those cases., Comment: 30 pages, 5 figures; v2 includes major updates in response to referee's comments; extra scans and tables added, discussion expanded, typos corrected; matches published version

We evaluate the neutrino fluxes to be expected from neutralino LSP annihilations inside the Sun, within the minimal supersymmetric extension of the Standard Model with supersymmetry-breaking scalar and gaugino masses constrained to be universal at the GUT scale (the CMSSM). We find that there are large regions of typical CMSSM $(m_{1/2}, m_0)$ planes where the LSP density inside the Sun is not in equilibrium, so that the annihilation rate may be far below the capture rate. We show that neutrino fluxes are dependent on the solar model at the 20% level, and adopt the AGSS09 model of Serenelli et al. for our detailed studies. We find that there are large regions of the CMSSM $(m_{1/2}, m_0)$ planes where the capture rate is not dominated by spin-dependent LSP-proton scattering, e.g., at large $m_{1/2}$ along the CMSSM coannihilation strip. We calculate neutrino fluxes above various threshold energies for points along the coannihilation/rapid-annihilation and focus-point strips where the CMSSM yields the correct cosmological relic density for tan(beta) = 10 and 55 for $\mu$ > 0, exploring their sensitivities to uncertainties in the spin-dependent and -independent scattering matrix elements. We also present detailed neutrino spectra for four benchmark models that illustrate generic possibilities within the CMSSM. Scanning the cosmologically-favored parts of the parameter space of the CMSSM, we find that the DeepCore detector can pro be some of this parameter space, especially in the focus-point region and possibly also at the low-mass tip of the coannihilation strip. We evaluate the neutrino fluxes to be expected from neutralino LSP annihilations inside the Sun, within the minimal supersymmetric extension of the Standard Model with supersymmetry-breaking scalar and gaugino masses constrained to be universal at the GUT scale (the CMSSM). We find that there are large regions of typical CMSSM $(m_{1/2}, m_0)$ planes where the LSP density inside the Sun is not in equilibrium, so that the annihilation rate may be far below the capture rate. We show that neutrino fluxes are dependent on the solar model at the 20% level, and adopt the AGSS09 model of Serenelli et al. for our detailed studies. We find that there are large regions of the CMSSM $(m_{1/2}, m_0)$ planes where the capture rate is not dominated by spin-dependent LSP-proton scattering, e.g., at large $m_{1/2}$ along the CMSSM coannihilation strip. We calculate neutrino fluxes above various threshold energies for points along the coannihilation/rapid-annihilation and focus-point strips where the CMSSM yields the correct cosmological relic density for tan(beta) = 10 and 55 for $\mu$ > 0, exploring their sensitivities to uncertainties in the spin-dependent and -independent scattering matrix elements. We also present detailed neutrino spectra for four benchmark models that illustrate generic possibilities within the CMSSM. Scanning the cosmologically-favored parts of the parameter space of the CMSSM, we find that the DeepCore detector can probe some of this parameter space, especially in the focus-point region and possibly also at the low-mass tip of the coannihilation strip.

The DAMA/NaI and DAMA/LIBRA annual modulation data, which may be interpreted as a signal for the existence of weakly interacting dark matter (WIMPs) in our galactic halo, are re-examined in light of new measurements of the local velocity relative to the galactic halo. In the vicinity of the Sun, the velocity of the Galactic disk has been estimated to be 250 km/s rather than 220 km/s. Our analysis is performed both with and without the channeling effect included. The best fit regions to the DAMA data are shown to move to slightly lower WIMP masses. Compatibility of DAMA data with null results from other experiments (CDMS, XENON10, and CRESST I) is investigated given these new velocities. A small region of spin-independent (elastic) scattering for 7-8 GeV WIMP masses remains at 3$\sigma$. Spin-dependent scattering off of protons is viable for 5-15 GeV WIMP masses for direct detection experiments (but has been argued by others to be further constrained by Super-Kamiokande due to annihilation in the Sun)., Comment: 18 pages, 6 figures. v2: added reference, minor changes to match JCAP version

We examine the uncertainties in the spin‐independent and ‐dependent elastic scattering cross sections of supersymmetric dark matter particles on protons and neutrons, particularly those that arise due to uncertainties in quark masses and hadronic matrix elements that are related to the π‐nucleon σ term and the spin content of the nucleon. By far the largest single uncertainty is that in spin‐independent scattering induced by our ignorance of the 〈N|qq|N〉 matrix elements linked to the π‐nucleon σ term, which affects the ratio of cross sections on proton and neutron targets as well as their absolute values. This uncertainty is already impacting the interpretations of experimental searches for cold dark matter. We plead for an experimental campaign to determine better the π‐nucleon σ term. Uncertainties in the spin content of the proton affect significantly, but less strongly, the calculation of rates used in indirect searches.

The DAMA/NaI and DAMA/LIBRA annual modulation data, which may be interpreted as a signal for the existence of weakly interacting dark matter (WIMPs) in our galactic halo, are examined in light of null results from other experiments. We use the energy spectrum of the combined DAMA modulation data given in 36 bins, and include the effect of channeling. Several statistical tools are implemented in our study: likelihood ratio with a global fit and with raster scans in the WIMP mass and goodness-of-fit (g.o.f.). These approaches allow us to differentiate between the preferred (global best fit) and allowed (g.o.f.) parameter regions. It is hard to find WIMP masses and couplings consistent with all existing data sets. For spin-independent (SI) interactions, the best fit DAMA regions are ruled out to the 3$\sigma$ C.L., even with channeling taken into account. However, for WIMP masses of ~8 GeV some parameters outside these regions still yield a moderately reasonable fit to the DAMA data and are compatible with all 90% C.L. upper limits from negative searches, when channeling is included. For spin-dependent (SD) interactions with proton-only couplings, a range of masses below 10 GeV is compatible with DAMA and other experiments, with and without channeling, when SuperK indirect detection constraints are included; without the SuperK constraints, masses as high as ~20 GeV are compatible. For SD neutron-only couplings we find no parameters compatible with all the experiments. Mixed SD couplings are examined: e.g. ~8 GeV mass WIMPs with a_n = +/- a_p are found to be consistent with all experiments. In short, there are surviving regions at low mass for both SI and SD interactions; if indirect detection limits are relaxed, some SD proton-only couplings at high masses also survive., Comment: 45 pages, 23 figures. v2: Added references and minor revisions. v3: improvements to some null experiment analyses and DAMA g.o.f. statistical constraints; added DAMA total event rate constraint

We review the uncertainties in the spin-independent and -dependent elastic scattering cross sections of supersymmetric dark matter particles on protons and neutrons. We propagate the uncertainties in quark masses and hadronic matrix elements that are related to the $\pi$-nucleon $\sigma$ term and the spin content of the nucleon. By far the largest single uncertainty is that in spin-independent scattering induced by our ignorance of the $$ matrix elements linked to the $\pi$-nucleon $\sigma$ term, which affects the ratio of cross sections on proton and neutron targets as well as their absolute values. This uncertainty is already impacting the interpretations of experimental searches for cold dark matter. {\it We plead for an experimental campaign to determine better the $\pi$-nucleon $\sigma$ term.} Uncertainties in the spin content of the proton affect significantly, but less strongly, the calculation of rates used in indirect searches., Comment: 25 pages, 10 figures. v2: added references. To appear in PRD

In addition to a smooth component of WIMP dark matter in galaxies, there may be streams of material; the effects of WIMP streams on direct detection experiments is examined in this paper. The contribution to the count rate due to the stream cuts off at some characteristic energy. Near this cutoff energy, the stream contribution to the annual modulation of recoils in the detector is comparable to that of the thermalized halo, even if the stream represents only a small portion (~5% or less) of the local halo density. Consequently the total modulation may be quite different than would be expected for the standard halo model alone: it may not be cosine-like and can peak at a different date than expected. The effects of speed, direction, density, and velocity dispersion of a stream on the modulation are examined. We describe how the observation of a modulation can be used to determine these stream parameters. Alternatively, the presence of a dropoff in the recoil spectrum can be used to determine the WIMP mass if the stream speed is known. The annual modulation of the cutoff energy together with the annual modulation of the overall signal provide a "smoking gun" for WIMP detection., 27 pages, 9 figures. v2: Added reference and minor revisions to match PRD version

The U.S. Navy’s Integrated Condition Assessment System (ICAS) is a shipboard monitoring system that helps enable the Navy’s Condition Based Maintenance (CBM) initiative. ICAS is installed on a large number of Navy Surface Combatants and provides data acquisition, display, and logging, as well as equipment diagnostic analysis for troubleshooting and maintenance tasking of hull mechanical and electrical systems. In recent years, it has been desirable to integrate specialized, third party diagnostic or prognostic software as plug ‘n play modules within the ICAS environment. A specific effort focused on such modules for shipboard LM2500 and Allison 501K gas turbine engines is well underway. Over the course of this three-year Prognostic Enhancement to Diagnostic System (PEDS) program, many lessons have been learned, best practices for ICAS integration have been identified, and the important steps required to field ICAS-capable modules have been realized. This paper summarizes these lessons and processes for future 3rd party integration efforts and provides specific examples for the developed gas turbine modules. The successful deployment of these modules aboard Navy ships is used to validate the ideas presented.Copyright © 2005 by ASME