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Qualitative studies on assisted reproductive technology commonly focus on the perspectives of participants living in major metropolises. In doing so, the experiences of those living outside major cities, and the unique way conditions of spatiality shape access to treatment, are elided. In this paper, we examine how location and regionality in Australia impact upon access and experience of reproductive services. We conducted twelve qualitative interviews with participants residing in regional areas across Australia. We asked participants to discuss their experience with assisted reproduction services and the impacts of location on access, service choice, and experience of care, and analysed the data using reflexive thematic analysis, as outlined by Braun and Clarke (2006, 2019). Participants in this study reported that their location impacted the services available to them, required considerable time in travel, and reduced continuity of care. We draw on these responses to examine the ethical implications of uneven distribution of reproductive services in commercial healthcare settings which rely on market-based mechanisms.

Summary This article examines the emergence of bioethics at Monash University and Australia during the late-1970s and early-1980s. Unlike bioethics in the USA, which was born a decade earlier during policy debates over human experimentation and withdrawal of treatment, bioethics in Australia initially emerged in the university context via interactions among research scientists working at the forefront of reproductive medicine and philosophers seeking to address issues of public concern. These interactions occurred in a rapidly changing university sector that was moving towards research translation and a new global knowledge economy. Drawing on oral histories with philosophers and medical scientists involved in these events, as well as archival materials, this article uses a co-productionist analytic lens to critically examine how changing institutional norms encouraged mutually beneficial interactions between philosophers and scientists, which shaped the emergence of a new and distinctive field of bioethics in Australia.

The challenges to designing and implementing ethically and politically meaningful eating policies are many and complex. This article provides a brief overview of Anne Barnhill and Matteo Bonotti’s Healthy Eating Policy and Political Philosophy: A Public Reason Approach while also critically engaging with the place of racial justice, global interconnectedness, and debates over science in thinking about ethics and politics of public health nutrition and policy. I do not aim to burden Barnhill and Bonotti with the responsibility to fully address these issues, but considering the interconnection of these issues and the ever pressing effects of climate change on local and global food systems, we collectively need to turn to these difficult and pressing questions about what a just food system looks like, what concerns are centred, and who is left out. I group these engagements with Barnhill and Bonotti under three headings: racial liberalism, global food system, and contested nutrition science. I conclude with some remarks about locality.

(1) Background: Albeit the main focus remains largely on mothers, in recent years Developmental Origins of Health and Disease (DOHaD) scientists, including epigeneticists, have started to examine how a father’s environment affects disease risk in children and argued that more attention needs to be given to father’s health-related behaviors for their influence on offspring at preconception (i.e., sperm health) as well as paternal lifestyle influences over the first 1000 days. This research ushers in a new paternal origins of health and disease (POHaD) paradigm and is considered a welcome equalization to the overemphasis on maternal influences. Epigeneticists are excited by the possibilities of the POHaD paradigm but are also cautious about how to interpret data and avoid biased impression of socio-biological reality. (2) Methods: We review sociological and historical literatures on the intersection of gender, food and diet across different social and historical contexts to enrich our understanding of the father; (3) Results: Sociological and historical research on family food practices and diet show that there are no “fathers” in the abstract or vacuum, but they are differently classed, racialized and exist in socially stratified situations where choices may be constrained or unavailable. This confirms that epigeneticists researching POHaD need to be cautious in interpreting paternal and maternal dietary influences on offspring health; (4) Conclusions: We suggest that interdisciplinary approach to this new paradigm, which draws on sociology, history and public health, can help provide the social and historical context for interpreting and critically understanding paternal lifestyles and influences on offspring health.

This review essay critically examines Catherine Mills's Biopolitics (2018) and Camisha Russell's The Assisted Reproduction of Race (2018). Although distinct works, the centrality of race and reproduction provides a point of connection and an opening into reframing contemporary debates within bioethics and biopolitics. In reviewing these books together I hope to show how biopolitical theory and critical philosophy of race can be useful in looking at bioethical problems from a new perspective that open up different kinds of analyses, especially around historically embedded problems like institutional racism and the legacies of colonialism in healthcare.

Since colonisation began in Australia, it has transformed the ecological, social, cultural, and economic bases of the biggest estate on earth, with outcomes driving the disruption of Indigenous food sovereignty, foodways and food knowledges alongside the reproduction of Whiteness. This article critically examines the place of White food, including the case of nanotechnologies, in the expansion of the settler colonial frontier, and its impacts for Indigenous health and relationships with food. To do this, we consider a widely commercialised nano-food application: the addition of nano-scale titanium dioxide to make foods White. Nano White food provides a unique lens to examine White authority and control across settler colonial food systems. We consider some of the impacts arising from this global colonial power matrix—to which Whiteness is organising principle for domination—for Aboriginal and Torres Strait Islander health, justice, and rights. We argue that unsettling Whiteness is vital to redressing the violence wrought by settler colonial agri-food systems, and for re-centring living ecologies and interconnected systems across foodways.

PURPOSE: COVID-19 brought about unprecedented challenges to healthcare, with nuclear medicine (NM) being no exception. The British Nuclear Medicine Society (BNMS) COVID-19 survey assessed the impact of the first wave of pandemic on NM services in the UK. With COVID-19 resurge compounded by seasonal winter pressures, we reflect and share lessons learnt from the first wave of pandemic to guide future strategy. METHODS: A questionnaire consisting of 34 questions was sent out to all BNMS members over 2 weeks in May 2020, to evaluate the impact of 'lockdown'. RESULTS: One hundred thirty-eight members (92 sites) from a multidisciplinary background responded. There was a 65% reduction across all services; 97.6% of respondents reported some reduction in diagnostic procedures and 71.3% reduction in therapies; 85% worked with a reduced workforce. The North East of England, Greater London and South East and Wessex were most affected by staff absences. The North East reported the highest number of COVID-19 positive staff; London reported the greatest lack of testing. The reported time required to clear the backlog was 1-12 months. Seventy-one percent of participants used BNMS COVID-19 guidance. CONCLUSION: The first wave caused a major disruption of NM service delivery and impacted on the workforce. The departmental strategies should tailor services to evolving local and regional differences in prevalence of COVID-19. A blanket shutdown of services with a 'one size fits all' strategy would likely have a severe impact on future delivery of NM and health services in general. Timely testing of staff and patients remains of paramount importance.

The institutionalisation of racism in healthcare has had a detrimental effect on the treatment and health outcomes of Aboriginal and Torres Strait Islander populations. Institutional racism describ...

Objectives The aim of the study was to identify the range of issues labeled as “non-financial conflicts of interest” in biomedicine, articulate the associated concerns, and analyze the implications of defining these issues as conflicts of interest. Study Design and Setting This was a qualitative study, triangulating data from three purposively sampled sources: (1) literature, (2) policies, and (3) interviews. Participants were corresponding authors of sampled literature (December 2017 to January 2019). A critical, interpretive approach served as the analytic strategy. Results A total of 99 articles provided the sampling frame; we recruited 16 participants and sampled 20 policies. Participants labeled a wide range of personal attributes, social relationships, professional experiences, intellectual endeavors, and financial interests as “non-financial conflicts of interest.” Despite a lack of consensus regarding the nature of the problem, many “non-financial” interests are currently subject to policy action. The term serves as ethical shorthand to describe the ways that (1) “strong beliefs,” (2) “predetermined views,” (3) experiences, and (4) relationships shape evidence-led processes. Conclusion Expansion of the definition of conflict of interest to include non-financial interests may have unintended consequences, including exclusion of diverse perspectives. Problems labeled “non-financial conflicts of interest” should be defined in terms of what they are rather than what they are not (i.e., “non”-financial). We suggest instead, preventing financial conflicts of interest and ensuring inclusive and equitable representation within evidence-based processes.

The importation of wire-fencing to Australia from the 1840s transformed the management of sheep. Rather than shepherds watching over flocks, wire-fences allowed sheep to roam relatively uns...

Consumer food ethics has re-emerged over the past 30 years as a popular form of activism to address concerns with the dominance of corporate interests in the global food system. Proponents of consumer ethics contend that informing consumers about injustices in the food system via labels or awareness campaigns will lead to collective rejection of unethical food corporations and the embrace of ethical products. This approach has been criticized on a variety of grounds, including its reliance on and eventual co-optation by market mechanisms. In response to these criticisms, food activists and scholars have promoted a consumer ethic that embraces local and alternative food systems, thereby producing an alternative consumer ethic purportedly outside of market logics. While these alternative practices have much to commend them, we argue that alternative food systems are invariably oriented towards consumer interests and thereby run into similar problems faced by earlier iterations of consumer-based ethics. We argue against the persistent focus on consumer ethics as means of substantially disrupting food systems, whether global, local or alternative.

With the advent of increased computational resources and improved algorithms, machine learning-based models are being increasingly applied to complex problems in particle accelerators. However, such data-driven models may provide overly confident predictions with unknown errors and uncertainties. For reliable deployment of machine learning models in high-regret and safety-critical systems such as particle accelerators, estimates of prediction uncertainty are needed along with accurate point predictions. In this investigation, we evaluate Bayesian neural networks (BNN) as an approach that can provide accurate predictions along with reliably quantified uncertainties for particle accelerator problems, and compare their performance with bootstrapped ensembles of neural networks. We select three accelerator setups for this evaluation: a storage ring, a photoinjector, and a linac. The problems span different data volumes and dimensionalities (e.g., scalar predictions as well as image outputs). It is found that BNN provide accurate predictions of the mean along with reliable estimates of predictive uncertainty across the test cases. In this vein, BNN may offer an attractive alternative to deterministic deep learning tools to generate accurate predictions with quantified uncertainties in particle accelerator applications.

The ever increasing demands placed upon machine performance have resulted in the need for more comprehensive particle accelerator modeling. Computer simulations are key to the success of particle accelerators. Many aspects of particle accelerators rely on computer modeling at some point, sometimes requiring complex simulation tools and massively parallel supercomputing. Examples include the modeling of beams at extreme intensities and densities (toward the quantum degeneracy limit), and with ultra-fine control (down to the level of individual particles). In the future, adaptively tuned models might also be relied upon to provide beam measurements beyond the resolution of existing diagnostics. Much time and effort has been put into creating accelerator software tools, some of which are highly successful. However, there are also shortcomings such as the general inability of existing software to be easily modified to meet changing simulation needs. In this paper possible mitigating strategies are discussed for issues faced by the accelerator community as it endeavors to produce better and more comprehensive modeling tools. This includes lack of coordination between code developers, lack of standards to make codes portable and/or reusable, lack of documentation, among others., 21 pages, 1 figure. To be published in JINST

I have been invited to reflect on "Discourse communities and the discourses of experience" a paper co-authored by Little, Jordens, and Sayers and discuss how their analysis of discourse communities has influenced the development of bioethics and consider its influence now and potential effects in the future. Their paper examines the way different discourse communities are shaped by different experiences and desires. The shared language and experiences can provide a sense of belonging and familiarity. These can be positive aspects of a discourse community, but there are also risks restricting the voices and experiences that can be heard and recognized. In this essay I hope to weave together three threads: an analysis of Little, Jordens, and Sayer's research on discourse communities; the narrative interview I conducted with Little about his own experiences in establishing a bioethics centre; and my own experience of the bioethical discourse community established by Little.

We present a novel nonlinear laser shaping technique to increase X-ray Free Electron Laser brightness and preliminary results estimate an improvement of 25% in emittance relative to the standard configuration of the LCLS-II.

The World Health Organization has recommended that Member States consider taxing energy-dense beverages and foods and/or subsidizing nutrient-rich foods to improve diets and prevent noncommunicable diseases. Numerous countries have either implemented taxes on energy-dense beverages and foods or are considering the implementation of such taxes. However, several major challenges to the implementation of fiscal policies to improve diets and prevent noncommunicable diseases remain. Some of these challenges relate to the cross-sectoral nature of the relevant interventions. For example, as health and economic policy-makers have different administrative concerns, performance indicators and priorities, they often consider different forms of evidence in their decision-making. In this paper, we describe the evidence base for diet-related interventions based on fiscal policies and consider the key questions that need to be asked by both health and economic policy-makers. From the health sector's perspective, there is most evidence for the impact of taxes and subsidies on diets, with less evidence on their impacts on body weight or health. We highlight the importance of scope, the role of industry, the use of revenue and regressive taxes in informing policy decisions.L'Organisation mondiale de la Santé a recommandé aux États membres d'envisager de taxer les boissons et aliments à haute teneur énergétique et/ou de subventionner les denrées riches en nutriments, en vue d'améliorer les régimes alimentaires et de prévenir les maladies non transmissibles. Aujourd'hui, nombreux sont les pays à avoir instauré des taxes sur les boissons et aliments à haute teneur énergétique ou à envisager de le faire. Néanmoins, d'importants défis subsistent pour la mise en application de ce type de politiques fiscales. Certains sont liés à la nature intersectorielle des interventions appropriées. Par exemple, comme les responsables des politiques économiques et les responsables des politiques de santé ont des préoccupations administratives, des priorités et des indicateurs de performances différents, ils s'appuient souvent sur différentes formes de données dans leur prise de décisions. Dans le présent document, nous décrivons les données probantes susceptibles d'orienter les interventions sur l'alimentation fondées sur des politiques fiscales et nous évoquons les principales problématiques auxquelles doivent répondre à la fois les responsables des politiques économiques et les responsables des politiques de santé. D'un point de vue de santé publique, les preuves de l'impact des taxes et subventions sur les habitudes alimentaires sont plus nombreuses que les preuves de leur impact sur le poids ou la santé. Nous abordons également l'importance du périmètre d'action, le rôle de l'industrie, l'utilisation des recettes fiscales et la régressivité des taxes, dans l'optique d'éclairer les décisions politiques.La Organización Mundial de la Salud ha recomendado a los Estados Miembros considerar la posibilidad de aplicar un impuesto a las bebidas y los alimentos de alto contenido energético y/o subvencionar los alimentos ricos en nutrientes para mejorar las dietas y prevenir enfermedades no contagiosas. Numerosos países ya aplican impuestos a bebidas y alimentos de alto contenido energético o consideran la implementación de dichos impuestos. Sin embargo, persisten varios desafíos importantes para la implementación de políticas fiscales para mejorar las dietas y prevenir las enfermedades no contagiosas. Algunos de estos desafíos están relacionados con la naturaleza intersectorial de las intervenciones correspondientes. Por ejemplo, puesto que los encargados de la formulación de políticas de salud y economía tienen diferentes preocupaciones administrativas, indicadores de rendimiento y prioridades, a menudo tienen en cuenta diferentes formas de pruebas en su toma de decisiones. En este documento, se describe la base de pruebas para intervenciones relacionadas con la dieta basadas en políticas fiscales y se consideran las preguntas clave que deben formular tanto los responsables de la política económica como de la de salud. Desde la perspectiva del sector de la salud, existen muchas pruebas del impacto de los impuestos y subsidios en las dietas, con menos pruebas de sus impactos sobre el peso o la salud corporal. Se destaca la importancia del alcance, el papel de la industria, el uso de los ingresos y los impuestos regresivos para informar sobre las decisiones políticas.أوصت منظمة الصحة العالمية الدول الأعضاء بدراسة فرض ضرائب على المشروبات والأطعمة كثيرة السعرات الحرارية و/أو دعم الأطعمة الغنية بالمغذيات وذلك من أجل تحسين الأنظمة الغذائية ومقاومة الأمراض غير المعدية. وقد قامت العديد من البلدان بفرض الضرائب بالفعل على المشروبات والأطعمة كثيرة السعرات الحرارية أو تدرس فرض ضرائب من هذا النوع، إلا أن العديد من التحديات الرئيسية تواجه تنفيذ السياسات المالية لتحسين الأنظمة الغذائية والوقاية من الأمراض غير المعدية. وتتعلق بعض هذه التحديات بطبيعة التدخلات ذات الصلة والمشتملة على عدة قطاعات. على سبيل المثال، فإن تباين الاهتمامات الإدارية ومؤشرات الأداء والأولويات لدى مقرري السياسات الاقتصادية والصحية غالبًا ما يدفعهم إلى اعتماد أشكال مختلفة للأسس الدلالية التي يستندون إليها في عملية اتخاذ القرار. ونصف في هذا التقرير الأساس الدلالي للتدخلات ذات الصلة بالأنظمة الغذائية والمعتمدة على السياسات المالية، ونبحث الأسئلة الرئيسية الوارد طرحها من جانب من كلٍ من مقرري السياسات الاقتصادية والصحية. ومن منظور القطاع الصحي تشير معظم الدلائل إلى حدوث تأثير ناتج عن فرض الضرائب والدعم على الأنظمة الغذائية، في حين توجد دلائل أقل تشير إلى تأثيرها على وزن الجسم أو الصحة. ونحن نقوم بتسليط الضوء على أهمية النطاق ودور الصناعة والاستفادة من الإيرادات والضرائب التنازلية في اتخاذ القرارات المستنيرة المتعلقة بالسياسات.世界卫生组织建议会员国考虑对高能量饮料和食品征税和/或给予富含营养物质的食品补贴，以改善饮食和预防非传染性疾病。许多国家要么已经对高能量饮料和食品征税，要么正在考虑实施此项税赋。但是，实施改善饮食和预防非传染性疾病的财政政策仍然面临若干重大挑战。其中一些挑战与相关干预的跨部门性质有关。例如，由于卫生和经济决策者的行政关注、绩效指标和优先事项有所不同，决策者在制定决策时往往会考虑不同形式的依据。在本文中，我们描述了基于财政政策的饮食相关干预的依据基础，并考虑了卫生和经济决策者都需要提出的关键问题。从卫生部门的角度来看，很多依据可以证明税收和补贴对饮食的影响，但很少有依据可以证明其对体重或健康的影响。我们强调了范围、行业角色、营业税和累退税的使用在传达政治决策中的重要性。.Всемирная организация здравоохранения рекомендовала государствам-членам рассмотреть вопрос об обложении налогом высококалорийных напитков и продуктов питания и (или) субсидировании богатых питательными веществами продуктов питания для улучшения рациона и профилактики неинфекционных заболеваний. Многие страны либо применяют налоги на высококалорийные напитки и продукты питания, либо рассматривают возможность применения таких налогов. Тем не менее остается несколько серьезных проблем, связанных с осуществлением налогово-бюджетной политики, направленной на улучшение рациона и профилактику неинфекционных заболеваний. Некоторые из этих проблем связаны с межсекторальным характером соответствующих интервенций. Например, поскольку лица, определяющие политику в области здравоохранения и экономики, имеют разные по характеру административные проблемы, показатели эффективности и приоритеты, они часто учитывают различные формы доказательных данных в процессе принятия решений. В этой статье мы описываем доказательную базу для связанных с рационом интервенций на основе налогово-бюджетной политики и рассматриваем ключевые вопросы, которыми должны задаваться лица, определяющие политику в области здравоохранения и экономики. С точки зрения сектора здравоохранения имеется больше данных о влиянии налогов и субсидий на рацион при меньшем объеме данных об их воздействии на вес тела или здоровье. Мы подчеркиваем важность сферы применения, роли промышленности, использования доходов и регрессивных налогов для принятия политических решений.

Machine learning models of accelerator systems (`surrogate models') are able to provide fast, accurate predictions of accelerator physics phenomena. However, approaches to date typically do not include measured input diagnostics, such as the initial beam distributions, which are critical for accurately representing the beam evolution through the system. In addition, these inputs often vary over time, and models that can account for these changing conditions are needed. Simulations are in some cases needed to provide sufficient training data. These typically represent the designed machine before construction; however, the behavior of the installed components may be quite different due to changes over time or static differences that were not modeled. Therefore, surrogate models that can leverage both simulation and measured data successfully are needed. We introduce an approach based on convolutional neural networks that uses the drive laser distribution and scalar settings as inputs for the Linac Coherent Light Source II injector frontend. The model is able to predict scalar beam parameters and the transverse beam distribution downstream, taking into account the impact of time-varying non-uniformities in the initial transverse laser distribution. We also introduce and evaluate a transfer learning procedure for adapting the surrogate model from the simulation domain to the measurement domain, to account for differences between the two. Applying this approach to our test case results in a model that can predict test sample outputs within a mean absolute percent error of 7.6%. This is a substantial improvement over the model trained only on simulations, which has an error of 112.7% when applied to measured data. While we focus on the LCLS-II Injector frontend, these approaches for improving ML-based online modeling of injector systems could be easily adapted to other accelerator facilities., 17 pages, 23 figures

Aim This paper reports on the findings from 6 focus groups conducted with Australian medical students. The focus groups sought students' perspectives on how the influence of commercial interests on medical practice and education could be managed. Method We conducted 6 focus groups with medical students in New South Wales, Australia. Participants were recruited via student-run medical society and faculty e-mail lists. Forty-nine students from 6 medical schools in New South Wales participated. The research team reflected on the extent to which students uncritically appealed to science in the abstract as a management solution for conflicts of interest. Data analysis was largely inductive, looking for uses of scientific terminology, EBM, and appeals to “science” in the management of COI and applied theoretical analyses of scientism. Results The students in our study suggested that science and evidence-based medicine, rather than ethics or professionalism, were the best tools to deal with undue influence and bias. This paper uses philosophy of science literature to critically examine these scientistic appeals to science and EBM as a means of managing the influence of pharmaceutical reps and commercial interests. We argue that a scientistic style of reasoning is reinforced through medical curricula and that students need to be made aware of the epistemological assumptions that underpin science, medicine, and EBM to address the ethical challenges associated with commercialised health care. Conclusion More work is needed to structure medical curricula to reflect the complexities of practice and realities of science. However, curricula change alone will not sufficiently address issues associated with commercial interests in medicine. For real change to occur, there needs to be a broader social and professional debate about the ways in which medicine and industry interact, and structural changes that restrict or mitigate commercial influences in educational, research, and policy settings.

Over the past decade ‘social egg freezing’ has emerged as a technology of hope that purports to empower women by enabling them to continue their careers or find the right partner without the fear of jeopardising their fertility. This technology has been promoted and celebrated by fertility companies, bioethicists, clinicians, and multi-national corporations such as Apple and Facebook. While critical questions have been raised, they tend to focus on ethical and legal issues, such as informed consent and patient autonomy. This paper uses Foucault’s notion of dispositif as analytic lens to examine the entanglement of the commercial arrangements of fertility companies, the discursive use of hope in promoting these services, and effects on professional medical care. Drawing on socio-political analyses of hope, this paper examines the potential financial conflicts of interest facing clinicians and the way discourses of hope might mask problematic financial relations and lack of evidence of effectiveness.

Conflicts of interest (COI) are considered ubiquitous in many healthcare arrangements,1 but there is disagreement on how COI should be defined, whether non-financial conflicts deserve attention and the relationship between COI and harm. We conducted a study of Australian healthcare professionals and students to gain a better understanding of the way that COI are understood in practice. In this paper, we outline an empirically derived taxonomy of the understanding of, and attitudes towards, COI. We carried out 25 semistructured interviews with clinicians working in several fields across Australia and held six focus group discussions with medical students in New South Wales. Interviewees and focus groups followed similar question routes investigating participants' understanding of COI and views of management. All data were compared and analysed using a matrix of pre-determined questions. There were, broadly, two views of COI: that COI were potentially harmful and morally compromising and another that saw COI as less serious and easily managed through existing structures. Definitions of COI varied widely and were both financial and non-financial. Causes of COI were, variously, systemic, individual and/or relational. Some participants associated COI with moral wrongdoing, and a variety of potential harms was identified. Views on how COI should be managed were similarly varied. We found considerable heterogeneity in how COI are understood in practice. This has implications for management systems that are currently in place, and we suggest a more sophisticated system for considering and mitigating COI.

We consider the role of codes of ethics in social marketing, distinguishing between “procedural ethics” and “ethics-in-practice” (after Guillemin & Gillam, 2004). We review foundations for “procedural ethics”—formal systems for ethical oversight—including moral and political philosophy, existing codes of ethics, and previous proposals for codes of ethics for social marketing. We then discuss “ethics-in-practice,” the ethical dimensions of the small moments that comprise everyday life. We connect this idea to Aristotle’s concept of phronesis, the practical wisdom to respond in just the right way to particular situations. Supporting the ethical practice of social marketing will require both procedural ethics and ethics-in-practice, iteratively related to one another. We conclude with three tasks for the profession: (1) develop and apply norms, standards, and sanctions; (2) develop formal, procedural ethics, in a just way (e.g., codes of ethics); and (3) support social marketers to develop ethics-in-...

This paper critically examines the proliferation of conflicts of interest (COI) discourse and how the most common conceptions of COI presuppose a hierarchy of primary and secondary interests. I show that a form of professional virtue or duty is commonly employed to give the primary interest normative force. However, I argue that in the context of increasingly commercialized healthcare neither virtue nor duty can do the normative work expected of them. Furthermore, I suggest that COI discourse is symptom of rather than solution to the problems of market forces in contemporary medicine. I contend that COI, as it is commonly conceived, is an inadequate concept through which to attend to these problems. It is used as a procedural short-cut to address ethico-political problems. That is, it is an economic and policy concept expected to do significant moral and political work. Like most short-cuts, this one also leads to entanglements and winding roads that fail to reach the destination. As such, I suggest that we need a different set of ethico-political tools to address normative fluidity of medical practice in the absence on a primary interest.

High-fidelity physics simulations are powerful tools in the design and optimization of charged particle accelerators. However, the computational burden of these simulations often limits their use in practice for design optimization and experiment planning. It also precludes their use as online models tied directly to accelerator operation. We introduce an approach based on machine learning to create nonlinear, fast-executing surrogate models that are informed by a sparse sampling of the physics simulation. The models are 10^6 to 10^7 times more efficient to execute.We also demonstrate that these models can be reliably used with multi-objective optimization to obtain orders-of-magnitude speedup in initial design studies and experiment planning. For example, we required 132 times fewer simulation evaluations to obtain an equivalent solution for our main test case, and initial studies suggest that between 330 to 550 times fewer simulation evaluations are needed when using an iterative retraining process. Our approach enables new ways for high-fidelity particle accelerator simulations to be used, at comparatively little computational cost., Comment: under review for publication

Social, political, and economic environments play an active role in nurturing professional virtue. Yet, these environments can also lead to the erosion of virtue. As such, professional virtue is fragile and vulnerable to environmental shifts. While physicians are often considered to be among the most virtuous of professional groups, concern has also always existed about the impact of commercial arrangements on physicians' willingness and capacity to enact their professional virtues. This article examines the ways in which commercial arrangements have been negotiated to secure medical virtue from real or perceived threats of erosion. In particular, we focus on the concern surrounding conflicts of interest arising from commercial arrangements that have developed as a result of neoliberal economic and social policies. The deregulation of medical markets and privatization of services have produced new commercial relationships that are often misunderstood by patients, publics, and physicians themselves. 'Conflicts of interest' policies have been introduced in an attempt to safeguard ethical conduct and medical practice. However, a number of virtue ethicists have critiqued these policies as inadequate for securing virtue. We examine the ways in which commercial arrangements have been seen to impact upon medical virtue, both historically and in the context of modern medicine (using the example of fertility services in Australia). We then describe and critique current efforts to restore clinical virtue through both conflict of interest policies and through virtue ethics. Finally, we suggest some possible ways of addressing the corrosive effects of neoliberalism on medical virtue. Refereed/Peer-reviewed

At once historical and philosophical, Michel Foucault used his genealogical method to expose the contingent conditions constituting the institutions, sciences and practices of the present. His analyses of the asylum, clinic, prison and sexuality revealed the historical, political and epistemological forces that make up certain types of subjects, sciences and sites of control. Although noting the originality of his work, a number of early critics questioned the normative framework of Foucault's method. Nancy Fraser argued that Foucault's genealogical method was ‘normatively confused’ as it implied political critique yet claimed to be value-neutral. Jurgen Habermas and Charles Taylor also questioned the normative basis of Foucault's appeals to critique, arguing it was self-refuting as Foucault left no room for the subject to escape power. Although a debate among these scholars was planned for the mid-1980s, Foucault's death in 1984 meant this could not occur. A number of edited volumes sought to fabricate a debate, with defenders of Foucault excavating his published monographs to construct responses to his critics. While the monographs remain the central texts of Foucault's oeuvre, over the past decade his College de France lectures have been published and translated into English. This article offers a schematic survey of the influence of the College de France lectures in recasting different points in the debates over normativity, critique and resistance.

The LCLS-II free-electron laser will be an upgrade of the existing Linac Coherent Light Source (LCLS), including a 4 GeV CW superconducting linac based on the TESLA technology. The high quality factor of the cavity makes it very sensitive to vibrations. The shift of its eigenfrequency (i.e., detuning) will be compensated by the power source in order to assure a constant accelerating voltage. Significant variations of the forward power are expected which result in coupler kick variations induced by the fundamental power coupler. In this work we estimate the magnitude of trajectory jitter caused by these variations. High precision 3D field maps including standing and traveling-wave components for a cavity with the LCLS-II coupler design are presented., Proceedings of the 9th Int. Particle Accelerator Conf., IPAC2018, Vancouver, BC, Canada

This article critically examines current responses to multi-drug resistant tuberculosis and argues that bioethics needs to be willing to engage in a more radical critique of the problem than is currently offered. In particular, we need to focus not simply on market-driven models of innovation and anti-microbial solutions to emergent and re-emergent infections such as TB. The global community also needs to address poverty and the structural factors that entrench inequalities—thus moving beyond the orthodox medical/public health frame of reference. in part funded by the NHMRC CRE for TB Control [CRE1043225]

In Australia, the growing assisted reproductive technologies (ART) industry has recently received some public criticism. Much of this criticism centres on the concern that doctors are increasingly motivated by profit, rather than patient interests. These concerns appear to suggest that the growing business of ART generates conflicts of interest (COI) for clinicians. While media reports may be rhetorically compelling, claims that ART practice is distorted by COI must be supported by empirical evidence. This preliminary study sought to engage with people involved with the ART industry and map out their concerns related to COI in ART. A small convenience sample of eight professionals was interviewed. Here, we present the major themes uncovered, including a richer understanding of the 'interests' of various parties involved in Australian ART. We then propose a strategy for how this topic could be constructively explored.