1. Spatial distribution of MRI-determined hepatic proton density fat fraction in adults with nonalcoholic fatty liver disease
- Author
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An Tang, Tanya Wolfson, Christopher Changchien, Arian Mashhood, Lisa Clark, Rohit Loomba, Susanne Bonekamp, Anthony Gamst, Michael S. Middleton, and Claude B. Sirlin
- Subjects
medicine.medical_specialty ,Multivariable linear regression ,Fat content ,business.industry ,Liver segment ,Proton density fat fraction ,medicine.disease ,Endocrinology ,Internal medicine ,Nonalcoholic fatty liver disease ,Liver fat ,Health insurance ,medicine ,Population study ,Radiology, Nuclear Medicine and imaging ,Nuclear medicine ,business - Abstract
Author(s): Bonekamp, Susanne; Bonekamp, Susanne; Tang, An; Mashhood, Arian; Wolfson, Tanya; Changchien, Christopher; Middleton, Michael S; Clark, Lisa; Gamst, Anthony; Loomba, Rohit; Sirlin, Claude B | Abstract: PurposeTo describe the spatial distribution of liver fat,using MRI-estimated proton density fat fraction (PDFF), in adults with nonalcoholic fatty liver disease (NAFLD).Materials and methodsThis Investigational Review Board-approved, Health Insurance Portability and Accountability Act-compliant study prospectively enrolled 50 adults (30 women, 20 men) with biopsy-proven NAFLD. Hepatic PDFF was measured by low-flip-angle multiecho spoiled gradient-recalled-echo MRI at 3 Tesla. Three nonoverlapping regions of interest were placed within each liver segment. Statistical analyses included Pearson's correlation, multivariable linear regression, and permutation-based paired tests.ResultsThe study population's mean whole-liver PDFF was 16.1% (range: 1.6–39.6%). The mean whole-liver PDFF variability was 1.9% (range: 0.7–4.5%). Higher variability was associated with higher PDFF (r=0.34;P=0.0156). The mean PDFF was significantly higher in the right lobe than the left (16.5% versus 15.3%, P=0.0028). The mean PDFF variability was higher in the left lobe than the right (1.86% versus 1.28%; Pl0.0001). Segment II had the lowest mean segmental PDFF (14.8%);segment VIII had the highest (16.7%). Segments V(0.71%) and VI (0.70%) had the lowest mean segmental PDFF variability; segment II had the highest (1.32%).ConclusionIN adult NAFLD there are small but significant differences in fat content.
- Published
- 2013