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13 results on '"Christmann, Rebekka"'

1. Tape Stripping

Author

Christmann, Rebekka, primary, Raber, Anne S., additional, Schaefer, Ulrich F., additional, Melero, Ana, additional, and Loretz, Brigitta, additional

Published
2021
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3. Pseudomonas aeruginosa Biofilm: A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms (Adv. Sci. 12/2021)

Author

Schütz, Christian, primary, Ho, Duy‐Khiet, additional, Hamed, Mostafa Mohamed, additional, Abdelsamie, Ahmed Saad, additional, Röhrig, Teresa, additional, Herr, Christian, additional, Kany, Andreas Martin, additional, Rox, Katharina, additional, Schmelz, Stefan, additional, Siebenbürger, Lorenz, additional, Wirth, Marius, additional, Börger, Carsten, additional, Yahiaoui, Samir, additional, Bals, Robert, additional, Scrima, Andrea, additional, Blankenfeldt, Wulf, additional, Horstmann, Justus Constantin, additional, Christmann, Rebekka, additional, Murgia, Xabier, additional, Koch, Marcus, additional, Berwanger, Aylin, additional, Loretz, Brigitta, additional, Hirsch, Anna Katharina Herta, additional, Hartmann, Rolf Wolfgang, additional, Lehr, Claus‐Michael, additional, and Empting, Martin, additional

Published
2021
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4. A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms

Author

Schütz, Christian, primary, Ho, Duy‐Khiet, additional, Hamed, Mostafa Mohamed, additional, Abdelsamie, Ahmed Saad, additional, Röhrig, Teresa, additional, Herr, Christian, additional, Kany, Andreas Martin, additional, Rox, Katharina, additional, Schmelz, Stefan, additional, Siebenbürger, Lorenz, additional, Wirth, Marius, additional, Börger, Carsten, additional, Yahiaoui, Samir, additional, Bals, Robert, additional, Scrima, Andrea, additional, Blankenfeldt, Wulf, additional, Horstmann, Justus Constantin, additional, Christmann, Rebekka, additional, Murgia, Xabier, additional, Koch, Marcus, additional, Berwanger, Aylin, additional, Loretz, Brigitta, additional, Hirsch, Anna Katharina Herta, additional, Hartmann, Rolf Wolfgang, additional, Lehr, Claus‐Michael, additional, and Empting, Martin, additional

Published
2021
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7. Synthesis and Biopharmaceutical Characterization of Amphiphilic Squalenyl Derivative Based Versatile Drug Delivery Platform

Author

Ho, Duy-Khiet, primary, Christmann, Rebekka, additional, Murgia, Xabier, additional, De Rossi, Chiara, additional, Frisch, Sarah, additional, Koch, Marcus, additional, Schaefer, Ulrich F., additional, Loretz, Brigitta, additional, Desmaele, Didier, additional, Couvreur, Patrick, additional, and Lehr, Claus-Michael, additional

Published
2020
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8. Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections

Author

Ho, Duy‐Khiet, primary, Murgia, Xabier, additional, De Rossi, Chiara, additional, Christmann, Rebekka, additional, Hüfner de Mello Martins, Antonio G., additional, Koch, Marcus, additional, Andreas, Anastasia, additional, Herrmann, Jennifer, additional, Müller, Rolf, additional, Empting, Martin, additional, Hartmann, Rolf W., additional, Desmaele, Didier, additional, Loretz, Brigitta, additional, Couvreur, Patrick, additional, and Lehr, Claus‐Michael, additional

Published
2020
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9. Cover Picture: Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections (Angew. Chem. Int. Ed. 26/2020)

Author

Ho, Duy‐Khiet, primary, Murgia, Xabier, additional, De Rossi, Chiara, additional, Christmann, Rebekka, additional, Hüfner de Mello Martins, Antonio G., additional, Koch, Marcus, additional, Andreas, Anastasia, additional, Herrmann, Jennifer, additional, Müller, Rolf, additional, Empting, Martin, additional, Hartmann, Rolf W., additional, Desmaele, Didier, additional, Loretz, Brigitta, additional, Couvreur, Patrick, additional, and Lehr, Claus‐Michael, additional

Published
2020
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10. Titelbild: Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections (Angew. Chem. 26/2020)

Author

Ho, Duy‐Khiet, primary, Murgia, Xabier, additional, De Rossi, Chiara, additional, Christmann, Rebekka, additional, Hüfner de Mello Martins, Antonio G., additional, Koch, Marcus, additional, Andreas, Anastasia, additional, Herrmann, Jennifer, additional, Müller, Rolf, additional, Empting, Martin, additional, Hartmann, Rolf W., additional, Desmaele, Didier, additional, Loretz, Brigitta, additional, Couvreur, Patrick, additional, and Lehr, Claus‐Michael, additional

Published
2020
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11. Tofacitinib Loaded Squalenyl Nanoparticles for Targeted Follicular Delivery in Inflammatory Skin Diseases

Author

Christmann, Rebekka, Ho, Duy-Khiet, Wilzopolski, Jenny, Lee, Sangeun, Koch, Marcus, Loretz, Brigitta, Vogt, Thomas, Bäumer, Wolfgang, Schaefer, Ulrich F., Lehr, Claus-Michael, and HIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.

Subjects
integumentary system, hair follicle, in vivo allergic dermatitis mouse model, lcsh:RS1-441, squalene, follicular delivery, Article, targeted drug delivery, lcsh:Pharmacy and materia medica, nanoparticles, skin and connective tissue diseases, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik, interfollicular delivery
Abstract

Tofacitinib (TFB), a Janus kinase inhibitor, has shown excellent success off-label in treating various dermatological diseases, especially alopecia areata (AA). However, TFB&rsquo, s safe and targeted delivery into hair follicles (HFs) is highly desirable due to its systemic adverse effects. Nanoparticles (NPs) can enhance targeted follicular drug delivery and minimize interfollicular permeation and thereby reduce systemic drug exposure. In this study, we report a facile method to assemble the stable and uniform 240 nm TFB loaded squalenyl derivative (SqD) nanoparticles (TFB SqD NPs) in aqueous solution, which allowed an excellent loading capacity (LC) of 20%. The SqD NPs showed an enhanced TFB delivery into HFs compared to the aqueous formulations of plain drug in an ex vivo pig ear model. Furthermore, the therapeutic efficacy of the TFB SqD NPs was studied in a mouse model of allergic dermatitis by ear swelling reduction and compared to TFB dissolved in a non-aqueous mixture of acetone and DMSO (7:1 v/v). Whereas such formulation would not be acceptable for use in the clinic, the TFB SqD NPs dispersed in water illustrated a better reduction in inflammatory effects than plain TFB&rsquo, s aqueous formulation, implying both encouraging good in vivo efficacy and safety. These findings support the potential of TFB SqD NPs for developing a long-term topical therapy of AA.

Published
2020
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12. Follicular targeted drug delivery via nanocarriers in the treatment of (auto)inflammatory skin diseases

Author

Christmann, Rebekka

Abstract

Today, it is widely known that nanoparticles (NPs) maximize follicular and minimize interfollicular drug delivery, thereby reducing systemic drug levels and severe side effects. Non-life-threatening skin diseases, like Alopecia Areata (AA), a reversible hair loss disorder associated with major negative effect on quality of life, lack of sufficient treatment, among other things caused by negative risk-benefit profiles of potent drugs such as Janus Kinase inhibitors, e.g., tofacitinib (TFB). Therefore, NPs are predestined to enable a targeted drug delivery into hair follicles (HFs) for a safer treatment against skin diseases like AA. As proof of concept, the NP deposition inside human scalp HFs was studied by adjustment of a quantification method for human forearm HFs. Investigations on healthy human, AAaffected hairless and hairy body donor scalp HFs showed that NP uptake into HFs depends on follicular density but is independent of hair shaft presence and hair type. Accordingly, TFB-loaded NPs were developed. Previously-synthesized squalenyl derivative NPs exceeded other approaches, demonstrating high drug loading capacity, biocompatibility, colloidal stability, and enhanced follicular delivery in an ex vivo pig ear model, which was supported by a biological effect in an in vivo dermatitis mouse model. Further investigations on follicular targeted delivery via NPs for a safe and potent treatment of skin diseases, leading to translation into the clinics, are highly desired.

Published
2021

13. Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections

Author

Ho, Duy-Khiet, Murgia, Xabier, De Rossi, Chiara, Christmann, Rebekka, Hüfner De Mello Martins, Antonio G., Koch, Marcus, Andreas, Anastasia, Herrmann, Jennifer, Müller, Rolf, Empting, Martin, Hartmann, Rolf W., Desmaele, Didier, Loretz, Brigitta, Couvreur, Patrick, and Lehr, Claus-Michael

Subjects
3. Good health

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