1. Recapitulation of HIV-1 Env-Antibody Coevolution in Macaques Leading to Neutralization Breadth
- Author
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Shuyi Wang, Chengyan Zhao, Anya M. Bauer, Fang-Hua Lee, Cara W. Chao, Emily Lindemuth, Nicole A. Doria-Rose, Juliette Rando, Frederic Bibollet-Ruche, Kevin Wiehe, Mario Roederer, Chaim A. Schramm, Bette T. Korber, Donald D. Raymond, Kwan-Ki Hwang, Weimin Liu, George M. Shaw, Mark G. Lewis, Ronnie M. Russell, Hui Li, Stephen C. Harrison, Baoshan Zhang, Ryan S. Roark, Andrew G. Smith, Jesse Connell, Kevin O. Saunders, Hui Geng, Alexander I. Murphy, Mattia Bonsignori, Elena E. Giorgi, Maho Okumura, Hema Chug, Beatrice H. Hahn, John R. Mascola, Peter D. Kwong, Peter T. Hraber, Christina Rosario, Jessica G. Smith, David R. Ambrozak, Yu Ding, Wenge Ding, Richard Nguyen, Rosemarie D. Mason, Barton F. Haynes, Mark K. Louder, Daniel C. Douek, Kshitij Wagh, Jason Gorman, Bob C. Lin, Thomas B. Kepler, Wilton B. Williams, Neha Chohan, Garnett Kelsoe, Gwo-Yu Chuang, Julia DeVoto, Katharine J. Bar, and M. Anthony Moody
- Subjects
0301 basic medicine ,Immunogen ,viruses ,Human immunodeficiency virus (HIV) ,HIV Infections ,HIV Antibodies ,HIV Envelope Protein gp120 ,Biology ,Virus Replication ,medicine.disease_cause ,Article ,Epitope ,Neutralization ,Biological Coevolution ,Epitopes ,03 medical and health sciences ,0302 clinical medicine ,Viral envelope ,medicine ,Animals ,Humans ,Binding site ,Immunodeficiency ,Coevolution ,Binding Sites ,Multidisciplinary ,Cryoelectron Microscopy ,Molecular Mimicry ,virus diseases ,medicine.disease ,Macaca mulatta ,Virology ,030104 developmental biology ,Viral replication ,CD4 Antigens ,HIV-1 ,biology.protein ,Simian Immunodeficiency Virus ,Antibody ,Viral persistence ,Broadly Neutralizing Antibodies ,030217 neurology & neurosurgery - Abstract
Convergent HIV evolution across species Human immunodeficiency virus (HIV) has a highly diverse envelope protein that it uses to target human cells, and the complexity of the viral envelope has stymied vaccine development. Roark et al. report that the immediate and short-term evolutionary potential of the HIV envelope is constrained because of a number of essential functions, including antibody escape. Consequently, when introduced into humans as HIV or into rhesus macaque monkeys as chimeric simian-human immunodeficiency virus, homologous envelope glycoproteins appear to exhibit conserved patterns of sequence evolution, in some cases eliciting broadly neutralizing antibodies in both hosts. Conserved patterns of envelope variation and homologous B cell responses in humans and monkeys represent examples of convergent evolution that may serve to guide HIV vaccine development. Science , this issue p. eabd2638
- Published
- 2020