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3. Última generación de prótesis percutáneas expandibles con balón y autoexpandibles en la estenosis aórtica bicúspide: estudio TRITON

Author

Ignacio J. Amat-Santos, Mario García-Gómez, Federico de Marco, Kim Won-Keun, Joao Brito, Jonathan Halim, John Jose, Gunasekaran Sengotuvelu, Ashok Seth, Christian Terkelsen, Marcin Protasiewicz, Nelson Bonilla, Bruno García, Juan Pablo Sánchez-Luna, Sara Blasco-Turrión, José Carlos González, Esther González-Bartol, Alexander J.J. Ijsselmuiden, Itziar Gómez-Salvador, Manuel Carrasco Moraleja, and Alberto San Román

Subjects
Cardiology and Cardiovascular Medicine
Published
2023
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4. Latest-iteration balloon- and self-expandable transcatheter valves for severe bicuspid aortic stenosis: the TRITON study

Author

Ignacio J. Amat-Santos, Mario García-Gómez, Federico de Marco, Kim Won-Keun, Joao Brito, Jonathan Halim, John Jose, Gunasekaran Sengotuvelu, Ashok Seth, Christian Terkelsen, Marcin Protasiewicz, Nelson Bonilla, Bruno García, Juan Pablo Sánchez-Luna, Sara Blasco-Turrión, José Carlos González, Esther González-Bartol, Alexander J.J. Ijsselmuiden, Itziar Gómez-Salvador, Manuel Carrasco Moraleja, and Alberto San Román

Subjects
General Medicine
Published
2023
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5. Clinical outcomes of no stenting in patients with ST-segment elevation myocardial infarction undergoing deferred primary percutaneous coronary intervention

Author

Madsen, Jasmine Madsen, primary, Kelbæk, Henning, additional, Nepper-Christensen, Lars, additional, Jacobsen, Mia Jacobsen, additional, Ahtarovski, Kiril Aleksov, additional, Høfsten, Dan Høfsten, additional, Holmvang, Lene, additional, Pedersen, Frants, additional, Tilsted, Hans-Henrik, additional, Aarøe, Jens, additional, Jensen, Svend Eggert, additional, Raungaard, Bent, additional, Terkelsen, Christian Terkelsen, additional, Køber, Lars, additional, Engstrøm, Thomas, additional, and Lønborg, Jacob Lønborg, additional

Published
2022
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6. Clinical outcomes of no stenting in patients with ST-segment elevation myocardial infarction undergoing deferred primary percutaneous coronary intervention

Author

Jasmine Madsen Madsen, Henning Kelbæk, Lars Nepper-Christensen, Mia Jacobsen Jacobsen, Kiril Aleksov Ahtarovski, Dan Høfsten Høfsten, Lene Holmvang, Frants Pedersen, Hans-Henrik Tilsted, Jens Aarøe, Svend Eggert Jensen, Bent Raungaard, Christian Terkelsen Terkelsen, Lars Køber, Thomas Engstrøm, and Jacob Lønborg Lønborg

Subjects
Percutaneous Coronary Intervention/methods, plaque rupture, risk stratification, Constriction, Pathologic, equipment and supplies, STEMI, surgical procedures, operative, Percutaneous Coronary Intervention, Treatment Outcome, ST Elevation Myocardial Infarction/surgery, Humans, ST Elevation Myocardial Infarction, Stents, cardiovascular diseases, Cardiology and Cardiovascular Medicine
Abstract

BACKGROUND: ST-segment elevation myocardial infarction (STEMI) is treated with stenting, but the underlying stenosis is often not severe, and stenting may potentially be omitted.AIMS: The aim of the study was to investigate outcomes of patients with STEMI treated with percutaneous coronary intervention (PCI) without stenting.METHODS: Patients were identified through the DANAMI-3-DEFER study. Stenting was omitted in the patients with stable flow after initial PCI and no significant residual stenosis on the deferral procedure, who were randomised to deferred stenting. These patients were compared to patients randomised to conventional PCI treated with immediate stenting. The primary endpoint was a composite of all-cause mortality, recurrent myocardial infarction (MI), and target vessel revascularisation (TVR).RESULTS: Of 603 patients randomised to deferred stenting, 84 were treated without stenting, and in patients randomised to conventional PCI (n=612), 590 were treated with immediate stenting. Patients treated with no stenting had a median stenosis of 40%, median vessel diameter of 2.9 mm, and median lesion length of 11.4 mm. During a median follow-up of 3.4 years, the composite endpoint occurred in 14% and 16% in the no and immediate stenting groups, respectively (unadjusted hazard ratio [HR] 0.87, 95% confidence interval [CI]: 0.48-1.60; p=0.66). The association remained non-significant after adjusting for confounders (adjusted HR 0.53, 95% CI: 0.22-1.24; p=0.14). The rates of TVR and recurrent MI were 2% vs 4% (p=0.70) and 4% vs 6% (p=0.43), respectively.CONCLUSIONS: Patients with STEMI, with no significant residual stenosis and stable flow after initial PCI, treated without stenting, had comparable event rates to patients treated with immediate stenting.

Published
2022
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7. Membranous septum morphology and risk of conduction abnormalities after transcatheter aortic valve implantation

Author

Jørgensen, Troels Jørgensen, primary, Hansson, Nicolaj, additional, De Backer, Ole, additional, Bieliauskas, Gintautas, additional, Terkelsen, Christian Terkelsen, additional, Wang, Xi, additional, Jensen, Jesper Jensen, additional, Christiansen, Evald Christiansen, additional, Piazza, Nicolo, additional, Svendsen, Jesper Svendsen, additional, Nørgaard, Bjarne Nørgaard, additional, and Søndergaard, Lars, additional

Published
2022
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9. Stable water isotope variability as a proxy of past temperatures:Using polar ice cores as a climate archive

Author

Holme, Christian Terkelsen and Holme, Christian Terkelsen

Abstract

The stable water isotope signal (d18O and dD) of polar ice cores can be employed as a proxy of the local temperature history. However, it has proven to be challenging to quantify the magnitude of past temperature change solely from the measured isotopic composition. Thus, in a pursuit of improving the accuracy of temperature reconstructions, this PhD dissertation investigates some of the paleoclimatic interpretations that can be made from ice core d18O and dD variability. The work has led to two published papers and one submitted manuscript, all presented in this thesis. The first study presents temperature reconstruction techniques that only depend on the magnitude of diffusive smoothing on the d18O and dD signals. The objective is to evaluate the performance of such diffusion-based reconstruction techniques in terms of accuracy and precision. By utilizing the methods on both synthetic generated data and ice core data from Greenland and Antarctica, the study finds that single diffusion approaches have higher precision (1.1C) than methods that rely on the differential diffused signal of d18O and dD (1.9C). The second study examines how to estimate the diffusion length from power spectra of newer, continuously measured water isotope data sets that have lower instrument noise levels. Such power spectra reveal a deviation from the conventional power spectral structure, which complicates the currently used diffusion estimation approaches. By performing tests with synthetic data, the results show that noise and system smoothing occurring through the continuous flow analysis system can explain the observed power spectra. This led to the proposal of two modified techniques that can be used to estimate the diffusion length of continuously measured water isotopes. The third study analyzes the d18O variability of three ice cores drilled on Renland, East Greenland. The objective is to examine their common signal and how it correlates with regional temperatures back in time. Wh

Published
2019

11. TCT-90 Clinical Outcomes Three Year After Revascularization With a Biodegradable Polymer Ultra-thin Strut Sirolimus-eluting Stent and a Biodegradable Polymer Biolimus-eluting Stent. From the SORT OUT VII trial

Author

Julia Ellert, Lisette Okkels Jensen, Michael Maeng, Bent Raungaard, Christian Terkelsen, Knud Hansen, Johnny Kahlert, Svend Eggert Jensen, Hans Erik Bøtker, Henrik Hansen, Jens Aaroe, Steen Dalby Kristensen, Jens Lassen, Karsten Veien, and Evald Christiansen

Subjects
Cardiology and Cardiovascular Medicine
Published
2018
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15. Initial results from geophysical surveys and shallow coring of the Northeast Greenland Ice Stream (NEGIS)

Author

Vallelonga, Paul Travis, Christianson, K., Alley, R.B., Anandakrishnan, S., Dahl-Jensen, Dorthe, Gkinis, Vasileios, Holme, Christian Terkelsen, Jacobel, R.w., Karlsson, Nanna Bjørnholt, Keisling, B.A., Kipfstuhl, S., Kjær, Helle Astrid, Kristensen, Magnus Elleskov, Muto, A., Peters, L.E., Popp, Trevor James, Riverman, K.L., Svensson, Anders, Tibuleac, Catalin, Vinther, Bo Møllesøe, Weng, Y, Winstrup, Mai, Vallelonga, Paul Travis, Christianson, K., Alley, R.B., Anandakrishnan, S., Dahl-Jensen, Dorthe, Gkinis, Vasileios, Holme, Christian Terkelsen, Jacobel, R.w., Karlsson, Nanna Bjørnholt, Keisling, B.A., Kipfstuhl, S., Kjær, Helle Astrid, Kristensen, Magnus Elleskov, Muto, A., Peters, L.E., Popp, Trevor James, Riverman, K.L., Svensson, Anders, Tibuleac, Catalin, Vinther, Bo Møllesøe, Weng, Y, and Winstrup, Mai

Published
2014

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