1. Severity of congenital Long QT Syndrome disease onset and risk of depression, anxiety, and mortality: a nationwide study
- Author
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Michael Skov Hansen, R Roerth, Jacob Tfelt-Hansen, Lars Koeber, Jørgen K. Kanters, J Kroell, Christian M. Jespersen, P.E Weeke, Lucas Malta Westergaard, Henning Bundgaard, E L Fosboel, Torp-Pedersen Ct, Henrik Jensen, and Mia N. Christiansen
- Subjects
Congenital long QT syndrome ,Pediatrics ,medicine.medical_specialty ,Disease onset ,business.industry ,medicine ,Anxiety ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Depression (differential diagnoses) - Abstract
Introduction The congenital Long QT Syndrome (cLQTS) is associated with an increased risk of sudden cardiac death (SCD). Thus, cLQTS patients are susceptible to develop depression or anxiety, both of which have been associated with poor outcomes including risk of mortality. Aim We examined if a cLQTS diagnosis and the severity of cLQTS disease onset was associated with an increased risk of depression, anxiety, and all-cause mortality compared with a matched control population. Methods Using Danish nationwide registries and inherited cardiac disease clinics, we identified all patients with known cLQTS (1994–2016) who were ≥18 years at the time of diagnosis. The disease onset for cLQTS was identified as asymptomatic, ventricular tachycardia [VT]/ syncope, aborted SCD [aSCD], or unknown (i.e. no available information). After cLQTS diagnosis, we determined the risk of depression (i.e. depression diagnosis or prescription of antidepressants), anxiety (i.e. anxiety diagnosis or prescription of anxiolytics), and mortality using multivariable Cox proportional hazards regression. Patients were followed for three years. An age and gender matched control population was identified (matching 1:4). Competing risk analysis with death as competing risk was used to generate cumulative incidence plots. Results Overall, 428 cLQTS patients were identified of which 107/428 (25%) developed depression or anxiety after being diagnosed with cLQTS compared with 285/1712 (16.6%) from the control population (p Conclusion The prevalence of depression and anxiety was high among cLQTS patients after diagnosis. Moreover, a graded relationship between severity of disease onset and risk of depression or anxiety was identified. These findings highlight a need for increased awareness following a cLQTS diagnosis in order to reduce the risk of adverse outcomes. Cumulative incidence curve Funding Acknowledgement Type of funding source: Public hospital(s). Main funding source(s): Fund of Rigshospitalet
- Published
- 2020