22 results on '"Christian Hänsel"'
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2. Die Atmosphärologie des Wilhelm August Lampadius (1772-1842)
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Christian Hänsel
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atmosphärenchemie ,geosphären ,bergakademie ,freiberg ,luftdruck ,atmospheric chemistry ,geospheres ,academy of mining ,air pressure ,Meteorology. Climatology ,QC851-999 - Abstract
W. A. Lampadius (1772-1842), bekannt als pionierhafter Chemiker und Hüttenkundler an der Bergakademie Freiberg, befaßte sich intensiv auch mit Atmosphärenchemie und Witterungskunde. Sein monographisches Hauptwerk auf diesem Gebiet, "Systematischer Grundriß der Atmosphärologie", Freiberg 1806, hat bisher kaum gebührende Würdigung erfahren. In knapp, aber präzis formulierten 435 Paragraphen enthält es das zeitgenössische Fachwissen, verbunden mit eigenen Beobachtungen und Ergebnissen des Autors. Mit Wechselbeziehungen zwischen den Geosphären behandelt es frühe Gedanken zur modernen Umweltforschung. Noch vor A. v. Humboldt werden Beziehungen zwischen Klima und Vegetation diskutiert und regionale Klimamerkmale der gesamten Erde beschrieben. Besonders bemerkenswert sind eigene Beobachtungen, mit denen Lampadius (wohl als erster überhaupt?) die Veränderungen von Luftdruck und Witterung beim Durchzug von Zyklonen beschreibt, ohne diese Druckfelder und die Druck-Windfeld-Beziehung zu kennen. Nicht zuletzt verdient das umfangreiche Quellenverzeichnis des Buches mit 580 Zitaten besondere Beachtung.
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- 1997
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3. L-DSMS - A Local Data Stream Management System.
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Christian Hänsel, Hans Jürgen Ohlbach, and Edgar-Philipp Stoffel
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- 2008
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4. Favorable Interfacial Chemomechanics Enables Stable Cycling of High-Li-Content Li–In/Sn Anodes in Sulfide Electrolyte-Based Solid-State Batteries
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Pieremanuele Canepa, David Kiwic, Baltej Singh, Christian Hänsel, and Dipan Kundu
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Battery (electricity) ,Materials science ,General Chemical Engineering ,Intermetallic ,chemistry.chemical_element ,02 engineering and technology ,General Chemistry ,Electrolyte ,Overpotential ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Electrochemistry ,7. Clean energy ,01 natural sciences ,0104 chemical sciences ,Anode ,chemistry ,Chemical engineering ,Materials Chemistry ,Fast ion conductor ,Lithium ,0210 nano-technology - Abstract
Solid-state batteries (SSBs) can offer a paradigm shift in battery safety and energy density. Yet, the promise hinges on the ability to integrate high-performance electrodes with state-of-the-art solid electrolytes. For example, lithium (Li) metal, the most energy-dense anode candidate, suffers from severe interfacial chemomechanical issues that lead to cell failure. Li alloys of In/Sn are attractive alternatives, but their exploration has mostly been limited to the low capacity(low Li content)and In rich Li$_x$In (x$\leq$0.5). Here, the fundamental electro-chemo-mechanical behavior of Li-In and Li-Sn alloys of varied Li stoichiometries is unravelled in sulfide electrolyte based SSBs. The intermetallic electrodes developed through a controlled synthesis and fabrication technique display impressive (electro)chemical stability with Li$_6$PS$_5$Cl as the solid electrolyte and maintain nearly perfect interfacial contact during the electrochemical Li insertion/deinsertion under an optimal stack pressure. Their intriguing variation in the Li migration barrier with composition and its influence on the observed Li cycling overpotential is revealed through combined computational and electrochemical studies. Stable interfacial chemomechanics of the alloys allow long-term dendrite free Li cycling (>1000 h) at relatively high current densities (1 mA cm$^{-2}$) and capacities (1 mAh cm$^{-2}$), as demonstrated for Li$_{13}$In$_3$ and Li$_{17}$Sn$_4$, which are more desirable from a capacity and cost consideration compared to the low Li content analogues. The presented understanding can guide the development of high-capacity Li-In/Sn alloy anodes for SSBs.
- Published
- 2021
5. A Local Data Stream Management System.
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Christian Hänsel, Bernhard Lorenz, and Hans Jürgen Ohlbach
- Published
- 2007
6. Intrinsic and synaptic determinants of receptive field plasticity in Purkinje cells of the mouse cerebellum
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Ting-Feng Lin, Silas E. Busch, and Christian Hansel
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Science - Abstract
Abstract Non-synaptic (intrinsic) plasticity of membrane excitability contributes to aspects of memory formation, but it remains unclear whether it merely facilitates synaptic long-term potentiation or plays a permissive role in determining the impact of synaptic weight increase. We use tactile stimulation and electrical activation of parallel fibers to probe intrinsic and synaptic contributions to receptive field plasticity in awake mice during two-photon calcium imaging of cerebellar Purkinje cells. Repetitive activation of both stimuli induced response potentiation that is impaired in mice with selective deficits in either synaptic or intrinsic plasticity. Spatial analysis of calcium signals demonstrated that intrinsic, but not synaptic plasticity, enhances the spread of dendritic parallel fiber response potentiation. Simultaneous dendrite and axon initial segment recordings confirm these dendritic events affect axonal output. Our findings support the hypothesis that intrinsic plasticity provides an amplification mechanism that exerts a permissive control over the impact of long-term potentiation on neuronal responsiveness.
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- 2024
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7. Stack Pressure Effect in Li3PS4 and Na3PS4 Based Alkali Metal Solid-State Cells: The Dramatic Implication of Interlayer Growth
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Dipan Kundu, Christian Hänsel, and Priyank V. Kumar
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Materials science ,General Chemical Engineering ,Solid-state ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Alkali metal ,01 natural sciences ,0104 chemical sciences ,Anode ,Chemical engineering ,Stack (abstract data type) ,Materials Chemistry ,Fast ion conductor ,0210 nano-technology - Abstract
Despite the rapid growth in the portfolio of attractive Li+/Na+ conducting solid electrolytes (SEs), the corresponding development of solid-state batteries employing high-energy alkali anodes remai...
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- 2020
8. A Single Li-Ion Conductor Based on Cellulose
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Erlantz Lizundia, Dipan Kundu, and Christian Hänsel
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Materials science ,Energy Engineering and Power Technology ,Alkali metal ,Conductor ,Ion ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,Materials Chemistry ,Electrochemistry ,Chemical Engineering (miscellaneous) ,Electrical and Electronic Engineering ,Cellulose ,Realization (systems) ,Deposition (chemistry) ,Electrical conductor - Abstract
Polymeric single-ion conductors, also known as ionomers, are are touted as an enabling solution for stable alkali metal deposition, necessary for the realization of alkali metal batteries. Such ion...
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- 2019
9. Building better all-solid-state batteries with Li-garnet solid electrolytes and metalloid anodes
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Kostiantyn V. Kravchyk, Christian Hänsel, Jan van den Broek, Maksym V. Kovalenko, Semih Afyon, Jennifer L. M. Rupp, and Shutao Wang
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Battery (electricity) ,Materials science ,Renewable Energy, Sustainability and the Environment ,chemistry.chemical_element ,Nanotechnology ,02 engineering and technology ,General Chemistry ,Electrolyte ,021001 nanoscience & nanotechnology ,Electrochemistry ,Energy storage ,Anode ,chemistry ,Fast ion conductor ,General Materials Science ,Lithium ,Metalloid ,0210 nano-technology - Abstract
Journal of Materials Chemistry A, 7 (37), ISSN:2050-7488, ISSN:2050-7496
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- 2019
10. Neural ensembles: role of intrinsic excitability and its plasticity
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Christian Hansel and Rafael Yuste
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engram ,ensemble ,excitability ,intrinsic plasticity ,learning ,memory ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Synaptic connectivity defines groups of neurons that engage in correlated activity during specific functional tasks. These co-active groups of neurons form ensembles, the operational units involved in, for example, sensory perception, motor coordination and memory (then called an engram). Traditionally, ensemble formation has been thought to occur via strengthening of synaptic connections via long-term potentiation (LTP) as a plasticity mechanism. This synaptic theory of memory arises from the learning rules formulated by Hebb and is consistent with many experimental observations. Here, we propose, as an alternative, that the intrinsic excitability of neurons and its plasticity constitute a second, non-synaptic mechanism that could be important for the initial formation of ensembles. Indeed, enhanced neural excitability is widely observed in multiple brain areas subsequent to behavioral learning. In cortical structures and the amygdala, excitability changes are often reported as transient, even though they can last tens of minutes to a few days. Perhaps it is for this reason that they have been traditionally considered as modulatory, merely supporting ensemble formation by facilitating LTP induction, without further involvement in memory function (memory allocation hypothesis). We here suggest−based on two lines of evidence—that beyond modulating LTP allocation, enhanced excitability plays a more fundamental role in learning. First, enhanced excitability constitutes a signature of active ensembles and, due to it, subthreshold synaptic connections become suprathreshold in the absence of synaptic plasticity (iceberg model). Second, enhanced excitability promotes the propagation of dendritic potentials toward the soma and allows for enhanced coupling of EPSP amplitude (LTP) to the spike output (and thus ensemble participation). This permissive gate model describes a need for permanently increased excitability, which seems at odds with its traditional consideration as a short-lived mechanism. We propose that longer modifications in excitability are made possible by a low threshold for intrinsic plasticity induction, suggesting that excitability might be on/off-modulated at short intervals. Consistent with this, in cerebellar Purkinje cells, excitability lasts days to weeks, which shows that in some circuits the duration of the phenomenon is not a limiting factor in the first place. In our model, synaptic plasticity defines the information content received by neurons through the connectivity network that they are embedded in. However, the plasticity of cell-autonomous excitability could dynamically regulate the ensemble participation of individual neurons as well as the overall activity state of an ensemble.
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- 2024
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11. The Stack Pressure Dilemma in Sulfide Electrolyte Based Li Metal Solid‐State Batteries: A Case Study with Li 6 PS 5 Cl Solid Electrolyte
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Dipan Kundu and Christian Hänsel
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chemistry.chemical_classification ,Metal ,Materials science ,Sulfide ,chemistry ,Stack (abstract data type) ,Chemical engineering ,Mechanics of Materials ,Mechanical Engineering ,visual_art ,visual_art.visual_art_medium ,Solid-state ,Electrolyte - Published
- 2021
12. Investigating the all-solid-state batteries based on lithium garnets and a high potential cathode – LiMn1.5Ni0.5O4
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Jennifer L. M. Rupp, Christian Hänsel, and Semih Afyon
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Battery (electricity) ,Materials science ,chemistry.chemical_element ,02 engineering and technology ,Electrolyte ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,7. Clean energy ,Casting ,Cathode ,0104 chemical sciences ,Anode ,law.invention ,Chemical engineering ,chemistry ,law ,Forensic engineering ,Slurry ,General Materials Science ,Lithium ,Chemical stability ,0210 nano-technology - Abstract
All-solid-state Li-ion batteries based on lithium garnets give new prospects for safer battery operations avoiding liquids, and could enable the integration of high energy density electrode materials. Herein, we critically investigate the structural and chemical stability of the high voltage cathode material, LiMn1.5Ni0.5O4, based on the solid lithium garnet electrolyte LLZO (c-Li6.4Ga0.2La3Zr2O12) for all-solid Li-ion batteries. We manufacture battery cells based on nano-grained synthesized LLZO and composite cathodes (LiMn1.5Ni0.5O4/LLZO/C) fabricated via direct slurry casting of the cathode material and additives on sintered LLZO pellets against metallic Li anodes. The galvanostatic tests of such all-solid-state batteries up to 4.9 V at 95 °C reveal the incompatibility of the solid electrolyte and the cathode material under given conditions. Post-mortem analyses of the all-solid-state batteries demonstrate the formation of new inactive phases at the LLZO/LiMn1.5Ni0.5O4 interfacial region through an irreversible reaction starting at ∼3.8 V during charging. The discovered limited chemical stability under the investigated conditions raises the question if LLZO could be a promising solid-electrolyte for future all-solid-state Li-ion batteries especially at higher operation potentials and demanding operation conditions.
- Published
- 2016
13. Investigating the all-solid-state batteries based on lithium garnets and a high potential cathode - LiMn
- Author
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Christian, Hänsel, Semih, Afyon, and Jennifer L M, Rupp
- Abstract
All-solid-state Li-ion batteries based on lithium garnets give new prospects for safer battery operations avoiding liquids, and could enable the integration of high energy density electrode materials. Herein, we critically investigate the structural and chemical stability of the high voltage cathode material, LiMn
- Published
- 2016
14. Overexpression of the autism candidate gene Cyfip1 pathologically enhances olivo-cerebellar signaling in mice
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Silas E. Busch, Dana H. Simmons, Eric Gama, Xiaofei Du, Francesco Longo, Christopher M. Gomez, Eric Klann, and Christian Hansel
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autism ,cerebellum ,Purkinje cell ,CYFIP1 OE transgenic ,electrophysiology ,two-photon Ca2+ imaging ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Cyfip1, the gene encoding cytoplasmic FMR1 interacting protein 1, has been of interest as an autism candidate gene for years. A potential role in autism spectrum disorder (ASD) is suggested by its location on human chromosome 15q11-13, an instable region that gives rise to a variety of copy number variations associated with syndromic autism. In addition, the CYFIP1 protein acts as a binding partner to Fragile X Messenger Ribonucleoprotein (FMRP) in the regulation of translation initiation. Mutation of FMR1, the gene encoding FMRP, causes Fragile X syndrome, another form of syndromic autism. Here, in mice overexpressing CYFIP1, we study response properties of cerebellar Purkinje cells to activity of the climbing fiber input that originates from the inferior olive and provides an instructive signal in sensorimotor input analysis and plasticity. We find that CYFIP1 overexpression results in enhanced localization of the synaptic organizer neurexin 1 (NRXN1) at climbing fiber synaptic input sites on Purkinje cell primary dendrites and concomitant enhanced climbing fiber synaptic transmission (CF-EPSCs) measured using whole-cell patch-clamp recordings from Purkinje cells in vitro. Moreover, using two-photon measurements of GCaMP6f-encoded climbing fiber signals in Purkinje cells of intact mice, we observe enhanced responses to air puff stimuli applied to the whisker field. These findings resemble our previous phenotypic observations in a mouse model for the human 15q11-13 duplication, which does not extend to the Cyfip1 locus. Thus, our study demonstrates that CYFIP1 overexpression shares a limited set of olivo-cerebellar phenotypes as those resulting from an increased number of copies of non-overlapping genes located on chromosome 15q11-13.
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- 2023
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15. Development of Novel Ionomer Electrolytes for Alkali Metal Batteries
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Christian Hänsel and Dipan Kundu
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Single-ion conducting electrolytes are an interesting alternative to liquid binary salt electrolytes, which are currently used in most batteries due to their high ion conductivity. However, the mobility of both cations and anions in these electrolytes results in an ion concentration gradient, and consequent polarisation losses. The ion concentration gradient is especially detrimental for alkali metal batteries. It causes inhomogeneous metal deposition leading to uncontrolled dendrite growth at the alkali metal electrode.1 Thus, it is necessary to eliminate the free movement of anions. One way to achieve that is by covalently tethering the anions to a polymer backbone. So called ionomers have achieved considerable success toward stabilising lithium metal deposition and preventing dendritic structure.2,3 By exchanging the counter ion these ionomers can be used in a wide range of different types of batteries. Here, we report on the synthesis and development of novel ionomers derived from inexpensive and chemically robust polymers. The microporous ionomer membranes infused with liquid achieve cation transference numbers close to unity, high ion conductivity (> 10-5 Scm-1 at room temperature) over wide temperature ranges, and good thermal and mechanical stabilities, see Fig. 1. Stable Na/Li plating stripping performance is achieved using the ionomer membrane. Lin, D. et al., Nanotechnol. 2017, 12, 194–206. Lu, Y. et al., Adv. Energy Mater. 2015, 5, 1402073. Oh, H. et al., Mater., 2016, 28, 188-196. Caption Fig.: Fig 1: (a) Photograph and SEM image of the microporous ionomer membrane. (b) Arrhenius plot of the Na+ ion conductivity of the microporous ionomer membrane infused with EC/DEC (vol. 1:1). Figure 1
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- 2018
16. The atmospherology of Wilhelm August Lampadius (1772-1842)
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Christian Hänsel
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Atmospheric Science ,media_common.quotation_subject ,Art ,Humanities ,media_common - Published
- 1997
17. Zur Dynamik der Antizyklonen der mittleren Breiten
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Christian Hänsel and Christian Hänsel
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- 1961
18. SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces.
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Giorgio Grasselli, Henk-Jan Boele, Heather K Titley, Nora Bradford, Lisa van Beers, Lindsey Jay, Gerco C Beekhof, Silas E Busch, Chris I De Zeeuw, Martijn Schonewille, and Christian Hansel
- Subjects
Biology (General) ,QH301-705.5 - Abstract
Neurons store information by changing synaptic input weights. In addition, they can adjust their membrane excitability to alter spike output. Here, we demonstrate a role of such "intrinsic plasticity" in behavioral learning in a mouse model that allows us to detect specific consequences of absent excitability modulation. Mice with a Purkinje-cell-specific knockout (KO) of the calcium-activated K+ channel SK2 (L7-SK2) show intact vestibulo-ocular reflex (VOR) gain adaptation but impaired eyeblink conditioning (EBC), which relies on the ability to establish associations between stimuli, with the eyelid closure itself depending on a transient suppression of spike firing. In these mice, the intrinsic plasticity of Purkinje cells is prevented without affecting long-term depression or potentiation at their parallel fiber (PF) input. In contrast to the typical spike pattern of EBC-supporting zebrin-negative Purkinje cells, L7-SK2 neurons show reduced background spiking but enhanced excitability. Thus, SK2 plasticity and excitability modulation are essential for specific forms of motor learning.
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- 2020
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19. Synaptic Potential and Plasticity of an SK2 Channel Gate Regulate Spike Burst Activity in Cerebellar Purkinje Cells
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Gen Ohtsuki and Christian Hansel
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Science - Abstract
Summary: Neurons store information and participate in memory engrams as a result of experience-dependent changes in synaptic weights and in membrane excitability. Here, we examine excitatory postsynaptic potential (EPSP) amplitude and neuronal excitability in relation to these two mechanisms of plasticity. We analyze somato-dendritic double-patch recordings from cerebellar Purkinje cells while inducing intrinsic, SK2 channel-dependent plasticity or blocking SK channels with bath application of apamin. Both manipulations increase the build-up of EPSP amplitudes during an EPSP train and enhance the number of EPSP-evoked spikes, yielding insights into the mechanistic contribution of EPSP amplitude to single spikes and spike bursts. EPSP amplitude has an impact on whether spikes are fired or not, but direct measures of excitability (spike threshold/AHP) are better predictors of whether individual spikes or spike bursts are fired. Our findings show that Purkinje cell spiking is synaptically driven but that burst firing is gated by SK2 channel modulation and plasticity. : Neuroscience; Cellular Neuroscience; Specialized Functions of Cells Subject Areas: Neuroscience, Cellular Neuroscience, Specialized Functions of Cells
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- 2018
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20. Activity-Dependent Plasticity of Spike Pauses in Cerebellar Purkinje Cells
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Giorgio Grasselli, Qionger He, Vivian Wan, John P. Adelman, Gen Ohtsuki, and Christian Hansel
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Biology (General) ,QH301-705.5 - Abstract
The plasticity of intrinsic excitability has been described in several types of neurons, but the significance of non-synaptic mechanisms in brain plasticity and learning remains elusive. Cerebellar Purkinje cells are inhibitory neurons that spontaneously fire action potentials at high frequencies and regulate activity in their target cells in the cerebellar nuclei by generating a characteristic spike burst-pause sequence upon synaptic activation. Using patch-clamp recordings from mouse Purkinje cells, we find that depolarization-triggered intrinsic plasticity enhances spike firing and shortens the duration of spike pauses. Pause plasticity is absent from mice lacking SK2-type potassium channels (SK2−/− mice) and in occlusion experiments using the SK channel blocker apamin, while apamin wash-in mimics pause reduction. Our findings demonstrate that spike pauses can be regulated through an activity-dependent, exclusively non-synaptic, SK2 channel-dependent mechanism and suggest that pause plasticity—by altering the Purkinje cell output—may be crucial to cerebellar information storage and learning.
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- 2016
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21. Cerebellar associative sensory learning defects in five mouse autism models
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Alexander D Kloth, Aleksandra Badura, Amy Li, Adriana Cherskov, Sara G Connolly, Andrea Giovannucci, M Ali Bangash, Giorgio Grasselli, Olga Peñagarikano, Claire Piochon, Peter T Tsai, Daniel H Geschwind, Christian Hansel, Mustafa Sahin, Toru Takumi, Paul F Worley, and Samuel S-H Wang
- Subjects
autism spectrum disorder ,associative learning ,cerebellum ,Medicine ,Science ,Biology (General) ,QH301-705.5 - Abstract
Sensory integration difficulties have been reported in autism, but their underlying brain-circuit mechanisms are underexplored. Using five autism-related mouse models, Shank3+/ΔC, Mecp2R308/Y, Cntnap2−/−, L7-Tsc1 (L7/Pcp2Cre::Tsc1flox/+), and patDp(15q11-13)/+, we report specific perturbations in delay eyeblink conditioning, a form of associative sensory learning requiring cerebellar plasticity. By distinguishing perturbations in the probability and characteristics of learned responses, we found that probability was reduced in Cntnap2−/−, patDp(15q11-13)/+, and L7/Pcp2Cre::Tsc1flox/+, which are associated with Purkinje-cell/deep-nuclear gene expression, along with Shank3+/ΔC. Amplitudes were smaller in L7/Pcp2Cre::Tsc1flox/+ as well as Shank3+/ΔC and Mecp2R308/Y, which are associated with granule cell pathway expression. Shank3+/ΔC and Mecp2R308/Y also showed aberrant response timing and reduced Purkinje-cell dendritic spine density. Overall, our observations are potentially accounted for by defects in instructed learning in the olivocerebellar loop and response representation in the granule cell pathway. Our findings indicate that defects in associative temporal binding of sensory events are widespread in autism mouse models.
- Published
- 2015
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22. Climbing fiber signaling and cerebellar gain control
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Gen Ohtsuki, Claire Piochon, and Christian Hansel
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Calcium ,Cerebellum ,Long-Term Potentiation ,Purkinje cell ,Long-term depression ,climbing fiber ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
The physiology of climbing fiber signals in cerebellar Purkinje cells has been studied since the early days of electrophysiology. Both the climbing fiber-evoked complex spike and the role of climbing fiber activity in the induction of long-term depression (LTD) at parallel fiber-Purkinje cell synapses have become hallmark features of cerebellar physiology. However, the key role of climbing fiber signaling in cerebellar motor learning has been challenged by recent reports of forms of synaptic and non-synaptic plasticity in the cerebellar cortex that do not involve climbing fiber activity, but might well play a role in cerebellar learning. Moreover, cerebellar LTD does not seem to strictly require climbing fiber activity. These observations make it necessary to re-evaluate the role of climbing fiber signaling in cerebellar function. Here, we argue that climbing fiber signaling is about adjusting relative probabilities for the induction of LTD and long-term potentiation (LTP) at parallel fiber synapses. Complex spike-associated, dendritic calcium transients control postsynaptic LTD and LTP induction. High calcium transients, provided by complex spike activity, do not only favor postsynaptic LTD induction, but simultaneously trigger retrograde cannabinoid signaling, which blocks the induction of presynaptic LTP. Plasticity of the climbing fiber input itself provides additional means to fine-tune complex spike associated calcium signaling and thus to adjust the gain of heterosynaptic climbing fiber control. In addition to dendritic calcium transients, climbing fiber activity leads to the release of the neuropeptide corticotropin-releasing factor (CRF), which facilitates LTD induction at both parallel fiber and climbing fiber synapses.
- Published
- 2009
- Full Text
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