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5. Periportale Steatose bei Mäusen beeinflusst verschiedene Parameter des perizentralen Arzneimittelstoffwechsels

Author

Albadry, M, additional, Höpfl, S, additional, Ehteshamzad, N, additional, König, M, additional, Böttcher, M, additional, Neumann, J, additional, Lupp, A, additional, Dirsch, O, additional, Radde, N, additional, Christ, B, additional, Christ, M, additional, Schwen, L, additional, Laue, H, additional, Klopfleisch, R, additional, and Dahmen, U, additional

Published
2023
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10. Design and implementation of a global site assessment survey among HIV clinics participating in the International epidemiology Databases to Evaluate AIDS (IeDEA) research consortium

Author

Parcesepe A., William Wester C., Hossmann S., Freeman E., Kimmel A., Lancaster K.E., Brazier E., Duda S.N., Maruri F., Ballif M., Musick B., Christ B., Golub J.E., Enane L.A., Humphrey J., Freeman A., and Nash D.

Abstract

Introduction Timely descriptions of HIV service characteristics and their evolution over time across diverse settings are important for monitoring the scale-up of evidence-based program strategies, understanding the implementation landscape, and examining service delivery factors that influence HIV care outcomes. Methods The International epidemiology Databases to Evaluate AIDS (IeDEA) consortium undertakes periodic cross-sectional surveys on service availability and care at participating HIV treatment sites to characterize trends and inform the scientific agenda for HIV care and implementation science communities. IeDEA’s 2020 general site assessment survey was developed through a consultative, 18-month process that engaged diverse researchers in identifying content from previous surveys that should be retained for longitudinal analyses and in developing expanded and new content to address gaps in the literature. An iterative review process was undertaken to standardize the format of new survey questions and align them with best practices in survey design and measurement and lessons learned through prior IeDEA site assessment surveys. Results The survey questionnaire developed through this process included eight content domains covered in prior surveys (patient population, staffing and community linkages, HIV testing and diagnosis, new patient care, treatment monitoring and retention, routine HIV care and screening, pharmacy, record-keeping and patient tracing), along with expanded content related to antiretroviral therapy (differentiated service delivery and roll-out of dolutegravir-based regimens); mental health and substance use disorders; care for pregnant/postpartum women and HIV-exposed infants; tuberculosis preventive therapy; and pediatric/adolescent tuberculosis care; and new content related to Kaposi’s sarcoma diagnostics, the impact of COVID-19 on service delivery, and structural barriers to HIV care. The survey was distributed to 238 HIV treatment sites in late 2020, with a 95% response rate. Conclusion IeDEA’s approach for site survey development has broad relevance for HIV research networks and other priority health conditions.

Published
2023
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18. Entwicklung der Rumpfwand

Author

Christ, B., Hinrichsen, Klaus V., editor, Beier, Henning M., editor, Breucker, Haide, editor, Christ, Bodo, editor, Duncker, Hans-Rainer, editor, Dvořák, Milan, editor, von Gaudecker, Brita, editor, von Dorsche, Herwig Hahn, editor, Holstein, Adolf Friedrich, editor, Jacob, Heinz Jürgen, editor, Jacob, Monika, editor, Jorch, Gerhard, editor, Kaufmann, Peter, editor, Kostović, Ivica, editor, Prindull, Gregor, editor, Seidl, Wolfgang, editor, Steding, Gerd, editor, Tesařík, Jan, editor, and Wartenberg, Hubert, editor

Published
1990
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19. Entwicklung der Haut

Author

Christ, B., Hinrichsen, Klaus V., editor, Beier, Henning M., editor, Breucker, Haide, editor, Christ, Bodo, editor, Duncker, Hans-Rainer, editor, Dvořák, Milan, editor, von Gaudecker, Brita, editor, von Dorsche, Herwig Hahn, editor, Holstein, Adolf Friedrich, editor, Jacob, Heinz Jürgen, editor, Jacob, Monika, editor, Jorch, Gerhard, editor, Kaufmann, Peter, editor, Kostović, Ivica, editor, Prindull, Gregor, editor, Seidl, Wolfgang, editor, Steding, Gerd, editor, Tesařík, Jan, editor, and Wartenberg, Hubert, editor

Published
1990
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20. Entwicklung der Extremitäten

Author

Christ, B., Hinrichsen, Klaus V., editor, Beier, Henning M., editor, Breucker, Haide, editor, Christ, Bodo, editor, Duncker, Hans-Rainer, editor, Dvořák, Milan, editor, von Gaudecker, Brita, editor, von Dorsche, Herwig Hahn, editor, Holstein, Adolf Friedrich, editor, Jacob, Heinz Jürgen, editor, Jacob, Monika, editor, Jorch, Gerhard, editor, Kaufmann, Peter, editor, Kostović, Ivica, editor, Prindull, Gregor, editor, Seidl, Wolfgang, editor, Steding, Gerd, editor, Tesařík, Jan, editor, and Wartenberg, Hubert, editor

Published
1990
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21. Methoden

Author

Hinrichsen, K. V., Christ, B., Hinrichsen, Klaus V., editor, Beier, Henning M., editor, Breucker, Haide, editor, Christ, Bodo, editor, Duncker, Hans-Rainer, editor, Dvořák, Milan, editor, von Gaudecker, Brita, editor, von Dorsche, Herwig Hahn, editor, Holstein, Adolf Friedrich, editor, Jacob, Heinz Jürgen, editor, Jacob, Monika, editor, Jorch, Gerhard, editor, Kaufmann, Peter, editor, Kostović, Ivica, editor, Prindull, Gregor, editor, Seidl, Wolfgang, editor, Steding, Gerd, editor, Tesařík, Jan, editor, and Wartenberg, Hubert, editor

Published
1990
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22. Cardio-vaskuläres System

Author

Steding, G., Seidl, W., Christ, B., Hinrichsen, Klaus V., editor, Beier, Henning M., editor, Breucker, Haide, editor, Christ, Bodo, editor, Duncker, Hans-Rainer, editor, Dvořák, Milan, editor, von Gaudecker, Brita, editor, von Dorsche, Herwig Hahn, editor, Holstein, Adolf Friedrich, editor, Jacob, Heinz Jürgen, editor, Jacob, Monika, editor, Jorch, Gerhard, editor, Kaufmann, Peter, editor, Kostović, Ivica, editor, Prindull, Gregor, editor, Seidl, Wolfgang, editor, Steding, Gerd, editor, Tesařík, Jan, editor, and Wartenberg, Hubert, editor

Published
1990
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27. Abstracts of papers presented at the 81st annual meeting of The Potato Association of America Charlottetown, P.E.I., Canada August 3 – 7, 1997

Author

Ali-Khan S. T., Hetner, C., Ladislav, L., Currie, V., Arsenault Walter J., Aziz A. Naseer, Seabrook, Janet E. A., Tai, George C. C., Bamberg J. B., del Rio, Alfonso H., Martin, Max, Bamberg J. B., Ormrod, D. J., Fry, W. E., Barrett K. B., Nolte, P., Jones, W. B., Bateman, M. A., Bertram, M. C., Nolte, L. L., Bertram Melissa C., Ojala, John, Barrall, Geoffrey A., Blankemeyer James T., McWilliams, Misty L., Friedman, Mendel, Boiteau Gilles, Boluarte Tatiana, Veilleux, Richard E., Brown C. R., Schuck-Ennis, B., Yang, C. P., Mojtahedi, H., Santo, G. S., Cambouris Athyna N., Nolin, Michel C., Simard, Régis R., Cani Eduard, Ashkenazi, Varda, Hillel, Jossi, Veilleux, Richard E., Cappaert M. R., Powelson, M. L., Inglis, D. I., Cappaert M. R., Powelson, M. L., Chen Yu-Kuang, Bamberg, John B., Palta, Jiwan P., Christ B. J., Haynes, K. G., Coltman Robert R., German, Thomas L., Corsini Dennis, Kleinkopf, Gale, Brandt, Tina, Outright Rebecca, Veilleux, Richard E., Dan H., Stankiewicz, A., Ali-Khan, S. T., Robb, J., Davidson Robert D., Douches D. S., Kirk, W. W., Bamberg, J. B., Edwards Linnell M., Emery Suzanne M., Halseth, Donald E., Ewing Elmer E., Simko, Ivan, Davies, Peter J., Fernando Sydney, McMorran, Jeffrey, Mosley, Alvin, Clough, George, Finnan David, Allen, Eric, Fitzgerald Caragh B., Porter, Gregory A., Erich, M. Susan, Goth R. W., Haynes, K. G., Grafius E. J., Mota-Sanchez, D., Bishop, B. A., Whalon, M. E., Groza Horia, Bowen, Bryan, Jiang, Jiming, Groza Horia, Coltman, Robert, Gunter Christopher C., Palta, Jiwan P., Gunter Christopher C., Palta, Jiwan P., Hamernik A. J., Hanneman, R. E., Hamm Philip B., Ingham, Russell E., Jaeger, Joy R., Hanneman R. E., Haynes K. G., Lambert, D. H., Christ, B. J., Weingartner, D. P., Douches, D. S., Backlund, J. E., Secor, G., Fry, W., Stevenson, W., Helgeson J. P., Haberlach, G. T., McGrath, J. M., Raasch, J. A., Naess, S. K., Wielgus, S. M., Hernández A., Lozoya-Saldaña, H., Zavala, T., Honess Brian L., Tai, George C. C., Honeycutt C. Wayne, Hughes Becky R., Keith, Candy N. F., Inglis D. A., Gundersen, B., Powelson, M. L., Cappaert, M. R., Inglis D., Gundersen, B., Thornton, R., Jansky Shelley, Rouse, Doug, Johnson Alexander, Piovano, Suzanne, Ravichandran, Vidya, Teparkum, Sirasak, Chani, Eduard, Veilleux, Richard E., Jones W. B., Hempstead, D. W., Scott, J. B., Kalt Willy, Prange, Robert, Daniels-Lake, Barbara, Walsh, John, Dean, Paul, Coffin, Robert, Page, Robyne, Kawchuk L. M., DeJong, H., Burns, V. J., Kimpinski J., Platt, H. W., Kirk William, Niemira, Brendan A., Kitchen, Brian, Stein, Jeffery, Hammerschmidt, Raymond, Kowalski Stanley P., Domek, John M., Perez, Frances G., Sanford, Lind L., Deahl, Kenneth L., Kowalski Stanley P., Yencho, G. Craig, Kobayashi, Ruth S., Perez, Frances G., Sinden, Stephen L., Deahl, Kenneth L., Laird David W., Bassi, Albert B., Tally, Allison, Lambert Dave, Currier, Ann, Olanya, Modesto, Li W., Douches, D. S., Pett, W., Coombs, J., Zarka, K., Grafius, E., Loria Rosemary, Fry, Barbara A., Bukhalid, Raghida A., Grace, Elizabeth A., Langille Alan R., Lan, Yu, Reeves, A. F., Love Stephen L., Werner, Bruce K., Pavek, Joseph J., Lozoya-Saldaña H., Hernãndez, A., Lozova-Saldaña H., Hern↭dez, A., Flores, R., Bamberg, J., Ludy R. L., Powelson, M. L., Lulai Edward C., Klinge, Manrique, Kurt Stephen L. Lovev, Brown, Jack, Marco Medina, Platt, H. W., Peters, R. D., McBeath Jenifer Huang, Miller J., Creighton Douglas C., Scheuring Jeannine P. Millerv, Fernandez, George C. J., Mills Dallice, Russell, Brian W., Mozafari J., Wolyn, D. J., Ali-Khan, S. T., Mpofu S. I., Hall, R., Mundy C., Creamer, N. G., Crozier, C. R., Morse, R. D., Newberry George, Thornton, Robert, Niemira Brendan A., Kirk, William, Douches, David, Hammerschmidt, Raymond, Nolte P., Thornton, M. K., Love, S. L., Berger, P. H., Whitworth, J. L., Davidson, R., Novy Richard, Longtine, Craig, Etuberosum, Solanum, Olivier Claudia, Mizubuti, Eduardo S. G., Halseth, Donald E., Loria, Rosemary, Olsen Nora L., Thornton, Robert E., Parks R. L., Powelson, M. L., Cappaert, M. R., Johnson, K. B., Pavek Joseph J., Corsini, Dennis L., Pavuluri Sridevi, Freeman, T. P., Baer, D., Gudmestad, N. C., Pelletier Yvan, Peralta Iris E., Ballard, Harvey, Spooner, David M., Peters R. D., Platt, H. W. (Bud), Hall, Robert, Driscoll, A., MacPhail, A., Jenkins, S., Connors, E., Medina, M., MacLean, V., Philip Maxwell, Platt, H. W., Nazar, R., Robb, J., MacLean, V., Pineda Omaira, Plaisted, Robert L., Tanksley, Steven D., Pineda Omaira, Plaisted, Robert L., Tanksley, Steven D., Platt H. W., Medina, M., Perley, S., Walsh, J., Porter Gregory A., Sisson, Jonathan A., Porter Gregory A., Sisson, Jonathan A., Power R. J., Hamlen, R. A., Gimenez, R. M., Iruegas, R., Prange Robert, Kalt, Willy, Daniels-Lake, Barbara, Liew, Chiam, Walsh, John, Dean, Paul, Coffin, Robert, Page, Robyne, Ramon M., Serquen, Felix C., Hanneman, R. E., Riggle Bruce, Schafer, Ron, del Rio Alfonso H., Bamberg, J. B., Romain R., Lambert, R., Michaud, R., Lapointe, C., Ronning Catherine M., Sanford, Lind L., Stommel, John R., Perez, Frances G., Deahl, Kenneth L., Sanderson J. Brian, Carter, M. R., Johnston, H. W., Holmstrom, D. A., Sanford L. L., Kowalski, S., Deahl, K. L., Ronning, C., Schisler D. A., Kleinkopf, G., Slininger, P. J., Bothast, R. J., Ostrowski, R. C., Seabrook Janet E. A., Douglass, L. Katheryn, Sedegui Mohamed, R. B., Carroll A. L. Morehart, Whittington, D. P., Mullroony, R. P., Serquen Felix C., Hanneman, Robert E., Simard Régis R., Cambouris, Athyna, Lafond, Jean, Tyouss, A., Singh Mathuresh, Singh, Rudra P., Singh Rudra P., Slininger P. J., Schisler, D. A., Burkhead, K. D., Ostrowski, R. C., Bothast, R. J., Song Junqi, Jiang, Jiming, Souza-Dias Jose A., de Caram P. Russo, Betti, J. A., Miller, L., Slack, S. A., Souza-Dias Jose A., de Caram, Tristao, J. F., Sowokinos Joseph R., Stalham Mark, Rosenfeld, Anton, Stewart Jeff, Sturz Antony V., Matheson, Brian G., Teparkum Sirasak, Veilleux, Richard E., Thompson-Johns Asunta, Davidson, Robert D., Timm George H., Thornton, Robert E., Van Hest Peter, van der Merwe, J. J., Vayda Michael E., Morelli, James K., Englehart, Kathryn M., Vega Sandra E., Bamberg, John B., Palta, Jiwan P., Walsh John, Peterson, R. Larry, Melville, Lewis, Wang L., Pritchard, M. K., Wang L., Pritchard, M. K., Westedt A., Douches, D. S., Grafius, E., Westermann D. T., Davis, J. R., Everson, D. O., Work Richard W., Work, T. M., Bushway, A. A., Work Therese M., Reeves, Alvin A., Yu Wan-Chin, Joyce, Peter J., Cameron, Douglas C., McCown, Brent H., and Veilleux, Richard E.

Published
1997
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28. Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo

Author

Aurich, H., Sgodda, M., Kaltwaber, P., Vetter, M., Weise, A., Liehr, T., Brulport, M., Hengstler, J.G., Dollinger, M.M., Fleig, W.E., and Christ, B.

Subjects
Liver cells -- Physiological aspects, Liver cells -- Comparative analysis, Stem cells -- Comparative analysis, Adipose tissues -- Physiological aspects, Adipose tissues -- Comparative analysis, Liver -- Transplantation, Liver -- Patient outcomes, Liver -- Research, Health
Published
2009

29. Hepatic progenitor cells form adult human livers for cell transplantation

Author

Weiss, T.S., Lichtenauer, M., Kirchner, S., Stock, P., Aurich, H., Christ, B., Brockhoff, G., Kunz-Schughart, L.A., Jauch, K.-W., Schlitt, H.-J., and Thasler, W.E.

Subjects
Liver cells -- Physiological aspects, Liver cells -- Analysis, Lymphocytes -- Physiological aspects, Lymphocytes -- Research, Liver -- Transplantation, Liver -- Patient outcomes, Liver -- Physiological aspects, Liver -- Research, Health
Published
2008

40. Mitochondrial transfer by human mesenchymal stromal cells ameliorates hepatocyte lipid load in a mouse model of NASH

Author

Hsu, M.-J., Karkossa, Isabel, Schäfer, I., Christ, M., Kühne, H., Schubert, Kristin, Rolle-Kampczyk, Ulrike, Kalkhof, Stefan, Nickel, S., Seibel, P., von Bergen, Martin, Christ, B., Hsu, M.-J., Karkossa, Isabel, Schäfer, I., Christ, M., Kühne, H., Schubert, Kristin, Rolle-Kampczyk, Ulrike, Kalkhof, Stefan, Nickel, S., Seibel, P., von Bergen, Martin, and Christ, B.

Abstract

Mesenchymal stromal cell (MSC) transplantation ameliorated hepatic lipid load; tissue inflammation; and fibrosis in rodent animal models of non-alcoholic steatohepatitis (NASH) by as yet largely unknown mechanism(s). In a mouse model of NASH; we transplanted bone marrow-derived MSCs into the livers; which were analyzed one week thereafter. Combined metabolomic and proteomic data were applied to weighted gene correlation network analysis (WGCNA) and subsequent identification of key drivers. Livers were analyzed histologically and biochemically. The mechanisms of MSC action on hepatocyte lipid accumulation were studied in co-cultures of hepatocytes and MSCs by quantitative image analysis and immunocytochemistry. WGCNA and key driver analysis revealed that NASH caused the impairment of central carbon; amino acid; and lipid metabolism associated with mitochondrial and peroxisomal dysfunction; which was reversed by MSC treatment. MSC improved hepatic lipid metabolism and tissue homeostasis. In co-cultures of hepatocytes and MSCs; the decrease of lipid load was associated with the transfer of mitochondria from the MSCs to the hepatocytes via tunneling nanotubes (TNTs). Hence; MSCs may ameliorate lipid load and tissue perturbance by the donation of mitochondria to the hepatocytes. Thereby; they may provide oxidative capacity for lipid breakdown and thus promote recovery from NASH-induced metabolic impairment and tissue injury.

Published
2020

47. The role of Emx2 during scapula formation

Author

Prols, F., Ehehalt, F., Rodriguez-Niedenfuhr, M., He, L., Huang, R., and Christ, B.

Subjects
Scapula -- Research, Biological sciences
Abstract

The scapula is subdivided into head, collum, and blade. Due to the expression pattern of Emx2 and the absence of the scapula blade in Emx2 knockout mice, it has been suggested that Emx2 is involved in the formation of the scapula. Micromanipulation experiments revealed that ectoderm ablation over the somites does not affect Emx2 expression but inhibits the formation of the scapula blade indicating that Emx2 is not sufficient to induce scapula blade formation. Furthermore, we show that the formation of the scapula head is dependent, scapula blade formation independent of FGFR-1-mediated signaling. Overexpression of Emx2 does not influence scapula blade formation but leads to the development of an additional posterior digit in the anterior border of the limb. Taken together, the data presented implicate that Emx2 expression is necessary but not sufficient for the development of the scapula blade. It is not a marker for scapula development but rather provides positional information along the proximodistal and anterior-posterior limb axes, whereas the specificity of the developing skeletal elements is determined by the concerted interaction of Emx2 with other factors. Keywords: Scapula development: Chick; Emx2; FGF; Retinoic acid

Published
2004

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