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1. Auto-antibodies against type I IFNs in patients with life-threatening COVID-19

2. Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

3. Autoantibodies against type I IFNs in patients with life-threatening COVID-19

4. Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency

5. Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells

6. Selective predisposition to bacterial infections in IRAK-4-deficient children:: IRAK-4-dependent TLRs are otherwise redundant in protective immunity

9. Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells

10. Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

11. Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling.

12. Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis.

13. Impaired IL-23-dependent induction of IFN-γ underlies mycobacterial disease in patients with inherited TYK2 deficiency.

14. Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin.

15. Biochemically deleterious human NFKB1 variants underlie an autosomal dominant form of common variable immunodeficiency.

16. Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child.

17. Human STAT3 variants underlie autosomal dominant hyper-IgE syndrome by negative dominance.

18. Inherited deficiency of stress granule ZNFX1 in patients with monocytosis and mycobacterial disease.

19. Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine.

20. Systemic Type I IFN Inflammation in Human ISG15 Deficiency Leads to Necrotizing Skin Lesions.

21. Genome-wide association study of Buruli ulcer in rural Benin highlights role of two LncRNAs and the autophagy pathway.

22. Chronic mucocutaneous candidiasis and connective tissue disorder in humans with impaired JNK1-dependent responses to IL-17A/F and TGF-β.

23. A deep intronic splice mutation of STAT3 underlies hyper IgE syndrome by negative dominance.

24. Rescue of recurrent deep intronic mutation underlying cell type-dependent quantitative NEMO deficiency.

26. IRAK4 Deficiency in a Patient with Recurrent Pneumococcal Infections: Case Report and Review of the Literature.

27. Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity.

28. Inherited human IRAK-1 deficiency selectively impairs TLR signaling in fibroblasts.

29. Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations.

30. Proinflammatory cytokine response toward fungi but not bacteria in chronic granulomatous disease.

31. Heterozygous Mutations in MAP3K7, Encoding TGF-β-Activated Kinase 1, Cause Cardiospondylocarpofacial Syndrome.

32. Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia.

33. Invasive pneumococcal disease in children can reveal a primary immunodeficiency.

34. IgM+IgD+CD27+ B cells are markedly reduced in IRAK-4-, MyD88-, and TIRAP- but not UNC-93B-deficient patients.

35. Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency.

36. Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis.

37. Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis.

38. New mechanism of X-linked anhidrotic ectodermal dysplasia with immunodeficiency: impairment of ubiquitin binding despite normal folding of NEMO protein.

39. Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity.

40. Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I.

41. Very late-onset group B Streptococcus meningitis, sepsis, and systemic shigellosis due to interleukin-1 receptor-associated kinase-4 deficiency.

42. Pyogenic bacterial infections in humans with MyD88 deficiency.

43. Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells.

44. Recurrent staphylococcal cellulitis and subcutaneous abscesses in a child with autoantibodies against IL-6.

45. Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity.

46. A fast procedure for the detection of defects in Toll-like receptor signaling.

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