Search

A majority of previously reported methods suffer from insufficient yields as well as more complicated experimental procedures, a smaller amount of isolated yields involving time-consuming and tiresome work-up with the use of metal catalyst and restricted scope of substrates. To overcome these issues, an environmentally benign, ionic liquid endorsed multi-component protocol to N -substituted azepines has been exploited by means of coupling aromatic amines, dimethyl/diethyl acetylene dicarboxylate, 2,5-dimethoxytetrahydrofuran using 1,3-Di- n -butylimidazolium tribromide [BBim]Br 3 . The catalyst can be recycled and reused for subsequent reactions. The reactivated ionic liquid could be further reused twice as an accelerator All the synthesized compounds were further screened for their antimicrobial properties against three gram positive, four gram negative, and five fungal strains with chloromycin, norflaxacin, and fluconazole as reference drugs. Most of the tested compounds presented significant potency, especially, compound 4e displayed significant antibacterial activity (MIC = 1–16 μg/mL) whereas compound 4k showed momentous antifungal efficacy (MIC = 2–32 μg/mL). In addition binding behavior of compound 4e was investigated by binding study between calf thymus DNA and compound 4e by UV–Visible absorption spectroscopy and further research about HSA interactions were carried out. The observed wavelength showed a constancy thus revealing the occurrence of non-covalent π-π stacking interactions of compound 4e and HSA. [ABSTRACT FROM AUTHOR]

[Ce(L-Pro)2]2 (Oxa) was used as a recyclable heterogeneous catalyst under mild conditions for the preparation of 2-aryl-2,3-dihydroquinazolin-4(1H)-one derivatives. The one-pot protocol proceeds in ethanol using anthranilamide with several aldehydes at 50-55 °C. The catalyst can be recycled and reused three cycles without significant loss of catalytic activity. [ABSTRACT FROM AUTHOR]

We developed a novel and highly efficient protocol for the synthesis of important pyrazole derivatives by using some 1,3-dicarbonyl compounds and phenyl hydrazines via a one-pot protocol. As a recyclable heterogeneous catalyst, we used [Ce(l-Pro)2]2 (Oxa). In addition, the catalyst is recyclable, the proline is economically viable and readily available in both enantiomeric forms and the catalyst is insoluble in almost all solvents and may be easily filtered off from the reaction medium. Moreover, this new synthetic protocol features high conversion, short reaction times, a straightforward procedure and cleaner reaction profiles. [ABSTRACT FROM AUTHOR]

The article presents chemical equation for the article "β-Cyclodextrin as a Recyclable Catalyst: Aqueous Phase One-Pot Four-Component Synthesis of Polyfunctionalized Pyrroles" by K. Konkala and others, published in the journal "RSC Advances" in 2016.

The title compounds are synthesized in water under neutral conditions by the reaction of aromatic aldehydes with 2-amino thiophenol (I) or o-phenylenediamine (IV) mediated by β-cyclodextrin in high yields. [ABSTRACT FROM AUTHOR]