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165 results on '"Chowdhury NR"'

1. Search for Spatial Correlations of Neutrinos with Ultra-high-energy Cosmic Rays

Author: collaboration, The ANTARES, Albert, A, Alves, S, André, M, Anghinolfi, M, A., M, Ardid, S, Aubert, J-J, Aublin, J, Baret, B, Basa, S, Belhorma, B, Bendahman, M, Bertin, V, Biagi, S, Bissinger, M, Boumaaza, J, Bouta, M, Bouwhuis, MC, Brânzaş, H, Bruijn, R, Brunner, J, Busto, J, Caiffi, B, Calvo, D, Capone, A, Caramete, L, Carr, J, Carretero, V, Celli, S, Chabab, M, Chau, TN, Moursli, R Cherkaoui El, Chiarusi, T, Circella, M, Coleiro, A, Coniglione, R, Coyle, P, Creusot, A, Díaz, AF, Distefano, C, Di Palma, I, Domi, A, Donzaud, C, Dornic, D, Drouhin, D, Eberl, T, van Eeden, T, van Eijk, D, Khayati, N El, Enzenhöfer, A, Fermani, P, Ferrara, G, Filippini, F, Fusco, L, Gatelet, Y, Gay, P, Glotin, H, Gozzini, R, Ruiz, R Gracia, Graf, K, Guidi, C, Hallmann, S, van Haren, H, Heijboer, AJ, Hello, Y, Hernández-Rey, JJ, Hössl, J, Hofestädt, J, Huang, F, Illuminati, G, James, CW, Jisse-Jung, B, De Jong, M, de Jong, P, Kadler, M, Kalekin, O, Katz, U, Khan-Chowdhury, NR, Kouchner, A, Kreykenbohm, I, Kulikovskiy, V, Lahmann, R, Le Breton, R, LeStum, S, Lefèvre, D, Leonora, E, Levi, G, Lopez-Coto, D, Loucatos, S, Maderer, L, Manczak, J, Marcelin, M, Margiotta, A, Marinelli, A, Martínez-Mora, JA, Martino, B, Melis, K, Migliozzi, P, and Moussa, A
Subjects: Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Neutrino astronomy, High energy astrophysics, Ultra-high-energy cosmic radiation, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Physical Chemistry (incl. Structural), Astronomy & Astrophysics, Astronomical sciences, Particle and high energy physics, Space sciences
Abstract: For several decades, the origin of ultra-high-energy cosmic rays (UHECRs) has been an unsolved question of high-energy astrophysics. One approach for solving this puzzle is to correlate UHECRs with high-energy neutrinos, since neutrinos are a direct probe of hadronic interactions of cosmic rays and are not deflected by magnetic fields. In this paper, we present three different approaches for correlating the arrival directions of neutrinos with the arrival directions of UHECRs. The neutrino data are provided by the IceCube Neutrino Observatory and ANTARES, while the UHECR data with energies above ∼50 EeV are provided by the Pierre Auger Observatory and the Telescope Array. All experiments provide increased statistics and improved reconstructions with respect to our previous results reported in 2015. The first analysis uses a high-statistics neutrino sample optimized for point-source searches to search for excesses of neutrino clustering in the vicinity of UHECR directions. The second analysis searches for an excess of UHECRs in the direction of the highest-energy neutrinos. The third analysis searches for an excess of pairs of UHECRs and highest-energy neutrinos on different angular scales. None of the analyses have found a significant excess, and previously reported overfluctuations are reduced in significance. Based on these results, we further constrain the neutrino flux spatially correlated with UHECRs.
Published: 2022

2. Combined search for neutrinos from dark matter self-annihilation in the Galactic Center with ANTARES and IceCube

Author: Albert, A, Andre, M, Anghinolfi, M, Ardid, M, Aubert, J-J, Aublin, J, Baret, B, Basa, S, Belhorma, B, Bertin, V, Biagi, S, Bissinger, M, Boumaaza, J, Bouta, M, Bouwhuis, MC, Branzas, H, Bruijn, R, Brunner, J, Busto, J, Capone, A, Caramete, L, Carr, J, Celli, S, Chabab, M, Chau, TN, El Moursli, R Cherkaoui, Chiarusi, T, Circella, M, Coleiro, A, Colomer, M, Coniglione, R, Coyle, P, Creusot, A, Diaz, AF, Deschamps, A, Distefano, C, Di Palma, I, Domi, A, Donzaud, C, Dornic, D, Drouhin, D, Eberl, T, El Khayati, N, Enzenhoefer, A, Ettahiri, A, Fermani, P, Ferrara, G, Filippini, F, Fusco, L, Gay, P, Glotin, H, Gozzini, R, Ruiz, R Gracia, Graf, K, Guidi, C, Hallmann, S, van Haren, H, Heijboer, AJ, Hello, Y, Hernandez-Rey, JJ, Hoessl, J, Hofestaedt, J, Huang, F, Illuminati, G, James, CW, de Jong, M, de Jong, P, Jongen, M, Kadler, M, Kalekin, O, Katz, U, Khan-Chowdhury, NR, Kouchner, A, Kreykenbohm, I, Kulikovskiy, V, Lahmann, R, Le Breton, R, Lefevre, D, Leonora, E, Levi, G, Lincetto, M, Lopez-Coto, D, Loucatos, S, Maggi, G, Manczak, J, Marcelin, M, Margiotta, A, Marinelli, A, Martinez-Mora, JA, Mele, R, Melis, K, Migliozzi, P, Moser, M, Moussa, A, Muller, R, Nauta, L, Navas, S, Nezri, E, Nielsen, C, and Nunez-Castineyra, A
Subjects: astro-ph.HE
Abstract: We present the results of the first combined dark matter search targeting theGalactic Centre using the ANTARES and IceCube neutrino telescopes. For darkmatter particles with masses from 50 to 1000 GeV, the sensitivities on theself-annihilation cross section set by ANTARES and IceCube are comparable,making this mass range particularly interesting for a joint analysis. Darkmatter self-annihilation through the $\tau^+\tau^-$, $\mu^+\mu^-$, $b\bar{b}$and $W^+W^-$ channels is considered for both the Navarro-Frenk-White andBurkert halo profiles. In the combination of 2,101.6 days of ANTARES data and1,007 days of IceCube data, no excess over the expected background is observed.Limits on the thermally-averaged dark matter annihilation cross section$\langle\sigma_A\upsilon\rangle$ are set. These limits present an improvementof up to a factor of two in the studied dark matter mass range with respect tothe individual limits published by both collaborations. When considering darkmatter particles with a mass of 200 GeV annihilating through the $\tau^+\tau^-$channel, the value obtained for the limit is $7.44 \times 10^{-24}\text{cm}^{3}\text{s}^{-1}$ for the Navarro-Frenk-White halo profile. For thepurpose of this joint analysis, the model parameters and the likelihood areunified, providing a benchmark for forthcoming dark matter searches performedby neutrino telescopes.
Published: 2020

3. ANTARES and IceCube Combined Search for Neutrino Point-like and Extended Sources in the Southern Sky

Author: Albert, A, André, M, Anghinolfi, M, Anton, G, Ardid, M, Aubert, JJ, Aublin, J, Baret, B, Basa, S, Belhorma, B, Bertin, V, Biagi, S, Bissinger, M, Boumaaza, J, Bourret, S, Bouta, M, Bouwhuis, MC, Brânzaş, H, Bruijn, R, Brunner, J, Busto, J, Capone, A, Caramete, L, Carr, J, Celli, S, Chabab, M, Chau, TN, El Moursli, RC, Chiarusi, T, Circella, M, Coleiro, A, Colomer, M, Coniglione, R, Costantini, H, Coyle, P, Creusot, A, Diáz, AF, Wasseige, GD, Deschamps, A, Distefano, C, Palma, ID, Domi, A, Donzaud, C, Dornic, D, Drouhin, D, Eberl, T, Bojaddaini, IE, Khayati, NE, Elsässer, D, Enzenhöfer, A, Ettahiri, A, Fassi, F, Fermani, P, Ferrara, G, Filippini, F, Fusco, L, Gay, P, Glotin, H, Gozzini, R, Ruiz, RG, Graf, K, Guidi, C, Hallmann, S, Van Haren, H, Heijboer, AJ, Hello, Y, Hernández-Rey, JJ, Hößl, J, Hofestädt, J, Illuminati, G, James, CW, Jong, MD, Jong, PD, Jongen, M, Kadler, M, Kalekin, O, Katz, U, Khan-Chowdhury, NR, Kouchner, A, Kreter, M, Kreykenbohm, I, Kulikovskiy, V, Lahmann, R, Breton, RL, Lefèvre, D, Leonora, E, Levi, G, Lincetto, M, Lopez-Coto, D, Loucatos, S, Maggi, G, Manczak, J, Marcelin, M, Margiotta, A, Marinelli, A, Martínez-Mora, JA, Mele, R, Melis, K, Migliozzi, P, and Moser, M
Subjects: astro-ph.HE, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Physical Chemistry, Astronomy & Astrophysics, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Physical Chemistry (incl. Structural)
Abstract: A search for point-like and extended sources of cosmic neutrinos using data collected by the ANTARES and IceCube neutrino telescopes is presented. The data set consists of all the track-like and shower-like events pointing in the direction of the Southern Sky included in the nine-year ANTARES point-source analysis, combined with the throughgoing track-like events used in the seven-year IceCube point-source search. The advantageous field of view of ANTARES and the large size of IceCube are exploited to improve the sensitivity in the Southern Sky by a factor of ∼2 compared to both individual analyses. In this work, the Southern Sky is scanned for possible excesses of spatial clustering, and the positions of preselected candidate sources are investigated. In addition, special focus is given to the region around the Galactic Center, whereby a dedicated search at the location of SgrA∗ is performed, and to the location of the supernova remnant RXJ 1713.7-3946. No significant evidence for cosmic neutrino sources is found, and upper limits on the flux from the various searches are presented.
Published: 2020

4. Search for Multimessenger Sources of Gravitational Waves and High-energy Neutrinos with Advanced LIGO during Its First Observing Run, ANTARES, and IceCube

Author: Albert, A, André, M, Anghinolfi, M, Ardid, M, Aubert, J-J, Aublin, J, Avgitas, T, Baret, B, Barrios-Martí, J, Basa, S, Belhorma, B, Bertin, V, Biagi, S, Bormuth, R, Boumaaza, J, Bourret, S, Bouwhuis, MC, Brânzaş, H, Bruijn, R, Brunner, J, Busto, J, Capone, A, Caramete, L, Carr, J, Celli, S, Chabab, M, Moursli, R Cherkaoui El, Chiarusi, T, Circella, M, Coelho, JAB, Coleiro, A, Colomer, M, Coniglione, R, Costantini, H, Coyle, P, Creusot, A, Díaz, AF, Deschamps, A, Distefano, C, Di Palma, I, Domi, A, Donà, R, Donzaud, C, Dornic, D, Drouhin, D, Eberl, T, Bojaddaini, I El, Khayati, N El, Elsässer, D, Enzenhöfer, A, Ettahiri, A, Fassi, F, Felis, I, Fermani, P, Ferrara, G, Fusco, L, Gay, P, Glotin, H, Grégoire, T, Ruiz, R Gracia, Graf, K, Hallmann, S, van Haren, H, Heijboer, AJ, Hello, Y, Hernández-Rey, JJ, Hößl, J, Hofestädt, J, Illuminati, G, de Jong, M, Jongen, M, Kadler, M, Kalekin, O, Katz, U, Khan-Chowdhury, NR, Kouchner, A, Kreter, M, Kreykenbohm, I, Kulikovskiy, V, Lachaud, C, Lahmann, R, Lefèvre, D, Leonora, E, Levi, G, Lotze, M, Loucatos, S, Maggi, G, Marcelin, M, Margiotta, A, Marinelli, A, Martínez-Mora, JA, Mele, R, Melis, K, Migliozzi, P, Moussa, A, Navas, S, Nezri, E, Nuñez, A, Organokov, M, and Păvălaş, GE
Subjects: Nuclear and Plasma Physics, Particle and High Energy Physics, Astronomical Sciences, Physical Sciences, gravitational waves, neutrinos, astro-ph.HE, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Physical Chemistry (incl. Structural), Astronomy & Astrophysics, Astronomical sciences, Particle and high energy physics, Space sciences
Abstract: Astrophysical sources of gravitational waves, such as binary neutron star and black hole mergers or core-collapse supernovae, can drive relativistic outflows, giving rise to non-thermal high-energy emission. High-energy neutrinos are signatures of such outflows. The detection of gravitational waves and high-energy neutrinos from common sources could help establish the connection between the dynamics of the progenitor and the properties of the outflow. We searched for associated emission of gravitational waves and high-energy neutrinos from astrophysical transients with minimal assumptions using data from Advanced LIGO from its first observing run O1, and data from the Antares and IceCube neutrino observatories from the same time period. We focused on candidate events whose astrophysical origins could not be determined from a single messenger. We found no significant coincident candidate, which we used to constrain the rate density of astrophysical sources dependent on their gravitational-wave and neutrino emission processes.
Published: 2019

5. Joint Constraints on Galactic Diffuse Neutrino Emission from the ANTARES and IceCube Neutrino Telescopes

Author: Albert, A, André, M, Anghinolfi, M, Ardid, M, Aubert, JJ, Aublin, J, Avgitas, T, Baret, B, Barrios-Martí, J, Basa, S, Belhorma, B, Bertin, V, Biagi, S, Bormuth, R, Boumaaza, J, Bourret, S, Bouwhuis, MC, Brânzaş, H, Bruijn, R, Brunner, J, Busto, J, Capone, A, Caramete, L, Carr, J, Celli, S, Chabab, M, El Moursli, RC, Chiarusi, T, Circella, M, Coelho, JAB, Coleiro, A, Colomer, M, Coniglione, R, Costantini, H, Coyle, P, Creusot, A, Díaz, AF, Deschamps, A, Distefano, C, Palma, ID, Domi, A, Donzaud, C, Dornic, D, Drouhin, D, Eberl, T, Bojaddaini, IE, Khayati, NE, Elsässer, D, Enzenhöfer, A, Ettahiri, A, Fassi, F, Felis, I, Fermani, P, Ferrara, G, Fusco, L, Gay, P, Glotin, H, Grégoire, T, Ruiz, RG, Graf, K, Hallmann, S, Haren, HV, Heijboer, AJ, Hello, Y, Hernández-Rey, JJ, Hößl, J, Hofestädt, J, Illuminati, G, James, CW, Jong, MD, Jongen, M, Kadler, M, Kalekin, O, Katz, U, Khan-Chowdhury, NR, Kouchner, A, Kreter, M, Kreykenbohm, I, Kulikovskiy, V, Lachaud, C, Lahmann, R, Lefèvre, D, Leonora, E, Levi, G, Lotze, M, Loucatos, S, Marcelin, M, Margiotta, A, Marinelli, A, Martínez-Mora, JA, Mele, R, Melis, K, Migliozzi, P, Moussa, A, Navas, S, Nezri, E, Nuñez, A, Organokov, M, Pǎvǎlaş, GE, and Pellegrino, C
Subjects: astro-ph.HE, Astronomy & Astrophysics, Astronomical and Space Sciences
Abstract: The existence of diffuse Galactic neutrino production is expected from cosmic-ray interactions with Galactic gas and radiation fields. Thus, neutrinos are a unique messenger offering the opportunity to test the products of Galactic cosmic-ray interactions up to energies of hundreds of TeV. Here we present a search for this production using ten years of Astronomy with a Neutrino Telescope and Abyss environmental RESearch (ANTARES) track and shower data, as well as seven years of IceCube track data. The data are combined into a joint likelihood test for neutrino emission according to the KRAg model assuming a 5 PeV per nucleon Galactic cosmic-ray cutoff. No significant excess is found. As a consequence, the limits presented in this Letter start constraining the model parameter space for Galactic cosmic-ray production and transport.
Published: 2018

6. Barriers to achieving sustainability in pharmaceutical supply chains in the post-COVID-19 era

Author: Liza, SA, Chowdhury, NR, Paul, SK, Morshed, M, Morshed, SM, Bhuiyan, MAT, Rahim, MA, Liza, SA, Chowdhury, NR, Paul, SK, Morshed, M, Morshed, SM, Bhuiyan, MAT, and Rahim, MA
Abstract: Purpose The recent pandemic caused by coronavirus disease 2019 (COVID-19) has significantly impacted the operational performances of pharmaceutical supply chains (SCs), especially in emerging economies that are critically vulnerable due to their inadequate resources. Finding the possible barriers that continue to impede the sustainable performance of SCs in the post-COVID-19 era has become essential. This study aims to investigate and analyze the barriers to achieving sustainability in the pharmaceutical SC of an emerging economy in a bid to help decision-makers recognize the most influential barriers. Design/methodology/approach To achieve the goals, two decision-making tools are integrated to analyze the most critical barriers: interpretive structural modeling (ISM) and the matrix of cross-impact multiplications applied to classification (MICMAC). In contrast to other multi-criteria decision-making (MCDM) approaches, ISM develops a hierarchical decision tool for decision-makers and cluster analysis of the barriers using the MICMAC method based on their driving and dependency powers. Findings The findings reveal that the major barriers are in a four-level hierarchical relationship where “Insufficient SC strategic plans to ensure agility during crisis” acts as the most critical barrier, followed by “Poor information structure among SC contributors,” and “Inadequate risk management policy under pandemic.” Finally, the MICMAC analysis validates the findings from the ISM approach. Originality/value This study provides meaningful insights into barriers to achieving sustainability in pharmaceutical SCs in the post-COVID-19 era. The study can help pharmaceutical SC practitioners to better understand what can go wrong in post-COVID-19, and develop actionable strategies to ensure sustainability and resilience in practitioners' SCs.
Published: 2023

7. Implementing smart waste management system for a sustainable circular economy in the textile industry

Author: Chowdhury, NR, Paul, SK, Sarker, T, Shi, Y, Chowdhury, NR, Paul, SK, Sarker, T, and Shi, Y
Abstract: In recent years, global supply chains (SCs) have envisioned redesigning their sourcing, production, and distribution processes due to sustainable production and consumption progression. This has led to the concept of a zero-waste circular economy (CE), which is gaining increasing attention in both developed and emerging economies. The textile industry, in particular, has a significant environmental impact due to the use of toxic chemicals and the production of toxic waste throughout the clothing value chain. While the textile industry in emerging economies is increasingly attempting to transition to a CE model by implementing Smart Waste Management Systems (SWMS), challenges persist due to the complex industry structure involving numerous stakeholders, changing consumer behavior, and lack of strong standards. To address this significant issue, this study addresses challenges faced by the textile industry in adopting SWMS, specifically in the context of an emerging economy. To systematically identify the significant challenges and analyze strategies to address these challenges, a research framework using a hybrid approach, namely the grey Analytical Network Process (ANP), has been developed. The study uses a case study of the textile industry in Bangladesh to validate the effectiveness of the framework. The findings suggest efficient monitoring and control of waste recovery is the most critical step in adopting SWMS. This study offers detailed and comparative insights into the framework of implementing SWMS in the textile industry. Additionally, this research is the first to undertake an analytical decision approach to map challenges and strategies in implementing SWMS. The study outcomes will be beneficial for industry practitioners to ensure efficient monitoring and control of waste recovery and help the industry move towards a sustainable CE.
Published: 2023

8. Sustainable practices and their antecedents in the apparel industry: A review

Author: Chowdhury, NR, Chowdhury, P, and Paul, SK
Published: 2022

9. Search for non-standard neutrino interactions with 10 years of ANTARES data

Author: Albert, A, Alves, S, Andre, M, Anghinolfi, M, Anton, G, Ardid, M, Ardid, S, Aubert, J-J, Aublin, J, Baret, B, Basa, S, Belhorma, B, Bendahman, M, Benfenati, F, Bertin, V, Biagi, S, Bissinger, M, Boumaaza, J, Bouta, M, Bouwhuis, MC, Branzas, H, Bruijn, R, Brunner, J, Busto, J, Caiffi, B, Calvo, D, Capone, A, Caramete, L, Carr, J, Carretero, V, Celli, S, Chabab, M, Chau, TN, El Moursli, R Cherkaoui, Chiarusi, T, Circella, M, Coleiro, A, Coniglione, R, Coyle, P, Creusot, A, Diaz, AF, de Wasseige, G, Distefano, C, Di Palma, I, Domi, A, Donzaud, C, Dornic, D, Drouhin, D, Eberl, T, van Eeden, T, van Eijk, D, El Khayati, N, Enzenhofer, A, Fermani, P, Ferrara, G, Filippini, F, Fusco, L, Gatelet, Y, Gay, P, Glotin, H, Gozzini, R, Ruiz, R Gracia, Graf, K, Guidi, C, Hallmann, S, van Haren, H, Heijboer, AJ, Hello, Y, Hernandez-Rey, JJ, Hoel, J, Hofestaedt, J, Huang, F, Illuminati, G, James, CW, Jisse-Jung, B, de Jong, M, de Jong, P, Kadler, M, Kalekin, O, Katz, U, Khan-Chowdhury, NR, Kouchner, A, Kreykenbohm, I, Kulikovskiy, V, Lahmann, R, Le Breton, R, LeStum, S, Lefevre, D, Leonora, E, Levi, G, Lincetto, M, Lopez-Coto, D, Loucatos, S, Maderer, L, Manczak, J, Marcelin, M, Margiotta, A, Marinelli, A, Martinez-Mora, JA, Martino, B, Melis, K, Migliozzi, P, Moussa, A, Muller, R, Nauta, L, Navas, S, Nezri, E, Fearraigh, BO, Paun, A, Pavalas, GE, Pellegrino, C, Perrin-Terrin, M, Pestel, V, Piattelli, P, Pieterse, C, Poire, C, Popa, V, Pradier, T, Randazzo, N, Real, D, Reck, S, Riccobene, G, Romanov, A, Sanchez-Losa, A, Salesa Greus, F, Samtleben, DFE, Sanguineti, M, Sapienza, P, Schnabel, J, Schumann, J, Schussler, F, Seneca, J, Spurio, M, Stolarczyk, Th, Taiuti, M, Tayalati, Y, Thakore, T, Tingay, SJ, Vallage, B, Van Elewyck, V, Versari, F, Viola, S, Vivolo, D, Wilms, J, Zavatarelli, S, Zegarelli, A, Zornoza, JD, Zuniga, J, Albert, A, Alves, S, Andre, M, Anghinolfi, M, Anton, G, Ardid, M, Ardid, S, Aubert, JJ, Aublin, J, Baret, B, Basa, S, Belhorma, B, Bendahman, M, Benfenati, F, Bertin, V, Biagi, S, Bissinger, M, Boumaaza, J, Bouta, M, Bouwhuis, MC, Bruijn, R, Brunner, J, Busto, J, Caiffi, B, Calvo, D, Capone, A, Caramete, L, Carr, J, Carretero, V, Celli, S, Chabab, M, Chau, TN, El Moursli, RC, Chiarusi, T, Circella, M, Coleiro, A, Coniglione, R, Coyle, P, Creusot, A, Diaz, AF, de Wasseige, G, Distefano, C, Di Palma, I, Domi, A, Donzaud, C, Dornic, D, Drouhin, D, Eberl, T, van Eeden, T, van Eijk, D, El Khayati, N, Enzenhofer, A, Fermani, P, Ferrara, G, Filippini, F, Fusco, L, Gatelet, Y, Gay, P, Glotin, H, Gozzini, R, Ruiz, RG, Graf, K, Guidi, C, Hallmann, S, van Haren, H, Heijboer, AJ, Hello, Y, Hernandez-Rey, JJ, Hol, J, Hofestadt, J, Huang, F, Illuminati, G, James, CW, Jisse-Jung, B, de Jong, M, de Jong, P, Kadler, M, Kalekin, O, Katz, U, Khan-Chowdhury, NR, Kouchner, A, Kreykenbohm, I, Kulikovskiy, V, Lahmann, R, Le Breton, R, LeStum, S, Lefevre, D, Leonora, E, Levi, G, Lincetto, M, Lopez-Coto, D, Loucatos, S, Maderer, L, Manczak, J, Marcelin, M, Margiotta, A, Marinelli, A, Martinez-Mora, JA, Martino, B, Melis, K, Migliozzi, P, Moussa, A, Muller, R, Nauta, L, Navas, S, Nezri, E, Fearraigh, BO, Pellegrino, C, Perrin-Terrin, M, Pestel, V, Piattelli, P, Pieterse, C, Poire, C, Popa, V, Pradier, T, Randazzo, N, Real, D, Reck, S, Riccobene, G, Romanov, A, Sanchez-Losa, A, Greus, FS, Samtleben, DFE, Sanguineti, M, Sapienza, P, Schnabel, J, Schumann, J, Schussler, F, Seneca, J, Spurio, M, Stolarczyk, T, Taiuti, M, Tayalati, Y, Thakore, T, Tingay, SJ, Vallage, B, Van Elewyck, V, Versari, F, Viola, S, Vivolo, D, Wilms, J, Zavatarelli, S, Zegarelli, A, Zornoza, JD, Zuniga, J, KM3NeT (IHEF, IoP, FNWI), ANTARES (IHEF, IoP, FNWI), Astroparticle Physics (IHEF, IoP, FNWI), ATLAS (IHEF, IoP, FNWI), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Groupe de Recherche en Physique des Hautes Energies (GRPHE), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-IUT de Colmar, Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Laboratoire d'Informatique et Systèmes (LIS), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut méditerranéen d'océanologie (MIO), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), ANTARES, ANR-18-IDEX-0001,Université de Paris,Université de Paris(2018), Centre Tecnològic de Vilanova i la Geltrú, and Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques
Subjects: Astrofísica, data analysis method, Nuclear and High Energy Physics, FOS: Physical sciences, Physics, Particles & Fields, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), statistical analysis, neutrino: atmosphere, neutrino: new interaction, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Neutrins, neutrino: interaction, BARYON, Science & Technology, ANTARES, neutrino: energy spectrum, Physics, new physics: search for, matter: effect, Neutrino Detectors and Telescopes (experiments), Neutrino astrophysics, neutrino: propagation, neutrino: detector, Física::Astronomia i astrofísica [Àrees temàtiques de la UPC], FISICA APLICADA, Physical Sciences, neutrino: flavor, High Energy Physics::Experiment, neutrino: oscillation, experimental results
Abstract: Non-standard interactions of neutrinos arising in many theories beyond the Standard Model can significantly alter matter effects in atmospheric neutrino propagation through the Earth. In this paper, a search for deviations from the prediction of the standard 3-flavour atmospheric neutrino oscillations using the data taken by the ANTARES neutrino telescope is presented. Ten years of atmospheric neutrino data collected from 2007 to 2016, with reconstructed energies in the range from similar to 16 GeV to 100 GeV, have been analysed. A log-likelihood ratio test of the dimensionless coefficients epsilon(mu tau) and epsilon(tau tau) - epsilon(mu mu) does not provide clear evidence of deviations from standard interactions. For normal neutrino mass ordering, the combined fit of both coefficients yields a value 1.7 sigma away from the null result. However, the 68% and 95% confidence level intervals for epsilon(mu tau) and epsilon(tau tau) - epsilon(mu mu), respectively, contain the null value. Best fit values, one standard deviation errors and bounds at the 90% confidence level for these coefficients are given for both normal and inverted mass orderings. The constraint on epsilon(mu tau) is among the most stringent to date and it further restrains the strength of possible non-standard interactions in the mu - tau sector., Centre National de la Recherche Scientifique (CNRS), French Atomic Energy Commission, Commission Europeenne (FEDER fund), Commission Europeenne (Marie Curie Program), Institut Universitaire de France (IUF), LabEx UnivEarthS ANR-10-LABX-0023 ANR-18-IDEX-0001, Region Ile-de-France Region Grand-Est Region Provence-Alpes-Cote d'Azur, Federal Ministry of Education & Research (BMBF), Istituto Nazionale di Fisica Nucleare (INFN), Netherlands Organization for Scientific Research (NWO) Netherlands Government, Council of the President of the Russian Federation for young scientists and leading scientific schools supporting grants, Russia, Consiliul National al Cercetarii Stiintifice (CNCS), Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii (UEFISCDI), Ministerio de Ciencia, Innovacion, Investigacion y Universidades (MCIU): Programa Estatal de Generacion de Conocimiento PGC2018-096663-B-C41 PGC2018-096663-A-C42 PGC2018-096663-B-C43 PGC2018-096663-B-C44, Center for Forestry Research & Experimentation (CIEF), European Commission PROMETEO/2020/019 GRISOLIA/2018/119,/2021/192 CIDEGENT/2018/034,/2019/043,/2020/049,/2021/023, Junta de Andalucia A-FQM-053-UGR18 t, La Caixa Foundation LCF/BQ/IN17/11620019, EU: MSC program, Spain 101025085, Ministry of Higher Education, Scientific Research and Innovation, Morocco, Arab Fund for Economic and Social Developmen
Published: 2022

10. Modeling a sustainable vaccine supply chain for a healthcare system

Author: Chowdhury, NR, Ahmed, M, Mahmud, P, Paul, SK, and Liza, SA
Subjects: 0907 Environmental Engineering, 0910 Manufacturing Engineering, 0915 Interdisciplinary Engineering, Environmental Sciences
Abstract: This study develops a vaccine supply chain (VSC) to ensure sustainable distribution during a global crisis in a developing economy. In this study, a multi-objective mixed-integer programming (MIP) model is formulated to develop the VSC, ensuring the entire network’s economic performance. This is achieved by minimizing the overall cost of vaccine distribution and ensuring environmental and social sustainability by minimizing greenhouse gas (GHG) emissions and maximizing job opportunities in the entire network. The shelf-life of vaccines and the uncertainty associated with demand and supply chain (SC) parameters are also considered in this study to ensure the robustness of the model. To solve the model, two recently developed metaheuristics—namely, the multi-objective social engineering optimizer (MOSEO) and multi-objective feasibility enhanced particle swarm optimization (MOFEPSO) methods—are used, and their results are compared. Further, the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) model has been integrated into the optimization model to determine the best solution from a set of non-dominated solutions (NDSs) that prioritize environmental sustainability. The results are analyzed in the context of the Bangladeshi coronavirus disease (COVID-19) vaccine distribution systems. Numerical illustrations reveal that the MOSEO-TOPSIS model performs substantially better in designing the network than the MOFEPSO-TOPSIS model. Furthermore, the solution from MOSEO results in achieving better environmental sustainability than MOFEPSO with the same resources. Results also reflect that the proposed MOSEO-TOPSIS can help policymakers establish a VSC during a global crisis with enhanced economic, environmental, and social sustainability within the healthcare system.
Published: 2022

11. Search for Spatial Correlations of Neutrinos with Ultra-high-energy Cosmic Rays

Author: Albert, A, Albert, A, Alves, S, André, M, Anghinolfi, M, Ardid, S, Aubert, JJ, Aublin, J, Baret, B, Basa, S, Belhorma, B, Bendahman, M, Bertin, V, Biagi, S, Bissinger, M, Boumaaza, J, Bouta, M, Bouwhuis, MC, Brânzaş, H, Bruijn, R, Brunner, J, Busto, J, Caiffi, B, Calvo, D, Capone, A, Caramete, L, Carr, J, Carretero, V, Celli, S, Chabab, M, Chau, TN, Cherkaoui El Moursli, R, Chiarusi, T, Circella, M, Coleiro, A, Coniglione, R, Coyle, P, Creusot, A, Díaz, AF, Distefano, C, Di Palma, I, Domi, A, Donzaud, C, Dornic, D, Drouhin, D, Eberl, T, van Eeden, T, van Eijk, D, El Khayati, N, Enzenhöfer, A, Fermani, P, Ferrara, G, Filippini, F, Fusco, L, Gatelet, Y, Gay, P, Glotin, H, Gozzini, R, Gracia Ruiz, R, Graf, K, Guidi, C, Hallmann, S, van Haren, H, Heijboer, AJ, Hello, Y, Hernández-Rey, JJ, Hössl, J, Hofestädt, J, Huang, F, Illuminati, G, James, CW, Jisse-Jung, B, De Jong, M, de Jong, P, Kadler, M, Kalekin, O, Katz, U, Khan-Chowdhury, NR, Kouchner, A, Kreykenbohm, I, Kulikovskiy, V, Lahmann, R, Le Breton, R, LeStum, S, Lefèvre, D, Leonora, E, Levi, G, Lopez-Coto, D, Loucatos, S, Maderer, L, Manczak, J, Marcelin, M, Margiotta, A, Marinelli, A, Martínez-Mora, JA, Martino, B, Melis, K, Migliozzi, P, Moussa, A, Muller, R, Nauta, L, Albert, A, Albert, A, Alves, S, André, M, Anghinolfi, M, Ardid, S, Aubert, JJ, Aublin, J, Baret, B, Basa, S, Belhorma, B, Bendahman, M, Bertin, V, Biagi, S, Bissinger, M, Boumaaza, J, Bouta, M, Bouwhuis, MC, Brânzaş, H, Bruijn, R, Brunner, J, Busto, J, Caiffi, B, Calvo, D, Capone, A, Caramete, L, Carr, J, Carretero, V, Celli, S, Chabab, M, Chau, TN, Cherkaoui El Moursli, R, Chiarusi, T, Circella, M, Coleiro, A, Coniglione, R, Coyle, P, Creusot, A, Díaz, AF, Distefano, C, Di Palma, I, Domi, A, Donzaud, C, Dornic, D, Drouhin, D, Eberl, T, van Eeden, T, van Eijk, D, El Khayati, N, Enzenhöfer, A, Fermani, P, Ferrara, G, Filippini, F, Fusco, L, Gatelet, Y, Gay, P, Glotin, H, Gozzini, R, Gracia Ruiz, R, Graf, K, Guidi, C, Hallmann, S, van Haren, H, Heijboer, AJ, Hello, Y, Hernández-Rey, JJ, Hössl, J, Hofestädt, J, Huang, F, Illuminati, G, James, CW, Jisse-Jung, B, De Jong, M, de Jong, P, Kadler, M, Kalekin, O, Katz, U, Khan-Chowdhury, NR, Kouchner, A, Kreykenbohm, I, Kulikovskiy, V, Lahmann, R, Le Breton, R, LeStum, S, Lefèvre, D, Leonora, E, Levi, G, Lopez-Coto, D, Loucatos, S, Maderer, L, Manczak, J, Marcelin, M, Margiotta, A, Marinelli, A, Martínez-Mora, JA, Martino, B, Melis, K, Migliozzi, P, Moussa, A, Muller, R, and Nauta, L
Abstract: For several decades, the origin of ultra-high-energy cosmic rays (UHECRs) has been an unsolved question of high-energy astrophysics. One approach for solving this puzzle is to correlate UHECRs with high-energy neutrinos, since neutrinos are a direct probe of hadronic interactions of cosmic rays and are not deflected by magnetic fields. In this paper, we present three different approaches for correlating the arrival directions of neutrinos with the arrival directions of UHECRs. The neutrino data are provided by the IceCube Neutrino Observatory and ANTARES, while the UHECR data with energies above ∼50 EeV are provided by the Pierre Auger Observatory and the Telescope Array. All experiments provide increased statistics and improved reconstructions with respect to our previous results reported in 2015. The first analysis uses a high-statistics neutrino sample optimized for point-source searches to search for excesses of neutrino clustering in the vicinity of UHECR directions. The second analysis searches for an excess of UHECRs in the direction of the highest-energy neutrinos. The third analysis searches for an excess of pairs of UHECRs and highest-energy neutrinos on different angular scales. None of the analyses have found a significant excess, and previously reported overfluctuations are reduced in significance. Based on these results, we further constrain the neutrino flux spatially correlated with UHECRs.
Published: 2022

12. The Search for Neutrinos from TXS 0506+056 with the ANTARES Telescope

Author: Albert A, Andre M, Anghinolfi M, Anton G, Ardid M, Aubert JJ, Aublin J, Avgitas T, Baret B, Barrios-Marti J, Basa S, Belhorma B, Benin V, Biagi S, Bormuth R, Boumaaza J, Bourret S, Bouwhuis MC, Branzas H, Bruijn R, Brunner J, Busto J, Capone A, Caramete L, Carr J, Celli S, Chabab M, El Moursli RC, Chiarusi T, Circella M, Coelho JAB, Coleiro A, Colomer M, Coniglione R, Costantini H, Coyle P, Creusot A, Diaz AF, Deschamps A, Distefano C, Di Palma I, Domi A, Dona R, Donzaud C, Dornic D, Drouhin D, Eberl T, El Bojaddaini I, El Khayati N, Elsasser D, Enzenhofer A, Ettahiri A, Fassi F, Felis I, Fermani P, Ferrara G, Fusco L, Gay P, Glotin H, Gregoire T, Ruiz TG, Graf K, Hallmann S, van Haren H, Heijboer AJ, Hello Y, Hernandez-Rey J, Hossl J, Hofestadt J, Illuminati G, de Jong M, Jongen M, Kadler M, Kalekin O, Katz U, Khan-Chowdhury NR, Kouchner A, Kreter M, Kreykenbohm I, Kulikovskiy V, Lachaud C, Lahmann R, Lefevre D, Leonora E, Lotze M, Loucatos S, Marcelin M, Margiotta A, Marinelli A, Martinez-Mora JA, Mele R, Melis K, Migliozzi P, Moussa A, Navas S, Nezri E, Nunez A, Organokov M, Pavalas GE, Pellegrino C, Piattelli P, Popa V, Pradier T, Quinn L, Racca C, Randazzo N, Riccobene G, Sanchez-Losa A, Saldana M, Salvadori I, Samtleben DFE, Sanguineti M, Sapienza P, Schussler F, Spurio M, Stolarczyk T, Taiuti M, Tayalati Y, Trovato A, Vallage B, Van Elewyck V, Versari F, Vivolo D, Wilms J, Zaborov D, Zornoza JD, Zuniga J, Albert, A, Andre, M, Anghinolfi, M, Anton, G, Ardid, M, Aubert, Jj, Aublin, J, Avgitas, T, Baret, B, Barrios-Marti, J, Basa, S, Belhorma, B, Benin, V, Biagi, S, Bormuth, R, Boumaaza, J, Bourret, S, Bouwhuis, Mc, Branzas, H, Bruijn, R, Brunner, J, Busto, J, Capone, A, Caramete, L, Carr, J, Celli, S, Chabab, M, El Moursli, Rc, Chiarusi, T, Circella, M, Coelho, Jab, Coleiro, A, Colomer, M, Coniglione, R, Costantini, H, Coyle, P, Creusot, A, Diaz, Af, Deschamps, A, Distefano, C, Di Palma, I, Domi, A, Dona, R, Donzaud, C, Dornic, D, Drouhin, D, Eberl, T, El Bojaddaini, I, El Khayati, N, Elsasser, D, Enzenhofer, A, Ettahiri, A, Fassi, F, Felis, I, Fermani, P, Ferrara, G, Fusco, L, Gay, P, Glotin, H, Gregoire, T, Ruiz, Tg, Graf, K, Hallmann, S, van Haren, H, Heijboer, Aj, Hello, Y, Hernandez-Rey, J, Hossl, J, Hofestadt, J, Illuminati, G, de Jong, M, Jongen, M, Kadler, M, Kalekin, O, Katz, U, Khan-Chowdhury, Nr, Kouchner, A, Kreter, M, Kreykenbohm, I, Kulikovskiy, V, Lachaud, C, Lahmann, R, Lefevre, D, Leonora, E, Lotze, M, Loucatos, S, Marcelin, M, Margiotta, A, Marinelli, A, Martinez-Mora, Ja, Mele, R, Melis, K, Migliozzi, P, Moussa, A, Navas, S, Nezri, E, Nunez, A, Organokov, M, Pavalas, Ge, Pellegrino, C, Piattelli, P, Popa, V, Pradier, T, Quinn, L, Racca, C, Randazzo, N, Riccobene, G, Sanchez-Losa, A, Saldana, M, Salvadori, I, Samtleben, Dfe, Sanguineti, M, Sapienza, P, Schussler, F, Spurio, M, Stolarczyk, T, Taiuti, M, Tayalati, Y, Trovato, A, Vallage, B, Van Elewyck, V, Versari, F, Vivolo, D, Wilms, J, Zaborov, D, Zornoza, Jd, Zuniga, J, KM3NeT (IHEF, IoP, FNWI), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Informatique et Systèmes (LIS), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Institut méditerranéen d'océanologie (MIO), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Groupe de Recherche en Physique des Hautes Energies (GRPHE), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-IUT de Colmar, Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), ANTARES, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut Universitaire de Technologie de Colmar, Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de Technologie de Colmar-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Albert, A., Andre, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J. -J., Aublin, J., Avgitas, T., Baret, B., Barrios-Marti, J., Basa, S., Belhorma, B., Bertin, V., Biagi, S., Bormuth, R., Boumaaza, J., Bourret, S., Bouwhuis, M. C., Branzas, H., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Celli, S., Chabab, M., El Moursli, R. C., Chiarusi, T., Circella, M., Coelho, J. A. B., Coleiro, A., Colomer, M., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., Diaz, A. F., Deschamps, A., Distefano, C., Palma, I. D., Domi, A., Dona, R., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., Bojaddaini, I. E., Khayati, N. E., Elsasser, D., Enzenhofer, A., Ettahiri, A., Fassi, F., Felis, I., Fermani, P., Ferrara, G., Fusco, L., Gay, P., Glotin, H., Gregoire, T., Ruiz, R. G., Graf, K., Hallmann, S., Haren, H. V., Heijboer, A. J., Hello, Y., Hernandez-Rey, J. J., Hossl, J., Hofestadt, J., Illuminati, G., Jong, M. D., Jongen, M., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N. R., Kouchner, A., Kreter, M., Kreykenbohm, I., Kulikovskiy, V., Lachaud, C., Lahmann, R., Lefevre, D., Leonora, E., Lotze, M., Loucatos, S., Marcelin, M., Margiotta, A., Marinelli, A., Martinez-Mora, J. A., Mele, R., Melis, K., Migliozzi, P., Moussa, A., Navas, S., Nezri, E., Nunez, A., Organokov, M., Pavalas, G. E., Pellegrino, C., Piattelli, P., Popa, V., Pradier, T., Quinn, L., Racca, C., Randazzo, N., Riccobene, G., Sanchez-Losa, A., Saldana, M., Salvadori, I., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schussler, F., Spurio, M., Stolarczyk, T., Taiuti, M., Tayalati, Y., Trovato, A., Vallage, B., Elewyck, V. V., Versari, F., Vivolo, D., Wilms, J., Zaborov, D., Zornoza, J. D., Zuniga, J., Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Centre National de la Recherche Scientifique (CNRS)-Université de Toulon (UTLN)-Aix Marseille Université (AMU)-Institut de Recherche pour le Développement (IRD), André, M., Aubert, J.-J., Barrios-Martí, J., Brânzaş, H., El Moursli, R. Cherkaoui, Díaz, A. F., Palma, I. Di, Donà, R., Bojaddaini, I. El, Khayati, N. El, Elsässer, D., Enzenhöfer, A., Grégoire, T., Ruiz, R. Gracia, Haren, H. van, Hernández-Rey, J. J., Hößl, J., Hofestädt, J., Jong, M. de, Lefèvre, D., Martínez-Mora, J. A., Nuñez, A., Păvălaş, G. E., Sánchez-Losa, A., Saldaña, M., Schüssler, F., Stolarczyk, Th., Elewyck, V. Van, Zúñiga, J., Centre Tecnològic de Vilanova i la Geltrú, and Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques
Subjects: Astrofísica, astroparticle physics, elementary particles, galaxies: active, Astronomy and Astrophysics, Space and Planetary Science, FOS: Physical sciences, Library science, astro-ph.HE, Astrophysics, 01 natural sciences, National authority, IceCube, Marie curie, Bildung, astroparticle physics – elementary particles – galaxies: active, 0103 physical sciences, elementary particle, Neutrins, Neutrinos, 010303 astronomy & astrophysics, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, ANTARES, Telescopis, 010308 nuclear & particles physics, Elementary particles, astroparticle physic, neutrino: detector, Física::Astronomia i astrofísica [Àrees temàtiques de la UPC], FISICA APLICADA, active [galaxies], time dependence, Christian ministry, Russian federation, galaxy, Astroparticle physics, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], on-line, Telescopes
Abstract: [EN] The results of three different searches for neutrino candidates, associated with the IceCube-170922A event or from the direction of TXS 0506+056, by the ANTARES neutrino telescope, are presented. The ¿rst search refers to the online follow-up of the IceCube alert; the second is based on the standard time-integrated method employed by the Collaboration to search for point-like neutrino sources; the third uses information from the IceCube time-dependent analysis that reported bursting activity centered on 2014 December 13, as input for an ANTARES time-dependent analysis. The online follow-up and the time-dependent analysis yield no events related to the source. The time-integrated study performed over a period from 2007 to 2017 ¿ts 1.03 signal events, which corresponds to a p-value of 3.4% (not considering trial factors). Only for two other astrophysical objects in our candidate list has a smaller p-value been found. When considering that 107 sources have been investigated, the post-trial p-value for TXS 0506+056 corresponds to 87%., We thank the IceCube Collaboration for sharing information before the public release. The authors acknowledge the financial support of the funding agencies: Centre National de la Recherche Scientifique (CNRS), Commissariat a l'energie atomique et aux energies alternatives (CEA), Commission Europeenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), IdEx program and UnivEarthS Labex program at Sorbonne Paris Cite (ANR-10-LABX-0023 and ANR-11-IDEX-0005-02), Labex OCEVU (ANR-11-LABX-0060) and the A*MIDEX project (ANR-11-IDEX-0001-02), Region Ile-de-France (DIM-ACAV), Region Alsace (contrat CPER), Region Provence-Alpes-Cote d'Azur, Departement du Var and Ville de La Seyne-sur-Mer, France; Bundesministerium fur Bildung und Forschung (BMBF), Germany; Istituto Nazionale di Fisica Nucleare (INFN), Italy; Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO), the Netherlands; Council of the President of the Russian Federation for young scientists and leading scientific schools supporting grants, Russia; National Authority for Scientific Research (ANCS), Romania; Ministerio de Economia y Competitividad (MINECO): Plan Estatal de Investigacion (refs. FPA2015-65150-C3-1-P, -2-P and -3-P, (MINECO/FEDER)), Severo Ochoa Centre of Excellence and MultiDark Consolider (MINECO), and Prometeo and Grisolia programs (Generalitat Valenciana), Spain; Ministry of Higher Education, Scientific Research and Professional Training, Morocco. We also acknowledge the technical support of Ifremer, AIM, and Foselev Marine for the sea operation and the CC-IN2P3 for the computing facilities.
Published: 2018

13. Kernicterus in an adult who is heterozygous for Crigler-Najjar syndrome and homozygous for Gilbert-type genetic defect

Author: Chalasani, N, primary, Chowdhury, NR, additional, Chowdhury, JR, additional, and Boyer, TD, additional
Published: 1997
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14. ANTARES and IceCube Combined Search for Neutrino Point-like and Extended Sources in the Southern Sky

Author: Antares, Collaboration, Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J. -J., Aublin, J., Baret, B., Basa, S., Belhorma, B., Bertin, V., Biagi, S., Bissinger, M., Boumaaza, J., Bourret, S., Bouta, M., Bouwhuis, M. C., Brânzaş, H., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Celli, S., Chabab, M., Chau, T. N., Cherkaoui El Moursli, R., Chiarusi, T., Circella, M., Coleiro, A., Colomer, M., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., Díaz, A. F., de Wasseige, G., Deschamps, A., Distefano, C., Di Palma, I., Domi, A., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., El Bojaddaini, I., El Khayati, N., Elsässer, D., Enzenhöfer, A., Ettahiri, A., Fassi, F., Fermani, P., Ferrara, G., Filippini, F., Fusco, L., Gay, P., Glotin, H., Gozzini, R., Gracia Ruiz, R., Graf, K., Guidi, C., Hallmann, S., van Haren, H., Heijboer, A. J., Hello, Y., Hernández-Rey, J. J., Hößl, J., Hofestädt, J., Illuminati, G., James, C. W., de Jong, M., de Jong, P., Jongen, M., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N. R., Kouchner, A., Kreter, M., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Le Breton, R., Lefèvre, D., Leonora, E., Levi, G., Lincetto, M., Lopez-Coto, D., Loucatos, S., Maggi, G., Manczak, J., Marcelin, M., Margiotta, A., Marinelli, A., Martínez-Mora, J. A., Mele, R., Melis, K., Migliozzi, P., Moser, M., Moussa, A., Muller, R., Nauta, L., Navas, S., Nezri, E., Nielsen, C., Nuñez-Castiñeyra, A., O'Fearraigh, B., Organokov, M., Păvălaş, G. E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Poirè, C., Popa, V., Pradier, T., Quinn, L., Randazzo, N., Riccobene, G., Sánchez-Losa, A., Salah-Eddine, A., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schüssler, F., Spurio, M., Stolarczyk, Th., Strandberg, B., Taiuti, M., Tayalati, Y., Thakore, T., Tingay, S. J., Trovato, A., Vallage, B., Van Elewyck, V., Versari, F., Viola, S., Vivolo, D., Wilms, J., Zaborov, D., Zegarelli, A., Zornoza, J. D., Zúñiga, J., Icecube, Collaboration, Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Andeen, K., Anderson, T., Ansseau, I., Argüelles, C., Auffenberg, J., Axani, S., Backes, P., Bagherpour, H., Bai, X., A. Balagopal V., Barbano, A., Barwick, S. W., Bastian, B., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Becker Tjus, J., Benzvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bohm, C., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Buscher, J., Busse, R. S., Carver, T., Chen, C., Cheung, E., Chirkin, D., Choi, S., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., De Clercq, C., Delaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., Deyoung, T., Diaz, A., Díaz-Vélez, J. C., Dujmovic, H., Dunkman, M., Dvorak, E., Eberhardt, B., Ehrhardt, T., Eller, P., Engel, R., Evenson, P. A., Fahey, S., Fazely, A. R., Felde, J., Filimonov, K., Finley, C., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Ghorbani, K., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Grant, D., Grégoire, T., Griffith, Z., Griswold, S., Günder, M., Gündüz, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hanson, K., Haungs, A., Hebecker, D., Heereman, D., Heix, P., Helbing, K., Hellauer, R., Henningsen, F., Hickford, S., Hignight, J., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jero, K., Jones, B. J. P., Jonske, F., Joppe, R., Kang, D., Kang, W., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Kauer, M., Kelley, J. L., Kheirandish, A., Kim, J., Kintscher, T., Kiryluk, J., Kittler, T., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Krings, K., Krückl, G., Kulacz, N., Kurahashi, N., Kyriacou, A., Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leszczyńska, A., Leuermann, M., Liu, Q. R., Lohfink, E., Lozano Mariscal, C. J., Lu, L., Lucarelli, F., Lünemann, J., Luszczak, W., Lyu, Y., W. Y., Ma, Madsen, J., Mahn, K. B. M., Makino, Y., Mallik, P., Mallot, K., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., Maunu, R., Mcnally, F., Meagher, K., Medici, M., Medina, A., Meier, M., Meighen-Berger, S., Merino, G., Meures, T., Micallef, J., Mockler, D., Momenté, G., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Muth, P., Nagai, R., Naumann, U., Neer, G., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Obertacke Pollmann, A., Oehler, M., Olivas, A., O'Murchadha, A., O'Sullivan, E., Palczewski, T., Pandya, H., Pankova, D. V., Park, N., Peiffer, P., Pérez de los Heros, C., Philippen, S., Pieloth, D., Pieper, S., Pinat, E., Pizzuto, A., Plum, M., Porcelli, A., Price, P. B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rauch, L., Rawlins, K., Rea, I. C., Reimann, R., Relethford, B., Renschler, M., Renzi, G., Resconi, E., Rhode, W., Richman, M., Robertson, S., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Rysewyk, D., Safa, I., Sanchez Herrera, S. E., Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Shefali, S., Silva, M., Snihur, R., Soedingrekso, J., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Strotjohann, N. L., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Terliuk, A., Tilav, S., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Ty, B., Unger, E., Unland Elorrieta, M. A., Usner, M., Vandenbroucke, J., Van Driessche, W., van Eijk, D., van Eijndhoven, N., van Santen, J., Verpoest, S., Vraeghe, M., Walck, C., Wallace, A., Wallraff, M., Wandkowsky, N., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Wille, L., Williams, D. R., Wills, L., Wolf, M., Wood, J., Wood, T. R., Woschnagg, K., Wrede, G., D. L., Xu, X. W., Xu, Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Yuan, T., Zöcklein, M., KM3NeT (IHEF, IoP, FNWI), ATLAS (IHEF, IoP, FNWI), IoP (FNWI), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Centre de Physique des Particules de Marseille (CPPM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Informatique et Systèmes (LIS), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Institut méditerranéen d'océanologie (MIO), Centre National de la Recherche Scientifique (CNRS)-Université de Toulon (UTLN)-Aix Marseille Université (AMU)-Institut de Recherche pour le Développement (IRD), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, ANTARES, IceCube, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J.-J., Aublin, J., Baret, B., Basa, S., Belhorma, B., Bertin, V., Biagi, S., Bissinger, M., Boumaaza, J., Bourret, S., Bouta, M., Bouwhuis, M. C., Brânzaş, H., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Celli, S., Chabab, M., Chau, T. N., El Moursli, R. Cherkaoui, Chiarusi, T., Circella, M., Coleiro, A., Colomer, M., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., Díaz, A. F., Wasseige, G. de, Deschamps, A., Distefano, C., Palma, I. Di, Domi, A., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., Bojaddaini, I. El, Khayati, N. El, Elsässer, D., Enzenhöfer, A., Ettahiri, A., Fassi, F., Fermani, P., Ferrara, G., Filippini, F., Fusco, L., Gay, P., Glotin, H., Gozzini, R., Ruiz, R. Gracia, Graf, K., Guidi, C., Hallmann, S., van Haren, H., Heijboer, A. J., Hello, Y., Hernández-Rey, J. J., Hößl, J., Hofestädt, J., Illuminati, G., James, C. W., Jong, M. de, Jong, P. de, Jongen, M., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N. R., Kouchner, A., Kreter, M., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Breton, R. Le, Lefèvre, D., Leonora, E., Levi, G., Lincetto, M., Lopez-Coto, D., Loucatos, S., Maggi, G., Manczak, J., Marcelin, M., Margiotta, A., Marinelli, A., Martínez-Mora, J. A., Mele, R., Melis, K., Migliozzi, P., Moser, M., Moussa, A., Muller, R., Nauta, L., Navas, S., Nezri, E., Nielsen, C., Nuñez-Castiñeyra, A., O’Fearraigh, B., Organokov, M., Păvălaş, G. E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Poirè, C., Popa, V., Pradier, T., Quinn, L., Randazzo, N., Riccobene, G., Sánchez-Losa, A., Salah-Eddine, A., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schüssler, F., Spurio, M., Stolarczyk, Th., Strandberg, B., Taiuti, M., Tayalati, Y., Thakore, T., Tingay, S. J., Trovato, A., Vallage, B., Van Elewyck, V., Versari, F., Viola, S., Vivolo, D., Wilms, J., Zaborov, D., Zegarelli, A., Zornoza, J. D., Zúñiga, J., Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Andeen, K., Anderson, T., Ansseau, I., Argüelles, C., Auffenberg, J., Axani, S., Backes, P., Bagherpour, H., Bai, X., V., A. Balagopal, Barbano, A., Barwick, S. W., Bastian, B., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K.-H., Tjus, J. Becker, BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bohm, C., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Buscher, J., Busse, R. S., Carver, T., Chen, C., Cheung, E., Chirkin, D., Choi, S., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., Clercq, C. De, DeLaunay, J. J., Dembinski, H., Deoskar, K., Ridder, S. De, Desiati, P., Vries, K. D. de, With, M. de, DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dujmovic, H., Dunkman, M., Dvorak, E., Eberhardt, B., Ehrhardt, T., Eller, P., Engel, R., Evenson, P. A., Fahey, S., Fazely, A. R., Felde, J., Filimonov, K., Finley, C., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Ghorbani, K., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Grant, D., Grégoire, T., Griffith, Z., Griswold, S., Günder, M., Gündüz, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hanson, K., Haungs, A., Hebecker, D., Heereman, D., Heix, P., Helbing, K., Hellauer, R., Henningsen, F., Hickford, S., Hignight, J., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jero, K., Jones, B. J. P., Jonske, F., Joppe, R., Kang, D., Kang, W., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Kauer, M., Kelley, J. L., Kheirandish, A., Kim, J., Kintscher, T., Kiryluk, J., Kittler, T., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Krings, K., Krückl, G., Kulacz, N., Kurahashi, N., Kyriacou, A., Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leszczyńska, A., Leuermann, M., Liu, Q. R., Lohfink, E., Lozano Mariscal, C. J., Lu, L., Lucarelli, F., Lünemann, J., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mallik, P., Mallot, K., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., Maunu, R., McNally, F., Meagher, K., Medici, M., Medina, A., Meier, M., Meighen-Berger, S., Merino, G., Meures, T., Micallef, J., Mockler, D., Momenté, G., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Muth, P., Nagai, R., Naumann, U., Neer, G., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Obertacke Pollmann, A., Oehler, M., Olivas, A., O’Murchadha, A., O’Sullivan, E., Palczewski, T., Pandya, H., Pankova, D. V., Park, N., Peiffer, P., de los Heros, C. Pérez, Philippen, S., Pieloth, D., Pieper, S., Pinat, E., Pizzuto, A., Plum, M., Porcelli, A., Price, P. B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rauch, L., Rawlins, K., Rea, I. C., Reimann, R., Relethford, B., Renschler, M., Renzi, G., Resconi, E., Rhode, W., Richman, M., Robertson, S., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Rysewyk, D., Safa, I., Sanchez Herrera, S. E., Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Shefali, S., Silva, M., Snihur, R., Soedingrekso, J., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Strotjohann, N. L., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Terliuk, A., Tilav, S., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Ty, B., Unger, E., Elorrieta, M. A. Unland, Usner, M., Vandenbroucke, J., Van Driessche, W., van Eijk, D., van Eijndhoven, N., van Santen, J., Verpoest, S., Vraeghe, M., Walck, C., Wallace, A., Wallraff, M., Wandkowsky, N., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Wille, L., Williams, D. R., Wills, L., Wolf, M., Wood, J., Wood, T. R., Woschnagg, K., Wrede, G., Xu, D. L., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Yuan, T., Zöcklein, M., Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Toulon (UTLN), Albert, A, Andre, M, Anghinolfi, M, Anton, G, Ardid, M, Aubert, J-J, Aublin, J, Baret, B, Basa, S, Belhorma, B, Bertin, V, Biagi, S, Bissinger, M, Boumaaza, J, Bourret, S, Bouta, M, Bouwhuis, Mc, Branzas, H, Bruijn, R, Brunner, J, Busto, J, Capone, A, Caramete, L, Carr, J, Celli, S, Chabab, M, Chau, Tn, El Moursli, Rc, Chiarusi, T, Circella, M, Coleiro, A, Colomer, M, Coniglione, R, Costantini, H, Coyle, P, Creusot, A, Diaz, Af, de Wasseige, G, Deschamps, A, Distefano, C, Palma, Id, Domi, A, Donzaud, C, Dornic, D, Drouhin, D, Eberl, T, El Bojaddaini, I, Khayati, Ne, Elsasser, D, Enzenhofer, A, Ettahiri, A, Fassi, F, Fermani, P, Ferrara, G, Filippini, F, Fusco, L, Gay, P, Glotin, H, Gozzini, R, Ruiz, Rg, Graf, K, Guidi, C, Hallmann, S, van Haren, H, Heijboer, Aj, Hello, Y, Hernandez-Rey, Jj, Hossl, J, Hofestadt, J, Illuminati, G, James, Cw, de Jong, M, de Jong, P, Jongen, M, Kadler, M, Kalekin, O, Katz, U, Khan-Chowdhury, Nr, Kouchner, A, Kreter, M, Kreykenbohm, I, Kulikovskiy, V, Lahmann, R, Le Breton, R, Lefevre, D, Leonora, E, Levi, G, Lincetto, M, Lopez-Coto, D, Loucatos, S, Maggi, G, Manczak, J, Marcelin, M, Margiotta, A, Marinelli, A, Martinez-Mora, Ja, Mele, R, Melis, K, Migliozzi, P, Moser, M, Moussa, A, Muller, R, Nauta, L, Navas, S, Nezri, E, Nielsen, C, Nunez-Castineyra, A, O'Fearraigh, B, Organokov, M, Pavalas, Ge, Pellegrino, C, Perrin-Terrin, M, Piattelli, P, Poire, C, Popa, V, Pradier, T, Quinn, L, Randazzo, N, Riccobene, G, Sanchez-Losa, A, Salah-Eddine, A, Samtleben, Dfe, Sanguineti, M, Sapienza, P, Schussler, F, Spurio, M, Stolarczyk, T, Strandberg, B, Taiuti, M, Tayalati, Y, Thakore, T, Tingay, Sj, Trovato, A, Vallage, B, Van Elewyck, V, Versari, F, Viola, S, Vivolo, D, Wilms, J, Zaborov, D, Zegarelli, A, Zornoza, Jd, Zuniga, J, Aartsen, Mg, Ackermann, M, Adams, J, Aguilar, Ja, Ahlers, M, Ahrens, M, Alispach, C, Andeen, K, Anderson, T, Ansseau, I, Arguelles, C, Auffenberg, J, Axani, S, Backes, P, Bagherpour, H, Bai, X, Balagopal, Av, Barbano, A, Barwick, Sw, Bastian, B, Baum, V, Baur, S, Bay, R, Beatty, Jj, Becker, K-H, Tjus, Jb, Benzvi, S, Berley, D, Bernardini, E, Besson, Dz, Binder, G, Bindig, D, Blaufuss, E, Blot, S, Bohm, C, Boser, S, Botner, O, Bottcher, J, Bourbeau, E, Bourbeau, J, Bradascio, F, Braun, J, Bron, S, Brostean-Kaiser, J, Burgman, A, Buscher, J, Busse, R, Carver, T, Chen, C, Cheung, E, Chirkin, D, Choi, S, Clark, K, Classen, L, Coleman, A, Collin, Gh, Conrad, Jm, Coppin, P, Correa, P, Cowen, Df, Cross, R, Dave, P, De Clercq, C, Delaunay, Jj, Dembinski, H, Deoskar, K, Ridder, Sd, Desiati, P, de Vries, Kd, With, M, Deyoung, T, Diaz, A, Diaz-Velez, Jc, Dujmovic, H, Dunkman, M, Dvorak, E, Eberhardt, B, Ehrhardt, T, Eller, P, Engel, R, Evenson, Pa, Fahey, S, Fazely, Ar, Felde, J, Filimonov, K, Finley, C, Fox, D, Franckowiak, A, Friedman, E, Fritz, A, Gaisser, Tk, Gallagher, J, Ganster, E, Garrappa, S, Gerhardt, L, Ghorbani, K, Glauch, T, Glusenkamp, T, Goldschmidt, A, Gonzalez, Jg, Grant, D, Gregoire, T, Griffith, Z, Griswold, S, Gunder, M, Gunduz, M, Haack, C, Hallgren, A, Halliday, R, Halve, L, Halzen, F, Hanson, K, Haungs, A, Hebecker, D, Heereman, D, Heix, P, Helbing, K, Hellauer, R, Henningsen, F, Hickford, S, Hignight, J, Hill, Gc, Hoffman, Kd, Hoffmann, R, Hoinka, T, Hokanson-Fasig, B, Hoshina, K, Huang, F, Huber, M, Huber, T, Hultqvist, K, Hunnefeld, M, Hussain, R, In, S, Iovine, N, Ishihara, A, Jansson, M, Japaridze, G, Jeong, M, Jero, K, Jones, Bjp, Jonske, F, Joppe, R, Kang, D, Kang, W, Kappes, A, Kappesser, D, Karg, T, Karl, M, Karle, A, Kauer, M, Kelley, Jl, Kheirandish, A, Kim, J, Kintscher, T, Kiryluk, J, Kittler, T, Klein, Sr, Koirala, R, Kolanoski, H, Kopke, L, Kopper, C, Kopper, S, Koskinen, Dj, Kowalski, M, Krings, K, Kruckl, G, Kulacz, N, Kurahashi, N, Kyriacou, A, Lanfranchi, Jl, Larson, Mj, Lauber, F, Lazar, Jp, Leonard, K, Leszczynska, A, Leuermann, M, Liu, Qr, Lohfink, E, Mariscal, Cjl, Lu, L, Lucarelli, F, Lunemann, J, Luszczak, W, Lyu, Y, Ma, Wy, Madsen, J, Mahn, Kbm, Makino, Y, Mallik, P, Mallot, K, Mancina, S, Maris, Ic, Maruyama, R, Mase, K, Maunu, R, Mcnally, F, Meagher, K, Medici, M, Medina, A, Meier, M, Meighen-Berger, S, Merino, G, Meures, T, Micallef, J, Mockler, D, Momente, G, Montaruli, T, Moore, Rw, Morse, R, Moulai, M, Muth, P, Nagai, R, Naumann, U, Neer, G, Niederhausen, H, Nisa, Mu, Nowicki, Sc, Nygren, Dr, Pollmann, Ao, Oehler, M, Olivas, A, O'Murchadha, A, O'Sullivan, E, Palczewski, T, Pandya, H, Pankova, Dv, Park, N, Peiffer, P, de los Heros, Cp, Philippen, S, Pieloth, D, Pieper, S, Pinat, E, Pizzuto, A, Plum, M, Porcelli, A, Price, Pb, Przybylski, Gt, Raab, C, Raissi, A, Rameez, M, Rauch, L, Rawlins, K, Rea, Ic, Reimann, R, Relethford, B, Renschler, M, Renzi, G, Resconi, E, Rhode, W, Richman, M, Robertson, S, Rongen, M, Rott, C, Ruhe, T, Ryckbosch, D, Rysewyk, D, Safa, I, Herrera, Se, Sandrock, A, Sandroos, J, Santander, M, Sarkar, S, Satalecka, K, Schaufel, M, Schieler, H, Schlunder, P, Schmidt, T, Schneider, A, Schneider, J, Schroder, Fg, Schumacher, L, Sclafani, S, Seckel, D, Seunarine, S, Shefali, S, Silva, M, Snihur, R, Soedingrekso, J, Soldin, D, Song, M, Spiczak, Gm, Spiering, C, Stachurska, J, Stamatikos, M, Stanev, T, Stein, R, Stettner, J, Steuer, A, Stezelberger, T, Stokstad, Rg, Stosssl, A, Strotjohann, Nl, Sturwald, T, Stuttard, T, Sullivan, Gw, Taboada, I, Tenholt, F, Ter-Antonyan, S, Terliuk, A, Tilav, S, Tollefson, K, Tomankova, L, Tonnis, C, Toscano, S, Tosi, D, Trettin, A, Tselengidou, M, Tung, Cf, Turcati, A, Turcotte, R, Turley, Cf, Ty, B, Unger, E, Elorrieta, Mau, Usner, M, Vandenbroucke, J, Van Driessche, W, van Eijk, D, van Eijndhoven, N, van Santen, J, Verpoest, S, Vraeghe, M, Walck, C, Wallace, A, Wallraff, M, Wandkowsky, N, Watson, Tb, Weaver, C, Weindl, A, Weiss, Mj, Weldert, J, Wendt, C, Werthebach, J, Whelan, Bj, Whitehorn, N, Wiebe, K, Wiebusch, Ch, Wille, L, Williams, Dr, Wills, L, Wolf, M, Wood, J, Wood, Tr, Woschnagg, K, Wrede, G, Xu, Dl, Xu, Xw, Xu, Y, Yanez, Jp, Yodh, G, Yoshida, S, Yuan, T, Zocklein, M, Centre Tecnològic de Vilanova i la Geltrú, Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques, Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Physics, Faculty of Sciences and Bioengineering Sciences, Vriendenkring VUB, Elementary Particle Physics, Andre, M., Aubert, J. -J., Branzas, H., El Moursli, R. C., Diaz, A. F., Wasseige, G. D., Palma, I. D., Bojaddaini, I. E., Khayati, N. E., Elsasser, D., Enzenhofer, A., Ruiz, R. G., Van Haren, H., Hernandez-Rey, J. J., Hossl, J., Hofestadt, J., Jong, M. D., Jong, P. D., Breton, R. L., Lefevre, D., Martinez-Mora, J. A., Nuez-Castieyra, A., O'Fearraigh, B., Pavalas, G. E., Poire, C., Sanchez-Losa, A., Schussler, F., Stolarczyk, T., Zuiga, J., Arguelles, C., V. A., B., Becker, K. -H., Tjus, J. B., Benzvi, S., Boser, S., Bottcher, J., Clercq, C. D., Delaunay, J. J., Ridder, S. D., Vries, K. D. D., With, M. D., Deyoung, T., Diaz-Velez, J. C., Glusenkamp, T., Gregoire, T., Gunder, M., Gunduz, M., Hunnefeld, M., Kopke, L., Kruckl, G., Leszczynska, A., Lunemann, J., Maris, I. C., Mcnally, F., Momente, G., O'Murchadha, A., O'Sullivan, E., De Los Heros, C. P., Schroder, F. G., Stossl, A., Sturwald, T., Tonnis, C., Elorrieta, M. A. U., Van Eijk, D., Van Eijndhoven, N., Van Santen, J., and Zocklein, M.
Subjects: Astrofísica, 010504 meteorology & atmospheric sciences, Science and engineering, 01 natural sciences, Point like and extended sources, IceCube, particle source [neutrino], High-throughput computing, detector [neutrino], 010303 astronomy & astrophysics, High Energy Astrophysical Phenomena (astro-ph.HE), astro-ph.HE, Physics, Astrophysics::Instrumentation and Methods for Astrophysics, neutrinos, astrophysical neutrinos, neutrino telescopes, GAMMA RAY EMISSION, COSMIC RAYS, COSMIC-RAYS, neutrino: detector, Neutrino astronomy, Science policy, Engineering research, Astrophysics - High Energy Astrophysical Phenomena, Antares neutrino telescope, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Library science, 0103 physical sciences, supernova, Neutrins, Neutrinos, Astrophysics::Galaxy Astrophysics, 0105 earth and related environmental sciences, Astroparticle physics, IceCube neutrino telescope, ANTARES, Telescopis, Astronomy and Astrophysics, DESY, neutrino: particle source, sensitivity, Neutrino astrophysics, Computing center, flux, Physics and Astronomy, 13. Climate action, Space and Planetary Science, Research council, FISICA APLICADA, Física::Astronomia i astrofísica [Àrees temàtiques de la UPC], ddc:520, galaxy, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], GAMMA-RAY EMISSION, Telescopes
Abstract: [EN] A search for point-like and extended sources of cosmic neutrinos using data collected by the ANTARES and IceCube neutrino telescopes is presented. The data set consists of all the track-like and shower-like events pointing in the direction of the Southern Sky included in the nine-year ANTARES point-source analysis, combined with the throughgoing track-like events used in the seven-year IceCube point-source search. The advantageous ¿eld of view of ANTARES and the large size of IceCube are exploited to improve the sensitivity in the Southern Sky by a factor of ~2 compared to both individual analyses. In this work, the Southern Sky is scanned for possible excesses of spatial clustering, and the positions of preselected candidate sources are investigated. In addition, special focus is given to the region around the Galactic Center, whereby a dedicated search at the location of SgrA* is performed, and to the location of the supernova remnant RXJ 1713.7-3946. No signi¿cant evidence for cosmic neutrino sources is found, and upper limits on the ¿ux from the various searches are presented., The authors of the IceCube Collaboration acknowledge the support from the following agencies and institutions: USA-U.S. National Science Foundation-Office of Polar Programs, U.S. National Science Foundation-Physics Division, Wisconsin Alumni Research Foundation, Center for High Throughput Computing (CHTC) at the University of Wisconsin-Madison, Open Science Grid (OSG), Extreme Science and Engineering Discovery Environment (XSEDE), U.S. Department of Energy-National Energy Research Scientific Computing Center, Particle astrophysics research computing center at the University of Maryland, Institute for Cyber-Enabled Research at Michigan State University, and Astroparticle physics computational facility at Marquette University; Belgium-Funds for Scientific Research (FRS-FNRS and FWO), FWO Odysseus and Big Science programmes, and Belgian Federal Science Policy Office (Belspo); Germany-Bundesministerium fur Bildung und Forschung (BMBF), Deutsche Forschungsgemeinschaft (DFG), Helmholtz Alliance for Astroparticle Physics (HAP), Initiative and Networking Fund of the Helmholtz Association, Deutsches Elektronen Synchrotron (DESY), and High Performance Computing Cluster of the RWTH Aachen; Sweden-Swedish Research Council, Swedish Polar Research Secretariat, Swedish National Infrastructure for Computing (SNIC), and Knut and Alice Wallenberg Foundation; Australia - Australian Research Council; Canada-Natural Sciences and Engineering Research Council of Canada, Calcul Quebec, Compute Ontario, Canada Foundation for Innovation, WestGrid, and Compute Canada; Denmark-Villum Fonden, Danish National Research Foundation (DNRF), Carlsberg Foundation; New Zealand-Marsden Fund; Japan-Japan Society for Promotion of Science (JSPS) and Institute for Global Prominent Research (IGPR) of Chiba University; Korea-National Research Foundation of Korea (NRF); Switzerland-Swiss National Science Foundation (SNSF); United Kingdom-Department of Physics, University of Oxford.
Published: 2020

15. Search for neutrino counterparts of gravitational-wave events detected by LIGO and Virgo during run O2 with the ANTARES telescope

Author: ANTARES Collaboration, Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J. J., Aublin, J., Baret, B., Basa, S., Belhorma, B., Bertin, V., Biagi, S., Bissinger, M., Boumaaza, J., Bouta, M., Bouwhuis, M. C., Brânzaş, H., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Celli, S., Chabab, M., Chau, T. N., Moursli, R. Cherkaoui El, Chiarusi, T., Circella, M., Coleiro, A., Colomer-Molla, M., Coniglione, R., Coyle, P., Creusot, A., Díaz, A. F., de Wasseige, G., Deschamps, A., Distefano, C., Di Palma, I., Domi, A., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., Khayati, N. El, Enzenhöfer, A., Ettahiri, A., Fermani, P., Ferrara, G., Filippini, F., Fusco, L., Gay, P., Glotin, H., Gozzini, R., Ruiz, R. Gracia, Graf, K., Guidi, C., Hallmann, S., van Haren, H., Heijboer, A. J., Hello, Y., Hernández-Rey, J. J., Hößl, J., Hofestädt, J., Huang, F., Illuminati, G., James, C. W., de Jong, M., de Jong, P., Jongen, M., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N. R., Kouchner, A., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Breton, R. Le, Lefèvre, D., Leonora, E., Levi, G., Lincetto, M., Lopez-Coto, D., Loucatos, S., Maggi, G., Manczak, J., Marcelin, M., Margiotta, A., Marinelli, A., Martínez-Mora, J. A., Mele, R., Melis, K., Migliozzi, P., Moser, M., Moussa, A., Muller, R., Nauta, L., Navas, S., Nezri, E., Nielsen, C., Nuñez-Castiñeyra, A., O'Fearraigh, B., Organokov, M., Păvălaş, G. E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Poirè, C., Popa, V., Pradier, T., Randazzo, N., Reck, S., Riccobene, G., Sánchez-Losa, A., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schüssler, F., Spurio, M., Stolarczyk, Th., Strandberg, B., Taiuti, M., Tayalati, Y., Thakore, T., Tingay, S. J., Trovato, A., Vallage, B., Van Elewyck, V., Versari, F., Viola, S., Vivolo, D., Wilms, J., Zaborov, D., Zegarelli, A., Zornoza, J. D., Zúñiga, J., Institut Pluridisciplinaire Hubert Curien (IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Laboratoire d'Informatique et Systèmes (LIS), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Institut méditerranéen d'océanologie (MIO), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, ANTARES, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), ANR-18-IDEX-0001,Université de Paris,Université de Paris(2018), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Toulon (UTLN), Albert, A, Andre, M, Anghinolfi, M, Anton, G, Ardid, M, Aubert, Jj, Aublin, J, Baret, B, Basa, S, Belhorma, B, Bertin, V, Biagi, S, Bissinger, M, Boumaaza, J, Bouta, M, Bouwhuis, Mc, Branzas, H, Bruijn, R, Brunner, J, Busto, J, Capone, A, Caramete, L, Carr, J, Celli, S, Chabab, M, Chau, Tn, El Moursli, Rc, Chiarusi, T, Circella, M, Coleiro, A, Colomer-Molla, M, Coniglione, R, Coyle, P, Creusot, A, Diaz, Af, de Wasseige, G, Deschamps, A, Distefano, C, Di Palma, I, Domi, A, Donzaud, C, Dornic, D, Drouhin, D, Eberl, T, El Khayati, N, Enzenhofer, A, Ettahiri, A, Fermani, P, Ferrara, G, Filippini, F, Fusco, L, Gay, P, Glotin, H, Gozzini, R, Ruiz, Rg, Graf, K, Guidi, C, Hallmann, S, van Haren, H, Heijboer, Aj, Hello, Y, Hernandez-Rey, Jj, Hoessl, J, Hofestadt, J, Huang, F, Illuminati, G, James, Cw, de Jong, M, de Jong, P, Jongen, M, Kadler, M, Kalekin, O, Katz, U, Khan-Chowdhury, Nr, Kouchner, A, Kreykenbohm, I, Kulikovskiy, V, Lahmann, R, Le Breton, R, Lefevre, D, Leonora, E, Levi, G, Lincetto, M, Lopez-Coto, D, Loucatos, S, Maggi, G, Manczak, J, Marcelin, M, Margiotta, A, Marinelli, A, Martinez-Mora, Ja, Mele, R, Melis, K, Migliozzi, P, Moser, M, Moussa, A, Muller, R, Nauta, L, Navas, S, Nezri, E, Nielsen, C, Nunez-Castineyra, A, O'Fearraigh, B, Organokov, M, Pavalas, Ge, Pellegrino, C, Perrin-Terrin, M, Piattelli, P, Poire, C, Popa, V, Pradier, T, Randazzo, N, Reck, S, Riccobene, G, Sanchez-Losa, A, Samtleben, Dfe, Sanguineti, M, Sapienza, P, Schussler, F, Spurio, M, Stolarczyk, T, Strandberg, B, Taiuti, M, Tayalati, Y, Thakore, T, Tingay, Sj, Trovato, A, Vallage, B, Van Elewyck, V, Versari, F, Viola, S, Vivolo, D, Wilms, J, Zaborov, D, Zegarelli, A, Zornoza, Jd, Zuniga, J, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Albert A., Andre M., Anghinolfi M., Anton G., Ardid M., Aubert J.-J., Aublin J., Baret B., Basa S., Belhorma B., Bertin V., Biagi S., Bissinger M., Boumaaza J., Bouta M., Bouwhuis M.C., Branzas H., Bruijn R., Brunner J., Busto J., Capone A., Caramete L., Carr J., Celli S., Chabab M., Chau T.N., Moursli R.C.E., Chiarusi T., Circella M., Coleiro A., Molla M.C., Coniglione R., Coyle P., Creusot A., Diaz A.F., de Wasseige G., Deschamps A., Distefano C., Palma I.D., Domi A., Donzaud C., Dornic D., Drouhin D., Eberl T., Khayati N.E., Enzenhofer A., Ettahiri A., Fermani P., Ferrara G., Filippini F., Fusco L., Gay P., Glotin H., Gozzini R., Ruiz R.G., Graf K., Guidi C., Hallmann S., van Haren H., Heijboer A.J., Hello Y., Hernandez-Rey J.J., Hossl J., Hofestadt J., Huang F., Illuminati G., James C.W., de Jong M., de Jong P., Jongen M., Kadler M., Kalekin O., Katz U., Khan-Chowdhury N.R., Kouchner A., Kreykenbohm I., Kulikovskiy V., Lahmann R., Le Breton R., Lefevre D., Leonora E., Levi G., Lincetto M., Lopez-Coto D., Loucatos S., Maggi G., Manczak J., Marcelin M., Margiotta A., Marinelli A., Martinez-Mora J.A., Mele R., Melis K., Migliozzi P., Moser M., Moussa A., Muller R., Nauta L., Navas S., Nezri E., Nielsen C., Nunez-Castineyra A., O'Fearraigh B., Organokov M., Pavalas G.E., Pellegrino C., Perrin-Terrin M., Piattelli P., Poire C., Popa V., Pradier T., Randazzo N., Reck S., Riccobene G., Sanchez-Losa A., Samtleben D.F.E., Sanguineti M., Sapienza P., Schussler F., Spurio M., Stolarczyk T., Strandberg B., Taiuti M., Tayalati Y., Thakore T., Tingay S.J., Trovato A., Vallage B., Van Elewyck V., Versari F., Viola S., Vivolo D., Wilms J., Zaborov D., Zegarelli A., Zornoza J.D., Zuniga J., Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Centre Tecnològic de Vilanova i la Geltrú, Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA), KM3NeT (IHEF, IoP, FNWI), ATLAS (IHEF, IoP, FNWI), IoP (FNWI), Albert, A., Andre, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J. -J., Aublin, J., Baret, B., Basa, S., Belhorma, B., Bertin, V., Biagi, S., Bissinger, M., Boumaaza, J., Bouta, M., Bouwhuis, M. C., Branzas, H., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Celli, S., Chabab, M., Chau, T. N., Moursli, R. C. E., Chiarusi, T., Circella, M., Coleiro, A., Molla, M. C., Coniglione, R., Coyle, P., Creusot, A., Diaz, A. F., de Wasseige, G., Deschamps, A., Distefano, C., Palma, I. D., Domi, A., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., Khayati, N. E., Enzenhofer, A., Ettahiri, A., Fermani, P., Ferrara, G., Filippini, F., Fusco, L., Gay, P., Glotin, H., Gozzini, R., Ruiz, R. G., Graf, K., Guidi, C., Hallmann, S., van Haren, H., Heijboer, A. J., Hello, Y., Hernandez-Rey, J. J., Hossl, J., Hofestadt, J., Huang, F., Illuminati, G., James, C. W., de Jong, M., de Jong, P., Jongen, M., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N. R., Kouchner, A., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Le Breton, R., Lefevre, D., Leonora, E., Levi, G., Lincetto, M., Lopez-Coto, D., Loucatos, S., Maggi, G., Manczak, J., Marcelin, M., Margiotta, A., Marinelli, A., Martinez-Mora, J. A., Mele, R., Melis, K., Migliozzi, P., Moser, M., Moussa, A., Muller, R., Nauta, L., Navas, S., Nezri, E., Nielsen, C., Nunez-Castineyra, A., O'Fearraigh, B., Organokov, M., Pavalas, G. E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Poire, C., Popa, V., Pradier, T., Randazzo, N., Reck, S., Riccobene, G., Sanchez-Losa, A., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schussler, F., Spurio, M., Stolarczyk, T., Strandberg, B., Taiuti, M., Tayalati, Y., Thakore, T., Tingay, S. J., Trovato, A., Vallage, B., Van Elewyck, V., Versari, F., Viola, S., Vivolo, D., Wilms, J., Zaborov, D., Zegarelli, A., Zornoza, J. D., and Zuniga, J.
Subjects: Astrofísica, Physics and Astronomy (miscellaneous), neutrino astronomy, ANATARES telescope, Physics::Instrumentation and Detectors, Astrophysics, 01 natural sciences, Coincidence, High Energy Physics - Experiment, law.invention, High Energy Physics - Experiment (hep-ex), neutrino, law, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], LIGO, 010303 astronomy & astrophysics, Charged current, media_common, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, 4. Education, Astrophysics::Instrumentation and Methods for Astrophysics, neutrino telescopes, astroparticle physics, gravitational waves, Physique [physics]/Astrophysique [astro-ph], Neutrino, Astrophysics - High Energy Astrophysical Phenomena, Antares neutrino telescope, media_common.quotation_subject, Astrophysics::High Energy Astrophysical Phenomena, Run O2, FOS: Physical sciences, lcsh:Astrophysics, Gravitational waves, Telescope, Ones gravitacionals, lcsh:QB460-466, 0103 physical sciences, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, Neutrins, Engineering (miscellaneous), 010308 nuclear & particles physics, Gravitational wave, Horizon, High Energy Physics::Phenomenology, gravitational radiation, Electromagnetic fields, Physique [physics]/Physique des Hautes Energies - Expérience [hep-ex], Gravitational-wave, Neutrino, gravitational-wave, ANTARES, VIRGO, Sky, FISICA APLICADA, Física::Astronomia i astrofísica [Àrees temàtiques de la UPC], lcsh:QC770-798, High Energy Physics::Experiment, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: An offline search for a neutrino counterpart to gravitational-wave (GW) events detected during the second observation run (O2) of Advanced-LIGO and Advanced- Virgo performed with ANTARES data is presented. In addition to the search for long tracks induced by νμ (νμ) charged current interactions, a search for showering events induced by interactions of neutrinos of any flavour is conducted. The severe spatial and time coincidence provided by the gravitational-wave alert allows regions above the detector horizon to be probed, extending the ANTARES sensitivity over the entire sky. The results of this all-neutrino-flavour and all-sky time dependent analysis are presented. The search for prompt neutrino emission within ±500 s around the time of six GW events yields no neutrino counterparts. Upper limits on the neutrino spectral fluence and constraints on the isotropic energy radiated via high-energy neutrinos (from a few TeV to a few tens of PeV) are set for each GW event analysed., Centre National de la Recherche Scientifique (CNRS), French Atomic Energy Commission, Commission Europeenne (FEDER fund), France, European Union (EU), Institut Universitaire de France (IUF), France, LabEx UnivEarthS, France ANR-10-LABX-0023 ANR-18-IDEX-0001, Region Ile-de-France, Region Grand-Est, Region Provence-Alpes-Cote d'Azur, Ville de La Seyne-sur-Mer, France, Federal Ministry of Education & Research (BMBF), Istituto Nazionale di Fisica Nucleare (INFN), Netherlands Organization for Scientific Research (NWO) Netherlands Government, Council of the President of the Russian Federation for young scientists and leading scientific schools supporting grants, Russia, Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI), Romania, Ministerio de Ciencia, Innovación, Investigación y Universidades (MCIU): Programa Estatal de Generación de Conocimiento, Spain PGC2018-096663-B-C41 PGC2018-096663-A-C42 PGC2018-096663-B-C43 PGC2018-096663-B-C44, Severo Ochoa Centre of Excellence and MultiDark Consolider (MCIU), Junta de Andalucía, Spain SOMM17/6104/UGR, Generalitat Valenciana: Grisolia, Spain GRISOLIA/2018/119, Ministry of Higher Education, Scientific Research and Professional Training, Morocco
Published: 2020

16. Search for dark matter towards the Galactic Centre with 11 years of ANTARES data

Author: Albert, A., André, M., Anghinolfi, M., Ardid, M., Aubert, J. -J., Aublin, J., Baret, B., Basa, S., Belhorma, B., Bertin, V., Biagi, S., Bissinger, M., Boumaaza, J., Bouta, M., Bouwhuis, M. C., Brânzaş, H., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Celli, S., Chabab, M., Chau, T. N., Cherkaoui El Moursli, R., Chiarusi, T., Circella, M., Coleiro, A., Colomer, M., Coniglione, R., Coyle, P., Creusot, A., Díaz, A. F., Deschamps, A., Distefano, C., Di Palma, I., Domi, A., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., El Khayati, N., Enzenhöfer, A., Ettahiri, A., Fermani, P., Ferrara, G., Filippini, F., Fusco, L., Gay, P., Glotin, H., Gozzini, R., Gracia Ruiz, R., Graf, K., Guidi, C., Hallmann, S., van Haren, H., Heijboer, A. J., Hello, Y., Hernández-Rey, J. J., Hößl, J., Hofestädt, J., Huang, F., Illuminati, G., James, C. W., de Jong, M., de Jong, P., Jongen, M., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N. R., Kouchner, A., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Le Breton, R., Lefèvre, D., Leonora, E., Levi, G., Lincetto, M., Lopez-Coto, D., Loucatos, S., Maggi, G., Manczak, J., Marcelin, M., Margiotta, A., Marinelli, A., Martínez-Mora, J. A., Mele, R., Melis, K., Migliozzi, P., Moser, M., Moussa, A., Muller, R., Nauta, L., Navas, S., Nezri, E., Nielsen, C., Nuñez-Castiñeyra, A., O'Fearraigh, B., Organokov, M., Păvălaş, G. E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Poirè, C., Popa, V., Pradier, T., Randazzo, N., Reck, S., Riccobene, G., Sánchez-Losa, A., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schüssler, F., Spurio, M., Stolarczyk, Th., Strandberg, B., Taiuti, M., Tayalati, Y., Thakore, T., Tingay, S. J., Trovato, A., Vallage, B., Van Elewyck, V., Versari, F., Viola, S., Vivolo, D., Wilms, J., Zaborov, D., Zegarelli, A., Zornoza, J. D., Zúñiga, J., Aartsen, IceCube Collaboration: M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Auffenberg, J., Axani, S., Bagherpour, H., Bai, X., A. Balagopal V., Barbano, A., Barwick, S. W., Bastian, B., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Becker Tjus, J., Benzvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bohm, C., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Buscher, J., Busse, R. S., Carver, T., Chen, C., Cheung, E., Chirkin, D., Choi, S., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., De Clercq, C., Delaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., Deyoung, T., Diaz, A., Díaz-Vélez, J. C., Dujmovic, H., Dunkman, M., Dvorak, E., Eberhardt, B., Ehrhardt, T., Eller, P., Engel, R., Evenson, P. A., Fahey, S., Fazely, A. R., Felde, J., Filimonov, K., Finley, C., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Ghorbani, K., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Grant, D., Grégoire, T., Griffith, Z., Griswold, S., Günder, M., Gündüz, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hanson, K., Haungs, A., Hebecker, D., Heereman, D., Heix, P., Helbing, K., Hellauer, R., Henningsen, F., Hickford, S., Hignight, J., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jero, K., Jones, B. J. P., Jonske, F., Joppe, R., Kang, D., Kang, W., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kim, J., Kintscher, T., Kiryluk, J., Kittler, T., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Krings, K., Krückl, G., Kulacz, N., Kurahashi, N., Kyriacou, A., Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leszczyńska, A., Liu, Q. R., Lohfink, E., Lozano Mariscal, C. J., Lu, L., Lucarelli, F., Ludwig, A., Lünemann, J., Luszczak, W., Lyu, Y., W. Y., Ma, Madsen, J., Mahn, K. B. M., Makino, Y., Mallik, P., Mallot, K., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., Maunu, R., Mcnally, F., Meagher, K., Medici, M., Medina, A., Meier, M., Meighen-Berger, S., Merino, G., Meures, T., Micallef, J., Mockler, D., Momenté, G., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Muth, P., Nagai, R., Naumann, U., Neer, G., Nguyen, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Obertacke Pollmann, A., Oehler, M., Olivas, A., O'Murchadha, A., O'Sullivan, E., Palczewski, T., Pandya, H., Pankova, D. V., Park, N., Peiffer, P., Pérez de los Heros, C., Philippen, S., Pieloth, D., Pieper, S., Pinat, E., Pizzuto, A., Plum, M., Porcelli, A., Price, P. B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rauch, L., Rawlins, K., Rea, I. C., Rehman, A., Reimann, R., Relethford, B., Renschler, M., Renzi, G., Resconi, E., Rhode, W., Richman, M., Robertson, S., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Rysewyk Cantu, D., Safa, I., Sanchez Herrera, S. E., Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Shefali, S., Silva, M., Snihur, R., Soedingrekso, J., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Stös(s)l, A., Strotjohann, N. L., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Terliuk, A., Tilav, S., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Ty, B., Unger, E., Unland Elorrieta, M. A., Usner, M., Vandenbroucke, J., Van Driessche, W., van Eijk, D., van Eijndhoven, N., van Santen, J., Verpoest, S., Vraeghe, M., Walck, C., Wallace, A., Wallraff, M., Wandkowsky, N., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Wille, L., Williams, D. R., Wills, L., Wolf, M., Wood, J., Wood, T. R., Woschnagg, K., Wrede, G., Wulff, J., D. L., Xu, X. W., Xu, Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Yuan, T., Zöcklein, M., Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Institut méditerranéen d'océanologie (MIO), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Université de Toulon - UFR Sciences et Techniques (UTLN UFR ScT), Université de Toulon (UTLN), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, ANTARES, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Albert A., Andre M., Anghinolfi M., Anton G., Ardid M., Aubert J.-J., Aublin J., Baret B., Basa S., Belhorma B., Bertin V., Biagi S., Bissinger M., Boumaaza J., Bourret S., Bouta M., Bouwhuis M.C., Branzas H., Bruijn R., Brunner J., Busto J., Capone A., Caramete L., Carr J., Celli S., Chabab M., Chau T.N., Cherkaoui El Moursli R., Chiarusi T., Circella M., Coleiro A., Colomer M., Coniglione R., Costantini H., Coyle P., Creusot A., Diaz A.F., de Wasseige G., Deschamps A., Distefano C., Di Palma I., Domi A., Donzaud C., Dornic D., Drouhin D., Eberl T., El Bojaddaini I., El Khayati N., Elsasser D., Enzenhofer A., Ettahiri A., Fassi F., Fermani P., Ferrara G., Filippini F., Fusco L., Gay P., Glotin H., Gozzini R., Gracia Ruiz R., Graf K., Guidi C., Hallmann S., van Haren H., Heijboer A.J., Hello Y., Hernandez-Rey J.J., Hossl J., Hofestadt J., Illuminati G., James C.W., de Jong M., de Jong P., Jongen M., Kadler M., Kalekin O., Katz U., Khan-Chowdhury N.R., Kouchner A., Kreter M., Kreykenbohm I., Kulikovskiy V., Lahmann R., Le Breton R., Lefevre D., Leonora E., Levi G., Lincetto M., Lopez-Coto D., Loucatos S., Maggi G., Manczak J., Marcelin M., Margiotta A., Marinelli A., Martinez-Mora J.A., Mele R., Melis K., Migliozzi P., Moser M., Moussa A., Muller R., Nauta L., Navas S., Nezri E., Nielsen C., Nunez-Castineyra A., O'Fearraigh B., Organokov M., Pavalas G.E., Pellegrino C., Perrin-Terrin M., Piattelli P., Poire C., Popa V., Pradier T., Quinn L., Randazzo N., Riccobene G., Sanchez-Losa A., Salah-Eddine A., Samtleben D.F.E., Sanguineti M., Sapienza P., Schussler F., Spurio M., Stolarczyk T., Strandberg B., Taiuti M., Tayalati Y., Thakore T., Tingay S.J., Trovato A., Vallage B., Van Elewyck V., Versari F., Viola S., Vivolo D., Wilms J., Zaborov D., Zegarelli A., Zornoza J.D., Zuniga J., KM3NeT (IHEF, IoP, FNWI), ATLAS (IHEF, IoP, FNWI), Albert, A, Andre, M, Anghinolfi, M, Anton, G, Ardid, M, Aubert, Jj, Aublin, J, Baret, B, Basa, S, Belhorma, B, Bertin, V, Biagi, S, Bissinger, M, Boumaaza, J, Bourret, S, Bouta, M, Bouwhuis, Mc, Branzas, H, Bruijn, R, Brunner, J, Busto, J, Capone, A, Caramete, L, Carr, J, Celli, S, Chabab, M, Chau, Tn, El Moursli, Rc, Chiarusi, T, Circella, M, Coleiro, A, Colomer, M, Coniglione, R, Costantini, H, Coyle, P, Creusot, A, Diaz, Af, de Wasseige, G, Deschamps, A, Distefano, C, Di Palma, I, Domi, A, Donzaud, C, Dornic, D, Drouhin, D, Eberl, T, El Bojaddaini, I, El Khayati, N, Elsasser, D, Enzenhofer, A, Ettahiri, A, Fassi, F, Fermani, P, Ferrara, G, Filippini, F, Fusco, L, Gay, P, Glotin, H, Gozzini, R, Ruiz, Rg, Graf, K, Guidi, C, Hallmann, S, van Haren, H, Heijboer, Aj, Hello, Y, Hernandez-Rey, Jj, Hossl, J, Hofestadt, J, Illuminati, G, Jamesa, Cw, de Jong, M, de Jong, P, Jongen, M, Kadler, M, Kalekin, O, Katz, U, Khan-Chowdhury, Nr, Kouchner, A, Kreter, M, Kreykenbohm, I, Kulikovskiy, V, Lahmann, R, Le Breton, R, Lefevre, D, Leonora, E, Levi, G, Lincetto, M, Lopez-Coto, D, Loucatos, S, Maggi, G, Manczak, J, Marcelin, M, Margiotta, A, Marinelli, A, Martinez-Mora, Ja, Mele, R, Melis, K, Migliozzi, P, Moser, M, Moussa, A, Muller, R, Nauta, L, Navas, S, Nezri, E, Nielsen, C, Nunez-Castineyra, A, O'Fearraigh, B, Organokov, M, Pavalas, Ge, Pellegrino, C, Perrin-Terrin, M, Piattelli, P, Poire, C, Popa, V, Pradier, T, Quinn, L, Randazzoa, N, Riccobene, G, Sanchez-Losa, A, Salah-Eddine, A, Samtleben, Dfe, Sanguineti, M, Sapienza, P, Schussler, F, Spurio, M, Stolarczyk, T, Strandberg, B, Taiuti, M, Tayalati, Y, Thakore, T, Tingay, Sj, Trovato, A, Vallage, B, Van Elewyck, V, Versari, F, Viola, S, Vivolo, D, Wilms, J, Zaborov, D, Zegarelli, A, Zornoza, Jd, Zuniga, J, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia e Innovación (España), Generalitat Valenciana, Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Toulon (UTLN)-Aix Marseille Université (AMU)-Institut de Recherche pour le Développement (IRD), Centre Tecnològic de Vilanova i la Geltrú, Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques, Albert, A., Andre, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J. -J., Aublin, J., Baret, B., Basa, S., Belhorma, B., Bertin, V., Biagi, S., Bissinger, M., Boumaaza, J., Bourret, S., Bouta, M., Bouwhuis, M. C., Branzas, H., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Celli, S., Chabab, M., Chau, T. N., Cherkaoui El Moursli, R., Chiarusi, T., Circella, M., Coleiro, A., Colomer, M., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., Diaz, A. F., de Wasseige, G., Deschamps, A., Distefano, C., Di Palma, I., Domi, A., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., El Bojaddaini, I., El Khayati, N., Elsasser, D., Enzenhofer, A., Ettahiri, A., Fassi, F., Fermani, P., Ferrara, G., Filippini, F., Fusco, L., Gay, P., Glotin, H., Gozzini, R., Gracia Ruiz, R., Graf, K., Guidi, C., Hallmann, S., van Haren, H., Heijboer, A. J., Hello, Y., Hernandez-Rey, J. J., Hossl, J., Hofestadt, J., Illuminati, G., James, C. W., de Jong, M., de Jong, P., Jongen, M., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N. R., Kouchner, A., Kreter, M., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Le Breton, R., Lefevre, D., Leonora, E., Levi, G., Lincetto, M., Lopez-Coto, D., Loucatos, S., Maggi, G., Manczak, J., Marcelin, M., Margiotta, A., Marinelli, A., Martinez-Mora, J. A., Mele, R., Melis, K., Migliozzi, P., Moser, M., Moussa, A., Muller, R., Nauta, L., Navas, S., Nezri, E., Nielsen, C., Nunez-Castineyra, A., O'Fearraigh, B., Organokov, M., Pavalas, G. E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Poire, C., Popa, V., Pradier, T., Quinn, L., Randazzo, N., Riccobene, G., Sanchez-Losa, A., Salah-Eddine, A., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schussler, F., Spurio, M., Stolarczyk, T., Strandberg, B., Taiuti, M., Tayalati, Y., Thakore, T., Tingay, S. J., Trovato, A., Vallage, B., Van Elewyck, V., Versari, F., Viola, S., Vivolo, D., Wilms, J., Zaborov, D., Zegarelli, A., Zornoza, J. D., and Zuniga, J.
Subjects: ANTARES, Dark matter indirect detection, Galactic Centre, Neutrino telescope, Astrofísica, Physics::Instrumentation and Detectors, neutrino: energy: high, astro-ph.HE, Astrophysics, 01 natural sciences, neutrino: flux, WIMP, S046PHB, hal-02431461, detector [neutrino], Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Annihilation, 4. Education, Astrophysics::Instrumentation and Methods for Astrophysics, dark matter: density: high, lcsh:QC1-999, neutrino: detector, Neutrino detector, density: high [dark matter], annihilation, Dark matter, indirect detection, Weakly interacting massive particles, Neutrino, Astrophysics - High Energy Astrophysical Phenomena, Nuclear and High Energy Physics, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, Partícules (Física nuclear), Standard Model, S030DMA, 0103 physical sciences, Neutrins, 010306 general physics, Particles (Nuclear physics), Telescopis, 010308 nuclear & particles physics, Galaxy, Automatic Keywords, FISICA APLICADA, Física::Astronomia i astrofísica [Àrees temàtiques de la UPC], spectral, High Energy Physics::Experiment, galaxy, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], lcsh:Physics, Telescopes
Abstract: Neutrino detectors participate in the indirect search for the fundamental constituents of dark matter (DM) in form of weakly interacting massive particles (WIMPs). In WIMP scenarios, candidate DM particles can pair-annihilate into Standard Model products, yielding considerable fluxes of high-energy neutrinos. A detector like ANTARES, located in the Northern Hemisphere, is able to perform a complementary search looking towards the Galactic Centre, where a high density of dark matter is thought to accumulate. Both this directional information and the spectral features of annihilating DM pairs are entered into an unbinned likelihood method to scan the data set in search for DM-like signals in ANTARES data. Results obtained upon unblinding 3170 days of data reconstructed with updated methods are presented, which provides a larger, and more accurate, data set than a previously published result using 2101 days. A non-observation of dark matter is converted into limits on the velocity-averaged cross section for WIMP pair annihilation., Centre National de la Recherche Scientifique (CNRS), French Atomic Energy Commission, Commission Europeenne (FEDER fund), European Union (EU), Institut Universitaire de France (IUF), IdEx program at Sorbonne Paris Cite ANR-10-LABX-0023 ANR-11-IDEX-0005-02, UnivEarthS Labex program at Sorbonne Paris Cite ANR-10-LABX-0023 ANR-11-IDEX-0005-02, Labex OCEVU ANR-11-LABX-0060, French National Research Agency (ANR) ANR-11-IDEX-0001-02, Region Ile-de-France, Region Grand-Est, Region Provence-Alpes-Cote d'Azur, Federal Ministry of Education & Research (BMBF), Instituto Nazionale di Fisica Nucleare(INFN), Italy, Netherlands Organization for Scientific Research (NWO) Netherlands Government, Council of the President of the Russian Federation for young scientists and leading scientific schools supporting grants, Russia, Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI), Romania, Ministerio de Ciencia, Innovacion y Universidades(MCIU): Programa Estatal de Generacion de Conocimiento PGC2018-096663-B-C41 PGC2018-096663-A-C42 PGC2018-096663-B-C43 PGC2018-096663-B-C44, Severo Ochoa Centre of Excellence and MultiDark Consolider (MCIU), Junta de Andalucia SOMM17/6104/UGR, Generalitat Valenciana: Grisolia, Spain GRISOLIA/2018/119, Ministry of Higher Education, Scientific Research and Training, Morocco
Published: 2020

17. ANTARES Neutrino Search for Time and Space Correlations with IceCube High-energy Neutrino Events

Author: Antares Collaboration, Albert A., Andre M., Anghinolfi M., Anton G., Ardid M., Aubert J. -J., Aublin J., Baret B., Barrios-Marti J., Basa S., Belhorma B., Bertin V., Biagi S., Bormuth R., Boumaaza J., Bourret S., Bouta M., Bouwhuis M. C., Branzas H., Bruijn R., Brunner J., Busto J., Capone A., Caramete L., Carr J., Celli S., Chabab M., El Moursli R. C., Chiarusi T., Circella M., Coleiro A., Colomer M., Coniglione R., Costantini H., Coyle P., Creusot A., Diaz A. F., Deschamps A., Distefano C., Palma I. D., Domi A., Dona R., Donzaud C., Dornic D., Drouhin D., Eberl T., Bojaddaini I. E., Khayati N. E., Elsasser D., Enzenhofer A., Ettahiri A., Fassi F., Fermani P., Ferrara G., Fusco L., Gay P., Glotin H., Gozzini R., Gregoire T., Ruiz R. G., Graf K., Hallmann S., Haren H. V., Heijboer A. J., Hello Y., Hernandez-Rey J. J., Hossl J., Hofestadt J., Illuminati G., James C. W., Jong M. D., Jongen M., Kadler M., Kalekin O., Katz U., Khan-Chowdhury N. R., Kouchner A., Kreter M., Kreykenbohm I., Kulikovskiy V., Lahmann R., Breton R. L., Lefevre D., Leonora E., Levi G., Lincetto M., Lopez-Coto D., Lotze M., Loucatos S., Maggi G., Marcelin M., Margiotta A., Marinelli A., Martinez-Mora J. A., Mele R., Melis K., Migliozzi P., Moussa A., Navas S., Nezri E., Nielsen C., Nunez A., Organokov M., Pavalas G. E., Pellegrino C., Perrin-Terrin M., Piattelli P., Popa V., Pradier T., Quinn L., Racca C., Randazzo N., Riccobene G., Sanchez-Losa A., Salah-Eddine A., Salvadori I., Samtleben D. F. E., Sanguineti M., Sapienza P., Schussler F., Spurio M., Stolarczyk T., Taiuti M., Tayalati Y., Thakore T., Trovato A., Vallage B., Elewyck V. V., Versari F., Viola S., Vivolo D., Wilms J., Zaborov D., Zornoza J. D., Z niga J., Institut Pluridisciplinaire Hubert Curien (IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Laboratoire d'Informatique et Systèmes (LIS), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Institut méditerranéen d'océanologie (MIO), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Groupe de Recherche en Physique des Hautes Energies (GRPHE), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut Universitaire de Technologie de Colmar, ANTARES, KM3NeT (IHEF, IoP, FNWI), ANTARES (IHEF, IoP, FNWI), IHEF (IoP, FNWI), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-IUT de Colmar, Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J.-J., Aublin, J., Baret, B., Barrios-Martí, J., Basa, S., Belhorma, B., Bertin, V., Biagi, S., Bormuth, R., Boumaaza, J., Bourret, S., Bouta, M., Bouwhuis, M. C., Brânzaş, H., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Celli, S., Chabab, M., El Moursli, R. Cherkaoui, Chiarusi, T., Circella, M., Coleiro, A., Colomer, M., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., Díaz, A. F., Deschamps, A., Distefano, C., Palma, I. Di, Domi, A., Donà, R., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., Bojaddaini, I. El, Khayati, N. El, Elsässer, D., Enzenhöfer, A., Ettahiri, A., Fassi, F., Fermani, P., Ferrara, G., Fusco, L., Gay, P., Glotin, H., Gozzini, R., Grégoire, T., Ruiz, R. Gracia, Graf, K., Hallmann, S., Haren, H. van, Heijboer, A. J., Hello, Y., Hernández-Rey, J. J., Hößl, J., Hofestädt, J., Illuminati, G., James, C. W., Jong, M. de, Jongen, M., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N. R., Kouchner, A., Kreter, M., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Breton, R. Le, Lefèvre, D., Leonora, E., Levi, G., Lincetto, M., Lopez-Coto, D., Lotze, M., Loucatos, S., Maggi, G., Marcelin, M., Margiotta, A., Marinelli, A., Martínez-Mora, J. A., Mele, R., Melis, K., Migliozzi, P., Moussa, A., Navas, S., Nezri, E., Nielsen, C., Nuñez, A., Organokov, M., Păvălaş, G. E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Popa, V., Pradier, T., Quinn, L., Racca, C., Randazzo, N., Riccobene, G., Sánchez-Losa, A., Salah-Eddine, A., Salvadori, I., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schüssler, F., Spurio, M., Stolarczyk, Th., Taiuti, M., Tayalati, Y., Thakore, T., Trovato, A., Vallage, B., Elewyck, V. Van, Versari, F., Viola, S., Vivolo, D., Wilms, J., Zaborov, D., Zornoza, J. D., Zúñiga, J., Antares, Collaboration, Andre, M., Aubert, J. -J., Barrios-Marti, J., Branzas, H., El Moursli, R. C., Diaz, A. F., Palma, I. D., Dona, R., Bojaddaini, I. E., Khayati, N. E., Elsasser, D., Enzenhofer, A., Gregoire, T., Ruiz, R. G., Haren, H. V., Hernandez-Rey, J. J., Hossl, J., Hofestadt, J., Jong, M. D., Breton, R. L., Lefevre, D., Martinez-Mora, J. A., Nunez, A., Pavalas, G. E., Sanchez-Losa, A., Schussler, F., Stolarczyk, T., Elewyck, V. V., Z niga, J., Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Toulon (UTLN), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Centre National de la Recherche Scientifique (CNRS)-Université de Toulon (UTLN)-Aix Marseille Université (AMU)-Institut de Recherche pour le Développement (IRD), Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Albert, A, Andre, M, Anghinolfi, M, Anton, G, Ardid, M, Aubert, Jj, Aublin, J, Baret, B, Barrios-Marti, J, Basa, S, Belhorma, B, Bertin, V, Biagi, S, Bormuth, R, Boumaaza, J, Bourret, S, Bouta, M, Bouwhuis, Mc, Branzas, H, Bruijn, R, Brunner, J, Busto, J, Capone, A, Caramete, L, Carr, J, Celli, S, Chabab, M, El Moursli, Rc, Chiarusi, T, Circella, M, Coleiro, A, Colomer, M, Coniglione, R, Costantini, H, Coyle, P, Creusot, A, Diaz, Af, Deschamps, A, Distefano, C, Di Palma, I, Domi, A, Dona, R, Donzaud, C, Dornic, D, Drouhin, D, Eberl, T, El Bojaddaini, I, El Khayati, N, Elsasser, D, Enzenhofer, A, Ettahiri, A, Fassi, F, Fermani, P, Ferrara, G, Fusco, L, Gay, P, Glotin, H, Gozzini, R, Gregoire, T, Ruiz, Rg, Graf, K, Hallmann, S, van Haren, H, Heijboer, Aj, Hello, Y, Hernandez-Rey, Jj, Hossl, J, Hofestadt, J, Illuminati, G, James, Cw, de Jong, M, Jongen, M, Kadler, M, Kalekin, O, Katz, U, Khan-Chowdhury, Nr, Kouchner, A, Kreter, M, Kreykenbohm, I, Kulikovskiy, V, Lahmann, R, Le Breton, R, Lefevre, D, Leonora, E, Levi, G, Lincetto, M, Lopez-Coto, D, Lotze, M, Loucatos, S, Maggi, G, Marcelin, M, Margiotta, A, Marinelli, A, Martinez-Mora, Ja, Mele, R, Melis, K, Migliozzi, P, Moussa, A, Navas, S, Nezri, E, Nielsen, C, Nunez, A, Organokov, M, Pavalas, Ge, Pellegrino, C, Perrin-Terrin, M, Piattelli, P, Popa, V, Pradier, T, Quinn, L, Racca, C, Randazzo, N, Riccobene, G, Sanchez-Losa, A, Salah-Eddine, A, Salvadori, I, Samtleben, Dfe, Sanguineti, M, Sapienza, P, Schussler, F, Spurio, M, Stolarczyk, T, Taiuti, M, Tayalati, Y, Thakore, T, Trovato, A, Vallage, B, Van Elewyck, V, Versari, F, Viola, S, Vivolo, D, Wilms, J, Zaborov, D, Zornoza, Jd, Zuniga, J, Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut Universitaire de Technologie de Colmar-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Centre Tecnològic de Vilanova i la Geltrú, Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, and Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)
Subjects: Astrofísica, [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], High energy, 010504 meteorology & atmospheric sciences, astroparticle physics, neutrinos, neutrino: energy: high, Maximum likelihood, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, power spectrum, 01 natural sciences, Arrival time, law.invention, IceCube, Telescope, law, 0103 physical sciences, Neutrins, Neutrinos, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, Spectral index, ANTARES, Spacetime, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, astroparticle physic, Astronomy and Astrophysics, neutrino: particle source, Neutrino astrophysics, 13. Climate action, Space and Planetary Science, Física::Astronomia i astrofísica [Àrees temàtiques de la UPC], FISICA APLICADA, correlation, neutrino: flavor, Neutrino, Astroparticle physics, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Event (particle physics)
Abstract: [EN] In past years the IceCube Collaboration has reported the observation of astrophysical high-energy neutrino events in several analyses. Despite compelling evidence for the first identification of a neutrino source, TXS 0506+056, the origin of the majority of these events is still unknown. In this paper, we search for a possible transient origin of the IceCube astrophysical events using neutrino events detected by the ANTARES telescope. The arrival time and direction of 6894 track-like and 160 shower-like events detected over 2346 days of livetime are examined to search for coincidences with 54 IceCube high-energy track-like neutrino events, by means of a maximum likelihood method. No significant correlation is observed and upper limits on the one-flavor neutrino fluence from the direction of the IceCube candidates are derived. The nonobservation of time and space correlation within the time window of 0.1 days with the two most energetic IceCube events constrains the spectral index of a possible point-like transient neutrino source to be harder than -2.3 and -2.4 for each event, respectively., The authors acknowledge the financial support of the funding agencies: Centre National de la Recherche Scientifique (CNRS), Commissariat a l'energie atomique et aux energies alternatives (CEA), Commission Europeenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), IdEx program and UnivEarthS Labex program at Sorbonne Paris Cite (ANR-10-LABX-0023 and ANR-11-IDEX-0005-02), Labex OCEVU (ANR-11-LABX-0060) and the A*MIDEX project (ANR-11-IDEX-0001-02), Region Ile de-France (DIM-ACAV), Region Alsace (contrat CPER), Region Provence-Alpes-Cote d'Azur, Departement du Var and Ville de La Seyne-sur-Mer, France; Bundesministerium fur Bildung und Forschung (BMBF), Germany; Istituto Nazionale di Fisica Nucleare (INFN), Italy; Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO), the Netherlands; Council of the President of the Russian Federation for young scientists and leading scientific schools supporting grants, Russia; Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI), Romania; Ministerio de Economia y Competitividad (MINECO): Plan Estatal de Investigacion (refs. FPA2015-65150-C3-1-P, -2-P and -3-P, (MINECO/FEDER)), Severo Ochoa Centre of Excellence and Red Consolider MultiDark (MINECO), and Prometeo and Grisolia programs (Generalitat Valenciana), Spain; Ministry of Higher Education, Scientific Research and Professional Training, Morocco. We also acknowledge the technical support of Ifremer, AIM and Foselev Marine for the sea operation and the CC-IN2P3 for the computing facilities.
Published: 2019

18. Measuring the atmospheric neutrino oscillation parameters and constraining the 3+1 neutrino model with ten years of ANTARES data

Author: Jose Busto, T. Thakore, J. Zúñiga, A. Enzenhöfer, A. Salah-Eddine, M. Taiuti, Daniele Vivolo, S. Navas, V. Bertin, Th. Stolarczyk, G.E. Păvălaş, Thierry Pradier, T. Grégoire, M. Kreter, Massimiliano Lincetto, D. Drouhin, B. Belhorma, R. Mele, Gisela Anton, Giuseppe Levi, J. Hößl, I. Kreykenbohm, Vladimir Kulikovskiy, R. Gracia Ruiz, Giulia Illuminati, Alba Domi, F. Versari, C. Lachaud, Paolo Fermani, I. El Bojaddaini, C. Nielsen, Carmelo Pellegrino, R. Cherkaoui El Moursli, V. Popa, J. Brunner, M. Organokov, P. Migliozzi, M. Perrin-Terrin, T. Avgitas, P. Piattelli, Steffen Hallmann, Giovanna Ferrara, J-J. Aubert, M. Circella, J.D. Zornoza, D. Zaborov, S. Loucatos, C. Racca, S.F. Biagi, Corinne Donzaud, I. Salvadori, Paolo Sapienza, O. Kalekin, M. Jongen, Anne Deschamps, Bruny Baret, Matthias Kadler, C. Distefano, H. van Haren, R. Gozzini, Heide Costantini, D. F. E. Samtleben, R. Le Breton, Matteo Sanguineti, Kay Graf, Karel Melis, H. Brânzaş, Yann Hello, A. Creusot, G. Riccobene, N. Randazzo, S. Bourret, Damien Dornic, A. Nuñez, Alessia Capone, J. Barrios-Martí, G. Maggi, J.A. Martínez-Mora, M. Colomer, Jörn Wilms, Farida Fassi, N.R. Khan-Chowdhury, Robert Lahmann, C. W. James, R. Donà, A. Marinelli, Maurizio Spurio, J. Carr, A.J. Heijboer, A. Ettahiri, Tommaso Chiarusi, Luigi Antonio Fusco, Dominique Lefèvre, M.C. Bouwhuis, M. de Jong, Annarita Margiotta, Michel André, R. Bormuth, M. Marcelin, Emanuele Leonora, Dominik Elsässer, Hervé Glotin, V. Van Elewyck, Mohamed Chabab, U. Katz, F. Schüssler, M. Ardid, M. Anghinolfi, N. El Khayati, S. Basa, L. Quinn, J.J. Hernández-Rey, Yahya Tayalati, A. Trovato, L. Caramete, Arnauld Albert, R. Coniglione, J. Hofestädt, Jihad Boumaaza, Silvia Celli, Thomas Eberl, M. Lotze, Antoine Kouchner, A. Sánchez-Losa, P. Coyle, Alexis Coleiro, E. Nezri, J. Aublin, Salvatore Viola, R. Bruijn, Abdelilah Moussa, I. Di Palma, Antonio F. Díaz, B. Vallage, KM3NeT (IHEF, IoP, FNWI), ANTARES (IHEF, IoP, FNWI), IHEF (IoP, FNWI), Centre Tecnològic de Vilanova i la Geltrú, Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de Physique de Clermont (LPC), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Université Paris-Sud - Paris 11 (UP11), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Informatique et Systèmes (LIS), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Institut méditerranéen d'océanologie (MIO), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Groupe de Recherche en Physique des Hautes Energies (GRPHE), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-IUT de Colmar, Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), ANTARES, Albert, A., Andre, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J. -J., Aublin, J., Avgitas, T., Baret, B., Barrios-Marti, J., Basa, S., Belhorma, B., Bertin, V., Biagi, S., Bormuth, R., Boumaaza, J., Bourret, S., Bouwhuis, M. C., Branzas, H., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Celli, S., Chabab, M., Cherkaoui El Moursli, R., Chiarusi, T., Circella, M., Coleiro, A., Colomer, M., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., Diaz, A. F., Deschamps, A., Distefano, C., Di Palma, I., Domi, A., Dona, R., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., El Bojaddaini, I., El Khayati, N., Elsasser, D., Enzenhofer, A., Ettahiri, A., Fassi, F., Fermani, P., Ferrara, G., Fusco, L., Gay, P., Glotin, H., Gozzini, R., Gregoire, T., Gracia Ruiz, R., Graf, K., Hallmann, S., van Haren, H., Heijboer, A. J., Hello, Y., Hernandez-Rey, J. J., Hossl, J., Hofestadt, J., Illuminati, G., James, C. W., de Jong, M., Jongen, M., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N. R., Kouchner, A., Kreter, M., Kreykenbohm, I., Kulikovskiy, V., Lachaud, C., Lahmann, R., Le Breton, R., Lefevre, D., Leonora, E., Levi, G., Lincetto, M., Lotze, M., Loucatos, S., Maggi, G., Marcelin, M., Margiotta, A., Marinelli, A., Martinez-Mora, J. A., Mele, R., Melis, K., Migliozzi, P., Moussa, A., Navas, S., Nezri, E., Nielsen, C., Nunez, A., Organokov, M., Pavalas, G. E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Popa, V., Pradier, T., Quinn, L., Racca, C., Randazzo, N., Riccobene, G., Sanchez-Losa, A., Salah-Eddine, A., Salvadori, I., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schussler, F., Spurio, M., Stolarczyk, T., Taiuti, M., Tayalati, Y., Thakore, T., Trovato, A., Vallage, B., Van Elewyck, V., Versari, F., Viola, S., Vivolo, D., Wilms, J., Zaborov, D., Zornoza, J. D., Zuniga, J., Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut Universitaire de Technologie de Colmar, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Ministerio de Economía y Competitividad (España), Albert, A, Andre, M, Anghinolfi, M, Anton, G, Ardid, M, Aubert, Jj, Aublin, J, Avgitas, T, Baret, B, Barrios-Marti, J, Basa, S, Belhorma, B, Bertin, V, Biagi, S, Bormuth, R, Boumaaza, J, Bourret, S, Bouwhuis, Mc, Branzas, H, Bruijn, R, Brunner, J, Busto, J, Capone, A, Caramete, L, Carr, J, Celli, S, Chabab, M, El Moursli, Rc, Chiarusi, T, Circella, M, Coleiro, A, Colomer, M, Coniglione, R, Costantini, H, Coyle, P, Creusot, A, Diaz, Af, Deschamps, A, Distefano, C, Di Palma, I, Domi, A, Dona, R, Donzaud, C, Dornic, D, Drouhin, D, Eberl, T, El Bojaddaini, I, El Khayati, N, Elsasser, D, Enzenhofer, A, Ettahiri, A, Fassi, F, Fermani, P, Ferrara, G, Fusco, L, Gay, P, Glotin, H, Gozzini, R, Gregoire, T, Ruiz, Rg, Graf, K, Hallmann, S, van Haren, H, Heijboer, Aj, Hello, Y, Hernandez-Rey, Jj, Hossl, J, Hofestadt, J, Illuminati, G, James, Cw, de Jong, M, Jongen, M, Kadler, M, Kalekin, O, Katz, U, Khan-Chowdhury, Nr, Kouchner, A, Kreter, M, Kreykenbohm, I, Kulikovskiy, V, Lachaud, C, Lahmann, R, Le Breton, R, Lefevre, D, Leonora, E, Levi, G, Lincetto, M, Lotze, M, Loucatos, S, Maggi, G, Marcelin, M, Margiotta, A, Marinelli, A, Martinez-Mora, Ja, Mele, R, Melis, K, Migliozzi, P, Moussa, A, Navas, S, Nezri, E, Nielsen, C, Nunez, A, Organokov, M, Pavalas, Ge, Pellegrino, C, Perrin-Terrin, M, Piattelli, P, Popa, V, Pradier, T, Quinn, L, Racca, C, Randazzo, N, Riccobene, G, Sanchez-Losa, A, Salah-Eddine, A, Salvadori, I, Samtleben, Dfe, Sanguineti, M, Sapienza, P, Schussler, F, Spurio, M, Stolarczyk, T, Taiuti, M, Tayalati, Y, Thakore, T, Trovato, A, Vallage, B, Van Elewyck, V, Versari, F, Viola, S, Vivolo, D, Wilms, J, Zaborov, D, Zornoza, Jd, Zuniga, J, Albert A., Andre M., Anghinolfi M., Anton G., Ardid M., Aubert J.-J., Aublin J., Avgitas T., Baret B., Barrios-Marti J., Basa S., Belhorma B., Bertin V., Biagi S., Bormuth R., Boumaaza J., Bourret S., Bouwhuis M.C., Branzas H., Bruijn R., Brunner J., Busto J., Capone A., Caramete L., Carr J., Celli S., Chabab M., Cherkaoui El Moursli R., Chiarusi T., Circella M., Coleiro A., Colomer M., Coniglione R., Costantini H., Coyle P., Creusot A., Diaz A.F., Deschamps A., Distefano C., Di Palma I., Domi A., Dona R., Donzaud C., Dornic D., Drouhin D., Eberl T., El Bojaddaini I., El Khayati N., Elsasser D., Enzenhofer A., Ettahiri A., Fassi F., Fermani P., Ferrara G., Fusco L., Gay P., Glotin H., Gozzini R., Gregoire T., Gracia Ruiz R., Graf K., Hallmann S., van Haren H., Heijboer A.J., Hello Y., Hernandez-Rey J.J., Hossl J., Hofestadt J., Illuminati G., James C.W., de Jong M., Jongen M., Kadler M., Kalekin O., Katz U., Khan-Chowdhury N.R., Kouchner A., Kreter M., Kreykenbohm I., Kulikovskiy V., Lachaud C., Lahmann R., Le Breton R., Lefevre D., Leonora E., Levi G., Lincetto M., Lotze M., Loucatos S., Maggi G., Marcelin M., Margiotta A., Marinelli A., Martinez-Mora J.A., Mele R., Melis K., Migliozzi P., Moussa A., Navas S., Nezri E., Nielsen C., Nunez A., Organokov M., Pavalas G.E., Pellegrino C., Perrin-Terrin M., Piattelli P., Popa V., Pradier T., Quinn L., Racca C., Randazzo N., Riccobene G., Sanchez-Losa A., Salah-Eddine A., Salvadori I., Samtleben D.F.E., Sanguineti M., Sapienza P., Schussler F., Spurio M., Stolarczyk T., Taiuti M., Tayalati Y., Thakore T., Trovato A., Vallage B., Van Elewyck V., Versari F., Viola S., Vivolo D., Wilms J., Zaborov D., Zornoza J.D., Zuniga J., Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Centre National de la Recherche Scientifique (CNRS)-Université de Toulon (UTLN)-Aix Marseille Université (AMU)-Institut de Recherche pour le Développement (IRD), Institut Universitaire de Technologie de Colmar-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Toulon (UTLN), and COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])
Subjects: Astrofísica, Sterile neutrino, Physics::Instrumentation and Detectors, 01 natural sciences, 7. Clean energy, High Energy Physics - Experiment, neutrino/mu: atmosphere, High Energy Physics - Experiment (hep-ex), energy: threshold, High Energy Physics - Phenomenology (hep-ph), neutrino: atmosphere, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Muon neutrino, S067P23, Physics, Neutrino detectors and telescopes (experiments), Oscillation, 4. Education, Astrophysics::Instrumentation and Methods for Astrophysics, neutrino: sterile, Neutrino Detectors and Telescopes (experiments), High Energy Physics - Phenomenology, neutrino: detector, Neutrino detector, Neutrino, Atmospheric neutrino, Nuclear and High Energy Physics, Particle physics, Astrophysics::High Energy Astrophysical Phenomena, Neutrino telescope, neutrino: mass difference, FOS: Physical sciences, statistical analysis, S067DM1, 0103 physical sciences, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, Neutrins, Neutrinos, 010306 general physics, Neutrino oscillation, neutrino: model, ANTARES, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, neutrino: mixing angle, Neutrino astrophysics, 13. Climate action, [PHYS.HPHE]Physics [physics]/High Energy Physics - Phenomenology [hep-ph], Física::Astronomia i astrofísica [Àrees temàtiques de la UPC], FISICA APLICADA, lcsh:QC770-798, High Energy Physics::Experiment, neutrino: oscillation, experimental results
Abstract: The ANTARES neutrino telescope has an energy threshold of a few tens of GeV. This allows to study the phenomenon of atmospheric muon neutrino disappearance due to neutrino oscillations. In a similar way, constraints on the 3+1 neutrino model, which foresees the existence of one sterile neutrino, can be inferred. Using data collected by the ANTARES neutrino telescope from 2007 to 2016, a new measurement of m2 32 and 23 has been performed | which is consistent with world best- t values | and constraints on the 3+1 neutrino model have been derived., Centre National de la Recherche Scienti que (CNRS), Commissariat a l' energie atomique et aux energies alternatives (CEA), Commission Européenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), IdEx program and UnivEarthS Labex program at Sorbonne Paris Cité (ANR-10-LABX-0023 and ANR-11-IDEX-0005-02), Labex OCEVU (ANR-11-LABX-0060) and the A*MIDEX project (ANR-11-IDEX-0001-02), Région ÎIle-de- France (DIM-ACAV), Région Alsace (contrat CPER), Région Provence-Alpes-Côte d'Azur, Département du Var and Ville de La Seyne-sur-Mer, Bundesministerium für Bildung und Forschung (BMBF), Istituto Nazionale di Fisica Nucleare (INFN), Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO), Council of the President of the Russian Federation for young scientists and leading scientific schools supporting grants, Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDIÇ), Ministerio de Economía y Competitividad (MINECO): Plan Estatal de Investigación (refs. FPA2015-65150-C3-1-P, -2-P and -3-P, (MINECO/FEDER)), Severo Ochoa Centre of Excellence and Red Consolider MultiDark (MINECO), and Prometeo and Grisolía programs (Generalitat Valenciana), Ministry of Higher Education, Scienti c Research and Professional Training
Published: 2019

19. A Search for Cosmic Neutrino and Gamma-Ray Emitting Transients in 7.3 yr of ANTARES and Fermi LAT Data

Author: Ayala Solares, H.A., Cowen, D.F., DeLaunay, J.J., Fox, D.B., Keivani, A., Mostafá, M., Murase, K., Turley, Colin F., Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J.-J., Aublin, J., Baret, B., Barrios-Martí, J., Basa, S., Belhorma, B., Bertin, V., Biagi, S., Bormuth, R., Boumaaza, J., Bourret, S., Bouta, M., Bouwhuis, M.C., Brânzaş, H., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Celli, S., Chabab, M., Cherkaoui El Moursli, R., Chiarusi, T., Circella, M., Coleiro, A., Colomer, M., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., Dí{}az, A.F., Deschamps, A., Distefano, C., Di Palma, I., Domi, A., Donà, R., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., El Bojaddaini, I., El Khayati, N., Elsässer, D., Enzenhöfer, A., Ettahiri, A., Fassi, F., Fermani, P., Ferrara, G., Fusco, L., Gay, P., Glotin, H., Gozzini, R., Grégoire, T., Gracia Ruiz, R., Graf, K., Hallmann, S., Van Haren, H., Heijboer, A.J., Hello, Y., Hernández-Rey, J.J., Hößl, J., Hofestädt, J., Illuminati, G., James, C.W., De Jong, M., Jongen, M., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N.R., Kouchner, A., Kreter, M., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Le Breton, R., Lefèvre, D., Leonora, E., Levi, G., Lincetto, M., Lopez-Coto, D., Lotze, M., Loucatos, S., Maggi, G., Marcelin, M., Margiotta, A., Marinelli, A., Martínez-Mora, J.A., Mele, R., Melis, K., Migliozzi, P., Moussa, A., Navas, S., Nezri, E., Nielsen, C., Nuñez, A., Organokov, M., Păvălaş, G.E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Popa, V., Pradier, T., Quinn, L., Racca, C., Randazzo, N., Riccobene, G., Sánchez-Losa, A., Salah-Eddine, A., Salvadori, I., Samtleben, D.F.E., Sanguineti, M., Sapienza, P., Schüssler, F., Spurio, M., Stolarczyk, Th., Taiuti, M., Tayalati, Y., Thakore, T., Trovato, A., Vallage, B., Van Elewyck, V., Versari, F., Viola, S., Vivolo, D., Wilms, J., Zaborov, D., Zornoza, J.D., Zúñiga, J., Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire d'Astrophysique de Marseille (LAM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Informatique et Systèmes (LIS), Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Institut méditerranéen d'océanologie (MIO), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Toulon (UTLN), Université de Toulon - UFR Sciences et Techniques (UTLN UFR ScT), Université de Toulon (UTLN), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Groupe de Recherche en Physique des Hautes Energies (GRPHE), Institut Universitaire de Technologie de Colmar-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), AMON, ANTARES, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Toulon (UTLN)-Aix Marseille Université (AMU)-Institut de Recherche pour le Développement (IRD), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-IUT de Colmar, Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut Universitaire de Technologie de Colmar, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA), Solares, Haa, Cowen, Df, Delaunay, Jj, Fox, Db, Keivani, A, Mostafa, M, Murase, K, Turley, Cf, Albert, A, Andre, M, Anghinolfi, M, Anton, G, Ardid, M, Aubert, Jj, Aublin, J, Baret, B, Barrios-Marti, J, Basa, S, Belhorma, B, Bertin, V, Biagi, S, Bormuth, R, Boumaaza, J, Bourret, S, Bouta, M, Bouwhuis, Mc, Branzas, H, Bruijn, R, Brunner, J, Busto, J, Capone, A, Caramete, L, Carr, J, Celli, S, Chabab, M, El Moursli, Rc, Chiarusi, T, Circella, M, Coleiro, A, Colomer, M, Coniglione, R, Costantini, H, Coyle, P, Creusot, A, Diaz, Af, Deschamps, A, Distefano, C, Di Palma, I, Domi, A, Dona, R, Donzaud, C, Dornic, D, Drouhin, D, Eberl, T, El Bojaddaini, I, El Khayati, N, Elsasser, D, Enzenhofer, A, Ettahiri, A, Fassi, F, Fermani, P, Ferrara, G, Fusco, L, Gay, P, Glotin, H, Gozzini, R, Gregoire, T, Ruiz, Rg, Graf, K, Hallmann, S, van Haren, H, Heijboer, Aj, Hello, Y, Hernandez-Rey, Jj, Hossl, J, Hofestadt, J, Illuminati, G, James, Cw, de Jong, M, Jongen, M, Kadler, M, Kalekin, O, Katz, U, Khan-Chowdhury, Nr, Kouchner, A, Kreter, M, Kreykenbohm, I, Kulikovskiy, V, Lahmann, R, Le Breton, R, Lefevre, D, Leonora, E, Levi, G, Lincetto, M, Lopez-Coto, D, Lotze, M, Loucatos, S, Maggi, G, Marcelin, M, Margiotta, A, Marinelli, A, Martinez-Mora, Ja, Mele, R, Melis, K, Migliozzi, P, Moussa, A, Navas, S, Nezri, E, Nielsen, C, Nunez, A, Organokov, M, Pavalas, Ge, Pellegrino, C, Perrin-Terrin, M, Piattelli, P, Popa, V, Pradier, T, Quinn, L, Racca, C, Randazzo, N, Riccobene, G, Sanchez-Losa, A, Salah-Eddine, A, Salvadori, I, Samtleben, Dfe, Sanguineti, M, Sapienza, P, Schussler, F, Spurio, M, Stolarczyk, T, Taiuti, M, Tayalati, Y, Thakore, T, Trovato, A, Vallage, B, Van Elewyck, V, Versari, F, Viola, S, Vivolo, D, Wilms, J, Zaborov, D, Zornoza, Jd, Zuniga, J, Ayala Solares H.A., Cowen D.F., Delaunay J.J., Fox D.B., Keivani A., Mostafa M., Murase K., Turley C.F., Albert A., Andre M., Anghinolfi M., Anton G., Ardid M., Aubert J.-J., Aublin J., Baret B., Barrios-Marti J., Basa S., Belhorma B., Bertin V., Biagi S., Bormuth R., Boumaaza J., Bourret S., Bouta M., Bouwhuis M.C., Br nzas H., Bruijn R., Brunner J., Busto J., Capone A., Caramete L., Carr J., Celli S., Chabab M., El Moursli R.C., Chiarusi T., Circella M., Coleiro A., Colomer M., Coniglione R., Costantini H., Coyle P., Creusot A., Diaz A.F., Deschamps A., Distefano C., Palma I.D., Domi A., Don R., Donzaud C., Dornic D., Drouhin D., Eberl T., Bojaddaini I.E., Khayati N.E., Els sser D., Enzenhofer A., Ettahiri A., Fassi F., Fermani P., Ferrara G., Fusco L., Gay P., Glotin H., Gozzini R., Gregoire T., Ruiz R.G., Graf K., Hallmann S., Haren H.V., Heijboer A.J., Hello Y., Hernandez-Rey J.J., Hossl J., Hofest dt J., Illuminati G., James C.W., Jong M.D., Jongen M., Kadler M., Kalekin O., Katz U., Khan-Chowdhury N.R., Kouchner A., Kreter M., Kreykenbohm I., Kulikovskiy V., Lahmann R., Breton R.L., Lef vre D., Leonora E., Levi G., Lincetto M., Lopez-Coto D., Lotze M., Loucatos S., Maggi G., Marcelin M., Margiotta A., Marinelli A., Martinez-Mora J.A., Mele R., Melis K., Migliozzi P., Moussa A., Navas S., Nezri E., Nielsen C., Nuñez A., Organokov M., Pavalas G.E., Pellegrino C., Perrin-Terrin M., Piattelli P., Popa V., Pradier T., Quinn L., Racca C., Randazzo N., Riccobene G., Sanchez-Losa A., Salah-Eddine A., Salvadori I., Samtleben D.F.E., Sanguineti M., Sapienza P., Schussler F., Spurio M., Stolarczyk T., Taiuti M., Tayalati Y., Thakore T., Trovato A., Vallage B., Elewyck V.V., Versari F., Viola S., Vivolo D., Wilms J., Zaborov D., Zornoza J.D., Zuñiga J., Ayala Solares, H. A., Cowen, D. F., Delaunay, J. J., Fox, D. B., Keivani, A., Mostafa, M., Murase, K., Turley, C. F., Albert, A., Andre, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J. -J., Aublin, J., Baret, B., Barrios-Marti, J., Basa, S., Belhorma, B., Bertin, V., Biagi, S., Bormuth, R., Boumaaza, J., Bourret, S., Bouta, M., Bouwhuis, M. C., Br nzas, H., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Celli, S., Chabab, M., El Moursli, R. C., Chiarusi, T., Circella, M., Coleiro, A., Colomer, M., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., Diaz, A. F., Deschamps, A., Distefano, C., Palma, I. D., Domi, A., Don, R., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., Bojaddaini, I. E., Khayati, N. E., Els sser, D., Enzenhofer, A., Ettahiri, A., Fassi, F., Fermani, P., Ferrara, G., Fusco, L., Gay, P., Glotin, H., Gozzini, R., Gregoire, T., Ruiz, R. G., Graf, K., Hallmann, S., Haren, H. V., Heijboer, A. J., Hello, Y., Hernandez-Rey, J. J., Hossl, J., Hofest dt, J., Illuminati, G., James, C. W., Jong, M. D., Jongen, M., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N. R., Kouchner, A., Kreter, M., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Breton, R. L., Lef vre, D., Leonora, E., Levi, G., Lincetto, M., Lopez-Coto, D., Lotze, M., Loucatos, S., Maggi, G., Marcelin, M., Margiotta, A., Marinelli, A., Martinez-Mora, J. A., Mele, R., Melis, K., Migliozzi, P., Moussa, A., Navas, S., Nezri, E., Nielsen, C., Nuñez, A., Organokov, M., Pavalas, G. E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Popa, V., Pradier, T., Quinn, L., Racca, C., Randazzo, N., Riccobene, G., Sanchez-Losa, A., Salah-Eddine, A., Salvadori, I., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schussler, F., Spurio, M., Stolarczyk, T., Taiuti, M., Tayalati, Y., Thakore, T., Trovato, A., Vallage, B., Elewyck, V. V., Versari, F., Viola, S., Vivolo, D., Wilms, J., Zaborov, D., Zornoza, J. D., Zuñiga, J., PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), and Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])
Subjects: 010504 meteorology & atmospheric sciences, neutrino: energy: high, gamma-ray burst: general, Astrophysics, 01 natural sciences, 7. Clean energy, Coincidence, 010303 astronomy & astrophysics, Monte Carlo, cosmic ray, BL Lacertae objects: general, cosmic rays, gamma rays: general, neutrinos, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), COSMIC cancer database, Gamma ray, general [Gamma-ray burst], cascade, ANTARES, FERMI-LAT, neutrino telescopes, Neutrino, Astrophysics - High Energy Astrophysical Phenomena, burst, [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Astrophysics::High Energy Astrophysical Phenomena, general [Gamma rays], brightness, FOS: Physical sciences, Cosmic ray, gamma ray: burst, GLAST, 0103 physical sciences, Neutrinos, Blazar, Cosmic rays, neutrino: multiplicity, 0105 earth and related environmental sciences, ANTARES, general [BL Lacertae objects], Astronomy and Astrophysics, sensitivity, tracks, messenger, injection, 13. Climate action, Space and Planetary Science, FISICA APLICADA, correlation, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], statistical, Energy (signal processing), Fermi Gamma-ray Space Telescope
Abstract: [EN] We analyze 7.3 yr of ANTARES high-energy neutrino and Fermi Large Area Telescope (LAT) g-ray data in search of cosmic neutrino + g-ray (n+g) transient sources or source populations. Our analysis has the potential to detect either individual n+g transient sources (durations dt5% of the observed gamma-coincident neutrinos in the track data at 90% concidence. Applying our analysis to the unscrambled data reveals no individual n+g events of high significance; two ANTARES track+ Fermi g-ray events are identi¿ed that exceed a once per decade false alarm rate threshold (p = 17%).No evidence for subthreshold ¿+¿ source populations is found among the track (p = 39%) or cascade (p = 60%) events. Exploring a possible correlation of high-energy neutrino directions with Fermi g-ray sky brightness identi¿ed in previous work yields no added support for this correlation. While TXS 0506+056, a blazar and variable (nontransient) Fermi g-ray source, has recently been identified as the first source of high-energy neutrinos, the challenges in reconciling observations of the Fermi g-ray sky, the IceCube high-energy cosmic neutrinos, and ultrahigh-energy cosmic rays using only blazars suggest a significant contribution by other source populations. Searches for transient sources of high-energy neutrinos thus remain interesting, with the potential for either neutrino clustering or multimessenger coincidence searches to lead to discovery of the first n+g transients., The authors thank David Thompson for helpful discussions. We gratefully acknowledge support from Penn State's Office of the Senior Vice President for Research, the Eberly College of Science, and the Penn State Institute for Gravitation and the Cosmos. This work was supported in part by the National Science Foundation under Grant No. PHY-1708146. K.M. is supported by the Alfred P. Sloan Foundation and by the National Science Foundation under Grant No. PHY-1620777. The authors acknowledge the financial support of the funding agencies: Centre National de la Recherche Scientifique (CNRS), Commissariat a l'energie atomique et aux energies alternatives (CEA), Commission Europeenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), IdEx program and UnivEarthS Labex program at Sorbonne Paris Cite (ANR-10-LABX-0023 and ANR-11-IDEX-0005-02), Labex OCEVU (ANR-11-LABX-0060) and the A*MIDEX project (ANR-11-IDEX-0001-02), Region Ile-de-France (DIM-ACAV), Region Alsace (contrat CPER), Region Provence-Alpes-Cote d'Azur, Departement du Var and Ville de La Seyne-sur-Mer, France; Bundesministerium fur Bildung und Forschung (BMBF), Germany; Istituto Nazionale di Fisica Nucleare (INFN), Italy; Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO), the Netherlands; Council of the President of the Russian Federation for young scientists and leading scientific schools supporting grants, Russia; Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI), Romania; Ministerio de Economia y Competitividad (MINECO): Plan Estatal de Investigacion (refs. FPA2015-65150-C3-1-P, -2-P and -3-P, (MINECO/FEDER)), Severo Ochoa Centre of Excellence and Red Consolider MultiDark (MINECO), and Prometeo and Grisolia programs (Generalitat Valenciana), Spain; Ministry of Higher Education, Scientific Research and Professional Training, Morocco. We also acknowledge the technical support of Ifremer, AIM and Foselev Marine for the sea operation and the CC-IN2P3 for the computing facilities. Software: Astropy (The Astropy Collaboration 2018), Matplotlib (Hunter 2007), HEASoft (Nasa High Energy Astrophysics Science Archive Research Center (Heasarc), 2014), HEALPix (Gorski et al. 2005), SciPy (Jones et al. 2001-2019)
Published: 2019

20. Joint Constraints on Galactic Diffuse Neutrino Emission from the ANTARES and IceCube Neutrino Telescopes

Author: Albert, A., André, M., Belhorma, B., Piattelli, P., Popa, V., Pradier, T., Quinn, L., Racca, C., Randazzo, N., Riccobene, G., Sánchez-Losa, A., Saldaña, M., Salvadori, I., Bertin, V., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schüssler, F., Spurio, M., Stolarczyk, Th., Taiuti, M., Tayalati, Y., Trovato, A., Vallage, B., Biagi, S., Elewyck, V. Van, Versari, F., Vivolo, D., Wilms, J., Zaborov, D., Zornoza, J. D., Zúñiga, J., Aartsen, M. G., Ackermann, Markus, Adams, J., Bormuth, R., Aguilar, J. A., Ahlers, M., Ahrens, M., Samarai, I. Al, Altmann, D., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Boumaaza, J., Auffenberg, J., Axani, S., Backes, P., Bagherpour, H., Bai, X., Barbano, A., Barron, J. P., Barwick, S. W., Baum, V., Bay, R., Bourret, S., Beatty, J. J., Tjus, J. Becker, Becker, K.-H., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Bouwhuis, M. C., Blot, S., Bohm, C., Börner, M., Bos, F., Böser, S., Botner, O., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Brânzaş, H., Brenzke, M., Bretz, H.-P., Bron, S., Brostean-Kaiser, J., Burgman, A., Busse, R. S., Carver, T., Cheung, E., Chirkin, D., Christov, A., Bruijn, R., Clark, K., Classen, L., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., Day, M., Brunner, J., de André, J. P. A. M., Clercq, C. De, DeLaunay, J. J., Dembinski, H., Deoskar, K., Ridder, S. De, Desiati, P., Vries, K. D. de, Wasseige, G. de, With, M. de, Anghinolfi, M., Busto, J., DeYoung, T., Díaz-Vélez, J. C., di Lorenzo, V., Dujmovic, H., Dumm, J. P., Dunkman, M., Dvorak, E., Eberhardt, B., Ehrhardt, T., Eichmann, B., Capone, A., Eller, P., Evenson, P. A., Fahey, S., Fazely, A. R., Felde, J., Filimonov, K., Finley, C., Franckowiak, A., Friedman, E., Fritz, A., Caramete, L., Gaisser, T. K., Gallagher, J., Ganster, E., Gerhardt, L., Ghorbani, K., Giang, W., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Carr, J., Grant, D., Griffith, Z., Haack, C., Hallgren, A., Halve, L., Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Helbing, K., Celli, S., Hellauer, R., Hickford, S., Hignight, J., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Chabab, M., Huber, M., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jacobi, Emanuel, Japaridze, G. S., Jeong, M., El Moursli, R. Cherkaoui, Jero, K., Jones, B. J. P., Kalaczynski, P., Kang, W., Kappes, A., Kappesser, D., Karg, T., Karle, A., Katz, U., Kauer, M., Chiarusi, T., Keivani, A., Kelley, J. L., Kheirandish, A., Kim, J., Kintscher, T., Kiryluk, J., Kittler, T., Klein, S. R., Koirala, R., Kolanoski, H., Circella, M., Köpke, L., Kopper, C., Kopper, S., Koschinsky, J. P., Koskinen, D. J., Kowalski, Marek, Krings, K., Kroll, M., Krückl, G., Kunwar, Samridha, Coelho, J. A. B., Kurahashi, N., Kyriacou, A., Labare, M., Lanfranchi, J. L., Larson, M. J., Lauber, F., Leonard, K., Leuermann, M., Liu, Q. R., Lohfink, E., Ardid, M., Coleiro, A., Mariscal, C. J. Lozano, Lu, L., Lünemann, J., Luszczak, W., Madsen, J., Maggi, G., Mahn, K. B. M., Makino, Y., Mancina, S., Maruyama, R., Colomer, M., Mase, K., Maunu, R., Meagher, K., Medici, M., Meier, M., Menne, T., Merino, G., Meures, T., Miarecki, S., Micallef, J., Coniglione, R., Momenté, G., Montaruli, T., Moore, R. W., Moulai, M., Nagai, R., Nahnhauer, R., Nakarmi, P., Naumann, U., Neer, G., Niederhausen, H., Costantini, H., Nowicki, S. C., Nygren, D. R., Pollmann, A. Obertacke, Olivas, A., O’Murchadha, A., O’Sullivan, E., Palczewski, T., Pandya, H., Pankova, D. V., Peiffer, P., Coyle, P., Pepper, J. A., de los Heros, C. Pérez, Pieloth, D., Pinat, E., Pizzuto, A., Plum, M., Price, P. B., Przybylski, G. T., Raab, C., Rameez, M., Creusot, A., Rauch, L., Rawlins, K., Rea, I. C., Reimann, R., Relethford, B., Resconi, E., Rhode, W., Richman, M., Robertson, S., Rongen, M., Díaz, A. F., Rott, C., Ruhe, T., Ryckbosch, D., Rysewyk, D., Safa, I., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Deschamps, A., Satalecka, K., Schaufel, M., Schlunder, P., Schmidt, T., Schneider, A., Schöneberg, S., Schumacher, L., Sclafani, S., Seckel, D., Distefano, C., Seunarine, S., Soedingrekso, J., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stasik, Alexander, Palma, I. Di, Stein, Robert, Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Strotjohann, N. L., Stuttard, T., Sullivan, G. W., Sutherland, M., Aubert, J.-J., Domi, A., Taboada, I., Tenholt, F., Ter-Antonyan, S., Terliuk, A., Tilav, S., Toale, P. A., Tobin, M. N., Tönnis, C., Toscano, S., Tosi, D., Donzaud, C., Tselengidou, M., Tung, C. F., Turcati, A., Turley, C. F., Ty, B., Unger, E., Elorrieta, M. A. Unland, Usner, M., Vandenbroucke, J., Driessche, W. Van, Dornic, D., Eijk, D. van, Eijndhoven, N. van, Vanheule, S., Santen, J. van, Vraeghe, M., Walck, C., Wallace, A., Wallraff, M., Wandler, F. D., Wandkowsky, N., Drouhin, D., Watson, T. B., Waza, A., Weaver, C., Weiss, M. J., Wendt, C., Werthebach, J., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wiebe, K., Eberl, T., Wiebusch, C. H., Wille, L., Williams, D. R., Wills, L., Wolf, M., Wood, J., Wood, T. R., Woolsey, E., Woschnagg, K., Wrede, G., Bojaddaini, I. El, Xu, D. L., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Yuan, T., Gaggero, D., Grasso, D., ANTARES Collaboration, Khayati, N. El, IceCube Collaboration, Elsässer, D., Enzenhöfer, A., Ettahiri, A., Aublin, J., Fassi, F., Felis, I., Fermani, P., Ferrara, G., Fusco, L., Gay, P., Glotin, H., Grégoire, T., Ruiz, R. Gracia, Graf, K., Avgitas, T., Hallmann, S., Haren, H. van, Heijboer, A. J., Hello, Y., Hernández-Rey, J. J., Hößl, J., Hofestädt, J., Illuminati, G., James, C. W., Jong, M. de, Baret, B., Jongen, M., Kadler, M., Kalekin, O., Khan-Chowdhury, N. R., Kouchner, A., Kreter, M., Kreykenbohm, I., Kulikovskiy, V., Lachaud, C., Barrios-Martí, J., Lahmann, R., Lefèvre, D., Leonora, E., Levi, G., Lotze, M., Loucatos, S., Marcelin, M., Margiotta, A., Marinelli, A., Martínez-Mora, J. A., Basa, S., Mele, R., Melis, K., Migliozzi, P., Moussa, A., Navas, S., Nezri, E., Nuñez, A., Organokov, M., Păvălaş, G. E., Pellegrino, C., Physics, Elementary Particle Physics, Vriendenkring VUB, Faculty of Sciences and Bioengineering Sciences, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Informatique et Systèmes (LIS), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Institut méditerranéen d'océanologie (MIO), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Département de Physique des Particules (ex SPP) (DPP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Groupe de Recherche en Physique des Hautes Energies (GRPHE), Institut Universitaire de Technologie de Colmar-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), ANTARES, IceCube, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Département de Physique des Particules (ex SPP) (DPhP), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-IUT de Colmar, Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Albert, A., Andre, M., Anghinolfi, M., Ardid, M., Aubert, J. -J., Aublin, J., Avgitas, T., Baret, B., Barrios-Marti, J., Basa, S., Belhorma, B., Bertin, V., Biagi, S., Bormuth, R., Boumaaza, J., Bourret, S., Bouwhuis, M. C., Branzas, H., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Celli, S., Chabab, M., El Moursli, R. C., Chiarusi, T., Circella, M., Coelho, J. A. B., Coleiro, A., Colomer, M., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., Diaz, A. F., Deschamps, A., Distefano, C., Palma, I. D., Domi, A., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., Bojaddaini, I. E., Khayati, N. E., Elsasser, D., Enzenhofer, A., Ettahiri, A., Fassi, F., Felis, I., Fermani, P., Ferrara, G., Fusco, L., Gay, P., Glotin, H., Gregoire, T., Ruiz, R. G., Graf, K., Hallmann, S., Haren, H. V., Heijboer, A. J., Hello, Y., Hernandez-Rey, J. J., Hossl, J., Hofestadt, J., Illuminati, G., James, C. W., Jong, M. D., Jongen, M., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N. R., Kouchner, A., Kreter, M., Kreykenbohm, I., Kulikovskiy, V., Lachaud, C., Lahmann, R., Lefevre, D., Leonora, E., Levi, G., Lotze, M., Loucatos, S., Marcelin, M., Margiotta, A., Marinelli, A., Martinez-Mora, J. A., Mele, R., Melis, K., Migliozzi, P., Moussa, A., Navas, S., Nezri, E., Nunez, A., Organokov, M., Pavalas, G. E., Pellegrino, C., Piattelli, P., Popa, V., Pradier, T., Quinn, L., Racca, C., Randazzo, N., Riccobene, G., Sanchez-Losa, A., Saldana, M., Salvadori, I., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schussler, F., Spurio, M., Stolarczyk, T., Taiuti, M., Tayalati, Y., Trovato, A., Vallage, B., Elewyck, V. V., Versari, F., Vivolo, D., Wilms, J., Zaborov, D., Zornoza, J. D., Zniga, J., Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Samarai, I. A., Altmann, D., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Arguelles, C., Auffenberg, J., Axani, S., Backes, P., Bagherpour, H., Bai, X., Barbano, A., Barron, J. P., Barwick, S. W., Baum, V., Bay, R., Beatty, J. J., Tjus, J. B., Becker, K. -H., Benzvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bohm, C., Borner, M., Bos, F., Boser, S., Botner, O., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Brenzke, M., Bretz, H. -P., Bron, S., Brostean-Kaiser, J., Burgman, A., Busse, R. S., Carver, T., Cheung, E., Chirkin, D., Christov, A., Clark, K., Classen, L., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., Day, M., De Andre, J. P. A. M., Clercq, C. D., Delaunay, J. J., Dembinski, H., Deoskar, K., Ridder, S. D., Desiati, P., Vries, K. D. D., Wasseige, G. D., With, M. D., Deyoung, T., Diaz-Velez, J. C., Di Lorenzo, V., Dujmovic, H., Dumm, J. P., Dunkman, M., Dvorak, E., Eberhardt, B., Ehrhardt, T., Eichmann, B., Eller, P., Evenson, P. A., Fahey, S., Fazely, A. R., Felde, J., Filimonov, K., Finley, C., Franckowiak, A., Friedman, E., Fritz, A., Gaisser, T. K., Gallagher, J., Ganster, E., Gerhardt, L., Ghorbani, K., Giang, W., Glauch, T., Glusenkamp, T., Goldschmidt, A., Gonzalez, J. G., Grant, D., Griffith, Z., Haack, C., Hallgren, A., Halve, L., Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Helbing, K., Hellauer, R., Hickford, S., Hignight, J., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Hultqvist, K., Hunnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jacobi, E., Japaridze, G. S., Jeong, M., Jero, K., Jones, B. J. P., Kalaczynski, P., Kang, W., Kappes, A., Kappesser, D., Karg, T., Karle, A., Kauer, M., Keivani, A., Kelley, J. L., Kheirandish, A., Kim, J., Kintscher, T., Kiryluk, J., Kittler, T., Klein, S. R., Koirala, R., Kolanoski, H., Kopke, L., Kopper, C., Kopper, S., Koschinsky, J. P., Koskinen, D. J., Kowalski, M., Krings, K., Kroll, M., Kruckl, G., Kunwar, S., Kurahashi, N., Kyriacou, A., Labare, M., Lanfranchi, J. L., Larson, M. J., Lauber, F., Leonard, K., Leuermann, M., Liu, Q. R., Lohfink, E., Mariscal, C. J. L., Lu, L., Lunemann, J., Luszczak, W., Madsen, J., Maggi, G., Mahn, K. B. M., Makino, Y., Mancina, S., Maruyama, R., Mase, K., Maunu, R., Meagher, K., Medici, M., Meier, M., Menne, T., Merino, G., Meures, T., Miarecki, S., Micallef, J., Momente, G., Montaruli, T., Moore, R. W., Moulai, M., Nagai, R., Nahnhauer, R., Nakarmi, P., Naumann, U., Neer, G., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Pollmann, A. O., Olivas, A., O'Murchadha, A., O'Sullivan, E., Palczewski, T., Pandya, H., Pankova, D. V., Peiffer, P., Pepper, J. A., De Los Heros, C. P., Pieloth, D., Pinat, E., Pizzuto, A., Plum, M., Price, P. B., Przybylski, G. T., Raab, C., Rameez, M., Rauch, L., Rawlins, K., Rea, I. C., Reimann, R., Relethford, B., Resconi, E., Rhode, W., Richman, M., Robertson, S., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Rysewyk, D., Safa, I., Herrera, S. E. S., Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Schaufel, M., Schlunder, P., Schmidt, T., Schneider, A., Schoneberg, S., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Soedingrekso, J., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stasik, A., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Stossl, A., Strotjohann, N. L., Stuttard, T., Sullivan, G. W., Sutherland, M., Taboada, I., Tenholt, F., Ter-Antonyan, S., Terliuk, A., Tilav, S., Toale, P. A., Tobin, M. N., Tonnis, C., Toscano, S., Tosi, D., Tselengidou, M., Tung, C. F., Turcati, A., Turley, C. F., Ty, B., Unger, E., Elorrieta, M. A. U., Usner, M., Vandenbroucke, J., Driessche, W. V., Eijk, D. V., Eijndhoven, N. V., Vanheule, S., Santen, J. V., Vraeghe, M., Walck, C., Wallace, A., Wallraff, M., Wandler, F. D., Wandkowsky, N., Watson, T. B., Waza, A., Weaver, C., Weiss, M. J., Wendt, C., Werthebach, J., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Wille, L., Williams, D. R., Wills, L., Wolf, M., Wood, J., Wood, T. R., Woolsey, E., Woschnagg, K., Wrede, G., Xu, D. L., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Yuan, T., Gaggero, D., Grasso, D., Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Centre National de la Recherche Scientifique (CNRS)-Université de Toulon (UTLN)-Aix Marseille Université (AMU)-Institut de Recherche pour le Développement (IRD), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut Universitaire de Technologie de Colmar, Centre Tecnològic de Vilanova i la Geltrú, Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques, KM3NeT (IHEF, IoP, FNWI), GRAPPA (ITFA, IoP, FNWI), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA), Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Toulon (UTLN), Albert, A, Andre, M, Anghinolfi, M, Ardid, M, Aubert, Jj, Aublin, J, Avgitas, T, Baret, B, Barrios-Marti, J, Basa, S, Belhorma, B, Bertin, V, Biagi, S, Bormuth, R, Boumaaza, J, Bourret, S, Bouwhuis, Mc, Branzas, H, Bruijn, R, Brunner, J, Busto, J, Capone, A, Caramete, L, Carr, J, Celli, S, Chabab, M, El Moursli, Rc, Chiarusi, T, Circella, M, Coelho, Jab, Coleiro, A, Colomer, M, Coniglione, R, Costantini, H, Coyle, P, Creusot, A, Diaz, Af, Deschamps, A, Distefano, C, Di Palma, I, Domi, A, Donzaud, C, Dornic, D, Drouhin, D, Eberl, T, El Bojaddaini, I, El Khayati, N, Elsasser, D, Enzenhofer, A, Ettahiri, A, Fassi, F, Felis, I, Fermani, P, Ferrara, G, Fusco, L, Gay, P, Glotin, H, Gregoire, T, Ruiz, Rg, Graf, K, Hallmann, S, van Haren, H, Heijboer, Aj, Hello, Y, Hernandez-Rey, Jj, Hossl, J, Hofestadt, J, Illuminati, G, James, Cw, de Jong, M, Jongen, M, Kadler, M, Kalekin, O, Katz, U, Khan-Chowdhury, Nr, Kouchner, A, Kreter, M, Kreykenbohm, I, Kulikovskiy, V, Lachaud, C, Lahmann, R, Lefevre, D, Leonora, E, Levi, G, Lotze, M, Loucatos, S, Marcelin, M, Margiotta, A, Marinelli, A, Martinez-Mora, Ja, Mele, R, Melis, K, Migliozzi, P, Moussa, A, Navas, S, Nezri, E, Nunez, A, Organokov, M, Pavalas, Ge, Pellegrino, C, Piattelli, P, Popa, V, Pradier, T, Quinn, L, Racca, C, Randazzo, N, Riccobene, G, Sanchez-Losa, A, Saldana, M, Salvadori, I, Samtleben, Dfe, Sanguineti, M, Sapienza, P, Schussler, F, Spurio, M, Stolarczyk, T, Taiuti, M, Tayalati, Y, Trovato, A, Vallage, B, Van Elewyck, V, Versari, F, Vivolo, D, Wilms, J, Zaborov, D, Zornoza, Jd, Zuniga, J, Aartsen, Mg, Ackermann, M, Adams, J, Aguilar, Ja, Ahlers, M, Ahrens, M, Al Samarai, I, Altmann, D, Andeen, K, Anderson, T, Ansseau, I, Anton, G, Arguelles, C, Auffenberg, J, Axani, S, Backes, P, Bagherpour, H, Bai, X, Barbano, A, Barron, Jp, Barwick, Sw, Baum, V, Bay, R, Beatty, Jj, Tjus, Jb, Becker, Kh, Benzvi, S, Berley, D, Bernardini, E, Besson, Dz, Binder, G, Bindig, D, Blaufuss, E, Blot, S, Bohm, C, Borner, M, Bos, F, Boser, S, Botner, O, Bourbeau, E, Bourbeau, J, Bradascio, F, Braun, J, Brenzke, M, Bretz, Hp, Bron, S, Brostean-Kaiser, J, Burgman, A, Busse, R, Carver, T, Cheung, E, Chirkin, D, Christov, A, Clark, K, Classen, L, Collin, Gh, Conrad, Jm, Coppin, P, Correa, P, Cowen, Df, Cross, R, Dave, P, Day, M, de Andre, Jpam, De Clercq, C, Delaunay, Jj, Dembinski, H, Deoskar, K, De Ridder, S, Desiati, P, de Vries, Kd, de Wasseige, G, de With, M, Deyoung, T, Diaz-Velez, Jc, di Lorenzo, V, Dujmovic, H, Dumm, Jp, Dunkman, M, Dvorak, E, Eberhardt, B, Ehrhardt, T, Eichmann, B, Eller, P, Evenson, Pa, Fahey, S, Fazely, Ar, Felde, J, Filimonov, K, Finley, C, Franckowiak, A, Friedman, E, Fritz, A, Gaisser, Tk, Gallagher, J, Ganster, E, Gerhardt, L, Ghorbani, K, Giang, W, Glauch, T, Glusenkamp, T, Goldschmidt, A, Gonzalez, Jg, Grant, D, Griffith, Z, Haack, C, Hallgren, A, Halve, L, Halzen, F, Hanson, K, Hebecker, D, Heereman, D, Helbing, K, Hellauer, R, Hickford, S, Hignight, J, Hill, Gc, Hoffman, Kd, Hoffmann, R, Hoinka, T, Hokanson-Fasig, B, Hoshina, K, Huang, F, Huber, M, Hultqvist, K, Hunnefeld, M, Hussain, R, In, S, Iovine, N, Ishihara, A, Jacobi, E, Japaridze, G, Jeong, M, Jero, K, Jones, Bjp, Kalaczynski, P, Kang, W, Kappes, A, Kappesser, D, Karg, T, Karle, A, Kauer, M, Keivani, A, Kelley, Jl, Kheirandish, A, Kim, J, Kintscher, T, Kiryluk, J, Kittler, T, Klein, Sr, Koirala, R, Kolanoski, H, Kopke, L, Kopper, C, Kopper, S, Koschinsky, Jp, Koskinen, Dj, Kowalski, M, Krings, K, Kroll, M, Kruckl, G, Kunwar, S, Kurahashi, N, Kyriacou, A, Labare, M, Lanfranchi, Jl, Larson, Mj, Lauber, F, Leonard, K, Leuermann, M, Liu, Qr, Lohfink, E, Mariscal, Cjl, Lu, L, Lunemann, J, Luszczak, W, Madsen, J, Maggi, G, Mahn, Kbm, Makino, Y, Mancina, S, Maruyama, R, Mase, K, Maunu, R, Meagher, K, Medici, M, Meier, M, Menne, T, Merino, G, Meures, T, Miarecki, S, Micallef, J, Momente, G, Montaruli, T, Moore, Rw, Moulai, M, Nagai, R, Nahnhauer, R, Nakarmi, P, Naumann, U, Neer, G, Niederhausen, H, Nowicki, Sc, Nygren, Dr, Pollmann, Ao, Olivas, A, O'Murchadha, A, O'Sullivan, E, Palczewski, T, Pandya, H, Pankova, Dv, Peiffer, P, Pepper, Ja, de los Heros, Cp, Pieloth, D, Pinat, E, Pizzuto, A, Plum, M, Price, Pb, Przybylski, Gt, Raab, C, Rameez, M, Rauch, L, Rawlins, K, Rea, Ic, Reimann, R, Relethford, B, Resconi, E, Rhode, W, Richman, M, Robertson, S, Rongen, M, Rott, C, Ruhe, T, Ryckbosch, D, Rysewyk, D, Safa, I, Herrera, Se, Sandrock, A, Sandroos, J, Santander, M, Sarkar, S, Satalecka, K, Schaufel, M, Schlunder, P, Schmidt, T, Schneider, A, Schoneberg, S, Schumacher, L, Sclafani, S, Seckel, D, Seunarine, S, Soedingrekso, J, Soldin, D, Song, M, Spiczak, Gm, Spiering, C, Stachurska, J, Stamatikos, M, Stanev, T, Stasik, A, Stein, R, Stettner, J, Steuer, A, Stezelberger, T, Stokstad, Rg, Stossl, A, Strotjohann, Nl, Stuttard, T, Sullivan, Gw, Sutherland, M, Taboada, I, Tenholt, F, Ter-Antonyan, S, Terliuk, A, Tilav, S, Toale, Pa, Tobin, Mn, Tonnis, C, Toscano, S, Tosi, D, Tselengidou, M, Tung, Cf, Turcati, A, Turley, Cf, Ty, B, Unger, E, Elorrieta, Mau, Usner, M, Vandenbroucke, J, Van Driessche, W, van Eijk, D, van Eijndhoven, N, Vanheule, S, van Santen, J, Vraeghe, M, Walck, C, Wallace, A, Wallraff, M, Wandler, Fd, Wandkowsky, N, Watson, Tb, Waza, A, Weaver, C, Weiss, Mj, Wendt, C, Werthebach, J, Westerhoff, S, Whelan, Bj, Whitehorn, N, Wiebe, K, Wiebusch, Ch, Wille, L, Williams, Dr, Wills, L, Wolf, M, Wood, J, Wood, Tr, Woolsey, E, Woschnagg, K, Wrede, G, Xu, Dl, Xu, Xw, Xu, Y, Yanez, Jp, Yodh, G, Yoshida, S, Yuan, T, Gaggero, D, Grasso, D, André, M., Aubert, J.-J., Barrios-Martí, J., Bouwhuis, M.C., Brânzaş, H., El Moursli, R. Cherkaoui, Coelho, J.A.B., Díaz, A.F., Palma, I. Di, Bojaddaini, I. El, Khayati, N. El, Elsässer, D., Enzenhöfer, A., Grégoire, T., Ruiz, R. Gracia, Haren, H. Van, Heijboer, A.J., Hernández-Rey, J.J., Hößl, J., Hofestädt, J., James, C.W., Jong, M. De, Khan-Chowdhury, N.R., Lefèvre, D., Martínez-Mora, J.A., Nuñez, A., Pǎvǎlaş, G.E., Sánchez-Losa, A., Saldaña, M., Samtleben, D.F.E., Schüssler, F., Stolarczyk, Th., Elewyck, V. Van, Zornoza, J.D., Zñiga, J., Aartsen, M.G., Aguilar, J.A., Samarai, I. Al, Argüelles, C., Barron, J.P., Barwick, S.W., Beatty, J.J., Tjus, J. Becker, Becker, K.-H., Besson, D.Z., Börner, M., Böser, S., Bretz, H.-P., Busse, R.S., Collin, G.H., Conrad, J.M., Cowen, D.F., De André, J.P.A.M., Clercq, C. De, Delaunay, J.J., Ridder, S. De, Vries, K. D. De, Wasseige, G. De, With, M. De, Díaz-Vélez, J.C., Dumm, J.P., Evenson, P.A., Fazely, A.R., Gaisser, T.K., Glüsenkamp, T., Gonzalez, J.G., Hill, G.C., Hoffman, K.D., Hünnefeld, M., Japaridze, G.S., Jones, B.J.P., Kelley, J.L., Klein, S.R., Köpke, L., Koschinsky, J.P., Koskinen, D.J., Krückl, G., Lanfranchi, J.L., Larson, M.J., Liu, Q.R., Mariscal, C. J. Lozano, Lünemann, J., Mahn, K.B.M., Momenté, G., Moore, R.W., Nowicki, S.C., Nygren, D.R., Pollmann, A. Obertacke, Pankova, D.V., Pepper, J.A., De Los Heros, C. Pérez, Price, P.B., Przybylski, G.T., Rea, I.C., Herrera, S. E. Sanchez, Schöneberg, S., Spiczak, G.M., Stokstad, R.G., Stößl, A., Strotjohann, N.L., Sullivan, G.W., Toale, P.A., Tobin, M.N., Tönnis, C., Tung, C.F., Turley, C.F., Elorrieta, M. A. Unland, Driessche, W. Van, Eijk, D. Van, Eijndhoven, N. Van, Santen, J. Van, Wandler, F.D., Watson, T.B., Weiss, M.J., Whelan, B.J., Wiebusch, C.H., Williams, D.R., Wood, T.R., Xu, D.L., Xu, X.W., Yanez, J.P., and COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])
Subjects: Astrofísica, Astrophysics, cosmic radiation: interaction, 7. Clean energy, 01 natural sciences, neutrino: flux, IceCube, Diffusion, neutrino, KASCADE, Raigs gamma, cosmic rays, diffusion, Galaxy: disk, gamma rays: diffuse background, neutrinos, Astronomy and Astrophysics, Space and Planetary Science, gamma ray: flux, 010303 astronomy & astrophysics, cosmic ray, Physics, radio wave, density, photomultiplier, ELEMENTAL GROUPS, cosmic radiation: spectrum, nucleon, Astrophysics::Instrumentation and Methods for Astrophysics, Model parameter, Physique [physics]/Astrophysique [astro-ph], astroparticle physics, cosmic radiation: galaxy, neutrino: flavor, Diffuse background, Neutrino, Nucleon, numerical calculations: Monte Carlo, Disk [Galaxy], CREAM, Astrophysics::High Energy Astrophysical Phenomena, energy spectrum, elementary particles, Joint likelihood, Cosmic ray, Astrophysics::Cosmology and Extragalactic Astrophysics, Radiation, GLAST, neutrino: production, diffuse background [gamma rays], gas, 0103 physical sciences, ENERGY-SPECTRA, Neutrins, Neutrinos, Cosmic rays, Astrophysics::Galaxy Astrophysics, cosmic radiation: production, ANTARES, 010308 nuclear & particles physics, Gamma rays, showers, Astronomy and Astrophysic, radiation mechanisms: non-thermal, radiation: Cherenkov, sensitivity, tracks, Neutrino astrophysics, messenger, Physics and Astronomy, 13. Climate action, Joint constraints, FISICA APLICADA, Física::Astronomia i astrofísica [Àrees temàtiques de la UPC], ddc:520, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: © 2018. The American Astronomical Society. All rights reserved. The existence of diffuse Galactic neutrino production is expected from cosmic-ray interactions with Galactic gas and radiation fields. Thus, neutrinos are a unique messenger offering the opportunity to test the products of Galactic cosmic-ray interactions up to energies of hundreds of TeV. Here we present a search for this production using ten years of Astronomy with a Neutrino Telescope and Abyss environmental RESearch (ANTARES) track and shower data, as well as seven years of IceCube track data. The data are combined into a joint likelihood test for neutrino emission according to the KRAg model assuming a 5 PeV per nucleon Galactic cosmic-ray cutoff. No significant excess is found. As a consequence, the limits presented in this Letter start constraining the model parameter space for Galactic cosmic-ray production and transport.
Published: 2018

21. The cosmic ray shadow of the Moon observed with the ANTARES neutrino telescope

Author: A. Albert, M. André, M. Anghinolfi, G. Anton, M. Ardid, J. -J. Aubert, J. Aublin, T. Avgitas, B. Baret, J. Barrios-Martít, S. Basa, B. Belhorma, V. Bertin, S. Biagi, R. Bormuth, J. Boumaaza, S. Bourret, M. C. Bouwhuis, H. Brânzaş, R. Bruijn, J. Brunner, J. Busto, A. Capone, L. Caramete, J. Carr, S. Celli, M. Chabab, R. Cherkaoui El Moursli, T. Chiarusi, M. Circella, J. A. B. Coelho, A. Coleiro, M. Colomer, R. Coniglione, H. Costantini, P. Coyle, A. Creusot, A. F. Díaz, A. Deschamps, C. Distefano, I. Di Palma, A. Domi, C. Donzaud, D. Dornic, D. Drouhin, T. Eberl, I. El Bojaddaini, N. El Khayati, D. Elsässer, A. Enzenhöfer, A. Ettahiri, F. Fassi, I. Felis, P. Fermani, G. Ferrara, L. A. Fusco, P. Gay, H. Glotin, T. Grégoire, R. Gracia Ruiz, K. Graf, S. Hallmann, H. van Haren, A. J. Heijboer, Y. Hello, J. J. Hernández-Rey, J. Hößl, J. Hofestädt, G. Illuminati, M. de Jong, M. Jongen, M. Kadler, O. Kalekin, U. Katz, N. R. Khan-Chowdhury, A. Kouchner, M. Kreter, I. Kreykenbohm, V. Kulikovskiy, C. Lachaud, R. Lahmann, D. Lefèvre, E. Leonora, G. Levi, M. Lotze, S. Loucatos, M. Marcelin, A. Margiotta, A. Marinelli, J. A. Martínez-Mora, R. Mele, K. Melis, P. Migliozzi, A. Moussa, S. Navas, E. Nezri, A. Nuñez, M. Organokov, G. E. Păvălaş, C. Pellegrino, P. Piattelli, V. Popa, T. Pradier, L. Quinn, C. Racca, N. Randazzo, G. Riccobene, A. Sánchez-Losa, M. Saldaña, I. Salvadori, D. F. E. Samtleben, M. Sanguineti, P. Sapienza, F. Schüssler, M. Spurio, Th. Stolarczyk, M. Taiuti, Y. Tayalati, A. Trovato, B. Vallage, V. Van Elewyck, F. Versari, D. Vivolo, J. Wilms, D. Zaborov, J. D. Zornoza, J. Zúñiga, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Informatique et Systèmes (LIS), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Institut méditerranéen d'océanologie (MIO), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Groupe de Recherche en Physique des Hautes Energies (GRPHE), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-IUT de Colmar, Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), ANTARES, Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Observatoire de la Côte d'Azur (OCA), Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de Technologie de Colmar-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut Universitaire de Technologie de Colmar, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-Université de Toulon (UTLN)-Aix Marseille Université (AMU)-Institut de Recherche pour le Développement (IRD), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Toulon (UTLN), KM3NeT (IHEF, IoP, FNWI), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre Tecnològic de Vilanova i la Geltrú, Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques, Albert, A., Andre, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J. -J., Aublin, J., Avgitas, T., Baret, B., Barrios-Martit, J., Basa, S., Belhorma, B., Bertin, V., Biagi, S., Bormuth, R., Boumaaza, J., Bourret, S., Bouwhuis, M. C., Branzas, H., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Celli, S., Chabab, M., Moursli, R. C. E., Chiarusi, T., Circella, M., Coelho, J. A. B., Coleiro, A., Colomer, M., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., Diaz, A. F., Deschamps, A., Distefano, C., Palma, I. D., Domi, A., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., Bojaddaini, I. E., Khayati, N. E., Elsasser, D., Enzenhofer, A., Ettahiri, A., Fassi, F., Felis, I., Fermani, P., Ferrara, G., Fusco, L. A., Gay, P., Glotin, H., Gregoire, T., Ruiz, R. G., Graf, K., Hallmann, S., van Haren, H., Heijboer, A. J., Hello, Y., Hernandez-Rey, J. J., Hossl, J., Hofestadt, J., Illuminati, G., de Jong, M., Jongen, M., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N. R., Kouchner, A., Kreter, M., Kreykenbohm, I., Kulikovskiy, V., Lachaud, C., Lahmann, R., Lefevre, D., Leonora, E., Levi, G., Lotze, M., Loucatos, S., Marcelin, M., Margiotta, A., Marinelli, A., Martinez-Mora, J. A., Mele, R., Melis, K., Migliozzi, P., Moussa, A., Navas, S., Nezri, E., Nunez, A., Organokov, M., Pavalas, G. E., Pellegrino, C., Piattelli, P., Popa, V., Pradier, T., Quinn, L., Racca, C., Randazzo, N., Riccobene, G., Sanchez-Losa, A., Saldana, M., Salvadori, I., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schussler, F., Spurio, M., Stolarczyk, T., Taiuti, M., Tayalati, Y., Trovato, A., Vallage, B., Van Elewyck, V., Versari, F., Vivolo, D., Wilms, J., Zaborov, D., Zornoza, J. D., Zuniga, J., Albert, A, Andre, M, Anghinolfi, M, Anton, G, Ardid, M, Aubert, Jj, Aublin, J, Avgitas, T, Baret, B, Barrios-Martit, J, Basa, S, Belhorma, B, Bertin, V, Biagi, S, Bormuth, R, Boumaaza, J, Bourret, S, Bouwhuis, Mc, Branzas, H, Bruijn, R, Brunner, J, Busto, J, Capone, A, Caramete, L, Carr, J, Celli, S, Chabab, M, El Moursli, Rc, Chiarusi, T, Circella, M, Coelho, Jab, Coleiro, A, Colomer, M, Coniglione, R, Costantini, H, Coyle, P, Creusot, A, Diaz, Af, Deschamps, A, Distefano, C, Palma, I, Domi, A, Donzaud, C, Dornic, D, Drouhin, D, Eberl, T, Bojaddaini, I, Khayati, N, Elsaesser, D, Enzenhoefer, A, Ettahiri, A, Fassi, F, Felis, I, Fermani, P, Ferrara, G, Fusco, La, Gay, P, Glotin, H, Gregoire, T, Ruiz, Rg, Graf, K, Hallmann, S, Haren, H, Heijboer, Aj, Hello, Y, Hernandez-Rey, Jj, Hoessl, J, Hofestaedt, J, Illuminati, G, Jong, M, Jongen, M, Kadler, M, Kalekin, O, Katz, U, Khan-Chowdhury, Nr, Kouchner, A, Kreter, M, Kreykenbohm, I, Kulikovskiy, V, Lachaud, C, Lahmann, R, Lefevre, D, Leonora, E, Levi, G, Lotze, M, Loucatos, S, Marcelin, M, Margiotta, A, Marinelli, A, Martinez-Mora, Ja, Mele, R, Melis, K, Migliozzi, P, Moussa, A, Navas, S, Nezri, E, Nunez, A, Organokov, M, Pavalas, Ge, Pellegrino, C, Piattelli, P, Popa, V, Pradier, T, Quinn, L, Racca, C, Randazzo, N, Riccobene, G, Sanchez-Losa, A, Saldana, M, Salvadori, I, Samtleben, Dfe, Sanguineti, M, Sapienza, P, Schussler, F, Spurio, M, Stolarczyk, T, Taiuti, M, Tayalati, Y, Trovato, A, Vallage, B, Elewyck, V, Versari, F, Vivolo, D, Wilms, J, Zaborov, D, Zornoza, Jd, Zuniga, J, André, M., Aubert, J.-J., Barrios-Martít, J., Bouwhuis, M.C., Brânzaş, H., Moursli, R. Cherkaoui El, Coelho, J.A.B., Díaz, A.F., Palma, I. Di, Bojaddaini, I. El, Khayati, N. El, Elsässer, D., Enzenhöfer, A., Fusco, L.A., Grégoire, T., Ruiz, R. Gracia, Heijboer, A.J., Hernández-Rey, J.J., Hößl, J., Hofestädt, J., Khan-Chowdhury, N.R., Lefèvre, D., Martínez-Mora, J.A., Nuñez, A., Păvălaş, G.E., Sánchez-Losa, A., Saldaña, M., Samtleben, D.F.E., Schüssler, F., Stolarczyk, Th., Zornoza, J.D., and Zúñiga, J.
Subjects: Astrofísica, Physics and Astronomy (miscellaneous), Physics::Instrumentation and Detectors, Planets, Astrophysics, shadowing: lunar, 01 natural sciences, law.invention, Astronomical observatories, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), law, Shadow, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], cosmic ray, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), astro-ph.HE, astro-ph.IM, Detector, Moon shadow, Astrophysics::Instrumentation and Methods for Astrophysics, muon: atmosphere, Physique [physics]/Astrophysique [astro-ph], neutrino: detector, Astrophysics::Earth and Planetary Astrophysics, Neutrino, Observatoris astronòmics, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, performance, Regular Article - Experimental Physics, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Context (language use), Cosmic ray, lcsh:Astrophysics, Computer Science::Digital Libraries, Lluna, Telescope, neutrino astronomy, cosmic rays, 0103 physical sciences, lcsh:QB460-466, ANTARES, neutrino telescope, Angular resolution, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, Neutrins, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Neutrinos, Planetes, cosmic radiation: absorption, 010306 general physics, Engineering (miscellaneous), muon: flux, Instrumentation and Methods for Astrophysics (astro-ph.IM), Muon, Telescopis, Antares neutrino Telescope, 010308 nuclear & particles physics, Astronomy, showers, Physique [physics]/Physique des Hautes Energies - Expérience [hep-ex], Neutrino astrophysics, Point like neutrino sources, angular resolution, Física::Astronomia i astrofísica [Àrees temàtiques de la UPC], FISICA APLICADA, lcsh:QC770-798, High Energy Physics::Experiment, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], statistical, Telescopes
Abstract: [EN] One of the main objectives of the ANTARES telescope is the search for point-like neutrino sources. Both the pointing accuracy and the angular resolution of the detector are important in this context and a reliable way to evaluate this performance is needed. In order to measure the pointing accuracy of the detector, one possibility is to study the shadow of the Moon, i.e. the de¿cit of the atmospheric muon ¿ux from the direction of the Moon induced by the absorption of cosmic rays. Analysing the data taken between 2007 and 2016, the Moon shadow is observed with 3.5¿ statistical signi¿cance. The detector angular resolution for downward-going muons is 0.73¿ ±0.14¿. The resulting pointing performance is consistent with the expectations. An independent check of the telescope pointing accuracy is realised with the data collected by a shower array detector onboard of a ship temporarily moving around the ANTARES location., The authors acknowledge the financial support of the funding agencies: Centre National de la Recherche Scientifique (CNRS), Commissariat a l'energie atomique et aux energies alternatives (CEA), Commission Europeenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), IdEx program and UnivEarthS Labex program at Sorbonne Paris Cite (ANR-10-LABX-0023 and ANR-11-IDEX-0005-02), Labex OCEVU (ANR-11-LABX-0060) and the A*MIDEX project (ANR-11-IDEX-0001-02), Region Ile-de-France (DIM-ACAV), Region Alsace (contrat CPER), Region Provence-Allies-Cote d'Azur, Departement du Var and Ville de La Seyne-sur-Mer, France; Bundesministerium fin Bildung and Forschung (BMBF), Germany; Istituto Naziona-le di Fisica Nucleare (INFN), Italy; Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO), the Netherlands; Council of the President of the Russian Federation for young scientists and leading scientific schools supporting grants, Russia; National Authority for Scientific Research (ANCS), Romania; Ministerio de Economia y Competitividad (MINE-CO): Plan Estatal de Investigacion (refs. FPA2015-65150-C3-1-P, -2-P and -3-P, (MINECO/FEDER)), Severn Ochoa Centre of Excellence and MultiDark Consolider (MINECO), and Prometeo and Grisolia programs (Generalitat Valencia-na), Spain; Ministry of Higher Education, Scientific Research and Professional Training, Morocco. We also acknowledge the technical support of Ifremer, AIM and Foselev Marine for the sea operation and the CC-IN2P3 for the computing facilities.
Published: 2018

22. A phase 2, multicenter, open-label study of anti-LAG-3 ieramilimab in combination with anti-PD-1 spartalizumab in patients with advanced solid malignancies.

Author: Lin CC, Garralda E, Schöffski P, Hong DS, Siu LL, Martin M, Maur M, Hui R, Soo RA, Chiu J, Zhang T, Ma B, Kyi C, Tan DS, Cassier PA, Sarantopoulos J, Weickhardt A, Carvajal RD, Spratlin J, Esaki T, Rolland F, Akerley W, Deschler-Baier B, Rispoli L, Samant TS, Chowdhury NR, Gusenleitner D, Kwak EL, Askoxylakis V, and De Braud F
Subjects: Humans, Antibodies, Monoclonal therapeutic use, Immune Checkpoint Inhibitors therapeutic use, Biomarkers, Fatigue chemically induced, Fatigue drug therapy, Carcinoma, Non-Small-Cell Lung drug therapy, Melanoma drug therapy, Melanoma genetics, Carcinoma, Renal Cell drug therapy, Lung Neoplasms drug therapy, Kidney Neoplasms drug therapy, Exanthema chemically induced, Exanthema drug therapy
Abstract: Ieramilimab, a humanized anti-LAG-3 monoclonal antibody, was well tolerated in combination with the anti-PD-1 antibody spartalizumab in a phase 1 study. This phase 2 study aimed to further investigate the efficacy and safety of combination treatment in patients with selected advanced (locally advanced or metastatic) solid malignancies. Eligible patients with non-small cell lung cancer (NSCLC), melanoma, renal cell carcinoma (RCC), mesothelioma, and triple-negative breast cancer (TNBC) were grouped depending on prior anti-PD-1/L1 therapy (anti-PD-1/L1 naive or anti-PD-1/L1 pretreated). Patients received ieramilimab (400 mg) followed by spartalizumab (300 mg) every 3 weeks. The primary endpoint was objective response rate (ORR), along with safety, pharmacokinetics, and biomarker assessments. Of 235 patients, 142 were naive to anti-PD-1/L1 and 93 were pretreated with anti-PD-1/L1 antibodies. Durable responses (>24 months) were seen across all indications for patients naive to anti-PD-1/L1 and in melanoma and RCC patients pretreated with anti-PD1/L1. The most frequent study drug-related AEs were pruritus (15.5%), fatigue (10.6%), and rash (10.6%) in patients naive to anti-PD-1/L1 and fatigue (18.3%), rash (14.0%), and nausea (10.8%) in anti-PD-1/L1 pretreated patients. Biomarker assessment indicated higher expression of T-cell-inflamed gene signature at baseline among responding patients. Response to treatment was durable (>24 months) in some patients across all enrolled indications, and safety findings were in accordance with previous and current studies exploring LAG-3/PD-1 blockade., Competing Interests: CCL reports consulting fees from AbbVie, Blueprint Medicines, Boehringer Ingelheim, Bristol Myers Squibb (BMS), Daiichi-Sankyo, Merck KGaA, Novartis, PharmaEngine; payment or honoraria from Eli Lilly, Novartis, and Roche; and support for attending meetings or travel from BeiGene, Daiichi-Sankyo, and Eli Lilly. EG reports grants or contracts from Novartis, Roche, Thermo Fisher, AstraZeneca, Taiho, and BeiGene; payment or honoraria from Roche, Genentech, F. Hoffmann-La Roche, Ellipses Pharma, Neomed Therapeutics Inc, Boehringer Ingelheim, Janssen Global Services, SeaGen, Alkermes, Thermo Fisher, BMS, MabDicovery, Anaveon, F-Star Therapeutics, Hengrui; participated on data safety monitoring board or advisory board for Roche, Genentech, Boehringer Ingelheim, Janssen Global Services, Thermo Fisher, Anaveon, MabDiscovery, Novartis and Lilly; and serves as PI or Co-PI for Affimed Gmbh. Amgen SA, Anaveon AG, AstraZeneca AB, Biontech Gmbh, Catalym Gmbh, Cytomx, F. Hoffmann-La Roche Ltd, F-Star Beta Limited, Genentech Inc, Genmab B.V, Hutchison Medipharma Limited, Icon, Imcheck Therapeutics, Immunocore Ltd, Janssen-Cilag SA, Medimmune Llc, Merck KGaA, Novartis Farmacéutica SA, Peptomyc, Ribon Therapeutics, Roche Farma SA, Seattle Genetics Inc, Symphogen A/S, Taiho Pharma Usa Inc PS reports grants or contracts from CoBioRes NV, Eisai, G1 Therapeutics, PharmaMar, Genmab, Merck, Sartar Therapeutics, ONA therapeutics; honoraria from Blueprint Medicines; and consulting fees from Deciphera, Ellipses Pharma, Blueprint Medicines, Transgene, Exelixis, Boehringer Ingelheim, Studiecentrum voor Kernenergie, SQZ biotechnology, CRT Pioneer Fund LP, Adcendo, PharmaMar, Merck Healthcare KGaA, Ysios Capital. DSH reports grants or contracts from AbbVie, Adaptimmune, Aldi-Norte, Amgen, AstraZeneca, Bayer, BMS, Daiichi-Sankyo, Deciphera, Eisai, Erasca, Fate Therapeutics, Genentech, Genmab, Infinity, Kite, Kyowa, Lilly, LOXO, Merck, Medimmune, Mirati, Mologen, Navier, NCI-CTEP, Novartis, Numab, Pfizer, Pyramid Bio, SeaGen, Takeda, Turning Point Therapeutics, Verstatem, and VM Oncology; travel, accommodation, expenses from Bayer, Genmab, and Telperian; consulting fee from Adaptimmune, Alpha Insights, Acuta, Alkermes, Amgen, Aumbiosciences, Atheneum, Axiom, Barclays, Baxter, Bayer, Boxer Capital, BridgeBio, CDR-life AG, COR2ed, COG, Ecor1, Genentech, Gilead, GLG, Group H, Guidepoint, HCW Precision, Immunogen, Infinity, Janssen, Liberium, Medscape, Numab, Oncologia Brasil, Pfizer, Pharma Intelligence, POET Congress, Prime Oncology, Seattle Genetics, ST Cube, Takeda, Tavistock, Trieza Therapeutics, Turning Point, WebMD, and Ziopharm; and other ownership interests for OncoResponse (founder) and Telperian Inc (advisor). LLS reports stock ownership or equity in Agios (spouse); leadership in Treadwell Therapeutics (spouse is co-founder); and consulting fee/advisory board for Merck, Pfizer, AstraZeneca, Roche, Symphogen, GSK, Voronoi, Treadwell Therapeutics, Arvinas, Tessa, Navire, Relay, Rubius, Janpix, Daiichi-Sankyo, Coherus, Amgen, and Marengo; grant/research support (clinical trials for institution) for Novartis, BMS, Pfizer, Boerhinger-Ingelheim, GlaxoSmithKline, Roche/Genentech, Karyopharm, AstraZeneca/Medimmune, Merck, Celgene, Astellas, Bayer, AbbVie, Amgen, Symphogen, Intensity Therapeutics, Mirati, Shattucks, and Avid. MigM reports honoraria from SeaGen, Lilly, AstraZeneca, Pfizer, Daiichi-Sankyo, Roche; consulting fees from Roche, Novartis, AstraZeneca, Daiichi-Sankyo, SeaGen, Lilly, Sanofi; advisory board of Novartis and holds leadership roles in GEICAM (Board of Directors), TRIO. RH reports grants and contacts for clinical trials for institution from AstraZeneca, BMS, Corvus, Eli Lilly, MSD, Novartis, Olema, Oncosec, Roche, SeaGen; honoraria from AstraZeneca, Eli Lilly, MSD, Novartis, Pfizer, Roche; participates in advisory board of AstraZeneca, BMS, Eisai, Eli Lilly, Merck, MSD, Novartis, OncoSec, Pfizer, Roche, SeaGen. RAS reports grants from AstraZeneca and Boehringer Ingelheim, and personal fees from AstraZeneca, BMS, Boehringer Ingelheim, Eli Lilly Merck, Novartis, Pfizer, Roche, Taiho, Takeda, Yuhan, Amgen, Bayer, Puma. TZ reports grants from Genentech Roche, OmniSeq, SeaGen, PGDx, Janssen, AstraZeneca, Pfizer, AbbVie/StemcentrX, Merck, Regeneron, Mirati Therapeutics, Novartis, Merrimack; consulting fees from Genentech Roche, Eli Lilly, Bayer, QED Therapeutics, Eisai, Calithera, Aveo Pharmaceuticals, Amgen, BMS, Dendreaon, Sanofi-Aventis, Janssen, AstraZeneca, Pfizer, Merck, Exelixis; honoraria from MJH Associates, Aptitude Health, PlatformQ, Integrity CE, Vaniam Group, PeerView, and Novartis; travel support from SUO, Kidney Cancer Association, and KCCure; and leadership role in NCI GU Steering Renal Task force, KCA Medical Steering committee, and KCCure Scientific advisory board. BM reports grant from Health and Medical Research Fund, Merck Serono, Boehringer Ingelheim Inc; consulting fees from Viracta therapeutics and Y-Biologics; honoraria from MSD, Novartis, Merck, Y-Biologics, Springer, Elsevier, Daiichi, Taiho, and Pierra Fabre; holds leadership roles in ethics committee of NTEC-CUHK, ESMO Asia 2020 and ESMO 2022 (Track Chair – Paris, Singapore), ASCO 2020 (Session chair), and ESMO Asia 2019 (Co-Chair). CK reports research funding from BMS, Merus, and Gritstone Oncology. DT reports honoraria and consulting/advisory roles for Merck, Pfizer, Novartis, Boehringer Ingelheim, Roche, and Takeda; consulting/advisory roles for Bayer, AstraZeneca, Eli Lilly, and GlaxoSmithKline; and research funding for Novartis, AstraZeneca, GlaxoSmithKline, Bayer, Pfizer, and Amgen. PAC reports research funding from AbbVie, Adlai Nortye, Alligator, Amgen, AstraZeneca, Blueprint Medicines, Boston, Bristol Myers Squibb, Celgene, Debio Pharm, Dragonfly, Exelixis, GlaxoSmithKline, Innate Pharma, Janssen, Eli Lilly, Loxo, Molecular Partners, MSD, Novartis, OSE Pharma, Relay, Roche/Genentech, Sotio, Taiho Pharmaceutical, Toray Industries, Transgene, and Turning Point Therapeutics; personal fees from AstraZeneca, Amgen, Merck Serono, Novartis, and Roche/Genentech; nonfinancial research support from AstraZeneca, Debio Pharm, MSD, Novartis, Plexxikon, and Roche/Genentech; and travel accommodation from BMS, MSD, and NETRIS Pharma. JS reports consulting/advisory roles for Astellas Pharma, AstraZeneca/MedImmune, Bayer, Eisai, Roche/Genentech, Pfizer, Immunocore, SeaGen, Novartis, Sun Pharma, EMD Serono, Amgen, Bristol-Myer Squib, Flugent Therapeutics, Exelixis, Merck, Takeda, and Array BioPharma. AW received research grants from Merck and BMS; consulting fees from Ipsen, Astella, BMS; and honoraria from Ipsen, Pfizer, BMS. RDC received research funding from Amgen, Astellis, AstraZeneca, BMS, Corvus, Ideaya, Immunocore, Iovance, Merck, Mirati, Novartis, Pfizer, Plexxikon, Regeneron, Roche/Genentech; consulting fees from Alkermes, BMS, Castle Biosciences, Eisai, Ideaya, Immunocore, InxMed, Iovance, Merck, Novartis, Oncosec, Pierre Fabre, PureTech Health, Regeneron, Sanofi Genzyme, Sorrento Therapeutics, Trisalus; participated in data safety monitoring or advisory board of Aura Biosciences, Chimeron, and Rgenix; and stocks in Aura Biosciences, Chimeron, and Rgenix. TE reports grants for MSD, Novartis, Dainipon Sumitomo, Ono, Daiichi-Sankyo, Astellas, Astellas Amgen Biopharma, Parexel, Chugai, Quintiles, Syneos Health, Pfizer, IQVIA; and honoraria from MSD, Ono, Daiichi-Sankyo, Eli Lilly, Taiho, Chugai, and Sanofi. FR reports consulting fees from BMS and MSD; honoraria from Merck KGaA. FDB reports consulting fees from NMS Nerviano, Menarini, AstraZeneca, Incyte; honoraria from BMS, Merck Group, MDS, Pfizer, Servier, Sanofi, Roche, Amgen, Incyte; travel support from Roche; and participated in advisory board of Pierre Fabre, AstraZeneca, MSD Serono, BMS, Roche, Sanofi, Novartis. LR is employee of Novartis. MicM, JC, JS, WA, BDB reports no conflicts of interest. TS, NRC, DG, EK and VA were employees of Novartis at the time of study conduct. EK and VA report stocks from Novartis., (© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.)
Published: 2023
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23. Significance of the prime factors regulating arsenic toxicity and associated health risk: a hypothesis-based investigation in a critically exposed population of West Bengal, India.

Author: Das A, Joardar M, Chowdhury NR, Mridha D, De A, Majumder S, Das J, Majumdar KK, and Roychowdhury T
Subjects: Adult, Child, Adolescent, Humans, India epidemiology, Biomarkers, Water Supply, Arsenic toxicity, Arsenic analysis, Drinking Water analysis, Water Pollutants, Chemical toxicity, Water Pollutants, Chemical analysis, Arsenic Poisoning epidemiology
Abstract: The suffering from arsenic toxicity is a long-standing concern in Asian countries. The role of the key factors (arsenic intake, age and sex) regulating arsenic toxicity is aimed to evaluate for a severely exposed population from Murshidabad district, West Bengal. Mean arsenic concentrations in drinking water supplied through tube well, Sajaldhara treatment plant and pipeline were observed as 208, 27 and 54 µg/l, respectively. Urinary arsenic concentration had been observed as < 3-42.1, < 3-56.2 and < 3-80 µg/l in children, teenagers and adults, respectively. Mean concentrations of hair and nail arsenic were found to be 0.84 and 2.38 mg/kg; 3.07 and 6.18 mg/kg; and 4.41 and 9.07 mg/kg, respectively, for the studied age-groups. Water arsenic was found to be associated with hair and nail (r = 0.57 and 0.60), higher than urine (r = 0.37). Arsenic deposition in biomarkers appeared to be dependent on age; however, it is independent of sex. Principal component analysis showed a direct relationship between dietary intake of arsenic and chronic biomarkers. Nail was proved as the most fitted biomarker of arsenic toxicity by Dunn's post hoc test. Monte Carlo sensitivity analysis and cluster analysis showed that the most significant factor regulating health risk is 'concentration of arsenic' than 'exposure duration', 'body weight' and 'intake rate'. The contribution of arsenic concentration towards calculated health risk was highest in teenagers (45.5-61.2%), followed by adults (47.8-49%) and children (21-27.6%). Regular and sufficient access to arsenic-safe drinking water is an immediate need for the affected population., (© 2022. The Author(s), under exclusive licence to Springer Nature B.V.)
Published: 2023
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24. Different levels of arsenic exposure through cooked rice and its associated benefit-risk assessment from rural and urban populations of West Bengal, India: a probabilistic approach with sensitivity analysis.

Author: Joardar M, Mukherjee P, Das A, Mridha D, De A, Chowdhury NR, Majumder S, Ghosh S, Das J, Alam MR, Rahman MM, and Roychowdhury T
Subjects: Adult, Child, Male, Female, Humans, Urban Population, Environmental Exposure analysis, Food Contamination analysis, Risk Assessment, India, Arsenic analysis, Oryza
Abstract: Rice arsenic (As) contamination and its consumption poses a significant health threat to humans. The present study focuses on the contribution of arsenic, micronutrients, and associated benefit-risk assessment through cooked rice from rural (exposed and control) and urban (apparently control) populations. The mean decreased percentages of As from uncooked to cooked rice for exposed (Gaighata), apparently control (Kolkata), and control (Pingla) areas are 73.8, 78.5, and 61.3%, respectively. The margin of exposure through cooked rice (MoE cooked rice ) < 1 signifies the existence of health risk for all the studied exposed and control age groups. The respective contributions of iAs (inorganic arsenic) in uncooked and cooked rice are nearly 96.6, 94.7, and 100% and 92.2, 90.2, and 94.2% from exposed, apparently control, and control areas. LCR analysis for the exposed, apparently control, and control populations (adult male: 2.1 × 10 -3 , 2.8 × 10 -4 , 4.7 × 10 -4 ; adult female: 1.9 × 10 -3 , 2.1 × 10 -4 , 4.4 × 10 -4 ; and children: 5.8 × 10 -4 , 4.9 × 10 -5 , 1.1 × 10 -4 ) through cooked rice is higher than the recommended value, i.e., 1 × 10 -6 , respectively, whereas HQ > 1 has been observed for all age groups from the exposed area and adult male group from the control area. Adults and children from rural area showed that ingestion rate (IR) and concentration are the respective influencing factors towards cooked rice As, whereas IR is solely responsible for all age groups from urban area. A vital suggestion is to reduce the IR of cooked rice for control population to avoid the As-induced health risks. The average intake (μg/day) of micronutrients is in the order of Zn > Se for all the studied populations and Se intake is lower for the exposed population (53.9) compared to the apparently control (140) and control (208) populations. Benefit-risk assessment supported that the Se-rich values in cooked rice are effective in avoiding the toxic effect and potential risk from the associated metal (As)., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Published: 2023
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25. Co-expression of diurnal and ultradian rhythms in the plasma metabolome of common voles (Microtus arvalis).

Author: Psomas A, Chowdhury NR, Middleton B, Winsky-Sommerer R, Skene DJ, Gerkema MP, and van der Veen DR
Subjects: Animals, Metabolome, Circadian Rhythm, Amino Acids, Arvicolinae, Ultradian Rhythm
Abstract: Metabolic rhythms include rapid, ultradian (hourly) dynamics, but it remains unclear what their relationship to circadian metabolic rhythms is, and what role meal timing plays in coordinating these ultradian rhythms in metabolism. Here, we characterized widespread ultradian rhythms under ad libitum feeding conditions in the plasma metabolome of the vole, the gold standard animal model for behavioral ultradian rhythms, naturally expressing ~2-h foraging rhythms throughout the day and night. These ultradian metabolite rhythms co-expressed with diurnal 24-h rhythms in the same metabolites and did not align with food intake patterns. Specifically, under light-dark entrained conditions we showed twice daily entrainment of phase and period of ultradian behavioral rhythms associated with phase adjustment of the ultradian cycle around the light-dark and dark-light transitions. These ultradian activity patterns also drove an ultradian feeding pattern. We used a unique approach to map this behavioral activity/feeding status to high temporal resolution (every 90 min) measures of plasma metabolite profiles across the 24-h light-dark cycle. A total of 148 known metabolites were detected in vole plasma. Supervised, discriminant analysis did not group metabolite concentration by feeding status, instead, unsupervised clustering of metabolite time courses revealed clusters of metabolites that exhibited significant ultradian rhythms with periods different from the feeding cycle. Two clusters with dissimilar ultradian dynamics, one lipid-enriched (period = 3.4 h) and one amino acid-enriched (period = 4.1 h), both showed co-expression with diurnal cycles. A third cluster solely comprised of glycerophospholipids (specifically ether-linked phosphatidylcholines) expressed an 11.9 h ultradian rhythm without co-expressed diurnal rhythmicity. Our findings show coordinated co-expression of diurnal metabolic rhythms with rapid dynamics in feeding and metabolism. These findings reveal that ultradian rhythms are integral to biological timing of metabolic regulation, and will be important in interpreting the impact of circadian desynchrony and meal timing on metabolic rhythms., (© 2023 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.)
Published: 2023
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26. Metabolomic Analysis of Plasma in Huntington's Disease Transgenic Sheep (Ovis aries) Reveals Progressive Circadian Rhythm Dysregulation.

Author: Spick M, Hancox TPM, Chowdhury NR, Middleton B, Skene DJ, and Morton AJ
Subjects: Animals, Sheep, Humans, Female, Child, Preschool, Child, Animals, Genetically Modified, Amino Acids, Circadian Rhythm, Disease Models, Animal, Sheep, Domestic, Huntington Disease complications
Abstract: Background: Metabolic abnormalities have long been predicted in Huntington's disease (HD) but remain poorly characterized. Chronobiological dysregulation has been described in HD and may include abnormalities in circadian-driven metabolism., Objective: Here we investigated metabolite profiles in the transgenic sheep model of HD (OVT73) at presymptomatic ages. Our goal was to understand changes to the metabolome as well as potential metabolite rhythm changes associated with HD., Methods: We used targeted liquid chromatography mass spectrometry (LC-MS) metabolomics to analyze metabolites in plasma samples taken from female HD transgenic and normal (control) sheep aged 5 and 7 years. Samples were taken hourly across a 27-h period. The resulting dataset was investigated by machine learning and chronobiological analysis., Results: The metabolic profiles of HD and control sheep were separable by machine learning at both ages. We found both absolute and rhythmic differences in metabolites in HD compared to control sheep at 5 years of age. An increase in both the number of disturbed metabolites and the magnitude of change of acrophase (the time at which the rhythms peak) was seen in samples from 7-year-old HD compared to control sheep. There were striking similarities between the dysregulated metabolites identified in HD sheep and human patients (notably of phosphatidylcholines, amino acids, urea, and threonine)., Conclusion: This work provides the first integrated analysis of changes in metabolism and circadian rhythmicity of metabolites in a large animal model of presymptomatic HD.
Published: 2023
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27. Application of potassium humate to reduce arsenic bioavailability and toxicity in rice plants (Oryza sativa L.) during its course of germination and seedling growth.

Author: Ray I, Mridha D, Sarkar J, Joardar M, Das A, Chowdhury NR, De A, Acharya K, and Roychowdhury T
Subjects: Antioxidants metabolism, Biological Availability, Carcinogens, Chlorophyll, Fluorescent Dyes, Germination, Plant Roots metabolism, Potassium, Reactive Oxygen Species, Seedlings, Arsenic analysis, Oryza chemistry
Abstract: Arsenic (As), a metalloid is a class I carcinogen and is a major problem in various parts of the world. Food crops are severely affected due to As poisoning and suffer from low germination, yield and disfiguration of morphological and anatomical traits. To attenuate such adverse effects and tone down As uptake by plants, the present study attempts to explore the role of K-humate (KH) in alleviation of As toxicity in rice. KH was administered in the growth media containing 800 ppb As (III) at varying doses to observe the stress alleviating capacity of the amendment. Five treatments were investigated, viz: (a) 800 ppb As (control), (b) 800 ppb As + 25 ppm KH, (c) 800 ppb As + 50 ppm KH, (d) 800 ppb As + 75 ppm KH and (e) 800 ppb As + 100 ppm KH. The results of the amendment administration were noted at 14 days after seeding (DAS). Application of KH significantly improved germination percentage, vigour indices and chlorophyll content by reducing the oxidative stress, antioxidant and antioxidant enzyme activities under As stress. In vivo detection of reactive oxygen species (ROS) using DCF-2DA fluorescent dye and scanning electron microscope (SEM) study of root further depicted that KH application effectively reduced ROS formation and improved root anatomical structure under As stress, respectively. Gradually increasing concentrations of KH was capable of decreasing the bioavailability of As to the rice plants, thus minimizing toxic effect of the metalloid., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier Ltd. All rights reserved.)
Published: 2022
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28. Modeling a sustainable vaccine supply chain for a healthcare system.

Author: Chowdhury NR, Ahmed M, Mahmud P, Paul SK, and Liza SA
Abstract: This study develops a vaccine supply chain (VSC) to ensure sustainable distribution during a global crisis in a developing economy. In this study, a multi-objective mixed-integer programming (MIP) model is formulated to develop the VSC, ensuring the entire network's economic performance. This is achieved by minimizing the overall cost of vaccine distribution and ensuring environmental and social sustainability by minimizing greenhouse gas (GHG) emissions and maximizing job opportunities in the entire network. The shelf-life of vaccines and the uncertainty associated with demand and supply chain (SC) parameters are also considered in this study to ensure the robustness of the model. To solve the model, two recently developed metaheuristics-namely, the multi-objective social engineering optimizer (MOSEO) and multi-objective feasibility enhanced particle swarm optimization (MOFEPSO) methods-are used, and their results are compared. Further, the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) model has been integrated into the optimization model to determine the best solution from a set of non-dominated solutions (NDSs) that prioritize environmental sustainability. The results are analyzed in the context of the Bangladeshi coronavirus disease (COVID-19) vaccine distribution systems. Numerical illustrations reveal that the MOSEO-TOPSIS model performs substantially better in designing the network than the MOFEPSO-TOPSIS model. Furthermore, the solution from MOSEO results in achieving better environmental sustainability than MOFEPSO with the same resources. Results also reflect that the proposed MOSEO-TOPSIS can help policymakers establish a VSC during a global crisis with enhanced economic, environmental, and social sustainability within the healthcare system., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2022 Elsevier Ltd. All rights reserved.)
Published: 2022
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29. Rice grain arsenic and nutritional content during post harvesting to cooking: A review on arsenic bioavailability and bioaccessibility in humans.

Author: Mridha D, Gorain PC, Joardar M, Das A, Majumder S, De A, Chowdhury NR, Lama U, Pal R, and Roychowdhury T
Subjects: Biological Availability, Cooking methods, Edible Grain chemistry, Food Contamination analysis, Humans, Arsenic analysis, Oryza
Abstract: Rice (Oryza sativa L.) is considered as the staple food for 50% of the world's population. Humans are exposed to arsenic (As) through rice consumption, which is a global health issue that requires attention. The present review reflects the scenario of rice grown in As endemic regions of Asia that has a significant portion of inorganic As (iAs) compared to other rice grown areas around the world. Post-harvesting, pre-cooking, and cooking procedures in South and South-East Asian countries employ As-contaminated groundwater. Polishing of brown rice and parboiling, washing and cooking with As-safe water can reduce As concentration and nutrient level in cooked rice. However, in rural parts of South-east Asia, rice is usually cooked using As-contaminated groundwater and consumption of this As enriched rice and water may cause a significant health exposure in humans. Bioaccessibility and bioavailability of As can be determined using in-vitro and in-vivo techniques that can be utilized as a tool to assess As exposure in humans. Arsenic in cooked rice may be reduced by using newly developed cooking procedures such as Kateh cooking, steam percolating, and the parboiled and absorbed (PBA) method. For individuals living in rural regions, using rainwater or treated surface water for drinking and cooking is also an alternative. Although this study examined the processes involved in the post-harvesting, pre-cooking, and cooking stages, there are still significant research gaps in this area that must be addressed in near future., (Copyright © 2022 Elsevier Ltd. All rights reserved.)
Published: 2022
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30. Phase I/II study of the LAG-3 inhibitor ieramilimab (LAG525) ± anti-PD-1 spartalizumab (PDR001) in patients with advanced malignancies.

Author: Schöffski P, Tan DSW, Martín M, Ochoa-de-Olza M, Sarantopoulos J, Carvajal RD, Kyi C, Esaki T, Prawira A, Akerley W, De Braud F, Hui R, Zhang T, Soo RA, Maur M, Weickhardt A, Krauss J, Deschler-Baier B, Lau A, Samant TS, Longmire T, Chowdhury NR, Sabatos-Peyton CA, Patel N, Ramesh R, Hu T, Carion A, Gusenleitner D, Yerramilli-Rao P, Askoxylakis V, Kwak EL, and Hong DS
Subjects: Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal, Humanized pharmacology, Humans, Immune Checkpoint Inhibitors pharmacology, Middle Aged, Young Adult, Antibodies, Monoclonal, Humanized therapeutic use, Immune Checkpoint Inhibitors therapeutic use, Immunotherapy methods, Neoplasms drug therapy
Abstract: Background: Lymphocyte-activation gene 3 (LAG-3) is an inhibitory immunoreceptor that negatively regulates T-cell activation. This paper presents preclinical characterization of the LAG-3 inhibitor, ieramilimab (LAG525), and phase I data for the treatment of patients with advanced/metastatic solid tumors with ieramilimab ±the anti-programmed cell death-1 antibody, spartalizumab., Methods: Eligible patients had advanced/metastatic solid tumors and progressed after, or were unsuitable for, standard-of-care therapy, including checkpoint inhibitors in some cases. Patients received ieramilimab ±spartalizumab across various dose-escalation schedules. The primary objective was to assess the maximum tolerated dose (MTD) or recommended phase II dose (RP2D)., Results: In total, 255 patients were allocated to single-agent ieramilimab (n=134) and combination (n=121) treatment arms. The majority (98%) had received prior antineoplastic therapy (median, 3). Four patients experienced dose-limiting toxicities in each treatment arm across various dosing cohorts. No MTD was reached. The RP2D on a 3-week schedule was declared as 400 mg ieramilimab plus 300 mg spartalizumab and, on a 4-week schedule (once every 4 weeks; Q4W), as 800 mg ieramilimab plus 400 mg spartalizumab; tumor target (LAG-3) suppression with 600 mg ieramilimab Q4W was predicted to be similar to the Q4W, RP2D schedule. Treatment-related adverse events (TRAEs) occurred in 75 (56%) and 84 (69%) patients in the single-agent and combination arms, respectively. Most common TRAEs were fatigue, gastrointestinal, and skin disorders, and were of mild severity; seven patients experienced at least one treatment-related serious adverse event in the single-agent (5%) and combination group (5.8%). Antitumor activity was observed in the combination arm, with 3 (2%) complete responses and 10 (8%) partial responses in a mixed population of tumor types. In the combination arm, eight patients (6.6%) experienced stable disease for 6 months or longer versus six patients (4.5%) in the single-agent arm. Responding patients trended towards having higher levels of immune gene expression, including CD8 and LAG3 , in tumor tissue at baseline., Conclusions: Ieramilimab was well tolerated as monotherapy and in combination with spartalizumab. The toxicity profile of ieramilimab in combination with spartalizumab was comparable to that of spartalizumab alone. Modest antitumor activity was seen with combination treatment., Trial Registration Number: NCT02460224., Competing Interests: Competing interests: PS reports honoraria and consulting/advisory roles for Deciphera, Blueprint Medicines, and Boehringer Ingelheim; consulting/advisory roles for Ellipses Pharma, Transgene, Exelixis, Medscape, Guided Clarity, Ysios Capital, Adaptimmune, Intellisphere, and Advanced Medicine; research funding for CoBioRes NV, Eisai, GI Therapeutics, Novartis, and PharmaMar; and travel expenses for Boehringer Ingelheim, MSD, and Ipsen. DSWT reports honoraria and consulting/advisory roles for Merck, Pfizer, Novartis, Boehringer Ingelheim, Roche, and Takeda; consulting/advisory roles for Bayer, AstraZeneca, Eli Lilly, and GlaxoSmithKline; and research funding for Novartis, AstraZeneca, GlaxoSmithKline, Bayer, Pfizer, and Amgen. MigM reports honoraria and consulting/advisory roles for Roche/Genentech, Eli Lilly, Pfizer, Novartis, and Pierre-Fabre; consulting/advisory roles for AstraZeneca, Taiho Pharmaceuticals, and PharmaMar; research funding for Novartis, Roche/Genentech, and Puma; speaker’s bureau for Eli Lilly/ImClone, Roche/Genentech, and Pierre-Fabre; and other relationship with Roche/Genentech. MOdO reports honoraria for MSD. JS reports consulting/advisory roles for Astellas Pharma, AstraZeneca/MedImmune, Bayer, Eisai, Roche/Genentech, Pfizer, Immunocore, Seagen, Novartis, Sun Pharma, EMD Serono, Amgen, Bristol-Myer Squib, Flugent Therapeutics, Exelixis, Merck, Takeda, and Array BioPharma. RDC reports consulting/advisory roles and research funding for Merck, Aura Biosciences, Castle Biosciences, Immunocore, PureTech, Sorrento Therapeutics, Chimeron Bio, Regenix, InxMed, Pierre Fabre, TriSalus Life Sciences, Iovance Biotherapeutics, Oncosec, Regeneron, Genzyme, Amgen, Astellas Pharma, AstraZeneca, Bristol-Myer Squib/Medarex, Corvus Pharmaceuticals, Ideya, Mirati Therapeutics, Novartis, Pfizer, Plexxikon, and Roche/Genentech; research funding for Bayer, Bellicum Pharmaceuticals, Eli Lilly, Immunocore, Incyte, Macrogenics, Merck, Mirati Therapeutics, Array BioPharma, IDEAYA Biosciences, and Regeneron; and speaker’s bureau for Bristol-Myer Squib/Medarex.CK reports research funding for Bristol-Myers Squibb, Merus, and Gritstone Oncology. TE reports research funding for Novartis, Astellas Pharma, Sumitomo Group, Eli Lilly, Amgen, Quintiles, Daiichi Sankyo, Bayer, Eisai, IQVIA, MSD, Ono Pharmaceutical, Parexel, Nihonkayaku, and Taiho Pharmaceuticals. AP is an employee of, and reports honoraria for, Novotech; and reports research funding for Roche/Genentech, Bristol-Myers Squibb, Hutchison MediPharma, Merck, Bayer, Macrogenics, Pfizer, Akeso Biopharma, BeiGene, CStone Pharmaceuticals, Five Prime Therapeutics, CBT Pharmaceuticals, Arcus Biosciences, Corvus Pharmaceuticals, Eli Lilly, Henlius, QBiotics, Virogin, GlaxoSmithKline, Theradex, ENB Therapeutics, InxMed, Seattle Genetics, Janssen, Starpharma, and QBiotics. FDB reports honoraria and consulting/advisory roles for Roche, Pfizer, Bristol-Myers Squibb, Merk, MSD, Servier, and Sanofi; consulting/advisory roles for Incyte, Teofarma, EMD Serono, Nerviano Medical Sciences, Sanofi, and Novartis; and research funding for Novartis, Roche, Merck Serono, Pfizer, Servier, Philogen, Loxo Oncology, Tesaro, Nerviano Medical Sciences, and Kymab. RH reports honoraria and consulting/advisory roles for AstraZenca, Bristol-Myers Squibb, Eisai, Eli Lilly, Merck, MSD, Novartis, Oncosec, Pfizer, Roche and Seagen; research funding from AstraZeneca, Eli Lilly, MSD, Roche, Seagen, OncoSec, and Novartis; and travel expenses from Novartis. TZ reports immediate family connections to Capio BioSciences and Archimmume Therapeutics; these relatives also own stock at these companies and at Nanarobotics. TZ reports honoraria for Exelixis, Roche/Genentech, MJH Life Sciences, and Pacific Genuity; consulting/advisory roles for Janssen, Roche/Genentech, Sanofi, Exelixis, AstraZeneca, Pfizer, Bristol-Myers Squibb, Foundation Medicine, Pharmacyclics, Amgen, Merck, Seattle Genetics, Dendreon, and Calithera Biosciences; speaker’s Bureau for Exelixis, Roche/Genentech, Genomic Health, and Sanofi/Aventis; research funding for Astellas Pharma, Janssen, Acerta Pharma, Pfizer, Merrimack, Stem CentRx, Novartis, OmniSeq, Personal Genome Diagnostics, Regeneron, Merck, and Mirati Therapeutics; patents, royalties and other intellectual property for circulating tumor cell novel capture by c-MET technology and prochelators as Targeted Prodrugs for Prostate Cancer; and travel expenses for Acerta Pharma, Genomic Health, and AstraZeneca. RAS reports honoraria and consulting/advisory roles for AstraZeneca, Boehringer Ingelheim, Bristol-Myers Squibb, Eli Lilly, Novartis, Pfizer, Roche/Genentech, Takeda, Yuhan, Amgen, Bayer, and Merck; consulting/advisory roles for Taiho Pharmaceutical, Yuhan, Takeda, Amgen, and Merck; and research funding for AstraZeneca and Boehringer Ingelheim. AW reports honoraria for Eisai and Merck; consulting/advisory roles for Merck and Bristol-Myers Squibb; speaker’s bureau for Astellas Pharma and Merck; and travel expenses for Astellas Pharma, Ipsen, and Merck. JK is employed by, and reports receiving leadership fees, patents, royalties or other intellectual property for, Heidelberg ImmunoTherapeutics; and reports research funding for Vaccibody. AL, TS, VA, and EK are employees of Novartis. DG is an employee of Novartis and Mercy BioAnalytics. TS has a spouse who is employed by Teva Pharmaceuticals. NRC is an employee of, and owns stock in, Novartis. CASP was an employee of Novartis and owns stock in, holds patents, royalties, or other intellectual property in Novartis, and is also employed by, and has stock options in, Larkspur Biosciences. RR is an employee of, and holds stock in, Novartis and Takeda. TH is an employee of ViiV Healthcare, owns stock in ViiV Healthcare and Novartis, and holds patents, royalties, or other intellectual property in Novartis. PYR is an employee of, and holds stock in, Novartis. DSH owns stock in MolecularMatch, Presagia, and OncoResponse; reports consulting/advisory roles and research funding for Bayer, Guidepoint Global, Alpha Insights, Axiom Biotechnologies, Merrimack, Medscape, Numab, Pfizer, Seattle Genetics, Takeda, Trieza Therapeutics, WebMD, Infinity Pharmaceuticals, Amgen, Adaptimmune, Boxer Capital, ECOR1, Tavistock, Baxter, COG, Genentech, Group H, Janssen, Acuta, HCW Precision, Infinity, Prime Oncology, and ST Cube; research funding for Daiichi Sankyo, AbbVie, Kite Pharma, MedImmune, Molecular Templates, NCI-CTEP Fate Therapeutics, Novartis, Turning Point Therapeutics, Verstatem, Kyowa, Loxo Oncology, Merck, Eisai, Genmab, Ignyta, Mirati Therapeutics, miRNA, Mologen, Takeda, AstraZeneca, Navier, VM Oncology, Erasca, Inc, Eli Lilly, Bristol-Myers Squibb, EMD Serono, GlaxoSmithKline, Millenium, and Adlai Nortye; and travel expenses for Genmab, SITC, Bayer Schering Pharma, miRNA, Loxo Oncology, Amgen, AstraZeneca, Celgene, Eli Lilly, Genentech, GlaxoSmithKline, Janssen, Pfizer, Philips, and Takeda. MicM, WA, BDB, TL, NP, and AC report no conflicts of interest., (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.)
Published: 2022
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31. Effect of sulfate application on inhibition of arsenic bioaccumulation in rice (Oryza sativa L.) with consequent health risk assessment of cooked rice arsenic on human: A pot to plate study.

Author: Mridha D, Ray I, Sarkar J, De A, Joardar M, Das A, Chowdhury NR, Acharya K, and Roychowdhury T
Subjects: Bioaccumulation, Child, Cooking, Food Contamination analysis, Humans, Risk Assessment, Sulfates, Arsenic analysis, Oryza
Abstract: Arsenic (As) in rice is posing a serious threat worldwide and consumption of As contaminated rice by human is causing health risks. A pot experiment with different levels of sulfate dosage (0, 20, 40, 60 and 80 mg/kg) was set up in this study to explore the influence of sulfate fertilizer on rice plant growth, yield, and As accumulation in rice grain. Apart from As bioaccumulation in rice grains, the As fraction of cooked rice was quantified, and the health risks associated with cooked rice consumption were also investigated. The sulfate application significantly (p ≤ 0.05) enhanced the chlorophyll, tiller number, grains per panicle, grain and biomass yield under As stressed condition. The sulfate application also reduced the oxidative stress and antioxidant activity in rice plants. Sulfate fertigation improved the accumulation of total sulfur (S) and reduced the uptake and translocation of As in rice plants. Arsenic concentration in rice grain was reduced by 50.1% in S80 treatment (80 mg of sulfate/kg of soil) as compared to S0 set. The reduction percentage of As in cooked parboiled and sunned rice with correspond to raw rice ranged from 55.9 to 74% and 40.3-60.7%, respectively. However, the sulfate application and cooking of parboiled rice reduced the potential non-cancer and cancer risk as compared to sunned rice. The S80 treatment and cooking of parboiled rice reduce the As exposure for both children and adults by 51% as compared to cooked sunned rice under S80 treatment and this trend was similar for all treatments. Therefore, sulfate application in soil can be recommended to produce safer rice grains and subsequent cooking of parboiled rice grain with low-As contaminated water need to be done to avoid any potential health risk in As endemic areas., (Copyright © 2021 Elsevier Ltd. All rights reserved.)
Published: 2022
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32. Phase I study of single agent NIZ985, a recombinant heterodimeric IL-15 agonist, in adult patients with metastatic or unresectable solid tumors.

Author: Conlon K, Watson DC, Waldmann TA, Valentin A, Bergamaschi C, Felber BK, Peer CJ, Figg WD, Potter EL, Roederer M, McNeel DG, Thompson JA, Gupta S, Leidner R, Wang-Gillam A, Parikh NS, Long D, Kurtulus S, Ho Lee L, Chowdhury NR, Bender F, and Pavlakis GN
Subjects: Adult, Aged, Female, Humans, Immunotherapy, Male, Middle Aged, Neoplasm Metastasis, Protein Multimerization, Recombinant Proteins administration & dosage, Interleukin-15 administration & dosage, Interleukin-15 agonists, Neoplasms drug therapy, Receptors, Interleukin-15 administration & dosage
Abstract: Background: NIZ985 is a recombinant heterodimer of physiologically active interleukin (IL-)15 and IL-15 receptor alpha. In preclinical models, NIZ985 promotes cytotoxic lymphocyte proliferation, killing function, and organ/tumor infiltration, with resultant anticancer effects. In this first-in-human study, we assessed the safety, pharmacokinetics, and immune effects of NIZ985 in patients with metastatic or unresectable solid tumors., Methods: Single agent NIZ985 dose escalation data are reported from a phase I dose escalation/expansion study of NIZ985 as monotherapy. Adult patients (N=14) received 0.25, 0.5, 1, 2 or 4 µg/kg subcutaneous NIZ985 three times weekly (TIW) for the first 2 weeks of each 28-day cycle, in an accelerated 3+3 dose escalation trial design. IL-15 and endogenous cytokines were monitored by ELISA and multiplexed electrochemiluminescent assays. Multiparameter flow cytometry assessed the frequency, phenotype and proliferation of peripheral blood mononuclear cells. Preliminary antitumor activity was assessed by overall response rate (Response Evaluation Criteria in Solid Tumors V.1.1)., Results: As of March 2, 2020, median treatment duration was 7.5 weeks (range 1.1-77.1). Thirteen patients had discontinued and one (uveal melanoma) remains on treatment with stable disease. Best clinical response was stable disease (3 of 14 patients; 21%). The most frequent adverse events (AEs) were circular erythematous injection site reactions (100%), chills (71%), fatigue (57%), and fever (50%). Treatment-related grade 3/4 AEs occurred in six participants (43%); treatment-related serious AEs (SAEs) in three (21%). The per-protocol maximum tolerated dose was not reached. Pharmacokinetic accumulation of serum IL-15 in the first week was followed by significantly lower levels in week 2, likely due to more rapid cytokine consumption by an expanding lymphocyte pool. NIZ985 treatment was associated with increases in several cytokines, including interferon (IFN)-γ, IL-18, C-X-C motif chemokine ligand 10, and tumor necrosis factor-β, plus significant induction of cytotoxic lymphocyte proliferation (including natural killer and CD8 + T cells), increased CD16 + monocytes, and increased CD163 + macrophages at injection sites., Conclusions: Subcutaneous NIZ985 TIW was generally well tolerated in patients with advanced cancer and produced immune activation paralleling preclinical observations, with induction of IFN-γ and proliferation of cytotoxic lymphocytes. Due to delayed SAEs at the two highest dose levels, administration is being changed to once-weekly in a revised protocol, as monotherapy and combined with checkpoint inhibitor spartalizumab. These alterations are expected to maximize the potential of NIZ985 as a novel immunotherapy., Trial Registration Number: NCT02452268., Competing Interests: Competing interests: AV, CB, BKF, and GNP report inventorship in issued patents of relevance to this work (licensed to Novartis; managed by the National Cancer Institute) and other support by Novartis during the conduct of this study. DGM and TAW report other support from Novartis during the conduct of the study. JT reports grants from Alpine Biosciences, other support from Novartis during the conduct of the study, other support from Pfizer, Five Prime, Merck, Trillium, Incyte and Xencor outside of the current work, and personal fees from Regeneron, Aveo, Neoleukin, Seattle Genetics, BJ Biosciences, and Calithera outside of the current work. SG reports other support from Novartis during the conduct of the study, other support from Bristol Myers Squibb, Rexahn, Incyte, LSK, Five Prime, Mirati, QED, Debiopharm, Merck, Pfizer, AstraZeneca, Medimmune, Clovis, and Seattle Genetics outside of the current work, and ownership of stock in Salerius Pharmaceuticals by spouse. RL reports grants and personal fees from Bristol Myers Squibb, personal fees from Merck, Oncolys, and Sanofi, and non-financial support from Clinigen outside of the current work. NSP, DL, SK, LHL, NRC and FB are, or were at the time of the work described, employees of Novartis Pharmaceuticals. KC, DCW, CJP, WF, ELP, MR and AW-G report nothing to disclose., (© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.)
Published: 2021
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33. Arsenic toxicity in livestock growing in arsenic endemic and control sites of West Bengal: risk for human and environment.

Author: Das A, Joardar M, Chowdhury NR, De A, Mridha D, and Roychowdhury T
Subjects: Animals, Arsenic analysis, Arsenic toxicity, Cattle, Female, Humans, India epidemiology, Male, Milk chemistry, Water Pollutants, Chemical analysis, Water Pollutants, Chemical toxicity, Arsenic Poisoning, Livestock
Abstract: The present study aims to estimate geochemical arsenic toxicity in the domestic livestock and possible risk for human and environment caused by them. Daily dietary arsenic intake of an exposed adult cow or bull is nearly 4.56 times higher than control populace and about 3.65 times higher than exposed goats. Arsenic toxicity is well exhibited in all the biomarkers through different statistical interpretations. Arsenic bioconcentration is faster through water compared to paddy straw and mostly manifested in faeces and tail hair in cattle. Cow dung and tail hair are the most pronounced pathways of arsenic biotransformation into environment. A considerable amount of arsenic has been observed in animal proteins such as cow milk, boiled egg yolk, albumen, liver and meat from the exposed livestock. Cow milk arsenic is mostly accumulated in casein (83%) due to the presence of phosphoserine units. SAMOE-risk thermometer, calculated for the most regularly consumed foodstuffs in the area, shows the human health risk in a distinct order: drinking water > rice grain > cow milk > chicken > egg > mutton ranging from class 5 to 1. USEPA health risk assessment model reveals more risk in adults than in children, subsisting severe cancer risk from the foodstuffs where the edible animal proteins cannot be ignored. Therefore, the domestic livestock should be urgently treated with surface water, while provision of both arsenic-free drinking water and nutritional supplements is mandatory for the affected human population to overcome the severe arsenic crisis situation., (© 2021. The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature.)
Published: 2021
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34. Health effect and risk assessment of the populations exposed to different arsenic levels in drinking water and foodstuffs from four villages in arsenic endemic Gaighata block, West Bengal, India.

Author: Joardar M, Das A, Chowdhury NR, Mridha D, De A, Majumdar KK, and Roychowdhury T
Subjects: Arsenic analysis, Arsenic toxicity, Environmental Exposure analysis, Humans, India epidemiology, Risk Assessment, Water Pollutants, Chemical analysis, Water Pollutants, Chemical toxicity, Drinking Water analysis
Abstract: Health exposure and perception of risk assessment have been evaluated on the populations exposed to different arsenic levels in drinking water (615, 301, 48, 20 µg/l), rice grain (792, 487, 588, 569 µg/kg) and vegetables (283, 187, 238, 300 µg/kg) from four villages in arsenic endemic Gaighata block, West Bengal. Dietary arsenic intake rates for the studied populations from extremely highly, highly, moderately, and mild arsenic-exposed areas were 56.03, 28.73, 11.30, and 9.13 μg/kg bw/day, respectively. Acute and chronic effects of arsenic toxicity were observed in ascending order from mild to extremely highly exposed populations. Statistical interpretation using 'ANOVA' proves a significant relationship between drinking water and biomarkers, whereas "two-tailed paired t test" justifies that the consumption of arsenic-contaminated dietary intakes is the considerable pathway of health risk exposure. According to the risk thermometer (SAMOE), drinking water belongs to risk class 5 (extremely highly and highly exposed area) and 4 (moderately and mild exposed area) category, whereas rice grain and vegetables belong to risk class 5 and 4, respectively, for all the differently exposed populations. The carcinogenic (ILCR) and non-carcinogenic risks (HQ) through dietary intakes for adults were much higher than the recommended threshold level, compared to the children. Supplementation of arsenic-safe drinking water and nutritional food is strictly recommended to overcome the severe arsenic crisis., (© 2021. The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature.)
Published: 2021
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35. Rice seed (IR64) priming with potassium humate for improvement of seed germination, seedling growth and antioxidant defense system under arsenic stress.

Author: Mridha D, Paul I, De A, Ray I, Das A, Joardar M, Chowdhury NR, Bhadoria PBS, and Roychowdhury T
Subjects: Antioxidants pharmacology, Arsenic pharmacology, Germination drug effects, Oryza drug effects, Potassium pharmacology, Seedlings drug effects, Seeds drug effects, Arsenic toxicity, Oryza physiology
Abstract: The intolerable levels of arsenic (As) in groundwater and its application in rice cultivation are continuously affecting the rice production in Ganga-Meghna-Brahmaputra (GMB) plain. The reduced germination and plant growth rates under excessive As stress ultimately lead to lower yield. To mitigate this concerning issue, the present study was carried out to evaluate the potential of K-humate priming on seed germination and plant growth under As stress. Seeds were primed with 100 mg/l K-humate for 12 h prior to germination. The germination percentages in unprimed seeds were 65 ± 5.0% and 58.3 ± 7.6% under stress level of 50 μM AsV and 50 μM AsIII, respectively. However, germination percentage in K-humate primed seeds were 75 ± 5.0% and 68.3 ± 2.9% under AsV and AsIII stress, respectively. The vigour index I (VG I) and vigour index II (VG II) recorded on 12 DAS (days after seeding) were also increased by 1.47 and 1.51 fold, respectively with K-humate supplementation under As stress. Detrimental effects of AsIII on seed germination, seedling growth and other physiological parameters were more suppressive than AsV. Application of K-humate not only improved seed germination, seedling growth and nutrient uptake but also decreased the oxidative stress markers and antioxidant activities by minimizing As uptake and translocation in the seedlings., (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
Published: 2021
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36. Application of Pomegranate by-Products in Muscle Foods: Oxidative Indices, Colour Stability, Shelf Life and Health Benefits.

Author: Das AK, Nanda PK, Chowdhury NR, Dandapat P, Gagaoua M, Chauhan P, Pateiro M, and Lorenzo JM
Subjects: Animals, Humans, Antioxidants chemistry, Dietary Supplements, Food Preservatives chemistry, Fruit chemistry, Meat, Plant Extracts chemistry, Pomegranate chemistry
Abstract: In recent years, considerable importance is given to the use of agrifood wastes as they contain several groups of substances that are useful for development of functional foods. As muscle foods are prone to lipid and protein oxidation and perishable in nature, the industry is in constant search of synthetic free additives that help in retarding the oxidation process, leading to the development of healthier and shelf stable products. The by-products or residues of pomegranate fruit (seeds, pomace, and peel) are reported to contain bioactive compounds, including phenolic and polyphenolic compounds, dietary fibre, complex polysaccharides, minerals, vitamins, etc. Such compounds extracted from the by-products of pomegranate can be used as functional ingredients or food additives to harness the antioxidant, antimicrobial potential, or as substitutes for fat, and protein in various muscle food products. Besides, these natural additives are reported to improve the quality, safety, and extend the shelf life of different types of food products, including meat and fish. Although studies on application of pomegranate by-products on various foods are available, their effect on the physicochemical, oxidative changes, microbial, colour stabilizing, sensory acceptability, and shelf life of muscle foods are not comprehensively discussed previously. In this review, we vividly discuss these issues, and highlight the benefits of pomegranate by-products and their phenolic composition on human health.
Published: 2021
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37. Monsoonal paddy cultivation with phase-wise arsenic distribution in exposed and control sites of West Bengal, alongside its assimilation in rice grain.

Author: Chowdhury NR, Das A, Mukherjee M, Swain S, Joardar M, De A, Mridha D, and Roychowdhury T
Subjects: Soil, Arsenic analysis, Groundwater, Oryza, Soil Pollutants analysis
Abstract: The present study mainly deals with monsoonal paddy farming with respect to its phase-wise arsenic (As) accumulation and distribution throughout cultivation in As exposed sites and control areas of West Bengal for two consecutive years, 2017 and 2018. Arsenic uptake in paddy depends on the watering pattern with the help of groundwater (Madhusudhankati: 171 μg/l, Teghoria: 493 μg/l in Gaighata and Pingla: 10 μg/l in Medinipur), soil As phase-wise movement with its enrichment pattern and the variation of rainfall. Arsenic mobility is the highest in root and decreases with height of a plant. However, the synergistic effect of groundwater and rainwater makes a diffused approach to the nature of As flow in plants, because rainwater has a pivotal role in diluting the As content available for translocation. Reproductive phase accumulates maximum As compared to vegetative and ripening phases. Sequential extraction and SEM studies re-confirm no possibility of iron (Fe) plaque formation in root soils which sequestered As. Finally, we conclude that monsoonal cultivation provides least As enriched grain (exposed area: 350 μg/kg, control area: 224 μg/kg) irrespective of the variety of cultivar and area of cultivation, which amounts to one-third of pre-monsoonal grain (1120 μg/kg) and so, it is much safer for consumption with respect to As and micro-nutrient status., (Copyright © 2020 Elsevier B.V. All rights reserved.)
Published: 2020
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38. Comparison of the Biocidal Efficacy of Sodium Dichloroisocyanurate and Calcium Hydroxide as Intracanal Medicaments over a 7-Day Contact Time: An Ex Vivo Study.

Author: Chan W, Chowdhury NR, Sharma G, Zilm P, and Rossi-Fedele G
Subjects: Dental Pulp Cavity, Enterococcus faecalis, Humans, Triazines, Calcium Hydroxide, Root Canal Irrigants
Abstract: Introduction: The use of medicaments has been recommended for the treatment of root canal infection. This study evaluated the antimicrobial effect of a well-known biocidal agent, sodium dichloroisocyanurate (NaDCC), by comparing it with calcium hydroxide [Ca(OH) 2 ] using an engineered 3-species biofilm root canal model., Methods: Thirty-eight human single-rooted teeth were decoronated and chemomechanically prepared before inoculation using Enterococcus faecalis, Actinomyces viscosus, and Streptococcus mutans using a flow cell model for 4 weeks for biofilm formation. The samples were randomly divided into 3 groups: NaDCC (n = 12), Ca(OH) 2 (n = 12), and positive control (no medicament, n = 14). The medicaments were placed using a Lentulo spiral. After a contact time of 7 days, the roots were crushed and plated on selective media. Bacterial identities were confirmed with the use of selective media. Colony-forming units were calculated (CFU/ml). Descriptive statistics (mean and standard deviations) were calculated., Results: Seven-day dressing with NaDCC or Ca(OH) 2 presented with no growth. For the positive control, the mean colony-forming units were 2.97E4 ± 3.42E4 (CFU/ml). All previously inoculated strains were recovered in the control group., Conclusions: NaDCC and Ca(OH) 2 when used as intracanal medicaments were able to eradicate an engineered 3-species biofilm in single-rooted teeth in an ex vivo model. NaDCC deserves further investigation as an intracanal medicament., (Copyright © 2020 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.)
Published: 2020
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39. Flow of arsenic between rice grain and water: Its interaction, accumulation and distribution in different fractions of cooked rice.

Author: Chowdhury NR, Das A, Joardar M, De A, Mridha D, Das R, Rahman MM, and Roychowdhury T
Subjects: Cooking, Food Contamination analysis, Humans, Water, Arsenic analysis, Oryza
Abstract: Arsenic (As) contaminated water is a major threat to human health when used for drinking, cooking and irrigational purposes. Rice being consumed by 50% of the world's population, supplies considerable amount of As to the human body. Our study provides a detailed understanding of As distribution in each fraction of rice while cooking (viz. uncooked rice, cooking water, cooked rice and gruel/total discarded water), ultimately leading to a better explanation of As movement between rice grain and water. A significant decrease of As was observed in cooked rice (34-89% and 23-84% for sunned and parboiled rice respectively) when cooked with low-As containing water, <3 μg/l and moderate As-contaminated water, 36-58 μg/l (3-50% and 12-61% for sunned and parboiled rice respectively) with increasing selenium (Se) concentration. Movement of As from water to rice grain has been inferred with increasing water As (84-105 μg/l), which results in a significant increase of As in cooked rice (24-337% and 114% for sunned and parboiled rice, respectively) with decreasing Se concentration. Arsenic speciation study emphasizes the fact of similar reduction percentage of As (III), As (V) and total As in wet cooked rice when cooked with low-As containing water. The SAMOE value in 'risk thermometer' supports the higher risk of suffering from wet cooked rice (class 4) with increasing cooking water As concentration (class 3 to class 5)., Competing Interests: Declaration of competing interest The authors have no conflict of interest., (Copyright © 2020. Published by Elsevier B.V.)
Published: 2020
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40. Genomic Profiling of Metastatic Uveal Melanoma and Clinical Results of a Phase I Study of the Protein Kinase C Inhibitor AEB071.

Author: Piperno-Neumann S, Larkin J, Carvajal RD, Luke JJ, Schwartz GK, Hodi FS, Sablin MP, Shoushtari AN, Szpakowski S, Chowdhury NR, Brannon AR, Ramkumar T, de Koning L, Derti A, Emery C, Yerramilli-Rao P, and Kapiteijn E
Subjects: Adolescent, Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Gene Expression Profiling, Humans, Male, Maximum Tolerated Dose, Melanoma genetics, Melanoma pathology, Middle Aged, Neoplasm Metastasis, Prognosis, Pyrroles pharmacokinetics, Quinazolines pharmacokinetics, Tissue Distribution, Uveal Neoplasms genetics, Uveal Neoplasms pathology, Young Adult, Biomarkers, Tumor genetics, Gene Expression Regulation, Neoplastic, Melanoma drug therapy, Protein Kinase C antagonists & inhibitors, Pyrroles pharmacology, Quinazolines pharmacology, Uveal Neoplasms drug therapy
Abstract: Up to 50% of patients with uveal melanoma (UM) develop metastatic disease, for which there is no effective systemic treatment. This study aimed to evaluate the safety and efficacy of the orally available protein kinase C inhibitor, AEB071, in patients with metastatic UM, and to perform genomic profiling of metastatic tumor samples, with the aim to propose combination therapies. Patients with metastatic UM ( n = 153) were treated with AEB071 in a phase I, single-arm study. Patients received total daily doses of AEB071 ranging from 450 to 1,400 mg. First-cycle dose-limiting toxicities were observed in 13 patients (13%). These were most commonly gastrointestinal system toxicities and were dose related, occurring at doses ≥700 mg/day. Preliminary clinical activity was observed, with 3% of patients achieving a partial response and 50% with stable disease (median duration 15 weeks). High-depth, targeted next-generation DNA sequencing was performed on 89 metastatic tumor biopsy samples. Mutations previously identified in UM were observed, including mutations in GNAQ, GNA11, BAP1, SF3B1, PLCB4 , and amplification of chromosome arm 8q. GNAQ / GNA11 mutations were observed at a similar frequency (93%) as previously reported, confirming a therapeutic window for inhibition of the downstream effector PKC in metastatic UM.In conclusion, the protein kinase C inhibitor AEB071 was well tolerated, and modest clinical activity was observed in metastatic UM. The genomic findings were consistent with previous reports in primary UM. Together, our data allow envisaging combination therapies of protein kinase C inhibitors with other compounds in metastatic UM., (©2020 American Association for Cancer Research.)
Published: 2020
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41. Arsenic contamination in Kolkata metropolitan city: perspective of transportation of agricultural products from arsenic-endemic areas.

Author: Biswas A, Swain S, Chowdhury NR, Joardar M, Das A, Mukherjee M, and Roychowdhury T
Subjects: Adult, Agriculture, Arsenic chemistry, Arsenicals chemistry, Child, Crops, Agricultural, Drinking Water analysis, Edible Grain chemistry, Groundwater, Humans, Oryza, Soil, Vegetables, Water Pollutants, Chemical analysis, Arsenic analysis, Arsenicals analysis, Food Contamination analysis, Soil Pollutants analysis
Abstract: Arsenic exposure route for humans is through the drinking of contaminated water and intake of arsenic-contaminated foods, particularly in arsenic-exposed areas of Bengal delta. Transport of the arsenic-contaminated crops and vegetables grown using arsenic-contaminated groundwater and soil in arsenic-exposed areas to the uncontaminated sites and consequent dietary intakes leads to great threats for the population residing in non-endemic areas with respect to consumption of arsenic through drinking water. We have studied the food materials collected from 30 families and their dietary habits, apparently who consume arsenic-free drinking water as well as 9 well-known markets of Kolkata city. The total and inorganic arsenic intake has been estimated from the collected foodstuffs from the market basket survey (n = 93) and household survey (n = 139), respectively for human risk analysis. About 100% of the collected samples contained detectable amount of arsenic (range 24-324 μg/kg), since the origin of the food materials was somewhere from arsenic-endemic areas. The daily consumption of inorganic arsenic (iAs) from rice grain and vegetables for adult and children is 76 μg and 41.4 μg, respectively. Inorganic arsenic (mainly arsenite and arsenate) contributes approximately 88% of the total content of arsenic in vegetable. In most of the cases, insufficient nutrient intake by the studied population may lead to arsenic toxicity in the long run. An independent cancer risk assessment study on the same population indicates that the main risk of cancer might appear through the intake of arsenic-contaminated rice grain and cereals.
Published: 2019
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42. Chronic sleep restriction in the rotenone Parkinson's disease model in rats reveals peripheral early-phase biomarkers.

Author: Fagotti J, Targa ADS, Rodrigues LS, Noseda ACD, Dorieux FWC, Scarante FF, Ilkiw JL, Louzada FM, Chowdhury NR, van der Veen DR, Middleton B, Pennings JLA, Swann JR, Skene DJ, and Lima MMS
Subjects: Amino Acids, Branched-Chain blood, Animals, Area Under Curve, Biomarkers blood, Chromatography, High Pressure Liquid, Chronic Disease, Discriminant Analysis, Disease Models, Animal, Least-Squares Analysis, Male, Mass Spectrometry, Metabolome drug effects, Parkinson Disease etiology, ROC Curve, Rats, Rats, Wistar, Rotenone toxicity, Sleep Wake Disorders metabolism, Biomarkers metabolism, Parkinson Disease pathology, Sleep Wake Disorders diagnosis
Abstract: Parkinson's disease (PD) is a chronic disorder that presents a range of premotor signs, such as sleep disturbances and cognitive decline, which are key non-motor features of the disease. Increasing evidence of a possible association between sleep disruption and the neurodegenerative process suggests that sleep impairment could produce a detectable metabolic signature on the disease. In order to integrate neurocognitive and metabolic parameters, we performed untargeted and targeted metabolic profiling of the rotenone PD model in a chronic sleep restriction (SR) (6 h/day for 21 days) condition. We found that SR combined with PD altered several behavioural (reversal of locomotor activity impairment; cognitive impairment; delay of rest-activity rhythm) and metabolic parameters (branched-chain amino acids, tryptophan pathway, phenylalanine, and lipoproteins, pointing to mitochondrial impairment). If combined, our results bring a plethora of parameters that represents reliable early-phase PD biomarkers which can easily be measured and could be translated to human studies.
Published: 2019
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43. Arsenic accumulation in paddy plants at different phases of pre-monsoon cultivation.

Author: Chowdhury NR, Das R, Joardar M, Ghosh S, Bhowmick S, and Roychowdhury T
Subjects: Environmental Monitoring methods, Humans, Arsenic analysis, Crops, Agricultural, Oryza physiology, Seasons, Soil Pollutants analysis, Water Pollutants, Chemical analysis
Abstract: Geogenic arsenic (As) contamination in Bengal Delta Plain is a growing environmental and research concern. Cultivation of staple crops like paddy on these contaminated fields is one of the major routes for human dietary exposure. The present study investigates changes of arsenic concentrations in paddy plant parts, root soil and surface soil throughout the various phases of pre-monsoon (boro) cultivation. Arsenic uptake property of paddy plants collected from 10 fields was found to be dependent on the variety of paddy plant (like Minikit, Jaya) rather than arsenic levels in groundwater (0.074-0.301 mg/l) or soil (25.3-60 mg/kg). Arsenic is translocated from root to aerial parts in descending order. Leaf, stem, root, root soil and surface soil showed a similar trend in their change of arsenic concentration throughout the cultivation period. Arsenic concentration was highest in vegetative phase; sharply declined in reproductive phase; followed by moderate increase in ripening phase. The young root tissues in vegetative (primary) phase could uptake arsenic at a much faster rate than the older tissues in later phases. With the growth of the plant, higher concentrations of iron in root soil in the reproductive phase confirmed the formation of iron plaques on the surface of the root, which sequester arsenic and prevented its uptake by plants. Finally, co-precipitation of arsenic with iron released from crystallized iron plaques results in loosening of the iron plaques from root surface. Thus, soil arsenic concentration increases in the final phase of cultivation which in turn contributes to increased concentration in plant parts., (Copyright © 2018 Elsevier Ltd. All rights reserved.)
Published: 2018
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44. Separation of circadian- and behavior-driven metabolite rhythms in humans provides a window on peripheral oscillators and metabolism.

Author: Skene DJ, Skornyakov E, Chowdhury NR, Gajula RP, Middleton B, Satterfield BC, Porter KI, Van Dongen HPA, and Gaddameedhi S
Subjects: Adult, Female, Humans, Male, Biological Clocks physiology, Circadian Rhythm physiology, Fasting blood, Gene Expression Regulation physiology, Hydrocortisone blood, Melatonin blood, Period Circadian Proteins biosynthesis
Abstract: Misalignment between internal circadian rhythmicity and externally imposed behavioral schedules, such as occurs in shift workers, has been implicated in elevated risk of metabolic disorders. To determine underlying mechanisms, it is essential to assess whether and how peripheral clocks are disturbed during shift work and to what extent this is linked to the central suprachiasmatic nuclei (SCN) pacemaker and/or misaligned behavioral time cues. Investigating rhythms in circulating metabolites as biomarkers of peripheral clock disturbances may offer new insights. We evaluated the impact of misaligned sleep/wake and feeding/fasting cycles on circulating metabolites using a targeted metabolomics approach. Sequential plasma samples obtained during a 24-h constant routine that followed a 3-d simulated night-shift schedule, compared with a simulated day-shift schedule, were analyzed for 132 circulating metabolites. Nearly half of these metabolites showed a 24-h rhythmicity under constant routine following either or both simulated shift schedules. However, while traditional markers of the circadian clock in the SCN-melatonin, cortisol, and PER3 expression-maintained a stable phase alignment after both schedules, only a few metabolites did the same. Many showed reversed rhythms, lost their rhythms, or showed rhythmicity only under constant routine following the night-shift schedule. Here, 95% of the metabolites with a 24-h rhythmicity showed rhythms that were driven by behavioral time cues externally imposed during the preceding simulated shift schedule rather than being driven by the central SCN circadian clock. Characterization of these metabolite rhythms will provide insight into the underlying mechanisms linking shift work and metabolic disorders., Competing Interests: The authors declare no conflict of interest., (Copyright © 2018 the Author(s). Published by PNAS.)
Published: 2018
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45. The cosmic ray shadow of the Moon observed with the ANTARES neutrino telescope.

Author: Albert A, André M, Anghinolfi M, Anton G, Ardid M, Aubert JJ, Aublin J, Avgitas T, Baret B, Barrios-Martít J, Basa S, Belhorma B, Bertin V, Biagi S, Bormuth R, Boumaaza J, Bourret S, Bouwhuis MC, Brânzaş H, Bruijn R, Brunner J, Busto J, Capone A, Caramete L, Carr J, Celli S, Chabab M, Moursli RCE, Chiarusi T, Circella M, Coelho JAB, Coleiro A, Colomer M, Coniglione R, Costantini H, Coyle P, Creusot A, Díaz AF, Deschamps A, Distefano C, Palma ID, Domi A, Donzaud C, Dornic D, Drouhin D, Eberl T, Bojaddaini IE, Khayati NE, Elsässer D, Enzenhöfer A, Ettahiri A, Fassi F, Felis I, Fermani P, Ferrara G, Fusco LA, Gay P, Glotin H, Grégoire T, Ruiz RG, Graf K, Hallmann S, van Haren H, Heijboer AJ, Hello Y, Hernández-Rey JJ, Hößl J, Hofestädt J, Illuminati G, de Jong M, Jongen M, Kadler M, Kalekin O, Katz U, Khan-Chowdhury NR, Kouchner A, Kreter M, Kreykenbohm I, Kulikovskiy V, Lachaud C, Lahmann R, Lefèvre D, Leonora E, Levi G, Lotze M, Loucatos S, Marcelin M, Margiotta A, Marinelli A, Martínez-Mora JA, Mele R, Melis K, Migliozzi P, Moussa A, Navas S, Nezri E, Nuñez A, Organokov M, Păvălaş GE, Pellegrino C, Piattelli P, Popa V, Pradier T, Quinn L, Racca C, Randazzo N, Riccobene G, Sánchez-Losa A, Saldaña M, Salvadori I, Samtleben DFE, Sanguineti M, Sapienza P, Schüssler F, Spurio M, Stolarczyk T, Taiuti M, Tayalati Y, Trovato A, Vallage B, Van Elewyck V, Versari F, Vivolo D, Wilms J, Zaborov D, Zornoza JD, and Zúñiga J
Abstract: One of the main objectives of the ANTARES telescope is the search for point-like neutrino sources. Both the pointing accuracy and the angular resolution of the detector are important in this context and a reliable way to evaluate this performance is needed. In order to measure the pointing accuracy of the detector, one possibility is to study the shadow of the Moon, i.e. the deficit of the atmospheric muon flux from the direction of the Moon induced by the absorption of cosmic rays. Analysing the data taken between 2007 and 2016, the Moon shadow is observed with 3.5 σ statistical significance. The detector angular resolution for downward-going muons is 0 . 73 ∘ ± 0 . 14 ∘ . The resulting pointing performance is consistent with the expectations. An independent check of the telescope pointing accuracy is realised with the data collected by a shower array detector onboard of a ship temporarily moving around the ANTARES location.
Published: 2018
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46. 'Chocolate' silver nanoparticles: Synthesis, antibacterial activity and cytotoxicity.

Author: Chowdhury NR, MacGregor-Ramiasa M, Zilm P, Majewski P, and Vasilev K
Subjects: Anti-Bacterial Agents pharmacology, Cell Survival drug effects, Dermis cytology, Dermis drug effects, Escherichia coli drug effects, Escherichia coli growth & development, Fibroblasts cytology, Fibroblasts drug effects, Humans, Metal Nanoparticles ultrastructure, Microbial Sensitivity Tests, Particle Size, Plant Extracts chemistry, Primary Cell Culture, Pseudomonas aeruginosa drug effects, Pseudomonas aeruginosa growth & development, Silver pharmacology, Silver Nitrate chemistry, Staphylococcus aureus drug effects, Staphylococcus aureus growth & development, Staphylococcus epidermidis drug effects, Staphylococcus epidermidis growth & development, Anti-Bacterial Agents chemical synthesis, Cacao chemistry, Metal Nanoparticles chemistry, Oxalic Acid chemistry, Silver chemistry
Abstract: Hypothesis: Silver nanoparticles (AgNPs) have emerged as a powerful weapon against antibiotic resistant microorganisms. However, most conventional AgNPs syntheses require the use of hazardous chemicals and generate toxic organic waste. Hence, in recent year's, plant derived and biomolecule based synthetics have has gained much attention. Cacao has been used for years for its medicinal benefits and contains a powerful reducing agent - oxalic acid. We hypothesized that, due to the presence of oxalic acid, cacao extract is capable of reducing silver nitrate (AgNO3) to produce AgNPs., Experiments: In this study, AgNPs were synthesized by using natural cacao extract as a reducing and stabilizing agent. The reaction temperature, time and reactant molarity were varied to optimize the synthesis yield., Findings: UV-visible spectroscopy (UV-vis), dynamic light scattering (DLS) and transmission electron microscopy (TEM) characterization demonstrated that the synthesized AgNPs were spherical particles ranging in size from 35 to 42.5nm. The synthesized AgNPs showed significant antibacterial activity against clinically relevant pathogens such as Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Staphylococcus epidermidis. Importantly, these green AgNPs are not cytotoxic to human dermal fibroblasts (HDFs) at concentrations below 32μg/ml. We conclude that cacao-based synthesis is a reproducible and sustainable method for the generation of stable antimicrobial silver nanoparticles with low cytotoxicity to human cells. The AgNPs synthesized in this work have promising properties for applications in the biomedical field., (Copyright © 2016 Elsevier Inc. All rights reserved.)
Published: 2016
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47. Comparison of a novel bilayered medium with the conventional media for cultivation of Mycobacterium tuberculosis.

Author: Bhattacharya S, Roy R, Chowdhury NR, Dasgupta A, and Dastidar SG
Subjects: Humans, Microbial Sensitivity Tests, Mycobacterium tuberculosis drug effects, Mycobacterium tuberculosis growth & development, Tuberculosis diagnosis, Tuberculosis microbiology, Bacteriological Techniques methods, Culture Media, Mycobacterium tuberculosis isolation & purification
Abstract: Background & Objective: There is resurgence of tuberculosis in recent years in spite of availability of comprehensive multidrug therapy. Conventional culture media require a long time for the appearance of growth of Mycobacterium tuberculosis, while the other methods are expensive. Hence, a rapid low cost and safe bilayered medium was developed for early growth and sensitivity testing of M. tuberculosis and the results were compared with those on Lowenstein Jensen medium, Middlebrook 7H10 and Kirchner's liquid media., Methods: A specially designed bilayered medium, consisting of a lower layer of Lowenstein Jensen medium without malachite green and a top layer of Middlebrook 7H 10 medium with added antibiotics and antifungal agents was prepared. Sputum from clinically suspected cases of tuberculosis, pleural fluid and pus samples were inoculated on the bilayered medium along with the inoculation on other conventional media after proper decontamination and concentration of the samples. Antibiotic sensitivity pattern was determined against a few rapidly growing control and test strains by disc diffusion technique and the results could be recorded by 3 to 7 days., Results: Statistically significant (P< 0.001) isolation rate was obtained on this bilayered medium when compared with the other three media, being 81.7 per cent growth by 7 days. Antibiotic sensitivity test could be recorded by 3 days in case of the rapidly growing strains on this medium, and by 7 days in case of M. tuberculosis strains., Interpretation & Conclusion: Bilayered medium produced rapid growth earliest by 48 h, higher isolation rates were achieved as compared to the other conventional media and drug sensitivity testing could also be carried out successfully. Thus, the bilayered medium can be used for obtaining early culture report.
Published: 2009

48. Cell culture models and animal models of viral hepatitis. Part II: hepatitis C.

Author: Guha C, Lee SW, Chowdhury NR, and Chowdhury JR
Subjects: Animals, Cell Culture Techniques, Hepatocytes immunology, Hepatocytes virology, Mice, Virus Replication, Disease Models, Animal, Hepacivirus, Hepatitis C, Mice, Transgenic virology, Pan troglodytes virology, Saguinus virology, Tupaiidae virology
Abstract: The lack of a preventive vaccine, coupled with common unresponsiveness to treatment and coinfection with HIV, has made HCV a major threat to public health. The authors review in vitro and in vivo models that are being used to study HCV and to develop new treatments and preventive measures.
Published: 2005
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49. Hepatocyte transplantation: state of the art and strategies for overcoming existing hurdles.

Author: Lee SW, Wang X, Chowdhury NR, and Roy-Chowdhury J
Subjects: Animals, Cell Transplantation adverse effects, Chronic Disease, Clinical Trials as Topic, Disease Models, Animal, Graft Rejection, Graft Survival, Humans, Liver Failure diagnosis, Liver Failure surgery, Liver Failure, Acute diagnosis, Prognosis, Research standards, Research trends, Risk Assessment, Severity of Illness Index, Survival Rate, Tissue Donors, Treatment Outcome, Cell Transplantation methods, Hepatocytes transplantation, Liver Failure, Acute surgery, Liver Regeneration physiology
Abstract: Over three decades of research in experimental animals and several clinical trials have brought us to the threshold of hepatocyte transplantation for the treatment of acute and chronic liver failure, and inherited metabolic disorders. However, more extensive clinical studies and routine clinical application are hampered by the shortage of good quality of donor cells. To overcome these hurdles, current research has focused on the search for alternatives to adult primary hepatocytes, such as liver cell progenitors, fetal hepatoblasts, embryonic, bone marrow or umbilical cord blood stem cells and conditionally immortalized hepatocytes. Cross-species hepatocyte transplantation is also being explored. It is hoped that ongoing research will permit the application of hepatocyte transplantation to the treatment of a wide array of liver diseases.
Published: 2004

50. Assessment of evolution of pandemic Vibrio parahaemolyticus by multilocus sequence typing.

Author: Chowdhury NR, Stine OC, Morris JG, and Nair GB
Subjects: Genes, Bacterial genetics, Genetic Variation, Molecular Sequence Data, Serotyping methods, Vibrio Infections epidemiology, Vibrio parahaemolyticus genetics
Abstract: The genetic relatedness of 81 isolates of Vibrio parahaemolyticus was assessed by multilocus sequence typing. The strain with serotype O3:K6 emerged as a pandemic pathogen in 1996, with subsequent expansion to include strains having serotypes O1:KUT, O4:K68, and O1:K25. Sequence data from gyrB, recA, dnaE, and gnd revealed that 16 distinct serogroups isolated prior to the pandemic were highly variable and only isolates of serogroup O3:K6 shared two alleles with the pandemic strains. The pandemic strains regardless of serotype were clonal, with 51 of 54 isolates having the identical allelic profile (AP). Serotype alone did not adequately define a pandemic strain: among O1:KUT strains tested, seven strains with the identical pandemic AP carried previously described pandemic markers, while five nonpandemic strains had five distinct APs. Our sequence data provide strong molecular support for the clonal origin of pandemic V. parahaemolyticus O3:K6 and suggest that strains within such a clonal group may acquire previously identified serotypes.
Published: 2004
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