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358 results on '"Chowdhury, Rajdeep"'

12. Understanding cancer complexome using networks, spectral graph theory and multilayer framework

Author

Rai, Aparna, Pradhan, Priodyuti, Nagraj, Jyothi, Lohitesh, K., Chowdhury, Rajdeep, and Jalan, Sarika

Subjects
Quantitative Biology - Molecular Networks
Abstract

Cancer complexome comprises a heterogeneous and multifactorial milieu that varies in cytology, physiology, signaling mechanisms and response to therapy. The combined framework of network theory and spectral graph theory along with the multilayer anal- ysis provides a comprehensive approach to analyze the proteomic data of seven different cancers, namely, breast, oral, ovarian, cervical, lung, colon and prostate. Our analysis demonstrates that the protein-protein interaction networks of the normal and the cancerous tissues associated with the seven cancers have overall similar structural and spectral properties. However, few of these properties implicate unsystematic changes from the normal to the disease networks depicting difference in the interactions and highlighting changes in the complexity of different cancers. Importantly, analysis of common proteins of all the cancer networks reveals few proteins namely the sensors, which not only occupy significant position in all the layers but also have direct involvement in causing cancer. The prediction and analysis of miRNAs targeting these sensor proteins hint towards the possible role of these proteins in tumorigenesis. This novel approach helps in understanding cancer at the fundamental level and provides a clue to develop promising and nascent concept of single drug therapy for multiple diseases as well as personalized medicine., Comment: 25 pages, 6 figures, accepted in scientific reports (in press)

Published
2017
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13. LncRNA HULC augments high glucose‐associated pancreatic cancer progression and drug resistance by enhancing YAP activity and autophagy.

Author

Sharma, Ankita, Chowdhury, Shibasish, Mukherjee, Sudeshna, and Chowdhury, Rajdeep

Subjects
DRUG resistance in cancer cells, YAP signaling proteins, PANCREATIC duct, LIVER cancer, PANCREATIC cancer
Abstract

Background Information: One of the confounding factors in pancreatic cancer (PC) pathogenesis is hyperglycemia. The molecular mechanism by which high glucose (HG) influences PC severity is poorly understood. Our investigation delved into the impact of lncRNA highly upregulated in liver cancer (HULC) and its interaction with yes‐associated protein (YAP) in regulating the fate of pancreatic ductal adenocarcinoma cells (PDAC) under HG‐induced conditions. PDAC cells were cultured under normal or HG conditions. We thereafter measured the effect of HG on the viability of PDAC cells, their migration potential and drug resistance properties. The lncRNAs putatively dysregulated in PC and diabetes were shortlisted by bioinformatics analysis followed by wet lab validation of function. Results: HG led to enhanced proliferation and drug refractoriness in PDAC cells. HULC was identified as one of the major deregulated lncRNAs following bioinformatics analysis. HULC was found to regulate the expression of the potent transcriptional regulator – YAP through selective histone modifications at the YAP promoter. siRNA‐mediated ablation of HULC resulted in a concurrent decrease in YAP transcriptional activity. Importantly, HULC and YAP were found to co‐operatively regulate the cellular homeostatic process autophagy, thus inculcating drug resistance and proliferative potential in PDAC cells. Moreover, inhibition of autophagy or YAP led to a decrease in HULC levels, suggesting the existence of an inter‐regulatory feedback loop. Conclusions: We observed that HG triggers aggressive properties in PDAC cells. Mechanistically, up‐regulation of lncRNA HULC resulted in activation of YAP and differential regulation of autophagy coupled to increased proliferation of PDAC cells. Significance: Inhibition of HULC and YAP may represent a novel therapeutic strategy for PDAC. Furthermore, this study portrays the intricate molecular interplay between HULC, YAP and autophagy in PDAC pathogenesis. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Project Management Method-Based Cryptographic Algorithm Employing IC Engine Transmission Ratio and Simple Interest Formula

Author

Chowdhury, Rajdeep, Kumari, Smriti, Kumar, Sukhwant, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Singh, Pradeep Kumar, editor, Singh, Yashwant, editor, Kolekar, Maheshkumar H., editor, Kar, Arpan Kumar, editor, Chhabra, Jitender Kumar, editor, and Sen, Abhijit, editor

Published
2021
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15. Design and Implementation of Cryptographic Technique Employing Intricate Table and Rubik Rotation Algorithm

Author

Chowdhury, Rajdeep, Sharma, Soma, Alam, Md Adil, Niharika, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Tavares, João Manuel R. S., editor, Chakrabarti, Satyajit, editor, Bhattacharya, Abhishek, editor, and Ghatak, Sujata, editor

Published
2021
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17. Comprehensive Operation of Personalized Astute Wheelchair Having Portable Rooftop and Integrated Piezoelectric Engendered Tires to Assist Societal Advance

Author

Chowdhury, Rajdeep, Poddar, Kaushal Kumar, kumar, Sukhwant, Alam, Md Adil, Ahmed, Neyaz, Som, Madhurima, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Hassanien, Aboul Ella, editor, Bhattacharyya, Siddhartha, editor, Chakrabati, Satyajit, editor, Bhattacharya, Abhishek, editor, and Dutta, Soumi, editor

Published
2021
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18. Prospective SD–WAN Shift: Newfangled Indispensable Industry Driver

Author

Sinha, Sudip, Chowdhury, Rajdeep, Das, Anirban, Ghosh, Amitava, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Borah, Samarjeet, editor, Pradhan, Ratika, editor, Dey, Nilanjan, editor, and Gupta, Phalguni, editor

Published
2021
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19. Employment of Cryptographic Modus Operandi Based on Trigonometric Algorithm and Resistor Color Code

Author

Chowdhury, Rajdeep, Kumar, Sukhwant, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Hassanien, Aboul Ella, editor, Bhatnagar, Roheet, editor, and Darwish, Ashraf, editor

Published
2021
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37. One-Pot Synthesis of Vinylogous Cyano Aminoaryls (VinCAs) as Benzenic Fluorophores: Tailoring Diverse Emission Colors for White Light Emitting Materials and Cell Imaging

Author

Ghosh, Saurajit, Kumar, Shubham, Suneesh, Swathi, Bhambri, Himanshi, Mandal, Sanjay K., Ghosh, Sarbani, Chowdhury, Rajdeep, and Addy, Partha Sarathi

Abstract

Donor–acceptor-based organic small molecules with an electronic push–pull effect can demonstrate intramolecular charge transfer to show interesting photoluminescence properties. This is an essential criterion for designing fluorogenic probes for cell imaging studies and the development of organic light-emitting diodes. Now, to design such optical materials sometimes it is necessary to tune the band gap by controlling the energies of the highest occupied molecular orbital and lowest unoccupied molecular orbital. Typically, the band gaps could be modulated by installing unsaturated handles between electron-rich donors and electron-deficient acceptors. However, these methods are often synthetically and economically challenging due to the involvement of expensive catalysts and difficult reaction setups. In our present study, we show a straightforward, cost-effective method for obtaining a series of donor–acceptor-type Vinylogous Cyano Aminoaryls (VinCAs) with diverse emission colors. Further studies reveal that these VinCAs can serve as effective cell imaging agents, showcasing potential use in chemical biology. Additionally, these molecules could be further used to generate white light emission (WLE), showing their potential utility in advanced lighting technologies.

Published
2024
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