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147 results on '"Chougule, Mahavir B."'

2. List of Contributors

Author

Amrutiya, Jitendra, primary, Bahadur, Pratap, additional, Baradia, Dipesh, additional, Bardoliwala, Denish, additional, Bhatt, Priyanka, additional, Bhowmick, Subhas, additional, Chougule, Mahavir B., additional, Dabke, Amit, additional, Ghosh, Saikat, additional, Haware, Rahul V., additional, Inamdar, Nazma, additional, Inamdar, Nazma N., additional, Javia, Ankit, additional, Khatri, Nirav, additional, Kolte, Atul, additional, Kore, Girish, additional, Kotha, Arun K., additional, Kuperkar, Ketan, additional, Lalan, Manisha S., additional, Lalani, Rohan, additional, Mahajan, Ashok, additional, Mishra, Pooja, additional, Misra, Ambikanandan, additional, Mourya, Vishnukant, additional, Mourya, Vishnukant K., additional, Patel, Akanksha, additional, Patel, Deepa, additional, Patel, Vivek N., additional, Pathak, Anjali, additional, Pathak, Drashti, additional, Patil, Sushilkumar, additional, Rathi, Mohan, additional, Samant, Rajan, additional, Shahiwala, Aliasgar, additional, Surti, Naazneen, additional, Talele, Dipali, additional, Tandel, Hemal, additional, Tiwari, Sanjay, additional, Trehan, Sonia, additional, Vhora, Imran, additional, Vinjamuri, Bhavani Prasad, additional, and Yewale, Chetan, additional

Published
2021
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5. List of Contributors

Author

Chauhan, Abhay S., primary, Chougule, Mahavir B., additional, Deb, Pran Kishore, additional, Paradkar, Anant, additional, Chandrasekaran, Balakumar, additional, Choudhury, Hira, additional, Ghode, Piyush, additional, Gorain, Bapi, additional, Gour, Vishal, additional, Mishra, Dinesh K., additional, Abed, Sara Nidal, additional, Pandey, Vikas, additional, Al-Attraqchi, Omar, additional, Hardenia, Shiv Shankar, additional, Jain, Priyanka, additional, Kar, Mousumi, additional, Jamal, Saadh Mohamed, additional, Asati, Saket, additional, Kokaz, Sarah Falah, additional, Shukla, Tripti, additional, Deshpande, Ashwini, additional, Surchi, Hiba Salim, additional, Maheshwari, Neha, additional, Tambe, Vishakha, additional, Bandopadhyay, Shantanu, additional, Bhatt, Shailendra, additional, Chourasiya, Yashu, additional, Dhote, Kanika, additional, Dhote, Vinod Kumar, additional, Dwivedi, Sunil Kumar, additional, Raval, Nidhi, additional, Hardenia, Anu, additional, Joshi, Garima, additional, Kalyane, Dnyaneshwar, additional, Kapoor, Devesh, additional, Kumar, Manish, additional, Maheshwari, Rahul, additional, Yadav, Khushwant S., additional, Pandey, Sharad Prakash, additional, Tiwari, Rahul, additional, Pethe, Anil M., additional, Soni, Vandana, additional, Youngren-Ortiz, Susanne R., additional, and Tekade, Rakesh K., additional

Published
2019
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7. List of Contributors

Author

Deb, Pran Kishore, primary, Shnoudeh, Abeer, additional, Chougule, Mahavir B., additional, Abed, Sara Nidal, additional, Gorain, Bapi, additional, Choudhury, Hira, additional, Al-Najjar, Belal O., additional, Soni, Vandana, additional, Madheswaran, Thiagarajan, additional, Acharya, Pratap Chandra, additional, Al-Attraqchi, Omar, additional, Amarji, Basant, additional, Anil Kumar Ravipati, N.V., additional, Indurkhya, Arpna, additional, Jaber, Abdulmuttaleb Yousef, additional, Chandra, Akhilesh, additional, Choudhury, Anup Avijit, additional, Bairagi, Ujjawal, additional, Fernandes, Clara, additional, Mallik, Santanu, additional, Manchanda, Satish, additional, Kesharwani, Prashant, additional, Ghosh, Rajat, additional, Maheshwari, Rahul, additional, Asati, Saket, additional, Bandopadhyay, Shantanu, additional, Bandyopadhyay, Nabamita, additional, Kuche, Kaushik, additional, Chourasiya, Yashu, additional, Mane, Ankita, additional, Marwein, Sarapynbiang, additional, Mehtani, Disha, additional, Mishra, Bijayashree, additional, Pandey, Vikas, additional, Patel, Mahendra, additional, Prasad, Mailavaram Raghu, additional, Raval, Nidhi, additional, Seth, Ankit, additional, Shakya, Ashok K., additional, Sharma, Piyoosh, additional, Shetty, Saritha, additional, Pal, Yogendra, additional, Suares, Divya, additional, Tambe, Vishakha, additional, Taneja, Neha, additional, Todke, Pooja, additional, Vora, Amisha, additional, Singh, Chhater, additional, Soni, Neetu, additional, Naik, Rajashri R., additional, Pandey, Manisha, additional, Devadasu, Venkat Ratnam, additional, Tekade, Muktika, additional, and Tekade, Rakesh K., additional

Published
2018
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8. List of Contributors

Author

Abnous, Khalil, primary, Alibolandi, Mona, additional, Butt, Arthur M., additional, Charbgoo, Fahimeh, additional, Chaurasia, Mohini, additional, Choudhury, Hira, additional, Chougule, Mahavir B., additional, Chourasia, Manish K., additional, Ding, Zhiying, additional, Elkhodairy, Kadria A., additional, Elzoghby, Ahmed O., additional, Fadel, Hassen, additional, Figueiredo, Melina F., additional, Freag, May S., additional, Gorain, Bapi, additional, Gothwal, Avinash, additional, Gupta, Umesh, additional, Jiang, Yan, additional, Jiang, Yueyao, additional, Kesharwani, Prashant, additional, Khan, Iliyas, additional, Kumar, Mukesh, additional, Lalatsa, Aikaterini, additional, Leite, Diana M., additional, Liu, Xianhong, additional, Lv, Wei, additional, Maheshwari, Rahul, additional, Martins-Gomes, C., additional, Meher, Jaya G., additional, Michelhaugh, Sharon K., additional, Mittal, Sandeep, additional, Mohd Amin, Mohd Cairul Iqbal, additional, O’Connor, Max, additional, Pandey, Manisha, additional, Parajuli, Prahlad, additional, Patel, Archita J., additional, Patel, Meghal D., additional, Patel, Samir G., additional, Ramezani, Mohammad, additional, Sadry, Neema, additional, Sharma, Piyoosh, additional, Shrivastava, Sushant K., additional, Silva, A.M., additional, Singh, Anita, additional, Singh, Bhupinder, additional, Singh, K.K., additional, Souto, E.B., additional, Suryadevara, Raviteja, additional, Taghdisi, Seyed M., additional, Teixeira, M.C., additional, Tekade, Muktika, additional, Tekade, Rakesh K., additional, Thakur, Chitra, additional, Veiga, F.J., additional, Xin, Hongliang, additional, and Xu, Jianpei, additional

Published
2018
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15. List of Contributors

Author

Abdelghany, Sara, primary, Amjad, Muhammad W., additional, Anwar, Firoz, additional, Athawale, R., additional, Augustine, Rimesh, additional, Beg, Sarwar, additional, Butt, Adeel M., additional, Chaudhary, Sonam, additional, Chougule, Mahavir B., additional, Derakhshan, Mohammad A., additional, Gajbhiye, Virendra, additional, Giri, Namita, additional, Gothwal, Avinash, additional, Greish, Khaled, additional, Gupta, Vivek, additional, Gupta, Umesh, additional, Gurnany, Ekta, additional, Jain, Atul, additional, Jain, Ashay, additional, Jasim, Anfal, additional, John, Johnson V., additional, Kaur, Ripandeep, additional, Kesharwani, Prashant, additional, Khan, Iliyas, additional, Khurana, Rajneet K., additional, Kiani, Vali, additional, Kim, I.L, additional, Kumar, Lalit, additional, Kumar, Rajendra, additional, Kumar, Vikas, additional, Kurup, N., additional, Lohan, Shikha, additional, Maheshwari, Rahul, additional, Mansoori, Mohammad H., additional, Mishra, Vijay, additional, Mohd Amin, Mohd C.I., additional, Rahman, Mahfoozur, additional, Rani, Sarita, additional, Rezayat, Seyed M., additional, Saini, Sumant, additional, Samad, Abdus, additional, Sharma, Ashok K., additional, Shegokar, R., additional, Singh, Bhupinder, additional, Soni, Namrata, additional, Tavakol, Behnaz, additional, Tavakol, Shima, additional, Tekade, Muktika, additional, Tekade, Rakesh K., additional, Vaidya, Bhuvaneshwar, additional, Verma, Amita, additional, Verma, Shivani, additional, and Yang, R., additional

Published
2017
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28. Structural and Surface Properties of Polyamidoamine (PAMAM) – Fatty Acid‐based Nanoaggregates Derived from Self‐assembling Janus Dendrimers

Author

Yaddehige, Mahesh Loku, primary, Chandrasiri, Indika, additional, Barker, Abigail, additional, Kotha, Arun K., additional, Dal Williams, Jon Steven, additional, Simms, Briana, additional, Kucheryavy, Pavel, additional, Abebe, Daniel G., additional, Chougule, Mahavir B., additional, and Watkins, Davita L., additional

Published
2020
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36. The Daniel K. Inouye College of Pharmacy Scripts: Targeted Nanocarrier Based Systems for the Treatment of Lung Cancer

Author

Youngren-Ortiz, Susanne R and Chougule, Mahavir B

Subjects
Lung Neoplasms, Nanocapsules, Humans, Antineoplastic Agents, Articles, RNA, Small Interfering
Abstract

In Hawai'i, lung cancer is among the top cancers diagnosed and a leading cause of death. Despite current understanding and modern surgery, radiology, and chemotherapy techniques, the survival of those suffering from lung cancer remains low. Current anticancer drugs have poor tumor tissue selectivity and toxicity issues that contribute to their overall low efficacy, detrimental effects to normal tissues, and drug resistance. A potential way of mitigating cancer is through RNA interference (RNAi) by the delivery of small interfering RNA (siRNA) to target select proteins or genes involved in cancer progression, known as oncoproteins or oncogenes, respectively. However, the clinical utility of delivering unformulated siRNA has been hindered due to poor cell penetration, nonspecific effects, rapid degradation, and short half-life. As an alternate for conventional chemotherapy, nanoparticles (AKA nanocarriers) may be designed to localize within the tumor environment and increase targeted cell internalization, thus reducing systemic adverse effects and increasing efficacy. Nanoparticles play important roles in drug delivery and have been widely studied for cancer therapy and diagnostics, termed collectively as theranostics. Nanoparticles composed of natural and artificial polymers, proteins, lipids, metals, and carbon-based materials have been developed for the delivery of siRNA. Cancer targeting has been improved by nanoparticle surface modification or conjugation with biomolecules that are attracted to or stimulate therapeutic agent release within cancer tissues or cells. In this mini-review article, we present recent progress in nanocarrier-mediated siRNA delivery systems that include lipid, polymer, metallic and carbon-based nanoparticles for lung cancer therapy.

Published
2017

40. Formulation Strategies of Nano Lipid Carrier for Effective Brain Targeting of Anti-AD Drugs

Author

Alexander, Amit, Agrawal, Mukta, Saraf, Swarnlata, Saraf, Shailendra, Ajazuddin, and Chougule, Mahavir B.

Abstract

NLC is a next-generation lipid nanocarrier, which holds many advantages over other colloidal lipid carrier systems like higher drug loading, better and controlled release and enhanced stability. Owing to the unique structural composition, i.e. crystallized solid and liquid lipid blend, it offers excellent biocompatibility and higher permeation across physiological membranes like BBB. Moreover, the surface of NLC can easily be modified with target-specific ligands, proteins, peptides, etc. which makes it a potential candidate for brain targeting of CNS acting drugs. NLC has found various applications for the treatment of various CNS disorders including Alzheimer’s disease, Parkinson’s disease, schizophrenia, epilepsy, migraine, cerebral ischemia, etc. Among these, the application of NLC towards the treatment of AD has been well-explored in the past two decades. In this piece of work, we have discussed the types of NLC, its composition, fabrication techniques, characterization, stability profile and application in the treatment of AD.

Published
2020
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41. Physical properties and solubility studies of Nifedipine-PEG 1450/HPMCAS-HF solid dispersions.

Author

Haware, Rahul V., Vinjamuri, Bhavani Prasad, Gavireddi, Monika, Dave, Vivek S., Gupta, Deepak, Chougule, Mahavir B., and Stagner, William C.

Subjects
NIFEDIPINE, POLYETHYLENE glycol, FOURIER transform infrared spectroscopy, X-ray diffraction, CRYSTALLIZATION
Abstract

Low-order high-energy nifedipine (NIF) solid dispersions (SDs) were generated by melt solvent amorphization with polyethylene glycol (PEG) 1450 and hypromellose acetate succinate (HPMCAS-HF) to increase NIF solubility while achieving acceptable physical stability. HPMCAS-HF was used as a crystallization inhibitor. Individual formulation components, their physical mixtures (PMs), and SDs were characterized by differential scanning calorimetry, powder X-ray diffraction, and Fourier transform infrared spectroscopy (FTIR). NIF solubility and percent crystallinity (PC) were determined at the initial time and after 5 days stored at 25 °C and 60% RH. FTIR indicated that hydrogen bonding was involved with the amorphization process. FTIR showed that NIF:HPMCAS-HF intermolecular interactions were weaker than NIF:PEG 1450 interactions. NIF:PEG 1450 SD solubilities were significantly higher than their PM counterparts (p < 0.0001). The solubilities of NIF:PEG 1450:HPMCAS-HF SDs were significantly higher than their corresponding NIF:PEG 1450 SDs (p < 0.0001-0.043). All the SD solubilities showed a statistically significant decrease (p < 0.0001) after storage for 5 days. SDs PC were statistically lower than their comparable PMs (p < 0.0001). The PCs of SDs with HPMCAS-HF were significantly lower than SDs not containing only PEG 1450. All SDs exhibited a significant increase in PC (p < 0.0001–0.0089) on storage. Thermogravimetric analysis results showed that HPMCAS-HF bound water at higher temperatures than PEG 1450 (p < 0.0001–0.0039). HPMCAS-HF slowed the crystallization process of SDs, although it did not completely inhibit NIF crystal growth. [ABSTRACT FROM AUTHOR]

Published
2019
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49. Targeted Nanocarrier Based Systems for the Treatment of Lung Cancer.

Author

Youngren-Ortiz, Susanne R. and Chougule, Mahavir B.

Abstract

In Hawai‘i, lung cancer is among the top cancers diagnosed and a leading cause of death. Despite current understanding and modern surgery, radiology, and chemotherapy techniques, the survival of those suffering from lung cancer remains low. Current anticancer drugs have poor tumor tissue selectivity and toxicity issues that contribute to their overall low efficacy, detrimental effects to normal tissues, and drug resistance. A potential way of mitigating cancer is through RNA interference (RNAi) by the delivery of small interfering RNA (siRNA) to target select proteins or genes involved in cancer progression, known as oncoproteins or oncogenes, respectively. However, the clinical utility of delivering unformulated siRNA has been hindered due to poor cell penetration, nonspecific effects, rapid degradation, and short half-life. As an alternate for conventional chemotherapy, nanoparticles (AKA nanocarriers) may be designed to localize within the tumor environment and increase targeted cell internalization, thus reducing systemic adverse effects and increasing efficacy. Nanoparticles play important roles in drug delivery and have been widely studied for cancer therapy and diagnostics, termed collectively as theranostics. Nanoparticles composed of natural and artificial polymers, proteins, lipids, metals, and carbon-based materials have been developed for the delivery of siRNA. Cancer targeting has been improved by nanoparticle surface modification or conjugation with biomolecules that are attracted to or stimulate therapeutic agent release within cancer tissues or cells. In this mini-review article, we present recent progress in nanocarrier-mediated siRNA delivery systems that include lipid, polymer, metallic and carbon-based nanoparticles for lung cancer therapy. [ABSTRACT FROM AUTHOR]

Published
2017

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