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5. Identification of Human Case of Avian Influenza A(H5N1) Infection, India

Author

Potdar, Varsha, Brijwal, Megha, Lodha, Rakesh, Yadav, Pragya, Jadhav, Santosh, Choudhary, Manohar Lal, Choudhary, Aashish, Vipat, Veena, Gupta, Nivedita, Deorari, Ashok Kumar, Dar, Lalit, and Abraham, Priya

Subjects
Avian influenza -- Case studies -- Diagnosis, Communicable diseases in children -- Case studies -- Diagnosis, Pediatric research, Health
Abstract

Avian influenza viruses remain major threats worldwide, responsible for multiple outbreaks among poultry and episodes of transmission to humans. During January 2003-February 3, 2022, there were 862 reported cases of [...]

Published
2022
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6. Effectiveness of an inactivated virus-based SARS-CoV-2 vaccine, BBV152, in India: a test-negative, case-control study

Author

Desai, Devashish, Khan, Adil Rashid, Soneja, Manish, Mittal, Ankit, Naik, Shivdas, Kodan, Parul, Mandal, Ayan, Maher, Ganesh Tarachand, Kumar, Rohit, Agarwal, Ayush, Gowda, Naveen R, H, Vikas, Kumar, Parmeshwar, Pandey, Shivam, Pandey, R M, Kumar, Arvind, Ray, Animesh, Jorwal, Pankaj, Nischal, Neeraj, Choudhary, Aashish, Brijwal, Megha, Madan, Karan, Lodha, Rakesh, Sinha, Sanjeev, Dar, Lalit, Wig, Naveet, and Guleria, Randeep

Published
2022
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11. Virological and cytological changes in tears and conjunctiva of patients with COVID-19

Author

Angmo, Dewang, Mahalingam, Karthikeyan, Kakkar, Aanchal, Rathod, Aishwarya, Meena, Suman, Kaur, Avneet, Choudhary, Aashish, Sharma, Puneet, Dar, Lalit, Samaddar, Arpan, Trikha, Anjan, Saxena, Rohit, Titiyal, Jeewan, and Sharma, Namrata

Subjects
Virulence (Microbiology) -- Analysis, Eye diseases -- Risk factors -- Prevention, Tearing -- Composition, Conjunctiva -- Analysis, Health
Abstract

Byline: Dewang. Angmo, Karthikeyan. Mahalingam, Aanchal. Kakkar, Aishwarya. Rathod, Suman. Meena, Avneet. Kaur, Aashish. Choudhary, Puneet. Sharma, Lalit. Dar, Arpan. Samaddar, Anjan. Trikha, Rohit. Saxena, Jeewan. Titiyal, Namrata. Sharma Purpose: [...]

Published
2023

14. Poor outcomes in patients with cirrhosis and Corona Virus Disease-19

Author

Shalimar, Elhence, Anshuman, Vaishnav, Manas, Kumar, Ramesh, Pathak, Piyush, Soni, Kapil Dev, Aggarwal, Richa, Soneja, Manish, Jorwal, Pankaj, Kumar, Arvind, Khanna, Puneet, Singh, Akhil Kant, Biswas, Ashutosh, Nischal, Neeraj, Dar, Lalit, Choudhary, Aashish, Rangarajan, Krithika, Mohan, Anant, Acharya, Pragyan, Nayak, Baibaswata, Gunjan, Deepak, Saraya, Anoop, Mahapatra, Soumya, Makharia, Govind, Trikha, Anjan, and Garg, Pramod

Published
2020
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17. The “Investigating and translating genomic evidence for public health response to SARS-CoV-2 (INSIDE SARS-CoV-2)” project – Network of excellence.

Author

Di Martino, Angela, Bhattacharyya, Sankar, Riccardo, Flavia, Pandey, Rajesh, Chiara, Matteo, Mani, Shailendra, Pezzotti, Patrizio, Presti, Alessandra Lo, Ambrosio, Luigina, Marziano, Valentina, Poletti, Piero, Pesole, Graziano, Narayan, Jitendra, Brijwal, Megha, Choudhary, Aashish, Tramuto, Fabio, Mazzucco, Walter, Agrawal, Anurag, Mohan, Anant, and Stefanelli, Paola

Published
2024
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18. Nasal shedding of vaccine viruses after immunization with a Russian‐backbone live attenuated influenza vaccine in India

Author

Dar, Lalit, primary, Krishnan, Anand, additional, Kumar, Ramesh, additional, Dhakad, Shivram, additional, Choudekar, Avinash, additional, Bagga, Sumedha, additional, Sharma, Amrit, additional, Kumar, Amit, additional, Jethani, Jyoti, additional, Saha, Siddhartha, additional, Amarchand, Ritvik, additional, Kumar, Rakesh, additional, Choudhary, Aashish, additional, Narayan, Venkatesh Vinayak, additional, Gopal, Giridara, additional, Lafond, Kathryn E., additional, and Lindstrom, Stephen, additional

Published
2023
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19. Efficacy of live attenuated and inactivated influenza vaccines among children in rural India: A 2-year, randomized, triple-blind, placebo-controlled trial

Author

Krishnan, Anand, Dar, Lalit, Saha, Siddhartha, Narayan, Venkatesh Vinayak, Kumar, Rakesh, Kumar, Ramesh, Amarchand, Ritvik, Dhakad, Shivram, Chokker, Reshmi, Choudekar, Avinash, Gopal, Giridara, Choudhary, Aashish, Potdar, Varsha, Chadha, Mandeep, Lafond, Kathryn E., Lindstrom, Stephen, Widdowson, Marc-Alain, and Jain, Seema

Subjects
Rural children -- Health aspects, Influenza vaccines -- Testing -- Patient outcomes, Influenza -- Prevention, Pediatric research, Biological sciences
Abstract

Background Influenza is a cause of febrile acute respiratory infection (FARI) in India; however, few influenza vaccine trials have been conducted in India. We assessed absolute and relative efficacy of live attenuated influenza vaccine (LAIV) and inactivated influenza vaccine (IIV) among children aged 2 to 10 years in rural India through a randomized, triple-blind, placebo-controlled trial conducted over 2 years. Methods and findings In June 2015, children were randomly allocated to LAIV, IIV, intranasal placebo, or inactivated polio vaccine (IPV) in a 2:2:1:1 ratio. In June 2016, vaccination was repeated per original allocation. Overall, 3,041 children received LAIV (n = 1,015), IIV (n = 1,010), nasal placebo (n = 507), or IPV (n = 509). Mean age of children was 6.5 years with 20% aged 9 to 10 years. Through weekly home visits, nasal and throat swabs were collected from children with FARI and tested for influenza virus by polymerase chain reaction. The primary outcome was laboratory-confirmed influenza-associated FARI; vaccine efficacy (VE) was calculated using modified intention-to-treat (mITT) analysis by Cox proportional hazards model (PH) for each year. In Year 1, VE was 40.0% (95% confidence interval (CI) 25.2 to 51.9) for LAIV and 59.0% (95% CI 47.8 to 67.9) for IIV compared with controls; relative efficacy of LAIV compared with IIV was -46.2% (95% CI -88.9 to -13.1). In Year 2, VE was 51.9% (95% CI 42.0 to 60.1) for LAIV and 49.9% (95% CI 39.2 to 58.7) for IIV; relative efficacy of LAIV compared with IIV was 4.2% (95% CI -19.9 to 23.5). No serious adverse vaccine-attributable events were reported. Study limitations include differing dosage requirements for children between nasal and injectable vaccines (single dose of LAIV versus 2 doses of IIV) in Year 1 and the fact that immunogenicity studies were not conducted. Conclusions In this study, we found that LAIV and IIV vaccines were safe and moderately efficacious against influenza virus infection among Indian children. Trial registration Clinical Trials Registry of India CTRI/2015/06/005902., Author(s): Anand Krishnan 1,*, Lalit Dar 2, Siddhartha Saha 3, Venkatesh Vinayak Narayan 3, Rakesh Kumar 1, Ramesh Kumar 2, Ritvik Amarchand 1, Shivram Dhakad 2, Reshmi Chokker 1, Avinash [...]

Published
2021
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22. Clinical presentation, viral kinetics and management of human monkeypox cases from New Delhi, India 2022

Author

Relhan, Vineet, primary, Sahay, Rima R., additional, Shete, Anita M., additional, Choudhary, Aashish, additional, Yadav, Pragya D., additional, Sahoo, BL, additional, Brijwal, Megha, additional, Patil, Deepak Y., additional, Kumar, Suresh, additional, PS, Kannan Sabarinath, additional, Mohandas, Sreelekshmy, additional, and Abraham, Priya, additional

Published
2022
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25. Evaluation of sensitivity and specificity of high fluorescence lymphocyte count percentage of sysmex XN analyzer in diagnosis of dengue

Author

Brijwal, Megha, primary, Ningombam, Aparna, additional, Acharya, Shreyam, additional, Sarkar, Abhirup, additional, Kumar, Kundan, additional, Routray, Srimantinee, additional, Sachdev, Janya, additional, Srigyan, Deepankar, additional, Choudhary, Aashish, additional, Subramanian, Arulselvi, additional, and Dar, Lalit, additional

Published
2022
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28. Incidence, risk factors, and viral etiology of community-acquired acute lower respiratory tract infection among older adults in rural north India

Author

Kumar, Rakesh, primary, Dar, Lalit, additional, Amarchand, Ritvik, additional, Saha, Siddhartha, additional, Lafond, Kathryn E, additional, Purakayastha, Debjani R, additional, Kumar, Ramesh, additional, Choudekar, Avinash, additional, Gopal, Giridara, additional, Dhakad, Shivram, additional, Narayan, Venkatesh Vinayak, additional, Wahi, Abhishek, additional, Chhokar, Reshmi, additional, Lindstrom, Stephen, additional, Whitaker, Brett, additional, Choudhary, Aashish, additional, Dey, A B, additional, and Krishnan, Anand, additional

Published
2021
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30. Respiratory syncytial virus infection among adults after hematopoietic stem cell transplantation.

Author

Samad, Sameer, Jethani, Jyoti, Kumar, Lalit, Choudhary, Aashish, Brijwal, Megha, and Dar, Lalit

Subjects
RESPIRATORY syncytial virus infections, HEMATOPOIETIC stem cell transplantation, HUMAN metapneumovirus infection, STEM cell transplantation, HEMATOPOIETIC stem cells, RESPIRATORY syncytial virus
Abstract

Introduction: Respiratory syncytial virus (RSV) is a common cause of morbidity among hematopoietic stem cell transplant (HSCT) recipients, with RSV-associated lower respiratory tract infection carrying high mortality rates. There have been no large studies till date, describing the incidence, clinical features, and outcomes of RSV infection among adult HSCT recipients in India. Methods: A prospective cohort of 100 adults who underwent HSCT was followed up for a maximum period of 18 months starting from the date of transplantation for any episode of respiratory tract infectious disease (RTID). Respiratory samples were collected for laboratory confirmation of the presence and subtyping of RSV by real-time reverse transcriptase-polymerase chain reaction. Results: The study population comprised of 66% (66/100) males and 34% (34/100) females. Autologous HSCT recipients constituted 78% (78/100) and allogeneic HSCT recipients constituted 22% (22/100) of the study population. The incidence of RSV-RTID among adults after HSCT was 0.82/100 patient months. Most cases occurred during the winter season and the predominant subtype was RSV-A (9/11, 81.8%). Lower RTID was the most common clinical diagnosis made at presentation (9/11, 81.8%). Female gender was predictive of RSV-RTID (log rank P = 0.002). All the RSV-RTID episodes recovered completely without targeted therapy. Conclusion: RSV is a significant cause of morbidity among adult HSCT recipients in India. Prophylaxis and treatment measures need to be instituted after a proper risk-benefit assessment. Longitudinal studies with larger sample sizes are needed to confirm these results. [ABSTRACT FROM AUTHOR]

Published
2022
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31. Evaluation of sensitivity and specificity of high fluorescence lymphocyte count percentage of sysmex XN analyzer in diagnosis of dengue.

Author

Ningombam, Aparna, Acharya, Shreyam, Sarkar, Abhirup, Kumar, Kundan, Brijwal, Megha, Routray, Srimantinee, Sachdev, Janya, Srigyan, Deepankar, Choudhary, Aashish, Subramanian, Arulselvi, and Dar, Lalit

Subjects
STATISTICS, KRUSKAL-Wallis Test, DENGUE, IMMUNOGLOBULINS, FEVER, CONFIDENCE intervals, AUTOANALYZERS, SERUM, SERODIAGNOSIS, ONE-way analysis of variance, FLUORESCENCE spectroscopy, BLOOD collection, RETROSPECTIVE studies, RISK assessment, COMPARATIVE studies, PLATELET count, DESCRIPTIVE statistics, ENZYME-linked immunosorbent assay, SENSITIVITY & specificity (Statistics), THROMBOCYTOPENIA, DATA analysis, RECEIVER operating characteristic curves, DATA analysis software, LYMPHOCYTE count, DISEASE risk factors, EVALUATION
Abstract

BACKGROUND: The Sysmex XN-series hematology analyzers provide newer parameters including high fluorescence lymphocyte cell percentage (HFLC%) which correlates with the presence of atypical lymphocytes in peripheral blood. We aimed to analyze the sensitivity and specificity of HFLC% as a diagnostic tool and its association with serological status in diagnosed dengue patients and thereby establish a cutoff of HFLC% based on serology. Besides, we also wish to correlate HFLC% with thrombocytopenia in these patients. MATERIALS AND METHODS: A total of 1500 serum samples were subjected to serological evaluation for dengue. After excluding hematological malignancies and autoimmune disorders, the same day complete blood count parameters including HFLC% and platelet counts were collected retrospectively for 292 serologically positive dengue cases and 76 seronegative controls. RESULTS: Our result shows that in nonstructural 1 antigen-positive cases, a cutoff of >5.2% HFLC can have a sensitivity of 79.5% and specificity of 98.6%. We found a different cut off of HFLC% >3.2% (sensitivity 83.4%, specificity 98.6%) for the cases with only immunoglobulin M positivity and a cut off of HFLC% >2.6% (sensitivity 86.1%, specificity 96%) in the dual positive cases (immunoglobulin M with nonstructural 1 antigen). Besides, high HFLC% also shows a strong correlation with platelet count with a Spearman correlation coefficient of −0.6. CONCLUSIONS: The result of our study shows that a specific cutoff of HFLC% can not only help us to suspect dengue fever but also predict the risk of thrombocytopenia in already diagnosed dengue patients. The sensitivity and specificity of HFLC% varied with the serological status of the patients which depend on the days of fever on presentation. [ABSTRACT FROM AUTHOR]

Published
2022
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36. Detection of SARS-CoV2 virus using the real-time reverse transcriptase polymerase chain reaction in semen and seminal plasma from men with active COVID-19 infection -- A pilot study.

Author

Gupta, Pankush, Choudhary, Aashish, Gopal, Giridara, Kumar, Rajeev, Kumar, Arbind, Tiwari, Pawan, and Malhotra, Neena

Subjects
REVERSE transcriptase polymerase chain reaction, COVID-19, SARS-CoV-2, SEMEN, CROSS-sectional method, SEMEN analysis, DESCRIPTIVE statistics, COVID-19 testing, POLYMERASE chain reaction, COLLECTION & preservation of biological specimens
Abstract

Introduction: SARS CoV 2 has been detected in various body fluids. Its presence in semen has been tested with contradictory results. This study aimed to detect the presence of SARS-CoV-2 virus using the real-time reverse transcriptase-polymerase chain reaction (rRT-PCR) in semen and seminal plasma from men with active COVID-19 infection. Methods: In a cross-sectional study at a COVID facility, men aged 20-45 years with active COVID-19 infection provided semen samples within 7 days of symptom onset or 5 days of nasopharyngeal rRT-PCR test positivity in asymptomatic men. Testing of SARS-CoV-2 was performed using rRT-PCR and semen analysis was done for sperm counts and motility as per the WHO (2010) standards. Results: A total of 37 men with a mean age of 32.2 ± 5.6 years were tested. SARS CoV-2 virus could not be isolated in any of the samples. Further, microscopic analysis done on 17 samples showed normal semen parameters during the active phase of disease. Conclusion: Men with mild COVID-19 disease or asymptomatic individuals do not shed virus in their semen, ruling out sexual contact as a mode of transmission in this subset of population. [ABSTRACT FROM AUTHOR]

Published
2021
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37. Clinico-demographic profile & hospital outcomes of COVID-19 patients admitted at a tertiary care centre in north India

Author

Mohan, Anant, primary, Tiwari, Pawan, additional, Bhatnagar, Sushma, additional, Patel, Ankit, additional, Maurya, Abhishek, additional, Dar, Lalit, additional, Pahuja, Sourabh, additional, Garg, Rakesh, additional, Gupta, Nishkarsh, additional, Sahoo, Biswajeet, additional, Gupta, Ritu, additional, Meena, VedPrakash, additional, Vig, Saurabh, additional, Pandit, Anuja, additional, Mittal, Saurabh, additional, Madan, Karan, additional, Hadda, Vijay, additional, Dwivedi, Tanima, additional, Choudhary, Aashish, additional, Brijwal, Megha, additional, Soneja, Manish, additional, Guleria, Randeep, additional, Ratre, Brajesh, additional, Kumar, Balbir, additional, Bhopale, Shweta, additional, Panda, Smriti, additional, Singh, AngelRajan, additional, Singh, Sheetal, additional, and Wundavalli, Laxmitej, additional

Published
2020
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38. Authors' response

Author

Abraham, Priya, primary, Gupta, Nivedita, additional, Potdar, Varsha, additional, Praharaj, Ira, additional, Giri, Sidhartha, additional, Sapkal, Gajanan, additional, Yadav, Pragya, additional, Choudhary, ManoharLal, additional, Dar, Lalit, additional, Sugunan, AP, additional, Kaur, Harmanmeet, additional, Munivenkatappa, Ashok, additional, Shastri, Jayanthi, additional, Kaveri, Krishnasamy, additional, Dutta, Shanta, additional, Malhotra, Bharti, additional, Jain, Amita, additional, Nagamani, Kammilli, additional, Shantala, GB, additional, Raut, Sharmila, additional, Vegad, MM, additional, Sharma, Ajanta, additional, Choudhary, Aashish, additional, Brijwa, Megha, additional, Balakrishnan, Anukumar, additional, Manjunatha, Jayaswamy, additional, Pathak, Manish, additional, Srinivasan, Sivasubramanian, additional, Banu, Hasina, additional, Sharma, Himanshu, additional, Jain, Parul, additional, Sunita, Pakalpati, additional, Ambica, R, additional, Fageria, Babita, additional, Patel, Disha, additional, Rajbongshi, Gitika, additional, Vijay, Neetu, additional, Narayan, Jitendra, additional, Aggarwal, Neeraj, additional, Nagar, Anu, additional, and Gangakhedkar, RamanR, additional

Published
2020
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39. Laboratory preparedness for SARS-CoV-2 testing in India: Harnessing a network of Virus Research & Diagnostic Laboratories

Author

Abraham, Priya, primary, Gupta, Nivedita, additional, Potdar, Varsha, additional, Praharaj, Ira, additional, Giri, Sidhartha, additional, Sapkal, Gajanan, additional, Yadav, Pragya, additional, Choudhary, ManoharLal, additional, Dar, Lalit, additional, Sugunan, AP, additional, Kaur, Harmanmeet, additional, Munivenkatappa, Ashok, additional, Shastri, Jayanthi, additional, Kaveri, Krishnasamy, additional, Dutta, Shanta, additional, Malhotra, Bharti, additional, Jain, Amita, additional, Nagamani, Kammilli, additional, Shantala, GB, additional, Raut, Sharmila, additional, Vegad, MM, additional, Sharma, Ajanta, additional, Choudhary, Aashish, additional, Brijwal, Megha, additional, Balakrishnan, Anukumar, additional, Manjunatha, Jayaswamy, additional, Pathak, Manish, additional, Srinivasan, Sivasubramanian, additional, Banu, Hasina, additional, Sharma, Himanshu, additional, Jain, Parul, additional, Sunita, Pakalpati, additional, Ambica, R, additional, Fageria, Babita, additional, Patel, Disha, additional, Rajbongshi, Gitika, additional, Vijay, Neetu, additional, Narayan, Jitendra, additional, Aggarwal, Neeraj, additional, Nagar, Anu, additional, and Gangakhedkar, RamanR, additional

Published
2020
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40. A cluster of SARS-CoV-2 infection among Italian tourists visiting India, March 2020

Author

Murhekar, Manoj, primary, Vivian Thangaraj, JeromieWesley, additional, Mehta, Yatin, additional, Kataria, Sushila, additional, Brijwal, Megha, additional, Gupta, Nitesh, additional, Choudhary, Aashish, additional, Malhotra, Bharati, additional, Vyas, Madhavi, additional, Sharma, Himanshu, additional, Yadav, Naveen, additional, Bhatnagar, Tarun, additional, Gupta, Nivedita, additional, Dar, Lalit, additional, Gangakhedkar, RamanR, additional, and Bhargava, Balram, additional

Published
2020
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