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23 results on '"Chou, Stephanie"'

1. An induced pluripotent stem cell model of Fanconi anemia reveals mechanisms of p53-driven progenitor cell differentiation

Author

Marion, William, Boettcher, Steffen, Ruiz-Torres, Sonya, Lummertz da Rocha, Edroaldo, Lundin, Vanessa, Morris, Vivian, Chou, Stephanie, Zhao, Anna M., Kubaczka, Caroline, Aumais, Olivia, Zhang, Yosra, Shimamura, Akiko, Schlaeger, Thorsten M., North, Trista E., Ebert, Benjamin L., Wells, Susanne I., Daley, George Q., and Rowe, R. Grant

Published
2020
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2. Flow-induced protein kinase A–CREB pathway acts via BMP signaling to promote HSC emergence

Author

Kim, Peter Geon, Nakano, Haruko, Das, Partha P, Chen, Michael J, Rowe, R Grant, Chou, Stephanie S, Ross, Samantha J, Sakamoto, Kathleen M, Zon, Leonard I, Schlaeger, Thorsten M, Orkin, Stuart H, Nakano, Atsushi, and Daley, George Q

Subjects
Biomedical and Clinical Sciences, Biotechnology, Stem Cell Research - Nonembryonic - Non-Human, Stem Cell Research, Hematology, Underpinning research, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Aetiology, Animals, Bone Morphogenetic Proteins, Cyclic AMP Response Element-Binding Protein, Cyclic AMP-Dependent Protein Kinases, Embryo, Mammalian, Endothelial Cells, Hematopoietic Stem Cells, Mesonephros, Mice, Mice, Mutant Strains, Signal Transduction, Sodium-Calcium Exchanger, Medical and Health Sciences, Immunology, Biomedical and clinical sciences, Health sciences
Abstract

Fluid shear stress promotes the emergence of hematopoietic stem cells (HSCs) in the aorta-gonad-mesonephros (AGM) of the developing mouse embryo. We determined that the AGM is enriched for expression of targets of protein kinase A (PKA)-cAMP response element-binding protein (CREB), a pathway activated by fluid shear stress. By analyzing CREB genomic occupancy from chromatin-immunoprecipitation sequencing (ChIP-seq) data, we identified the bone morphogenetic protein (BMP) pathway as a potential regulator of CREB. By chemical modulation of the PKA-CREB and BMP pathways in isolated AGM VE-cadherin(+) cells from mid-gestation embryos, we demonstrate that PKA-CREB regulates hematopoietic engraftment and clonogenicity of hematopoietic progenitors, and is dependent on secreted BMP ligands through the type I BMP receptor. Finally, we observed blunting of this signaling axis using Ncx1-null embryos, which lack a heartbeat and intravascular flow. Collectively, we have identified a novel PKA-CREB-BMP signaling pathway downstream of shear stress that regulates HSC emergence in the AGM via the endothelial-to-hematopoietic transition.

Published
2015

3. Total posterior leg open wound management with free anterolateral thigh flap: case and literature review.

Author

Osman, Soleiman, Chou, Stephanie, Rosing, James, and Sahar, David E

Subjects
Achilles tendon, anterolateral thigh flap, free tissue transfer, microsurgery, surgical flap, Clinical Sciences
Abstract

Soft tissue coverage of the exposed Achilles tendon is a unique reconstructive challenge. In this report, we describe the management of a large posterior leg wound with exposed Achilles tendon using a free anterolateral thigh (ALT) flap. A careful review of alternative reconstructive options is included, along with their respective advantages and disadvantages. A 32-year-old white man suffered a fulminant right lower extremity soft tissue infection requiring extensive debridement of the entire posterior surface of the right leg. The resulting large soft tissue defect included exposure of the Achilles tendon. Reconstruction of the defect was achieved with an ALT flap and split-thickness skin graft for coverage of the Achilles tendon and gastrocnemius muscle, respectively. The patient was able to ambulate independently within 2 months of the procedure.

Published
2013

7. Author response: Label-free three-photon imaging of intact human cerebral organoids for tracking early events in brain development and deficits in Rett syndrome

Author

Yildirim, Murat, primary, Delepine, Chloe, additional, Feldman, Danielle, additional, Pham, Vincent A, additional, Chou, Stephanie, additional, Ip, Jacque, additional, Nott, Alexi, additional, Tsai, Li-Huei, additional, Ming, Guo-Li, additional, So, Peter TC, additional, and Sur, Mriganka, additional

Published
2022
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8. Failure to replicate the STAP cell phenomenon

Author

De Los Angeles, Alejandro, Ferrari, Francesco, Fujiwara, Yuko, Mathieu, Ronald, Lee, Soohyun, Lee, Semin, Tu, Ho-Chou, Ross, Samantha, Chou, Stephanie, Nguyen, Minh, Wu, Zhaoting, Theunissen, Thorold W., Powell, Benjamin E., Imsoonthornruksa, Sumeth, Chen, Jiekai, Borkent, Marti, Krupalnik, Vladislav, Lujan, Ernesto, Wernig, Marius, Hanna, Jacob H., Hochedlinger, Konrad, Pei, Duanqing, Jaenisch, Rudolf, Deng, Hongkui, Orkin, Stuart H., Park, Peter J., and Daley, George Q.

Subjects
Cytological research, Stem cells -- Physiological aspects, Medical protocols -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Alejandro De Los Angeles [1, 2, 3]; Francesco Ferrari [4]; Yuko Fujiwara [1, 2, 3]; Ronald Mathieu [5]; Soohyun Lee [4]; Semin Lee [4]; Ho-Chou Tu [1, 2, 3]; [...]

Published
2015
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9. Label-free three-photon imaging of intact human cerebral organoids: tracking early events in brain development and deficits in Rett Syndrome

Author

Yildirim, Murat, primary, Delepine, Chloe, additional, Feldman, Danielle, additional, Pham, Vincent, additional, Chou, Stephanie, additional, Kan Ip, Jacque Pak, additional, Nott, Alexi, additional, Tsai, Li-Huei, additional, Ming, Guo-li, additional, So, Peter T. C., additional, and Sur, Mriganka, additional

Published
2022
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10. 3097 – RNA EDITOR-EXONUCLEASE AXIS SCULPTS THE TRANSCRIPTOME DURING TERMINAL ERYTHROID DIFFERENTIATION

Author

Han, Areum, primary, Han, areum, additional, Yermalovich, Alena, additional, Lundin, Vanessa, additional, Pearson, Daniel, additional, Hilton, Brianna, additional, Markel, Arianna, additional, Sousa, Patricia, additional, Morse, Michael, additional, Zhang, Yosra, additional, Derafshi, Bahareh, additional, Chou, Stephanie, additional, Atwater, John, additional, Tang, Yang, additional, Frame, Jenna, additional, Hachimi, Mariam, additional, Kubaczka, Caroline, additional, Hunter, Phoebe, additional, Huang, Yu, additional, Morris, Vivian, additional, Jing, Ran, additional, Osborne, Jihan, additional, North, Trista, additional, Schlaeger, Thorsten, additional, and Daley, George, additional

Published
2022
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11. 3039 – YAP REGULATES HEMATOPOIETIC STEM CELL FORMATION IN RESPONSE TO THE BIOMECHANICAL FORCES OF BLOOD FLOW

Author

Sugden, Wade, primary, Lundin, Vanessa, additional, Theodore, Lindsay, additional, Sousa, Patricia, additional, Han, Areum, additional, Chou, Stephanie, additional, Wrighton, Paul, additional, Cox, Andrew, additional, Ingber, Donald, additional, Goessling, Wolfram, additional, Daley, George, additional, and North, Trista, additional

Published
2020
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12. YAP Regulates Hematopoietic Stem Cell Formation in Response to the Biomechanical Forces of Blood Flow

Author

Lundin, Vanessa, primary, Sugden, Wade W., additional, Theodore, Lindsay N., additional, Sousa, Patricia M., additional, Han, Areum, additional, Chou, Stephanie, additional, Wrighton, Paul J., additional, Cox, Andrew G., additional, Ingber, Donald E., additional, Goessling, Wolfram, additional, Daley, George Q., additional, and North, Trista E., additional

Published
2020
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14. Erratum: Corrigendum: Failure to replicate the STAP cell phenomenon

Author

De Los Angeles, Alejandro, primary, Ferrari, Francesco, additional, Fujiwara, Yuko, additional, Mathieu, Ronald, additional, Lee, Soohyun, additional, Lee, Semin, additional, Tu, Ho-Chou, additional, Ross, Samantha, additional, Chou, Stephanie, additional, Nguyen, Minh, additional, Wu, Zhaoting, additional, Theunissen, Thorold W., additional, Powell, Benjamin E., additional, Imsoonthornruksa, Sumeth, additional, Chen, Jiekai, additional, Borkent, Marti, additional, Krupalnik, Vladislav, additional, Lujan, Ernesto, additional, Wernig, Marius, additional, Hanna, Jacob H., additional, Hochedlinger, Konrad, additional, Pei, Duanqing, additional, Jaenisch, Rudolf, additional, Deng, Hongkui, additional, Orkin, Stuart H., additional, Park, Peter J., additional, and Daley, George Q., additional

Published
2015
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15. Flow-induced protein kinase A–CREB pathway acts via BMP signaling to promote HSC emergence

Author

Kim, Peter Geon, primary, Nakano, Haruko, additional, Das, Partha P., additional, Chen, Michael J., additional, Rowe, R. Grant, additional, Chou, Stephanie S., additional, Ross, Samantha J., additional, Sakamoto, Kathleen M., additional, Zon, Leonard I., additional, Schlaeger, Thorsten M., additional, Orkin, Stuart H., additional, Nakano, Atsushi, additional, and Daley, George Q., additional

Published
2015
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20. Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells via Respecification of Lineage-Restricted Precursors

Author

Doulatov, Sergei, primary, Vo, Linda T., additional, Chou, Stephanie S., additional, Kim, Peter G., additional, Arora, Natasha, additional, Li, Hu, additional, Hadland, Brandon K., additional, Bernstein, Irwin D., additional, Collins, James J., additional, Zon, Leonard I., additional, and Daley, George Q., additional

Published
2013
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22. Corrigendum: Failure to replicate the STAP cell phenomenon.

Author

De Los Angeles, Alejandro, Ferrari, Francesco, Fujiwara, Yuko, Mathieu, Ronald, Lee, Soohyun, Lee, Semin, Tu, Ho-Chou, Ross, Samantha, Chou, Stephanie, Nguyen, Minh, Wu, Zhaoting, Theunissen, Thorold W., Powell, Benjamin E., Imsoonthornruksa, Sumeth, Chen, Jiekai, Borkent, Marti, Krupalnik, Vladislav, Lujan, Ernesto, Wernig, Marius, and Hanna, Jacob H.

Published
2016
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23. Total posterior leg open wound management with free anterolateral thigh flap: case and literature review.

Author

Osman S, Chou S, Rosing J, and Sahar DE

Abstract

Soft tissue coverage of the exposed Achilles tendon is a unique reconstructive challenge. In this report, we describe the management of a large posterior leg wound with exposed Achilles tendon using a free anterolateral thigh (ALT) flap. A careful review of alternative reconstructive options is included, along with their respective advantages and disadvantages. A 32-year-old white man suffered a fulminant right lower extremity soft tissue infection requiring extensive debridement of the entire posterior surface of the right leg. The resulting large soft tissue defect included exposure of the Achilles tendon. Reconstruction of the defect was achieved with an ALT flap and split-thickness skin graft for coverage of the Achilles tendon and gastrocnemius muscle, respectively. The patient was able to ambulate independently within 2 months of the procedure.

Published
2013

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