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163 results on '"Choong, Hui-Lin"'

7. Impact of focal segmental glomerulosclerosis over the past decade

Author

Woo, Keng Thye, primary, Chan, Choong Meng, additional, Foo, Marjorie, additional, Lim, Cynthia, additional, Choo, Jason, additional, Chin, Yok Mooi, additional, Teng, Esther Wei Ling, additional, Mok, Irene, additional, Kwek, Jia Liang, additional, Tan, Hui Zhuan, additional, Loh, Alwin H.L., additional, Wong, Jiunn, additional, Kee, Terence, additional, Choong, Hui Lin, additional, Tan, Han Khim, additional, Wong, Kok Seng, additional, Tan, Puay Hoon, additional, and Tan, Chieh Suai, additional

Published
2023
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10. Regional citrate anticoagulation vs systemic heparin anticoagulation for double‐filtration plasmapheresis

Author

Teh, Swee Ping, primary, Ho, Quan Yao, additional, Kee, Yi Shern Terence, additional, Thangaraju, Sobhana, additional, Tan, Ru Yu, additional, Teo, Su Hooi, additional, Tan, Han Khim, additional, Tan, Chieh Suai, additional, Choong, Hui Lin Lina, additional, Ng, Li Choo, additional, Abdul Rahman, Maslinna, additional, Lim, Amy Ee Lin, additional, and Kaushik, Manish, additional

Published
2022
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18. Regional citrate anticoagulation vs systemic heparin anticoagulation for double‐filtration plasmapheresis.

Author

Teh, Swee Ping, Ho, Quan Yao, Kee, Yi Shern Terence, Thangaraju, Sobhana, Tan, Ru Yu, Teo, Su Hooi, Tan, Han Khim, Tan, Chieh Suai, Choong, Hui Lin Lina, Ng, Li Choo, Abdul Rahman, Maslinna, Lim, Amy Ee Lin, and Kaushik, Manish

Subjects
HEPARIN, PLASMAPHERESIS, VASCULAR catheters, ANTICOAGULANTS, CITRATES
Abstract

Introduction: Double‐filtration plasmapheresis (DFPP) has been utilized for immunomodulation in kidney transplantation. Anticoagulation is important to maintain circuit patency during DFPP. We aimed to compare the efficacy and safety of regional citrate anticoagulation (RCA) with systemic heparin anticoagulation during DFPP in kidney transplant recipients. Methods: A retrospective cohort study was conducted to compare the efficacy and safety of RCA (RCA‐DFPP) to systemic heparin anticoagulation (Hep‐DFPP) for DFPP among kidney transplant recipients in a single tertiary center. Results: A total of 112 sessions of DFPP were performed for 23 subjects, of which 62 sessions were RCA‐DFPP and 50 sessions were Hep‐DFPP. There were 13 sessions (11.6%) of premature circuit clotting, 10 sessions (16.1%) for RCA‐DFPP and 3 sessions (6.0%) for Hep‐DFPP (P =.10). All premature circuit clotting episodes occurred in subjects who underwent DFPP through a vascular catheter. Premature circuit clotting was associated with the use of a vascular catheter (odds ratio [OR] 14.2, 95% confidence interval [CI] 2.7‐73.7; P <.01) and high postfilter ionized calcium (OR 12.7, 95% CI 1.4‐112.5; P <.01). There was no major bleeding event. Hep‐DFPP was associated with higher occurrence of hypocalcemia (OR 1.1, 95% CI 1.0‐1.2; P <.01) and metabolic acidosis (OR 1.4, 95% CI 1.2‐2.0; P =.04), while hypomagnesemia was more common for RCA‐DFPP (OR 2.9, 95% CI 1.1‐7.4; P =.03). Conclusion: Amongst kidney transplant patients who receive DFPP therapy, RCA‐DFPP may be comparable to Hep‐DFPP for the maintenance of circuit patency. Functioning vascular access is vital in avoiding premature clotting of the circuit. Close monitoring of electrolyte imbalances and coagulopathy related to DFPP is recommended. [ABSTRACT FROM AUTHOR]

Published
2023
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20. Evolution of IgA nephropathy in Singapore over four decades and a comparison of two cohorts from the first and fourth decade

Author

Woo, Keng Thye, primary, Chan, Choong Meng, additional, Foo, Marjorie, additional, Lim, Cynthia, additional, Choo, Jason, additional, Chin, Yok Mooi, additional, Teng, Esther Wei Ling, additional, Yusoff, Permeen A. Mohamed, additional, Mok, Irene, additional, Kwek, Jia Liang, additional, Tan, Hui Zhuan, additional, Loh, Alwin H.L., additional, Choong, Hui Lin, additional, Tan, Han Khim, additional, Wong, Kok Seng, additional, Lee, Grace S.L., additional, Lee, Evan, additional, Tan, Puay Hoon, additional, and Tan, Chieh Suai, additional

Published
2021
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21. Validation of the kidney failure risk equation in predicting the risk of progression to kidney failure in a multi-ethnic Singapore chronic kidney disease cohort.

Author

Jia Liang Kwek, Hui Qing Jolyn Pang, Huihua Li, Wei Wei Lydia Lim, Jason Chon Jun Choo, Hui Lin Choong, Marjorie Wai Yin Foo, Choong Meng Chan, Kwek, Jia Liang, Pang, Hui Qing Jolyn, Li, Huihua, Lim, Wei Wei Lydia, Choo, Jason Chon Jun, Choong, Hui Lin, Foo, Marjorie Wai Yin, and Chan, Choong Meng

Subjects
KIDNEY failure, CHRONIC kidney failure, SOUTHEAST Asians, GLOMERULAR filtration rate, SERUM albumin
Abstract

Introduction: The Kidney Failure Risk Equation (KFRE) was developed to predict the risk of progression to end-stage kidney disease (ESKD). Although the KFRE has been validated in multinational cohorts, the Southeast Asian population was under-represented. This study aimed to validate the KFRE in a multi-ethnic Singapore chronic kidney disease (CKD) cohort.Methods: Stage 3-5 CKD patients referred to the renal medicine department at Singapore General Hospital in 2009 were included. The primary outcome (time to ESKD) was traced until 30 June 2017. The eight- and four-variable KFRE (non-North America) models using age, gender, estimated glomerular filtration rate, urine albumin-creatinine ratio, serum albumin, phosphate, bicarbonate and calcium were validated in our cohort. Cox regression, likelihood ratio (χ2), adequacy index, Harrell's C-index and calibration curves were calculated to assess the predictive performance, discrimination and calibration of these models on the cohort.Results: A total of 1,128 patients were included. During the study period, 252 (22.3%) patients reached ESKD at a median time to ESKD of 84.8 (range 0.1-104.7) months. Both the eight- and four-variable KFRE models showed excellent predictive performance and discrimination (eight-variable: C-index 0.872, 95% confidence interval [CI] 0.850-0.894, adequacy index 97.3%; four-variable: C-index 0.874, 95% CI 0.852-0.896, adequacy index 97.9%). There was no incremental improvement in the prediction ability of the eight-variable model over the four-variable model in this cohort.Conclusion: The KFRE was validated in a multi-ethnic Singapore CKD cohort. This risk score may help to identify patients requiring early renal care. [ABSTRACT FROM AUTHOR]

Published
2022
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22. Understanding factors that influence the demand for dialysis among elderly in a multi-ethnic Asian society

Author

Lina Choong Hui Lin, Eric A. Finkelstein, Semra Ozdemir, Sheryl Gan Shien Wen, Tazeen H. Jafar, and Chetna Malhotra

Subjects
Male, medicine.medical_specialty, Conservative management, medicine.medical_treatment, 030232 urology & nephrology, Ethnic group, Discrete choice experiment, Comorbidity, Choice Behavior, End stage renal disease, 03 medical and health sciences, 0302 clinical medicine, Asian People, Renal Dialysis, Surveys and Questionnaires, Ethnicity, Humans, Medicine, Lack of knowledge, 030212 general & internal medicine, Dialysis, Aged, Singapore, business.industry, Family caregivers, Health Policy, Patient Preference, Middle Aged, Confidence interval, Caregivers, Emergency medicine, Kidney Failure, Chronic, Female, business
Abstract

Background Despite literature suggesting conservative management (CM) is a viable option for elderly comorbid ESRD patients, the vast majority in Singapore receive dialysis. We hypothesized that the high demand for dialysis is driven by 1) lack of knowledge of CM and relative benefits of dialysis to CM, 2) adherence to physician recommendations which favour dialysis, and 3) high subsidies for haemodialysis (HD). Methods We tested these hypotheses via a survey, including a discrete choice experiment (DCE), administered to 151 elderly pre-dialysis kidney patients and their family caregivers. Results Results are consistent with the hypotheses: 40% (95% Confidence Interval (CI) 32–48) of patients and 46% (CI 38–55) of caregivers reported not being aware of CM, and 43% (CI 35–51) of patients and 24% (CI 17–31) of caregivers could not provide information on expected survival for dialysis or CM. Yet, once aware of CM as an option, 54% of patients and 42% of caregivers chose CM. However, if their physician recommended dialysis, 49% (CI 40–58) of patients and 68% (CI 59–77) of caregivers switched their choice. Subsidies on HD further reduced demand for CM by 6 percentage points. Conclusions These results reveal that the high demand for dialysis is driven mostly by lack of awareness of CM as an option and by physician recommendations for dialysis over CM.

Published
2018

23. Increasing home based dialysis therapies to tackle dialysis burden around the world: A position statement on dialysis economics from the 2nd Congress of the International Society for Hemodialysis

Author

LI, PHILIP KAM-TAO, CHEUNG, WAI LUN, LUI, SING LEUNG, BLAGG, CHRISTOPHER, CASS, ALAN, HOOI, LAI SEONG, LEE, HO YUNG, LOCATELLI, FRANCESCO, WANG, TAO, YANG, CHIH-WEI, CANAUD, BERNARD, CHENG, YUK LUN, CHOONG, HUI LIN, DE FRANCISCO, ANGEL L, GURA, VICTOR, KAIZU, KAZO, KERR, PETER G, KUOK, UN I, LEUNG, CHI BON, LO, WAI-KEI, MISRA, MADHUKAR, SZETO, CHEUK CHUN, TONG, KWOK LUNG, TUNGSANGA, KRIANG, WALKER, ROBERT, WONG, ANDREW KUI-MAN, and YU, ALEX WAI-YIN

Published
2011
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24. The Value of Renal Biopsy in Non-Insulin-Dependent Diabetes Mellitus in Singapore over the Past Two Decades

Author

Woo, Keng Thye, primary, Chan, Choong Meng, additional, Lim, Cynthia, additional, Choo, Jason, additional, Chin, Yoke Mooi, additional, Teng, Esther Wei Ling, additional, Mok, Irene, additional, Kwek, Jia Liang, additional, Tan, Chieh Suai, additional, Tan, Hui Zhuan, additional, Loh, Alwin H.L., additional, Choong, Hui Lin, additional, Tan, Han Kim, additional, Lee, Grace S.L., additional, Lee, Evan, additional, Wong, Kok Seng, additional, Tan, Puay Hoon, additional, and Foo, Marjorie, additional

Published
2020
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28. Additional file 2: of Biopsychosocial experiences and coping strategies of elderly ESRD patients: a qualitative study to inform the development of more holistic and person-centred health services in Singapore

Author

Han, Emeline, Shiraz, Farah, Haldane, Victoria, Koh, Joel, Quek, Rina, Ozdemir, Semra, Finkelstein, Eric, Tazeen Jafar, Choong, Hui-Lin, Gan, Sheryl, Lim, Lydia, and Legido-Quigley, Helena

Abstract

Consolidated criteria for reporting qualitative studies (COREQ): 32-item checklist. (DOCX 20 kb)

Published
2019
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29. Additional file 3: of Biopsychosocial experiences and coping strategies of elderly ESRD patients: a qualitative study to inform the development of more holistic and person-centred health services in Singapore

Author

Han, Emeline, Shiraz, Farah, Haldane, Victoria, Koh, Joel, Quek, Rina, Ozdemir, Semra, Finkelstein, Eric, Tazeen Jafar, Choong, Hui-Lin, Gan, Sheryl, Lim, Lydia, and Legido-Quigley, Helena

Abstract

Table of key themes, subthemes and verbatim extracts examining the biopsychosocial impact of ESRD and coping mechanisms of elderly ESRD patients and caregivers (n =â 23). (DOCX 22 kb)

Published
2019
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32. Perspectives on decision making amongst older people with end‐stage renal disease and caregivers in Singapore: A qualitative study

Author

Han, Emeline, primary, Haldane, Victoria, additional, Koh, Joel Jun Kai, additional, Quek, Rina Yu Chin, additional, Ozdemir, Semra, additional, Finkelstein, Eric Andrew, additional, Jafar, Tazeen Hasan, additional, Choong, Hui‐Lin, additional, Gan, Sheryl, additional, Lim, Lydia W. W., additional, Shiraz, Farah, additional, and Legido‐Quigley, Helena, additional

Published
2019
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33. Validation of the failure to maturation equation and proposal for a novel scoring system for arteriovenous fistula maturation in multiethnic Asian haemodialysis patients

Author

Tng, Alvin Ren Kwang, primary, Lee, Kian Guan, additional, Tan, Ru Yu, additional, Pang, Suh Chien, additional, Foo, Marjorie Wai Yin, additional, Choong, Hui Lin, additional, Li, Hui Hua, additional, Goh, Nicholette, additional, Shaam, Achudan, additional, Tan, Yi Liang, additional, Chong, Tze Tec, additional, and Tan, Chieh Suai, additional

Published
2019
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36. Changes in primary glomerulonephritis in Singapore over four decades

Author

Woo, Keng-Thye, primary, Chan, Choong-Meng, additional, Lim, Cynthia, additional, Choo, Jason, additional, Chin, Yoke Mooi, additional, Teng, Wei Ling, additional, Loh, Alwin H.L., additional, Choong, Hui-Lin, additional, Tan, Han-Kim, additional, Wong, Kok-Seng, additional, Lee, Grace S.L., additional, Lee, Evan J.C., additional, Fook-Chong, Stephanie, additional, Tan, Puay Hoon, additional, and Foo, Marjorie, additional

Published
2019
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37. A Global Evolutionary Trend of the Frequency of Primary Glomerulonephritis over the Past Four Decades

Author

Woo, Keng Thye, primary, Chan, Choong Meng, additional, Lim, Cynthia, additional, Choo, Jason, additional, Chin, Yok Mooi, additional, Teng, Esther Wei Ling, additional, Mok, Irene, additional, Kwek, Jia Liang, additional, Loh, Alwin H.L., additional, Choong, Hui Lin, additional, Tan, Han Kim, additional, Lee, Grace S.L., additional, Lee, Evan, additional, Wong, Kok Seng, additional, Tan, Puay Hoon, additional, and Foo, Marjorie, additional

Published
2019
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39. Hemodialysis Arteriovenous Fistula and Graft Stenoses: Randomized Trial Comparing Drug-eluting Balloon Angioplasty with Conventional Angioplasty

Author

Irani, Farah Gillan, primary, Teo, Terence Kiat Beng, additional, Tay, Kiang Hiong, additional, Yin, Win Htet, additional, Win, Hlaing Hlaing, additional, Gogna, Apoorva, additional, Patel, Ankur, additional, Too, Chow Wei, additional, Chan, Shaun Xavier Ju Min, additional, Lo, Richard Hoau Gong, additional, Toh, Luke Han Wei, additional, Chng, Siew Ping, additional, Choong, Hui Lin, additional, and Tan, Bien Soo, additional

Published
2018
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40. SP220LONG TERM OUTCOME AND MORTALITY OF A PROSPECTIVE STUDY OF PATIENTS WITH ACUTE KIDNEY INJURY FROM A TERTIARY CENTRE IN SINGAPORE

Author

Teo, Su Hooi, primary, Lee, Kian-Guan, additional, Koniman, Riece, additional, Tng, Alvin Ren Kwang, additional, Liew, Zhong Hong, additional, Naing, Thin Thiri, additional, Li, Huihua, additional, Tan, Han Khim, additional, Choong, Hui Lin, additional, Foo, W Y Marjorie, additional, and Kaushik, Manish, additional

Published
2018
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47. A retrospective Aliskiren and Losartan study in non-diabetic chronic kidney disease

Author

Woo, Keng-Thye, Choong, Hui-Lin, Wong, Kok-Seng, Tan, Han-Kim, Foo, Marjorie, Stephanie, Fook-Chong, Lee, Evan JC, Anantharaman, Vathsala, Lee, Grace SL, and Chan, Choong-Meng

Subjects
Brief Article, cardiovascular system, hormones, hormone substitutes, and hormone antagonists, circulatory and respiratory physiology
Abstract

To assess the efficacy of combined Aliskiren and Losartan vs high dose Losartan and Aliskiren alone in chronic kidney disease (CKD).This is a retrospective study of 143 patients with non-diabetic CKD comparing combined Aliskiren (150 mg/d) with Losartan (100 mg/d) therapy vs High dose Angiotensin receptor blockers (ARB) (Losartan 200 mg/d) and the third group Aliskiren (150 mg/d) alone. This study involved only patient medical records. Entry criteria included those patients who had been treated with the above drugs for at least 36 mo within the 5 years period; other criteria included proteinuria of 1 g or more and or CKD Stage 3 at the start of the 36 mo period. The study utilised primary renal end points of estimated Glomerular Filtration Rate (eGFR)15 mL/min or end stage renal failure.Patients treated with high dose ARB compared to the other two treatment groups had significantly less proteinuria at the end of 36 mo (P0.007). All 3 groups had significant reduction of proteinuria (P0.043, P0.001). Total urinary protein was significantly different between the 3 groups over the 3-year study period (P = 0.008), but not eGFR. The changes in eGFR from baseline to each year were not significantly different between the 3 therapeutic groups (P0.119). There were no significant differences in the systolic and diastolic blood pressure between the 3 drug groups throughout the 3 years. The incidence of hyperkalemia (5.5 mmol/L) was 14.2% (7/49) in the Combined Aliskiren and ARB group, 8.7% (4/46) in the Aliskiren alone group and 6.3% (3/48) in the High dose ARB group (P0.001).This study in non-diabetic CKD patients showed that Combination therapy with Aliskiren and ARB was effective but was not safe as it was associated with a high prevalence of hyperkalaemia.

Published
2013

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