Search

A severe paraneoplastic form of acute encephalitis associated with antibodies against the N-methyl D-aspartate (NMDA) receptor typically occurs in young individuals and is associated, but not always, with an underlying tumor. If diagnosed early, initiation of immunotherapy and tumor removal (if present) may result in recovery. We report a case in a 25-year-old young woman who presented to our medical center with postpartum psychosis. Treatment with rituximab (a chimeric monoclonal antibody against the protein CD20) resulted in gradual improvement in mental status and resolution of seizure activity episodes. A year after diagnosis and treatment, the patient was doing well without recurrences, and no tumors appeared. This is the first described case of anti-NMDA-receptor antibodies encephalitis that presented initially as a postpartum psychosis disorder and was successfully treated with rituximab.

Kodamaea (Pichia) ohmeri is an unusual yeast-form fungus that has recently been identified as an important etiology of fungemia, endocarditis, cellulitis, funguria and peritonitis in immunocompromised patients. We report a case of K. ohmeri fungemia in a 34-year-old hospitalized patient with thrombophlebitis. The patient was admitted to the hospital for evaluation and management of an acquired tracheo-esophageal fistula secondary to an impacted denture. Fever developed on hospital day 22, and physical exam revealed right arm superficial thrombophlebitis at the site of the peripheral venous catheter that was confirmed by Doppler ultrasound. The peripheral vein was removed and blood cultures from hospital day 22 and 23 grew yeast species. The yeast was subsequently identified to be K. ohmeri by Vitek II and API20C and was confirmed by 18S rRNA gene sequencing. The fungemia and right arm phlebitis was successfully treated with a 2-week course of micafungin therapy. This is the first case of K. ohmeri fungemia in a patient that was successfully treated with micafungin.

Sclerotic and lytic bone changes of tuberous sclerosis (TS) can mimic bone metastases. We report a case of bone metastases from bronchogenic carcinoma in a patient with TS bone changes. Bone scintigraphy and magnetic resonance imaging are useful in distinguishing the TS bone lesions from bone metastases.

Duplex ultrasonography is a safe, accurate, efficient, inexpensive, noninvasive diagnostic test for deep vein thrombosis (DVT). The sensitivity and specificity of this technique is comparable to venography in symptomatic patients in many studies. The diagnostic accuracy of this test can be further enhanced by serial studies. We report our experience with the use of this technique for study of 180 patients with clinically suspected DVT. Only 55 (30.6%) patients were confirmed to have DVT on duplex ultrasonography which illustrates the inaccuracy of bedside diagnosis of this potentially life-threatening condition. Almost all our DVT patients have proximal vein involvement, indicating that venous thrombosis usually do not cause signs or symptoms until they become large, occlusive and extend into the proximal veins. It is also observed in our study cohort that half of the patients with proximal vein thrombosis has incomplete recanalisation on follow-up study. None of them with normal study developed significant sequelae of untreated DVT, suggesting that it is safe to withhold treatment based on result of this non-invasive test. Duplex ultrasonography is the diagnostic modality of choice for suspected DVT in symptomatic patients and is an excellent substitute for conventional contrast venography.