1. Dexamethasone implant for refractory macular edema secondary to diabetic retinopathy and retinal vein occlusion
- Author
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Yuan-Yuan Zhong, Chong Tang, Lan-Yue Zhang, Xue-Dong Zhang, and Shu-Lin Liu
- Subjects
macular edema ,dexamethasone implant ,anti-vascular endothelial growth factor ,retinal vein occlusion ,diabetic retinopathy ,Ophthalmology ,RE1-994 - Abstract
AIM: To evaluate the efficacy, timing of retreatment and safety of dexamethasone (DEX) implant on macular edema (ME) secondary to diabetic retinopathy (DME) and retinal vein occlusion (RVO-ME) patients who were refractory to anti-vascular endothelial growth factor (VEGF) treatment. METHODS: This retrospective study included 37 eyes received at least one DEX implant treatment for DME or RVO-ME between January 1, 2019, and January 1, 2023. These refractory DME and RVO-ME cases received at least 5 anti-VEGF injections and failure to gain more than 5 letters or a significant reduction in central retinal thickness (CRT). The best corrected visual acuity (BCVA) and CRT were measured at baseline, and at 1, 3, 4 and 6mo post-DEX implant injection. Adverse events such as elevated intraocular pressure (IOP) and cataract were recorded. RESULTS: For RVO cases (n=22), there was a significant increase in BCVA from 0.27±0.19 to 0.35±0.20 at 6mo post-DEX injection (P
- Published
- 2024
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