Search

Your search keyword '"Chong, Yap Seng"' showing total 1,967 results
Start Over Author "Chong, Yap Seng"
1,967 results on '"Chong, Yap Seng"'

4. A global multicohort study to map subcortical brain development and cognition in infancy and early childhood.

Author

Alex, Ann, Aguate, Fernando, Botteron, Kelly, Buss, Claudia, Chong, Yap-Seng, Dager, Stephen, Donald, Kirsten, Entringer, Sonja, Fair, Damien, Fortier, Marielle, Gaab, Nadine, Gilmore, John, Girault, Jessica, Graham, Alice, Groenewold, Nynke, Hazlett, Heather, Lin, Weili, Meaney, Michael, Piven, Joseph, Qiu, Anqi, Rasmussen, Jerod, Roos, Annerine, Schultz, Robert, Skeide, Michael, Stein, Dan, Styner, Martin, Thompson, Paul, Turesky, Ted, Wadhwa, Pathik, Zar, Heather, Zöllei, Lilla, de Los Campos, Gustavo, and Knickmeyer, Rebecca

Subjects
Male, Female, Humans, Infant, Newborn, Child, Preschool, Child, Premature Birth, Cognition, Brain, Neuroimaging, Magnetic Resonance Imaging
Abstract

The human brain grows quickly during infancy and early childhood, but factors influencing brain maturation in this period remain poorly understood. To address this gap, we harmonized data from eight diverse cohorts, creating one of the largest pediatric neuroimaging datasets to date focused on birth to 6 years of age. We mapped the developmental trajectory of intracranial and subcortical volumes in ∼2,000 children and studied how sociodemographic factors and adverse birth outcomes influence brain structure and cognition. The amygdala was the first subcortical volume to mature, whereas the thalamus exhibited protracted development. Males had larger brain volumes than females, and children born preterm or with low birthweight showed catch-up growth with age. Socioeconomic factors exerted region- and time-specific effects. Regarding cognition, males scored lower than females; preterm birth affected all developmental areas tested, and socioeconomic factors affected visual reception and receptive language. Brain-cognition correlations revealed region-specific associations.

Published
2024

5. Exploring multi-omics and clinical characteristics linked to accelerated biological aging in Asian women of reproductive age: insights from the S-PRESTO study

Author

Chen, Li, Tan, Karen Mei-Ling, Xu, Jia, Mishra, Priti, Mir, Sartaj Ahmad, Gong, Min, Narasimhan, Kothandaraman, Ng, Bryan, Lai, Jun Shi, Tint, Mya Thway, Cai, Shirong, Sadananthan, Suresh Anand, Michael, Navin, Yaligar, Jadegoud, Velan, Sambasivam Sendhil, Leow, Melvin Khee Shing, Tan, Kok Hian, Chan, Jerry, Meaney, Michael J., Chan, Shiao-Yng, Chong, Yap Seng, and Eriksson, Johan G.

Published
2024
Full Text
View/download PDF

6. A Catalogue of Structural Variation across Ancestrally Diverse Asian Genomes

Author

Tan, Joanna Hui Juan, Li, Zhihui, Porta, Mar Gonzalez, Rajaby, Ramesh, Lim, Weng Khong, Tan, Ye An, Jimenez, Rodrigo Toro, Teo, Renyi, Hebrard, Maxime, Ow, Jack Ling, Ang, Shimin, Jeyakani, Justin, Chong, Yap Seng, Lim, Tock Han, Goh, Liuh Ling, Tham, Yih Chung, Leong, Khai Pang, Chin, Calvin Woon Loong, Davila, Sonia, Karnani, Neerja, Cheng, Ching-Yu, Chambers, John, Tai, E. Shyong, Liu, Jianjun, Sim, Xueling, Sung, Wing Kin, Prabhakar, Shyam, Tan, Patrick, and Bertin, Nicolas

Published
2024
Full Text
View/download PDF

8. Correlates of lifestyle patterns among children in Singapore aged 10 years: the Growing Up in Singapore Towards healthy Outcomes (GUSTO) study

Author

Tan, Sarah Yi Xuan, Chia, Airu, Tai, Bee Choo, Toh, Jia Ying, Colega, Marjorelee, Padmapriya, Natarajan, Setoh, Peipei, Kee, Michelle Zhi Ling, Yuan, Wen Lun, Lee, Yung Seng, Loo, Benny Kai Guo, Yap, Fabian Kok Peng, Tan, Kok Hian, Godfrey, Keith M., Chong, Yap Seng, Eriksson, Johan, Müller-Riemenschneider, Falk, and Chong, Mary Foong-Fong

Published
2024
Full Text
View/download PDF

9. The cross-sectional and prospective associations of parental practices and environmental factors with 24-hour movement behaviours among school-aged Asian children

Author

Padmapriya, Natarajan, Fogel, Anna, Tan, Sarah Yi Xuan, Goh, Claire Marie Jie Lin, Tan, Shuen Lin, Chia, Airu, Chu, Anne Hin Yee, Chong, Yap Seng, Tan, Kok Hian, Chan, Shiao-Yng, Yap, Fabian, Godfrey, Keith M., Lee, Yung Seng, Eriksson, Johan G., Tan, Chuen Seng, Bernard, Jonathan Y., and Müller-Riemenschneider, Falk

Published
2024
Full Text
View/download PDF

22. A machine-learning exploration of the exposome from preconception in early childhood atopic eczema, rhinitis and wheeze development

Author

Dong, Yizhi, Lau, Hui Xing, Suaini, Noor Hidayatul Aini, Kee, Michelle Zhi Ling, Ooi, Delicia Shu Qin, Shek, Lynette Pei-chi, Lee, Bee Wah, Godfrey, Keith M., Tham, Elizabeth Huiwen, Ong, Marcus Eng Hock, Liu, Nan, Wong, Limsoon, Tan, Kok Hian, Chan, Jerry Kok Yen, Yap, Fabian Kok Peng, Chong, Yap Seng, Eriksson, Johan Gunnar, Feng, Mengling, and Loo, Evelyn Xiu Ling

Published
2024
Full Text
View/download PDF

26. Plasma lipidomic profiling reveals metabolic adaptations to pregnancy and signatures of cardiometabolic risk: a preconception and longitudinal cohort study

Author

Chen, Li, Mir, Sartaj Ahmad, Bendt, Anne K., Chua, Esther W. L., Narasimhan, Kothandaraman, Tan, Karen Mei-Ling, Loy, See Ling, Tan, Kok Hian, Shek, Lynette P., Chan, Jerry, Yap, Fabian, Meaney, Michael J., Chan, Shiao-Yng, Chong, Yap Seng, Gluckman, Peter D., Eriksson, Johan G., Karnani, Neerja, and Wenk, Markus R.

Published
2023
Full Text
View/download PDF

27. Seemingly Unrelated Multi-State processes: a Bayesian semiparametric approach

Author

Cremaschi, Andrea, Argiento, Raffele, De Iorio, Maria, Shirong, Cai, Chong, Yap Seng, Meaney, Michael J., and Kee, Michelle Z. L.

Subjects
Statistics - Methodology
Abstract

Many applications in medical statistics as well as in other fields can be described by transitions between multiple states (e.g. from health to disease) experienced by individuals over time. In this context, multi-state models are a popular statistical technique, in particular when the exact transition times are not observed. The key quantities of interest are the transition rates, capturing the instantaneous risk of moving from one state to another. The main contribution of this work is to propose a joint semiparametric model for several possibly related multi-state processes (Seemingly Unrelated Multi-State, SUMS, processes), assuming a Markov structure for the transitions over time. The dependence between different processes is captured by specifying a joint random effect distribution on the transition rates of each process. We assume a flexible random effect distribution, which allows for clustering of the individuals, overdispersion and outliers. Moreover, we employ a graph structure to describe the dependence among processes, exploiting tools from the Gaussian Graphical model literature. It is also possible to include covariate effects. We use our approach to model disease progression in mental health. Posterior inference is performed through a specially devised MCMC algorithm.

Published
2021

28. The Effect of Older Sibling, Postnatal Maternal Stress, and Household Factors on Language Development in Two- to Four-Year-Old Children

Author

Havron, Naomi, Lovcevic, Irena, Kee, Michelle Z. L., Chen, Helen, Chong, Yap Seng, Daniel, Mary, Broekman, Birit F. P., and Tsuji, Sho

Abstract

Previous literature has shown that family structure affects language development. Here, factors relating to older siblings (their presence in the house, sex, and age gap), mothers (maternal stress), and household size and residential crowding were assessed to systematically examine the different roles of these factors. Data from mother-child dyads in a Singaporean birth cohort, (677-855 dyads; 52% males; 58% to 61% Chinese, 20% to 24% Malay, 17% to 19% Indian) collected when children were 24, 48, and 54 months old, were analyzed. There was a negative effect of having an older sibling, moderated by the siblings' age gap, but not by the older sibling's sex, nor household size or residential crowding. Maternal stress affected language outcomes in some analyses but not others. Implications for understanding the possible effects of family structure on language development are discussed.

Published
2022
Full Text
View/download PDF

30. Effect of an Asian-adapted Mediterranean diet and pentadecanoic acid on fatty liver disease: the TANGO randomized controlled trial

Author

Lim, Kezlyn Li Ming, Kouk, Mabel Shu Fung, Mei Chong, Evelyn Wai, Gani, Munirah Abd, Li, Lisha, Tay, Vicky Hwee Kee, Kway, Yeshe Manuel, Kumar, Mukkesh, Sadananthan, Suresh Anand, Khoo, Kaijie, Koh, Danyu, Lim, Rebecca, Kang, Chin Wei, Sin, Kwang Li, Lim, Jun Wei, Chooi, Yu Chung, Zhang, Qinze Arthur, Magkos, Faidon, Ng, Maisie, Michael, Navin, Wu, Xiaorong, Volchanskaya, Vera Sergeyevna Brok, Lai, Xianning, Wanjaya, Elvy Riani, Elejalde, Untzizu, Goh, Chew Chan, Yap, Clara Poh Lian, Wong, Long Hui, Lim, Kevin Junliang, Velan, S. Sendhil, Yaligar, Jadegoud, Muthiah, Mark Dhinesh, Chong, Yap Seng, Loo, Evelyn Xiu Ling, and Eriksson, Johan G.

Published
2024
Full Text
View/download PDF

32. The prospective associations of fetal growth-related pregnancy complications with subsequent breastfeeding duration and markers of human milk production

Author

Pang, Wei Wei, Geddes, Donna T, Lai, Ching-Tat, Michael, Navin, Huang, Jonathan, Chan, Yiong Huak, Cheong, Clara Y, Fok, Doris, Pundir, Shikha, Ng, Sharon, Vickers, Mark H, Chua, Mei Chien, Tan, Kok Hian, Godfrey, Keith M, Shek, Lynette P, Chong, Yap-Seng, Eriksson, Johan G, Chan, Shiao-Yng, and Wlodek, Mary E

Published
2024
Full Text
View/download PDF

34. Associations of cord plasma per- and polyfluoroakyl substances (PFAS) with neonatal and child body composition and adiposity: The GUSTO study

Author

Chen, Ling-Wei, Ng, Sharon, Tint, Mya-Thway, Michael, Navin, Sadananthan, Suresh Anand, Ong, Yi Ying, Yuan, Wen Lun, Chen, Ze-Ying, Chen, Chia-Yang, Godfrey, Keith M., Tan, Kok Hian, Gluckman, Peter D., Chong, Yap-Seng, Eriksson, Johan G., Yap, Fabian, Lee, Yung Seng, Fortier, Marielle V., Velan, Sendhil S., and Chan, Shiao-Yng

Published
2024
Full Text
View/download PDF

38. A nutritional supplement during preconception and pregnancy increases human milk vitamin D but not B-vitamin concentrations

Author

Albert, Benjamin B., Barton, Shelia J., Binia, Aristea, Cavanagh, Mary, Chang, Hsin Fang, Chong, Yap Seng, Chong, Mary F., Conlon, Cathryn, Cooper, Cyrus, Costello, Paula, Cox, Vanessa, Creagh, Christine, Depczynski, Marysia, El-Heis, Sarah, Hammond, Judith, Harvey, Nicholas C., Jagtap, Mrunalini, Kenealy, Timothy, Nield, Heidi, O'Sullivan, Justin M., Satianegara, Gernalia, Silva-Zolezz, Irma, Soh, Shu E., Tay, Vicky, Taylor, Rachael, Tham, Elizabeth, Titcombe, Philip, Wall, Clare, Wong, Ray, Woon, Gladys, Han, Zhang, Han, Soo Min, Huang, Fang, Derraik, José G.B., Vickers, Mark H., Devaraj, Surabhi, Redeuil, Karine, Campos-Giménez, Esther, Pang, Wei Wei, Godfrey, Keith M., Chan, Shiao-Yng, Thakkar, Sagar K., and Cutfield, Wayne S.

Published
2023
Full Text
View/download PDF

39. Cross-sectional and prospective associations between children's 24-h time use and their health-related quality of life: a compositional isotemporal substitution approach

Author

Tan, Sarah Yi Xuan, Padmapriya, Natarajan, Bernard, Jonathan Y., Toh, Jia Ying, Wee, Hwee-Lin, Tan, Kok Hian, Yap, Fabian Kok Peng, Lee, Yung Seng, Chong, Yap-Seng, Godfrey, Keith, Eriksson, Johan Gunnar, Shek, Lynette Pei-Chi, Tan, Chuen Seng, Chong, Mary Foong-Fong, and Müller-Riemenschneider, Falk

Published
2023
Full Text
View/download PDF

40. A fully convolutional neural network for comprehensive compartmentalization of abdominal adipose tissue compartments in MRI

Author

Kway, Yeshe M., Thirumurugan, Kashthuri, Michael, Navin, Tan, Kok Hian, Godfrey, Keith M., Gluckman, Peter, Chong, Yap Seng, Venkataraman, Kavita, Khoo, Eric Yin Hao, Khoo, Chin Meng, Leow, Melvin Khee-Shing, Tai, E Shyong, Chan, Jerry KY., Chan, Shiao-Yng, Eriksson, Johan G., Fortier, Marielle V., Lee, Yung Seng, Velan, S. Sendhil, Feng, Mengling, and Sadananthan, Suresh Anand

Published
2023
Full Text
View/download PDF

41. Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial

Author

Godfrey, Keith M., Titcombe, Philip, El-Heis, Sarah, Albert, Benjamin B., Tham, Elizabeth Huiwen, Barton, Sheila J., Kenealy, Timothy, Chong, Mary Foong-Fong, Nield, Heidi, Chong, Yap Seng, Chan, Shiao-Yng, and Cutfield, Wayne S.

Subjects
Glucose tolerance tests -- Analysis, Alfacalcidol -- Analysis, Dietary supplements -- Analysis, Clinical trials -- Analysis, Pregnant women -- Analysis, Phosphates -- Analysis, Pregnancy -- Analysis, Folic acid -- Analysis, Inositol -- Analysis, Calcifediol -- Analysis, Vitamin D -- Analysis, Ethylenediaminetetraacetic acid -- Analysis, Beta carotene -- Analysis, Biological sciences
Abstract

Background Maternal vitamin status preconception and during pregnancy has important consequences for pregnancy outcome and offspring development. Changes in vitamin status from preconception through early and late pregnancy and postpartum have been inferred from cross-sectional data, but longitudinal data on vitamin status from preconception throughout pregnancy and postdelivery are sparse. As such, the influence of vitamin supplementation on vitamin status during pregnancy remains uncertain. This study presents one prespecified outcome from the randomized controlled NiPPeR trial, aiming to identify longitudinal patterns of maternal vitamin status from preconception, through early and late pregnancy, to 6 months postdelivery, and determine the influence of vitamin supplementation. Methods and findings In the NiPPeR trial, 1,729 women (from the United Kingdom, Singapore, and New Zealand) aged 18 to 38 years and planning conception were randomized to receive a standard vitamin supplement (control; n = 859) or an enhanced vitamin supplement (intervention; n = 870) starting in preconception and continued throughout pregnancy, with blinding of participants and research staff. Supplement components common to both treatment groups included folic acid, [beta]-carotene, iron, calcium, and iodine; components additionally included in the intervention group were riboflavin, vitamins B6, B12, and D (in amounts available in over-the-counter supplements), myo-inositol, probiotics, and zinc. The primary outcome of the study was glucose tolerance at 28 weeks' gestation, measured by oral glucose tolerance test. The secondary outcome reported in this study was the reduction in maternal micronutrient insufficiency in riboflavin, vitamin B6, vitamin B12, and vitamin D, before and during pregnancy. We measured maternal plasma concentrations of B-vitamins, vitamin D, and markers of insufficiency/deficiency (homocysteine, hydroxykynurenine-ratio, methylmalonic acid) at recruitment, 1 month after commencing intervention preconception, in early pregnancy (7 to 11 weeks' gestation) and late pregnancy (around 28 weeks' gestation), and postdelivery (6 months after supplement discontinuation). We derived standard deviation scores (SDS) to characterize longitudinal changes among participants in the control group and measured differences between the 2 groups. At recruitment, the proportion of patients with marginal or low plasma status was 29.2% for folate ( Conclusions Over 90% of the trial participants had marginal or low concentrations of one or more of folate, riboflavin, vitamin B12, or vitamin D during preconception, and many developed markers of vitamin B6 deficiency in late pregnancy. Preconception/pregnancy supplementation in amounts available in over-the-counter supplements substantially reduces the prevalence of vitamin deficiency and depletion markers before and during pregnancy, with higher maternal plasma vitamin B12 maintained during the recommended lactational period. Trial registration ClinicalTrials.gov NCT02509988; U1111-1171-8056., Author(s): Keith M. Godfrey 1,2,*, Philip Titcombe 1, Sarah El-Heis 1,2, Benjamin B. Albert 3, Elizabeth Huiwen Tham 4, Sheila J. Barton 1, Timothy Kenealy 3, Mary Foong-Fong Chong 4,5, [...]

Published
2023
Full Text
View/download PDF

46. Preconception sleep quality moderates the association between preconception hair cortisol levels and mental health in pregnant women

Author

Abdul Jafar, Nur K., Tham, Elaine K.H., Eng, Derric Z.H., Yeo, Sherwynn, Rifkin-Graboi, Anne, Gooley, Joshua J., Loy, See Ling, Eriksson, Johan G., Chong, Yap-Seng, Tan, Kok Hian, Chan, Jerry Kok Yen, Chen, Helen, Shek, Lynette Pei-Chi, Gluckman, Peter D., Yap, Fabian, Meaney, Michael J., Broekman, Birit F.P., Kee, Michelle Z.L., and Cai, Shirong

Published
2023
Full Text
View/download PDF

47. Time-to-conception and clinical pregnancy rate with a myo-inositol, probiotics, and micronutrient supplement: secondary outcomes of the NiPPeR randomized trial

Author

Albert, Ben, Cai, Shirong, Calder, Philip C., Carvalho, Ryan, Guiao Castro, Julie Ann, Cavanagh, Mary, Chan, Jerry KY., Chang, Mei Ling, Chi, Claudia, Childs, Caroline E., Choh, Mei Kit, Chong, Mary FF., Chu, Anne HY., Conlon, Cathryn, Paula Costello, Cyrus Cooper, Cox, Vanessa, Galani, Sevasti, Hammond, Judith, Harvey, Nicholas C., Holt, Richard, Inskip, Hazel M., Jagtap, Mrunalini, Jeon, Gene, Karnani, Neerja, Nembrini, Chiara, Lillycrop, Karen A., Müller-Riemenschneider, Falk, Natarajan, Padmapriya, Ng, Sharon, Ramasamy, Adaikalavan, Tham, Elizabeth, Tint, Mya Thway, O’Sullivan, Justin M., Satianegara, Gernalia, Shek, Lynette PC., Silva-Zolezzi, Irma, Sim, Wendy, Soh, Shu E., Tay, Vicky, Taylor, Rachel, Theodosia, Salika, Wall, Clare, Woon, Gladys, Vickers, Mark, Ying, Wei, Chan, Shiao-Yng, Barton, Sheila J., Loy, See Ling, Chang, Hsin Fang, Titcombe, Philip, Wong, Jui-Tsung, Ebreo, Marilou, Ong, Judith, Tan, Karen ML., Nield, Heidi, El-Heis, Sarah, Kenealy, Timothy, Chong, Yap-Seng, Baker, Philip N., Cutfield, Wayne S., and Godfrey, Keith M.

Published
2023
Full Text
View/download PDF

49. A five-safes approach to a secure and scalable genomics data repository

Author

Shih, Chih Chuan, Chen, Jieqi, Lee, Ai Shan, Bertin, Nicolas, Hebrard, Maxime, Khor, Chiea Chuen, Li, Zheng, Juan Tan, Joanna Hui, Meah, Wee Yang, Peh, Su Qin, Mok, Shi Qi, Sim, Kar Seng, Liu, Jianjun, Wang, Ling, Wong, Eleanor, Li, Jingmei, Tin, Aung, Cheng, Ching-Yu, Heng, Chew-Kiat, Yuan, Jian-Min, Koh, Woon-Puay, Saw, Seang Mei, Friedlander, Yechiel, Sim, Xueling, Chai, Jin Fang, Chong, Yap Seng, Davila, Sonia, Goh, Liuh Ling, Lee, Eng Sing, Wong, Tien Yin, Karnani, Neerja, Leong, Khai Pang, Yeo, Khung Keong, Chambers, John C., Lim, Su Chi, Goh, Rick Siow Mong, Tan, Patrick, and Dorajoo, Rajkumar

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results