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This article presents a retrospective study conducted at the National Skin Centre in Singapore from 2012 to 2021. The study aimed to identify trends in contact allergies to preservatives. A total of 4,585 patients were included in the study, with the majority being female. The most common preservatives that patients were sensitized to were MI, MCI/MI, paraben mix, and Quaternium 15. Sensitization frequencies for MDBGN and formaldehyde were lower, while sensitization to other preservatives was less than 1%. None of the patients had a positive reaction to 2-Phenoxyethanol. The study also found that the most common site affected by dermatitis was the hands, followed by the face and/or neck. Toiletries were the main source of allergens, and delayed positive patch tests were observed in a small percentage of cases. The study compared sensitization frequencies of preservatives between different time periods and found that the sensitization frequency of MCI/MI had increased, while the prevalence of paraben sensitivity had decreased, possibly due to regulations. The article emphasizes the importance of conducting a second patch test reading and notes that personal care products were common sources of allergens. [Extracted from the article]