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4. Development of new adeno-associated virus capsid variants for targeted gene delivery to human cardiomyocytes

Author

Kok, Cindy Y., Tsurusaki, Shinya, Cabanes-Creus, Marti, Igoor, Sindhu, Rao, Renuka, Skelton, Rhys, Liao, Sophia H.Y., Ginn, Samantha L., Knight, Maddison, Scott, Suzanne, Mietzsch, Mario, Fitzsimmons, Rebecca, Miller, Jessica, Mohamed, Tamer M.A., McKenna, Robert, Chong, James J.H., Hill, Adam P., Hudson, James E., Alexander, Ian E., Lisowski, Leszek, and Kizana, Eddy

Published
2023
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7. Vascular cells improve functionality of human cardiac organoids

Author

Voges, Holly K., Foster, Simon R., Reynolds, Liam, Parker, Benjamin L., Devilée, Lynn, Quaife-Ryan, Gregory A., Fortuna, Patrick R.J., Mathieson, Ellen, Fitzsimmons, Rebecca, Lor, Mary, Batho, Christopher, Reid, Janice, Pocock, Mark, Friedman, Clayton E., Mizikovsky, Dalia, Francois, Mathias, Palpant, Nathan J., Needham, Elise J., Peralta, Marina, Monte-Nieto, Gonzalo del, Jones, Lynelle K., Smyth, Ian M., Mehdiabadi, Neda R., Bolk, Francesca, Janbandhu, Vaibhao, Yao, Ernestene, Harvey, Richard P., Chong, James J.H., Elliott, David A., Stanley, Edouard G., Wiszniak, Sophie, Schwarz, Quenten, James, David E., Mills, Richard J., Porrello, Enzo R., and Hudson, James E.

Published
2023
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17. Clinical Pathway for Coronary Atherosclerosis in Patients Without Conventional Modifiable Risk Factors

Author

Figtree, Gemma A., primary, Vernon, Stephen T., additional, Harmer, Jason A., additional, Gray, Michael P., additional, Arnott, Clare, additional, Bachour, Eric, additional, Barsha, Giannie, additional, Brieger, David, additional, Brown, Alex, additional, Celermajer, David S., additional, Channon, Keith M., additional, Chew, Nicholas W.S., additional, Chong, James J.H., additional, Chow, Clara K., additional, Cistulli, Peter A., additional, Ellinor, Patrick T., additional, Grieve, Stuart M., additional, Guzik, Tomasz J., additional, Hagström, Emil, additional, Jenkins, Alicia, additional, Jennings, Garry, additional, Keech, Anthony C., additional, Kott, Katharine A., additional, Kritharides, Leonard, additional, Mamas, Mamas A., additional, Mehran, Roxana, additional, Meikle, Peter J., additional, Natarajan, Pradeep, additional, Negishi, Kazuaki, additional, O’Sullivan, John, additional, Patel, Sanjay, additional, Psaltis, Peter J., additional, Redfern, Julie, additional, Steg, Philippe G., additional, Sullivan, David R., additional, Sundström, Johan, additional, Vogel, Birgit, additional, Wilson, Andrew, additional, Wong, Dennis, additional, Bhatt, Deepak L., additional, Kovacic, Jason C., additional, Nicholls, Stephen J., additional, Ademi, Zanfina, additional, Avis, Suzanne Robyn, additional, Chan, Adam, additional, Contreras, Osvaldo, additional, Coorey, Craig P., additional, Fathieh, Sina, additional, Genetzakis, Elijah, additional, Gholipour, Alireza, additional, Giles, Corey, additional, Hollings, Matthew, additional, Hyun, Karice, additional, Kazi, Samia, additional, Larance, Mark, additional, Marathe, Jessica A., additional, Marquina, Clara, additional, Nelson, Adam, additional, Ng, Hooi Hooi, additional, Patrick, Ellis, additional, Peter, Karlheinz, additional, Tran, Andy, additional, Yang, Jean, additional, Zhu, Dantong, additional, and Zwack, Clara, additional

Published
2023
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22. Tropoelastin Improves Post-Infarct Cardiac Function

Author

Hume, Robert D., primary, Kanagalingam, Shaan, additional, Deshmukh, Tejas, additional, Chen, Siqi, additional, Mithieux, Suzanne M., additional, Rashid, Fairooj N., additional, Roohani, Iman, additional, Lu, Juntang, additional, Doan, Tram, additional, Graham, Dinny, additional, Clayton, Zoe E., additional, Slaughter, Eugene, additional, Kizana, Eddy, additional, Stempien-Otero, April S., additional, Brown, Paula, additional, Thomas, Liza, additional, Weiss, Anthony S., additional, and Chong, James J.H., additional

Published
2023
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25. Cellular Heterogeneity of Pluripotent Stem Cell Derived Cardiomyocyte Grafts is Mechanistically Linked to Treatable Arrhythmias

Author

Selvakumar, Dinesh, primary, Clayton, Zoe E., additional, Prowse, Andrew, additional, Dingwall, Steve, additional, George, Jacob, additional, Shah, Haisam, additional, Chen, Siqi, additional, Hume, Robert D., additional, Tjahjadi, Laurentius, additional, Igoor, Sindhu, additional, Skelton, Rhys J.P., additional, Hing, Alfred, additional, Paterson, Hugh, additional, Foster, Sheryl L., additional, Pearson, Lachlan, additional, Wilkie, Emma, additional, Jeyaprakash, Prajith, additional, Wu, Zhixuan, additional, McArthur, Jeffrey R., additional, Barry, Tony, additional, Lu, Juntang, additional, Tran, Vu, additional, Bennett, Richard, additional, Kotake, Yasuhito, additional, Campbell, Timothy, additional, Turnbull, Samual, additional, Nguyen, Quan, additional, Ni, Guiyan, additional, Grieve, Stuart M., additional, Palpant, Nathan J., additional, Pathan, Faraz, additional, Kizana, Eddy, additional, Kumar, Saurabh, additional, Gray, Peter P., additional, and Chong, James J.H., additional

Published
2022
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28. Adult Cardiac-Resident MSC-like Stem Cells with a Proepicardial Origin

Author

Chong, James J.H., Chandrakanthan, Vashe, Xaymardan, Munira, Asli, Naisana S., Li, Joan, Ahmed, Ishtiaq, Heffernan, Corey, Menon, Mary K., Scarlett, Christopher J., Rashidianfar, Amirsalar, Biben, Christine, Zoellner, Hans, Colvin, Emily K., Pimanda, John E., Biankin, Andrew V., Zhou, Bin, Pu, William T., Prall, Owen W.J., and Harvey, Richard P.

Published
2011
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29. Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts

Author

Chong, James J.H., Yang, Xiulan, Don, Creighton W., Minami, Elina, Liu, Yen-Wen, Weyers, Jill J., Mahoney, Jr., William M., Van Biber, Benjamin, Cook, Savannah M., Palpant, Nathan J., Gantz, Jay A., Fugate, James A., Muskheli, Veronica, Gough, G. Michael, Vogel, Keith W., Astley, Cliff A., Hotchkiss, Charlotte E., Baldessari, Audrey, Pabon, Lil, Reinecke, Hans, Gill, Edward A., Nelson, Veronica, Kiem, Hans-Peter, Laflamme, Michael A., and Murry, Charles E.

Subjects
Research, Regeneration (Biology) -- Research, Embryonic stem cells -- Research, Heart cells -- Research, Stem cell research
Abstract

Human pluripotent stem cells have indisputable cardiomyocyte-generating abilities and have been extensively investigated for repair of the injured heart (3,4,6,10). These stem cells are derived either from developing blastocytsts (human [...], Pluripotent stem cells provide a potential solution to current epidemic rates of heart failure (1) by providing human cardiomyocytes to support heart regeneration (2). Studies of human embryonic-stem-cell-derived cardiomyocytes (hESC-CMs) in small-animal models have shown favourable effects of this treatment (3-7). However, it remains unknown whether clinical-scale hESC-CM transplantation is feasible, safe or can provide sufficient myocardial regeneration. Here we show that hESC-CMs can be produced at a clinical scale (more than one billion cells per batch) and cryopreserved with good viability. Using a non-human primate model of myocardial ischaemia followed by reperfusion, we show that cryopreservation and intramyocardial delivery of one billion hESC-CMs generates extensive remuscularization of the infarcted heart. The hESC-CMs showed progressive but incomplete maturation over a 3-month period. Grafts were perfused by host vasculature, and electromechanical junctions between graft and host myocytes were present within 2 weeks of engraftment. Importantly, grafts showed regular calcium transients that were synchronized to the host electrocardiogram, indicating electromechanical coupling. In contrast to small-animal models (7),nonfatal ventricular arrhythmias were observed in hESC-CM-engrafted primates. Thus, hESC-CMs can remuscularize substantial amounts of the infarcted monkey heart. Comparable remuscularization of a human heart should be possible, but potential arrhythmic complications need to be overcome.

Published
2014

36. Association between plasma neutrophil gelatinase-associated lipocalin and cardiac disease hospitalizations and deaths in older women

Author

Chong, James J.H., Prince, Richard L., Thompson, Peter L., Thavapalachandran, Sujitha, Ooi, Esther, Devine, Amanda, Lim, E E.M., Byrnes, Elizabeth, Wong, Germaine, Lim, Wai H., Lewis, Joshua R., Chong, James J.H., Prince, Richard L., Thompson, Peter L., Thavapalachandran, Sujitha, Ooi, Esther, Devine, Amanda, Lim, E E.M., Byrnes, Elizabeth, Wong, Germaine, Lim, Wai H., and Lewis, Joshua R.

Abstract

Background Neutrophil gelatinase-associated lipocalin ( NGAL ) or lipocalin 2 may promote atherosclerosis and plaque instability leading to increased risk of cardiac events. We investigated the relationships between plasma NGAL , cardiovascular disease biomarkers, and long-term cardiac events. Methods and Results The study population consisted of 1131 ambulant older white women (mean age 75 years) without clinical coronary heart disease ( CHD ) and measures of plasma NGAL in the Perth Longitudinal Study of Ageing Women with 14.5-year CHD and heart failure hospitalizations or death (events) captured using linked records. Over 14.5 years, 256 women had CHD events, while 118 had heart failure events. Per SD increase in log-transformed NGAL there was a 35% to 37% increase in relative hazards for CHD and heart failure events in unadjusted analyses, which remained significant after adjustment for conventional risk factors for CHD events (hazard ratio 1.29, 95% CI 1.13-1.48, P0.05). Women in the highest 2 quartiles of NGAL had higher relative hazards for CHD events compared with women in the lowest quartile hazard ratio 1.61, 95% CI 1.08-2.39, P=0.019 and hazard ratio 1.97, 95% CI 1.33-3.93, P=0.001, respectively. These associations were independent of high-sensitivity cardiac troponin I, homocysteine, and estimated renal function. NGAL correctly reclassified 1 in 4 women who sustained a CHD event up in risk and 1 in 10 women without CHD events down in risk. Conclusions NGAL was associated with increased risk of long-term CHD events, independent of conventional risk factors and biomarkers. These findings provide mechanistic insight into the role of NGAL with cardiac events.

Published
2019

38. PDGFRα signaling in cardiac fibroblasts modulates quiescence, metabolism and self-renewal, and promotes anatomical and functional repair

Author

Asli, Naisana S., primary, Xaymardan, Munira, additional, Patrick, Ralph, additional, Farbehi, Nona, additional, Cornwell, James, additional, Forte, Elvira, additional, Waardenberg, Ashley J., additional, Janbandhu, Vaibhao, additional, Kesteven, Scott, additional, Chandrakanthan, Vashe, additional, Malinowska, Helena, additional, Reinhard, Henrik, additional, Schofield, Peter, additional, Christ, Daniel, additional, Ahmed, Ishtiaq, additional, Bouveret, Romaric, additional, Srivastava, Surabhi, additional, Mishra, Rakesh K., additional, Dhawan, Jyotsna, additional, Chong, James J.H., additional, Nordon, Robert, additional, Macdonald, Peter, additional, Graham, Robert M., additional, Feneley, Michael, additional, and Harvey, Richard P., additional

Published
2017
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42. Vascular cells improve function and disease modelling in human cardiac organoids

Author

Voges, Holly K., Foster, Simon R., Reynolds, Liam, Parker, Benjamin L., Devilée, Lynn, Quaife-Ryan, Gregory A., Fortuna, Patrick R.J., Mathieson, Ellen, Fitzsimmons, Rebecca, Lor, Mary, Batho, Christopher, Reid, Janice, Pocock, Mark, Friedman, Clayton E., Mizikovsky, Dalia, Francois, Mathias, Palpant, Nathan J., Needham, Elise J., Peralta, Marina, Monte-Nieto, Gonzalo del, Jones, Lynelle K, Smyth, Ian M., Mehdiabadi, Neda R., Bolk, Francesca, Janbandhu, Vaibhao, Yao, Ernestene, Harvey, Richard P., Chong, James J.H., Elliott, David A., Stanley, Edouard G., Wiszniak, Sophie, Schwarz, Quenten, James, David E., Mills, Richard J., Porrello, Enzo R., and Hudson, James E.

Abstract

Crosstalk between cardiac cells is critical for heart performance. Here we show that vascular cells within human cardiac organoids (hCO) enhance their maturation, force of contraction and utility in disease modelling. Herein we optimize our protocol to generate vascular populations in addition to epicardial, fibroblast and cardiomyocyte cells which self-organize into in vivo like structures in hCOs. We identify mechanisms of communication between endothelial cells, pericytes, fibroblasts and cardiomyocytes that ultimately contribute to cardiac organoid maturation. In particular that 1) endothelial-derived LAMA5 regulates expression of mature sarcomeric proteins and contractility, and 2) paracrine PDGFRβ signaling from vascular cells, upregulates matrix deposition to augment hCO contractile force. Finally, we demonstrate that vascular cells determine the magnitude of diastolic dysfunction caused by inflammatory factors and identify a paracrine role of endothelin driving dysfunction. Together this study highlights the importance and role of vascular cells in organoid models.

Published
2023
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43. Erythrocyte interaction with neutrophil extracellular traps in coronary artery thrombosis following myocardial infarction

Author

Chilingaryan, Zorik, Deshmukh, Tejas, Leung, Halina H.L., Perdomo, Jose, Emerson, Peter, Kurup, Rahul, Chong, Beng H., and Chong, James J.H.

Abstract

Cardiovascular disease, including myocardial infarction (MI), is the leading cause of death globally. Current antithrombotic medications used during MI treatment are predominantly directed towards platelet inhibition and, to a lesser extent, anticoagulation. Bleeding is a major risk of such treatment and could be circumvented by targeting other causative factors essential for arterial thrombus formation.

Published
2021
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44. Association between plasma neutrophil gelatinase-associated lipocalin and cardiac disease hospitalizations and deaths in older women

Author

Chong, James J.H., Prince, Richard L., Thompson, Peter L., Thavapalachandran, Sujitha, Ooi, Esther, Devine, Amanda, Lim, E E.M., Byrnes, Elizabeth, Wong, Germaine, Lim, Wai H., Lewis, Joshua R., Chong, James J.H., Prince, Richard L., Thompson, Peter L., Thavapalachandran, Sujitha, Ooi, Esther, Devine, Amanda, Lim, E E.M., Byrnes, Elizabeth, Wong, Germaine, Lim, Wai H., and Lewis, Joshua R.

Abstract

Chong, J. J., Prince, R. L., Thompson, P. L., Thavapalachandran, S., Ooi, E., Devine, A., ... & Lewis, J. R. (2019). Association between plasma neutrophil gelatinase-associated lipocalin and cardiac disease hospitalizations and deaths in older women. Journal of the American Heart Association, 8(1), e011028. Available here.

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